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  • Chemistry  (60,880)
  • AERODYNAMICS  (3,347)
  • 1980-1984  (35,806)
  • 1970-1974  (28,421)
Collection
Keywords
Publisher
Years
Year
  • 1
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    Rational approaches to chemotherapy: antisickling agents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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  • 3
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    Phase transition and crystal structure of the 37 degrees C form of cholesterol (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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  • 4
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    Cytochrome a3 structure in carbon monoxide-bound cytochrome oxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
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  • 5
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 6
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    Amphiphilic secondary structure: design of peptide hormones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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  • 7
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    Fourier transform mass spectrometry (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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  • 8
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    Studying enzyme mechanism by 13C nuclear magnetic resonance (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
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  • 9
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    What is the risk from chlorofluorocarbons? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Pyrolysis mass spectrometry of complex organic materials (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
    Print ISSN: 0036-8075
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  • 11
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    Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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  • 12
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    beta-Carotene: an unusual type of lipid antioxidant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-11
    Description: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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  • 13
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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  • 14
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    Phenylalanine transfer RNA: molecular dynamics simulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-16
    Description: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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  • 15
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    Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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  • 16
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    Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-15
    Description: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Keywords: Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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  • 18
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    DNA-binding proteins (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-09
    Description: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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  • 19
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    A nitrogen pressure of 50 atmospheres does not prevent evolution of hydrogen by nitrogenase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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  • 20
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    Nonvolatile mutagens in drinking water: production by chlorination and destruction by sulfite (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheh, A M -- Skochdopole, J -- Koski, P -- Cole, L -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):90-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985746" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Chloramines ; Chlorine ; Mutagens/*analysis ; Salmonella typhimurium/genetics ; Sulfites ; Water Pollutants/*analysis ; Water Pollutants, Chemical/*analysis ; Water Supply/*analysis
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  • 21
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    Automated synthesis of gene fragments (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-16
    Description: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Keywords: Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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  • 22
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    Chitin: New facets of research (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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  • 23
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    DNA sequencing and gene structure (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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  • 24
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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    Reversible chemical modification of the scrapie agent (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 26
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    Nonenzymatic browning in vivo: possible process for aging of long-lived proteins (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
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    The National Science Foundation looks to the future (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-03-13
    Description: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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  • 28
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    New chemistry of an old molecule: cis-[Pt(NH3)2Cl2] (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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  • 29
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    The chemistry of vision (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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  • 30
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    Antiviral agents (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Keywords: Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
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  • 31
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    Metastable species of hemoglobin: room temperature transients and cryogenically trapped intermediates (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-06
    Description: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
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  • 32
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    Irreversible ligands with high selectivity toward delta and mu opiate receptors (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Keywords: Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
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  • 33
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    Trace chemistries of fire: a source of chlorinated dioxins (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bumb, R R -- Crummett, W B -- Cutie, S S -- Gledhill, J R -- Hummel, R H -- Kagel, R O -- Lamparski, L L -- Luoma, E V -- Miller, D L -- Nestrick, T J -- Shadoff, L A -- Stehl, R H -- Woods, J S -- New York, N.Y. -- Science. 1980 Oct;210(4468):385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159682" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; *Dioxins/analysis ; *Fires ; Power Plants ; Smoke/analysis ; Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis ; Vehicle Emissions/analysis ; Water Pollutants, Chemical/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 34
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    Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-25
    Description: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 35
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    Curved-flow, rolling-flow, and oscillatory pure-yawing wind-tunnel test methods for determination of dynamic stability derivatives (1981)
    In:  CASI
    Details
    Publication Date: 2011-10-14
    Description: The test capabilities of the Stability Wind Tunnel of the Virginia Polytechnic Institute and State University are described, and calibrations for curved and rolling flow techniques are given. Oscillatory snaking tests to determine pure yawing derivatives are considered. Representative aerodynamic data obtained for a current fighter configuration using the curved and rolling flow techniques are presented. The application of dynamic derivatives obtained in such tests to the analysis of airplane motions in general, and to high angle of attack flight conditions in particular, is discussed.
    Keywords: AERODYNAMICS
    Type: AGARD Dyn. Stability Parameters; 13 p
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  • 36
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    Application of advanced aerodynamics to future transport aircraft (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Applications of supercritical airfoils to transport aircraft designs
    Keywords: AERODYNAMICS
    Type: NASA AIRCRAFT SAFETY AND OPERATING PROBL., VOL. 1 1971; P 165-176
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  • 37
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    Aircraft response to the wing trailing vortices generated by large jet transports (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Flight tests for evaluating effect of wing-tip vortex wake generated by large jet transports on smaller aircraft
    Keywords: AERODYNAMICS
    Type: NASA AIRCRAFT SAFETY AND OPERATING PROBL., VOL. 1 1971; P 115-126
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  • 38
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    Progress report on wing-trailing-vortex studies (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Effect of wing-tip vortex wakes generated by large jet transport aircraft on smaller airplanes
    Keywords: AERODYNAMICS
    Type: NASA AIRCRAFT SAFETY AND OPERATING PROBL., VOL. 1 1971; P 101-113
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  • 39
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    Gust alleviation (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Alleviation of lateral and longitudinal gust effects on aircraft
    Keywords: AERODYNAMICS
    Type: PERFORMANCE AND DYN. OF AEROSPACE VEHICLES 1971; P 505-553
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  • 40
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    Effects of aeroelasticity on static aerodynamic derivatives (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Effects of aeroelasticity on static longitudinal aerodynamic derivatives
    Keywords: AERODYNAMICS
    Type: PERFORMANCE AND DYN. OF AEROSPACE VEHICLES 1971; P 375-438
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  • 41
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    Design of bodies for low drag and high performance in practical hypersonic flight (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Minimizing drag and increasing performance of optimum shapes at hypersonic flight
    Keywords: AERODYNAMICS
    Type: PERFORMANCE AND DYN. OF AEROSPACE VEHICLES 1971; P 103-174
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  • 42
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    Methods of obtaining stability derivatives (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Least squares method and iteration technique for obtaining aerodynamic stability derivatives
    Keywords: AERODYNAMICS
    Type: PERFORMANCE AND DYN. OF AEROSPACE VEHICLES 1971; P 71-101
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  • 43
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    Analysis of the flow field of a jet in a subsonic crosswind (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Jet induced flow field effects on V/STOL aircraft in subsonic transition flight
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 683-702
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  • 44
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    Procedures for designing supersonic bodies of revolution from prescribed surface pressure distributions (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Iterative method for designing supersonic body of revolution from surface pressure distribution
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 75-84
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  • 45
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    Ground-wind-load considerations for space shuttle vehicles (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Ground wind loads on reusable space shuttles
    Keywords: AERODYNAMICS
    Type: SPACE TRANSPORTATION SYSTEM TECHNOL. SYMP., VOL. 2 JUL. 1970; P 143-160
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  • 46
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    Buffet and aerodynamic noise (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Space shuttle buffeting and aerodynamic noise
    Keywords: AERODYNAMICS
    Type: SPACE TRANSPORTATION SYSTEM TECHNOL. SYMP., VOL. 2 JUL. 1970; P 238-247
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  • 47
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    Theoretical investigation of ducted fan interference for transport-type aircraft (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Ducted fan interference analysis for transport aircraft
    Keywords: AERODYNAMICS
    Type: NASA, WASHINGTON ANAL. METHODS IN AIRCRAFT AERODYN. 1970; P 703-719
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  • 48
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    Time-dependent numerical method for treating complicated blunt-body flow fields (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Time-dependent numerical method for blunt body flow field solutions
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 177-195
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  • 49
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    A critical evaluation of analytic methods for predicting laminar-boundary-layer shock-wave interaction (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Prediction methods for boundary layer and flow field characteristics in shock wave-boundary layer interaction
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 515-539
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  • 50
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    A numerical method for computing three-dimensional viscous supersonic flow fields about slender bodies (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Numerical analysis of three dimensional viscous supersonic flow fields about slender bodies
    Keywords: AERODYNAMICS
    Type: NASA, WASHINTON ANAL. METHODS IN AIRCRAFT AERODYN. 1970; P 265-321
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  • 51
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    In-flight aeroacoustic environments on prospective space shuttle vehicles (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The problem of in-flight aerodynamic noise has been studied by reliable estimates of full scale surface-pressure fluctuations from scale model tests in wind tunnels. Scaling relationships have been verified, and many details of the fluctuating pressure characteristics such as spatial correlation and convection velocities are understood. The effects of the wind tunnel environmental turbulence and noise have also been investigated sufficiently so that threshold levels of usable data are known.
    Keywords: AERODYNAMICS
    Type: NASA Space Shuttle Technol. Conf.; p 71-96
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  • 52
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    Optimization of supersonic inlets using the method of characteristics (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Method of characteristics for computerized design of optimal supersonic inlets
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 569-581
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  • 53
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    A new method for calculating near and far field pressure about arbitrary configurations (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Aerodynamic method of characteristics for pressure field calculations about wing-body combinations
    Keywords: AERODYNAMICS
    Type: L METHODS IN AIRCRAFT AERODYN. 1970; P 215-227
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  • 54
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    The analysis of propeller-wing flow interaction (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Numerical analysis of propeller-wing flow interaction with slipstreams
    Keywords: AERODYNAMICS
    Type: NASA, WASHINGTON ANAL. METHODS IN AIRCRAFT AERODYN. 1970; P 721-742
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  • 55
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    Wind tunnel simulation of ground wind shear and turbulence spectra with possible application to space shuttle launch problems (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Wind tunnel simulation of ground wind shear and turbulence spectra and application to space shuttle launching
    Keywords: AERODYNAMICS
    Type: NASA. LEWIS RES. CENTER SPACE TRANSPORTATION SYSTEM TECHNOL. SYMP., VOL. 2 JUL. 1970; P 161-175
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  • 56
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    Theoretical studies of vortex flow on slender wing-body combinations (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Lift and pressure distribution calculations for winged body with leading edge vortices
    Keywords: AERODYNAMICS
    Type: NASA, WASHINGTON ANAL. METHODS IN AIRCRAFT AERODYN. 1970; P 113-129
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  • 57
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    Finite-difference analysis of the compressible turbulent boundary layer on a blunt swept slab with leading-edge blowing (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Finite difference solution for compressible turbulent boundary layer equations of swept slab with leading edge blowing
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 417-472
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  • 58
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    Recent advances in research on compressible turbulent boundary layers (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Review of prediction methods for compressible turbulent boundary layers
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 355-416
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  • 59
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    An analysis of finite-difference techniques applied to equations governing convective transfer (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Finite difference analysis of hyperbolic partial differential equations
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 245-264
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  • 60
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    Prediction of supersonic and hypersonic inlet flow fields (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Computer programs for predicting flow field properties in supersonic and hypersonic inlets
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 583-595
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  • 61
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    Improvement of wing-body interference theory for hypersonic speeds (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Wing-body interference theory for calculating lift slope and stability at hypersonic speed
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 101-111
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  • 62
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    Some recent developments in subsonic lifting-surface theory (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Numerical lifting surface theory with spanwise distribution of control points
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 1-35
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  • 63
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    Application of the method of characteristics to noncircular bodies at angle of attack (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Method of characteristics for flow field analysis on elliptical winged body
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 159-176
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  • 64
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    The use of finite element methods for predicting the aerodynamics of wing-body combinations (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Finite element method for predicting aerodynamic characteristics of wing-body combinations
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 37-51
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  • 65
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    Potential flow solutions for inlets of VTOL lift fans and engines (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Potential flow solution for VTOL inlets in static and crossflow operation
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 659-681
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  • 66
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    Methods of analyzing propeller and rotor boundary layers with crossflow (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Analysis of secondary flow effects in propeller and rotor boundary layers
    Keywords: AERODYNAMICS
    Type: NASA, WASHINGTON ANAL. METHODS IN AIRCRAFT AERODYN. 1970; P 473-514
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  • 67
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    A new method for analysis of transonic flow (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Finite difference method for transonic flow solution in axial stator
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 597-621
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  • 68
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    A method for analyzing the interaction of an oblique shock wave and a boundary layer (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Method of characteristics for calculating oblique shock wave interaction with turbulent boundary layer
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 541-567
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  • 69
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    A critical evaluation of panel flutter aerodynamics (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Aerodynamic forces in supersonic panel flutter
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 335-353
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  • 70
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    An analysis of Coanda jet flows (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Static laminar Coanda jet flow around circular cylinder with external flow entrainment
    Keywords: AERODYNAMICS
    Type: NASA, WASHINGTON ANAL. METHODS IN AIRCRAFT AERODYN. 1970; P 197-214
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  • 71
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    Empirical method for estimating pressures on elliptic cones (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Correlation method for estimating pressure distribution over elliptic supersonic cones
    Keywords: AERODYNAMICS
    Type: L. METHODS IN AIRCRAFT AERODYN. 1970; P 85-99
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  • 72
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    Calculative techniques for transonic flows (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Calculation methods for predicting transonic aerodynamic characteristics of wing-body combinations
    Keywords: AERODYNAMICS
    Type: NASA, WASHINGTON ANAL. METHODS IN AIRCRAFT AERODYN. 1970; P 53-73
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  • 73
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    Flutter and unsteady lift theory (1971)
    In:  CASI
    Details
    Publication Date: 2009-11-16
    Description: Aeroelasticity and unsteady flow problems of aircraft
    Keywords: AERODYNAMICS
    Type: PERFORMANCE AND DYN. OF AEROSPACE VEHICLES 1971; P 289-374
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  • 74
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    The relevance of recent advances in unsteady aerodynamics to the space shuttle program (1970)
    In:  CASI
    Details
    Publication Date: 2009-11-17
    Description: Prediction of steady and unsteady airloads on space shuttles
    Keywords: AERODYNAMICS
    Type: NASA. LEWIS RES. CENTER SPACE TRANSPORTATION SYSTEM TECHNOL. SYMP., VOL. 2 JUL. 1970; P 223-237
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  • 75
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    Summary and future plans (1972)
    In:  CASI
    Details
    Publication Date: 2004-12-03
    Keywords: AERODYNAMICS
    Type: Supercritical Wing Technol.: A Report on Flight Evaluation; p 121-133
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  • 76
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    Piloting and operational aspets of the F-8 supercritical wing airplane (1972)
    In:  CASI
    Details
    Publication Date: 2004-12-03
    Keywords: AERODYNAMICS
    Type: Supercritical Wing Technol.: A Report on Flight Evaluation; p 97-110
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  • 77
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    Status of the F-8 supercritical wing program (1972)
    In:  CASI
    Details
    Publication Date: 2004-12-03
    Keywords: AERODYNAMICS
    Type: Supercritical Wing Technol.: A Report on Flight Evaluation; p 49-58
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  • 78
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    F-8 supercritical wing pressure distribution evaluation (1972)
    In:  CASI
    Details
    Publication Date: 2004-12-03
    Keywords: AERODYNAMICS
    Type: Supercritical Wing Technol.: A Report on Flight Evaluation; p 71-84
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  • 79
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    Buffet characteristics of the F-8 supercritical wing airplane (1972)
    In:  CASI
    Details
    Publication Date: 2004-12-03
    Keywords: AERODYNAMICS
    Type: Supercritical Wing Technol.: A Report on Flight Evaluation; p 85-96
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  • 80
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    The NASA supercritical airfoil and its application to swept wings (1972)
    In:  CASI
    Details
    Publication Date: 2004-12-03
    Keywords: AERODYNAMICS
    Type: Supercritical Wing Technol.: A Report on Flight Evaluation; p 1-12
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  • 81
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    Evolution of the F-8 supercritical wing configuration (1972)
    In:  CASI
    Details
    Publication Date: 2004-12-03
    Keywords: AERODYNAMICS
    Type: Supercritical Wing Technol.: A Report on Flight Evaluation; p 35-48
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  • 82
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    Preliminary lift and drag characteristics of the F-8 supercritical wing airplane (1973)
    In:  CASI
    Details
    Publication Date: 2004-12-03
    Keywords: AERODYNAMICS
    Type: its Supercritical Wing Technol.: A Report on Flight Evaluation; p 59-70
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  • 83
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    In-flight lift and drag measurements on a first generation jet transport equipped with winglets (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A KC-135A aircraft equipped with wing tip winglets was flight tested to demonstrate and validate the potential performance gain of the winglet concept as predicted from analytical and wind tunnel data. Flight data were obtained at cruise conditions for Mach numbers of 0.70, 0.75, and 0.80 at a nominal altitude of 36,000 ft. and winglet configurations of 15 deg cant/-4 deg incidence, 0 deg cant/-4 deg incidence, and baseline. For the Mach numbers tested the data show that the addition of winglets did not affect the lifting characteristics of the wing. However, both winglet configurations showed a drag reduction over the baseline configuration, with the best winglet configuration being the 15 deg cant/-4 deg incidence configuration. This drag reduction due to winglets also increased with increasing lift coefficient. It was also shown that a small difference exists between the 15 deg cant/-4 deg incidence flight and wind tunnel predicted data. This difference was attributed to the pillowing of the winglet skins in flight which would decrease the winglet performance.
    Keywords: AERODYNAMICS
    Type: KC-135 Winglet Program Rev.; p 103-116
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  • 84
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    KC-135 winglet program overview (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A joint NASA/USAF program was conducted to accomplish the following objectives: (1) evaluate the benefits that could be achieved from the application of winglets to KC-135 aircraft; and (2) determine the ability of wind tunnel tests and analytical analysis to predict winglet characteristics. The program included wind-tunnel development of a test winglet configuration; analytical predictions of the changes to the aircraft resulting from the application of the test winglet; and finally, flight tests of the developed configuration. Pressure distribution, loads, stability and control, buffet, fuel mileage, and flutter data were obtained to fulfill the objectives of the program.
    Keywords: AERODYNAMICS
    Type: KC-135 Winglet Program Rev.; p 1-46
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  • 85
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    KC-135 wing and winglet flight pressure distributions, loads, and wing deflection results with some wind tunnel comparisons (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A full-scale winglet flight test on a KC-135 airplane with an upper winglet was conducted. Data were taken at Mach numbers from 0.70 to 0.82 at altitudes from 34,000 feet to 39,000 feet at stabilized flight conditions for wing/winglet configurations of basic wing tip, 15/-4 deg, 15/-2 deg, and 0/-4 deg winglet cant/incidence. An analysis of selected pressure distribution and data showed that with the basic wing tip, the flight and wind tunnel wing pressure distribution data showed good agreement. With winglets installed, the effects on the wing pressure distribution were mainly near the tip. Also, the flight and wind tunnel winglet pressure distributions had some significant differences primarily due to the oilcanning in flight. However, in general, the agreement was good. For the winglet cant and incidence configuration presented, the incidence had the largest effect on the winglet pressure distributions. The incremental flight wing deflection data showed that the semispan wind tunnel model did a reasonable job of simulating the aeroelastic effects at the wing tip. The flight loads data showed good agreement with predictions at the design point and also substantiated the predicted structural penalty (load increase) of the 15 deg cant/-2 deg incidence winglet configuration.
    Keywords: AERODYNAMICS
    Type: KC-135 Winglet Program Rev.; p 47-102
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  • 86
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    Status of advanced airfoil tests in the Langley 0.3-meter transonic cryogenic tunnel (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A joint NASA/U.S. industry program to test advanced technology airfoils in the Langley 0.3-meter Transonic Tunnel (TCT) was formulated under the Langley ACEE Project Office. The objectives include providing U.S. industry an opportunity to compare their most advanced airfoils to the latest NASA designs by means of high Reynolds number tests in the same facility. At the same time, industry would again experience in the design and construction of cryogenic test techniques. The status and details of the test program are presented. Typical aerodynamic results obtained, to date, are presented at chord Reynolds number up to 45 x 10(6) and are compared to results from other facilities and theory. Details of a joint agreement between NASA and the Deutsche Forschungs- und Versuchsantalt fur Luft- and Raumfahrt e.V. (DFVLR) for tests of two airfoils are also included. Results of these tests will be made available as soon as practical.
    Keywords: AERODYNAMICS
    Type: Advan. Aerodyn.: Selected NASA Res.; p 37-53
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  • 87
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    Component testing for dynamic model verification (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Dynamic model verification is the process whereby an analytical model of a dynamic system is compared with experimental data, adjusted if necessary to bring it into agreement with the data, and then qualified for future use in predicting system response in a different dynamic environment. These are various ways to conduct model verification. The approach taken here employs Bayesian statistical parameter estimation. Unlike curve fitting, whose objective is to minimize the difference between some analytical function and a given quantity of test data (or curve), Bayesian estimation attempts also to minimize the difference between the parameter values of that funciton (the model) and their initial estimates, in a least squares sense. The objectives of dynamic model verification, therefore, are to produce a model which: (1) is in agreement with test data; (2) will assist in the interpretation of test data; (3) can be used to help verify a design; (4) will reliably predict performance; and (5) in the case of space structures, will facilitate dynamic control.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Recent Experiences in Multidisciplinary Analysis and Optimization, Part 2; 15 p
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  • 88
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    Post and a random-walk search mode (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Multidisciplinary analysis often requires optimization of nonlinear systems that are subject to constraints. Trajectory optimization is one example of this situation. The Program to Optimize Simulated Trajectories (POST) was used successfully for a number of problems. The purpose is to describe POST and a new optimization approach that has been incorporated into it. Typical uses of POST will also be illustrated. The projected-gradient approach to optimization is the preferred option in POST and is discussed. A new approach to optimization, the random-walk approach, is described, and results with the random-walk approach are presented.
    Keywords: AERODYNAMICS
    Type: Recent Experiences in Multidisciplinary Analysis and Optimization, Part 2; 23 p
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  • 89
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    Wall interference measurements for three-dimensional models in transonic wind tunnels: Experimental difficulties (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The purpose is not to provide a detailed discussion of several wall interference experiments, but rather to use these experiments (recently accomplished in the Boeing Transonic Wind Tunnel (BTWT) to illustrate the problems associated with many of the measurements required by current wall interference assessment/correction (WIAC) procedures. The wall correction to lift is emphasized. It is shown that, because conventional tunnels and relatively small models continue to be used, the flow field or flow boundary measurements to be made impose severe requirements on the experiment itself. In some cases, existing instrumentation and test techniques may not be adequate to obtain the data accuracies needed.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 21-42
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  • 90
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    Adaptation of a four-wall interference assessment/correction procedure for airfoil tests in the 0.3-m TCT (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Based upon limited, initial observations of wall interference corrections obtained for one airfoil test, there is a need for assessing the upstream flow direction. If there is no direct measurement then a two-pass correction procedure similar to the one described here is required. Questions have arisen pertaining to the correct interpretation of the pressure coefficients measured on the slats of a slotted tunnel wall, the interpretation of just what the calculated equivalent body encompasses or should include, and what can or should be considered as quantitative criteria for data correctability. Further studies using this modified procedure will address these questions. Hopefully, a meaningful WIAC procedure can be validated for the airfoil tests in the 0.3-m TCT.
    Keywords: AERODYNAMICS
    Type: Wind Tunnel Wall Interference Assessment and Correction, 1983; p 393-414
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  • 91
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    Some experience with Barnwell-Sewall type correction to two-dimensional airfoil data (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A series of airfoils were tested in the Langley 0.3-Meter Transonic Cryogenic Tunnel (TCT) at Reynolds numbers from 2 to 50 million. The 0.3-m TCT is equipped with Barnwell slots designed to minimize blockage due to the tunnel flow and ceiling. This design suggests that sidewall corrections for blockage is needed, and that a lifting airfoil produces a change in angle of attack. Sidewall correction methods were developed for subsonic and subsonic-transonic flow. Comparisons of theory with experimental data obtained in the 0.3-m TCT for two airfoils, the British NPL 9510 and the German R-4 are presented. The NPL 9510 was tested as part of the NASA/United Kingdom Joint Aeronautical Program and R-4 was tested as part f the DFVLR/NASA Advanced Airfoil Research Program. For the NPL 9510 airfoil, only those test points that one would anticipate being difficult to predict theoretically are presented.
    Keywords: AERODYNAMICS
    Type: Wind Tunnel Wall Interference Assessment and Correction, 1983; p 375-392
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  • 92
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    Experiences with a high-blockage model tested in the NASA Ames 12-foot pressure wind tunnel (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Representation of the flow around full-scale ships was sought in the subsonic wind tunnels in order to a Hain Reynolds numbers as high as possible. As part of the quest to attain the largest possible Reynolds number, large models with high blockage are used which result in significant wall interference effects. Some experiences with such a high blockage model tested in the NASA Ames 12-foot pressure wind tunnel are summarized. The main results of the experiment relating to wind tunnel wall interference effects are also presented.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 345-360
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  • 93
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    An inerference assessment approach for a three-dimensional slotted tunnel with sparse wall pressure data (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The various procedures referred to as wall interference assessment and correction procedures presume the existence of a surface distribution of data (usually static pressure) measured over a surface on or near the tunnel walls for each test point to be assessed. An alternative approach in which a reasonably sophisticated computer model of the test section flow would be fitted parametrically to a sparse set of measured data is presented. The measurements provides line distributions of static pressure near the center lines of the top, side and bottom walls. The development of a test section model incorporating explicit recognition of discrete slots of finite length with controlled flow reentry into the solid wall downstream portion of the tunnel is shown.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center. Wind Tunnel Wall Interference Assessment and Correction, 1983; p 323-334
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  • 94
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    EBF noise tests with engine under-the-wing and over-the-wing configurations (1972)
    In:  CASI
    Details
    Publication Date: 2006-03-27
    Description: Noise tests of externally blown flaps with the engine under the wing and engine over the wing configurations were conducted. Flap noise data obtained on a TF-34 aircraft are discussed. Noise data obtained during a free-jet forward-speed-effect analysis are presented. Noise sources associated with upper surface flap blowing are described. Results of a small scale configuration screening study and some large scale model test data are analyzed. The noise data for the engine over wing configurations are compared with the engine under the wing configurations.
    Keywords: AERODYNAMICS
    Type: STOL Technol.; p 455-473
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  • 95
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    Flap noise generation and control (1972)
    In:  CASI
    Details
    Publication Date: 2006-03-27
    Description: The characteristics of aerodynamic noise generated by the interaction of an airstream with a flap surface are discussed. The location and behavior of various noise sources were investigated to determine optimal quieting techniques. A schematic diagram of the jet-flap concepts being considered for integrated-powered-lift systems for short takeoff aircraft is shown. Each of the concepts has in common high velocity turbulent air flowing over relatively rigid surfaces with resultant production of interaction noise. The nature, location, and control of noise sources which involve the interactions of air flows with airfoil surfaces are examined.
    Keywords: AERODYNAMICS
    Type: STOL Technol.; p 413-426
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  • 96
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    Acoustic characteristics of large-scale STOL models at forward speed (1972)
    In:  CASI
    Details
    Publication Date: 2006-03-27
    Description: Wind-tunnel investigations of the acoustic characteristics of the externally blown jet flap (EBF) and augmentor wing STOL concepts are discussed. The large-scale EBF model was equipped with a triple-slotted flap blown by four JT15D turbofan engines with circular, coannular exhaust nozzles. The large-scale augmentor wing model was equipped with an unlined augmentor blown by a slot primary nozzle. The effects of airspeed and angle of attack on the acoustics of the EBF were small. Flap deflection had a greater effect on the acoustics of the augmentor wing than did airspeed. The total sound power was also significantly higher for landing indicating that turning in the augmentor generated acoustic energy. Airspeed produced a small aft shift in acoustic directivity with no significant change in the peak perceived noise levels or sound power levels. Small-scale research of the acoustics for the augmentor wing has shown that by blowing an acoustically treated augmentor with a lobed primary nozzle, the 95-PNdb noise level goal can be achieved or surpassed.
    Keywords: AERODYNAMICS
    Type: STOL Technol.; p 443-454
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  • 97
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    Externally blown flap impingement noise (1972)
    In:  CASI
    Details
    Publication Date: 2006-03-27
    Description: Tests of the noise produced by the impingement of the jet exhaust on the wing and flap for an externally blown flap system were conducted with a CF700 turbofan engine and an F-111B wing panel. The noise produced with a daisy nozzle installed on the engine was greater than that produced by a conical nozzle at the same thrust. The presence of the wing next to the test nozzles increased the noise, as did increasing the flap deflection angle. Compared with the conical nozzle, the daisy nozzle produced slightly less noise at a flap deflection of 60 deg but produced more noise at the lower flap deflections tested. Tests showed that the single-slotted flap deflected 60 deg, produced less noise than the double-slotted flaps. Also, maintaining the maximum distance between the exit nozzle and flap system resulted in a minor reduction in noise.
    Keywords: AERODYNAMICS
    Type: STOL Technol.; p 427-441
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  • 98
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    Externally blown flap dynamic loads (1973)
    In:  CASI
    Details
    Publication Date: 2006-03-27
    Description: Some of the principal results obtained in three series of measurements of fluctuating surface pressures induced on externally blown flaps by jet impingment are presented. Large- and small-scale models and hot- and cold-flow tests are considered. The discussion sets forth scaling parameters and consistent features of the root-mean-square values and spectra of the loading. Implications of these results with regard to sonic fatigue are indicated.
    Keywords: AERODYNAMICS
    Type: STOL Technol.; p 131-142
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  • 99
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    Survey of wing and flap lower-surface temperatures and pressures during full-scale ground tests of an externally blown flap system (1972)
    In:  CASI
    Details
    Publication Date: 2006-03-27
    Description: Full-scale ground tests of an externally blown flap system were made using the wing of an F-111B airplane and a CF700 engine. Pressure and temperature distributions were determined on the undersurface of the wing, vane, and flap for two engine exhaust nozzles (conical and daisy) at several engine power and engine/wing positions. The tests were made with no airflow over the wing. The leading-edge wing sweep angle was fixed at 26 deg, the angle of incidence between the engine and the wing was fixed at 3 deg, and the tests were conducted with the flap retracted, extended and deflected 35 deg, and extended and deflected 60 deg. The integrated local pressures on the undersurface of the flap produced loads approximately three times as great at the 60 deg flap position as at the 35 deg flap position. With both nozzle configurations, more than 90 percent of the integrated pressure loads were contained within plus or minus 20 percent of the flap span centered around the engine exhaust centerline. The maximum temperature recorded on the flaps was 218 C (424 F) for the conical nozzle and 180 C (356 F) for the daisy nozzle.
    Keywords: AERODYNAMICS
    Type: STOL Technol.; p 143-156
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  • 100
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    Simulator evaluation of the flying qualities of externally blown flap and augmentor wing transport configurations (1972)
    In:  CASI
    Details
    Publication Date: 2006-03-27
    Description: Concurrent simulations of powered-lift STOL transport aircraft having either an externally blown flap configuration or an augmentor wing configuration were conducted. The following types of simulators of varying sophistication were used: (1) a simple fixed-base simulation with a simple visual display, (2) a more complex fixed-base simulation using a realistic transport cockpit and a high-quality visual display, and (3) a six-degree-of-freedom motion simulator that had a realistic transport cockpit and a sophisticated visual display. The unaugmented flying qualities determined from these simulations were rated as unacceptable for both the externally blown flap and augmentor wing configurations. The longitudinal, lateral-directional, and single-engine-failure characteristics were rated satisfactory with extensive augmentation, including pitch and roll command systems, flight-path (or speed) augmentation, turn coordination, and effective yaw damping. However, the flare and landing characteristics from any approach glide-path angle in excess of 4 deg were rated as unsatisfactory but acceptable.
    Keywords: AERODYNAMICS
    Type: STOL Technol.; p 157-800
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