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  • 1
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    Breast cancer risks for BRCA1/2 carriers (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wacholder, Sholom -- Struewing, Jeffery P -- Hartge, Patricia -- Greene, Mark H -- Tucker, Margaret A -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2187-91; author reply 2187-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15622558" target="_blank"〉PubMed〈/a〉
    Keywords: Breast Neoplasms/epidemiology/*genetics ; Female ; *Genes, BRCA1 ; *Genes, BRCA2 ; *Genetic Predisposition to Disease ; Heterozygote ; Humans ; Jews/genetics ; *Mutation ; Ovarian Neoplasms/epidemiology/genetics ; Risk ; Selection Bias
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Breast cancer risks for BRCA1/2 carriers (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Easton, Douglas F -- Hopper, John L -- Thomas, Duncan C -- Antoniou, Antonis -- Pharoah, Paul D P -- Whittemore, Alice S -- Haile, Robert W -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2187-91; author reply 2187-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15622557" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Breast Neoplasms/epidemiology/*genetics ; Female ; *Genes, BRCA1 ; *Genes, BRCA2 ; *Genetic Predisposition to Disease ; Heterozygote ; Humans ; Jews/genetics ; Middle Aged ; Mutation ; Penetrance ; Risk ; Selection Bias
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Research ethics and the EPA (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Childress, James F -- Taylor, Michael R -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2191; author reply 2191.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15622559" target="_blank"〉PubMed〈/a〉
    Keywords: Bioethical Issues ; Ethics Committees, Research ; *Ethics, Research ; *Government Regulation ; Human Experimentation/*ethics/standards ; Humans ; *Research Subjects ; United States ; *United States Environmental Protection Agency
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Microbiology. Peptide signals sense and destroy target cells (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garsin, Danielle A -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2202-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, TX 77030, USA. danielle.a.garsin@uth.tmc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15619588" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Proteins/biosynthesis/chemistry/genetics/*metabolism ; Bacteriocins ; Enterococcus faecalis/genetics/*metabolism/*pathogenicity ; Erythrocyte Membrane/metabolism ; Erythrocytes/*physiology ; Gene Expression Regulation, Bacterial ; *Hemolysis ; Humans ; Models, Biological ; Operon ; Protein Subunits/metabolism ; Virulence ; Virulence Factors/biosynthesis/chemistry/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Public health. Will vaccines be available for the next influenza pandemic? (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stohr, Klaus -- Esveld, Marja -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2195-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉World Health Organization Influenza Programme, Geneva, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15618505" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials as Topic ; *Disease Outbreaks ; Drug Industry ; Humans ; Influenza A virus/immunology/pathogenicity ; Influenza Vaccines/administration & dosage/economics/*supply & distribution ; Influenza, Human/*epidemiology/*prevention & control/virology ; International Cooperation ; Population Surveillance ; Public Policy ; World Health Organization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Presidential address. What is good for children is good for mankind: the role of imagination in discovery (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Avery, Mary Ellen -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2212-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15618508" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Child Welfare ; Forecasting ; Global Health ; Humans ; *Imagination ; Knowledge ; Population Growth ; Public Health ; *Research ; *Science ; United Nations
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Enterococcus faecalis senses target cells and in response expresses cytolysin (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-25
    Description: Many virulent strains of Enterococcus faecalis produce a two-subunit toxin, termed cytolysin. Cytolysin expression is regulated by one of the subunits (CylL(S)'') through a quorum-sensing autoinduction mechanism. We found that when target cells are absent, the other subunit (CylL(L)'') forms a complex with CylL(S)'', blocking it from autoinducing the operon. When target cells are present, however, CylL(L)'' binds preferentially to the target, allowing free CylL(S)'' to accumulate above the induction threshold. Thus, enterococci use CylL(L)'' to actively probe the environment for target cells, and when target cells are detected, allows the organism to express high levels of cytolysin in response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coburn, Phillip S -- Pillar, Christopher M -- Jett, Bradley D -- Haas, Wolfgang -- Gilmore, Michael S -- AI041108/AI/NIAID NIH HHS/ -- EY08289/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2270-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Stanton L. Young Biomedical Research Center, Room 356, Post Office Box 26901, Oklahoma City, OK 73190, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15618522" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Proteins/biosynthesis/chemistry/genetics/*metabolism ; Bacteriocins ; Enterococcus faecalis/genetics/*metabolism/*pathogenicity ; Erythrocyte Membrane/metabolism ; Erythrocytes/*physiology ; Gene Expression Regulation, Bacterial ; Genes, Bacterial ; Hemolysis ; Humans ; Lipid Bilayers/metabolism ; Models, Biological ; Operon ; Protein Subunits/metabolism ; Surface Plasmon Resonance ; Virulence ; Virulence Factors/biosynthesis/chemistry/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Molecular biology. Long-sought enzyme found, revealing new gene switch on histones (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2171.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15618494" target="_blank"〉PubMed〈/a〉
    Keywords: *Gene Expression Regulation ; Histone Demethylases ; Histones/*metabolism ; Humans ; Methylation ; Oxidoreductases, N-Demethylating/*metabolism ; RNA Interference
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Clinical trials. Halt of Celebrex study threatens drug's future, other trials (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2170.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15618492" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/prevention & control ; Celecoxib ; *Clinical Trials as Topic ; Colonic Polyps/drug therapy/prevention & control ; Cyclooxygenase Inhibitors/*adverse effects/*therapeutic use ; Drug Industry ; Humans ; Myocardial Infarction/chemically induced ; National Institutes of Health (U.S.) ; Pyrazoles/*adverse effects/*therapeutic use ; Stroke/chemically induced ; Sulfonamides/*adverse effects/*therapeutic use ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    High-energy physics. Report slams SLAC's safety practices (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cho, Adrian -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2169.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15618491" target="_blank"〉PubMed〈/a〉
    Keywords: *Accidents, Occupational ; Burns, Electric/*etiology ; California ; Humans ; Laboratories/organization & administration/*standards ; Male ; *Particle Accelerators
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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