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  • growth
  • kinetics
  • Springer  (7)
  • PANGAEA
  • 1970-1974  (7)
Collection
Publisher
  • Springer  (7)
  • PANGAEA
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 5 (1972), S. 111-115 
    ISSN: 1432-1041
    Keywords: Rifampicin ; kinetics ; multicompartmental analysis ; simultaneous serum urine and bile assessment ; one week treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To aid interpretation of the fall in the serum concentrations of rifampicin observed in the early phase of continuous treatment, the distribution of the antibiotic was assessed simultaneously in the serum, bile, and urine of patients treated for one week. Transfer constants between these compartments were calculated on the 1st and 7th day of treatment by multicompartmental kinetic analysis. — The results obtained suggest that the decrease in serum concentrations is due to enhanced biliary excretion; no significant change was observed in the amount of antibiotic excreted in the urine. The increased capacity of the liver to excrete rifampicin in bile might result from enzyme induction by the antibiotic in hepatocytes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of solution chemistry 3 (1974), S. 881-887 
    ISSN: 1572-8927
    Keywords: Binary aqueous mixtures ; solubilities ; kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A treatment which predicts the solubilities of gases in solvent mixtures is examined in the context of the analysis of kinetic data for reactions in aqueous mixtures. The treatment is qualitatively successful to some extent in resolving the effects of changes in the initial state of the reacting substrate in the activation parameters.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of pharmacokinetics and pharmacodynamics 2 (1974), S. 313-335 
    ISSN: 1573-8744
    Keywords: subcutaneous ; absorption ; kinetics ; local anesthetics ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The subcutaneous absorption kinetics of a homologous series of local anesthetics and lidocaine were studied under controlled pH conditions using a previously described in vivorat model. All local anesthetics exhibited biexponential absorption profiles suggesting accumulation into a tissue compartment. Evidence supporting this hypothesis was supplied by back-extraction of lidocaine from subcutaneous tissue into an acidic environment, by multiple dosing experiments, and by movement of compound into subcutaneous tissue of a postmortem rat preparation. A series of interanimal relationships were demonstrated between structure and parameters of a twocompartment open model. Particularly striking were the correlations between in vivopartition and tissue clearance and the octanolwater (pH 7.95)partition coefficients.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Biochemical genetics 12 (1974), S. 69-79 
    ISSN: 1573-4927
    Keywords: l-glycerol 3-phosphate dehydrogenase, purified ; inbred mice ; kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract l-Glycerol 3-phosphate dehydrogenase (E.C. 1.1.1.8) was purified from the muscle of BALB/cJ and C57BL/6J mice. The half-lives of the enzyme at 50 C were 6 and 33 min, respectively, for the BALB/cJ and C57BL/6J strains. Enzyme preparations from the two strains of mice were compared with respect to the following properties and found to be essentially indistinguishable: K m values for dihydroxyacetone phosphate, NADH, l-α-glycerophosphate, and NAD+; maximum velocity; competitive inhibition by inorganic phosphate; pH optimum; energy of activation; electrophoretic mobility; molecular weight and subunit molecular weight. From these data, it is concluded that the kinetic properties of the purified enzyme are not the factors responsible for the differences in activity found in crude homogenates of mouse tissues.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of solution chemistry 2 (1973), S. 217-238 
    ISSN: 1572-8927
    Keywords: Cation ; energies ; H. S. Frank ; M. Eigen ; R. G. Wilkins ; kinetics ; ligand substitution ; mechanism ; mixed solvents ; nonaqueous ; solvation ; solvent ; solvent structure ; solvent exchange ; transition metal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The role of the solvent in reactions involving ions is considered in relation to the structure of liquids. The rate constants and activation parameters for ligand substitutions at divalent transition metal cations in various solvents are compared with those for solvent exchanges. The differences are related to structural properties of the solvents, represented by their heats of evaporation and fluidities, and interpreted with the aid of a model developed from that of Frank and Wen. Water is not a typical solvent.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Oxidation of metals 8 (1974), S. 379-391 
    ISSN: 1573-4889
    Keywords: oxidation ; sulfidation ; kinetics ; parabolic rate law
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The conditions necessary to determine the oxidation kinetics of metals and alloys are discussed quantitatively, and a new method of calculating the rational rate constants was suggested. It was shown that the size and the shape of a metal sample has an effect on the kinetics of oxidation. Further, it was established that the values of the parabolic rate constants of corrosion, calculated from the empirical Pilling and Bedworth equation, contain a serious systematic error, if changes in the metallic core surface area during the oxidation process are neglected.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Biochemical genetics 11 (1974), S. 309-317 
    ISSN: 1573-4927
    Keywords: genetics ; rat ; kinetics ; brain MAO ; serum ChE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract This study was performed in order to delineate differences in kinetic enzyme characteristics of brain monoamine oxidase (MAO) and plasma cholinesterase (ChE) derived from the Walker-Walker (Fawn Hooded, FH) rat and from its putative ancestors, the Wistar (W) and Long-Evans (LE). As compared with the enzyme isolated from the other two strains, brain MAO from FH has both a higher V max and increased reaction rate at lower substrate concentrations. It may thus be described as a “more efficient” enzyme. This study confirms previous work which shows that plasma ChE activity of females is higher than that of males. Fluoride ion is a noncompetitive inhibitor of the Wistar ChE, is a competitive inhibitor of the FH enzyme, and has no effect on the LE enzyme. Dibucaine is a competitive inhibitor in all cases except one: ChE derived from the FH female is uncompetitively inhibited. A comparison of the inhibitor constants shows that FH ChE is more resistant to Dibucaine than is that of W, and that LE is the most sensitive. FH cholinesterase is twice as resistant to the action of fluoride as is the Wistar enzyme.
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