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  • Animals  (4,976)
  • Analytical Chemistry and Spectroscopy
  • Deutschland
  • Fisheries
  • 2005-2009  (5,037)
Collection
Keywords
Publisher
Years
Year
  • 1
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    La pêche maritime sénégalaise (2007)
    Details
    Publication Date: 2021-01-30
    Description: Ministère de l'économie et des Finances
    Description: Published
    Description: Pêche artisanale, pêche industrielle,pêche maritime,pêche sardinière, produits halieutiques,Transformation,
    Keywords: Fisheries ; Fishery products ; Marine fish ; Fisheries ; Artisanal fishing ; Fishery products
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 2
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    Manuel de Cogestion des pecheries : théories et études de cas au Japon, auxPhilippines et au Sénégal (2007)
    Details
    Publication Date: 2021-01-30
    Description: pêcherie; gestion des ressources; cymbium; poulpe; crevette
    Keywords: Fisheries ; Fishery management ; Biodiversity ; Fishery resources ; Biodiversity ; Fisheries ; Fishery management ; Fishery resources ; Bait fishing
    Repository Name: AquaDocs
    Type: Working Paper
    Format: 2371081 bytes
    Format: application/pdf
    Format: 27
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  • 3
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    Stratégies de communication globale du programme Girmac (2008)
    Programme Gestion Intégrée des Ressources Marines et Côtières, Dakar (Senegal)
    Details
    Publication Date: 2021-05-19
    Description: Fondée sur l'intégration des principes et démarqhes des sciences de l'information et de la communication avec ceux du marketing social et relationnel, la stratégie de communicaton du Programme Girmac se décline sous la forme d'une vision globale, des objectifs généraux, des cibles ainsi que des activités et outils spécifiques de communication
    Description: Published
    Description: Girmac. strategie de communication
    Keywords: Marine environment ; Communication ; Fisheries ; Communication ; Information scientists ; Communication systems ; Marine environment ; Fisheries ; Canoe fisheries
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 4
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    Estado de explotación del recurso besugo (Epigonus crassicaudus) en Chile (2007)
    Pontificia Universidad Católica de Valparaíso
    Details
    Publication Date: 2021-05-19
    Description: The exploitation status of cardinalfish (Epigonus crassicaudus) yielded in Chile between 33° to 41°S was analyzed. An indirect assessment was performed between 1997 and 2003 through size-structured model with a transition matrix defining the changes among sizes. The model was calibrated using size structures, official landings, catch-per-unit of effort (CPUE) taken from commercial fishing logbooks and standardized by generalized linear models (GLM). After 7 years of an intense fishery activity, we concluded that the cardinalfish resource in Chile is on the recruitment overfishing limit. On 2003, the spawning biomass with respect to the virginal spawning biomass is close to 40%. The biological references points (BRP) based on spawning per recruit biomass (SPR) support this assesment because the fishing mortality level on 2003 (Fact) was very close to fishing mortality level of 40% of SRP at virginal value (F40%).
    Description: Published
    Description: Besugo, Cardinalfish
    Keywords: Fisheries ; Stock assessment ; Exploitation ; Fisheries ; Stock assessment
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 5
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    The impact generated on Sea Turtles by Fisheries in the Southwestern Atlantic Ocean (2009)
    WWF Programa Marino para Latinoamérica y el Caribe
    Details
    Publication Date: 2021-05-19
    Description: This document, which is directed at the fishing sector, researchers, conservationists and fishery administrators, was developed by researchers who are members of the Specialists Group for Marine Turtle Research and conservation in the Southwestern Atlantic Ocean (SWA) in response to the urgent need to evaluate the impact generated on sea turtles by fisheries. Historically, sea turtle conservation efforts have focused almost exclusively on the protection of nesting beaches. Nevertheless, over the last decade, research has proved incidental mortality as a result of fishing activities to be one of the greatest threats to these animals. This type of interaction is not only problematic for turtles, but also generates financial losses for fishermen and businesses. In spite of the efforts that are currently underway, researchers still do not have a detailed understanding of the impact that bycatch produces on sea turtle populations in the SWA. We have a long way to go before its effects can be minimized. Further research is needed regarding the biology and ecology of the various turtle species as well as the effective application of mitigation measures. The life cycles of sea turtles are long and complex. Turtles occupy various ecosystems (nesting beaches, coastal, neritic and oceanic zones, as well as pelagic and demersal areas) throughout their lifetimes, transcending various Exclusive Economic Zones and International Waters. The five species that inhabit the SWA region perform vast feeding and reproductive migrations, traveling through areas where many different fishing fleets operate. Therefore, sea turtles in the SWA interact with virtually all fisheries. These circumstances make it necessary to carry out biological, fishing related and conservation studies on a regional level. The efficiency of the existing international and national legal instruments has yet to be determined, in terms of their effectiveness in protecting sea turtles. In some cases, legislation that is specifically related to the interaction between fisheries and turtles does exist, such as those laws requiring the mandatory use of turtle excluding devices (TEDs). There are also explicit bans on sea turtle capture. Nevertheless, none of these regulations prevent sea turtle bycatch. Although some regional legal instruments are needed, these and the existing legislation will only be effective if they are accompanied by a broader range of permanent education and control measures, to achieve the commitment of all the parties involved. The ecosystem approach is gaining popularity among fishery administration organizations. Research and conservation efforts should also be moving in that direction. A regional and international effort is required in order to compile information regarding the bycatch produced by the various types of fisheries and fleets operating in the area. The enormous increase in fishing pressure that these fleets are exerting in this area has not been accompanied by an increase in information regarding the bycatch of species that have no commercial value. Pelagic longlining is one of the fishing methods, which must be most closely monitored, due to the high levels of bycatch that it produces, as well its ample distribution throughout the region, and the high level of fishing effort that it accounts for. Coastal trawlers and gillnetters must also be considered critical players, because they too produce a large rate of bycatch. These are the three types of fisheries that are most broadly distributed throughout the region, accounting for the majority of the fishing effort. Most of the institutions that work toward sea turtle conservation in the area have only begun to address the issue of bycatch over the last decade. This timeframe is reflected in the scope and quantity of the available publications, as well as the progress of activities directed at mitigating this problem. All of the institutions that have been mentioned in this report have made the gathering of information regarding interaction between sea turtles and fisheries one of their top priorities. Some institutions are even developing working programs for monitoring fisheries and testing mitigation measures. Many of these institutions have managed to develop adequate relationships with fishermen, ship owners and administrators. Nevertheless, limited access to funding is an obstacle to the development and testing of mitigation measures. The SWA network, which is a very valuable instrument that was created in 2003, has allowed the region’s institutions and researchers to exchange information and share their experience, in addition to lending each other support in carrying out joint activities, thus strengthening sea turtle conservation efforts. The capacity demonstrated so far by the region’s researchers and institutions, testifies to their ability to continue to make progress in knowledge generation and tests of bycatch mitigation measures.
    Description: Published
    Keywords: Fisheries ; Ecology ; Fishing gear ; Fisheries ; Ecology ; Fishing gear
    Repository Name: AquaDocs
    Type: Book
    Format: 71 pp
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  • 6
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    Boletín Estadístico Pesquero 2008 (2009)
    MGAP | DINARA
    Details
    Publication Date: 2021-01-30
    Description: A partir de la firma del Proyecto de Gestión Pesquera DINARA-FAO (UTF/URU/025/URU), en septiembre de 2007, se comenzó a conformar una Unidad de Economía Pesquera. Sus objetivos se focalizaron en fortalecer la capacidad de recolección y análisis estadístico de la información socio-económica del sector. En el 2008 esta Unidad compiló y realizó un análisis de la información comprendida entre los años 2002 y 2007, reanudando luego de varios años esta publicación histórica. La misma fue un éxito en todo sentido, especialmente para consulta de los diferentes actores del sector. La aceptación y receptividad que ha tenido dicha publicación nos motiva y obliga a continuar en esta línea, rumbo a la obtención de un producto de valor y utilidad, basado exclusivamente en información oficial nacional. Este año retomamos la serie anual poniendo nuevamente a disposición de todos información actualizada, completa y de calidad que estamos seguros será nuevamente de gran beneficio para el sector público como privado, así como de interés para el público en general.
    Description: Published
    Keywords: Fisheries ; Trade ; Fishery statistics ; Fisheries ; Trade
    Repository Name: AquaDocs
    Type: Book
    Format: 48
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  • 7
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    Seychelles fisheries country profile : 1990-1994. (2006)
    Victoria: Seychelles Fishing Authority
    Details
    Publication Date: 2021-05-19
    Description: Seychelles is composed of over 100 islands with a land area of approximately 455 km², centred close to 4°30'S and 55°30'E. The combined coastline is approximately 600 km long, the oceanic shelf totals about 50 000 km² and the Exclusive Economic Zone (EEZ) is over 1 370 000 km². The total population (1994 census) stands at just under 74 000. in 1994, the population registered a growth rate of 2.2%. The GDP (1994) was SR 2373.8 million, fisheries representing 4.8% of this sum. Licensing agreements for foreign fishing activities provided a yearly revenue of SR8 million. Port Victoria is seen as a prime centre for tuna fishing operations in the Indian Ocean. In the artisanal fishery just under 900 persons are working. The largest contributor to catch by vessel type are the traditional whaler vessels representing 47.8% of the total catch. Over 66.3% of the catch is by the handline method. Carangidae representing 24% and Lutjanidae 19% of total landings. There are six specific objectives to the fisheries sector policy, which aims as resource development and maximisation of potential benefits. Nearshore fishery resources are considered to be heavily exploited, however opportunities exist around the distant islands and in deeper waters off the Mahe plateau shelf. Aquaculture of molluscs and prawns is being developed and carried out. The main constraints to development are seen as the lack of skilled manpower and foreign exchange.
    Description: Published
    Keywords: Country profile ; Fisheries ; Seychelles ; Statistics ; Fisheries ; Fishery statistics
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
    Format: 186058 bytes
    Format: 520444 bytes
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    Format: 19
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  • 8
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    Fisheries Science Collaborations: The Critical Role of the Community (2005)
    Details
    Publication Date: 2021-05-19
    Description: The present paper is based on a collation of information, through both a literature review and an internet search, on North American programs that involve some kind of scientific collaboration between fishers and fisheries scientists. It identifies four basic models of such collaboration and offers examples of collaborative activities that seem to fit into each of them. The first model defers to the expertise of the scientist for all major decisions and creates a strong programmatic distinction between what is science, and shall be done by scientists, and what are other, related activities that can be carried out by others. Various kinds of tagging programs, fisher advisory boards, at-sea research collaboration and many other activities fit this model. The second model, traditional ecological knowledge, recognizes that fishers have available to them a unique, local knowledge of the resource that can make a supplementary contribution to fisheries science. Several government, community and environmental groups are engaged in finding, recording and using this knowledge....
    Description: Unpublished
    Keywords: Mariculture ; Fisheries
    Repository Name: AquaDocs
    Type: Conference Material , Non-Refereed , Paper
    Format: 51395 bytes
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  • 9
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    Plan de acción nacional para la conservación de condrictios en las pesquerías uruguayas. (PAN - Condrictios Uruguay) (2008)
    DINARA
    Details
    Publication Date: 2021-05-19
    Description: Durante las últimas décadas se ha observado un incremento de la captura (descartada y retenida) de condrictios en las pesquerías artesanales e industriales, conjuntamente con un rápido crecimiento de las pesquerías no reguladas, lo cual ha ocasionado una disminución en muchas poblaciones de este grupo de peces en todos los mares del mundo. La sobrepesca y los elevados niveles de mortalidad ocasionados por la captura incidental, asi como la degradación y contaminación de áreas costeras donde se ubican las zonas de alimentación, reproducción y cría para muchas especies de condrictios, han colocado a este grupo de peces en una situación difícil. Estos hechos, combinados con el bajo potencial reproductivo y la estrategia de vida de la mayoría de las especies de condríctios, no permiten una recuperación de las poblaciones, cuando las mismas se ven enfrentadas a períodos de sobreexplotación. En las aguas de Uruguay ocurren aproximadamente 100 especies de condrictios, muchas de las cuales son capturadas por diferentes pesquerias, tanto de forma incidental como dirigida. Debido a la preocupación a nivel internacional sobre la sustentabilidad de las pesquerías de tiburones, la FAO en 1998 realizó una consulta internacional a expertos y desarrolló un “Plan de Acción Internacional para la Conservación y el Manejo de los Tiburones” (PAI - Tiburones), el cual fue adoptado en 1999. El objetivo del PAI - Tiburones es asegurar la conservación, el manejo y el uso sustentable a largo plazo de los tiburones. Al hacer referencia a “tiburones”, se incluyen a todos los condrictios (tiburones, batoideos y quimeras). Este documento se divide en dos Capítulos y cuatro Anexos. El primer capítulo incluye los objetivos del PAN - Condrictios Uruguay y las medidas propuestas para alcanzar los mismos. El segundo capítulo contiene un diagnóstico general de los condrictios, las pesquerías y el marco jurídico. Como anexos se incluyen una lista de especies de condrictios citadas para Uruguay junto a su status en las listas rojas de la UICN, una reseña biológica de las especies consideradas prioritaras, una lista de abreviaturas, y listas de instituciones y personas que participaron de las reuniones desarrolladas durante el proceso de elaboración del PAN – Condrictios Uruguay. Las medidas propuestas por el PAN - Condrictios Uruguay se deberán aplicar a todas las pesquerías efectuadas por buques de bandera uruguaya, incluso los que operan fuera de la zona económica exclusiva de Uruguay.
    Description: Published
    Description: chondrichthyan, legal norm
    Keywords: M42 ; Fisheries ; Fisheries ; Conservation
    Repository Name: AquaDocs
    Type: Book
    Format: 87
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  • 10
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    Plan de acción nacional para reducir la captura incidental de aves marinas en las pesquerías uruguayas (2008)
    DINARA
    Details
    Publication Date: 2021-05-19
    Description: La captura incidental en pesquerías comerciales ha sido identificada como una de las principales amenazas para la conservación de este grupo de aves, siendo los albatros (familia: Diomedeidae) y los petreles (familia: Procellariidae) las especies más afectadas. Debido a que los albatros y petreles presentan una gran longevidad y una baja fecundidad, pocas crías y un lento desarrollo, sus poblaciones son muy sensibles al aumento en la tasa de mortalidad causado por la captura incidental en las pesquerías. Anualmente son capturadas y muertas miles de aves marinas en las pesquerías comerciales que operan con diferentes configuraciones de palangre alrededor del mundo. Este arte, entre otras causas, está contribuyendo al descenso de varias poblaciones de albatros y preteles, configurando un claro riesgo de extinción de estas especies, si se permite que las tendencias actuales persistan. Las pesquerías de arrastre también interactúan con las aves marinas provocando la mortalidad de las mismas en un importante número. Otras pesquerías que capturan aves marinas son las que operan con redes de enmalle, redes de cerco y poteras. Respondiendo a la necesidad de reducir la mortalidad de aves marinas la Organización de las Naciones Unidas para la Agricultura y la Alimentación (FAO) desarrolló un Plan de Acción Internacional para Reducir la Captura Incidental de Aves Marinas en las Pesquerías de Palangre, el cual propicia la elaboración de Planes de Acción Nacionales en cada uno de sus países miembros. El objetivo del Plan de Acción Nacional – Aves Marinas de Uruguay es presentar un marco general que permita instrumentar medidas para la reducción de la captura incidental de aves marinas en todas las pesquerías de Uruguay.
    Description: Published
    Description: seabirds
    Keywords: M42 ; Fisheries ; Catching methods ; Fisheries
    Repository Name: AquaDocs
    Type: Book
    Format: 75
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  • 11
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    El impacto generado por las pesquerías en las tortugas marinas en el Océano Atlántico Sud Occidental (2009)
    WWF Programa Marino para Latinoamérica y el Caribe
    Details
    Publication Date: 2021-05-19
    Description: Este documento, dirigido al sector pesquero, investigadores, conservacionistas y administradores de las pesquerías, surge como respuesta de investigadores pertenecientes al Grupo de Especialistas en Investigación y Conservación de Tortugas Marinas en el Atlántico Sud Occidental (ASO) a la urgente necesidad de evaluar el impacto de las pesquerías sobre las tortugas marinas. Históricamente, los esfuerzos referidos a la conservación de las tortugas marinas se han dirigido casi exclusivamente a proteger las playas de anidación. Sin embargo en la última década se ha podido comprobar que una de las mayores amenazas es la mortalidad incidental causada por las pesquerías. Esta interacción no implica únicamente un problema para las tortugas, sino que también genera pérdidas económicas para los pescadores y las empresas.
    Description: This document, which is directed at the fishing sector, researchers, conservationists and fishery administrators, was developed by researchers who are members of the Specialists Group for Marine Turtle Research and Conservation in the Southwestern Atlantic Ocean (SWA) in response to the urgent need to evaluate the impact generated on sea turtles by fisheries. Historically, sea turtle conservation efforts have focused almost exclusively on the protection of nesting beaches. Nevertheless, over the last decade, research has proved incidental mortality as a result of fishing activities to be one of the greatest threats to these animals. This type of interaction is not only problematic for turtles, but also generates financial losses for fishermen and businesses.
    Description: Cont. fotografías
    Description: Published
    Description: Sea Turtle, keeping
    Keywords: Fisheries ; Ecology ; Fishing gear ; Fisheries ; Ecology ; Fishing gear
    Repository Name: AquaDocs
    Type: Book
    Format: 71
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  • 12
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    Report of the meeting: Third Meeting of the Preparatory Committee For the Preparation of the Partnership Conference: Mauritius, 01 November 1999 (2005)
    ACOPS
    Details
    Publication Date: 2021-01-30
    Description: Dr Sebek introduced the ACOPS report which sums up the activities undertaken since the last Preparatory Committee meeting all of which are detailed in Annex V. In particular, Dr Sebek said that several strategic partnerships were being forged in order that certain components of the work programme, as agreed at the First Preparatory Committee Meeting in Nairobi in February, could start as soon as possible. A good example of such a policy, in the field of root cause analyses was the anticipated co-operation with UNESCO.
    Description: Published
    Keywords: Fisheries
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
    Format: 1236599 bytes
    Format: 638617 bytes
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  • 13
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    Interaction of Marine Turtles with Fisheries in the Mediterranean (2005)
    UNEP; Regional Activity Centre for Specially Protected Areas (RAC/SPA)
    Details
    Publication Date: 2021-05-19
    Description: At present, the impact of accidental catch on sea turtle populations is one of the most urgent problems that must be solved to ensure the survival of all these species worldwide. In the Mediterranean, too, all marine turtle species are affected by fishing activities, in particular the loggerhead (Caretta caretta) and the green (Chelonia mydas) turtles, which are more common than the others and are the only ones breeding in this sea. Since the Mediterranean populations of both species seem to be genetically isolated from the Atlantic ones (Bowen et al., 1992; Bowen et al., 1993; Laurent et al., 1993), fishing-induced mortality probably cannot be counterbalanced by immigration. This implies that the survival of the Mediterranean populations of these species depends to a great extent on the conservation effort that the Mediterranean countries carry on in the near future to reduce accidental mortality.
    Description: Unpublished
    Keywords: Marine turtles ; Fisheries
    Repository Name: AquaDocs
    Type: Working Paper , Non-Refereed
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  • 14
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    Un estudio de histamina en Dorado MAHI-MAHI Coryphaena hippurus y su relación con la calidad de producto de la pesca ecuatoriana (2009)
    INP (Ecuador)
    Details
    Publication Date: 2021-05-19
    Description: El presente trabajo llama la atención a las recientes epidemias de intoxicación histamínicas reportadas en los Estados Unidos, debido al consumo del dorado (Coryphaena hippurus) o Mahi-Mah, contaminado. Esto dió como resultado la prohición de las importaciones de esta especie, proveniente de varios países entre ellos el Ecuador, y siendo el dorado una especie de relativa importancia económica en este país, dicha prohibición ha preocupado al sector pesquero. Los estudios llevados a cabo muestran claramente la susceptibilidad de esta especie a desarrollar histamina. Esto se debe principalmente a la temperatura a la que está expuesta, pues la demora antes de enhielar el pescado es la etapa crítica. Los resultados muestran un aumento exponencial de los niveles de histamina, en ciertos casos después de tan solo 9 horas de almacenaje a temperaturas ambientales entre 25-30°C. Los niveles de histamina en pescado muestreado en el mercado local fueron tan altos como 250 mg/100g de muestra. Se demuestra que el problema se debe fundamentalmente al mal manejo de la captura por parte de la flota artesanal, y la subsecuente falta de infraestructura adecuada para conservarla, es decir, no se enfría el pescado. Sin embargo, el estudio muestra que una reducción de la temperatura del pescado de solo 15° menos, podría dar como resultado un producto de mayor calidad. En el presente trabajo se hacen recomendaciones para establecer un nivel máximo permitido para la exportación de 10 mg%, y se comparan dos métodos rápidos de análisis.
    Description: Published
    Keywords: Fisheries ; Histamines ; Quality control ; Fisheries
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 15
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    Un estudio de la factibilidad del uso de trampas para peces como un nuevo método de pesca en las Islas Galápagos (2009)
    INP (Ecuador)
    Details
    Publication Date: 2021-05-19
    Description: 153 experimental sets were made with stackable Antillean fish traps in depths of 5 to 30 m in the waters around the Galápagos Island (Ecuador), between Octobre and April 1983. 1,885 fish were caught of 18 species mainly of the families Pomadasyidae, Acanthuridae, Sparidae and Serranidae. The mean catch rate was 5,5 Kg per lift or 0,4 Kg.h-1, and the mean weight of the fish caught was 0,45 Kg. The optimum set duration was found to be between 2 and 18 hours (possibly indicating a high rate of escape). This study took place during the period of the ”El Niño”, when catches of fish in this area generally were low, and it is not known what effect this had. The catches were good compared with other shallow areas, but the fishes caught were mainly of medium quality. It is thought that significant increases in the quantity and quality of the catch could be obtained with commercial traps in deeper areas, but the efficient use of these would require new vessels and equipment, and the resulting increase in fishing effort could lead to overfishing of the most acceptable species of reef fish. Hence the development of fishery using fish traps is not recommended for Galápagos. A study of the biology of the fish caught was carried out. A bibliography of references on fish traps and their use was compiled and is included.
    Description: Published
    Keywords: Fisheries ; Trap fishing ; Fisheries ; Catch statistics ; Trap fishing
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  • 16
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    Emptying the Ocean: The threatened fisheries of West Africa (2005)
    Details
    Publication Date: 2021-05-19
    Description: The coastal waters of West Africa are among the world's richest fishing grounds ... for the time being. Droughts have ravaged the hinterland and as a result people have steadily moved towards the shores of Senegal and Mauritania. At the same time the international fishing industry seems intent on exploiting West African waters to a greater and greater extent. Nicolien Zuijdgeest and photographer Bas Beentjes visited the region and found that the sustainability of fisheries is being seriously threatened.
    Description: Published
    Keywords: Fisheries
    Repository Name: AquaDocs
    Type: Journal Contribution , Non-Refereed , Article
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  • 17
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    Gestion des Peches, de la Biodiversite et de L’environnement au Gabon (2005)
    Fishbase
    Details
    Publication Date: 2021-05-19
    Description: Le Gabon est situé en Afrique centrale avec une façade atlantique . Il est limité au Nord par le Cameroun, au Nord-ouest par la Guinée Equatoriale, à l’Est et au Sud par le Congo. La zone économique exclusive (ZEE) a une surface de 213.000 Km². elle est plus vaste que celle de Sao-Tomé et Principé, pays insulaire voisin (160.000 Km²). La façade maritime à une longueur de 750 Km , de Coccobeach à Ndindi. La largeur moyenne du plateau continental est de 60 Km, soit une surface à peu-près de 40.600 Km² de la côte à l’isobathe de 200 mètres. Ce plateau se termine par un talus peu abrupt, d’une longueur de 750 Km et d’une superficie de 11.200 Km² entre 200 et 800 mètres de profondeur....
    Description: Unpublished
    Keywords: Biodiversity ; Environments ; Fisheries
    Repository Name: AquaDocs
    Type: Working Paper , Non-Refereed
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  • 18
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    Biodiversity, Trade, And The Fishing Sector Case Study: West Africa (2005)
    Details
    Publication Date: 2021-05-19
    Description: In 1997, IUCN-The World Conservation Union, with the financial support of the German Federal Ministry for Economic Co-operation and Development, initiated a project to examine the relationship between the Convention on Biological Diversity (CBD) and the rules of international trade–those administered by the World Trade Organisation (WTO), in particular. The project was motivated by a widely shared concern that the aims of the CBD, which are essentially to conserve and equitably distribute the benefits of the environment, might be undermined by the WTO, which aims at the liberalisation of trade. Liberalised trade has the potential to integrate economies, regionally and globally, in mutually beneficial ways. But some observers are concerned that it may do so at a cost of impairing the environment and amplifying disparities in wealth, much of which, in poorer nations, is disproportionately represented in endowments of natural resources. Other commentators have claimed to locate synergistic potential, suggesting, for example, that trade law’s anti-subsidy disciplines might be conscripted into the campaign against environmental abuses such as overfishing.
    Keywords: Biodiversity ; International trade ; Fisheries
    Repository Name: AquaDocs
    Type: Conference Material , Non-Refereed , Paper
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    Marine biological research in Mozambique: past, present and future (2005)
    Royal Academy of Sciences
    Details
    Publication Date: 2021-05-19
    Description: This synopsis describes the development of marine biological research, including fisheries, in Mozambique. With around 3000 km of coastline, the living resources of the sea playa major role in the Mozambican society, mainly as a source of protein and income for the population, and of foreign revenue through exports. In the first years, after independence, in 1975, research activities in marine sciences were limited and mainly concentrated to fisheries through cooperation with Norway and the Soviet Union. A new era for biology started in 1985 when the Faculty of Biology at Universidade Eduardo Mondlane was re-opened. A 5yr curriculum towards a licentiate degree was introduced with a strong marine profile. Since the 1990s, a very dynamic de-velopment in Mozambican marine biological research has occurred. Several academic degrees in marine biology from universities abroad were obtained, and local expertise developed; building vital institutions and enrolling in advanced research activities.
    Description: Published
    Keywords: Marine biology ; Fisheries
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
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    Feeding partitioning among tuna taken in surface and mid-water layers: the case of yellowfin (Thunnus albacares) and bigeye (T. obesus) in the Western Tropical Indian Ocean (2006)
    WIOMSA
    Details
    Publication Date: 2021-05-19
    Description: The trophic relations of two apex predators, yellowfin and bigeye tuna (Thunnus albacares and T. obesus), and their prey were investigated in the western tropical Indian Ocean. The contents of 173 non-empty stomachs were analysed from specimens caught with longlines and purse seine during scientific and fishing cruises. Diet data were processed by occurrence, by number, and by wet weight and a comparison of diets between surface and deep swimmers made. Crustaceans were the almost exclusive food source of surface-swimming bigeye tuna, with the stomatopod (Natosquilla investigatoris) being the sole prey item recorded in this category. The diet of deep-swimming yellowfin tuna was balanced between epipelagic fish, crustaceans and cephalopods. Bigeye tuna fed predominantly on cephalopods and mesopelagic fish (Scopelarchidae and Paralepididae), for which this predator appeared to be the most active chaser. The diet of the two predators reflects their ability to catch the prey, and their vertical distribution.
    Description: Published
    Description: Natosquilla investigatoris; Thunnus albacares; T. obesus; Feeding ecology; Vertical habitat
    Keywords: Tuna ; Fisheries ; Diets ; Tuna fisheries ; Analysis
    Repository Name: AquaDocs
    Type: Journal Contribution , Non-Refereed , Article
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    Different property rights regimes in the Lake Victoria multiple species fishery (2006)
    Details
    Publication Date: 2021-05-19
    Description: Greater ecosystem complexity is recognized by studying a two species predator-prey model under two property rights regimes: free entry and a system such as individual quotas which execute an economically optimal solution. A bottom-up management experiment is discussed in the context of Lake Victoria fisheries.
    Description: Published
    Keywords: Predators ; Resource management ; Fisheries ; Freshwater fish ; Predators ; Resource management
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
    Format: 71093 bytes
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    Résultats généraux des pêches maritimes 2005 (2008)
    Details
    Publication Date: 2021-01-30
    Description: This document presents the Senegalese maritime fishing statistics in 2005 with the catch from the artisanal fisheries, the industrial fisheries as well as exports and the value of commercial coating.The document also informs on the number of estimated canoes , the estimated number of fishermen, consumption of fresh fish product and processed products. The document also shows fisheries statistics by marine areas.
    Description: Ministère de l'Economie Maritime, Direction des Pêches Maritimes, Dakar (Sénégal)
    Description: Published
    Description: statistique, pêche artisanale, pêche industrielle, commercialisation, pêche maritime, pêche par espéce
    Keywords: Demersal fisheries ; Fisheries ; Marine fisheries ; Pelagic fisheries ; Commercial fishing ; Artisanal fishing ; Cephalopod fisheries ; Demersal fisheries ; Fisheries ; Fishery statistics ; Fishing vessels statistics ; Marine fisheries ; Mollusc fisheries ; Pelagic fisheries ; Shrimp fisheries
    Repository Name: AquaDocs
    Type: Report
    Format: 110
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    Rapport national sur l'état de l'environnement marin et côtier (2009)
    Details
    Publication Date: 2021-01-30
    Description: Le domaine maritime sénégalais s’étend de 18°00 N, -20°00 W, -16°30 E, 12°15 S ; la presqu’île du Cap-Vert située entre 14°30 N et 15°00 N le divise en deux zones aux caractéristiques topographiques distinctes. Au nord, le plateau continental est peu étendu vers le large et orienté Nord-Nord/Est. Au sud de la presqu’île, le plateau s’élargit et le talus continental est orienté nord-sud. L’embouchure du fleuve Sénégal au Sénégal au Nord de la presqu’île du Cap-Vert et celles de la Gambie et de la Casamance au Sud constituent également un trait marquant de cette région. Les travaux réalisés au Sénégal en océanographie ont montré : - l’existence de deux saisons marines aux caractéristiques très différentes qui se succèdent : une saison chaude de juillet à octobre et une saison froide de décembre à mai. Ces deux saisons sont séparées par des périodes de transition. Pendant la saison froide, les alizés (vent de secteur nord-ouest à nord-est) s’établissent et engendrent à la côte une résurgence d’eau profonde (upwelling) vers la surface ; - la mise en évidence de systèmes de grands courants aux caractéristiques différentes : le courant des Canaries et le contre courant équatorial ; - la description de trois grandes houles au large du Sénégal : o la houle de Nord-Nord ouest qui a lieu toute l’année o la houle de Sud-Sud ouest apparaissant pendant l’hivernage o la houle d’ouest possible aux environs du mois de novembre. Le littoral sénégalais représente une zone d’intérêt stratégique à la fois sur le plan démographique, économique et environnemental. Les milieux naturels, dans un état de conservation relativement préservé, produisent des ressources vitales pour les 11 millions d’habitants peuplant le Sénégal. L’économie nationale sénégalaise est très dépendante de ces ressources côtières et marines qui constituent les principales recettes en devises, qu’il s’agisse de pêche ou de tourisme. L’analyse de la situation et des tendances montre que la zone côtière fait l’objet de pressions diversifiées et de plus en plus lourdes. Ces pressions se traduisent souvent par des conflits d’intérêts entre les différents secteurs et par des impacts qui génèrent une dégradation de l’environnement et des conditions de vie des populations. Cette évolution risque ainsi de compromettre les potentialités de développement offertes par les 700 Km de littoral sénégalais. La pression démographique se développe préférentiellement sur la zone côtière qui accueille déjà près de 60% des habitants, notamment dans les centres urbains et les capitale, toutes situées en bord de mer, et qui continuent à recevoir des populations en provenance de l’intérieur, réfugiés climatiques ou économiques, ou simplement jeunesse attirée par les « lumières de la ville ». Cet exode, à l’origine de dysfonctionnements des systèmes de production ruraux qui manquent peu à peu de main d’oeuvre, contribue à son tour à générer des perturbations au niveau des centres urbains où la misère se substitue parfois à la pauvreté.
    Description: Les besoins en matériaux de construction consécutifs à cette évolution démographique entraînent des prélèvements massifs de sable sur les plages qui ont à leur tour des conséquences négatives sur l’érosion et la protection du littoral. La fragilisation des cordons dunaires augmente ainsi les risques d’inondations des terres, la ville de Saint Louis étant particulièrement vulnérable à cet égard. Les besoins en développement ont conduit à la réalisation d’infrastructures le long du littoral. Ces constructions, qui tiennent trop rarement compte des contraintes environnementales, ont entraîné des répercussions structurelles sur l’équilibre de la zone côtière. Ainsi, les barrages anti-sel, tel le barrage de Diama sur le fleuve Sénégal, ont entraîné des répercussions sur le fonctionnement de certains écosystèmes côtiers. En condamnant les influences des apports d’eau douce ils appauvrissent les milieux situés en aval, stérilisant peu à peu des zones riches en ressources ainsi que les économies et les cultures qui en dépendent. Le ralentissement des courants et la baisse de salinité en amont du barrage favorisent l’apparition de certaines plantes envahissantes, telles que la bilharziose ou le paludisme. Les effectifs de poissons dépendant de milieux à salinité variable sont directement affectés, expliquant par exemple une chute de près de 70% des captures dans le bas delta du Sénégal. Les besoins du développement se traduisent également par l’amélioration ou la création d’axes routiers qui, dans la majorité des cas, longent la zone côtière. Ces ouvrages entraînent des impacts directs sur l’environnement, tels la destruction des mangroves là où les routes barrent l’écoulement des marées (exemple de la route Samba Dia – Djifère. Les systèmes de production traditionnels sont en règle générale peu préparés à faire face à des circuits de commercialisation organisés à une échelle régionale ou internationale, où à des technologies plus performantes, et éprouvent des difficultés à maintenir un contrôle sur leur terroir. Faute de pouvoir opérer une métamorphose rapide de leur système de production, le risque existe de voir peu à peu disparaître des savoir-faire d’une grande valeur dans la gestion même de ces territoires et de leurs ressources et , plus généralement, des cultures qui leur sont associées. Le développement industriel exerce des impacts potentiels ou réels de grande magnitude sur la zone côtière et marine. Les secteurs les plus significatifs à cet égard sont le tourisme et les hydrocarbures. Concernant le premier, les infrastructures, principalement orientées vers le tourisme balnéaire, sont en grande majorité installées à proximité directe de la zone côtière. L’absence quasi généralisée d’études d’impacts approfondies et indépendantes a conduit à de nombreux échecs. Ainsi, la plupart des projets ont été pensés et réalisés sans tenir suffisamment compte des contextes socio-économiques, culturels et environnementaux dans lesquels ils s’insèrent. Certaines réalisations ont été planifiées sur des secteurs soumis à une forte érosion littorale, compromettant de façon irrémédiable non seulement les investissements mais l’utilisation ultérieure du site, comme cela s’est produit sur les plages au sud immédiat du Cap Skirring. Les questions relatives à la disponibilité en eau douce qui se posent de façon cruciale dans le Saloum par exemple, à la gestion des déchets et des eaux usées ne sont que rarement prises en considération de façon structurelle et durable, conduisant à la dégradation de l’environnement ou à des conflits avec les communautés locales qui nuisent à la qualité même du tourisme. L’exploration et l’exploitation des ressources en hydrocarbures représentent aussi un secteur d’intérêt stratégique avec une généralisation des prospections. Si la découverte de gisement d’intérêt commercial représente une opportunité majeure pour l’économie nationale, elle soulève néanmoins un certain nombre de questions au regard de l’environnement. En effet les des puits. Parmi ces risques nous pouvons citer les impacts des études sismiques sur les organismes marins, notamment poissons et cétacés, le rejet de fluides toxiques et déblais de forage, le déversement des eaux de production et les pollutions aiguës dues à des accidents intervenant pendant le forage, le stockage ou le transport. Le Sénégal en ce moment, en est au stade de la prospection. Toutefois, pour ce qui concerne le transport d’hydrocarbures, plus de 90 000 0000 de tonnes d’hydrocarbures transitent par les côtes sénégalaises. Les modèles de dérive des nappes élaborés par la Compagnie pétrolière Woodside en relation avec le champ de Chinguetti, actuellement en cours de production au large de la Mauritanie, montrent des probabilités d’impact sur les côtes allant du golfe d’Arguin jusqu’à Dakar, en cas d’accident. La surexploitation des ressources halieutiques constitue également un problème au niveau de l’environnement marin et côtier. En effet, si une partie de la fluctuation des biomasses peut s’expliquer par les changements du régime des upwellings, la baisse des captures s’explique par un effort de pêche excessif, que ce soit dans le sous-secteur industriel ou artisanal. A cette surcapacité vient s’ajouter la présence de flottes illicites non déclarées et non réglementées. L’utilisation de certains engins ou pratiques de pêche contribue à aggraver la situation : la pêche crevettière est à l’origine de prises accidentelles qui représentent jusqu’à 85 % du total des captures, incluant des espèces protégées comme les tortues marines, et qui sont rejetés à la mer . Les chaluts de fonds, qui vont pêcher jusqu’à 800 m de profondeur, ainsi que les dragues à coquillages entraînant des dégâts structurels sur les écosystèmes De plus l’influence des marchés à l’exportation exerce des pressions sélectives sur certaines espèces, les espèces démersales de poissons, céphalopodes étant les plus recherchées sur le marché. Les changements climatiques ont également des impacts négatifs sur l’environnement marin et côtier. On sait que l’élévation du niveau marin aura des répercussions directes sur les installations humaines littorales ainsi que sur les écosystèmes insulaires et côtiers. Des zones de mangroves entières qui ne disposent pas des conditions écologiques pour s’adapter peuvent disparaître, entraînant des risques accrus d’érosion et d’inondation. Ces mêmes risques se multiplient avec la fréquence accrue des épisodes météorologiques exceptionnels tels que les ondes de tempêtes capables de drosser les pirogues à la côte ou de provoquer la rupture de cordons dunaires. On sait par ailleurs que le réchauffement de la température des mers influe négativement sur la productivité des océans et la dynamique des courants tels que le courant profond originaire de l’antarctique et qui exporte vers le Sénégal et les autres pays de la sousrégion des sels nutritifs présents dans les upwellings. On observe également une diminution de la puissance des alizés qui pourrait avoir des répercussions directes sur la force des upwellings et donc sur la productivité des pêcheries et du milieu marin en général. La stratégie de réponse proposée combine une protection des zones côtières importantes et un reboisement des dunes littorales dans les secteurs de la côte nord et de la Flèche de Sangomar particulièrement menacés. L’évaluation économique de cette stratégie montre qu’elle est coûteuse mais nettement en deçà de la valeur économique des terres qu’elle sera amenée à protéger. Des efforts complémentaires devront cependant être faits pour évaluer le coût d’autres solutions de protection telles que le nourissement artificiel des plages. Par ailleurs, la stratégie envisagée ne répondant qu’à l’un des impacts des changements climatiques, à savoir les inondations, toute une série de mesures dites d’accompagnement ont été suggérées qui visent à diminuer la vulnérabilité en gérant mieux les ressources présentes dans la zone côtière, en développant les techniques de récupération des sols salés et en prenant des mesures législatives et institutionnelles appropriées. Enfin, il est très important de souligner que ces différentes mesures ne devraient être envisagées que dans un cadre plus global de gestion intégrée des zones côtières, seul à même d’assurer la participation de l’ensemble des acteurs concernés, l’éducation, la recherche et l’information environnementales mais aussi la cohérences et le suivi des mesures.
    Description: Ministère de l'Environnement, de la Protection de la Nature, des Bassins de Rétention et des Lacs Artificiels, Dakar (Sénégal)
    Description: Published
    Description: écosystéme marin; technique de pêche; filet; érosion côtière; pollution; pêche; flore; environnement; migration; pêcheur; oiseau d'eau; tortue marine; lamantin; requin; mammifére marin; réglementation; mangrove; écosystème; estuaire; delta
    Keywords: Deltas ; Ecosystems ; Marine environment ; Aquatic birds ; Fishermen ; Fisheries ; Mangroves ; Coastal erosion ; Flora ; Fishing nets ; Deltas ; Ecosystems ; Mangroves ; Coastal erosion ; Marine environment ; Marine mammals ; Shark fisheries ; Turtle fisheries ; Aquatic birds ; Fishermen ; Migrations ; Flora ; Fisheries ; Marine pollution ; Fishing nets ; Climatic changes
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
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    Résultats généraux de la pêche maritime sénégalaise 2002 (2007)
    Details
    Publication Date: 2021-01-30
    Description: Published
    Description: pêche par espéce; crustacé
    Keywords: Fisheries ; Artisanal fishing ; Capture fishery economics ; Fisheries ; Fishery statistics
    Repository Name: AquaDocs
    Type: Report
    Format: 1546887 bytes
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    Format: 122
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    The Fisheries of Eritrea (2005)
    FAO
    Details
    Publication Date: 2021-01-30
    Description: Published
    Description: Eritrea
    Keywords: Fisheries
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
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    From Farming to Fishing: Marine Resource Conservation (2009)
    Western Indian Ocean Marine Science Association
    Details
    Publication Date: 2021-05-19
    Description: This paper examines the arrival of a new group of fishermen on the Kenyan coast and what this has meant for the state of fishery resources. It reviews four subject areas: access and the number of fishermen; the fishermen’s identity; the choice of fishing gear; and the fishing grounds selected. Data were collected from a small number of fishing households in the villages of Uyombo and Takaungu in Kilifi District, using mainly qualitative research methods. Local households on the Kenyan coast face increasing pressure on land as well as on marine resources. The declining economic situation and greater pressure on land have made people turn to fishing as an income-generating activity. This group of fishermen is referred to as the ‘new’ generation of fishermen as they have been involved in fishing for only one or two generations (including the current one) in contrast to the ‘old’ generation from families who have been fishing or in fishingrelated activities for much longer. The old generation of fishermen and their households have also diversified their incomes, with many fishing households turning to farming, for example, with women and grown-up children involved in various activities. The new generation of fishermen, mainly of the Mijikenda population group, has often been blamed for the loss of traditional access regulations and for using harmful fishing gear. This paper discusses the new generation of fishermen and their identity as they perceive it and relates this to employment generation as a policy measure for marine conservation.
    Description: Published
    Description: Artisanal fisheries;household survey; income diversification; marine conservation,
    Keywords: Fisheries ; Fishery resources ; Fisheries ; Fishery resources
    Repository Name: AquaDocs
    Type: Journal Contribution
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    Rapport de la septième rencontre de travail IMROP/IEO pour l’étude des pêcheries de crustacés. (2005)
    IMROP/IEO
    Details
    Publication Date: 2021-05-19
    Description: Cette rencontre entre dans le cadre du programme conjoint de recherche sur les crustacés entre l’IMROP et l’IEO (Espagne)
    Description: Published
    Keywords: Captures ; Effort de pêche ; Length distribution ; Fishing effort ; CPUE ; Débarquement ; Landing ; Pêcheries ; Mauritanie ; Fisheries ; Accords de pêche ; UE ; Mauritania ; Crevettes ; Shrimps ; EU ; Distribution de taille ; Fishing fleet ; Fishing agreements ; Flottille de pêche ; Catches ; Crustacean fisheries
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
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    Fish for Thought: Fisheries, International Trade and Sustainable Development (2005)
    International Centre for Trade and Sustainable Development (ICTSD) and IUCN-The World Conservation Union
    Details
    Publication Date: 2021-05-19
    Description: The Fisheries, International Trade, and Sustainable Development programme aims to inject both the sustainable development and natural resource management perspectives into the debate on trade and fisheries. The ultimate objective of the programme is to make international trade in fisheries supportive of sustainable development. The programme's main activity will be to convene a series of policy dialogues on fisheries, international trade, and sustainable development which will link processes and actors, and bring together all the different stakeholders' perspectives. Initially the programme aims to facilitate a process in which each stakeholder can move beyond the constraints inherent in his or her position, to enable all participants to step back from particular debates and stand-offs regarding fisheries, trade, and sustainable development-related issues such as subsidies, ecolabelling, or conservation measures. The dialogues, research, and information exchange process will seek to build common understanding and a baseline of shared information, and pave the way for participating stakeholders to seek solutions compatible with the aims of sustainable development by exploring ways to improve resource management while safeguarding the livelihoods of those who depend on fisheries, and ensuring economic growth for developing countries.
    Description: International Centre for Trade and Sustainable Development, IUCN — The World Conservation Union Publications Service Unit
    Description: Published
    Keywords: Sustainable development ; Fisheries ; International trade
    Repository Name: AquaDocs
    Type: Book Section , Non-Refereed
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    Ecological and fisheries development of Lake Manzalah (Egypt): hydrography and chemistry of Lake Manzalah (2006)
    Alexandria: National Institute of Oceanography and Fisheries
    Details
    Publication Date: 2021-05-19
    Description: This journal is published by the NIOF, Egypt
    Description: Lake Manzalah; the largest delta Lake in Egypt represents a dynamic system that has been undergoing continuous and pronounced changes since long times. In the last year’s this Lake faced drastic problems that retarded its environmental and fisheries development; the most serious one is the discharge of waste water. It is attempted in the present study to investigate the chemical characters of Lake Manzalah water during 2001-2002. Water temperature ranged from an average of 12.35oC in January and 29.14oC in July. Dissolved Oxygen, pH and total dissolved solids were found in ranges optimum for the living of marine and freshwater fish species. The average concentrations of nutrients lied in the following ranges: 1.24 to 4.89 μmol PO4 -3 l-1 , 5.08 to 28.73 μmol SiO4 -2 l-1 and 1.81 to 17.7 μ_mol NO3-1 l-1 The concentrations of phosphorus and nitrogen compounds were found to be relatively higher at the southern regions of the Lake near to the outlets of the drains.
    Description: NIOF
    Description: Published
    Keywords: Hydrography ; Water ; Chemistry ; Chemical composition ; Water content ; Environment ; Chemical composition ; Environments ; Water content ; Fisheries
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
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    Focus on the Marine fisheries Research Division (2005)
    Accra : Marine Fisheries Research Division
    Details
    Publication Date: 2021-05-19
    Description: Ministry of Food and Agriculture
    Description: Directorate of Fisheries
    Description: Published
    Description: Exploitation, Upwelling, Pelagic species, Demersal species, Atlantic Ocean
    Keywords: Fishery policy ; Marine environment ; Fisheries ; Exploitation
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
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    Modelling the economics of ecosystem services: nutrient retention in wetlands and fisheries in Lake Victoria (2006)
    Details
    Publication Date: 2021-05-19
    Description: This paper models the effect of changes in wetlands yields within the freshwater fishery of (the Kenyan segment) of Lake Victoria. Specifically, it models the nutrient retention function of wetlands as a buffer against fertilizer run-off from agriculture, and the impact of nutrient loading on the fishery. Run-off from the watershed is among the major causes of eutrophication in the lake, along with atmospheric deposition and sewage and other organic discharges from domestic and industrial activities. The ecological component of the model captures the interactions between phosphorus loading, wetland area, water quality and fish stocks. Chlorophyll-a concentration is used as a proxy for phytoplankton density, and as a measure of nutrient enrichment. The impact of this on fish stocks is then estimated using using Ecopath. The economic component of the model then evaluates the effect of changes in stocks on performance in the fishery, given the regulatory regime in Kenya. We use the results to obtain an estimate of the value of the nutrient retention function of wetlands on the margins of the lake.
    Description: Published
    Keywords: Valuation of ecosystem services ; Ecological-economic interactions ; Fisheries ; Eutrophication ; Fishery resources ; Ecosystems ; Fishery resources ; Wetlands
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
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    The industrial tuna fishing activity in the Western Indian Ocean: report for the year 2001 (2006)
    Victoria: Seychelles Fishing Authority | Victoria
    Details
    Publication Date: 2021-08-09
    Description: Published
    Description: Industrial tuna fishing
    Keywords: Tuna ; Fisheries ; Fishery economics ; Fishery industry ; Fishery statistics ; Tuna fisheries
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
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    African Fisheries: Major Trends and Diagnostic of the 20th Century. (2005)
    IIFET
    Details
    Publication Date: 2021-05-19
    Description: The marine fisheries production from African coastal countries, combined with that of freshwater production of the continent is estimated to be 6 millions metric tons, corresponding only 5 % of the total world production. Africa's contribution to fisheries products (1,5 %) is insignificant compared to that of world commerce which is around 44 millions tons. This deplorable situation is due to a certain number of problems which include s among others, the relative biogenic poverty of African waters, the exploitation of African waters by foreign vessels, the total lack of catches effected by the African vessels out of their regional boundaries, the lack of knowledge on the mastering of commercialisation and on veritable commercial politics of fisheries products, including quality assurance. In addition to this, the almost inexistence of the aquaculture in the sub-Saharan countries. This paper analyses the African fisheries in the whole continent and presents the general characters, notably its evolution, fisheries resources, valorisation and consumption of fisheries products. The global analysis made here accords a priority to markets as well as to the framework of contribution of these products and tries, at the end of the 20th century, to present some trends. Facing the globalisation phenomena, how will African fisheries producers be challenged in the new millennium? This continental level analysis brings out field application and some different development perspectives for both small scale and industrial fisheries sub-sectors.
    Description: Published
    Keywords: Fisheries
    Repository Name: AquaDocs
    Type: Proceedings Paper , Non-Refereed
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    Kenyan Exports of Nile Perch: impact of food safety standards on an export-oriented supply chain. (2006)
    Details
    Publication Date: 2021-05-19
    Description: Over the past decade, exports of fish and fishery products from developing countries have increased rapidly. However, one of the major challenges facing developing countries in seeking to maintain and expand their share of global markets is stricter food safety requirements in industrial countries. Kenyan exports of Nile perch to the European Union provide a notable example of efforts to comply with such requirements, overlaid with the necessity to overcome restrictions on trade relating to immediate food safety concerns. Although food safety requirements were evolving in their major markets, most notably the EU, most Kenyan exporters had made little attempt to upgrade their hygiene standards. Likewise, the legislative framework of food safety controls and facilities at landing sites remained largely unchanged. Both exporters and the Kenyan government were forced to take action when a series of restrictions were applied to exports by the EU over the period 1997 to 2000. Processors responded by upgrading their hygiene controls, although a number of facilities closed, reflecting significant costs of compliance within the context of excess capacity in the sector. Remaining facilities upgraded their hygiene controls and made efforts to diversify their export base away from the EU. Legislation and control mechanisms were also enhanced. Hygiene facilities at landing beaches were improved, but remain the major area of weakness. The Kenyan case illustrates the significant impact that stricter food safety requirements can have on export-oriented supply chains. It also demonstrates how such requirements can exacerbate existing pressures for restructuring and reform, while prevailing supply and capacity issues constrain the manner in which the supply chain is able to respond. In Kenya most of the concerted effort to comply with these requirements was stimulated by the sudden loss of market access in very much a “crisis management” mode of operation, illustrating the importance of responding to emerging food safety requirements in a proactive and effective manner. This paper - a product of the International Trade Department, Poverty Reduction and Economic Management Network - is part of a larger effort in the network to understand the challenges and opportunities facing developing countries associated with evolving international standards for food and other products.
    Description: Published
    Keywords: Development economics ; Private sector ; Public Policy Fishing Industry ; Environmental economics & policies ; Fisheries ; Agricultural Knowledge & Information Systems ; Agribusiness & Markets ; Coastal and marine resources ; Fishery management ; Fishery products ; Fishery resources ; Food availability ; Aquaculture development ; Aquaculture economics ; Fishery economics ; Fishery management ; Fishery products ; Food availability
    Repository Name: AquaDocs
    Type: Working Paper , Non-Refereed
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  • 35
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    Résultats généraux de la pêche maritime sénégalaise 2001 (2007)
    Details
    Publication Date: 2021-01-30
    Description: Published
    Description: pêche artisanale; pêche industrielle; pêche par espéce
    Keywords: Fishery oceanography ; Fisheries ; Fishery economics ; Fishery statistics ; Fishery oceanography ; Commercial fishing ; Artisanal fishing ; Fish catch statistics ; Fisheries
    Repository Name: AquaDocs
    Type: Report
    Format: 792055 bytes
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    Format: 129 pp
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  • 36
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    Résultats généraux des pêches maritimes 2004 (2008)
    Details
    Publication Date: 2021-01-30
    Description: This document presents the Senegalese maritime fishing statistics in 2004 with the catch from the artisanal fisheries, the industrial fisheries as well as exports and the value of commercial coating.The document also informs on the number of estimated canoes , the estimated number of fishermen, consumption of fresh fish product and processed products. The document also shows fisheries statistics by marine areas.
    Description: Ministère de l'Economie Maritime et des Transports Maritimes Internationaux, Direction des Pêches Maritimes, Dakar (Sénégal)
    Description: Published
    Description: statistique, pêche artisanale, pêche industrielle, commercialisation, pêche maritime, pêche par espéce
    Keywords: Fisheries ; Demersal fisheries ; Marine fisheries ; Marine resources ; Marketing ; Coastal fisheries ; Pelagic fisheries ; Multispecies fisheries ; Artisanal fishing ; Fish catch statistics ; Fisheries ; Coastal fisheries ; Demersal fisheries ; Pelagic fisheries ; Marine fisheries ; Marine molluscs ; Marine resources ; Marketing ; Capture fishery economics ; Multispecies fisheries
    Repository Name: AquaDocs
    Type: Report
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  • 37
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    Résultats généraux des pêches maritimes 2006 (2008)
    Details
    Publication Date: 2021-01-30
    Description: This document presents the Senegalese maritime fishing statistics in 2006 with the catch from the artisanal fisheries, the industrial fisheries as well as exports and the value of commercial coating.The document also informs on the number of estimated canoes , the estimated number of fishermen, consumption of fresh fish product and processed products. The document also shows fisheries statistics by marine areas.
    Description: Ministère de l'Economie Maritime, Direction des Pêches Maritimes, Dakar (Sénégal)
    Description: Published
    Description: statistique, pêche artisanale, pêche industrielle, commercialisation, pêche maritime,
    Keywords: Fisheries ; Demersal fisheries ; Fishery data ; Marine fisheries ; Coastal fisheries ; Commercial fishing ; Cephalopod fisheries ; Coastal fisheries ; Demersal fisheries ; Fisheries ; Fish catch statistics ; Fishery economics ; Fishery industry ; Fishery data ; Fishery statistics ; Fishing vessels statistics ; Marine fisheries
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  • 38
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    Résultats Généraux de la Pêche Maritime 2000 (2007)
    Details
    Publication Date: 2021-01-30
    Description: Published
    Description: pêche artisanale; pêche industrielle; pêche par espéce; Saint-Louis; Thiès; Louga; Dakar; Ziguinchor
    Keywords: Fishery products ; Fisheries ; Capture fishery economics ; Fishery economics ; Fishery statistics ; Fishery products ; Fisheries ; Artisanal fishing
    Repository Name: AquaDocs
    Type: Book
    Format: 950233 bytes
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    Format: 131
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  • 39
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    The "public face" of the New England Regional Fishery Council : year 1 (2007)
    Woods Hole Oceanographic Institution
    Details
    Publication Date: 2022-05-25
    Description: The first year of the New England Regional Fisheries Management Council has been marked by its experimental aura. Neither the Council nor the various sectors (representatives of the Federal and State agencies, members of the fishing industry, the public at large) were clear as to exactly what they were to do and how they were to do it--except in the broadest, most flexible (ambiguous?) terms. This created certain operational difficulties, and confusion for those whose livelihood was affected by the Council's operation. This latter group, particularly the fishermen, knew little of what went on, save in terms of the 'public facet of the Council--i.e., that portion of the Council's performance which occurred during the monthly meetings which were open to the public and which, supposedly, received public input at that time. This study defines that public face, deliberately avoiding the presentation of any data which was not accessible to the average audience participant, in an attempt to present some of the behavior which all participants demonstrated and which generated responses and reactions on the part of the other sectors. It uses standard anthropological techniques of data gathering and analysis to show the degree to which impression management on the part of all the actors operated in a systematic fashion to produce action, reaction, and counter-action. Particularly emphasized is the communication aspects.
    Description: Prepared with funds from the Pew Memorial Trust and by the Department of Commerce, NOAA Office of Sea Grant under Grant #04-7-158-44104, and the Marine Policy and Ocean Management Program of the Woods Hole Oceanographic Institution; and by sabbatical funding from the State University of New York.
    Keywords: Legislation ; Fisheries ; Sociocultural analysis
    Repository Name: Woods Hole Open Access Server
    Type: Technical Report
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    The value of harmful algal bloom predictions to the nearshore commercial shellfish fishery in the Gulf of Maine (2008)
    Details
    Publication Date: 2022-05-25
    Description: Author Posting. © Elsevier B.V., 2008. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Harmful Algae 7 (2008): 772-781, doi:10.1016/j.hal.2008.03.002.
    Description: In this study, we develop a framework for measuring the value of harmful algal bloom (HAB) predictions. The framework captures the effects of both private and public responses to HABs. Using data from the New England nearshore commercial shellfish fishery and impact estimates for a large-scale HAB event in 2005, we illustrate how the potential value of HAB forecasts may be estimated. The results of our study suggest that the long-term value of a HAB prediction and tracking system for the Gulf of Maine is sensitive to the frequency of HAB events, the accuracy of predictions, the choice of HAB impact measures, and the effectiveness of public and private responses.
    Description: This paper is a result of research funded in part by the National Oceanic and Atmospheric Administration’s Coastal Ocean Program under award #NA04NOS4780270 to the Woods Hole Oceanographic Institution.
    Keywords: Harmful algal bloom (HAB) ; Red tide ; Fisheries ; Value of information ; Forecast ; Marine scientific research
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
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    Mission d'enquête sur les populations de lamantins du Fleuve Sénégal: note de synthèse (2008)
    Programme Gestion Intégrée des Ressources Marines et Côtières, Dakar (Senegal)
    Details
    Publication Date: 2021-05-19
    Description: Du 1er au 25 octobre 2006, une enquête auprés des pêcheurs du fleuve Sénégal a été conduite afin de recueillir des informations sur les populations de lamantins notamment entre Podor et Bakel. entre autres résultats, la mission a pu rencontré beaucoup de communautés de pêcheurs et observé le Trichechus senegalensis (nom scientifique de l'espéce). Nous reproduisons quasiment in extenso la note de synthèse que le Chef de mission a bien voulu mettre à la disposition des lecteurs de DIISO
    Description: Published
    Description: lamantin; Trichechus senegalensis
    Keywords: Fisheries ; Surveys ; Surveys ; Fisheries
    Repository Name: AquaDocs
    Type: Journal Contribution
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  • 42
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    Plan directeur de développement forestier pêche et aquaculture continentales (2009)
    Details
    Publication Date: 2021-05-19
    Description: FAO, Rome (Italie);Ministère du Développement et de l'Hydraulique, Dakar (Sénégal)
    Description: Published
    Description: Plan de développement; fôret; pêche; milieu continental; aquaculture; pisciculture ; bilan ; facteur climatique; facteur hydrologique ; facteur socio économique; population rurale; ressources naturelles; poisson d'eau douce; ressources naturelles; gestion de l'environnement; technique de pêche; commercialisation ; consommation; projet de développement
    Keywords: Natural resources ; Fisheries ; Aquaculture ; Marketing ; Development projects ; Forests ; Climatic data ; Hydrology ; Inland water environment ; Aquatic environment ; Development potential ; Fisheries ; Aquaculture ; Marketing ; Development projects ; Fish consumption ; Hydrology ; Inland water environment ; Aquatic environment ; Forests ; Socioeconomic aspects ; Climatic data ; Natural resources ; Freshwater
    Repository Name: AquaDocs
    Type: Book
    Format: 412144 bytes
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    Format: 32
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    Aquatic Sciences and Fisheries Abstracts (ASFA) (2008)
    UNESCO
    Details
    Publication Date: 2021-05-19
    Description: Supported by IOC/IODE
    Description: Document available in English
    Description: ASFA
    Keywords: Fisheries ; Aquatic sciences ; Fisheries ; Abstracts
    Repository Name: AquaDocs
    Format: 15
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  • 44
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    The New England fishing industry : a basis for management (2007)
    Woods Hole Oceanographic Institution
    Details
    Publication Date: 2022-05-26
    Description: Fish and fishermen appear to be in a serious decline in New England. The haddock are overfished, inshore herring stocks are depleted, yellowtail flounder and lobster are scarce. The popular image is of grizzled fishermen, their boats chipped, scarred, old-fashioned hulks of wood tied up two and three abreast along the rotting wharves and piers of New England's depressed port towns. In this research project, we wanted to determine the state of the New England fishing industry and to propose acceptable methods for the management of the fishery. During our early discussions with the fishing industry people, we mentioned that we were interested in limited effort programs as they might be applied to New England fishermen. We carefully, and probably tediously, explained the "theory of limited effort" and we were generally thought to be daft. We were told we had things backwards--that the fishing industry needed more fish, more men, more boats - and that the way to accomplish this was to get a 200-mile fishing limit and kick the foreigners out. One of these wishes has come true - in the spring of 1976, P.L. 94-265 established a 200-mile fishing zone off the United States, with regional management councils to make management plans and allocate the resources first to United States fishermen, with surpluses to foreign fishermen.
    Description: Prepared with funds from the Pew Memorial Trust and by the Department of Commerce, NOAA Office of Sea Grant under Grant #04-5-158-8 and Grant #04-6-158-44106, and the Institution's Marine Policy and Ocean Management Program.
    Keywords: Fisheries ; Management
    Repository Name: Woods Hole Open Access Server
    Type: Technical Report
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  • 45
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    Die Elementarschadenversicherung in der Bundesrepublik Deutschland als Element der finanziellen Risikovorsorge gegen Naturereignisse : Diskussion staatlicher Regulierungsoptionen am Fallbeispiel der Hochwasser 2002 unter Berücksichtigung versicherungswirtschaftlicher Präferenzen (Dissertation, Universität Hannover) (2006)
    Frankfurt am Main : Lang
    In:  Schriften zur politischen Ökonomik, evolutorische und ökologische Aspekte, No. 4
    Details
    Publication Date: 2006
    Keywords: Elementarschadenversicherung ; Natural disaster insurance ; Versicherungspflicht ; Mandatory insurance ; Katastrophenhilfe ; Emergency aid ; Marktversagen ; Market failure ; Überschwemmung ; Flood ; Theorie ; Theory ; Deutschland ; Germany ; Hochschulschrift ; Thesis ; Dissertation
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    BIBLIOGRAPHY FLOODS GERMANY
  • 46
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    Zusammenhang zwischen Klimawandel, Ozon und UV-Strahlung (2008)
    In:  Kappas, M. (Hrsg): Klimawandel und Hautkrebs, Interdisziplinäre Projektgruppe CLIMAderm, Stuttgart, ibidem-Verlag, 25-51
    Details
    Publication Date: 2008
    Keywords: Deutschland ; Umweltmedizin ; UV-Strahlung
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  • 47
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    Klimawandel und Gesundheit: Neuen Aeroallergenen auf der Spur (2009)
    In:  In: BfS/BfR/RKI/UBA (Hrsg.): Klimawandel und Gesundheit. UMID – UmweltMedizinischerInformationsDienst, Ausgabe 3 (Themenheft), Dezember 2009, 13-16
    Details
    Publication Date: 2009
    Description: Beispiele Ambrosia, Eichenprozessionsspinner KATASTER-BESCHREIBUNG: KATASTER-DETAIL:
    Keywords: Deutschland ; Umweltmedizin ; Phänologie
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  • 48
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    Klimawandel: Ausbreitung von Ambrosien und die damit verbundenen Gesundheitsrisiken (2009)
    In:  In: BfS/BfR/RKI/UBA (Hrsg.): Klimawandel und Gesundheit. UMID – UmweltMedizinischerInformationsDienst, Ausgabe 3 (Themenheft), Dezember 2009, 17-20
    Details
    Publication Date: 2009
    Description: ausgedehnte Ambrosiaareale auch in der Lausitz und dem Berliner Raum KATASTER-BESCHREIBUNG: Neben Sensibilisierung gegen Ambrosia auch Kreuzreationen bei Sensibilisierung gegen Beifuß möglich KATASTER-DETAIL:
    Keywords: Deutschland ; Umweltmedizin ; Phänologie
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  • 49
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    Globale Klimaerwärmung und zunehmender Fernreiseverkehr - Ursachen für die Entstehung malariogener Potentiale in Mitteleuropa? Teil I (2006)
    In:  Der Mikrobiologe 16, 178-181
    Details
    Publication Date: 2006
    Description: Autochthone Malaria in Deutschland, Historischer Abriss, Nachkriegsmalaria, Aktuelle malariaepidemiologische Situation KATASTER-BESCHREIBUNG: klimatische Bedingungen ermöglichen Ausreifung von Sporozoiten in heimischen Anophelesmücken, historisch erwiesen KATASTER-DETAIL:
    Keywords: Deutschland ; Umweltmedizin ; Infektionskrankheiten
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  • 50
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    Globale Klimaerwärmung und zunehmender Fernreiseverkehr - Ursachen für die Entstehung malariogener Potentiale in Mitteleuropa? Teil II (2006)
    In:  Der Mikrobiologe 16, 212-216
    Details
    Publication Date: 2006
    Description: Herleitung einer Formel zur Berechnung der Plasmodium-Sporozoitenreifungszeit KATASTER-BESCHREIBUNG: Ausreifung von Pl. vivax- und Pl. falciparum-Sporozoiten im deutschen Raum möglich, Zustandekommen endemischer Malariaerregerübertragung bzw. Entstehung epidemiologisch wirksamer malariogener Potentiale dabei gebunden an das Vorhandensein von Gametozytenträgern und Überträgermücken KATASTER-DETAIL:
    Keywords: Deutschland ; Umweltmedizin ; Infektionskrankheiten
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  • 51
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    Die Auswirkungen des Klimawandels. Welche neuen Infektionskrankheiten und gesundheitlichen Probleme sind zu erwarten? (2009)
    In:  Bundesgesundheitsblatt 2009, 52, 699-714
    Details
    Publication Date: 2009
    Description: einheimische und importierte  vektorassoziierte  Infektionen, Gastrointestinale  Infektionskrankheiten KATASTER-BESCHREIBUNG: KATASTER-DETAIL:
    Keywords: Deutschland ; Umweltmedizin ; Infektionskrankheiten
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  • 52
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    Klimawandel in Deutschland. Vulnerabilität und Anpassungsstrategien klimasensitiver Systeme, Auswirkungen des Globalen Wandels und Anpassungsstrategien in ausgewählten klimasensitiven Systemen, Gesundheit (2005)
    In:  Climate Change, Vol. 08, Umweltbundesamt, Dessau, 122-136
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    Publication Date: 2005
    Keywords: Deutschland ; Umweltmedizin
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  • 53
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    Kosten des Klimawandels. Die Wirkung steigender Temperaturen auf Gesundheit und Leistungsfähigkeit. Eine Studie im Auftrag des WWF Deutschland Frankfurt (2007)
    In:  Institut für Weltwirtschaft, Kiel
    Details
    Publication Date: 2007
    Description: Studie zu einer prognostizierten Anzahl von Tagen mit Wärme- und mit Kältestress, basierend auf Klimaszenarien für den Zeitraum 2071 bis 2100 KATASTER-BESCHREIBUNG: Prognose: größere Zahl an Todesfällen durch Hitze im Süden gegenüber dem Norden Deutschlands und zugleich größerer Rückgang der Todesfälle durch Kälte im Norden, Anstieg der Todesopferzahl durch zunehmende Hitze insgesamt größer als Rückgang der Opferzahl durch weniger Kälte KATASTER-DETAIL:
    Keywords: Deutschland ; Umweltmedizin ; Temperatur
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  • 54
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    Beeinflusst der Klimawandel das Auftreten von Haut- und Allergiekrankheiten in Deutschland? (2008)
    In:  JDDG - Journal der Deutschen Dermatologischen Gesellschaft, 2008, 6(8), 632-639
    Details
    Publication Date: 2008
    Description: Klärung der Studienlage zum potentiellen Einfluss des Klimawandels auf die Prävalenz von Haut- und Allergieerkrankungen in Deutschland KATASTER-BESCHREIBUNG: klimabedingte Veränderungen vor allem bei allergischen Erkrankungen, Hautkrebs und einzelnen erregerbedingten Dermatosen KATASTER-DETAIL:
    Keywords: Deutschland ; Umweltmedizin ; Phänologie ; UV-Strahlung
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  • 55
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    GesundheitlicheAuswirkungen von klimabeeinflussten Luftverunreinigungen (2008)
    In:  In: Lozán, J.L.; Graßl, H.; Jendritzky, G.; Karbe, L.; Reise, K. (Hrsg.) Warnsignal Klima: Gesundheitsrisiken. Gefahren für Pflanzen, Tiere und Menschen.Wissenschaftliche Auswertungen, Hamburg, 121-125
    Details
    Publication Date: 2008
    Description: Fallbeispiel Sommer 2003 KATASTER-BESCHREIBUNG: Zunahme von Ozon in der Troposphäre bei stationären sommerlichen Hochdruckwetterlagen mit hohen Lufttemperaturen und intensiver Sonneneinstrahlung, indirekt Zunahme von Feinstaub bei Hitze (〉30°C) und Ozonbelastung (〉200 Mikrogramm pro Kubikmeter) KATASTER-DETAIL:
    Keywords: Deutschland ; Umweltmedizin ; Luftverunreinigungen
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  • 56
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    Klimawandel und Hautkrebs – Klimafolgenforschung in 21. Jahrhundert (2008)
    In:  Kappas, M. (Hrsg): Klimawandel und Hautkrebs, Interdisziplinäre Projektgruppe CLIMAderm, Stuttgart, ibidem-Verlag, 1-11
    Details
    Publication Date: 2008
    Description: UV-Strahlungsbeeinflussende Faktoren Azimutwinkel, Bewölkung, Aerosole, stratosphärisches Ozon, biologische Wirkung in Abhängigkeit vom Hauttyp und Sensibilisierung (Jahreszeit) KATASTER-BESCHREIBUNG: Einfluss klimatischer Veränderungen auf die Häufigkeit von Hautkrebserkrankungen sehr wahrscheinlich, bei vermutlich hoher Bedeutung des (thermisch motivierten) Expositionsverhaltens KATASTER-DETAIL:
    Keywords: Deutschland ; Umweltmedizin ; UV-Strahlung
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  • 57
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    Surveillance of vector-borne diseases in Germany: Trends and challenges in the view of disease emergence and climate change. (2008)
    In:  Parasitol Res, 103, 11-17
    Details
    Publication Date: 2008
    Description: zeitliche Trends und geografische Ursprünge der Vektor-übertragenen Krankheiten in Deutschland im Hinblick auf Stärken der bestehenden Krankheitsüberwachung für Hantavirus Infektion (endemisch in Deutschland), Chikungunya-Fieber (vor kurzem Schwellenländer in Europa) und Dengue-Fieber (importiert aus tropischen Regionen) KATASTER-BESCHREIBUNG: KATASTER-DETAIL:
    Keywords: Deutschland ; 2001-2007 ; Umweltmedizin ; Infektionskrankheiten
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  • 58
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    Neue Krankheitserreger und ihre Überträger: Klimawandel könnte Gesundheitsgefahren in Deutschland zur Folge haben (2009)
    In:  In: BfS/BfR/RKI/UBA (Hrsg.): Klimawandel und Gesundheit. UMID – UmweltMedizinischerInformationsDienst, Ausgabe 3 (Themenheft), Dezember 2009, 21-23
    Details
    Publication Date: 2009
    Description: weltweite Verbreitung der Asiatischen Tigermücke Aedes albopictus innerhalb der letzten zwei Jahrzehnte im Zusammenhang mit Chikungunya-Ausbruch im Sommer 2007 in Italien KATASTER-BESCHREIBUNG: Transportwege der Globalisierung als wesentlicher Faktor neben Klimaänderungen KATASTER-DETAIL:
    Keywords: Deutschland ; Umweltmedizin ; Infektionskrankheiten
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  • 59
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    Solare UV-Strahlung im Zeichen des erwarteten Klimawandels (2009)
    In:  In: BfS/BfR/RKI/UBA (Hrsg.): Klimawandel und Gesundheit. UMID – UmweltMedizinischerInformationsDienst, Ausgabe 3 (Themenheft), Dezember 2009, 24-28
    Details
    Publication Date: 2009
    Description: Gesundheitliche Bewertung ultravioletter Strahlung KATASTER-BESCHREIBUNG: KATASTER-DETAIL:
    Keywords: Deutschland ; Umweltmedizin ; UV-Strahlung
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    Costs of climate change: The effects of rising temperatures on health and productivity in Germany (2008)
    In:  Ecological Economics 68 (1 – 2), 381–393
    Details
    Publication Date: 2008
    Description: Studie zu einer prognostizierten Anzahl von Tagen mit Wärme- und mit Kältestress, basierend auf Klimaszenarien für den Zeitraum 2071 bis 2100 KATASTER-BESCHREIBUNG: schätzungsweise durchschnittlicher Anstieg der Zahl der wärmeinduzierten Krankheitsfälle um einen Faktor von mehr als 3 und für hitzebedingte Krankenhausaufenthalte 6, Verlust von 0,1% bis 0.5% des BIP durch krankheitbedingten Arbeitsausfall KATASTER-DETAIL:
    Keywords: Deutschland ; Umweltmedizin
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    Klimawandel und Allergie (2008)
    In:  In: Gostomzyk, J.G.; Enke, M. (Hrsg.): Globaler Klimawandel und Gesundheit. Schriftenreihe der Landeszentrale für Gesundheit in Bayern, Band 19, München, 2008, 75 – 85
    Details
    Publication Date: 2008
    Description: Pollensaison, -auftreten und -arten, sowie Veränderungen der Allergenität von Pollen unter Klimawandel KATASTER-BESCHREIBUNG: zunehmende Polysensibilisierungen gegenüber Inhalationsallergien durch zunehmend invasives Traubenkraut Ambrosia artemisiifolia KATASTER-DETAIL:
    Keywords: Deutschland ; Umweltmedizin ; Phänologie
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    Coots use hatch order to learn to recognize and reject conspecific brood parasitic chicks (2009)
    Nature Publishing Group (NPG)
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    Publication Date: 2009-12-18
    Description: Avian brood parasites and their hosts provide model systems for investigating links between recognition, learning, and their fitness consequences. One major evolutionary puzzle has continued to capture the attention of naturalists for centuries: why do hosts of brood parasites generally fail to recognize parasitic offspring after they have hatched from the egg, even when the host and parasitic chicks differ to almost comic degrees? One prominent theory to explain this pattern proposes that the costs of mistakenly learning to recognize the wrong offspring make recognition maladaptive. Here we show that American coots, Fulica americana, can recognize and reject parasitic chicks in their brood by using learned cues, despite the fact that the hosts and the brood parasites are of the same species. A series of chick cross-fostering experiments confirm that coots use first-hatched chicks in a brood as referents to learn to recognize their own chicks and then discriminate against later-hatched parasitic chicks in the same brood. When experimentally provided with the wrong reference chicks, coots can be induced to discriminate against their own offspring, confirming that the learning errors proposed by theory can exist. However, learning based on hatching order is reliable in naturally parasitized coot nests because host eggs hatch predictably ahead of parasite eggs. Conversely, a lack of reliable information may help to explain why the evolution of chick recognition is not more common in hosts of most interspecific brood parasites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shizuka, Daizaburo -- Lyon, Bruce E -- England -- Nature. 2010 Jan 14;463(7278):223-6. doi: 10.1038/nature08655. Epub 2009 Dec 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, California 95064, USA. shizuka@biology.ucsc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20016486" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Birds/*parasitology/*physiology ; British Columbia ; Cues ; Discrimination Learning/*physiology ; Feeding Behavior/physiology ; Genetic Fitness ; Nesting Behavior/*physiology ; Ovum/growth & development ; Pattern Recognition, Visual/physiology ; Survival Rate ; Time Factors ; Wetlands
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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    Reprogramming towards pluripotency requires AID-dependent DNA demethylation (2009)
    Nature Publishing Group (NPG)
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    Publication Date: 2009-12-23
    Description: Reprogramming of somatic cell nuclei to yield induced pluripotent stem (iPS) cells makes possible derivation of patient-specific stem cells for regenerative medicine. However, iPS cell generation is asynchronous and slow (2-3 weeks), the frequency is low (〈0.1%), and DNA demethylation constitutes a bottleneck. To determine regulatory mechanisms involved in reprogramming, we generated interspecies heterokaryons (fused mouse embryonic stem (ES) cells and human fibroblasts) that induce reprogramming synchronously, frequently and fast. Here we show that reprogramming towards pluripotency in single heterokaryons is initiated without cell division or DNA replication, rapidly (1 day) and efficiently (70%). Short interfering RNA (siRNA)-mediated knockdown showed that activation-induced cytidine deaminase (AID, also known as AICDA) is required for promoter demethylation and induction of OCT4 (also known as POU5F1) and NANOG gene expression. AID protein bound silent methylated OCT4 and NANOG promoters in fibroblasts, but not active demethylated promoters in ES cells. These data provide new evidence that mammalian AID is required for active DNA demethylation and initiation of nuclear reprogramming towards pluripotency in human somatic cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906123/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906123/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhutani, Nidhi -- Brady, Jennifer J -- Damian, Mara -- Sacco, Alessandra -- Corbel, Stephane Y -- Blau, Helen M -- AG009521/AG/NIA NIH HHS/ -- AG024987/AG/NIA NIH HHS/ -- AI007328/AI/NIAID NIH HHS/ -- R01 AG009521/AG/NIA NIH HHS/ -- R01 AG009521-25/AG/NIA NIH HHS/ -- R01 AG024987/AG/NIA NIH HHS/ -- R01 AG024987-05/AG/NIA NIH HHS/ -- T32 AI007328/AI/NIAID NIH HHS/ -- U01 HL100397/HL/NHLBI NIH HHS/ -- England -- Nature. 2010 Feb 25;463(7284):1042-7. doi: 10.1038/nature08752.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5175, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20027182" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Fusion ; Cell Line ; Cells, Cultured ; Cellular Reprogramming/genetics/*physiology ; Chromatin Immunoprecipitation ; Cytidine Deaminase/deficiency/genetics/*metabolism ; DNA/chemistry/genetics/metabolism ; *DNA Methylation ; DNA Replication ; Embryonic Stem Cells/cytology/metabolism ; Fibroblasts/cytology/metabolism ; Gene Expression Regulation ; Gene Knockdown Techniques ; Homeodomain Proteins/genetics ; Humans ; Induced Pluripotent Stem Cells/*cytology/enzymology/*metabolism ; Lung/cytology/embryology ; Mice ; Models, Biological ; Octamer Transcription Factor-3/genetics ; Promoter Regions, Genetic/genetics ; Time Factors
    Print ISSN: 0028-0836
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    The sequence and de novo assembly of the giant panda genome (2009)
    Nature Publishing Group (NPG)
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    Publication Date: 2009-12-17
    Description: Using next-generation sequencing technology alone, we have successfully generated and assembled a draft sequence of the giant panda genome. The assembled contigs (2.25 gigabases (Gb)) cover approximately 94% of the whole genome, and the remaining gaps (0.05 Gb) seem to contain carnivore-specific repeats and tandem repeats. Comparisons with the dog and human showed that the panda genome has a lower divergence rate. The assessment of panda genes potentially underlying some of its unique traits indicated that its bamboo diet might be more dependent on its gut microbiome than its own genetic composition. We also identified more than 2.7 million heterozygous single nucleotide polymorphisms in the diploid genome. Our data and analyses provide a foundation for promoting mammalian genetic research, and demonstrate the feasibility for using next-generation sequencing technologies for accurate, cost-effective and rapid de novo assembly of large eukaryotic genomes.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951497/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951497/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Ruiqiang -- Fan, Wei -- Tian, Geng -- Zhu, Hongmei -- He, Lin -- Cai, Jing -- Huang, Quanfei -- Cai, Qingle -- Li, Bo -- Bai, Yinqi -- Zhang, Zhihe -- Zhang, Yaping -- Wang, Wen -- Li, Jun -- Wei, Fuwen -- Li, Heng -- Jian, Min -- Li, Jianwen -- Zhang, Zhaolei -- Nielsen, Rasmus -- Li, Dawei -- Gu, Wanjun -- Yang, Zhentao -- Xuan, Zhaoling -- Ryder, Oliver A -- Leung, Frederick Chi-Ching -- Zhou, Yan -- Cao, Jianjun -- Sun, Xiao -- Fu, Yonggui -- Fang, Xiaodong -- Guo, Xiaosen -- Wang, Bo -- Hou, Rong -- Shen, Fujun -- Mu, Bo -- Ni, Peixiang -- Lin, Runmao -- Qian, Wubin -- Wang, Guodong -- Yu, Chang -- Nie, Wenhui -- Wang, Jinhuan -- Wu, Zhigang -- Liang, Huiqing -- Min, Jiumeng -- Wu, Qi -- Cheng, Shifeng -- Ruan, Jue -- Wang, Mingwei -- Shi, Zhongbin -- Wen, Ming -- Liu, Binghang -- Ren, Xiaoli -- Zheng, Huisong -- Dong, Dong -- Cook, Kathleen -- Shan, Gao -- Zhang, Hao -- Kosiol, Carolin -- Xie, Xueying -- Lu, Zuhong -- Zheng, Hancheng -- Li, Yingrui -- Steiner, Cynthia C -- Lam, Tommy Tsan-Yuk -- Lin, Siyuan -- Zhang, Qinghui -- Li, Guoqing -- Tian, Jing -- Gong, Timing -- Liu, Hongde -- Zhang, Dejin -- Fang, Lin -- Ye, Chen -- Zhang, Juanbin -- Hu, Wenbo -- Xu, Anlong -- Ren, Yuanyuan -- Zhang, Guojie -- Bruford, Michael W -- Li, Qibin -- Ma, Lijia -- Guo, Yiran -- An, Na -- Hu, Yujie -- Zheng, Yang -- Shi, Yongyong -- Li, Zhiqiang -- Liu, Qing -- Chen, Yanling -- Zhao, Jing -- Qu, Ning -- Zhao, Shancen -- Tian, Feng -- Wang, Xiaoling -- Wang, Haiyin -- Xu, Lizhi -- Liu, Xiao -- Vinar, Tomas -- Wang, Yajun -- Lam, Tak-Wah -- Yiu, Siu-Ming -- Liu, Shiping -- Zhang, Hemin -- Li, Desheng -- Huang, Yan -- Wang, Xia -- Yang, Guohua -- Jiang, Zhi -- Wang, Junyi -- Qin, Nan -- Li, Li -- Li, Jingxiang -- Bolund, Lars -- Kristiansen, Karsten -- Wong, Gane Ka-Shu -- Olson, Maynard -- Zhang, Xiuqing -- Li, Songgang -- Yang, Huanming -- Wang, Jian -- Wang, Jun -- R01 HG003229/HG/NHGRI NIH HHS/ -- R01 HG003229-05/HG/NHGRI NIH HHS/ -- England -- Nature. 2010 Jan 21;463(7279):311-7. doi: 10.1038/nature08696. Epub 2009 Dec 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉BGI-Shenzhen, Shenzhen 518083, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20010809" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; China ; Conserved Sequence/genetics ; Contig Mapping ; Diet/veterinary ; Dogs ; Evolution, Molecular ; Female ; Fertility/genetics/physiology ; Genome/*genetics ; *Genomics ; Heterozygote ; Humans ; Multigene Family/genetics ; Polymorphism, Single Nucleotide/genetics ; Receptors, G-Protein-Coupled/genetics ; Sequence Alignment ; Sequence Analysis, DNA ; Synteny/genetics ; Ursidae/classification/*genetics/physiology
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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    Phylogenies reveal new interpretation of speciation and the Red Queen (2009)
    Nature Publishing Group (NPG)
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    Publication Date: 2009-12-17
    Description: The Red Queen describes a view of nature in which species continually evolve but do not become better adapted. It is one of the more distinctive metaphors of evolutionary biology, but no test of its claim that speciation occurs at a constant rate has ever been made against competing models that can predict virtually identical outcomes, nor has any mechanism been proposed that could cause the constant-rate phenomenon. Here we use 101 phylogenies of animal, plant and fungal taxa to test the constant-rate claim against four competing models. Phylogenetic branch lengths record the amount of time or evolutionary change between successive events of speciation. The models predict the distribution of these lengths by specifying how factors combine to bring about speciation, or by describing how rates of speciation vary throughout a tree. We find that the hypotheses that speciation follows the accumulation of many small events that act either multiplicatively or additively found support in 8% and none of the trees, respectively. A further 8% of trees hinted that the probability of speciation changes according to the amount of divergence from the ancestral species, and 6% suggested speciation rates vary among taxa. By comparison, 78% of the trees fit the simplest model in which new species emerge from single events, each rare but individually sufficient to cause speciation. This model predicts a constant rate of speciation, and provides a new interpretation of the Red Queen: the metaphor of species losing a race against a deteriorating environment is replaced by a view linking speciation to rare stochastic events that cause reproductive isolation. Attempts to understand species-radiations or why some groups have more or fewer species should look to the size of the catalogue of potential causes of speciation shared by a group of closely related organisms rather than to how those causes combine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Venditti, Chris -- Meade, Andrew -- Pagel, Mark -- England -- Nature. 2010 Jan 21;463(7279):349-52. doi: 10.1038/nature08630. Epub 2009 Dec 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biological Sciences, University of Reading, Reading, Berkshire, RG6 6BX, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20010607" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; *Genetic Speciation ; *Models, Biological ; *Phylogeny ; Selection, Genetic ; Stochastic Processes
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    Darwin 200: Beneath the surface (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-11-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chouard, Tanguy -- England -- Nature. 2008 Nov 20;456(7220):300-3. doi: 10.1038/456300a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19020592" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Computer Simulation ; Gene Regulatory Networks/genetics/physiology ; Genetic Engineering ; *Genetic Variation ; *Growth and Development/genetics/physiology ; Homeodomain Proteins/genetics/metabolism ; Humans ; *Models, Biological ; Sea Urchins/genetics/growth & development ; Trans-Activators/genetics/metabolism ; Yeasts/genetics/metabolism
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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    Drug discovery: schistosome treatment (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shadan, Sadaf -- England -- Nature. 2008 Mar 20;452(7185):296. doi: 10.1038/452296b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18354470" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthelmintics/*pharmacology/therapeutic use/toxicity ; Antioxidants/metabolism ; Cell Line ; *Drug Evaluation, Preclinical ; Drug Resistance ; Humans ; Mice ; Oxadiazoles/*pharmacology/toxicity ; Praziquantel/pharmacology/therapeutic use/toxicity ; Schistosoma mansoni/drug effects/metabolism ; Schistosomiasis/*drug therapy/*parasitology
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    The role of HLA-DQ8 beta57 polymorphism in the anti-gluten T-cell response in coeliac disease (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-11-28
    Description: Major histocompatibility complex (MHC) class II alleles HLA-DQ8 and the mouse homologue I-A(g7) lacking a canonical aspartic acid residue at position beta57 are associated with coeliac disease and type I diabetes. However, the role of this single polymorphism in disease initiation and progression remains poorly understood. The lack of Asp 57 creates a positively charged P9 pocket, which confers a preference for negatively charged peptides. Gluten lacks such peptides, but tissue transglutaminase (TG2) introduces negatively charged residues at defined positions into gluten T-cell epitopes by deamidating specific glutamine residues on the basis of their spacing to proline residues. The commonly accepted model, proposing that HLA-DQ8 simply favours binding of negatively charged peptides, does not take into account the fact that TG2 requires inflammation for activation and that T-cell responses against native gluten peptides are found, particularly in children. Here we show that beta57 polymorphism promotes the recruitment of T-cell receptors bearing a negative signature charge in the complementary determining region 3beta (CDR3beta) during the response against native gluten peptides presented by HLA-DQ8 in coeliac disease. These T cells showed a crossreactive and heteroclitic (stronger) response to deamidated gluten peptides. Furthermore, gluten peptide deamidation extended the T-cell-receptor repertoire by relieving the requirement for a charged residue in CDR3beta. Thus, the lack of a negative charge at position beta57 in MHC class II was met by negatively charged residues in the T-cell receptor or in the peptide, the combination of which might explain the role of HLA-DQ8 in amplifying the T-cell response against dietary gluten.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784325/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784325/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hovhannisyan, Zaruhi -- Weiss, Angela -- Martin, Alexandra -- Wiesner, Martina -- Tollefsen, Stig -- Yoshida, Kenji -- Ciszewski, Cezary -- Curran, Shane A -- Murray, Joseph A -- David, Chella S -- Sollid, Ludvig M -- Koning, Frits -- Teyton, Luc -- Jabri, Bana -- DK42086/DK/NIDDK NIH HHS/ -- DK55037/DK/NIDDK NIH HHS/ -- DK67180/DK/NIDDK NIH HHS/ -- R01 DK067180/DK/NIDDK NIH HHS/ -- R01 DK067180-04/DK/NIDDK NIH HHS/ -- England -- Nature. 2008 Nov 27;456(7221):534-8. doi: 10.1038/nature07524.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Pathology, Pediatrics and Committee of Immunology, University of Chicago, Chicago, Illinois 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19037317" target="_blank"〉PubMed〈/a〉
    Keywords: Amides/chemistry ; Animals ; CD4-Positive T-Lymphocytes/*immunology ; Celiac Disease/*genetics/*immunology ; Complementarity Determining Regions/chemistry/immunology ; Cross Reactions ; Epitopes, T-Lymphocyte/chemistry/immunology ; Gliadin/chemistry/immunology ; Glutens/chemistry/*immunology ; HLA-DQ Antigens/chemistry/*genetics/immunology ; Humans ; Hybridomas/immunology ; Mice ; Mice, Transgenic ; Polymorphism, Genetic/*genetics ; Receptors, Antigen, T-Cell/chemistry/immunology ; Static Electricity
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    Big data: The future of biocuration (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-09-05
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819144/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819144/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Howe, Doug -- Costanzo, Maria -- Fey, Petra -- Gojobori, Takashi -- Hannick, Linda -- Hide, Winston -- Hill, David P -- Kania, Renate -- Schaeffer, Mary -- St Pierre, Susan -- Twigger, Simon -- White, Owen -- Rhee, Seung Yon -- P41 HG002659/HG/NHGRI NIH HHS/ -- P41 HG002659-07/HG/NHGRI NIH HHS/ -- England -- Nature. 2008 Sep 4;455(7209):47-50. doi: 10.1038/455047a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Zebrafish Information Network, 5291 University of Oregon, Eugene, Oregon 97403-5291, USA. dhowe@cs.uoregon.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18769432" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Science Disciplines/*methods/*trends ; Career Choice ; Computational Biology/education/methods/*trends ; Databases, Factual/*trends/utilization ; Education, Graduate ; Humans ; Information Storage and Retrieval/methods/*trends ; Internet/*trends/utilization ; Publishing/trends
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    Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-05-30
    Description: As alterations in tissue pH underlie many pathological processes, the capability to image tissue pH in the clinic could offer new ways of detecting disease and response to treatment. Dynamic nuclear polarization is an emerging technique for substantially increasing the sensitivity of magnetic resonance imaging experiments. Here we show that tissue pH can be imaged in vivo from the ratio of the signal intensities of hyperpolarized bicarbonate (H(13)CO(3)(-)) and (13)CO(2) following intravenous injection of hyperpolarized H(13)CO(3)(-). The technique was demonstrated in a mouse tumour model, which showed that the average tumour interstitial pH was significantly lower than the surrounding tissue. Given that bicarbonate is an endogenous molecule that can be infused in relatively high concentrations into patients, we propose that this technique could be used clinically to image pathological processes that are associated with alterations in tissue pH, such as cancer, ischaemia and inflammation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallagher, Ferdia A -- Kettunen, Mikko I -- Day, Sam E -- Hu, De-En -- Ardenkjaer-Larsen, Jan Henrik -- Zandt, Rene in 't -- Jensen, Pernille R -- Karlsson, Magnus -- Golman, Klaes -- Lerche, Mathilde H -- Brindle, Kevin M -- C197/A3514/Cancer Research UK/United Kingdom -- England -- Nature. 2008 Jun 12;453(7197):940-3. doi: 10.1038/nature07017. Epub 2008 May 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18509335" target="_blank"〉PubMed〈/a〉
    Keywords: Acid-Base Equilibrium ; Animals ; Bicarbonates/*metabolism ; Carbon Dioxide/metabolism ; Carbon Isotopes ; Carbonic Anhydrases/metabolism ; Catalysis ; Hydrogen-Ion Concentration ; Lymphoma/*diagnosis/*metabolism/pathology ; Magnetic Resonance Imaging/*methods ; Mice ; Neoplasm Transplantation ; Phantoms, Imaging
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    The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-09-30
    Description: Ca(2+)-release-activated Ca(2+) (CRAC) channels underlie sustained Ca(2+) signalling in lymphocytes and numerous other cells after Ca(2+) liberation from the endoplasmic reticulum (ER). RNA interference screening approaches identified two proteins, Stim and Orai, that together form the molecular basis for CRAC channel activity. Stim senses depletion of the ER Ca(2+) store and physically relays this information by translocating from the ER to junctions adjacent to the plasma membrane, and Orai embodies the pore of the plasma membrane calcium channel. A close interaction between Stim and Orai, identified by co-immunoprecipitation and by Forster resonance energy transfer, is involved in the opening of the Ca(2+) channel formed by Orai subunits. Most ion channels are multimers of pore-forming subunits surrounding a central channel, which are preassembled in the ER and transported in their final stoichiometry to the plasma membrane. Here we show, by biochemical analysis after cross-linking in cell lysates and intact cells and by using non-denaturing gel electrophoresis without cross-linking, that Orai is predominantly a dimer in the plasma membrane under resting conditions. Moreover, single-molecule imaging of green fluorescent protein (GFP)-tagged Orai expressed in Xenopus oocytes showed predominantly two-step photobleaching, again consistent with a dimeric basal state. In contrast, co-expression of GFP-tagged Orai with the carboxy terminus of Stim as a cytosolic protein to activate the Orai channel without inducing Ca(2+) store depletion or clustering of Orai into punctae yielded mostly four-step photobleaching, consistent with a tetrameric stoichiometry of the active Orai channel. Interaction with the C terminus of Stim thus induces Orai dimers to dimerize, forming tetramers that constitute the Ca(2+)-selective pore. This represents a new mechanism in which assembly and activation of the functional ion channel are mediated by the same triggering molecule.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597643/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597643/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Penna, Aubin -- Demuro, Angelo -- Yeromin, Andriy V -- Zhang, Shenyuan L -- Safrina, Olga -- Parker, Ian -- Cahalan, Michael D -- P30 CA062203/CA/NCI NIH HHS/ -- R37 NS014609/NS/NINDS NIH HHS/ -- R37 NS014609-29/NS/NINDS NIH HHS/ -- England -- Nature. 2008 Nov 6;456(7218):116-20. doi: 10.1038/nature07338. Epub 2008 Sep 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology and Biophysics, University of California Irvine, California 92697-4561, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18820677" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium Channels/*chemistry/genetics/*metabolism ; Cell Line ; Cross-Linking Reagents ; Drosophila Proteins/*chemistry/genetics/*metabolism ; Drosophila melanogaster/*chemistry/*metabolism ; Humans ; Membrane Proteins/*chemistry/genetics/*metabolism ; Oocytes/metabolism ; Photobleaching ; Protein Multimerization ; Protein Structure, Quaternary ; Xenopus ; Xenopus Proteins/*chemistry/genetics/*metabolism
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    The winding road from ideas to income (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-06-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wadman, Meredith -- England -- Nature. 2008 Jun 12;453(7197):830-1. doi: 10.1038/453830a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18548029" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomedical Research/*economics/*organization & administration ; Drug Evaluation, Preclinical ; Dynamins/antagonists & inhibitors ; Humans ; Intellectual Property ; Patents as Topic ; Research Personnel/economics ; *Technology Transfer
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    Stem cells. A new year and a new era (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-01-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pera, Martin F -- England -- Nature. 2008 Jan 10;451(7175):135-6. doi: 10.1038/451135a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18185576" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Cell Differentiation ; Embryonic Stem Cells/*cytology/metabolism ; Fetus/cytology ; Fibroblasts/cytology ; HMGB Proteins/genetics/metabolism ; Humans ; Kruppel-Like Transcription Factors/genetics/metabolism ; Mice ; Octamer Transcription Factor-3/genetics/metabolism ; Pluripotent Stem Cells/*cytology/*metabolism ; Proto-Oncogene Proteins c-myc/genetics/metabolism ; SOXB1 Transcription Factors ; Transcription Factors/genetics/metabolism
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    Live birth in the Devonian period (2008)
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    Publication Date: 2008-05-30
    Description: The extinct placoderm fishes were the dominant group of vertebrates throughout the Middle Palaeozoic era, yet controversy about their relationships within the gnathostomes (jawed vertebrates) is partly due to different interpretations of their reproductive biology. Here we document the oldest record of a live-bearing vertebrate in a new ptyctodontid placoderm, Materpiscis attenboroughi gen. et sp. nov., from the Late Devonian Gogo Formation of Australia (approximately 380 million years ago). The new specimen, remarkably preserved in three dimensions, contains a single, intra-uterine embryo connected by a permineralized umbilical cord. An amorphous crystalline mass near the umbilical cord possibly represents the recrystallized yolk sac. Another ptyctodont from the Gogo Formation, Austroptyctodus gardineri, also shows three small embryos inside it in the same position. Ptyctodontids have already provided the oldest definite evidence for vertebrate copulation, and the new specimens confirm that some placoderms had a remarkably advanced reproductive biology, comparable to that of some modern sharks and rays. The new discovery points to internal fertilization and viviparity in vertebrates as originating earliest within placoderms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Long, John A -- Trinajstic, Kate -- Young, Gavin C -- Senden, Tim -- England -- Nature. 2008 May 29;453(7195):650-2. doi: 10.1038/nature06966.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Museum Victoria, Melbourne, PO Box 666, Melbourne 3001, Australia. jlong@museum.vic.gov.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18509443" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Australia ; Biological Evolution ; Female ; Fishes/classification/*embryology/*physiology ; *Fossils ; History, Ancient ; Microscopy, Electron, Scanning ; Viviparity, Nonmammalian/*physiology
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    The development of allergic inflammation (2008)
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    Publication Date: 2008-07-25
    Description: Allergic disorders, such as anaphylaxis, hay fever, eczema and asthma, now afflict roughly 25% of people in the developed world. In allergic subjects, persistent or repetitive exposure to allergens, which typically are intrinsically innocuous substances common in the environment, results in chronic allergic inflammation. This in turn produces long-term changes in the structure of the affected organs and substantial abnormalities in their function. It is therefore important to understand the characteristics and consequences of acute and chronic allergic inflammation, and in particular to explore how mast cells can contribute to several features of this maladaptive pattern of immunological reactivity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573758/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573758/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galli, Stephen J -- Tsai, Mindy -- Piliponsky, Adrian M -- R01 AI023990/AI/NIAID NIH HHS/ -- R01 AI023990-20/AI/NIAID NIH HHS/ -- R01 AI070813/AI/NIAID NIH HHS/ -- R01 AI070813-01/AI/NIAID NIH HHS/ -- R01 CA072074/CA/NCI NIH HHS/ -- R01 CA072074-15/CA/NCI NIH HHS/ -- England -- Nature. 2008 Jul 24;454(7203):445-54. doi: 10.1038/nature07204.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA. sgalli@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18650915" target="_blank"〉PubMed〈/a〉
    Keywords: Allergens/immunology ; Animals ; Chronic Disease ; Epithelium/immunology ; Humans ; Hypersensitivity/genetics/*immunology/*pathology ; Immunoglobulin E/immunology ; Inflammation/genetics/*immunology/*pathology
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    Cell imaging: Light activated (2008)
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    Publication Date: 2008-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2008 Dec 11;456(7223):826-7. doi: 10.1038/456826a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19079062" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/physiology ; *Carrier Proteins/metabolism/radiation effects ; Cells/*cytology ; Halorhodopsins ; Ion Channels/physiology ; *Light ; Retinaldehyde/metabolism
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    Last chance to save one of world's most species-rich regions (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-10-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Christian, Max -- Finer, Matt -- Ross, Carl -- England -- Nature. 2008 Oct 16;455(7215):861. doi: 10.1038/455861c.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18923487" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Carbon Dioxide/analysis ; Conservation of Natural Resources/*economics/methods/*trends ; Ecuador ; Fuel Oils/*economics ; *Greenhouse Effect ; *International Cooperation
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    IRF4 addiction in multiple myeloma (2008)
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    Publication Date: 2008-06-24
    Description: The transcription factor IRF4 (interferon regulatory factor 4) is required during an immune response for lymphocyte activation and the generation of immunoglobulin-secreting plasma cells. Multiple myeloma, a malignancy of plasma cells, has a complex molecular aetiology with several subgroups defined by gene expression profiling and recurrent chromosomal translocations. Moreover, the malignant clone can sustain multiple oncogenic lesions, accumulating genetic damage as the disease progresses. Current therapies for myeloma can extend survival but are not curative. Hence, new therapeutic strategies are needed that target molecular pathways shared by all subtypes of myeloma. Here we show, using a loss-of-function, RNA-interference-based genetic screen, that IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism. Gene expression profiling and genome-wide chromatin immunoprecipitation analysis uncovered an extensive network of IRF4 target genes and identified MYC as a direct target of IRF4 in activated B cells and myeloma. Unexpectedly, IRF4 was itself a direct target of MYC transactivation, generating an autoregulatory circuit in myeloma cells. Although IRF4 is not genetically altered in most myelomas, they are nonetheless addicted to an aberrant IRF4 regulatory network that fuses the gene expression programmes of normal plasma cells and activated B cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542904/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542904/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shaffer, Arthur L -- Emre, N C Tolga -- Lamy, Laurence -- Ngo, Vu N -- Wright, George -- Xiao, Wenming -- Powell, John -- Dave, Sandeep -- Yu, Xin -- Zhao, Hong -- Zeng, Yuxin -- Chen, Bangzheng -- Epstein, Joshua -- Staudt, Louis M -- CA113992/CA/NCI NIH HHS/ -- CA97513/CA/NCI NIH HHS/ -- R01 CA113992/CA/NCI NIH HHS/ -- R01 CA113992-02/CA/NCI NIH HHS/ -- R33 CA097513-03/CA/NCI NIH HHS/ -- Z99 CA999999/Intramural NIH HHS/ -- England -- Nature. 2008 Jul 10;454(7201):226-31. doi: 10.1038/nature07064. Epub 2008 Jun 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18568025" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/metabolism/pathology ; Cell Survival ; Cell Transformation, Neoplastic/genetics ; Cells, Cultured ; Chromatin Immunoprecipitation ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genes, myc/genetics ; Humans ; Interferon Regulatory Factors/deficiency/genetics/*metabolism ; Mice ; Multiple Myeloma/genetics/*metabolism/*pathology ; Proto-Oncogene Proteins c-myc/metabolism ; RNA Interference ; Transcriptional Activation
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    Medical schools swap pigs for plastic (2008)
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    Publication Date: 2008-05-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wadman, Meredith -- England -- Nature. 2008 May 8;453(7192):140-1. doi: 10.1038/453140a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18464702" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Use Alternatives/statistics & numerical data/*trends ; Animals ; Computer Simulation/utilization ; General Surgery/*education ; Humans ; Manikins ; *Plastics ; *Schools, Medical/ethics ; *Swine/surgery ; User-Computer Interface
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    Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation (2008)
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    Publication Date: 2008-09-12
    Description: Cell growth and proliferation require coordinated ribosomal biogenesis and translation. Eukaryotic initiation factors (eIFs) control translation at the rate-limiting step of initiation. So far, only two eIFs connect extracellular stimuli to global translation rates: eIF4E acts in the eIF4F complex and regulates binding of capped messenger RNA to 40S subunits, downstream of growth factors, and eIF2 controls loading of the ternary complex on the 40S subunit and is inhibited on stress stimuli. No eIFs have been found to link extracellular stimuli to the activity of the large 60S ribosomal subunit. eIF6 binds 60S ribosomes precluding ribosome joining in vitro. However, studies in yeasts showed that eIF6 is required for ribosome biogenesis rather than translation. Here we show that mammalian eIF6 is required for efficient initiation of translation, in vivo. eIF6 null embryos are lethal at preimplantation. Heterozygous mice have 50% reduction of eIF6 levels in all tissues, and show reduced mass of hepatic and adipose tissues due to a lower number of cells and to impaired G1/S cell cycle progression. eIF6(+/-) cells retain sufficient nucleolar eIF6 and normal ribosome biogenesis. The liver of eIF6(+/-) mice displays an increase of 80S in polysomal profiles, indicating a defect in initiation of translation. Consistently, isolated hepatocytes have impaired insulin-stimulated translation. Heterozygous mouse embryonic fibroblasts recapitulate the organism phenotype and have normal ribosome biogenesis, reduced insulin-stimulated translation, and delayed G1/S phase progression. Furthermore, eIF6(+/-) cells are resistant to oncogene-induced transformation. Thus, eIF6 is the first eIF associated with the large 60S subunit that regulates translation in response to extracellular signals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753212/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753212/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gandin, Valentina -- Miluzio, Annarita -- Barbieri, Anna Maria -- Beugnet, Anne -- Kiyokawa, Hiroaki -- Marchisio, Pier Carlo -- Biffo, Stefano -- GGP05043/Telethon/Italy -- R01/PHS HHS/ -- R01 CA112282/CA/NCI NIH HHS/ -- R01 CA112282-04/CA/NCI NIH HHS/ -- England -- Nature. 2008 Oct 2;455(7213):684-8. doi: 10.1038/nature07267. Epub 2008 Sep 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18784653" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/cytology ; Animals ; Body Weight ; Cell Division/drug effects ; Cell Nucleolus/metabolism ; *Cell Transformation, Neoplastic ; Cells, Cultured ; Cytoplasm/metabolism ; Fibroblasts ; G1 Phase/drug effects ; Heterozygote ; Insulin/pharmacology ; Liver/cytology/growth & development ; Mice ; NIH 3T3 Cells ; Oncogenes/genetics ; *Peptide Chain Initiation, Translational/drug effects ; Peptide Initiation Factors/deficiency/genetics/*metabolism ; Ribosomes/chemistry/metabolism ; *S Phase/drug effects
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    The essential role of the CopN protein in Chlamydia pneumoniae intracellular growth (2008)
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    Publication Date: 2008-10-03
    Description: Bacterial virulence determinants can be identified, according to the molecular Koch's postulates, if inactivation of a gene associated with a suspected virulence trait results in a loss in pathogenicity. This approach is commonly used with genetically tractable organisms. However, the current lack of tools for targeted gene disruptions in obligate intracellular microbial pathogens seriously hampers the identification of their virulence factors. Here we demonstrate an approach to studying potential virulence factors of genetically intractable organisms, such as Chlamydia. Heterologous expression of Chlamydia pneumoniae CopN in yeast and mammalian cells resulted in a cell cycle arrest, presumably owing to alterations in the microtubule cytoskeleton. A screen of a small molecule library identified two compounds that alleviated CopN-induced growth inhibition in yeast. These compounds interfered with C. pneumoniae replication in mammalian cells, presumably by 'knocking out' CopN function, revealing an essential role of CopN in the support of C. pneumoniae growth during infection. This work demonstrates the role of a specific chlamydial protein in virulence. The chemical biology approach described here can be used to identify virulence factors, and the reverse chemical genetic strategy can result in the identification of lead compounds for the development of novel therapeutics.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673727/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673727/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, Jin -- Lesser, Cammie F -- Lory, Stephen -- R01 AI064285/AI/NIAID NIH HHS/ -- R01 AI064285-03/AI/NIAID NIH HHS/ -- England -- Nature. 2008 Nov 6;456(7218):112-5. doi: 10.1038/nature07355. Epub 2008 Oct 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Molecular Genetics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18830244" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Proteins/antagonists & inhibitors/genetics/*metabolism ; Cell Cycle ; Cell Line ; Chlamydophila pneumoniae/drug effects/genetics/*growth & ; development/*pathogenicity ; Gene Expression ; Genes, Essential ; Heterocyclic Compounds with 4 or More Rings/pharmacology ; Humans ; Intracellular Space/*microbiology ; Microtubules/metabolism ; Saccharomyces cerevisiae/cytology/drug effects/genetics/metabolism ; Virulence/drug effects ; Virulence Factors/antagonists & inhibitors/genetics/*metabolism
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    A global network for investigating the genomic epidemiology of malaria (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-12-17
    Description: Large-scale studies of genomic variation could assist efforts to eliminate malaria. But there are scientific, ethical and practical challenges to carrying out such studies in developing countries, where the burden of disease is greatest. The Malaria Genomic Epidemiology Network (MalariaGEN) is now working to overcome these obstacles, using a consortial approach that brings together researchers from 21 countries.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758999/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758999/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malaria Genomic Epidemiology Network -- 076934/Wellcome Trust/United Kingdom -- 077383/Wellcome Trust/United Kingdom -- 077383/Z/05/Z/Wellcome Trust/United Kingdom -- G0200454/Medical Research Council/United Kingdom -- G0200454(62635)/Medical Research Council/United Kingdom -- G0600230/Medical Research Council/United Kingdom -- G0600230(77610)/Medical Research Council/United Kingdom -- G0600718/Medical Research Council/United Kingdom -- G19/9/Medical Research Council/United Kingdom -- England -- Nature. 2008 Dec 11;456(7223):732-7. doi: 10.1038/nature07632.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The University of Buea, PO Box 63, Buea, South West Province, Cameroon.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19079050" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles/genetics ; Epidemiologic Research Design ; Genome, Human/*genetics ; Genome-Wide Association Study ; Global Health ; Humans ; Immunity, Innate/genetics ; Malaria/*epidemiology/*genetics ; Plasmodium/genetics ; Polymorphism, Single Nucleotide
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    Perceptual accuracy and conflicting effects of certainty on risk-taking behaviour (2008)
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    Publication Date: 2008-06-13
    Description: The 'certainty effect' is a notable violation of expected utility theory by decision makers. It shows that people's tendency to select the safer of two prospects increases when this prospect provides a good outcome with certainty (for example, people prefer a monetary gain of 3 with certainty over 4 with a probability of 0.8, but do not prefer 3 with a probability of 0.25 over 4 with a probability of 0.2). Subsequent work on experience-based decision making in rats extended the certainty effect to other animals, suggesting its generality across different species and different decision-making mechanisms. However, an attempt to replicate this study with human subjects showed a surprising 'reversed certainty effect', namely, the tendency to prefer the safer option decreases when this prospect is associated with certainty (and people now prefer 4 with a probability of 0.8 over 3 with certainty). Here we show that these conflicting results can be explained by perceptual noise and that the certainty effect can be restored experimentally by reducing perceptual accuracy. Using complementary experiments in humans and honeybees (Apis mellifera), we show that by manipulating perceptual accuracy in experience-based tasks, both the certainty and the reversed certainty effects can be exhibited by humans and other animals: the certainty effect emerges when it is difficult to discriminate between the different rewards, whereas the reversed certainty effect emerges when discrimination is easy. Our results fit a simple process-based model of matching behaviour, capable of explaining the certainty effect in humans and other animals that make repeated decisions based on experience. This mechanism should probably be distinguished from those involved in the original certainty effect that was exhibited by human subjects in single description-based problems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shafir, Sharoni -- Reich, Taly -- Tsur, Erez -- Erev, Ido -- Lotem, Arnon -- England -- Nature. 2008 Jun 12;453(7197):917-20. doi: 10.1038/nature06841.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉B. Triwaks Bee Research Center, Department of Entomology, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18548069" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bees/*physiology ; Choice Behavior/*physiology ; Humans ; Models, Psychological ; Photic Stimulation ; *Reward ; *Risk-Taking ; *Uncertainty
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    Cancer: hay in a haystack (2008)
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    Publication Date: 2008-01-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shannon, Kevin M -- Le Beau, Michelle M -- England -- Nature. 2008 Jan 17;451(7176):252-3. doi: 10.1038/451252a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18202630" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosomes, Human, Pair 5/*genetics ; Erythroid Cells/cytology/metabolism ; *Genes, Tumor Suppressor ; Genetic Predisposition to Disease/*genetics ; Humans ; *RNA Interference ; Ribosomal Proteins/deficiency/*genetics/metabolism ; Syndrome
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    Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice (2007)
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    Publication Date: 2007
    Description: Electrical microstimulation can establish causal links between the activity of groups of neurons and perceptual and cognitive functions. However, the number and identities of neurons microstimulated, as well as the number of action potentials evoked, are difficult to ascertain. To address these issues we introduced the light-gated algal channel channelrhodopsin-2 (ChR2) specifically into a small fraction of layer 2/3 neurons of the mouse primary somatosensory cortex. ChR2 photostimulation in vivo reliably generated stimulus-locked action potentials at frequencies up to 50 Hz. Here we show that naive mice readily learned to detect brief trains of action potentials (five light pulses, 1 ms, 20 Hz). After training, mice could detect a photostimulus firing a single action potential in approximately 300 neurons. Even fewer neurons (approximately 60) were required for longer stimuli (five action potentials, 250 ms). Our results show that perceptual decisions and learning can be driven by extremely brief epochs of cortical activity in a sparse subset of supragranular cortical pyramidal neurons.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425380/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425380/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huber, Daniel -- Petreanu, Leopoldo -- Ghitani, Nima -- Ranade, Sachin -- Hromadka, Tomas -- Mainen, Zach -- Svoboda, Karel -- Howard Hughes Medical Institute/ -- England -- Nature. 2008 Jan 3;451(7174):61-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia 20147, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18094685" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/physiology/radiation effects ; Algal Proteins/genetics/metabolism ; Animals ; Behavior, Animal/*physiology/*radiation effects ; Cerebral Cortex/cytology/*physiology/*radiation effects ; Electric Stimulation ; Learning/*physiology/radiation effects ; Mice ; Movement/*physiology ; Optics and Photonics ; Photic Stimulation ; Pyramidal Cells/metabolism/radiation effects ; Rhodopsins, Microbial/genetics/metabolism
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    Compartmentalized dendritic plasticity and input feature storage in neurons (2008)
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    Publication Date: 2008-03-28
    Description: Although information storage in the central nervous system is thought to be primarily mediated by various forms of synaptic plasticity, other mechanisms, such as modifications in membrane excitability, are available. Local dendritic spikes are nonlinear voltage events that are initiated within dendritic branches by spatially clustered and temporally synchronous synaptic input. That local spikes selectively respond only to appropriately correlated input allows them to function as input feature detectors and potentially as powerful information storage mechanisms. However, it is currently unknown whether any effective form of local dendritic spike plasticity exists. Here we show that the coupling between local dendritic spikes and the soma of rat hippocampal CA1 pyramidal neurons can be modified in a branch-specific manner through an N-methyl-d-aspartate receptor (NMDAR)-dependent regulation of dendritic Kv4.2 potassium channels. These data suggest that compartmentalized changes in branch excitability could store multiple complex features of synaptic input, such as their spatio-temporal correlation. We propose that this 'branch strength potentiation' represents a previously unknown form of information storage that is distinct from that produced by changes in synaptic efficacy both at the mechanistic level and in the type of information stored.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Losonczy, Attila -- Makara, Judit K -- Magee, Jeffrey C -- England -- Nature. 2008 Mar 27;452(7186):436-41. doi: 10.1038/nature06725.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Dr Ashburn, Virginia 20147, USA. losonczya@janelia.hhmi.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18368112" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/physiology ; Animals ; Cell Shape ; Dendrites/*physiology ; Ion Channel Gating ; Male ; Mice ; Models, Neurological ; Neuronal Plasticity/*physiology ; Pyramidal Cells/*cytology/*metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/metabolism ; Shal Potassium Channels/deficiency/genetics/metabolism
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    Using temperature to analyse temporal dynamics in the songbird motor pathway (2008)
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    Publication Date: 2008-11-14
    Description: Many complex behaviours, like speech or music, have a hierarchical organization with structure on many timescales, but it is not known how the brain controls the timing of behavioural sequences, or whether different circuits control different timescales of the behaviour. Here we address these issues by using temperature to manipulate the biophysical dynamics in different regions of the songbird forebrain involved in song production. We find that cooling the premotor nucleus HVC (formerly known as the high vocal centre) slows song speed across all timescales by up to 45 per cent but only slightly alters the acoustic structure, whereas cooling the downstream motor nucleus RA (robust nucleus of the arcopallium) has no observable effect on song timing. Our observations suggest that dynamics within HVC are involved in the control of song timing, perhaps through a chain-like organization. Local manipulation of brain temperature should be broadly applicable to the identification of neural circuitry that controls the timing of behavioural sequences and, more generally, to the study of the origin and role of oscillatory and other forms of brain dynamics in neural systems.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723166/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723166/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Long, Michael A -- Fee, Michale S -- DC009280/DC/NIDCD NIH HHS/ -- K99 DC009280/DC/NIDCD NIH HHS/ -- K99 DC009280-02/DC/NIDCD NIH HHS/ -- MH067105/MH/NIMH NIH HHS/ -- R01 MH067105/MH/NIMH NIH HHS/ -- R01 MH067105-04/MH/NIMH NIH HHS/ -- England -- Nature. 2008 Nov 13;456(7219):189-94. doi: 10.1038/nature07448.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19005546" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cold Temperature ; Efferent Pathways/physiology ; Finches/*physiology ; High Vocal Center/*physiology ; Neurons/physiology ; Prosencephalon/*physiology/radiography ; Time Factors ; Vocalization, Animal/*physiology
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    Pyruvate kinase M2 is a phosphotyrosine-binding protein (2008)
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    Publication Date: 2008-03-14
    Description: Growth factors stimulate cells to take up excess nutrients and to use them for anabolic processes. The biochemical mechanism by which this is accomplished is not fully understood but it is initiated by phosphorylation of signalling proteins on tyrosine residues. Using a novel proteomic screen for phosphotyrosine-binding proteins, we have made the observation that an enzyme involved in glycolysis, the human M2 (fetal) isoform of pyruvate kinase (PKM2), binds directly and selectively to tyrosine-phosphorylated peptides. We show that binding of phosphotyrosine peptides to PKM2 results in release of the allosteric activator fructose-1,6-bisphosphate, leading to inhibition of PKM2 enzymatic activity. We also provide evidence that this regulation of PKM2 by phosphotyrosine signalling diverts glucose metabolites from energy production to anabolic processes when cells are stimulated by certain growth factors. Collectively, our results indicate that expression of this phosphotyrosine-binding form of pyruvate kinase is critical for rapid growth in cancer cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Christofk, Heather R -- Vander Heiden, Matthew G -- Wu, Ning -- Asara, John M -- Cantley, Lewis C -- R01 GM056203/GM/NIGMS NIH HHS/ -- T32 CA009172/CA/NCI NIH HHS/ -- England -- Nature. 2008 Mar 13;452(7184):181-6. doi: 10.1038/nature06667.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Systems Biology.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18337815" target="_blank"〉PubMed〈/a〉
    Keywords: Allosteric Site ; Animals ; Catalysis ; Cell Line ; Cell Proliferation/drug effects ; Cells/drug effects/metabolism ; HeLa Cells ; Humans ; Lysine/metabolism ; Models, Molecular ; Peptide Library ; Phosphotyrosine/*metabolism ; Protein Binding ; Proteomics ; Pyruvate Kinase/antagonists & inhibitors/*metabolism ; Substrate Specificity
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    The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth (2008)
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    Publication Date: 2008-03-14
    Description: Many tumour cells have elevated rates of glucose uptake but reduced rates of oxidative phosphorylation. This persistence of high lactate production by tumours in the presence of oxygen, known as aerobic glycolysis, was first noted by Otto Warburg more than 75 yr ago. How tumour cells establish this altered metabolic phenotype and whether it is essential for tumorigenesis is as yet unknown. Here we show that a single switch in a splice isoform of the glycolytic enzyme pyruvate kinase is necessary for the shift in cellular metabolism to aerobic glycolysis and that this promotes tumorigenesis. Tumour cells have been shown to express exclusively the embryonic M2 isoform of pyruvate kinase. Here we use short hairpin RNA to knockdown pyruvate kinase M2 expression in human cancer cell lines and replace it with pyruvate kinase M1. Switching pyruvate kinase expression to the M1 (adult) isoform leads to reversal of the Warburg effect, as judged by reduced lactate production and increased oxygen consumption, and this correlates with a reduced ability to form tumours in nude mouse xenografts. These results demonstrate that M2 expression is necessary for aerobic glycolysis and that this metabolic phenotype provides a selective growth advantage for tumour cells in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Christofk, Heather R -- Vander Heiden, Matthew G -- Harris, Marian H -- Ramanathan, Arvind -- Gerszten, Robert E -- Wei, Ru -- Fleming, Mark D -- Schreiber, Stuart L -- Cantley, Lewis C -- R01 GM056203/GM/NIGMS NIH HHS/ -- T32 CA009172/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2008 Mar 13;452(7184):230-3. doi: 10.1038/nature06734.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18337823" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing/*genetics ; Animals ; Cell Line, Tumor ; Cell Proliferation ; Fructosediphosphates/metabolism ; Gene Expression Regulation, Neoplastic ; Glycolysis ; Humans ; Lactic Acid/metabolism ; Lung Neoplasms/genetics/metabolism/pathology ; Male ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Neoplasms/enzymology/genetics/*metabolism/*pathology ; Oxidative Phosphorylation ; Oxygen Consumption ; Pyruvate Kinase/*genetics/*metabolism ; Pyruvic Acid/metabolism
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    Free choice activates a decision circuit between frontal and parietal cortex (2008)
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    Publication Date: 2008-04-18
    Description: We often face alternatives that we are free to choose between. Planning movements to select an alternative involves several areas in frontal and parietal cortex that are anatomically connected into long-range circuits. These areas must coordinate their activity to select a common movement goal, but how neural circuits make decisions remains poorly understood. Here we simultaneously record from the dorsal premotor area (PMd) in frontal cortex and the parietal reach region (PRR) in parietal cortex to investigate neural circuit mechanisms for decision making. We find that correlations in spike and local field potential (LFP) activity between these areas are greater when monkeys are freely making choices than when they are following instructions. We propose that a decision circuit featuring a sub-population of cells in frontal and parietal cortex may exchange information to coordinate activity between these areas. Cells participating in this decision circuit may influence movement choices by providing a common bias to the selection of movement goals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728060/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728060/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pesaran, Bijan -- Nelson, Matthew J -- Andersen, Richard A -- R01 EY007492/EY/NEI NIH HHS/ -- R01 EY007492-19/EY/NEI NIH HHS/ -- England -- Nature. 2008 May 15;453(7193):406-9. doi: 10.1038/nature06849. Epub 2008 Apr 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Neural Science, New York University, New York, New York 10003, USA. bijan@nyu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18418380" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/physiology ; Animals ; Choice Behavior/*physiology ; Fixation, Ocular/physiology ; Frontal Lobe/*physiology ; Macaca mulatta/*physiology ; Male ; Neural Pathways/*physiology ; Neurons/metabolism ; Parietal Lobe/*physiology ; Photic Stimulation ; Probability ; ROC Curve ; Reward ; Saccades/physiology
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    AIDS: prehistory of HIV-1 (2008)
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    Publication Date: 2008-10-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sharp, Paul M -- Hahn, Beatrice H -- England -- Nature. 2008 Oct 2;455(7213):605-6. doi: 10.1038/455605a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18833267" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Democratic Republic of the Congo/epidemiology ; *Evolution, Molecular ; Genetic Variation/*genetics ; HIV Infections/*epidemiology/*virology ; HIV-1/classification/*genetics/*isolation & purification ; History, 20th Century ; Humans ; Phylogeny
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    Cancer: An unexpected addiction (2008)
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    Publication Date: 2008-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shaughnessy, John D -- England -- Nature. 2008 Jul 10;454(7201):172-3. doi: 10.1038/454172a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18615074" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/metabolism/pathology ; Cell Survival ; Cell Transformation, Neoplastic/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/genetics ; Genes, myc/genetics ; Health ; Humans ; Interferon Regulatory Factors/deficiency/genetics/*metabolism ; Multiple Myeloma/genetics/*metabolism/*pathology ; Proto-Oncogene Proteins c-myc/metabolism
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    T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance (2008)
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    Publication Date: 2008-08-15
    Description: Furin is one of seven proprotein convertase family members that promote proteolytic maturation of proproteins. It is induced in activated T cells and is reported to process a variety of substrates including the anti-inflammatory cytokine transforming growth factor (TGF)-beta1 (refs 2-4), but the non-redundant functions of furin versus other proprotein convertases in T cells are unclear. Here we show that conditional deletion of furin in T cells allowed for normal T-cell development but impaired the function of regulatory and effector T cells, which produced less TGF-beta1. Furin-deficient T regulatory (Treg) cells were less protective in a T-cell transfer colitis model and failed to induce Foxp3 in normal T cells. Additionally, furin-deficient effector cells were inherently over-active and were resistant to suppressive activity of wild-type Treg cells. Thus, our results indicate that furin is indispensable in maintaining peripheral tolerance, which is due, at least in part, to its non-redundant, essential function in regulating TGF-beta1 production. Targeting furin has emerged as a strategy in malignant and infectious disease. Our results suggest that inhibiting furin might activate immune responses, but may result in a breakdown in peripheral tolerance.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758057/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758057/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pesu, Marko -- Watford, Wendy T -- Wei, Lai -- Xu, Lili -- Fuss, Ivan -- Strober, Warren -- Andersson, John -- Shevach, Ethan M -- Quezado, Martha -- Bouladoux, Nicolas -- Roebroek, Anton -- Belkaid, Yasmine -- Creemers, John -- O'Shea, John J -- Z99 EY999999/Intramural NIH HHS/ -- England -- Nature. 2008 Sep 11;455(7210):246-50. doi: 10.1038/nature07210.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Immunology and Inflammation Branch, National Institute for Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. pesum@mail.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18701887" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD/immunology ; Antigens, CD4/immunology/metabolism ; Autoimmunity/immunology ; Colitis/immunology ; Furin/deficiency/genetics/*metabolism ; Gene Expression Profiling ; Immune Tolerance/*immunology ; Immunologic Memory/immunology ; Integrin alpha Chains/immunology ; Lymphocyte Activation/immunology ; Mice ; Mice, Inbred C57BL ; T-Lymphocytes/cytology/*enzymology/*immunology ; Thymus Gland/cytology/immunology ; Transforming Growth Factor beta1/biosynthesis/genetics/immunology
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    Ultrasonic frogs show hyperacute phonotaxis to female courtship calls (2008)
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    Publication Date: 2008-05-13
    Description: Sound communication plays a vital role in frog reproduction, in which vocal advertisement is generally the domain of males. Females are typically silent, but in a few anuran species they can produce a feeble reciprocal call or rapping sounds during courtship. Males of concave-eared torrent frogs (Odorrana tormota) have demonstrated ultrasonic communication capacity. Although females of O. tormota have an unusually well-developed vocal production system, it is unclear whether or not they produce calls or are only passive partners in a communication system dominated by males. Here we show that before ovulation, gravid females of O. tormota emit calls that are distinct from males' advertisement calls, having higher fundamental frequencies and harmonics and shorter call duration. In the field and in a quiet, darkened indoor arena, these female calls evoke vocalizations and extraordinarily precise positive phonotaxis (a localization error of 〈1 degrees ), rivalling that of vertebrates with the highest localization acuity (barn owls, dolphins, elephants and humans). The localization accuracy of O. tormota is remarkable in light of their small head size (interaural distance of 〈1 cm), and suggests an additional selective advantage of high-frequency hearing beyond the ability to avoid masking by low-frequency background noise.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, Jun-Xian -- Feng, Albert S -- Xu, Zhi-Min -- Yu, Zu-Lin -- Arch, Victoria S -- Yu, Xin-Jian -- Narins, Peter M -- England -- Nature. 2008 Jun 12;453(7197):914-6. doi: 10.1038/nature06719. Epub 2008 May 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. shenjx@sun5.ibp.ac.cn〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18469804" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; China ; *Courtship ; Female ; Humans ; Male ; Motor Activity/*physiology ; Ranidae/*physiology ; *Sex Characteristics ; Sound ; *Ultrasonics ; Vocalization, Animal/*physiology
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    Pleiotropic scaling of gene effects and the 'cost of complexity' (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-03-28
    Description: As perceived by Darwin, evolutionary adaptation by the processes of mutation and selection is difficult to understand for complex features that are the product of numerous traits acting in concert, for example the eye or the apparatus of flight. Typically, mutations simultaneously affect multiple phenotypic characters. This phenomenon is known as pleiotropy. The impact of pleiotropy on evolution has for decades been the subject of formal analysis. Some authors have suggested that pleiotropy can impede evolutionary progress (a so-called 'cost of complexity'). The plausibility of various phenomena attributed to pleiotropy depends on how many traits are affected by each mutation and on our understanding of the correlation between the number of traits affected by each gene substitution and the size of mutational effects on individual traits. Here we show, by studying pleiotropy in mice with the use of quantitative trait loci (QTLs) affecting skeletal characters, that most QTLs affect a relatively small subset of traits and that a substitution at a QTL has an effect on each trait that increases with the total number of traits affected. This suggests that evolution of higher organisms does not suffer a 'cost of complexity' because most mutations affect few traits and the size of the effects does not decrease with pleiotropy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wagner, Gunter P -- Kenney-Hunt, Jane P -- Pavlicev, Mihaela -- Peck, Joel R -- Waxman, David -- Cheverud, James M -- England -- Nature. 2008 Mar 27;452(7186):470-2. doi: 10.1038/nature06756.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520-8106, USA. gunter.wagner@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18368117" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Body Size/*genetics ; Body Weight/genetics ; Crosses, Genetic ; Female ; Male ; Mice ; Mice, Inbred Strains ; *Models, Genetic ; Mutation/*genetics ; Phenotype ; Quantitative Trait Loci/*genetics ; Selection, Genetic ; *Skeleton
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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    Cellular memory hints at the origins of intelligence (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-01-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ball, Philip -- England -- Nature. 2008 Jan 24;451(7177):385. doi: 10.1038/451385a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18216817" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*physiology ; Biological Clocks/physiology ; Electric Stimulation ; *Environment ; Humans ; Intelligence ; Memory/*physiology ; Physarum/cytology/*physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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    Lab disinfectant harms mouse fertility. Patricia Hunt interviewed by Brendan Maher (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-06-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hunt, Patricia -- England -- Nature. 2008 Jun 19;453(7198):964. doi: 10.1038/453964a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18563110" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Laboratory/abnormalities ; Benzalkonium Compounds/*toxicity ; Benzhydryl Compounds ; Disinfectants/chemistry/*toxicity ; Environmental Exposure ; Female ; Fertility/*drug effects ; Fetal Death/chemically induced ; *Housing, Animal ; *Laboratories ; Male ; Mice ; Phenols ; Pregnancy ; Quaternary Ammonium Compounds/*toxicity
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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    Genetics: The production line (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-08-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petherick, Anna -- England -- Nature. 2008 Aug 28;454(7208):1042-5. doi: 10.1038/4541042a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18756228" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gene Expression Profiling ; Gene Expression Regulation/genetics ; Genome/*genetics ; Humans ; Mice ; *Models, Genetic ; Oligonucleotide Array Sequence Analysis ; RNA, Untranslated/*biosynthesis/genetics/*metabolism ; *Transcription, Genetic ; Yeasts/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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    An intrinsic mechanism of corticogenesis from embryonic stem cells (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-08-22
    Description: The cerebral cortex develops through the coordinated generation of dozens of neuronal subtypes, but the mechanisms involved remain unclear. Here we show that mouse embryonic stem cells, cultured without any morphogen but in the presence of a sonic hedgehog inhibitor, recapitulate in vitro the major milestones of cortical development, leading to the sequential generation of a diverse repertoire of neurons that display most salient features of genuine cortical pyramidal neurons. When grafted into the cerebral cortex, these neurons develop patterns of axonal projections corresponding to a wide range of cortical layers, but also to highly specific cortical areas, in particular visual and limbic areas, thereby demonstrating that the identity of a cortical area can be specified without any influence from the brain. The discovery of intrinsic corticogenesis sheds new light on the mechanisms of neuronal specification, and opens new avenues for the modelling and treatment of brain diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gaspard, Nicolas -- Bouschet, Tristan -- Hourez, Raphael -- Dimidschstein, Jordane -- Naeije, Gilles -- van den Ameele, Jelle -- Espuny-Camacho, Ira -- Herpoel, Adele -- Passante, Lara -- Schiffmann, Serge N -- Gaillard, Afsaneh -- Vanderhaeghen, Pierre -- England -- Nature. 2008 Sep 18;455(7211):351-7. doi: 10.1038/nature07287. Epub 2008 Aug 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IRIBHM (Institute for Interdisciplinary Research), Universite Libre de Bruxelles (ULB).〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18716623" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/drug effects/physiology ; *Cell Differentiation/drug effects ; Cell Lineage/drug effects ; Cerebral Cortex/*cytology/drug effects/*embryology ; Embryonic Stem Cells/*cytology/drug effects ; Mice ; Pyramidal Cells/drug effects ; Veratrum Alkaloids/pharmacology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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    BAX activation is initiated at a novel interaction site (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-10-25
    Description: BAX is a pro-apoptotic protein of the BCL-2 family that is stationed in the cytosol until activated by a diversity of stress stimuli to induce cell death. Anti-apoptotic proteins such as BCL-2 counteract BAX-mediated cell death. Although an interaction site that confers survival functionality has been defined for anti-apoptotic proteins, an activation site has not been identified for BAX, rendering its explicit trigger mechanism unknown. We previously developed stabilized alpha-helix of BCL-2 domains (SAHBs) that directly initiate BAX-mediated mitochondrial apoptosis. Here we demonstrate by NMR analysis that BIM SAHB binds BAX at an interaction site that is distinct from the canonical binding groove characterized for anti-apoptotic proteins. The specificity of the human BIM-SAHB-BAX interaction is highlighted by point mutagenesis that disrupts functional activity, confirming that BAX activation is initiated at this novel structural location. Thus, we have now defined a BAX interaction site for direct activation, establishing a new target for therapeutic modulation of apoptosis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597110/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597110/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gavathiotis, Evripidis -- Suzuki, Motoshi -- Davis, Marguerite L -- Pitter, Kenneth -- Bird, Gregory H -- Katz, Samuel G -- Tu, Ho-Chou -- Kim, Hyungjin -- Cheng, Emily H-Y -- Tjandra, Nico -- Walensky, Loren D -- 5P01CA92625/CA/NCI NIH HHS/ -- 5R01CA125562/CA/NCI NIH HHS/ -- 5R01CA50239/CA/NCI NIH HHS/ -- K99 HL095929/HL/NHLBI NIH HHS/ -- K99 HL095929-01A1/HL/NHLBI NIH HHS/ -- K99 HL095929-02/HL/NHLBI NIH HHS/ -- R00 HL095929/HL/NHLBI NIH HHS/ -- R01 CA050239/CA/NCI NIH HHS/ -- R01 CA125562/CA/NCI NIH HHS/ -- R01 CA125562-02/CA/NCI NIH HHS/ -- Intramural NIH HHS/ -- England -- Nature. 2008 Oct 23;455(7216):1076-81. doi: 10.1038/nature07396.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatric Oncology and the Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18948948" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Apoptosis ; Apoptosis Regulatory Proteins/chemistry/metabolism ; BH3 Interacting Domain Death Agonist Protein/metabolism ; Cell Line ; *Gene Expression Regulation ; Humans ; Membrane Proteins/chemistry/metabolism ; Mice ; Mutagenesis, Site-Directed ; Mutation/genetics ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Proto-Oncogene Proteins/chemistry/metabolism ; Sequence Alignment ; bcl-2-Associated X Protein/chemistry/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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