ISSN:
0749-1581
Keywords:
Morphine
;
3-O-Acetylmorphine
;
6-O-Acetylmorphine
;
Diacetylmorphine
;
Heroin
;
500 MHz
;
1H NMR spectra
;
COSY spectrum
;
Complete coupling and chemical shift data
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
High-resolution 1H NMR (500 MHz) spectra were recorded for morphine, 3-O-acetylmorphine, 6-O-acetylmorphine and diacetylmorphine (heroin). Complete assignment of all proton resonances was made for these substances following determination of accurate chemical shift and coupling data by spectral simulation of all tightly coupled proton resonance patterns. Chemical shifts and proton couplings are discussed in terms of the conformation of rings C and D. From a varied collection of morphine analogs, torsion angles for ring D protons were obtained from crystallographic studies. The corresponding coupling constants were calculated, they demonstrate similar conformation of the ring D for the compared morphine compounds.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260250108
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