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  • Articles  (732)
  • Animals  (732)
  • 1975-1979  (732)
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  • Articles  (732)
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  • 1
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    Flatworm control of mosquito larvae in rice fields (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: We describe some flatworms (some in the genus Mesostoma) that kill mosquito larvae and may account for the variability in the population densities of Culex tarsalis and Anopheles freeborni in rice fields. When mosquito larvae brush against these worms, the larvae immediately become paralyzed and die. When C. tarsalis larvae are placed inside floating cages that exclude flatworms (50-micromter mesh), there is a fourfold increase in the their survival. Rice fields that have abundant mosquito populations lack flatworms. Most such fields have only recently been turned over to rice production, suggesting that the flatworms have difficulty dispersing to new fields but, once established, are able to overwinter and control mosquitoes for the subsequent years of rice production.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Case, T J -- Washino, R K -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1412-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/41321" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*methods ; Animals ; Anopheles/physiology ; California ; Culex/physiology ; Culicidae/*physiology ; Insect Control/*methods ; Larva ; *Oryza ; Platyhelminths/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A direct role of dopamine in the rat subthalamic nucleus and an adjacent intrapeduncular area (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: The subthalamic nucleus, a clinically important component of the extrapyramidal motor system, and a lateral area extending into the peduncle contain catecholamine terminals and dopamine receptors coupled to adenylate cyclase. In addition, dopamine agonists administered in vivo enhance glucose utilization in the region. Thus, neuronal function in this region is directly affected by dopamine and dopaminergic drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, L L -- Markman, M H -- Wolfson, L I -- Dvorkin, B -- Warner, C -- Katzman, R -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1416-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505015" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Animals ; Brain Mapping ; Catecholamines/pharmacology ; Dopamine/pharmacology ; Enzyme Activation/drug effects ; Extrapyramidal Tracts/*metabolism/ultrastructure ; Glucose/metabolism ; Male ; Mesencephalon/*metabolism ; Neurons/metabolism ; Rats ; Receptors, Dopamine/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Chlorpromazine and its metabolites alter polymerization and gelation of actin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Hepatic hydroxylated metabolites of chlorpromazine (10(-5)M to 10(-4)M), a frequently used phenothiazine tranquilizer, produce solid gel formation with filamentous actin, but the less toxic chlorpromazine sulfoxide metabolite does not. At higher concentrations (5 x 10(-4)M) chlorpromazine inhibits actin polymerization. These dose-response relationships parallel the drug's hepatic toxicity in vivo and suggest that interactions between chloropromazine or chlorpromazine metabolites and actin could be an underlying mechanism of cell injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elias, E -- Boyer, J L -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1404-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/574316" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/*metabolism ; Animals ; Chlorpromazine/*analogs & derivatives/*pharmacology ; Cytoskeleton/drug effects ; Dose-Response Relationship, Drug ; Gels ; Protein Binding/drug effects ; Rabbits ; Viscosity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morpholigic and physiologic characteristics of human insulin-dependent diabetes mellitus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Like, A A -- Rossini, A A -- Guberski, D L -- Appel, M C -- Williams, R M -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1421-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/388619" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antilymphocyte Serum/*therapeutic use ; *Autoimmune Diseases ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/*immunology/prevention & control/therapy ; Immunosuppression ; Islets of Langerhans/immunology ; Isoantibodies ; Lymphocytes/*immunology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Derived X chromosome in the turtle genus Staurotypus (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: C-banding, G-banding, and silver (Ag-AS) staining techniques reveal a distinctive sex chromosome system in the turtle Staurotypus salvinii. Unlike previously described systems in most other vertebrate groups in which the Y or W is derived and the homogametic sex represents the primitive condition, the reverse is true for S. salvinii. The X chromosome is derived; thus the homogametic sex (female) is more derived than the heterogametic sex. The male is intermediate between the female and the ancestral condition observed in other turtle species. Staurotypus does not confirm to the general model of sex chromosome evolution for diploid dioecious organisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sites, J W Jr -- Bickham, J W -- Haiduk, M W -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1410-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/92052" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Female ; Sex Chromosomes/*ultrastructure ; Silver ; Species Specificity ; Staining and Labeling ; Turtles/*anatomy & histology ; X Chromosome/*ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Pyruvate dehydrogenase activation in adipocyte mitochondria by an insulin-generated mediator from muscle (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Material in a chromatographic fraction from an extract of insulin-treated muscle stimulated pyruvate dehydrogenase activity in addipocyte mitochondria. This action was similar to insulin's activation of the enzyme in a plasma membrane-mitochondria mixture. Neither the chromatographic fraction nor insulin required adenosine triphosphate or magnesium ion (Mg2+), suggesting that both agents acted through a calcium-sensitive phosphatase. This fraction may contain a chemical mediator of insulin action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jarett, L -- Seals, J R -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1407-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505013" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/pharmacology ; Adipose Tissue/*enzymology ; Animals ; Cell Membrane/drug effects ; Enzyme Activation/drug effects ; Insulin/*pharmacology ; Magnesium/pharmacology ; Mitochondria/enzymology ; Muscles/drug effects/*physiology ; Pyruvate Dehydrogenase Complex/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Generation by insulin of a chemical mediator that controls protein phosphorylation and dephosphorylation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Deproteinized skeletal muscle extracts free of major nucleotides from control and insulin-treated rats were fractionated and assayed for inhibition of protein phosphorylation by cyclic adenosine monophosphate (AMP)-dependent and -independent protein kinases. A differential effect of insulin on a particular fraction was observed on cyclic AMP-dependent protein kinase but not on cyclic AMP-independent protein kinases. This fraction that inhibited cyclic AMP-dependent protein kinase also stimulated glycogen synthase phosphoprotein phosphatase. It is proposed that this fraction may contain a mediator substance generateed in the presence of insulin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Larner, J -- Galasko, G -- Cheng, K -- DePaoli-Roach, A A -- Huang, L -- Daggy, P -- Kellogg, J -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1408-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/228395" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cyclic AMP/metabolism ; Enzyme Activation/drug effects ; Glycogen-Synthase-D Phosphatase/*metabolism ; Insulin/*pharmacology ; Molecular Weight ; Muscle Proteins/isolation & purification/pharmacology ; Muscles/*drug effects ; Peptides/pharmacology ; Phosphoprotein Phosphatases/*metabolism ; *Protein Kinase Inhibitors ; Rats
    Print ISSN: 0036-8075
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  • 8
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    Vascular smooth muscle: aerobic glycolysis linked to sodium and potassium transport processes (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Under aerobic conditions, glucose is primarily catabolized by vascular smooth muscle to lactate, in spite of an adequate oxidative capacity. Although this is often considered to be indicative of some nonspecific metabolic insufficiency, there is evidence that aerobic glycolysis is specifically coupled to sodium and potassium transport processes, whereas oxidative metabolism is couple to contracticle energy requirements.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paul, R J -- Bauer, M -- Pease, W -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1414-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505014" target="_blank"〉PubMed〈/a〉
    Keywords: Aerobiosis ; Animals ; Arteries/*metabolism ; Biological Transport, Active/drug effects ; *Glycolysis/drug effects ; Lactates/metabolism ; Muscle Contraction/drug effects ; Muscle, Smooth/*metabolism ; Ouabain/pharmacology ; Oxygen Consumption/drug effects ; Potassium/*metabolism/pharmacology ; Sodium/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Clonal characteristics of experimentally induced "atherosclerotic" lesions in the hybrid hare (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: The female hybrid hare (Lepus timidus x Lepus europaeus) is heterozygous for electrophoretically separable, X-linked isoenzymes of glucose-6-phosphate dehydrogenase. The isoenzymes of this animal have been used as cellular markers in the study of the clonal origins of experimentally induced atherosclerotic lesions. Aortic lesions produced in the hybrid hare by feeding cholesterol and injuring the aortic wall with a catheter have been shown to have polyclonal characteristics and in this way are fundamentally different from atherosclerotic fibrous plaques in man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pearson, T A -- Dillman, J -- Williams, K J -- Wolff, J A -- Adams, R -- Solez, K -- Heptinstall, R H -- Malmros, H -- Sternby, N -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1423-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteriosclerosis/enzymology/*pathology ; Catheterization/methods ; Clone Cells/enzymology/*pathology ; Diet, Atherogenic ; *Disease Models, Animal ; Glucosephosphate Dehydrogenase/metabolism ; Isoenzymes/metabolism ; Rabbits
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: A variant of the MPC 11 cell line, M 311, produces a short immunoglobulin heavy chain. When compared with the parental gamma 2b heavy chain, M 311 was found to have a carboxyl terminal deletion comprising the CH3 domain. The COOH-terminal cyanogen bromide (CNBr) cleavage fragment of M 311 is identical to a corresponding segment ofa parental heavy chain CNBr fragment, with the exception of a substitution of asparagine for lysine at the COOH-terminal residue. This observation enabled prediction of both the parental DNA sequence in this region and the genetic mechanism which generated the variant, a frameshift followed by premature termination. This hypothesis is supported by studies of the DNA sequence of the MPC 11 gamma 2b constant region gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kenter, A L -- Birshtein, B K -- R21 AI106328/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1307-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Deletion ; Genes ; Immunoglobulin G/*genetics ; Immunoglobulin gamma-Chains/genetics ; Macromolecular Substances ; Melphalan/pharmacology ; Mice ; Mutation ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/genetics ; Peptide Chain Termination, Translational ; Plasmacytoma/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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