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  • American Association for the Advancement of Science (AAAS)  (13,320)
  • 1990-1994  (13,320)
Collection
Keywords
Publisher
Years
Year
  • 1
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    Sea-Surface Temperature from Coral Skeletal Strontium/Calcium Ratios (1992)
    American Association for the Advancement of Science (AAAS)
    In:  Science, 257 (5070). pp. 644-647.
    Details
    Publication Date: 2019-03-13
    Description: Seasonal records of tropical sea-surface temperature (SST) over the past 10(5) years can be recovered from high-precision measurements of coral strontium/calcium ratios with the use of thermal ionization mass spectrometry. The temperature dependence of these ratios was calibrated with corals collected at SST recording stations and by (18)O/(16)O thermometry. The results suggest that mean monthly SST may be determined with an apparent accuracy of better than 0.5 degrees C. Measurements on a fossil coral indicate that 10,200 years ago mean annual SSTs near Vanuatu in the southwestern Pacific Ocean were about 5 degrees C colder than today and that seasonal variations in SST were larger. These data suggest that tropical climate zones were compressed toward the equator during deglaciation.
    Type: Article , PeerReviewed
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  • 2
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    Cephalopodologie (1990)
    American Association for the Advancement of Science (AAAS)
    In:  Science, 248 . pp. 898-899.
    Details
    Publication Date: 2017-02-15
    Type: Article , PeerReviewed
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  • 3
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    Global Climate Change and Intensification of Coastal Ocean Upwelling (1990)
    American Association for the Advancement of Science (AAAS)
    In:  Science, 247 (4939). pp. 198-201.
    Details
    Publication Date: 2017-01-04
    Description: A mechanism exists whereby global greenhouse warning could, by intensifying the alongshore wind stress on the ocean surface, lead to acceleration of coastal upwelling. Evidence from several different regions suggests that the major coastal upwelling systems of the world have been growing in upwelling intensity as greenhouse gases have accumulated in the earth's atmosphere. Thus the cool foggy summer conditions that typify the coastlands of northern California and other similar upwelling regions might, under global warming, become even more pronounced. Effects of enhanced upwelling on the marine ecosystem are uncertain but potentially dramatic.
    Type: Article , PeerReviewed
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  • 4
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    Causes of Decadal Climate Variability over the North Pacific and North America (1994)
    American Association for the Advancement of Science (AAAS)
    In:  Science, 266 (5185). pp. 634-637.
    Details
    Publication Date: 2016-09-09
    Description: The cause of decadal climate variability over the North Pacific Ocean and North America is investigated by the analysis of data from a multidecadal integration with a state-of-the-art coupled ocean-atmosphere model and observations. About one-third of the low-frequency climate variability in the region of interest can be attributed to a cycle involving unstable air-sea interactions between the subtropical gyre circulation in the North Pacific and the Aleutian low-pressure system. The existence of this cycle provides a basis for long-range climate forecasting over the western United States at decadal time scales.
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  • 5
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    A Two-Tiered Approach to Long-Range Climate Forecasting (1993)
    American Association for the Advancement of Science (AAAS)
    In:  Science, 261 (5124). pp. 1026-1029.
    Details
    Publication Date: 2016-09-09
    Description: Long-range global climate forecasts were made by use of a model for predicting a tropical Pacific sea-surface temperature (SST) in tandem with an atmospheric general circulation model. The SST is predicted first at long lead times into the future. These ocean forecasts are then used to force the atmospheric model and so produce climate forecasts at lead times of the SST forecasts. Prediction of seven large climatic events of the 1970s to 1990s by this technique are in good agreement with observations over many regions of the globe.
    Type: Article , PeerReviewed
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  • 6
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    ATP-dependent nucleosome reconfiguration and transcriptional activation from preassembled chromatin templates (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: GAL4-VP16-mediated nucleosome reconfiguration and transcriptional activation were observed with preassembled chromatin templates that contained regular and physiological nucleosome spacing. Both processes were dependent on adenosine triphosphate (ATP), although binding of GAL4-VP16 to the chromatin was ATP-independent. Factor-mediated nucleosome reconfiguration was not, however, sufficient for transcriptional activation. These experiments recreate in vitro the active participation of nucleosomal cores in the regulation of transcription that occurs in vivo, and they suggest a multistep pathway for transcriptional activation in which factor- and ATP-dependent nucleosome reconfiguration is followed by facilitation by the DNA-bound activator of transcription from the repressed chromatin template.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pazin, M J -- Kamakaka, R T -- Kadonaga, J T -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):2007-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California, San Diego, La Jolla 92093-0347.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801129" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/*metabolism ; Animals ; Chromatin/chemistry/*metabolism ; DNA/metabolism ; DNA-Binding Proteins ; Drosophila ; Fungal Proteins/metabolism ; Models, Genetic ; Nucleosomes/chemistry/*metabolism ; *Saccharomyces cerevisiae Proteins ; Templates, Genetic ; Trans-Activators/metabolism ; Transcription Factors/metabolism ; *Transcriptional Activation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Polymerase structures and mechanism (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pelletier, H -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):2025-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801132" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Biological Evolution ; Catalysis ; DNA Polymerase I/*chemistry/metabolism ; Protein Structure, Secondary
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Theorists make a bid to eliminate black holes (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flam, F -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1945.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836512" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Molecule of the year: the DNA repair enzyme (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koshland, D E Jr -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1925.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801114" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA Damage ; *DNA Ligases ; *DNA Repair ; DNA Replication ; Humans ; Mutation ; Species Specificity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    A receptor component of the chloroplast protein translocation machinery (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: The chloroplast outer envelope protein OEP86 functions as a receptor in precursor protein translocation into chloroplasts. Sequence analysis suggests that the precursor of OEP86 is directed to the chloroplast outer envelope by a cleavable, negatively charged, and unusually long amino-terminal peptide. This presequence is unlike other potential targeting signals and suggests the existence of another membrane insertion pathway. Insertion of precursor OEP86 required the hydrolysis of adenosine triphosphate and the existence of surface exposed chloroplast membrane components, and it was not competed by another precursor protein destined for the internal plastid compartments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hirsch, S -- Muckel, E -- Heemeyer, F -- von Heijne, G -- Soll, J -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1989-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Botanisches Institut, Universitat Kiel, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801125" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Amino Acid Sequence ; Chloroplast Proteins ; Chloroplasts/*metabolism ; *GTP-Binding Proteins ; Hydrogen-Ion Concentration ; Intracellular Membranes/metabolism ; Molecular Sequence Data ; Molecular Weight ; Peas ; Plant Proteins/chemistry/*metabolism ; Protein Precursors/chemistry/*metabolism ; Protein Processing, Post-Translational ; Ribulose-Bisphosphate Carboxylase/metabolism
    Print ISSN: 0036-8075
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  • 11
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    NSF Takes Leap Into School Reform (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1936-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836508" target="_blank"〉PubMed〈/a〉
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  • 12
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    Walker unveils r&d strategy (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1938.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836509" target="_blank"〉PubMed〈/a〉
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  • 13
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    Response (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, T P -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1932-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836506" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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  • 14
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    Offspring in the sea (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jablonski, D -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):2029-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836521" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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  • 15
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    Corrections and clarifications (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: Figure 1, parts A and C (p. 1349), of the Research Article "Calcium-calmodulin modula- tion of the olfactory cyclic nucleotide-gated cation channel" by Mingyao Liu et al. (25 Nov., p. 1348) were incorrectly printed. The correct figures appear below. On page 1351 of the same article, in line 25 of the first column of text, "GMP" should have been "AMP." In the second line of the text on page 1352, the first "(C.Ln)o" should have been "(C.Ln)c."〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 23;266(5193):1933.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836507" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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  • 16
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    This week in science (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 23;266(5193):1923.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836504" target="_blank"〉PubMed〈/a〉
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  • 17
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    Assembly of transcriptionally active RNA polymerase I initiation factor SL1 from recombinant subunits (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: Initiation of ribosomal RNA synthesis by RNA polymerase I requires the promoter selectivity factor SL1, which consists of the TATA-binding protein, TBP, and three associated factors, TAFIS 110, 63, and 48. Here the in vivo and in vitro assembly of functional SL1 complexes from recombinant TAFIS and TBP are reported. Complexes containing TBP and all three TAFIS were as active in supporting transcription from the human ribosomal RNA gene promoter as endogenous SL1, whereas partial complexes without TBP did not efficiently direct transcription in vitro. These results suggest that TAFIS 110, 63, and 48, together with TBP, are necessary and sufficient to reconstitute a transcriptionally active SL1 complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zomerdijk, J C -- Beckmann, H -- Comai, L -- Tjian, R -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):2015-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720-3204.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801130" target="_blank"〉PubMed〈/a〉
    Keywords: DNA-Binding Proteins/chemistry/*metabolism ; HeLa Cells ; Humans ; *Pol1 Transcription Initiation Complex Proteins ; Promoter Regions, Genetic ; RNA, Ribosomal/*genetics ; Recombinant Fusion Proteins/metabolism ; TATA Box ; *TATA-Binding Protein Associated Factors ; TATA-Box Binding Protein ; *Transcription Factor TFIID ; Transcription Factors/chemistry/*metabolism ; *Transcription, Genetic
    Print ISSN: 0036-8075
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  • 18
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    DNA repair works it works its way to the top (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, E -- Koshland, D E Jr -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1926-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801115" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Composition ; DNA Damage ; DNA Ligases/*metabolism ; DNA Polymerase I/metabolism ; *DNA Repair ; DNA Replication ; Humans ; Neoplasms/genetics ; Science ; Transcription, Genetic
    Print ISSN: 0036-8075
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  • 19
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    Mechanisms of DNA excision repair (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sancar, A -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1954-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801120" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Antineoplastic Agents/therapeutic use ; Cell Division ; DNA/metabolism ; DNA Adducts/metabolism ; DNA Damage ; *DNA Repair ; DNA Replication ; Endodeoxyribonucleases/metabolism ; Escherichia coli/metabolism ; *Escherichia coli Proteins ; Humans ; Models, Biological ; Neoplasms/drug therapy
    Print ISSN: 0036-8075
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  • 20
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    Trans-acting dosage effects on the expression of model gene systems in maize aneuploids (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: The reduction in vigor of aneuploids was classically thought to be due to the imbalance of gene products expressed from the varied chromosome relative to those from the remainder of the genome. In this study, the dosage of chromosomal segments was varied, but the transcript level of most genes encoded therein showed compensation for the number of copies of the gene. Genes whose dosage was not altered were affected by aneuploidy of unlinked chromosomal segments. The phenotypic effects of aneuploidy and of a substantial fraction of quantitative variation are hypothesized to be the consequence of an altered dosage-sensitive regulatory system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guo, M -- Birchler, J A -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1999-2002.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836517" target="_blank"〉PubMed〈/a〉
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  • 21
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    Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: HIV integrase is the enzyme responsible for inserting the viral DNA into the host chromosome; it is essential for HIV replication. The crystal structure of the catalytically active core domain (residues 50 to 212) of HIV-1 integrase was determined at 2.5 A resolution. The central feature of the structure is a five-stranded beta sheet flanked by helical regions. The overall topology reveals that this domain of integrase belongs to a superfamily of polynucleotidyl transferases that includes ribonuclease H and the Holliday junction resolvase RuvC. The active site region is identified by the position of two of the conserved carboxylate residues essential for catalysis, which are located at similar positions in ribonuclease H. In the crystal, two molecules form a dimer with a extensive solvent-inaccessible interface of 1300 A2 per monomer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dyda, F -- Hickman, A B -- Jenkins, T M -- Engelman, A -- Craigie, R -- Davies, D R -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1981-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD 20892-0560.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801124" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Binding Sites ; Crystallization ; Crystallography, X-Ray ; DNA Nucleotidyltransferases/*chemistry ; HIV-1/*enzymology ; Hydrogen Bonding ; Integrases ; Models, Molecular ; Molecular Sequence Data ; Protein Folding ; Protein Structure, Secondary ; Ribonuclease H/chemistry ; Solubility ; Virus Integration
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  • 22
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    Taking a Bottom-to-Sky "Slice" of the Arctic Ocean (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Travis, J -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1947-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836513" target="_blank"〉PubMed〈/a〉
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  • 23
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    High-tech partnership (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krige, J -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):2028-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836520" target="_blank"〉PubMed〈/a〉
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  • 24
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    Fatty acylation of two internal lysine residues required for the toxic activity of Escherichia coli hemolysin (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: Hemolysin of Escherichia coli is activated by fatty acylation of the protoxin, directed by the putative acyl transferase HlyC and by acyl carrier protein (ACP). Mass spectrometry and Edman degradation of proteolytic products from mature toxin activated in vitro with tritium-labeled acylACP revealed two fatty-acylated internal lysine residues, lysine 564 and lysine 690. Resistance of the acylation to chemical treatments suggested that fatty acid was amide linked. Substitution of the two lysines confirmed that they were the only sites of acylation and showed that although each was acylated in the absence of the other, both sites were required for in vivo toxin activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stanley, P -- Packman, L C -- Koronakis, V -- Hughes, C -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1992-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Cambridge University, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801126" target="_blank"〉PubMed〈/a〉
    Keywords: Acyl Carrier Protein/metabolism ; Acylation ; Acyltransferases/metabolism ; Amino Acid Sequence ; Animals ; Bacterial Proteins/chemistry/metabolism/*toxicity ; Bacterial Toxins/chemistry/metabolism/*toxicity ; *Escherichia coli ; *Escherichia coli Proteins ; Hemolysin Proteins/chemistry/metabolism/*toxicity ; Hemolysis ; Horses ; Lysine/metabolism ; Mass Spectrometry ; Molecular Sequence Data ; Protein Precursors/metabolism ; Sequence Alignment
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    Mismatch repair, genetic stability, and cancer (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Modrich, P -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1959-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Duke University Medical Center, Durham, NC 27710.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801122" target="_blank"〉PubMed〈/a〉
    Keywords: Base Composition ; Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics ; DNA Damage ; *DNA Repair ; DNA Replication ; Escherichia coli/genetics ; Genome, Bacterial ; Humans ; Mutation ; Neoplasms/*genetics ; Recombination, Genetic
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    Isotopic composition of old ground water from lake agassiz: implications for late pleistocene climate (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: A uniform oxygen isotope value of -25 per mil was obtained from old ground water at depths of 20 to 30 meters in a thick deposit of clay in the southern part of the glacial Lake Agassiz basin. The lake occupied parts of North Dakota and southern Manitoba at the end of the last glacial maximum and received water from the ice margin and the interior plains region of Canada. Ground water from thick late Pleistocene-age clay deposits elsewhere, a till in southern Saskatchewan, and a glaciolacustrine deposit in northern Ontario show the same value at similar depths. These sites are at about 50 degrees N latitude, span a distance of 2000 kilometers, and like the Lake Agassiz sites, have a ground-water velocity of less than a few millimeters per year. The value of -25 per mil is characteristic of meltwater impounded in the southern basin of Lake Agassiz. This value corresponds to an estimated air temperature of -16 degrees C, compared with the modern temperature of 0 degrees C for this area.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Remenda, V H -- Cherry, J A -- Edwards, T W -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1975-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836515" target="_blank"〉PubMed〈/a〉
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    Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: RNA polymerase I and II transcription factors SL1 and TFIID, respectively, are composed of the TATA-binding protein (TBP) and a set of TBP-associated factors (TAFs) responsible for promoter recognition. How the universal transcription factor TBP becomes committed to a TFIID or SL1 complex has not been known. Complementary DNAs encoding each of the three TAFIs that are integral components of SL1 have not been isolated. Analysis of subunit interactions indicated that the three TAFIs can bind individually and specifically to TBP. In addition, these TAFIs interact with each other to form a stable TBP-TAF complex. When TBP was bound first by either TAFI110, 63, or 48, subunits of TFIID such as TAFII250 and 150 did not bind TBP. Conversely, if TBP first formed a complex with TAFII250 or 150, the subunits of SL1 did not bind TBP. These results suggest that a mutually exclusive binding specificity for TBP intrinsic to SL1 and TFIID subunits directs the formation of promoter- and RNA polymerase-selective TBP-TAF complexes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Comai, L -- Zomerdijk, J C -- Beckmann, H -- Zhou, S -- Admon, A -- Tjian, R -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1966-72.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley 94720-3204.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801123" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; Binding, Competitive ; Cloning, Molecular ; DNA, Complementary/genetics ; DNA-Binding Proteins/chemistry/genetics/isolation & purification/*metabolism ; HeLa Cells ; Humans ; Molecular Sequence Data ; *Pol1 Transcription Initiation Complex Proteins ; Promoter Regions, Genetic ; Protein Binding ; RNA Polymerase I/metabolism ; TATA Box ; *TATA-Binding Protein Associated Factors ; TATA-Box Binding Protein ; Transcription Factor TFIID ; Transcription Factors/chemistry/genetics/isolation & purification/*metabolism ; Transcription, Genetic
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    Most nations miss the mark on emission-control plans (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1939.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836510" target="_blank"〉PubMed〈/a〉
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    Vignette: fond hopes (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 23;266(5193):2028.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836519" target="_blank"〉PubMed〈/a〉
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    Coordinate initiation of Drosophila development by regulated polyadenylation of maternal messenger RNAs (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-23
    Description: Pattern formation in Drosophila depends initially on the translational activation of maternal messenger RNAs (mRNAs) whose protein products determine cell fate. Three mRNAs that dictate anterior, dorsoventral, and terminal specification--bicoid, Toll, and torso, respectively--showed increases in polyadenylate [poly(A)] tail length concomitant with translation. In contrast, posteriorly localized nanos mRNA, although also translationally activated, was not regulated by poly(A) status. These results implicate at least two mechanisms of mRNA activation in flies. Studies with bicoid mRNA showed that cytoplasmic polyadenylation is necessary for translation, establishing this pathway as essential for embryogenesis. Combined, these experiments identify a regulatory pathway that can coordinate initiation of maternal pattern formation systems in Drosophila.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Salles, F J -- Lieberfarb, M E -- Wreden, C -- Gergen, J P -- Strickland, S -- GM51584/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1996-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, University Medical Center at Stony Brook, NY 11794-8651.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801127" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cytoplasm/metabolism ; Drosophila/*embryology/genetics ; *Drosophila Proteins ; Embryonic Development ; Female ; *Homeodomain Proteins ; Insect Hormones/genetics ; Membrane Glycoproteins/genetics ; Molecular Sequence Data ; Morphogenesis ; Ovary/metabolism ; Poly A/*metabolism ; *Protein Biosynthesis ; Protein-Tyrosine Kinases/genetics ; RNA, Messenger/genetics/*metabolism ; *RNA-Binding Proteins ; *Receptor Protein-Tyrosine Kinases ; *Receptors, Cell Surface ; Toll-Like Receptors ; *Trans-Activators
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    Sled-type motion on the nanometer scale: determination of dissipation and cohesive energies of c60 (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: The tribological properties of C(60) on the mesoscopic scale were investigated with a scanning force microscope, which allowed simultaneous measurements of normal and lateral forces under ultrahigh-vacuum conditions. Islands of C(60), deposited on NaCl(001), could be moved by the action of the probing tip in a controlled way. Different modes of motion, such as translation and rotation, were observed. An extremely small dissipation energy of about 0.25 millielectron volt per molecule and a cohesive energy of 1.5 electron volts were determined in these nanometer-scale experiments. The corresponding shear strength of 0.05 to 0.1 megapascal was smaller by one order of magnitude than typical values of boundary lubricants. For C(60) on graphite, disruption of the islands was observed and collective motion of the islands could not be achieved. These results could find use in the field of nanotechnology; for example, C(60) islands could be developed into a sled-type transport system on the nanometer scale.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Luthi, R -- Meyer, E -- Haefke, H -- Howald, L -- Gutmannsbauer, W -- Guntherodt, H J -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1979-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836516" target="_blank"〉PubMed〈/a〉
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    Splicing of the rolA transcript of Agrobacterium rhizogenes in Arabidopsis (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: The rolA gene encoded on the Ri plasmid A4 of Agrobacterium rhizogenes is one of the transferred (TL-DNA) genes involved in the pathogenesis of hairy-root disease in plants. The function of the 100-amino acid protein product of rolA is unknown, although its expression causes physiological and developmental alterations in transgenic plants. The rolA gene of A. rhizogenes contains an intron in its untranslated leader region that has features typical of plant pre-messenger RNA introns. Transcription and splicing of the rolA pre-messenger RNA occur in the plant cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Magrelli, A -- Langenkemper, K -- Dehio, C -- Schell, J -- Spena, A -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1986-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Plank-Institut fur Zuchtungsforschung, Cologne, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7528444" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/*genetics/microbiology ; Base Sequence ; Cloning, Molecular ; DNA, Bacterial/genetics ; Genes, Bacterial ; Introns ; Molecular Sequence Data ; Mutation ; Plants, Genetically Modified ; *Plasmids ; RNA Precursors/*genetics ; *RNA Splicing ; RNA, Bacterial/*genetics ; Rhizobium/*genetics ; Transcription, Genetic
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    Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5 (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: Upon entry into a host cell, retroviruses direct the reverse transcription of the viral RNA genome and the establishment of an integrated proviral DNA. The retroviral integrase protein (IN) is responsible for the insertion of the viral DNA into host chromosomal targets. The two-hybrid system was used to identify a human gene product that binds tightly to the human immunodeficiency virus-type 1 (HIV-1) integrase in vitro and stimulates its DNA-joining activity. The sequence of the gene suggests that the protein is a human homolog of yeast SNF5, a transcriptional activator required for high-level expression of many genes. The gene, termed INI1 (for integrase interactor 1), may encode a nuclear factor that promotes integration and targets incoming viral DNA to active genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kalpana, G V -- Marmon, S -- Wang, W -- Crabtree, G R -- Goff, S P -- U01 AI 24845/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):2002-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, NY 10032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801128" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; Chromosomal Proteins, Non-Histone ; DNA Nucleotidyltransferases/*metabolism ; DNA, Complementary/genetics ; DNA, Viral/metabolism ; DNA-Binding Proteins/chemistry/genetics/*metabolism ; HIV-1/*enzymology/genetics ; Humans ; Integrases ; Molecular Sequence Data ; Molecular Weight ; Oligodeoxyribonucleotides/metabolism ; Open Reading Frames ; Sequence Alignment ; Transcription Factors/chemistry/*metabolism ; Tumor Cells, Cultured ; Virus Integration ; Zinc Fingers
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    An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-23
    Description: A synthetic combinatorial library containing 52,128,400 D-amino acid hexapeptides was used to identify a ligand for the mu opioid receptor. The peptide, Ac-rfwink-NH2, bears no resemblance to any known opioid peptide. Simulations using molecular dynamics, however, showed that three amino acid moieties have the same spatial orientation as the corresponding pharmacophoric groups of the opioid peptide PLO17. Ac-rfwink-NH2 was shown to be a potent agonist at the mu receptor and induced long-lasting analgesia in mice. Analgesia produced by intraperitoneally administered Ac-rfwink-NH2 was blocked by intracerebroventricular administration of naloxone, demonstrating that this peptide may cross the blood-brain barrier.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dooley, C T -- Chung, N N -- Wilkes, B C -- Schiller, P W -- Bidlack, J M -- Pasternak, G W -- Houghten, R A -- DA-000138/DA/NIDA NIH HHS/ -- DA-02615/DA/NIDA NIH HHS/ -- DA-03742/DA/NIDA NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):2019-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Torrey Pines Institute for Molecular Studies, San Diego, CA 92121.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801131" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Analgesics/chemistry/metabolism/*pharmacology ; Animals ; Brain/metabolism ; Dose-Response Relationship, Drug ; Endorphins/pharmacology ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)- ; Enkephalin, D-Penicillamine (2,5)- ; Enkephalins/metabolism ; Guinea Pigs ; Injections, Intraventricular ; Male ; Mice ; Models, Molecular ; Molecular Sequence Data ; Naloxone/administration & dosage/pharmacology ; Opioid Peptides/chemistry/metabolism/*pharmacology ; Pain Measurement ; Protein Conformation ; Rats ; Receptors, Opioid, mu/agonists/metabolism ; Stereoisomerism
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    HIV integrase structure catalyzes drug search (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, C -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1946.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801119" target="_blank"〉PubMed〈/a〉
    Keywords: Antiviral Agents/pharmacology ; Binding Sites ; Crystallization ; Crystallography, X-Ray ; DNA Nucleotidyltransferases/antagonists & inhibitors/*chemistry/metabolism ; DNA-Binding Proteins/metabolism ; Drug Design ; HIV-1/drug effects/*enzymology ; Integrases ; Models, Molecular ; Virus Integration
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    Coral reef catastrophe (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ogden, J C -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1931.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836505" target="_blank"〉PubMed〈/a〉
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    Oncogenes reach a milestone (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1942-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801118" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Transformation, Neoplastic/*genetics ; *Genes, Tumor Suppressor ; Genes, ras ; Genes, src ; Humans ; Neoplasms/etiology/*genetics ; *Oncogenes ; Protein-Tyrosine Kinases/genetics/metabolism ; Proto-Oncogenes ; Translocation, Genetic
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    A unified polymerase mechanism for nonhomologous DNA and RNA polymerases (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steitz, T A -- Smerdon, S J -- Jager, J -- Joyce, C M -- GM28550/GM/NIGMS NIH HHS/ -- GM39546/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):2022-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7528445" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Binding Sites ; Crystallization ; Crystallography, X-Ray ; DNA Polymerase I/*chemistry/metabolism ; DNA-Directed RNA Polymerases/*chemistry/metabolism ; HIV Reverse Transcriptase ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Protein Folding ; RNA-Directed DNA Polymerase/*chemistry/metabolism ; Viral Proteins
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    Embryo cloners jumped the gun (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 23;266(5193):1949.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644654" target="_blank"〉PubMed〈/a〉
    Keywords: *Cloning, Organism ; Deception ; *Embryo Research ; Embryo, Mammalian ; Ethical Review ; Ethics ; Ethics Committees ; Ethics Committees, Research ; Federal Government ; Government ; Government Regulation ; Humans ; National Institutes of Health (U.S.) ; Organizational Policy ; *Research ; Research Personnel ; *Scientific Misconduct ; Social Control, Formal ; United States ; Universities
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    Rpoducts & materials (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 23;266(5193):2034.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836522" target="_blank"〉PubMed〈/a〉
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    Russian law targets genetic engineering (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 23;266(5193):1935.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644653" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Warfare ; *DNA, Recombinant ; *Ecology ; Genetic Research ; Genetics ; *Government Regulation ; Hazardous Substances ; Microbiology ; Plants, Genetically Modified ; Public Health ; Russia ; *Social Control, Formal
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    Astronomy and world politics (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gingerich, O -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):2027-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836518" target="_blank"〉PubMed〈/a〉
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    PCR products and CITES (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, M -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1930.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801116" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conservation of Natural Resources/*legislation & jurisprudence ; *Dna ; Government Agencies ; Licensure ; *Polymerase Chain Reaction ; United States
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    Official forecasts pushed out to a year ahead (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, R A -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1940-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836511" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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    FBI says sting nabs biotech spies (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Travis, J -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1941.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801117" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology/*legislation & jurisprudence ; *Cell Line ; Erythropoietin/*biosynthesis ; Government Agencies ; Humans ; Patents as Topic ; Recombinant Proteins/*biosynthesis ; Russia ; *Theft ; United States
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  • 46
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    Nanomaterials: a membrane-based synthetic approach (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: Materials with nanoscopic dimensions not only have potential technological applications in areas such as device technology and drug delivery but also are of fundamental interest in that the properties of a material can change in this regime of transition between the bulk and molecular scales. In this article, a relatively new method for preparing nanomaterials, membrane-based synthesis, is reviewed. This method entails synthesis of the desired material within the pores of a nanoporous membrane. Because the membranes used contain cylindrical pores of uniform diameter, monodisperse nanocylinders of the desired material, whose dimensions can be carefully controlled, are obtained. This "template" method has been used to prepare polymers, metals, semiconductors, and other materials on a nanoscopic scale.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, C R -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836514" target="_blank"〉PubMed〈/a〉
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  • 47
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    The production of 34S-depleted sulfide during bacterial disproportionation of elemental sulfur (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: Bacteria that disproportionate elemental sulfur fractionate sulfur isotopes such that sulfate is enriched in sulfur-34 by 12.6 to 15.3 per mil and sulfide is depleted in sulfur-34 by 7.3 to 8.6 per mil. Through a repeated cycle of sulfide oxidation to S0 and subsequent disproportionation, these bacteria can deplete sedimentary sulfides in sulfur-34. A prediction, borne out by observation, is that more extensive sulfide oxidation will lead to sulfides that are more depleted in sulfur-34. Thus, the oxidative part of the sulfur cycle creates circumstances by which sulfides become more depleted in sulfur-34 than would be possible with sulfate-reducing bacteria alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Canfield, D E -- Thamdrup, B -- New York, N.Y. -- Science. 1994 Dec 23;266:1973-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Marine Microbiology, Bremen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11540246" target="_blank"〉PubMed〈/a〉
    Keywords: Denmark ; Ferric Compounds ; Geologic Sediments/*microbiology ; Germany ; Oceans and Seas ; Oxidation-Reduction ; Sulfides/*metabolism ; Sulfur/*metabolism ; Sulfur Isotopes ; Sulfur-Reducing Bacteria/*metabolism ; Water Microbiology
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    Transcription-coupled repair and human disease (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hanawalt, P C -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):1957-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Standford University, CA 94305-5020.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7801121" target="_blank"〉PubMed〈/a〉
    Keywords: Cockayne Syndrome/*genetics ; DNA Damage ; DNA Glycosylases ; DNA Helicases/metabolism ; *DNA Repair ; DNA Replication ; Growth Disorders/genetics ; Hair Diseases/*genetics ; Humans ; Intellectual Disability/genetics ; N-Glycosyl Hydrolases/metabolism ; RNA Polymerase II/metabolism ; Transcription Factors/metabolism ; *Transcription Factors, General ; *Transcription, Genetic ; *Transcriptional Elongation Factors ; Xeroderma Pigmentosum/*genetics
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    Specific association of human telomerase activity with immortal cells and cancer (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-23
    Description: Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. A highly sensitive assay for measuring telomerase activity was developed. In cultured cells representing 18 different human tissues, 98 of 100 immortal and none of 22 mortal populations were positive for telomerase. Similarly, 90 of 101 biopsies representing 12 human tumor types and none of 50 normal somatic tissues were positive. Normal ovaries and testes were positive, but benign tumors such as fibroids were negative. Thus, telomerase appears to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, N W -- Piatyszek, M A -- Prowse, K R -- Harley, C B -- West, M D -- Ho, P L -- Coviello, G M -- Wright, W E -- Weinrich, S L -- Shay, J W -- AG07992/AG/NIA NIH HHS/ -- CA50195/CA/NCI NIH HHS/ -- CA65178/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1994 Dec 23;266(5193):2011-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Geron Corporation, Menlo Park, CA 94025.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7605428" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Cell Division ; Cell Line ; Cell Line, Transformed/enzymology ; DNA Nucleotidylexotransferase/*metabolism ; Enzyme Activation ; Enzyme Repression ; Female ; Humans ; Male ; Molecular Sequence Data ; Neoplasms/*enzymology ; Ovary/enzymology ; Polymerase Chain Reaction ; Testis/enzymology ; Tumor Cells, Cultured
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    Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: Calcium-calmodulin-dependent protein kinase II (CaMKII) is a necessary component of the cellular machinery underlying learning and memory. Here, a constitutively active form of this enzyme, CaMKII(1-290), was introduced into neurons of hippocampal slices with a recombinant vaccinia virus to test the hypothesis that increased postsynaptic activity of this enzyme is sufficient to produce long-term synaptic potentiation (LTP), a prominent cellular model of learning and memory. Postsynaptic expression of CaMKII(1-290) increased CaMKII activity, enhanced synaptic transmission, and prevented more potentiation by an LTP-inducing protocol. These results, together with previous studies, suggest that postsynaptic CaMKII activity is necessary and sufficient to generate LTP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pettit, D L -- Perlman, S -- Malinow, R -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1881-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neuroscience Program, University of Iowa, Iowa City 52242.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997883" target="_blank"〉PubMed〈/a〉
    Keywords: 2-Amino-5-phosphonovalerate/pharmacology ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 ; Calcium-Calmodulin-Dependent Protein Kinases/*metabolism ; Cell Line ; Genetic Vectors ; Hippocampus/cytology/enzymology/*physiology ; In Vitro Techniques ; Long-Term Potentiation/drug effects/*physiology ; Membrane Potentials ; Patch-Clamp Techniques ; Pyramidal Cells/enzymology/*physiology ; Rats ; Recombinant Proteins/metabolism ; Synaptic Transmission/drug effects/*physiology ; Transfection ; Vaccinia virus/genetics/physiology
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    Argentine dinos vie for heavyweight titles (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Appenzeller, T -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1805.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737065" target="_blank"〉PubMed〈/a〉
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    Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: Representational difference analysis was used to isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and Epstein-Barr virus. These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chang, Y -- Cesarman, E -- Pessin, M S -- Lee, F -- Culpepper, J -- Knowles, D M -- Moore, P S -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1865-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997879" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*complications ; Amino Acid Sequence ; Base Composition ; Base Sequence ; Blotting, Southern ; Cloning, Molecular ; DNA, Viral/*analysis/chemistry/genetics ; Female ; Herpesviridae/*genetics ; Herpesvirus 2, Saimiriine/genetics ; Herpesvirus 4, Human/genetics ; Humans ; Male ; Molecular Sequence Data ; Nucleic Acid Hybridization ; Open Reading Frames ; Polymerase Chain Reaction ; Retrospective Studies ; Sarcoma, Kaposi/etiology/*virology ; Sequence Homology, Amino Acid
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    The South pole region of the moon as seen by clementine (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: The Clementine mission has provided the first comprehensive set of high-resolution images of the south pole region of the moon. Within 5 degrees of latitude of the pole, an area of an estimated 30,000 square kilometers remained in shadow during a full lunar rotation and is a promising target for future exploration for ice deposits. The Schrodinger Basin (320 kilometers in diameter), centered at 75 degrees S, is one of the two youngest, least modified, great multiring impact basins on the moon. A large maar-type volcano localized along a graben within the Schrodinger Basin probably erupted between 1 and 2 billion years ago.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shoemaker, E M -- Robinson, M S -- Eliason, E M -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1851-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737080" target="_blank"〉PubMed〈/a〉
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    Maximum parasitism rates and successful biological control (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hawkins, B A -- Cornell, H V -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1886.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737084" target="_blank"〉PubMed〈/a〉
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    Clementine observations of the aristarchus region of the moon (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: Multispectral and topographic data acquired by the Clementine spacecraft provide information on the composition and geologic history of the Aristarchus region of the moon. Altimetry profiles show the Aristarchus plateau dipping about 1 degrees to the north-northwest and rising about 2 kilometers above the surrounding lavas of Oceanus Procellarum to the south. Dark, reddish pyroclastic glass covers the plateau to average depths of 10 to 30 meters, as determined from the estimated excavation depths of 100- to 1000-meter-diameter craters that have exposed materials below the pyroclastics. These craters and the walls of sinuous rilles also show that mare basalts underlie the pyroclastics across much of the plateau. Near-infrared images of Aristarchus crater reveal olivine-rich materials and two kilometer-sized outcrops of anorthosite in the central peaks. The anorthosite could be either a derivative of local magnesium-suite magmatism or a remnant of the ferroan anorthosite crust that formed over the primordial magma ocean.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McEwen, A S -- Robinson, M S -- Eliason, E M -- Lucey, P G -- Duxbury, T C -- Spudis, P D -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1858-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737082" target="_blank"〉PubMed〈/a〉
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    Scientific evidence in court (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koshland, D E Jr -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1787.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737056" target="_blank"〉PubMed〈/a〉
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    The space telescope spies on ancient galaxy menageries (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flam, F -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1806.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737066" target="_blank"〉PubMed〈/a〉
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    A sharper view of impact craters from clementine data (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: The ultraviolet-visible camera on the Clementine spacecraft obtained high-spatial resolution images of the moon in five spectral channels. Impact craters mapped with these multispectral images show a scale of lithologic diversity that varies with crater size and target stratigraphy. Prominent lithologic variations (feldspathic versus basaltic) occur within the south wall of Copernicus (93 kilometers in diameter) on the scale of 1 to 2 kilometers. Lithologic diversity at Tycho (85 kilometers in diameter) is less apparent at this scale, although the impact melt of these two large craters is remarkably similar in this spectral range. The lunar surface within and around the smaller crater Giordano Bruno (22 kilometers in diameter) is largely dominated by the mixing of freshly excavated material with surrounding older soils derived from a generally similar feldspathic lithology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pieters, C M -- Staid, M I -- Fischer, E M -- Tompkins, S -- He, G -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1844-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737078" target="_blank"〉PubMed〈/a〉
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    Can sound drive fusion in a bubble? (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pool, R -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1804.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737064" target="_blank"〉PubMed〈/a〉
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    Is a new virus the cause of KS? (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1803-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997874" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*complications ; DNA, Viral/*analysis ; Herpesviridae/*genetics/isolation & purification ; Homosexuality, Male ; Humans ; Male ; Sarcoma, Kaposi/etiology/*virology
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  • 61
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    Ancient multiring basins on the moon revealed by clementine laser altimetry (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: Analysis of laser altimetry data from Clementine has confirmed and extended our knowledge of nearly obliterated multiring basins on the moon. These basins were formed during the early bombardment phase of lunar history, have been filled to varying degrees by mare lavas and regional ejecta blankets, and have been degraded by the superposition of large impact craters. The Mendel-Rydberg Basin, a degraded three-ring feature over 600 kilometers in diameter on the lunar western limb, is about 6 kilometers deep from rim to floor, only slightly less deep than the nearby younger and much better preserved Orientale Basin (8 kilometers deep). The South Pole-Aitken Basin, the oldest discernible impact feature on the moon, is revealed as a basin 2500 kilometers in diameter with an average depth of more than 13 kilometers, rim crest to floor. This feature is the largest, deepest impact crater yet discovered in the solar system. Several additional depressions seen in the data may represent previously unmapped ancient impact basins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spudis, P D -- Gillis, J J -- Reisse, R A -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1848-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737079" target="_blank"〉PubMed〈/a〉
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    Seasonal precipitation timing and ice core records (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steig, E J -- Grootes, P M -- Stuiver, M -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1885-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737083" target="_blank"〉PubMed〈/a〉
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    Expressed sequence tags (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, M M -- Emanuel, B S -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1790-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997870" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Specimen Banks ; Chromosome Mapping ; Cloning, Molecular ; *DNA, Complementary ; *Databases, Factual ; Gene Expression ; *Genome, Human ; Humans ; Sequence Analysis, DNA
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    Specification of C/EBP function during Drosophila development by the bZIP basic region (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: The biologically relevant interactions of a transcription factor are those that are important for function in the organism. Here, a transgenic rescue assay was used to determine which molecular functions of Drosophila CCAAT/enhancer binding protein (C/EBP), a basic region-leucine zipper transcription factor, are required for it to fulfill its essential role during development. Chimeric proteins that contain the Drosophila C/EBP (DmC/EBP) basic region, a heterologous zipper, and a heterologous activation domain could functionally substitute for DmC/EBP. Mammalian C/EBPs were also functional in Drosophila. In contrast, 9 of 25 single amino acid substitutions in the basic region disrupted biological function. Thus, the conserved basic region specifies DmC/EBP activity in the organism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rorth, P -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1878-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997882" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Animals, Genetically Modified ; Base Sequence ; Basic-Leucine Zipper Transcription Factors ; CCAAT-Enhancer-Binding Proteins ; DNA/metabolism ; DNA-Binding Proteins/chemistry/genetics/*physiology ; Drosophila/genetics/*growth & development ; Female ; G-Box Binding Factors ; *Leucine Zippers ; Male ; Molecular Sequence Data ; Nuclear Proteins/chemistry/genetics/*physiology ; Recombinant Fusion Proteins ; Transcription Factors/chemistry/genetics/*physiology ; Transcriptional Activation
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    Scholars defend bell curve (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 16;266(5192):1811.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737074" target="_blank"〉PubMed〈/a〉
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    100% natural polyester? (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 16;266(5192):1811.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737072" target="_blank"〉PubMed〈/a〉
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    Vignette: interview with dirac (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 16;266(5192):1889.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737086" target="_blank"〉PubMed〈/a〉
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    Questions about French cancer fund (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 16;266(5192):1810.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737071" target="_blank"〉PubMed〈/a〉
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    Imaging Alzheimer's (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 16;266(5192):1810.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737069" target="_blank"〉PubMed〈/a〉
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    Topographic-compositional units on the moon and the early evolution of the lunar crust (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: The distribution of elevations on the moon determined by Clementine deviates strongly from a normal distribution, suggesting that several geologic processes have influenced the topography. The hypsograms for the near side and far side of the moon are distinctly different, and these differences correlate with differences in composition as determined by Apollo orbital geochemistry, Clementine global multispectral imaging, and ground-based spectroscopy. The hypsograms and compositional data indicate the presence of at least five compositional-altimetric units. The lack of fill of the South Pole-Aitken Basin by mare basalts suggests poor production efficiency of mare basalt in the mantle of this area of the moon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lucey, P G -- Spudis, P D -- Zuber, M -- Smith, D -- Malaret, E -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1855-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737081" target="_blank"〉PubMed〈/a〉
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    Even a robot cricket always gets her mate (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bains, S -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1809.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737068" target="_blank"〉PubMed〈/a〉
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    Piot named head of new UN unit (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1798.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997872" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome ; Belgium ; History, 20th Century ; Research ; United Nations/*organization & administration
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    Other books of interest (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Forman, P -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1891-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737088" target="_blank"〉PubMed〈/a〉
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    To Mars, but not together (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1799-800.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737062" target="_blank"〉PubMed〈/a〉
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    Crystalline polymorph construction: correction (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leiserowitz, L -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1791-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737057" target="_blank"〉PubMed〈/a〉
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    DNA bending by asymmetric phosphate neutralization (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: DNA is often bent when complexed with proteins. Understanding the forces responsible for DNA bending would be of fundamental value in exploring the interplay of these macromolecules. A series of experiments was devised to test the hypothesis that proteins with cationic surfaces can induce substantial DNA bending by neutralizing phosphates on one DNA face. Repulsions between phosphates in the remaining anionic helix are predicted to result in an unbalanced compression force acting to deform the DNA toward the protein. This hypothesis is supported by the results of electrophoretic experiments in which DNA spontaneously bends when one helical face is partially modified by incorporation of neutral phosphate analogs. Phasing with respect to a site of intrinsic DNA curvature (hexadeoxyadenylate tract) permits estimation of the electrostatic bend angle, and demonstrates that such modified DNAs are deformed toward the neutralized surface, as predicted. Similar model systems may be useful in exploring the extent to which phosphate neutralization can account for DNA bending by particular proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Strauss, J K -- Maher, L J 3rd -- GM47814/GM/NIGMS NIH HHS/ -- P30 CA36727-08/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1829-34.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198-6805.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997878" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Cations/chemistry ; DNA/*chemistry ; DNA-Binding Proteins/chemistry ; Electrochemistry ; Electrophoresis, Polyacrylamide Gel ; Models, Molecular ; Molecular Sequence Data ; *Nucleic Acid Conformation ; Nucleosomes/chemistry ; Oligodeoxyribonucleotides ; Organophosphorus Compounds/chemistry ; Phosphates/*chemistry ; Thermodynamics
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    Upsetting the balance of forces in DNA (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crothers, D M -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1819-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sterling Chemistry Laboratory, Yale University, New Haven, CT 06511.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997876" target="_blank"〉PubMed〈/a〉
    Keywords: DNA/*chemistry ; Electrochemistry ; *Nucleic Acid Conformation ; Nucleosomes/chemistry ; Organophosphorus Compounds/chemistry ; Phosphates/chemistry ; Thermodynamics
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    Italy keeps EMBL anxiously waiting (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Biggin, S -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1798.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997871" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/organization & administration ; Animals ; Biotechnology ; Italy ; Mice ; *Molecular Biology
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    Imanishi-kari to leave tufts (1994)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 16;266(5192):1811.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737075" target="_blank"〉PubMed〈/a〉
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    Vertebrate vibrations (1994)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 16;266(5192):1810.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737070" target="_blank"〉PubMed〈/a〉
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    Corrections and clarifications (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: In reference 12 (p. 996) of the Perspective "Neuroscience on the net" by P. T. Fox and J. L. Lancaster (11 Nov., p. 994), errors appeared in three of the Uniform Resource Locators (URL's) listed. For BrainMap, the URL should have read, "http://biad 38.uthscsa.edu/brainmap/brainmap94.html"; for ICBM/SPMap, "http://www.loni.ucla.edu"; and for Genesis, "http://www.bbb.caltech.edu/GENESIS."〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 16;266(5192):1793.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737058" target="_blank"〉PubMed〈/a〉
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    Funding of newly submitted NIH grant applications (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mandel, H G -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1789.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997868" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government ; National Institutes of Health (U.S.)/*economics ; Research Support as Topic/*economics ; United States
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    An alternative to SH2 domains for binding tyrosine-phosphorylated proteins (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that participate in signaling by growth factors and oncogenes. A protein domain was identified that bound specifically to the tyrosine-phosphorylated form of its target protein but differs from known SH2 sequences. Phosphotyrosine-binding (PTB) domains were found in two proteins: SHC, a protein implicated in signaling through Ras; and SCK, encoded by a previously uncharacterized gene. The PTB domain of SHC specifically bound to a tyrosine-phosphorylated 145-kilodalton protein. PTB domains are an alternative to SH2 domains for specifically recruiting tyrosine-phosphorylated proteins into signaling complexes and are likely to take part in signaling by many growth factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kavanaugh, W M -- Williams, L T -- K11 HL02714/HL/NHLBI NIH HHS/ -- R01 HL32898/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1862-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of California, San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7527937" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; *Adaptor Proteins, Signal Transducing ; *Adaptor Proteins, Vesicular Transport ; Amino Acid Sequence ; Animals ; Cell Line ; Humans ; Mice ; Molecular Sequence Data ; Phosphoproteins/*metabolism ; Phosphorylation ; Phosphotyrosine ; Platelet-Derived Growth Factor/pharmacology ; Protein Binding ; Protein-Tyrosine Kinases/chemistry/metabolism ; Proteins/chemistry/*metabolism ; Shc Signaling Adaptor Proteins ; *Signal Transduction ; Tyrosine/*analogs & derivatives/metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The company that genome researchers love to hate (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1800-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997873" target="_blank"〉PubMed〈/a〉
    Keywords: *Biotechnology ; Chromosome Mapping ; DNA Repair ; DNA, Complementary/*genetics ; *Databases, Factual ; Gene Expression ; *Genome, Human ; Human Genome Project ; Humans ; National Institutes of Health (U.S.) ; Private Sector ; Public Sector ; Sequence Analysis, DNA ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 85
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    The clementine mission to the moon: scientific overview (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: In the course of 71 days in lunar orbit, from 19 February to 3 May 1994, the Clementine spacecraft acquired just under two million digital images of the moon at visible and infrared wavelengths. These data are enabling the global mapping of the rock types of the lunar crust and the first detailed investigation of the geology of the lunar polar regions and the lunar far side. In addition, laser-ranging measurements provided the first view of the global topographic figure of the moon. The topography of many ancient impact basins has been measured, and a global map of the thickness of the lunar crust has been derived from the topography and gravity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nozette, S -- Rustan, P -- Pleasance, L P -- Kordas, J F -- Lewis, I T -- Park, H S -- Priest, R E -- Horan, D M -- Regeon, P -- Lichtenberg, C L -- Shoemaker, E M -- Eliason, E M -- McEwen, A S -- Robinson, M S -- Spudis, P D -- Acton, C H -- Buratti, B J -- Duxbury, T C -- Baker, D N -- Jakosky, B M -- Blamont, J E -- Corson, M P -- Resnick, J H -- Rollins, C J -- Davies, M E -- Lucey, P G -- Malaret, E -- Massie, M A -- Pieters, C M -- Reisse, R A -- Simpson, R A -- Smith, D E -- Sorenson, T C -- Breugge, R W -- Zuber, M T -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1835-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737076" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 86
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    Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1 (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: The three-dimensional structure of a Staphylococcus aureus superantigen, toxic shock syndrome toxin-1 (TSST-1), complexed with a human class II major histocompatibility molecule (DR1), was determined by x-ray crystallography. The TSST-1 binding site on DR1 overlaps that of the superantigen S. aureus enterotoxin B (SEB), but the two binding modes differ. Whereas SEB binds primarily off one edge of the peptide binding site of DR1, TSST-1 extends over almost one-half of the binding site and contacts both the flanking alpha helices of the histocompatibility antigen and the bound peptide. This difference suggests that the T cell receptor (TCR) would bind to TSST-1:DR1 very differently than to DR1:peptide or SEB:DR1. It also suggests that TSST-1 binding may be dependent on the peptide, though less so than TCR binding, providing a possible explanation for the inability of TSST-1 to competitively block SEB binding to all DR1 molecules on cells (even though the binding sites of TSST-1 and SEB on DR1 overlap almost completely) and suggesting the possibility that T cell activation by superantigen could be directed by peptide antigen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, J -- Urban, R G -- Strominger, J L -- Wiley, D C -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1870-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Children's Hospital, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997880" target="_blank"〉PubMed〈/a〉
    Keywords: *Bacterial Toxins ; Binding Sites ; Crystallography, X-Ray ; Enterotoxins/*chemistry/metabolism ; HLA-DR1 Antigen/*chemistry/metabolism ; Humans ; Hydrogen Bonding ; Models, Molecular ; Protein Conformation ; Protein Structure, Secondary ; Receptors, Antigen, T-Cell/metabolism ; *Staphylococcus aureus ; Superantigens/*chemistry/metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 87
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    Cell cycle control and cancer (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: Multiple genetic changes occur during the evolution of normal cells into cancer cells. This evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair, and segregate the genome. Recent advances in our understanding of the cell cycle reveal how fidelity is normally achieved by the coordinated activity of cyclin-dependent kinases, checkpoint controls, and repair pathways and how this fidelity can be abrogated by specific genetic changes. These insights suggest molecular mechanisms for cellular transformation and may help to identify potential targets for improved cancer therapies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hartwell, L H -- Kastan, M B -- CA 61949/CA/NCI NIH HHS/ -- ES 05777/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1821-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, University of Washington, Seattle 98195.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997877" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Cell Aging ; *Cell Cycle ; *Cell Transformation, Neoplastic/genetics ; Cyclins/genetics/metabolism ; DNA Damage ; Humans ; Neoplasms/*etiology/pathology/prevention & control/therapy ; Signal Transduction ; Tumor Suppressor Protein p53/genetics/physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 88
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    Thrashing Out a Compromise on the LHC (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clery, D -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1799.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737063" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 89
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    Experimentalist's Career (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kremer, R L -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1890-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737087" target="_blank"〉PubMed〈/a〉
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  • 90
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    Malaria vaccine research (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: In our report "Activation of Raf as a result of recruitment to the plasma membrane" (3 June, p. 1463) (1), panels E and F of figure 1 on page 1464 were incorrect. The correct photographs appear below. In addition, the [See figure in the PDF file] second sentence of the legend to figure 1 should have read, "The Raf constructs were tagged at the COOH-terminus with a Glu-Glu epitope (MEYMPME) (24) for c-Raf, or at the NH(2)-terminus with both the Glu-Glu and the Myc (MEQKLISEEDL) (23) epitopes for RafCAAX"; the next-to-the-last sentence of the legend to figure 1 should have read, "The c-Raf constructs in (A through D) are Glu-Glu-tagged and were detected by using an anti Glu-Glu antibody, and the RafCAAX and Raf6QCAAX constructs used in E and F were detected by using the antibody to Raf COOH-terminal peptide"; and the third sentence of note 26 should have read, "After blocking with 5% milk in phosphate-buffered saline (M-PBS), cells were incubated with a mouse monoclonal antibody to Glu-Glu or a rabbit polyclonal antibody to a 20-amino acid COOH-terminal peptide of Raf-1 (Santa Cruz Biotechnology, Santa Cruz, California), washed, and incubated with donkey antibodies to mouse or rabbit IgG combined with Texas Red (Jackson) in M-PBS, washed, and mounted in FITC-Guard (Testog)."〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ballou, W R -- Diggs, C L -- Landry, S -- Hall, B F -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1792.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7864993" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; Humans ; International Cooperation ; *Malaria Vaccines ; National Institutes of Health (U.S.) ; *Research ; United States ; World Health Organization
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  • 91
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    A need to reinvent biotechnology regulation at the EPA (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, H I -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1815-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for International Studies, Stanford University, CA 94305-6010.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997875" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology/*legislation & jurisprudence ; *Containment of Biohazards ; *DNA, Recombinant ; Genetic Engineering/*legislation & jurisprudence ; Pest Control, Biological/legislation & jurisprudence ; Plants/genetics ; Risk Assessment ; United States ; *United States Environmental Protection Agency
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  • 92
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    New GOP Chairs Size Up Science (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1796-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737060" target="_blank"〉PubMed〈/a〉
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  • 93
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    Two senators target defense research (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- Mervis, J -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1797.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737061" target="_blank"〉PubMed〈/a〉
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  • 94
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    Other books of interest (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Livingston, K -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737089" target="_blank"〉PubMed〈/a〉
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  • 95
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    Products & materials (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 16;266(5192):1893.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737090" target="_blank"〉PubMed〈/a〉
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  • 96
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    The shape and internal structure of the moon from the clementine mission (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: Global topographic and gravitational field models derived from data collected by the Clementine spacecraft reveal a new picture of the shape and internal structure of the moon. The moon exhibits a 16-kilometer range of elevation, with the greatest topographic excursions occurring on the far side. Lunar highlands are in a state of near-isostatic compensation, whereas impact basins display a wide range of compensation states that do not correlate simply with basin size or age. A global crustal thickness map reveals crustal thinning under all resolvable lunar basins. The results indicate that the structure and thermal history of the moon are more complex than was previously believed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zuber, M T -- Smith, D E -- Lemoine, F G -- Neumann, G A -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1839-43.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737077" target="_blank"〉PubMed〈/a〉
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  • 97
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    Creme de la Creme (cont'd) (1994)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 16;266(5192):1811.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737073" target="_blank"〉PubMed〈/a〉
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  • 98
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    This week in science (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 16;266(5192):1785.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737055" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    EMBL and European cooperation in the life sciences (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kafatos, F C -- New York, N.Y. -- Science. 1994 Dec 16;266(5192):1789-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7997869" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; Europe ; Information Systems ; International Cooperation ; Italy ; *Molecular Biology
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  • 100
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    Sciencescope (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1994 Dec 16;266(5192):1795.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737059" target="_blank"〉PubMed〈/a〉
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