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  • 1
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    Exon Publications | Wilms Tumor
    Publication Date: 2024-05-24
    Description: The most important prognostic factors for Wilms tumor (WT) patients seem to be stage, histological subtype, and 1p/16q loss of heterozygosity (LOH) in chemotherapy-naive WTs. Over the last decade, age at diagnosis also was suggested to be an important risk factor for WT recurrence in Children’s Oncology Group (COG), United Kingdom (UK), and International Society of Pediatric Oncology (SIOP) studies. Several studies have analyzed age as a prognostic factor; these studies revealed age 〈2 years as a favorable prognostic factor, while age 〉4 years has been described as an adverse prognostic factor. In adults (〉18 years of age), WT represents less than 1% of all diagnosed renal tumors; therefore, diagnosis of WT in adults is often unexpected and poorly recognized, thereby inducing treatment delay with subsequent adverse outcome. One explanation for the higher risk of recurrence with increasing patient age is the higher frequency of anaplasia at higher age. Other suggested reasons are delay in diagnosis, advanced tumor stage at presentation, and intrinsically different biological behaviors. Whether age is really an independent risk factor, and whether age is a stronger prognostic factor than stage, histology, and LOH 1p/16q, needs to be further explored. This may provide some insight into whether older patients need to be treated more intensively, as is already advised for adult WT patients.
    Description: Published
    Keywords: MJR
    Language: English
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  • 2
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    Exon Publications | Wilms Tumor
    Publication Date: 2024-05-24
    Description: Wilms’ tumour (WT) is the most common paediatric renal tumour, which can present as a single nodule, as multifocal unilateral lesions or as bilateral tumours. Typically, WT comprises three histological components namely blastemal, epithelial and stromal. The proportion and the degree of maturation of these components vary significantly, making the histological appearance of each tumour unique. Classical triphasic WT rarely presents diagnostic difficulty for pathologists, but when only one component is present, especially in a small biopsy specimen, the differential diagnosis may include renal cell carcinoma, metanephric adenoma and hyperplastic nephrogenic rest for epithelial elements and clear cell sarcoma of the kidney, mesoblastic nephroma and synovial sarcoma for stromal elements. Pure blastemal-type WT may be difficult to distinguish from other embryonal ‘small round blue cell tumours’, including neuroblastoma, primitive neuroectodermal tumour/Ewing sarcoma, desmoplastic small round cell tumour and lymphoma. All the three components, though usually blastema, can become anaplastic, leading to the diagnosis of either focal or diffuse anaplasia. WT with diffuse anaplasia and WT with blastemal predominance (after preoperative che¬motherapy) are regarded as high-risk tumours and require more aggressive treatment. Careful assessment of the tumour and the normal kidney is critical for accurate subtyping and staging of WT, which is the basis for post-operative treatment. In addition, the identification and correct interpretation of nephrogenic rests may affect prognosis and management. Histological distinction between WT and nephrogenic rest is not always possible based on morphology alone, and implementation of new molecular genetic tools may aid in this regard. Other molecular genetic signatures of WT, such as P53 mutation and MYCN dysregulation, may provide future additional prognostic and therapeutic information.
    Description: Published
    Keywords: nephrogenic rest ; Wilms’ tumour ; MJR
    Language: English
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  • 3
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    Instituto de Investigaciones Marinas y Costeras "José Benito Vives de Andréis" | Santa Marta, Colombia
    Publication Date: 2024-05-24
    Description: En el inhóspito, Agreste y poco conocido Pacífico colombiano, se destaca un lugar especial por haberse constituido en el transcurso de las últimas dos décadas en epicentro de la investigación en biodiversidad marina: Isla Gorgona. Su condición insular y de Parque Nacional Natural hacen de ella, aunque poco accesible, un escenario ideal para la observación contemplativa y minuciosa de las muchas expresiones que la naturaleza ha sabido reunir allí, tanto en tierra como en las aguas que la circundan. Es lugar de paso obligado para grandes cetáceos y aves migratorias, posee formaciones coralinas que albergan una característica diversidad de peces e invertebrados, además de playas, acantilados, fondos de arena de roca que propician la coexistencia de variadas y contrastantes comunidades bióticas que han cautivado la atención de biólogos y estudiantes, lo que le ha valido el calificativo de "isla ciencia". Este libro da a conocer sus atributos naturales.
    Description: Published
    Description: Refereed
    Keywords: Peces marinos ; ASFA_2015::C::Coral reefs ; ASFA_2015::CComunidades coralinas ; ASFA_2015::AArrecifes coralinos ; ASFA_2015::E::Ecology
    Repository Name: AquaDocs
    Type: Book/Monograph/Conference Proceedings
    Format: 160pp.
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  • 4
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    Université de Carthage. Faculté des Sciences de Bizerte. Laboratoire de Biosurveillance de l’Environnement
    Publication Date: 2024-05-24
    Description: Le présent travail porte sur l’étude systématique et écologique du benthos dans les principaux étages bathymétriques du golfe de Tunis par le biais de plusieurs approches, dans le but d’établir l’état écologique du milieu. Il s’agit des paramètres de biodiversité, des faciès bionomiques, des interactions biotiques et abiotiques et des indices biotiques basés sur les groupes trophiques et les groupes écologiques. Cette étude a permis dans un premier temps d’enrichir la liste des invertébrés benthiques inventoriés dans le golfe de Tunis. Il s’agit de 4 espèces de Bryozoaires nouvelles pour la science (Trematooecia ligulata Ayari et Taylor, 2008, Herentia baptooecium sp. nov., Herentia orthosa sp. nov. et Cellepora sinusa sp. nov) et de 70 espèces nouvelles pour la Tunisie dont 24 Polychètes, 24 Bryozoaires, 7 Cnidaires et 5 Amphipodes. De plus, la description des faciès bionomiques a permis de préciser les limites des étages, mais également de tirer des renseignements scientifiques intéressants. Ainsi, au centre du golfe, l’étage bathyal supérieur commence à -120 m, après une légère déclivité du plateau continental à environ -100 m. La zone qui s’étend du nord de Ras El Fartas vers le large en passant par l’ouest de l’île de Zembra, est occupée par un herbier de Posidonies à -21 m et suivie d’un détritique côtier caractérisant la limite supérieure du circalittoral puis d’un détritique du large dont les caractéristiques témoignent de la régression du circalittoral. Au niveau de la troisième zone et en face de Sidi Daoued et de Ras El Ahmar, l’herbier de Posidonies se situe entre -22 et -38 m de profondeur. Ensuite, des faciès de sédiments meubles et de maërl en bon état se succèdent. A environ -67 m de profondeur, apparaît le rebord du plateau continental, suivi à -130 m, par l’étage bathyal supérieur vaseux. Au niveau de la quatrième zone, en face de Ras Gammarth, des tâches de Posidonies et de Cymodocées sont suivies d’un détritique côtier à -79 m, puis de la déclivité du plateau continental marquant le passage du circalittoral inférieur à l’étage bathyal supérieur caractérisé jusqu’ à -137 m par une vase appauvrie. Au niveau de la zone ouest, nous enregistrons un envasement en face de la lagune de Ghar El Melh et un faciès de maërl en face de Sidi Ali El Mekki. L’étude de la distribution des Polychètes en fonction des paramètres environnementaux considérés a permis quant à elle de déterminer les préférendums écologiques des espèces principales. Elle a montré, entre autres, que les Polychètes ne sont pas distribués dans le golfe de Tunis en fonction d’un seul gradient abiotique et que la profondeur joue ici un rôle primordial. L’approche écologique a été basée sur l’utilisation de plusieurs indices biotiques, et les résultats obtenus montrent que l’indice BENTIX est le plus fiable pour le cas du golfe de Tunis. L’utilisation conjointe des principaux indices a montré que l’état écologique est satisfaisant au large de Sidi Ali El Mekki, en face de Cap Farina, autour de l’île de Zembra, au nord du Cap Bon et en face de Ras El Ahmar et que le reste de la zone est en légère perturbation ou en changement vers un état de déséquilibre
    Description: This present work is about a systematic and an ecological study of the benthos within the main bathymetric levels of Tunis gulf using many approaches with aims to establish its ecological state. These are the biodiversity parameters, the bionomic features, biotic and abiotic interactions and the biotic indices based on the trophic groups and the ecological groups. Thanks to this present study, the species list of the macrobenthic invertebrates increases. Altogether 4 species of Bryozoa are newly described (Trematooecia ligulata Ayari et Taylor, 2008, Herentia baptooecium sp. nov., Herentia orthosa sp. nov. et Cellepora sinusa sp. nov) and 70 species are found here for the first time in Tunisia coast: 24 Polychaeta, 24 Bryozoans, 7 Cnidaria and 5 Amphipoda. In addition, description of the bionomic features, allowed to limit the bathymetric levels and also, provided much essential scientific informations. Thus, in the middle of the gulf, the upper bathyal level begins from -120 m after a slight declivity of the continental plateau at about -100 m. The area which extends from the northern of Ras Fartas to the offshore going by the west of Zembra Island is occupied by Posidonia meadows at -21 m and followed by a coastal detritic which characterizes the upper limit of the Circalittoral, after that an offshore detritic characterize the regression of the Circalittoral. At the third sector and in front of Sidi Daoued and Ras El Ahmar, The Posidonia meadows begin from -22 to -38 m. After that, soft bottoms and maerl in good state follow each other. The plateau continental edge is at about -67 m, and then the muddy Superior Bathyal comes at -130 m. Within the fourth area in front of Ras Gammarth, some Posidonia and Cymodocea are followed by a costal detritic at -79 m then by the continental plateau declivity witch indicates passing from Inferior Circalittoral to the Superior Bathyal characterized until -137 m by an impoverished muddy bottom. The west sector is characterized by a muddy bottom in front of the Ghar El Melh Lagoon and a maerl in front of Sidi Ali El Mekki. Study of Polychaeta distribution according to considered environmental parameters allowed us to establish the ecological preferendum of some principal species. It shows that Polychaeta were not distributed within Tunis Gulf according to only one abiotic gradient however the depth is a primordial factor. The ecological approach is based on the use of many biotic index, results obtained showed that the BENTIX index is the most adequate in the case of the Gulf of Tunis. According to the different index used simultaneously the ecological state is satisfactory offshore Sidi Ali El Mekki, in front of Cap Farina, around Zembra isle, at the north of Cap Bon, in front of Ras El Ahmar and that the rest of the area is slightly perturbed or on change toward an imbalance state.
    Description: PhD
    Keywords: macro-phytobenthos ; macro-zoobenthos ; Bryozoaires ; Polychètes ; systématique ; bionomie ; facteurs abiotiques ; indices biotiques ; état écologique
    Repository Name: AquaDocs
    Type: Thesis/Dissertation
    Format: 429 pp.
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  • 5
    Publication Date: 2024-05-24
    Description: Marine waste, including aquatic by-products, poses a significant environmental challenge and garners increasing attention for its potential valorization. The development of cost-effective, environmentally friendly, and circular technologies for transforming marine biomass into value-added products is crucial for the successful implementation of sustainable aquatic industries. This involves focusing on strategies that simultaneously reduce waste and energy demand. This document presents the research andbiotechnological innovations carried out under the ARIBiotech project, which aims to create new biological products from marine waste. In a circular economy perspective, this initiative seeks to turn sources of pollution into sustainable opportunities, contributing to the preservation of marine ecosystems while fostering innovative solutions. Exploiting marine biomass and valorizing sea by-products, whether by using them directly or extracting biopolymers, appears to be a promising solution for a more sustainable use of marine resources, leading to increased economic benefits. However, the realization of such developments is hindered by the lack of appropriate regulatory frameworks to enable the use of waste and by-products, ensuring product safety, quality, and acceptability. This white paper showcases a diverse range of bioproducts (Crab waste hydrolyzate, chitin, chitosan, collagen, gelatin, cellulose aerogels, shell powder, and bioactive extracts) derived from the application of biotechnologies on various marine waste and co-products,highlighting their potential to support sustainable development. This document aims to encourage policymakers to support the creation of alliances and innovations in blue biotechnology and enable the general public to benefit from advances in creating bioproducts from marine waste.
    Description: Published
    Description: Refereed
    Keywords: Marine waste ; Bioproducts ; Biotechnological innovations ; Circular economy ; Sustainable development ; Bio-technologie bleue ; Valorisation déchets marins
    Repository Name: AquaDocs
    Type: Book/Monograph/Conference Proceedings
    Format: 26 pp.
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  • 6
    Publication Date: 2024-05-24
    Description: In the marine realm, microorganisms are responsible for the bulk of primary production, thereby sustaining marine life across all trophic levels. Longhurst provinces have distinct microbial fingerprints; however, little is known about how microbial diversity and primary productivity change at finer spatial scales. Here, we sampled the Atlantic Ocean from south to north (~50°S–50°N), every ~0.5° latitude. We conducted measurements of primary productivity, chlorophyll-a and relative abundance of 16S and 18S rRNA genes, alongside analyses of the physicochemical and hydrographic environment. We analysed the diversity of autotrophs, mixotrophs and heterotrophs, and noted distinct patterns among these guilds across provinces with high and low chlorophyll-a conditions. Eukaryotic autotrophs and prokaryotic heterotrophs showed a shared inter-province diversity pattern, distinct from the diversity pattern shared by mixotrophs, cyanobacteria and eukaryotic heterotrophs. Additionally, we calculated samplewise productivity-specific length scales, the potential horizontal displacement of microbial communities by surface currents to an intrinsic biological rate (here, specific primary productivity). This scale provides key context for our trophically disaggregated diversity analysis that we could relate to underlying oceanographic features. We integrate this element to provide more nuanced insights into the mosaic-like nature of microbial provincialism, linking diversity patterns to oceanographic transport through primary production.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
    Format: application/pdf
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  • 7
    Publication Date: 2024-05-24
    Description: This paper demonstrates how historical research is a valuable tool for identifying past geological, geomorphological and climatic hazards and therefore critical for mitigating and reducing future risk. The authors describe the potential of a scientific field that straddles that of the geologist, geographer, historian and archivist. Historical records include a range of materials and sources of information, which can be very diverse; from written documents to cartographies, and from drawings to marble tombstones. They are all useful and convey important data, on the date of the event, the size of the phenomena, sometimes on ground effects, damage or magnitude. The authors discuss how to conduct historical research by providing a list of locations and how important historical documents can be found. Works that mention geological phenomena are listed, starting with the first occasional descriptions by individuals in letters, up to very specific publications in individual fields of interest. With this introduction, the editors of the Special Issue wish to draw attention to the importance of historical documentation, which is too often ignored or considered of low priority by the scientific community, but can contain key information on events, their impacts and social and cultural adaptations.
    Description: Published
    Description: 1777
    Description: JCR Journal
    Keywords: geological and geo-hydrological processes ; historical research; old documents ; land-use planning ; natursal hazard ; risk mitigation ; Europe
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 8
    Publication Date: 2024-05-24
    Description: A new subgenus Peculiaripalpus subgen. nov. with a new species Partnunia (Peculiaripalpus) longlingensis sp. nov. which belongs to Partnunia Piersig, 1896 is described and illustrated. Partnunia represents a newly record genus of Protziinae Koenike, 1909 for Chinese fauna. The diagnosis of Partnunia is modified according to the new species. An updated key is provided for the subfamilies, genera and subgenera of Hydryphantidae.
    Keywords: water mites; new taxa; scanning electron microscope
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
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  • 9
    Publication Date: 2024-05-24
    Description: Although Pliocene temperature and pCO2 are similar to those predicted in the IPPC RCP4.5 scenario, the distribution of coral reefs in the center of maximum coral diversity, the Coral Triangle, during this period has not been explored. We discovered a significantly lower occurrence of reefs during the Pliocene, which we refer to as the Pliocene Reef Gap, but this decrease was not associated with a drop in coral genus richness. While some of the multiple local causes that drove this decline, such as sea level rise, are analogs to drivers of Anthropocene reef decline, neither warming nor increasing pCO2 are among them.
    Keywords: Pliocene · Neogene · Coral triangle · ; Paleontology · Anthropocene · Coral reef decline
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
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  • 10
    Publication Date: 2024-05-24
    Description: A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC50 value of 0.74 μM.
    Keywords: aurantosides ; Siliquariaspongia japonica ; marine sponge ; nuclear magnetic resonance ; mass ; spectrometry ; anti-leishmanial activity ; marine natural products
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
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