Publication Date:
2019
Description:
〈p〉Publication date: 13 June 2019〈/p〉
〈p〉〈b〉Source:〈/b〉 Tetrahedron Letters, Volume 60, Issue 24〈/p〉
〈p〉Author(s): Wei-Mao Zhong, Jun-Feng Wang, Xiao-Yi Wei, Qi Zeng, Xia-Yu Chen, Yao Xiang, Xin-Peng Tian, Si Zhang, Li-Juan Long, Fa-Zuo Wang〈/p〉
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〈h5〉Abstract〈/h5〉
〈div〉〈p〉(±)-Eurotone A [(±)-〈strong〉1〈/strong〉], a pair of new enantiomeric polyketide dimers, as well as six known biogenetically related polyketides (〈strong〉2〈/strong〉–〈strong〉7〈/strong〉) were isolated from a marine-derived fungus 〈em〉Eurotium〈/em〉 sp. SCSIO F452. Their structures were determined by comprehensive spectroscopic methods, X-ray diffraction and quantum chemical calculations. Compound 〈strong〉1〈/strong〉 represented the first pair of spirodihydrobenzanthracene enantiomers isolated from marine fungi with their absolute configurations assigned. A plausible biosynthetic pathway involving a key acid-mediated dimerization was proposed for 〈strong〉1〈/strong〉. The antioxidative activities of the new enantiomers were evaluated.〈/p〉〈/div〉
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〈div xml:lang="en"〉
〈h5〉Graphical abstract〈/h5〉
〈div〉〈p〉〈figure〉〈img src="https://ars.els-cdn.com/content/image/1-s2.0-S0040403919304629-ga1.jpg" width="500" alt="Graphical abstract for this article" title=""〉〈/figure〉〈/p〉〈/div〉
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Print ISSN:
0040-4039
Electronic ISSN:
1873-3581
Topics:
Chemistry and Pharmacology
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