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  • hypertension  (146)
  • Springer  (146)
  • MDPI Publishing
  • 2020-2022
  • 1985-1989  (146)
Collection
Keywords
Publisher
  • Springer  (146)
  • MDPI Publishing
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Kinins in cerebrospinal fluid: Reduced concentration in spontaneously hypertensive rats (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 1238-1239 
    Details
    ISSN: 1420-9071
    Keywords: Kinins ; bradykinin ; kallidin ; cerebrospinal fluid ; HPLC ; hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Rat cerebrospinal fluid contains peptides which displace radiolabeled bradykinin from its specific antibodies. Two peptides which showed the same retention time as kallidin and bradykinin in a reverse phase high pressure liquid chromatography system were detected in cerebrospinal fluid of rats. The concentration of radioimmunologically detected kinins in the cerebrospinal fluid of spontaneously hypertensive rats of the Okamoto strain was lower than that of the Wistar Kyoto control rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946402
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  • 2
    Electronic Resource
    Electronic Resource
    Development of high blood pressure in spontaneously hypertensive rats is delayed by treatment with cyclosporin at an early age (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 403-405 
    Details
    ISSN: 1420-9071
    Keywords: SHR ; cyclosporin ; immune mechanisms ; hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In spontaneously hypertensive rats the effect of the T-cell inhibitor cyclosporin was studied at different ages. If treatment was started at the age of 2 weeks the development of hypertension was delayed, but the ultimate level of blood pressure was not affected. These results indicate the involvement of immune mechanisms in the early development of hypertension in spontaneously hypertensive rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940428
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  • 3
    Electronic Resource
    Electronic Resource
    Pinacidil, a new vasodilator, in the treatment of mild to moderate essential hypertension (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 347-349 
    Details
    ISSN: 1432-1041
    Keywords: pinacidil ; hypertension ; vasodilation ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty three patients with essential hypertension who were uncontrolled on diuretic and/or β-receptor antagonist therapy were treated additionally with the vasodilator, pinacidil, in an open study. Significant reduction in mean blood pressure was achieved. Supine and erect systolic and diastolic blood pressure fell by 44/25 mmHg and 37/24 mmHg respectively over the study period of 12 weeks. Side-effects such as dizziness, headache, facial flushing and mild oedema were experienced by 10 patients during the study, all of which were mild and transient and did not require withdrawal from pinacidil therapy. Pinacidil is an effective and well tolerated agent in the treatment of essential hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543335
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of atenolol 50 mg and 100 mg as initial treatment in uncomplicated mild to moderate hypertension (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 351-352 
    Details
    ISSN: 1432-1041
    Keywords: atenolol ; hypertension ; side-effects ; dose-response relationship ; initial treatments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary After screening a local population in the northern part of The Netherlands for hypertension, 59 patients with a diastolic pressure (DP) between 95 and 130 mmHg were randomized and treated either with 50 mg atenolol (n=29) or 100 mg atenolol (n=30) for 1 month. There was no significant difference between the two treatments, neither in the fall in systolic and diastolic pressures nor in the number of complaints reported. It is concluded that in the initial treatment of uncomplicated mild to moderate hypertension, 100 mg atenolol has no advantage over a 50 mg dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543336
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  • 5
    Electronic Resource
    Electronic Resource
    Treatment of essential hypertension and hypertension associated with renal impairment with pinacidil: A new vasodilator (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 381-386 
    Details
    ISSN: 1432-1041
    Keywords: pinacidil ; renal impairment ; hypertension ; vasodilator ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty patients with uncontrolled hypertension were treated with pinacidil for a mean period of 43 weeks (range 10–63 weeks). All patients achieved and maintained significant reductions in blood pressure. The supine blood pressure at base-line was 184/116 mmHg; after one week it was 161/95 mmHg and at 43 weeks it was 138/79 mmHg. The mean dose of pinacidil was 30 mg/day. There was no significant difference between the two groups with respect to the dose of pinacidil or the blood pressure response. Pulse rate and weight remained stable for the group as a whole. Five patients were not taking beta-blockers. The mean baseline pulse rate for this group was 78 beats/min and when maintained on pinacidil it was 82 beats/min (NS). Six patients were not taking diuretics. The mean baseline weight for this group was 78.5 kg and while maintained on pinacidil it was 79.2 kg (NS). There was no occurrence of oedema, hirsutism or first dose phenomenon. The mean glomerular filtration rate and renal plasma flow for the renal group was 35.4 ml/min and 192.3 ml/min before pinacidil and after six months they were 32.7 ml/min and 183.2 ml/min (NS) respectively. Six patients experienced minor side-effects. We conclude that pinacidil is a potent, well tolerated antihypertensive agent which merits further study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544354
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  • 6
    Electronic Resource
    Electronic Resource
    Haemodynamic effects of indenolol at rest and after a submaximal workload in essential hypertension (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 501-505 
    Details
    ISSN: 1432-1041
    Keywords: hypertension ; indenolol ; submaximal workload ; haemodynamic effects ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of indenolol on heart rate and blood pressure at rest and after submaximal workload has been studied in 19 patients with established essential hypertension. A stepwise increase from moderate to submaximal exercise was chosen to mimic challenges normally occurring in daily life. After 4 weeks of once a day indenolol therapy a significant, gradual reduction in the following cardiovascular parameters was observed: heart rate at rest fell by 20%, 30% after exercise and 31% after recovery; systolic blood pressure showed a fall of 15% at rest, 19% after workload and 14% after recovery; the reduction in diastolic blood pressure was 15% at rest, 11% after exercise and 12% after recovery. The rate-pressure product was decreased by 32% at rest, 43% after exercise and 42% after recovery. It is concluded that the most important pharmacological effect of indenolol is the significant decrease in myocardial oxygen demand. In patients with essential hypertension indenolol not only produces a definite antihypertensive effect, but it also increases workload tolerance and decreases subjective symptoms during physical activity. Compliance was good and no severe side effects were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544058
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of prazosin and alphamethyldopa on blood lipids and lipoproteins in hypertensive patients (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 513-516 
    Details
    ISSN: 1432-1041
    Keywords: prazosin ; alphamethyldopa ; lipoprotein ; hypertension ; blood lipids ; serum parameters ; hydrochlorothiazide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of prazosin and alphamethyldopa on blood lipids and lipoproteins were assessed in 20 patients with mild or moderate arterial hypertension. Parameters measured included serum cholesterol (CHO), triglycerides (TG), high density lipoprotein-cholesterol (HDL-CHO), insulin (I), glucose (G), and non-esterified fatty acids (NEFA). Prazosin — 4 mg/day for 6 weeks in hydrochlorothiazide-treated patients lowered blood pressure by 18.6/17.2 (systolic/diastolic pressure) mmHg. There was a significant decrease in CHO (−5.8%), in I (−16.5%), and in NEFA (−3.0%), and a significant increase in HDL-CHO (+15.5%). Alphamethyldopa 250–750 mg/day for 6 weeks in hydrochlorothiazide-treated patients lowered blood pressure by 18.8/14.6 (systolic/diastolic pressure) mmHg, accompanied by a non-significant decrease in CHO and TG, and significant increases in HDL-CHO (+10.3%), G (+8.5%) and NEFA (+6.4%). Thus, prazosin appears to have a more beneficial effect on blood lipids and lipoproteins than alphamethyldopa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544060
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of captopril and hydrochlorothiazide on the response to pressor agents in hypertensives (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 5-9 
    Details
    ISSN: 1432-1041
    Keywords: captopril ; hydrochlorothiazide ; hypertension ; vascular reactivity ; norepinephrine ; angiotensin II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect on arterial pressure of incremental doses of norepinephrine (2 to 10 µg/min) and angiotensin II (50 to 800 ng/min) administered over 10 min periods was studied in sodium-replete hypertensive patients after crossover oral treatments with placebo, captopril 50 mg in a single dose, captopril 50 mg three times daily for one week and hydrochlorothiazide 50 mg daily for a week. Neither captopril nor hydrochlorothiazide affected the dose response to infusions of angiotensin II. In comparison to placebo responses, however, both single and multiple-dose captopril therapy, and hydrochlorothiazide attenuated the pressor responses to infusions of norepinephrine. Captopril significantly depressed angiotensin converting enzyme activity from predose levels and angiotensin II infusions significantly elevated plasma aldosterone concentrations. These results confirm findings reported for single dose captopril in normotensive volunteers and indicate that attenuation of the vascular responsiveness to sympathetic stimulation may contribute to the antihypertensive effects of captopril and hydrochlorothiazide therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00635700
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  • 9
    Electronic Resource
    Electronic Resource
    Effects of BAYl 5240, a fixed combination of low dose nifedipine and acebutolol on hypertension: Comparison with standard dose nifedipine (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 17-21 
    Details
    ISSN: 1432-1041
    Keywords: nifedipine ; acebutolol ; hypertension ; combination therapy ; double-blind study ; adverse effects ; BAYl 5240
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 116 patients from 4 clinics participated in a double blind study to assess the efficacy of (BAYl 5240), a nifedipine-acebutolol fixed combination (10 mg+100 mg), as compared to nifedipine 20 mg in essential hypertension. During the 10 week study, the mean recumbent blood pressure decreased 1 to 3 h after treatment from 175.5/105.2 to 148.3/88.0 mmHg in the BAY1 5240 group and from 174.3/102.9 to 150.3/86.5 mmHg in the nifedipine group. The results also showed a comparable decrease in the mean systolic (SBP) and diastolic (DBP) blood pressures before treatment (24 h after last tablet) and after physical exertion before and after either drug given for 4 weeks. Doubling of the dose for 4 additional weeks produced a moderate and similar additional decrease in blood pressure. The results show the possibility of treating essential hypertension with a low dose of a beta-adrenergic blocking agent in combination with 10 mg nifedipine. Both regimens were well tolerated. One patient in the BAYl 5240 group and 2 in the nifedipine group, all treated by the same investigator, were withdrawn from the study because of headache during the nifedipine pre-period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00635702
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  • 10
    Electronic Resource
    Electronic Resource
    Bromocriptine reduces plasma noradrenaline and 3,4-dihydroxyphenylacetic acid in normal and hypotensive subjects (1985)
    Springer
    European journal of clinical pharmacology 27 (1985), S. 671-675 
    Details
    ISSN: 1432-1041
    Keywords: bromocriptine ; hypertension ; plasma catecholamines ; 3,4-dihydroxyphenylacetic acid ; peripheral dopamine receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of a single oral dose of bromocriptine 2.5 mg was evaluated in 11 normotensive and 6 hypertensive volunteers. 150 min after drug administration, a significant decrease in plasma noradrenaline concentration from 202 to 124 pg/ml in normotensive and from 197 to 119 pg/ml in hypertensive patients was observed. Plasma 3,4 dihydroxyphenylacetic acid, a major metabolite of dopamine, fell from 1132 to 956 pg/ml in normal subjects and from 1242 to 807 pg/ml in hypertensives. No change in plasma adrenaline was found. At the same time, mean arterial pressure showed a significant decrease from 90 to 81 and from 132 to 111 mmHg in normotensive and hypertensive subjects, respectively. Bromocriptine also inhibited the increase in noradrena-line level that occurred when the subjects changed from the supine to the standing position. The inhibition was more evident in hypertensive subjects. It is suggested that the hypotensive effect of bromocriptine is mediated by the inhibition of noradrenaline release due to the stimulation of dopamine receptors on noradrenergic nerve terminals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547047
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