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  • 2020-2024  (15,673)
  • 2020  (15,673)
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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Translational Neuroscience of Speech and Language Disorders: State of the Art. -2. Translational Neuroscience of Aphasia and Adult Language Rehabilitation. -3. Treatment and intervention approaches for the improvement of language abilities in neurodegenerative diseases -- 4. Neural and Genetic Mechanisms of Dyslexia -- 5. The role of memory systems in neurodevelopmental disorders of language -- 6. Transcranial direct current stimulation (tDCS) and Language/Speech: Can patients benefit from a combined therapeutic approach? -- 7. Transcranial Magnetic Stimulation in Aphasia Rehabilitation -- 8. The Cerebellum: A Therapeutic Target in Treating Speech and Language Disorders -- 9. Navigated rTMS for Mapping the Language Network in Preoperative Settings: Current Status and Future Prospects -- 10. Presurgical Language fMRI in Epilepsy: An Introduction -- 11. Lesion-symptom mapping in speech and language disorders: a translational perspective.
    Abstract: This edited volume provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative conditions on speech and language. It brings together contributions from several leading experts in a markedly broad range of disciplines, including Speech and Language Therapy, Neuropsychology and Neurology, but also Neurosurgery, Neuroimaging and Neurostimulation, as well as Engineering and Genetics.
    Type of Medium: Online Resource
    Pages: XVII, 290 p. 18 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030356873
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 2
    Keywords: Medical genetics. ; Genetics. ; Biotechnology. ; Medical Genetics. ; Genetics and Genomics. ; Chemical Bioengineering.
    Description / Table of Contents: Section I: The physiology of the gene/environment interaction -- Nutrition -- Physical Exercise -- Circadian Rhythm -- Toxicants: Smoke, Alcohol and Heavy Metals -- Hormones -- Section II: Gene-Environment Interaction and Disease Susceptibility -- Obesity and Metabolic Syndromes -- Cancer -- Neurological and Psychiatric Disorders -- Asthma and allergic disorders -- Lamarck Versus Darwin: The Concept of Aquired Epigenetic Inheritance -- Section III: Genome/Epigenome -- Genetic Contribution to Epigenetic Inheritance -- The Controversial Role of DNA Methylation in Epigenetic Inheritance -- Small Non-Coding RNAs -- Chromatin Modifiers -- Soma-to-Germline Information Transfer: Questions and Promises.
    Abstract: The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy. This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.
    Type of Medium: Online Resource
    Pages: VIII, 266 p. 11 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030352134
    DDC: 616.042
    Language: English
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  • 3
    Keywords: Conservation biology. ; Ecology . ; Molecular ecology. ; Animal migration. ; Animal culture. ; Biodiversity. ; Biotic communities. ; Population biology. ; Conservation Biology. ; Molecular Ecology. ; Animal Migration. ; Animal Science. ; Biodiversity. ; Community and Population Ecology.
    Description / Table of Contents: (1) Introduction on different applications of molecular tools to answer novel questions in the field of population genetics/genomics of endangered mammals (Mike Bruford, School of Biosciences, Cardiff University, UK) -- (2) Climate change impact at the genetic level: patterns in the Couesi's rice rat Oryzomys couesi (Ella Vázquez Domínguez, Instituto de Ecología, UNAM, Mexico) -- (3) Use of molecular and demographic data to prioritize populations of black-tailed prairie dogs (Cynomys ludovicianus) from Chihuahua, Mexico for conservation (Luis Eguiarte Fruns, Instituto de Ecología, UNAM, Mexico) -- (4) Anthropogenic and Historic Movements of American Black Bears Shape Contemporary Population Structure (Emily Puckett, Division of Molecular Sciences, University of Missouri, USA) -- (5) How many ESUs are of conservation interest within some species of Neotropical carnivores (Felidae, Canidae, Ursidae, Mustelidae and Procyonidae)? : Individual mitocondrial genes versus mitogenomics (Manuel Ruiz García, Departamento de Biología, Pontificia Universidad Javeriana, Spain) -- (6) Phylogeographic footprint of armadillo colonization in North America (María Clara Arteaga, Departamento de Biología de la Conservación, Mexico) -- (7) Koala conservation in Queensland: a role for a living genome bank in genetic rescue? (Jenny Seddon, School of Veterinary Science, The University of Queensland, Australia) -- (8) Noninvasive genetics sheds light on the status, phylogeography, and evolution of the most elusive carnivores: The case of the snow leopard (Jan Janecka, Department of Biological Sciences, Duquesne University, USA) -- (9) Documenting genetic diversity in changing populations for management and conservation (Jennifer Leonard, Conservation and Evolutionary Genetics, Estación Biológica de Doñana, Spain) -- (10) Conservation genetic of gray brocket deer (Mazama gouazoubira) in the southern of the distribution range (Susana González, Departamento de Biodiversidad y Genética, Universidad de Uruguay) -- (11) Noninvasive Genetic Monitoring of the Elusive European Wildcat as a Tool for Science-Based Wildlife Conservation (Katharina Steyer, Seckenberg Research Institute, Germany) -- (12) Conservation genetics in bats: current progress and future prospects (Serena Dool, University of Greifswald, Germany) -- (13) From dung to demography: Using noninvasive methods to study elephants inside and outside protected areas (Lori Eggert, Division of Biological Sciences, University of Missouri, USA) -- (14) Effect of the habitat connectivity in the genetic variability of the Volcano rabbit (Romerolagus diazi) (Jorge Ortega/Leslie Montes/José Antonio Guerrero, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional) -- (15) Different immune system diversity for city life: comparing major histocompatiblity complex alleles in San Joaquin kit fox (Vulpes macrotis mutica) (Jesus Maldonado/Tammy R Wilbert, Masoumeh Sikaroodi, Brian Cypher, Christine Van Horn Job, Katherine Ralls, and Patrick M. Gillevet, Center for Conservation Genomics, Smithsonian Institue, Washington, DC, USA) -- (16) Conclusion: current state and future prospects of conservation genomics in mammals (Jorge Ortega, Jesus Maldonado).
    Abstract: This book focuses on the use of molecular tools to study small populations of rare and endangered mammals, and presents case studies that apply an evolutionary framework to address innovative questions in the emerging field of mammalian conservation genomics using a highly diverse set of novel molecular tools. Novel and more precise molecular technologies now allow experts in the field of mammology to interpret data in a more contextual and empirical fashion and to better describe the evolutionary and ecological processes that are responsible for the patterns they observe. The book also demonstrates how recent advances in genetic/genomic technologies have been applied to assess the impact of environmental/anthropogenic changes on the health of small populations of mammals. It examines a range of issues in the field of mammalian conservation genomics, such as the role that the genetic diversity of the immune system plays in disease protection and local adaptation; the use of noninvasive techniques and genomic banks as a resource for monitoring and restoring populations; the structuring of population by physical barriers; and genetic diversity. Further, by integrating research from a variety of areas – including population genetics, molecular ecology, systematics, and evolutionary and conservation biology – it enables readers to gain a deeper understanding of the conservation biology of mammals that are at increasing risk of extinction at local, regional and global scales. As such, it offers a unique resource for a broad readership interested in the conservation biology of mammals and conservation management strategies to better preserve biodiversity.
    Type of Medium: Online Resource
    Pages: VII, 378 p. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030333348
    DDC: 333.9516
    Language: English
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  • 4
    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Challenge and Promise: A Snap-Shot on the Molecular Biology of Notch Signaling -- Overview of Basic Mechanisms of Notch Signaling in Development and Disease -- Ligand-induced cis-inhibition of Notch signaling: the role of an extracellular region of Serrate -- Phosphorylation and proteolytic cleavage of Notch in canonical and non-canonical Notch signaling -- Maheshvara a conserved RNA helicase regulates Notch signaling in Drosophila melanogaster -- Molecular Regulation of Notch Signaling by Gremlin -- Regulation of Notch Signaling in Drosophila melanogaster: the role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex -- Interaction of Long Non-Coding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss -- Insulin–dependent non-canonical activation of Notch in Drosophila: a story of Notch-induced muscle stem cells proliferation -- Molecular mechanisms of Notch signaling in lymphoid cell lineages development: NF-κB and beyond -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
    Type of Medium: Online Resource
    Pages: XIII, 172 p. 32 illus., 31 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030364229
    Series Statement: Advances in Experimental Medicine and Biology, 1227
    DDC: 571.978
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Invertebrates. ; Biotechnology. ; Biomaterials. ; Invertebrate Zoology. ; Biotechnology. ; Biomaterials.
    Description / Table of Contents: 1. Polyphenols and flavonoids from honey: Biological applications -- 2. Chemistry and application of lac and its by-products -- 3. Silk: an amazing biomaterial for future medication -- 4. Insect Chitin and Chitosan: Structure, Properties, Production and Implementation Prospective -- 5. Recent advances in the arthropod natural product chemistry -- 6. Silkworm: A Unique Creature for Natural Products -- 7. Present and future prospects on nutritious feeding using insects -- 8. Insect Pheromones and its applications in management of pest population -- 9. Non-Protein chemical compounds from Lepidopteran insect cocoons. .
    Abstract: This book reviews the latest research on bioproducts from various economically important insects, such as silkworms, honey bees, lac and drosophila, and termites, and discusses their general, biomedical and industrial applications in detail. It includes chapters focusing on insects as a food source, probiotics, silk-based biomaterials, insect pheromones, insects as biomedicine source, pupa oil chemistry, non-protein compounds from Lepidopteran insects, insect chitin and chitosan, polyphenols and flavonoids. Model insects like Bombyx mori or bees were domesticated in Asian countries thousands of years ago. Over time, natural products from these animals became industrialized and today they attracting increasing attention thanks to their sustainability and their manifold applications in agriculture and biomedicine. The book is intended for entomologists, material scientists, natural product researchers and biotechnologists. .
    Type of Medium: Online Resource
    Pages: X, 156 p. 44 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030366100
    DDC: 592
    Language: English
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  • 6
    Keywords: Agriculture. ; Agriculture Economic aspects. ; Power resources. ; Food science. ; Sustainability. ; Agriculture. ; Agricultural Economics. ; Natural Resource and Energy Economics. ; Food Science. ; Sustainability.
    Description / Table of Contents: Chapter 1. Food systems in Sri Lanka: components, evolution, challenges and opportunities -- Chapter 2. Nutrition transition in Sri Lanka: a meta-analysis of the nutrition profile -- Chapter 3. Cascaded tank-village system: present status and prospects -- Chapter 4. Soil survey, classification and mapping in Sri Lanka – past, present and future -- Chapter 5. Milestones in the history of rice improvement in Sri Lanka -- Chapter 6. Vegetable breeding in Sri Lanka in retrospect -- Chapter 7. Genetic improvement for sustainability of coconut production: the Sri Lankan experience -- Chapter 8. Breaking the mould: pave the way for future cereals -- Chapter 9. Recent developments in vegetable production technologies in Sri Lanka -- Chapter 10. Input intensification in food crops production and food security -- Chapter 11. A cross section of century-long experiences in entomological research in crop sectors: directions for future research -- Chapter 12. Animal feed production in Sri Lanka: past present and future -- Chapter 13. Livestock and poultry to assure sustainability in the food system -- Chapter 14. Fisheries sector contribution for sustainable food system: past, present and future -- Chapter 15. Evolution of agricultural extension system in Sri Lanka -- Chapter 16. Performance and potential of agricultural insurance: global and Sri Lankan perspectives -- Chapter 17. Agricultural research for sustainable food systems – recommendations with special reference to Sri Lanka.
    Abstract: A food system comprises the entire range of actors and interlinked activities related to food production, processing, distribution, marketing and trade, preparation, consumption, and disposal. When a food system operates without compromising the needs of future generations, it is considered to be a “Sustainable Food System.” The present-day food systems in Sri Lanka are diverse, and the natural and physical environment, infrastructure, institutions, society and culture, and policies and regulations within which the food systems operate, as well as the technologies employed, have shaped their outcomes. Agricultural research is a key factor in terms of innovation and technological advances. Innovation has been the main driver of food systems’ transformation over the past few decades and will be critical to addressing the needs of a rapidly growing population in a context of climate change and scarcity of natural resources. In addition, agricultural research must help meet the rising demand for food at affordable prices. Comprising 17 chapters written by specialist(s) in their respective subject-areas, this Contributed Volume on “Agricultural Research for Sustainable Food Systems in Sri Lanka: A Historical Perspective” shares the scientific knowledge accumulated by the National Agricultural Research System of Sri Lanka, including universities, and offers recommendations on how to make food systems more sustainable in order to address the current needs of Sri Lankan society. It presents perspectives on four key thematic areas, namely: (i) Crop and animal production, management, and improvement, (ii) Agro-product processing technologies, (iii) Natural resource management, and (iv) Socio-economic development and agri-business management.
    Type of Medium: Online Resource
    Pages: XIX, 394 p. 63 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811521522
    DDC: 630
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Anatomy. ; Internal medicine. ; Cytology. ; Biochemistry. ; Neuroscience. ; Anatomy. ; Internal Medicine. ; Cell Biology. ; Biochemistry.
    Description / Table of Contents: Neurosecretion: A Historical Overview -- Neurosecretion: Hypothalamic Somata versus Neurohypophysial Terminals -- Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus -- Somato-Dendritic Secretion of Neuropeptides -- Neurosecretory Vesicles: Structure, Distribution, Release and Breakdown -- Molecular Controls on Regulated Neurotransmitter and Neurohormone Secretion -- Secretory Astrocytes -- Action Potential-Induced Ca2+ Influx for Both Acute and Sustained Insulin Secretion in Pancreatic Beta Cells -- Plasticity in the Morphology of Lactotrophs and Folliculo-Stellate Cells and Prolactin Secretion -- Neuroendocrine and Metabolic Regulation of Plasma Growth Hormone Secretory Profiles -- Role of the TWIK-Related Potassium (TREK)-1 Channels in the Regulation of Adrenocorticotropic Hormone (ACTH) Secretion from Pituitary Corticotropes -- How Do Bacterial Neurotoxins Affect Neurosecretion? -- Secretory Mechanisms in Paramecium.
    Abstract: How do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: state‐dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted. While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows. This is the eighth volume in the Masterclass in Neuroendocrinology series* - now a co-publication between Springer Nature and the INF (International Neuroendocrine Federation). *Volumes 1-7 published by Wiley.
    Type of Medium: Online Resource
    Pages: XIII, 307 p. 65 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030229894
    Series Statement: Masterclass in Neuroendocrinology, 8
    DDC: 612.8
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Microbial genetics. ; Evolution (Biology). ; Population genetics. ; Microbial ecology. ; Medical genetics. ; Genetics. ; Microbial Genetics. ; Evolutionary Biology. ; Population Genetics. ; Microbial Ecology. ; Medical Genetics. ; Genetics and Genomics.
    Description / Table of Contents: Part 1: Genomic diversity and the pan-genome concept -- Chapter 1: The pan-genome: a data-drivendiscovery in biology -- Chapter 2: The prokaryotic species concept and challenges -- Chapter 3: Bacterial guide on how to design a diversified gene portfolio -- Chapter 4: A review of pan-genome tools and recent studies -- Part 2: Evolutionary biology of pan-genomes -- Chapter 5: Structure and dynamics of bacterial populations: pan-genome ecology -- Chapter 6: Bacterial microevolution and the pan-genome -- Chapter 7: Pan-genomes and selection: the public goods hypothesis -- Chapter 8: A pan-genomic perspective on the emergence, maintenance and predictability of antibiotic resistance -- Part 3: Pan-genomics: an open, evolving discipline -- Chapter 9: Metapangenome: at the crossroad of pangenomics and metagenomics -- Chapter 10: Pan-genome flux balance analysis towards pan-phenomes -- Chapter 11: Bacterial epigenomics: epigenetics in the age of population genomics -- Chapter 12: Eukaryotic pan-genomes -- Chapter 13: Computational strategies for eukaryotic pan-genome analyses.
    Abstract: This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
    Type of Medium: Online Resource
    Pages: XIV, 307 p. 47 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030382810
    DDC: 579.135
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant genetics. ; Plant biotechnology. ; Agriculture. ; Plant Genetics. ; Plant Biotechnology. ; Agriculture.
    Description / Table of Contents: Citrus origin, diffusion and economic importance -- Genetic resources of Citrus and related genera -- Conventional breeding of cultivated varieties -- Conventional breeding of rootstocks -- Ploidy manipulation as breeding strategy -- Markers, maps and marker-assisted selection -- From the draft genome of sweet orange toward a pan-genome -- New Breeding Techniques for Citrus -- From flower to fruit in citrus -- Genetic control of ripening -- Pigments in citrus: importance and genetic background -- Essential oils in citrus -- Abiotic stress resistance -- Biotechnological approaches for the resistance to citrus huanglongbling -- Genetic basis of canker resistance -- Molecular mechanisms for resistance to biotic stresses -- Future perspectives.
    Abstract: This book reviews how the release of the citrus genome facilitates the investigation of ancestral species, the study of their complex biological features, and the genetic basis of agronomic traits of paramount importance for their sustainable cultivation. The first chapters discuss citrus origin and distribution, and the economic importance and varietal composition of the cultivated species, providing an overview of citrus and related genera genetic resources. The book then describes the role of traditional breeding techniques (for scion and rootstocks) as well as the potential of genomic breeding and innovative protocols for biotechnological approaches. The second part provides essential information on the genus Citrus, the attributes of pure citrus species, genetic admixtures, hybrids and citrus relatives, and on the horticultural classification of cultivated species, varieties and rootstocks. The third part then focuses on the different molecular mechanisms, covering various aspects of citrus biology, including the role of beneficial compounds of citrus fruits. In addition, it examines the molecular responses of citrus to abiotic stresses and to field and post-harvest diseases. Providing insights gained in recent years, it is a valuable guide for those who are interested in gene discovery, comparative genomics, molecular breeding and new breeding techniques. It is particularly useful for scientists, breeders and students at universities and public sector institutes involved in research for the citrus industry.
    Type of Medium: Online Resource
    Pages: XIV, 294 p. 33 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030153083
    Series Statement: Compendium of Plant Genomes,
    DDC: 581.35
    Language: English
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  • 10
    Keywords: Medical microbiology. ; Industrial microbiology. ; Plant genetics. ; Pharmacology. ; Microbial genetics. ; Medical Microbiology. ; Industrial Microbiology. ; Plant Genetics. ; Pharmacology. ; Microbial Genetics.
    Description / Table of Contents: Chapter 1. The Artemisia genus: Panacea to Several Maladies -- Chapter 2. Bacopa monnieri: the Neuroprotective Elixir from the East: Phytochemistry, Pharmacology and Biotechnological Improvement -- Chapter 3. Current knowledge of Cinnamomum species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies -- Chapter 4. Swertia spp. : A potential source of high-value bioactive components, Pharmacology and Analytical techniques -- Chapter 5. The Genus Calophyllum: Review of Ethnomedicinal uses, Phytochemistry and Pharmacology -- Chapter 6. Plant Derived Quinones as a Source of Antibacterial and Anticancer Agents -- Chapter 7. Drugging protein-protein interaction interface with natural products: a computational approach -- Chapter 8. CQDs derived from natural sources: Excellent bio-imaging agents -- Chapter 9. Microbial Natural products: Recent insights into novel applications -- Chapter 10. Bioactive peptides and carbohydrates from natural products: a source of functional foods and nutraceuticals -- Chapter 11. Metabolites of fluorescent pseudomonads and their antimicrobial and anticancer potentials -- Chapter 12. Medicinal fungi: A natural source of pharmacologically important metabolites -- Chapter 13. Ganoderma: A propitious medicinal poroid mushroom -- Chapter 14. Pharmaceutically important metabolites from marine Fungi -- Chapter 15. Endophytic fungi: a trove of novel bioactive compounds -- Chapter 16. Novel Products from Microalgae -- Chapter 17. Lactic Acid Production and its Application in pharmaceuticals -- Chapter 18. Microbial Clot Busters: an Overview of Source, Production, Properties and Fibrinolytic Activity -- Chapter 19. Carbohydrate biopolymers: Diversity, applications and challenges -- Chapter 20. Biotechnological aspects of nanoparticles driven from natural products for drug delivery system and other applications -- Chapter 21. Methods and Techniques for the Chemical Profiling and Quality Control of Natural Products and Natural Product Driven Drugs -- Chapter 22. Characterization of Bioactive Secondary Metabolites of Fungal Endophytes -- Chapter 23. Modulation of Cellular Protein Quality Control Pathways Using Small Natural Molecules -- Chapter 24. Elaborating on the potential for mushroom-based products market expansion: Consumers’ attitudes and purchasing intentions -- Chapter 25. The Role of Algae in Nutraceutical and Pharmaceutical Production -- Chapter 26. Microbial interventions to induce secondary metabolites biosynthesis in medicinal and aromatic plants -- Chapter 27. Peptaibols: Antimicrobial peptides from Fungi.
    Abstract: This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.
    Type of Medium: Online Resource
    Pages: XII, 733 p. 96 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811513947
    DDC: 616.9041
    Language: English
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  • 11
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Cardiology. ; Therapeutics. ; Heart Surgery. ; Pharmacology. ; Cardiology. ; Therapeutics. ; Cardiac Surgery.
    Description / Table of Contents: Coronary Artery Disease: From Mechanism to Clinical Practice -- Evidence in guidelines for treatment of coronary artery disease -- Revascularization For Coronary Artery Disease: Principle And Challenges -- Antithrombotic drugs: pharmacology and perspectives -- Lipid modifying drugs: pharmacology and perspectives -- Anti-hypertensive drugs: pharmacology and perspectives -- Pharmaceutical treatment for Heart failure -- Drug discovery for coronary artery disease.
    Abstract: This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.
    Type of Medium: Online Resource
    Pages: IX, 339 p. 7 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811525179
    Series Statement: Advances in Experimental Medicine and Biology, 1177
    DDC: 615
    Language: English
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  • 12
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Animal culture. ; Physiology. ; Biochemistry. ; Conservation biology. ; Ecology . ; Embryology. ; Animal Science. ; Animal Physiology. ; Chemical Biology. ; Conservation Biology. ; Embryology.
    Description / Table of Contents: Chapter 1: Reproductive physiology in fishes -- Chapter 2: Endocrine regulation of reproduction with special emphasis on gametogenesis in fishes -- Chapter 3: Factors influencing milt quality in fishes and its usefulness to cryopreservation -- Chapter 4: Energetics of fish spermatozoa -- Chapter 5: Fish sperm quality evaluation after cryopreservation -- Chapter 6: Cryopreservation – History and Development -- Chapter 7: Cryopreservation of fish gametes- an overview -- Chapter 8: Cryopreservation and short duration storage of germ cells and male gametes of freshwater fishes -- Chapter 9: Cryopreservation of marine fish sperm -- Chapter 10: Sperm cryopreservation in crustaceans -- Chapter 11: State of the art in cryopreservation of bivalve spermatozoa -- Chapter 12: Cryopreservation of germ stem cells in fishes -- Chapter 13: Cryopreservation and storage of oocytes, embryos and embryonic cells of fish -- Chapter 14: Potential of fish gamete cryopreservation in conservation programs in Bangladesh -- Chapter 15: Gamete manipulation and conservation for genetic improvement in penaeid shrimp.
    Abstract: Understanding the reproductive physiology and endocrinology of fishes is essential for captive maturation and seed production in the field of aquaculture. Studying the spermatology of fishes is a comparatively new focus in aquaculture, which has emerged as an important area of fish research over the past two decades. In this regard, the cryopreservation of fish gametes is a crucial aspect. Moreover, energetics studies of gametes have become essential, considering the loss of vigour in the spermatozoa after cryopreservation. The latest development in this context is the cryopreservation of spermatogonial stem cell, which is also covered in the book, along with detailed information on embryo cryopreservation in fishes and crustaceans. The role of cryopreservation in conservation programmes is another important aspect, one that will especially interest biologists. This book addresses central issues in fish gamete cryopreservation and breeding, while also reviewing the history of cryopreservation. Its most unique feature is the breadth of its coverage, from basic information on reproduction in fishes, to such advanced topics as embryo cryopreservation. Chiefly intended as a handy troubleshooting guide, the book represents a valuable resource for research students in related fields.
    Type of Medium: Online Resource
    Pages: IX, 352 p. 54 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811540257
    DDC: 636
    Language: English
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  • 13
    Keywords: Biotechnology. ; Plant diseases. ; Microbial ecology. ; Bacteria. ; Biology Technique. ; Biotechnology. ; Plant Pathology. ; Microbial Ecology. ; Bacteria. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Hairy Roots Biotechnology Unzipped: A Journey of Reality and Promises -- Chapter 2. Hairy Roots as a Source of Tropane Alkaloids -- Chapter 3. Induction, Metabolite Analysis and Transgenesis of Hairy Roots From Coleus Forskohlii -- Chapter 4. Establishment of Hairy Roots of Endangered Himalayan Plantswertiachirata: A Sustainable Alternative to Extraction from Nature -- Chapter 5. A Protocol for the Selection of Spontaneous Variants From Established Catharanthusroseus Hairy Root Cultures -- Chapter 6. Strategies for the Optimization of Culture Conditions for Increasing Metabolite Production Through Hairy Root Cultures. Monoterpenoid Indole Alkaloid Production in Catharanthus Roseus Hairy Roots -- Chapter 7. Protocol for Enhanced Withaferin-a Production in Elicited Withania Somnifera (l.)Dunal Hairy Root Cultures -- Chapter 8. Establishment of Hairy Root Cultures of Pentalinonandrieuxii for the Production of Betulinic Acid -- Chapter 9. Tropane Alkaloid Production by the Establishment Of Hairy Root Cultures of Brugmansia Candida and Elicitation -- Chapter 10. Elicitation as an Essential Strategy For Enhancing Anthraquinone Accumulation In Hairy Root Cultures of Rubia Tinctorum -- Chapter 11. Establishment of Hairy Root Cultures for the Production of Biopharmaceuticals and Optimization of Methods for Recombinant Protein Secretion In The Culture Medium -- Chapter 12. An Improved Protocol for Agrobacterium Rhizogenes-Mediated Transformation of Recalcitrant Plants for Root Biology Studies: A Case Study of Tea Plants (Camellia Sinensis Var. Sinensis) -- Chapter 13 Functional Analysis of Plant Genes Related to Arbuscular Mycorrhiza Symbiosis Using Agrobacterium Rhizogenes-Mediated Root Transformation and Hairy Root Production -- Chapter 14. Functional Characterization of Genes Involved in Legume Nodulation Using Hairy Root Cultures -- Chapter 15. Fluidigm Biomark Diagnostic Panel for Analysis of the Expression of Nicotiana Tabacum Genes, Associated with Alkaloid Synthesis. .
    Abstract: The book discusses the various methods and protocols available in hairy root culture-based research. The utilization of Agrobacterium mediated genetic transformation and establishment of hairy root cultures has paved the way for large-scale secondary metabolite production in medicinal plants. Presenting recent research and offering insights from eminent research groups, the book covers a range of topics related to hairy root-based applications, including (i) establishment of hairy roots and native production of SM (ii) yield enhancement strategies for increased SM production, like elicitation (iii) hairy roots as a tool for value-added applications such as plant-microbe interaction, characterization of plant genes and root biology studies. As such it is an informative guide and experimental manual for researchers in diverse fields of plant biology.
    Type of Medium: Online Resource
    Pages: XIV, 237 p. 47 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811540554
    Series Statement: Rhizosphere Biology,
    DDC: 660.6
    Language: English
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  • 14
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Surfaces (Physics). ; System theory. ; Zoology. ; Botany. ; Biology Technique. ; Computational and Systems Biology. ; Surface and Interface and Thin Film. ; Complex Systems. ; Zoology. ; Plant Science. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Various methods of pattern formation -- Chapter 3. Clusterization of biological structures with high aspect ratio -- Chapter 4. Contact between biological attachment devices and rough -- Chapter 5. Anisotropic friction in biological systems -- Chapter 6. Mechanical interlocking of biological fasteners -- Chapter 7. Biomechanics at the microscale -- Chapter 8. Nanoscale pattern formation in biological surfaces -- Chapter 9. Ecology and evolution.
    Abstract: Basic laws of nature are rather simple, but observed biological structures and their dynamic behaviors are unbelievably complicated. This book is devoted to a study of this “strange” relationship by applying mathematical modeling to various structures and phenomena in biology, such as surface patterns, bioadhesion, locomotion, predator-prey behavior, seed dispersal, etc. and revealing a kind of self-organization in these phenomena. In spite of diversity of biological systems considered, two main questions are (1) what does self-organization in biology mean mathematically and (2) how one can apply this knowledge to generate new knowledge about behavior of particular biological system? We believe that this kind of “biomimetics” in computer will lead to better understanding of biological phenomena and possibly towards development of technical implications based on our modeling.
    Type of Medium: Online Resource
    Pages: XVIII, 317 p. 151 illus., 69 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030415280
    Series Statement: Biologically-Inspired Systems, 16
    DDC: 570.285
    Language: English
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  • 15
    Keywords: Invertebrates. ; Invertebrate Zoology.
    Description / Table of Contents: 1. Agriculture and Impact of Invasive Species to Productivity in Africa -- 2. Bioassay-Guided Isolation of Active Phytochemicals Against Tuta Absoluta (Meyrick) from Turraea Floribunda and Caesalpinia Welwitschiana -- 3. Tuta Absoluta (Meyrick): Seasonal Abundance and Susceptibility of some Tomato Genotypes in Gezira State, Sudan -- 4. Evaluation of Resistance and Toxicity of different Insecticides on Tuta absoluta Meyrick Populations in Major Tomato Growing States of Nigeria -- 5. The First Effort at Adopting Integrated Pest Management IPM to Contain the Infestation of the Tuta Absoluta in Nigeria -- 6. New Record of Tuta Absoluta on Cowpea Vigna Unguiculata, Gezira State, Sudan -- 7. Efficacy of a Sudanese Strain of Entomopathogenic Fungus, Metarhizium Anisopliae Met. Sorokin on Puparia of Bactrocera Dorsalis Hendel, under Laboratory Conditions -- 8. Taxonomic keys to Economic Fruit Flies (Diptera: Tephritidae) of the Sudan -- 9. Injury and Yield Losses due to the Maize Stem Borer Busseola Fusca (Fuller) (Lepidoptera: Noctuidae) on Smallholder farms. -- 10. Establishment of an Exotic Parasitoid Cotesia vestalis in Coastal Areas of Kenya as Biological Control Agent of Plutella Xylostella -- 11. Enhancing Monitoring Efficiency and Management of Vectors of Maize Lethal Necrosis Disease in Kenya -- 12. Outbreak of fall Armyworm (Spodoptera Frugiperda) and its Impact in Rwanda Agriculture Production -- 13. Farmers’ Perceptions and Preferences on Pesticide use in the Management of Fall armyworm in Rwanda -- 14. Chronological Review of Fruit Fly Research and Management Practices in Sudan -- 15. Integrated Pest Management for Control the Date Palm Green Pit Scale Insect Palmapsis Phoenicis Ra (Homoptera: Asterolecaniidae) in Sudan -- 16. Use of Para-Pheromone Methyl Eugenol for Suppression of the Mango Fruit Fly, Bactrocera Dorsalis (Hendel) (Diptera:Tephritidae) in Southern Ethiopia -- 17. Sudan Thematic Implementation Plan for the Management of Invasive Red Palm Weevil (RPW), Rhynchophorus Ferrugineus (Olivier) -- 18. Management of Pests of Quarantine Importance in Ghana’s Export Vegetables (Chili, Eggplant and Ridged Gourds) -- 19. The Role of Plantwise in Improving Detection and Action on Pest Situations -- 20. Semiochemical-Baited Autodissemination Device for Managing BFT on Cowpea -- 21. Influence of Predatory Mites, Phytoseiulus Longipes Evans. on the Within-Plant Diurnal Migration and Distribution of the Red Spider Mite, Tetranychus Evansi, Baker and Pritchard on African Nightshade, Solanum Scabrum -- 22. Effects and Persistence of Endophytic Beauveria Bassiana in Tomato Varieties on Mite Density Tetranychus Evansi in the Screenhouse -- 23. Flight Behaviour and Activity Time of Tuta absoluta (Meyrick) Males Trapped on Tomato and Miscellaneous Crops, Gezira State, Sudan.
    Abstract: Invasive species, generally, affect economically important crops, thus affecting the livelihoods of millions of people along crop value chains. Typically, invasive species have high migratory capabilities and, because of plant material exchanges made during trade, they cannot be contained by one country. Usually, African countries react after a pest has invaded and established itself in the country, making the cost of mitigating the pest even more expensive. This book presents a pan-African view of the impacts of invasive insect pests on agriculture and of how invasive species impact on productivity in Africa. It not only describes their importance, but also presents a diversity of research findings in the field, ranging from the use of early warning and monitoring systems for quarantine purposes, agricultural extension, all the way to control strategies. The IPM arsenal presented in this book includes the use of botanical bioactive compounds, semiochemicals, resistant varieties, biological control agents such as entomopathogens, endophytes, predators, and natural enemies. Aspects of technology transfer strategies, regional coordination, and farmers’ perceptions have not been overlooked, because these affect the adoption of mitigation strategies. The book also presents measures that would help agricultural research services to estimate the damage and take actions for preparedness and readiness to face invasive insect pests. This starts with a basic knowledge of taxonomy to enable concerned persons to describe the insects and the vast inventory of affected crops. Physiological and ecological aspects of invasive pests are strongly highlighted to strengthen Integrated Pest Management Strategies. The threat of invasive species will remain permanent; therefore, the book encourages knowledge exchange and collaboration between researchers and scientists on the continent, while encouraging the establishment of a platform or a fund for preparedness and rapid response.
    Type of Medium: Online Resource
    Pages: XXVI, 303 p. 64 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030410834
    Series Statement: Sustainability in Plant and Crop Protection, 14
    DDC: 592
    Language: English
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  • 16
    Keywords: Evolution (Biology). ; Astrobiology. ; Planetary science. ; Evolutionary Biology. ; Astrobiology. ; Planetary Science.
    Description / Table of Contents: Preface -- Chapter 1. What is astrobiology? -- Chapter 2. Astrobiology and Planetary Sciences in Mexico -- Chapter 3. Was LUCA a Hyperthermophilic Prokaryote? The Impact-Bottleneck Hypothesis Revisited -- Chapter 4. Stromatolites, Biosignatures, and Astrobiological Implications -- Chapter 5. The global distribution of modern microbialites: not so uncommon after all -- Chapter 6. The importance of the rare biosphere for astrobiological studies and the diversification and resilience of life on Earth -- Chapter 7. Bacterial communities from deep-hydrothermal systems: the southern Gulf of California as an example of primeval environments -- Chapter 8. Andean Microbial Ecosystems: traces in hypersaline lakes about life origin -- Chapter 9. Stromatolites in crater-lake Alchichica and Bacalar lagoon -- Chapter 10. The origin and early evolution of life on Earth: A laboratory in the School of Science -- Chapter 11. Cuatro Ciénegas as an Archaean Astrobiology Park -- Index.
    Abstract: Astrobiology not only investigates how early life took hold of our planet but also life on other planets – both in our Solar System and beyond – and their potential for habitability. The book take readers from the scars on planetary surfaces made by space rocks to the history of the Solar System narrated by those space rocks as well as exoplanets in other planetary systems. But the true question is how life arose here or elsewhere. Modern comparative genomics has revealed that Darwin was correct; a set of highly conserved genes and cellular functions indicate that all life is related by common ancestry. The Last Universal Common Ancestor or LUCA sits at the base of the Tree of Life. However, once that life took hold, it started to diversify and form complex microbial communities that are known as microbial mats and stromatolites. Due to their long evolutionary history and abundance on modern Earth, research on the biological, chemical and geological processes of stromatolite formation has provided important insights into the field of astrobiology. Many of these microbialite-containing ecosystems have been used as models for astrobiology, and NASA mission analogs including Shark Bay, Pavilion and Kelly Lakes. Modern microbialites represent natural laboratories to study primordial ecosystems and provide proxies for how life could evolve on other planets. However, few viral metagenomic studies (i.e., viromes) have been conducted in microbialites, which are not only an important part of the community but also mirror its biodiversity. This book focuses on particularly interesting sites such as Andean lake microbialites, a proxy of early life since they are characterized by very high UV light, while Alchichica and Bacalar lakes are characterized by high-salt and oligotrophic waters that nurture stromatolites. However, it is only the oasis of Cuatro Ciénegas Basin in México that stored past life in its marine sediments of the Sierra de San Marcos. This particular Sierra has a magmatic pouch that moves the deep aquifer to the surface in a cycle of sun drenched life and back to the depths of the magmatic life in an ancient cycle that now is broken by the overexploitation of the surface water as well as the deep aquifer in order to irrigate alfalfa in the desert. The anthropocene, the era of human folly, is killing this unique time machine and with it the memory of the planet.
    Type of Medium: Online Resource
    Pages: VIII, 232 p. 41 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030460877
    Series Statement: Cuatro Ciénegas Basin: An Endangered Hyperdiverse Oasis,
    DDC: 576.8
    Language: English
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  • 17
    Keywords: Agriculture. ; Microtechnology. ; Microelectromechanical systems. ; Environmental chemistry. ; Nanochemistry. ; Environmental policy. ; Agriculture. ; Microsystems and MEMS. ; Environmental Chemistry. ; Nanochemistry. ; Environmental Policy.
    Description / Table of Contents: Chapter 1 - State of the art of the development of nanopesticides and their potential benefits -- Chapter 2 - Understanding the interaction of nanopesticides with plants -- Chapter 3 - Study of the interaction of nanopesticides with soil microbiota -- Chapter 4 - Methods for understanding the interaction of nanopesticides with soil and water -- Chapter 5 - State of the art in ecotoxicological assays to study the effects of nanopesticides against non-target organisms -- Chapter 6 - Nanoherbicides -- Chapter 7 - Nanoinsecticides -- Chapter 8 - Nanofungicides -- Chapter 9 - Alternative models for initial screening of nanopesticides safety -- Chapter 10 - Methods for the evaluation toxicological effects of nanopesticides in humans -- Chapter 11 - Use of DNA/RNA and nanotechnology aiming pest control -- Chapter 12 - Regulatory issues regarding Nanopesticides Chapter 13 - Nanopesticides: from the bench to the market -- Chapter 14 - Nanopesticides: risk analysis.
    Abstract: This book explores the development of nanopesticides and tests of their biological activity against target organisms. It also covers the effects of nanopesticides in the aquatic and terrestrial environments, along with related subjects including fate, behaviour, mechanisms of action and toxicity. Moreover, the book discusses the potential risks of nanopesticides for non-target organisms, as well as regulatory issues and future perspectives.
    Type of Medium: Online Resource
    Pages: XXI, 360 p. 56 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030448738
    DDC: 630
    Language: English
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  • 18
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Pediatrics. ; Pharmacology. ; Pediatrics.
    Description / Table of Contents: Anti-epileptic drugs in pediatrics -- Current and new therapies for Duchenne Muscular Dystrophy -- Lysosomal diseases -- Mitochondriopathies -- Endocrinology thyroid, pituitary, growth stimulant, growth reduction -- Bone disease – bisphosphonates -- Diabetes type 1 and 3 (insulin; sulfonylurea; others) -- Diabetes type 2 (metformin etc.) -- Dermatology – part 1 urticaria, atopic dermatitis -- Dermatology part 2, ichtyosis, psoriasis -- Cardiovascular part 1- catcholamines, inotropic -- Cardiovascular part 2 – antiarhythmica, anti hypertensives -- Nephrology – dialysis -- How to use drugs in obese children and adolescents -- Haematology – CSFs, erythropoietin -- Antiretroviral/HIV -- Clinical pharmacology and pharmacometrics to better understand physiological changes during pregnancy and neonatal life -- Antihelminth treatment -- Inflammatory bowel disease -- Constipation; laxatives -- Psychiatric diseases in children and adolescents -- Oncology – cell reducing agents part 1, part 2, part 3 -- Immunosuppressants – organ transplantation -- Bone marrow/stem cell transplantation -- Narcotic sparing approaches and the shift towards paracetamol in neonatal intensive care -- Disorders of puberty: pharmacotherapeutic strategies for management.
    Abstract: This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.
    Type of Medium: Online Resource
    Pages: VIII, 538 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504946
    Series Statement: Handbook of Experimental Pharmacology, 261
    DDC: 615
    Language: English
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  • 19
    Keywords: Evolution (Biology). ; Plant genetics. ; Genetics. ; Microbial genetics. ; Evolutionary Theory. ; Plant Genetics. ; Genetics and Genomics. ; Microbial Genetics.
    Abstract: This book presents a comprehensive overview of DNA barcoding and molecular phylogeny, along with a number of case studies. It discusses a number of areas where DNA barcoding can be applied, such as clinical microbiology, especially in relation to infection management; DNA database management; and plant -animal interactions, and also presents valuable information on the DNA barcoding and molecular phylogeny of microbes, algae, elasmobranchs, fishes, birds and ruminant mammals. Furthermore it features unique case studies describing DNA barcoding of reptiles dwelling in Saudi Arabian deserts, genetic variation studies in both wild and hatchery populations of Anabas testudineus, DNA barcoding and molecular phylogeny of Ichthyoplankton and juvenile fishes of Kuantan River in Malaysia, and barcoding and molecular phylogenetic analysis of indigenous bacteria from fishes dwelling in a tropical tidal river. Moreover, since prompt identification and management of invasive species is vital to prevent economic and ecological loss, the book includes a chapter on DNA barcoding of invasive species. Given its scope, this book will appeal not only to researchers, teachers and students around the globe, but also to general readers.
    Type of Medium: Online Resource
    Pages: VI, 267 p. 41 illus., 23 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030500757
    DDC: 576.801
    Language: English
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  • 20
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Agriculture. ; Plant physiology. ; Plant Science. ; Agriculture. ; Plant Physiology.
    Description / Table of Contents: Chapter 1. Introduction to MAPs in the North America -- Chapter 2. Dr. Duke's Phytochemical and Ethnobotanical databases, a cornerstone in the validation of ethnoveterinary medicinal plants, as demonstrated by data on pets in British Columbia -- Chapter 3. Pharmacopoeial Wild Medicinal Plants of North America -- Chapter 4. Medicinal Plant Products, a Discussion of Actual or Probable versus Perceived Sources -- Chapter 5. Juniper species in North America to the same species in Europe with respect to phytochemistry and bioactivity -- Chapter 6. Mentha Genetic Diversity at the US National Clonal Germplasm Repository in Corvallis, Oregon -- Chapter 7. Advances in the research of basil -- Chapter 8. Advances in ther research of catnip -- Chapter 9. Diversity, conservation and sustainable harvest of medicinal plants in North America -- Chapter 10. The Great botanist, Jim Duke -- Chapter 11. TBC -- Chapter 12. Taxol or the story of the American yew -- Chapter 13. The Indian Tobacco -- Chapter 14. The American Elderberry -- Chapter 15. The American Ginseng.
    Abstract: This volume is aimed at offering an insight into the present knowledge of the vast domain of Medicinal and Aromatic Plants with a focus on North America. In this era of global climate change the volume is meant to provide an important contribution to a better understanding of the diverse world of Medicinal and Aromatic Plant research, production and utilization.
    Type of Medium: Online Resource
    Pages: VIII, 342 p. 59 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030449308
    Series Statement: Medicinal and Aromatic Plants of the World, 6
    DDC: 580
    Language: English
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  • 21
    Keywords: Invertebrates. ; Applied ecology. ; Biodiversity. ; Microbial ecology. ; Conservation biology. ; Ecology . ; Forestry. ; Invertebrate Zoology. ; Applied Ecology. ; Biodiversity. ; Microbial Ecology. ; Conservation Biology. ; Forestry.
    Description / Table of Contents: 1. Preface -- 2. Improving the efficacy of biological control by ecostacking -- 3. Integrative biological control approaches in Chinese agriculture, Biodiversity enhancement for improving biological control -- 4. Perennial wildflower strips to enhance natural enemies of insect pests in Belgium -- 5. Flower strips for ecosytem services in Switzerland, Felix Herzog, Agroscope, Zurich Switzerland -- 6. Enhancement of natural control functioning of rice insect pests by manipulating biodiversity in rice-based ecosystems -- 7. Cover crops enhance biological control of insect pests in apple orchards in China -- 8. Enhancement of natural control function in aphids by intercropping and infochemical releasers in wheat ecosystem -- 9. Crop diversity and disease control,Specific techniques to enhance ecostacking -- 10. Ecological enhancement of arthropod natural enemy application in biological control -- 11. Chemical ecology of egg parasitoids in crop protection -- 12. Current knowledge on the migratory moth Autographa gamma as basis for future chemo-ecological research -- 13. The development of biocontrol products and their applications in the field -- 14. Effects of insecticides on pollen beetles (Brassicogethes aeneus) and their tersilochine parasitoids in Germany -- 15. How microbiome approaches can assist market development for biological control -- 16. Successful use of entomopathogenic nematodes to control a defoliator outbreak in an environmentally sensitive area -- 17. Bees and medicinal plants -- 18. Climate change implications -- 19. Night warming on predator-prey interactions: implications for biological control -- 20. Landscape-level drivers of biocontrol and case study from local to regional scale under climate change in China -- 21. Spotted Wing Drosophila-blueberry interactions.
    Abstract: This book is the first to integrate biological control into a conceptual framework – ecostacking - uniting all aspects of biological control and ecosystem services. In 2018 the "First International Congress of Biological Control" was organised and held in Beijing, China. The chapters highlight some of the achievements presented at the congress, worldwide. Of particular significance are the numerous contributions by Chinese researchers illustrating the remarkable progress made on developing and adopting multiple biological control strategies over vast agricultural areas, largely replacing chemical pesticides for sustainable agricultural and horticultural production. In many parts of the world including Europe, fragmented research based on short-term funding has been unable to answer to the needs to develop sustainable long-term solutions to crop protection, while colleagues in China have been successful in implementing programs that exemplify the power of the ecostacking approach. Key contributions by European and US specialists combined with the expertise and experiences by the Chinese contributors comprise the building blocks for the integration of biological control approaches into the overall frame of ecostacking. This book will lead the way to a broader, integrated adoption of biological control techniques in sustainable pest, disease and weed management supporting also the functioning of other key ecosystem services. Chapter 2 of this book is available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 248 p. 63 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030448387
    Series Statement: Progress in Biological Control, 20
    DDC: 592
    Language: English
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  • 22
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Surgery. ; Neurology . ; Nervous system Radiography. ; Neuropsychology. ; Neurosurgery. ; Neurology. ; Neuroradiology. ; Neuropsychology.
    Description / Table of Contents: History of Epilepsy Surgery -- Epilepsy: Clinical, Epidemiological, and Therapeutical Aspects -- Presurgical Evaluation -- Surgical Tools and Techniques -- Anesthesia -- Temporal Lobe Resections -- Extratemporal Resections -- Hemispherical Procedures -- Long-Term Epilepsy-Associated Tumors (LEATs) -- MRI-Negative Epilepsies -- Pediatric Epilepsy Surgery -- Reoperations after failed surgery -- Pathology in Epilepsy Surgery -- Non-Resective Epilepsy Surgery -- Complications -- Cost-Effectiveness of Epilepsy Surgery -- The current Place of Epilepsy Surgery -- A personal view.
    Abstract: This book fills the gap between the increasing demand for epilepsy surgical experience and limited training facilities in this area. It comprehensively describes surgical techniques, including tricks and pitfalls, based on the author’s 30 years of experience, providing optimal and effective training for young neurosurgeons by avoiding learning by trial and error. Moreover, it also includes useful information for epileptologists and other professionals involved in the epilepsy surgical program to allow them to gain a better understanding of possibilities and limitations of epilepsy surgery. .
    Type of Medium: Online Resource
    Pages: XXI, 404 p. 154 illus., 111 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030487485
    DDC: 617.48
    Language: English
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  • 23
    Keywords: Conservation biology. ; Ecology . ; Environment. ; Biotechnology. ; Pollution. ; Earth sciences. ; Geography. ; Conservation Biology. ; Environmental Sciences. ; Biotechnology. ; Pollution. ; Earth and Environmental Sciences.
    Description / Table of Contents: Preface -- Concerns and Threats of Heavy Metals Contamination on Aquatic Ecosystem -- Pollution in Aquatic Environs: Sources and consequences -- A Recent Scenario of Groundwater Quality in Northwest Himalaya, India -- Polycyclic aromatic hydrocarbons: Toxic Effects and their Bioremediation Strategies -- Mechanisms and importance of phytoremediation -- Role of Soil Biota and Associated Threats -- Viability of in-situ and ex-situ bioremediation approaches for degradation of noxious substances in stressed environs -- Bioremediation: A viable approach for degradation of petroleum hydrocarbon -- Application of macrophytes for remediation of wastewater in constructed wetlands -- Application of Biotechnology for restoration of degraded environs -- Role of Free Floating Aquatic Macrophytes in abatement of the disturbed Environs -- Genetically Modified Microbes as Biofertilizers -- Nanotechnology: A Modern Waste management approach -- Restoration of Heavy Metal Contaminated Environs through Ectomycorrhizal Symbiosis -- Index.
    Abstract: The rapid thriving of industries, conversion of agricultural land to residential areas, habitat destruction, deforestation and use of recalcitrant synthetic substances enhanced the rate of degradation of the environment. Although there are various conventional techniques for degradation and cleaning of noxious pollutants from disturbed environs, they are energy inefficient and costly to install. Bioremediation has emerged recently as an alternative and novel approach to manage and control environmental pollutants. This volume focuses explicitly on the remediation of noxious substances in stressed environs. It includes expert-contributed chapters on bio-monitoring by way of evaluating the relationship of biota with the polluted/stressed environs, sustainable plant-based degradation of noxious pollutants, and the application of biotechnologies to achieve tailored responses. Academicians, researchers, scientists and students will find this work essential for sustainable treatment of noxious pollutants. This book also serves as a core guide for training, teaching and research in conservation biology and environmental rehabilitation.
    Type of Medium: Online Resource
    Pages: XX, 340 p. 41 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030486907
    DDC: 333.9516
    Language: English
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  • 24
    Keywords: Biodiversity. ; Agriculture. ; Forestry. ; Plant biotechnology. ; Plant diseases. ; Energy policy. ; Energy and state. ; Biodiversity. ; Agriculture. ; Forestry. ; Plant Biotechnology. ; Plant Pathology. ; Energy Policy, Economics and Management.
    Description / Table of Contents: Genetically modified organisms (GMOs) impact and current status in Latin America: technological sovereignty or dependence? -- New biotechnology promising approaches for disease control on bananas and plantains -- Complementation of bananas conventional breeding programs through biotechnological genetic improvement -- The stress as inducer of heritable changes in micropropagated banana: the hypothesis of cytokinin accumulation -- Somatic embryogenesis for clonal propagation and associated molecular studies in cacao (Theobroma cacao L.) -- Use of biotechnology in Forestry breeding programs for natural resources and biodiversity conservation; Creating super trees for the future -- Stress modulation in Pinus spp. Somatic embryogenesis as model for climate change mitigation; Stress is not always a problem -- A Protective Role for Accumulated Dry Matter Reserves in Seeds During Desiccation: Implications for Conservation -- Biodiversity in Ecuador and its immense potential for agricultural pest control -- Native biodiversity: a strategic resource to accelerate bioeconomy development in Latin America and the Caribbean -- Low cost crop waste biosorbent technology for removing toxic and pollutants from wastewater -- The status of plant and plant-microbe interactions related to medicinal agents -- Bringing new function to packaging materials by agricultural byproducts -- Use of banana crop wastes to develop products in the aquaculture and plastic sectors -- Use of agroindustrial biomass for biofuels, enzymes discovery and production -- Temperature Profiles during the Fermentation of Cacao ‘Nacional’ to understand chocolate quality -- Ethno Phytopharmacology. Product validation process based on traditional knowledge of medicinal plants -- Biological control as a key tool for the management of invasive species in Latin America and the Caribbean -- Current research on Andean fruit crop diseases -- Biotechnological tools for the development of Foc TR4-resistant or tolerant Musa spp. Cultivars -- Integrated pest management of whitefly crop-free periods can reduce the Begomovirus transmission in tomato.
    Abstract: Food security, crop protection, biodiversity, and human and environmental health are among the main needs and concerns of society. Modern biotechnology and life sciences represent a constantly evolving area that is key for the rational use of natural resources – resources that in turn are indispensable for societal development. This book features the outcomes of the IV International Biotechnology and Biodiversity Congress, held in Guayaquil, Ecuador, 2018. It includes extensive reviews of the trends in agricultural and forestry biotechnology, molecules and materials biodiscovery, ethnomedicine, environmental impact and bioindustry research, describing many of these topics from the Latin America perspective and showing how the biodiversity and ancient knowledge of these countries are vital for worldwide sustainable development. .
    Type of Medium: Online Resource
    Pages: XIX, 460 p. 82 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030513580
    DDC: 333.95
    Language: English
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  • 25
    Keywords: Neurosciences. ; Otorhinolaryngology. ; Neuroscience. ; Otorhinolaryngology.
    Description / Table of Contents: Ch 1: Listening to All Voices: Interdisciplinary Approaches to Understanding Hearing in Aging -- Ch 2: Genetic and Molecular Aspects of the Aging Auditory System -- Ch 3: The Aging Cochlea and Auditory Nerve -- Ch 4: Age-Related Changes in the Auditory Brainstem and Inferior Colliculus -- Ch 5: Age related changes in the primate auditory cortex -- Ch 6: The Aging Auditory System: Electrophysiology -- Ch 7: Age-Related Changes in Segregation of Sound Sources -- Ch 8: Causes and Consequences of Age-Related Hearing Loss -- Ch 9: Age-Related Changes in Speech Understanding: Peripheral versus Cognitive Influences -- Ch 10: Aging, Hearing Loss, and Listening Effort: Imaging Studies of the Aging Listener -- Ch 11: Functional Consequences of Impaired Hearing in Older Adults and Implications for Intervention -- Ch 12: Emerging Clinical Translational Treatment Strategies for Age-Related Hearing Loss.
    Abstract: This volume provides contemporary discussions on new developments in aging research. It serves as an important update on the current state of research on the aging auditory system. Listening to All Voices: Interdisciplinary Approaches to Understanding Hearing in Aging Karen S. Helfer and Edward L. Bartlett Genetic and Molecular Aspects of the Aging Auditory System Shinichi Someya and Mi-Jung Kim The Aging Cochlea and Auditory Nerve Kevin K. Ohlemiller and Christopher Spankovich Age-Related Changes in the Auditory Brainstem and Inferior Colliculus Josef Syka Age-Related Changes in the Primate Auditory Cortex Gregg Recanzone The Aging Auditory System: Electrophysiology Kelly C. Harris Age-Related Changes in Segregation of Sound Sources Frederick J. Gallun and Virginia Best Causes and Consequences of Age-Related Hearing Loss Jennifer A. Deal, Nicholas S. Reed, Emily C. Pedersen, and Frank R. Lin Age-Related Changes in Speech Understanding: Peripheral versus Cognitive Influences Sandra Gordon-Salant, Maureen J. Shader, and Arthur Wingfield Aging, Hearing Loss, and Listening Effort: Imaging Studies of the Aging Listener Stefanie E. Kuchinsky and Kenneth I. Vaden, Jr. Functional Consequences of Impaired Hearing in Older Adults and Implications for Intervention Larry E. Humes, M. Kathleen Pichora-Fuller, and Louise Hickson Emerging Clinical Translational Treatment Strategies for Age-Related Hearing Loss Robert D. Frisina, Carlos J. Cruz, Tanika T. Williamson, Xiaoxia Zhu, and Bo Ding .
    Type of Medium: Online Resource
    Pages: XVII, 323 p. 62 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030493677
    Series Statement: Springer Handbook of Auditory Research, 72
    DDC: 612.8
    Language: English
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  • 26
    Keywords: Paleoecology. ; Paleontology . ; Bioinformatics. ; Archaeology. ; Earth sciences. ; Paleoecology. ; Paleontology. ; Computational and Systems Biology. ; Archaeology. ; Earth Sciences.
    Description / Table of Contents: Chapter 1-Introduction -- Chapter 2-Historical perspective -- Chapter 3-Geology and stratigraphy -- Chapter 4-Indian late cretaceous dinosaur nesting sites -- Chapter 5-Discussion. Chapter -- 6-Summary and conclusions.
    Abstract: This book documents analyses of the Late Cretaceous dinosaur nesting sites of the Lameta Formation at Jabalpur, Districts Dhar and Jhabua, Madhya Pradesh; Districts Kheda and Panchmahal (Gujarat); and the Pisdura, Dongargaon and Pavna sectors in the Chandrapur Districts of Maharashtra, which are exposed in India along an east-west and central axis. In this work, special emphasis has been given to the dinosaur nesting sites of the east-central Narbada River region, including its regional geology. The work was undertaken to provide detailed information concerning dinosaur eggs, eggshell fragments, nests and clutches found in the Lameta Formation of peninsular India. Prior to the present work there had been no detailed review of systematic work on the taxonomy, and of micro- and ultrastructural studies of dinosaur eggs and eggshells from the Lameta Formation. The study documents the field and laboratory investigations that facilitated the reconstruction of the morphotaxonomy, models for the burial pattern of eggs and eggshells, taphonomic implications,and the palaeoenvironmental context and palaeoecological conditions during the Late Cretaceous at the time of the extrusion of the Deccan traps, which may have been partly responsible for the extinction of the dinosaurs. The need to follow a parataxonomic classification for Indian dinosaur eggs and eggshell types is very apparent, and this book addresses this aspect in some detail. The emphasis on the application of parataxonomic schemes is based on the description of new oospecies and their comparison with previously known forms. The present work has led to the recovery of numerous nests, many collapsed eggs and hundreds of dinosaur eggshell fragments from the localities situated near the east, west and central Narbada River regions. It will be of interest to academics and professional palaeontologists, and all students of dinosaurs.
    Type of Medium: Online Resource
    Pages: XX, 280 p. 92 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030564544
    Series Statement: Topics in Geobiology ; 51
    DDC: 560.45
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant diseases. ; Agriculture. ; Conservation biology. ; Ecology . ; Plant Pathology. ; Agriculture. ; Conservation Biology.
    Description / Table of Contents: I. Biology of Plant defence -- 1.Plant defense in biological pest control -- 2. Specialized metabolites and plant defence -- 3.Sources of variation in defensive traits in Quercus species -- 4.Glycans as Modulators of Plant Defense -- 5.Biological Control and Need of a Strategic Shift -- II. Use of natural compounds -- 6.Polyphenolic Compounds Obtained from OMWW -- 7.small molecules of natural origin -- 8.Pinus polyphenols and antifungal activities -- 9.stilbenoid-enriched grape cane extracts in biocontrol -- III. Use of biological agents -- 10.Biological control of postharvest diseases -- 11.Sorghum allelopathy for sustainable weed management -- 12.Chaetomium as biocontrol agent on plant pathogens -- 13.Fusaria strains as biocontrol agents -- 14. Fungi as biological control -parasitic nematodes -- 15.Control of pepper powdery mildew -- 16.Molecular Mechanisms of Nematode- Microbe Interactions -- VI. Market and commercialization -- 17.Trends for commercialization of Biocontrol Agent.
    Abstract: Insects, pests and weeds are responsible for substantial loss of crops and reduced food supplies, poorer quality of agricultural products, economic hardship for growers and processor. Generally, chemical control methods are neither always economical nor are they effective and may have associated unwanted health, safety and environmental risks. Biological control involves use of beneficial biological agents to control pests and offers an environmental friendly approach to the effective management of plant diseases and weeds. The chapters are written by well recognized group leaders in the field. This book provides a comprehensive account of interaction of host and pests, and development of biological control agents for practical applications in crops management utilizing inherent defence mechanism, induced stimulation and biological control agents. The contents are divided into the following sections: General biology of plant defence, Use of natural compounds for biological control, Use of biological agents, Mechanism of action and Commercial aspects. The book will be useful for academicians, researcher and industries involved in study and manufacturing these products.
    Type of Medium: Online Resource
    Pages: X, 478 p. 72 illus., 54 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030510343
    Series Statement: Progress in Biological Control, 22
    DDC: 571.92
    Language: English
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  • 28
    Keywords: Medical microbiology. ; Diseases. ; Microbiology. ; Medical Microbiology. ; Diseases. ; Microbiology.
    Description / Table of Contents: Chapter 1: The INFECT-project: An international multidisciplinary project on necrotizing soft tissue infections -- Chapter 2: Necrotizing Soft Tissue Infections: case reports from the patients prospective -- Chapter 3: Necrotizing soft tissue infections: Case-reports, from the clinician’s perspectives -- Chapter 4: Necrotizing soft tissue infections: clinical features and diagnostic aspects -- Chapter 5: Microbiological etiology of necrotizing soft tissue infections -- Chapter 6: Beta-hemolytic streptococci and necrotizing soft tissue infections -- Chapter 7: Treatment of necrotizing soft tissue infections: Antibiotics -- Chapter 8: Treatment of necrotizing soft tissue infections: IVIG -- Chapter 9: Pathogenic mechanisms of streptococcal necrotizing soft tissue infections -- Chapter 10: Systems genetics approaches in mouse models of Group A Streptococcal necrotizing soft tissue infections -- Chapter 11: Systems biology and biomarkers in necrotizing soft tissue infections -- Chapter 12: Systems and precision medicine in necrotizing soft tissue infections.
    Abstract: This volume aims to enhance the current understanding of clinical features, treatment and pathogenic aspects in necrotizing soft tissue infections. Various representative case studies are discussed to enhance the readers’ understanding of these complex diseases. Necrotizing soft tissue infections are rapidly spreading infections that may cause extensive soft tissue or limb loss, multiorgan failure and are associated with a considerable fatality rate. It is undisputed that rapid diagnosis and prompt intervention is directly related to survival. The initial presentation may be limited to unspecific symptoms such as tenderness, swelling, erythema and pain. Thus, diagnosis and management are challenging due to heterogeneity in clinical presentation, in co-morbidities, in microbiological aetiology, as well as in the pathogenic mechanisms. An international and multidisciplinary consortium, INFECT, has for the last 6 years been pursuing research aimed to advance the understanding of the clinical and pathogenic aspects of these infections. A central part has been to create a comprehensive clinical registry and associated biobank which have also formed the basis for the experimental studies. Using the INFECT patient cohort, as well as an integrated systems biology approach in patients and clinically relevant experimental models, an advanced insight of diagnostic features, causative microbial agents, treatment strategies, and pathogenic mechanisms (host and bacterial disease traits and their underlying interaction network) has been obtained.
    Type of Medium: Online Resource
    Pages: VIII, 207 p. 60 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030576165
    Series Statement: Advances in Experimental Medicine and Biology, 1294
    DDC: 616.9041
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biomaterials. ; Nucleic acids. ; Bioinformatics. ; Biology Technique. ; Nucleic Acid. ; Computational and Systems Biology. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Strategies in Life sciences -- Chapter 2. Management and Manufacturing process of biologics -- Chapter 3. Downstream processes -- Chapter 4. Bioprinting -- Chapter 5. Biopharmaceuticals: New Frontier.
    Abstract: Tailoring of biomolecules using protein engineering technology, and host cells culture techniques are among the most sophisticated and elegant achievements of modern applied life sciences in which the basic fundamentals biotechnology are applicable for the development and manufacturing of biologics and other related bio-molecules for a hurdle free life with good health. A majority of biologics derived from genetically modified host cells in the current market are bio-formulation such as antibodies, nucleic acid products and vaccines. Such bio-formulations are developed mainly in two steps i.e. upstream process and downstream process. The first volume of this series begins with the latest information on how the classical stepwise host cells culture (mammals, animals, plants, and bacteria) methodology has been changed to fully continuous or partially continuous host cells culture process in order to economise the biopharmaceutical products manufacturing process. In addition this volume narrates a brief history on conceptual development of new thoughts in designing biotechnology industries for commercial production of variety of therapeutic proteins with structural modification on the basis of clinical requirements. The readers will feel exited by going through the latest discovery and development in applied life sciences for designing innovative biomolecules for health care with utmost safe. The most interesting part of this volume is newly developed concept on bioprinting. It explains how to design and fabricate animate objects by fusing or depositing material of interest in the form of powders, solid dusts, metal, liquid or even living cells or tissues by layers to produce 3D objectives. The first volume ends with the latest information on the current trend in biologics market, market dynamic, drives, and opportunities with challenges.
    Type of Medium: Online Resource
    Pages: XV, 189 p. 84 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811575907
    Series Statement: New Paradigms of Living Systems, 1
    DDC: 620.19
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: MicroRNAs in the tumor microenvironment -- The Impact of Estrogen in the Tumor Microenvironment -- The non-bone related role of RANK/RANKL signaling in cancer -- Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment -- Exosomes: Novel Players of Therapy Resistance in Neuroblastoma -- COX-2 Signaling in the Tumor Microenvironment -- Renin–angiotensin system in the tumor microenvironment -- Stem cell secreted factors in the tumor microenvironment -- Tight interplay between therapeutic monoclonal antibodies and the tumor microenvironment in cancer therapy -- Tumor Microenvironment & Nitric Oxide: Concepts and Mechanisms -- Index.
    Abstract: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIV, 162 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030502249
    Series Statement: Advances in Experimental Medicine and Biology, 1277
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Conservation biology. ; Ecology . ; Agriculture. ; Environmental health. ; Botany. ; Landscape ecology. ; Conservation Biology. ; Agriculture. ; Environmental Health. ; Plant Science. ; Landscape Ecology.
    Description / Table of Contents: Chapter1. Taming the Land, A Historical Perspective -- Chapter2. The Ecological Connection in Farming, Ranching, and Gardening -- Chapter3. Hydrology and Erosion Processes -- Chapter4. Cover Crop Dynamics on Hydrology and Erosion -- Chapter5. Vegetation Effects on Hydrology and Erosion: Grazinglands -- Chapter6. Organic Matter: The Whole Truth and Nothing but the Truth -- Chapter7. Soil-Hydrology-Plant Assessment Technologies for Cropland, Rangeland, Pastureland, and Gardens.
    Abstract: This book explores the importance of soil health in croplands, rangelands, pasturelands, and gardens, and presents new methods and technologies for assessing soil dynamics and health in these different land types. Through perspectives of agriculture, soil management, and ecological sustainability, the book provides accurate and up-to-date information on soil health assessment and maintenance that is often missing from current literature on conservation and environmental management and preservation. The book is written in a clear and concise format, and will appeal to non-scientists interested in soil health, as well as professional farmers, ranchers and gardeners. The book begins by discussing soil health from a historical perspective, and in terms of how it is covered in the news currently. Then the author addresses the ecological implications of soil health in farming, ranching and gardening, and comprehensively details the physical, chemical and biological properties of soil as they apply in various land types. The book then examines soil health assessment using new diagnostic and analytic technologies, and how these new innovations will be necessary going forward to maintain and improve soil health. .
    Type of Medium: Online Resource
    Pages: IX, 370 p. 119 illus., 69 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030403980
    DDC: 333.9516
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Biochemical markers. ; Immunotherapy. ; Cancers. ; Biomarkers. ; Immunotherapy.
    Description / Table of Contents: 1 Tumor heterogeneity: challenges and perspectives for gastrointestinal cancer therapy -- 2 immune composition of gastrointestinal tract of Gut -- 3 Immunomarkers for detection of GI malignancies -- 4 Immuno-therapeutics of gastrointestinal malignancies -- 5 Immune cell therapy against gastrointestinal tract cancers -- 6 Immune checkpoint inhibitors in gastrointestinal malignancies -- 7 Monoclonal Antibody therapy against gastrointestinal tract cancers -- 8 Therapeutic Vaccines for Gastrointestinal Malignancies -- 9 Immuno-Oncology of Oesophageal Cancer -- 10 Association between IL6 gene polymorphisms and gastric cancer risk: A meta-analysis of case-control studies -- 11 Immuno-oncology of colorectal cancer -- 12 Immune targets in colorectal cancer -- 13 Applications of computational biology in gastrointestinal malignancies. .
    Abstract: This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies. .
    Type of Medium: Online Resource
    Pages: XII, 251 p. 34 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811564871
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    DDC: 571.978
    Language: English
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  • 33
    Keywords: Microbiology. ; Biotechnology. ; Refuse and refuse disposal. ; Microbiology. ; Biotechnology. ; Waste Management/Waste Technology.
    Description / Table of Contents: Part 1 Introductory Chapters -- 1 Emerging Frontiers of Microbes as Agro-waste Recycler -- 2 Microbes: the next generation bioenergy producers -- 3 Emerging and eco-friendly approaches for waste management -- 4 Ecofriendly microbial biofuel production from waste -- 5 Bioremediation: Current research trends and applications -- 6 Bioremediation: an approach for environmental pollutants detoxification -- 7 Bioethanol extraction and its production from agricultural residues for sustainable development -- Part 2 Biotechnological approaches -- 8 Byproduct valorization of vegetable oil industry through biotechnological approach -- 9 Omics tools: Approaches for microbiomes analysis to enhance bioenergy production -- 10 Omics (genomics, proteomics, metabolomics etc.) tools to study the environmental microbiome and Bioremediation -- Part 3 Industrial waste management -- 11 Microalgae: Omics approaches for biofuel production and biomedical research -- 12 Waste Utilization and Minimization in Food Industry.-13 Ligninolytic microbes and their role in effluent management of pulp and paper industry -- 14 Production of Polyhydroxyalkanoates using waste as raw materials. 15 Newer Aspects of Waste-to-Valorisation Technologies in Food Industry -- 16 Xylanase in waste management and its industrial applications -- 17 Organic Acid Production from Agricultural Waste. .
    Abstract: This book addresses waste generation problems from various sectors, including industries, agriculture, and household. It focuses on how modern biotechnological approaches could help manage waste in an eco-friendly manner and generate precious bioenergy. It discusses the inadequate waste management systems damaging the environment and its adverse impacts on climate change-related problems. This book covers all the essential information regarding various types of waste and their management. It is a comprehensive compilation for understanding the efficient generation of bioenergy. It is a relevant reading material (resource) for anyone who wishes to study waste management as Chemist, Biologist, Biotechnologist, Industrialist, Ecologist, Microbiologist, Economist, and all disciplines related to the environment.
    Type of Medium: Online Resource
    Pages: VIII, 438 p. 60 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813343474
    DDC: 579
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Food Microbiology. ; Food science. ; Food Microbiology. ; Food Science.
    Description / Table of Contents: Chapter One Why encapsulate antioxidants in emulsion-based systems, where they are located, and how location affects their efficiency -- Chapter Two High-energy emulsification methods for encapsulation of lipid-soluble antioxidants -- Chapter Three Low-energy emulsification methods for encapsulation of antioxidants -- Chapter Four Nanoemulsions as carriers for natural antioxidants: formulation development and optimization -- Chapter Five Microemulsions as antioxidant carriers -- Chapter Six Membrane emulsification for encapsulation of bioactives: Application to the encapsulation of antioxidants -- Chapter Seven Encapsulation of antioxidants using double emulsions -- Chapter Eight Stability and release behavior of bioactive compounds (with antioxidant activity) encapsulated by Pickering emulsion -- Chapter Nine Advances in the oxidative stability mechanisms of emulsions -- Chapter Ten The role of antioxidants and encapsulation processes in omega-3 stabilization -- Chapter Eleven Encapsulation of pigmented lipophilic antioxidants through micro and nanoemulsions -- Chapter Twelve Characterization techniques for emulsion-based antioxidant carriers with biomedical applications.
    Abstract: The limited aqueous solubility of bioactive pharmaceutical ingredients presents a tremendous challenge in the development of new drugs. In recent years, methods have been developed to protect these sensitive bioactive compounds, namely antioxidants, with the aim of increasing the public sanitation grades. Emulsion-based systems are particularly interesting as colloidal delivery encapsulation systems, because they can easily be created from food-grade ingredients using relatively simple processing protocols. It is one of the most favorable delivery systems to increase the solubility of phytochemicals, nutraceuticals and food additives. Emulsion‐based Encapsulation of Antioxidants: Design and Performance advances the field of colloid science through the investigation of the effects of formulation and process parameters that influence emulsion production. The book offers a deeper comprehension of the technological and biological aspects of the incorporation of encapsulated compounds in food matrices and explication of their activity. Chapters provide an overview of the status of emulsion-based formulations to encapsulate antioxidants, fabrication, properties, applications, and biological fate with emphasis on systems suitable for utilization within industry. Special emphasis is placed on the antioxidant activity of the carriers being the key advantage of these emulsion-based systems. The main aim of the book is to inspire and to guide fellow scientists and students in this field. Filled with illustrations, figures, case studies, practical examples, and historical perspectives, the book can also be used as a practical handbook or graduate textbook. For industry professionals, the book presents easy-to-achieve approaches to industrial pharmaceutical production. .
    Type of Medium: Online Resource
    Pages: XIII, 473 p. 96 illus., 75 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030620523
    Series Statement: Food Bioactive Ingredients,
    DDC: 664.001579
    Language: English
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    Keywords: Pharmacology. ; Immunology. ; Pharmacology. ; Immunology.
    Description / Table of Contents: Preface Chapter 1: Overview of the Immune System and its Pharmacological Targets -- Chapter 2: Modulation of the Innate Immune System -- Chapter 3: Modulation of the Adaptive Immune System -- Chapter 4: Respiratory Disorders of the Immune System and their Pharmacological Treatment -- Chapter 5: Inflammation of the Skin and its therapeutic topics -- Chapter 6: Inflammatory Diseases of the Gastrointestinal Tract and Pharmacological Treatments -- Chapter 7: Mechanisms of Autoimmunity and Pharmacologic Treatments -- Chapter 8: Transplantation: Immunologic Principles and Pharmacologic Agents -- Chapter 9: Immunopathogenesis, Immunization, and Treatment of Infectious Diseases -- Chapter 10: Cancer Immunotherapy.
    Abstract: Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are discussed in detail. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.” Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.
    Type of Medium: Online Resource
    Pages: XIX, 399 p. 118 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030199227
    DDC: 615
    Language: English
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  • 36
    Keywords: Biodiversity. ; Water. ; Hydrology. ; Freshwater ecology. ; Marine ecology. ; Biotic communities. ; Animal culture. ; Science Study and teaching. ; Biodiversity. ; Water. ; Freshwater and Marine Ecology. ; Ecosystems. ; Animal Science. ; Science Education.
    Description / Table of Contents: 1. Science for the Future: The Use of Citizen Science in Marine Research and Conservation -- 2. A Literature Review on Stakeholder Participation in Coastal and Marine Fisheries -- 3. Law and Policy Dimensions of Ocean Governance -- 4. Status and Threats to Marine Biodiversity in the Anthropocene -- 5. Challenges in Marine Restoration Ecology: How Techniques, Assessment Metrics and Ecosystem Valuation can lead to Improved Restoration Success -- 6. Understanding how Microplastics Affect Marine Biota on the Cellular Level is Important for Assessing Ecosystem Function – A Review -- 7. Chemical Biodiversity and Bioactivities of Saponins in Echinodermata with an Emphasis on Sea Cucumbers (Holothuroidea) -- 8. Secondary Metabolites of Marine Microbes: From Natural Products Chemistry to Chemical Ecology -- 9. Sponges Revealed: A Synthesis of their Overlooked Ecological Functions within Aquatic Ecosystems -- 10. Theories, Vectors, and Computer Models – Marine Invasion Science in the Anthropocene -- 11. Benthos-Pelagos Interconnectivity: Antarctic Shelf Examples -- 12. Investigating the Land-Sea Transition Zone -- 13. Fisheries and Tourism: Social, Economic and Ecological Trade-offs in Coral Reef Systems -- 14. Progress in Microbial Ecology in Ice Covered Seas -- 15. Complex Interactions Between Aquatic Organisms and Their Chemical Environment Elucidated from Different Perspectives.
    Abstract: This open access book summarizes peer-reviewed articles and the abstracts of oral and poster presentations given during the YOUMARES 9 conference which took place in Oldenburg, Germany, in September 2018. The aims of this book are to summarize state-of-the-art knowledge in marine sciences and to inspire scientists of all career stages in the development of further research. These conferences are organized by and for young marine researchers. Qualified early-career researchers, who moderated topical sessions during the conference, contributed literature reviews on specific topics within their research field. .
    Type of Medium: Online Resource
    Pages: XIX, 370 p. 78 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030203894
    DDC: 333.95
    Language: English
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    Keywords: Agriculture. ; Nutrition   . ; Plant biotechnology. ; Food science. ; Agriculture Economic aspects. ; Agriculture. ; Nutrition. ; Plant Biotechnology. ; Food Science. ; Agricultural Economics.
    Description / Table of Contents: Preface -- Global Food Security, Contributions from Sustainable Potato Agri-Food Systems -- The Potato and its Contribution to the Human Diet -- Enhancing Value Chains through Collective Actions: Lessons From the Andes, Africa and Asia -- Ex situ Conservation of Potato [Solanum Section Petota (Solanaceae)] Genetic Resources in Genebanks -- The Genes and Genomes of the Potato -- Potato Breeding -- Genetics and Cytogenetics of Potato -- Insect Pests Affecting Potatoes in Tropical, Subtropical and Temperate Regions -- Fungal, Oomycete and Plasmodiophorid Diseases of Potato -- Bacterial Diseases of Potato -- Viral Diseases in Potato -- Potato Seed Systems -- Participatory Research (PR) at CIP with Potato Farming Systems in the Andes: Evolution and Prospects -- Gender Topics on Potato Research and Development -- Index. .
    Abstract: This book is open access under a CC BY 4.0 license. This book provides a fresh, updated and science-based perspective on the current status and prospects of the diverse array of topics related to the potato, and was written by distinguished scientists with hands-on global experience in research aspects related to potato. The potato is the third most important global food crop in terms of consumption. Being the only vegetatively propagated species among the world’s main five staple crops creates both issues and opportunities for the potato: on the one hand, this constrains the speed of its geographic expansion and its options for international commercialization and distribution when compared with commodity crops such as maize, wheat or rice. On the other, it provides an effective insulation against speculation and unforeseen spikes in commodity prices, since the potato does not represent a good traded on global markets. These two factors highlight the underappreciated and underrated role of the potato as a dependable nutrition security crop, one that can mitigate turmoil in world food supply and demand and political instability in some developing countries. Increasingly, the global role of the potato has expanded from a profitable crop in developing countries to a crop providing income and nutrition security in developing ones. This book will appeal to academics and students of crop sciences, but also policy makers and other stakeholders involved in the potato and its contribution to humankind’s food security. .
    Type of Medium: Online Resource
    Pages: XVII, 518 p. 99 illus., 91 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030286835
    DDC: 630
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Microbiology. ; Biotechnology. ; Evolution (Biology). ; Biomaterials. ; Nucleic acids. ; Cytology. ; Microbiology. ; Biotechnology. ; Evolutionary Biology. ; Nucleic Acid. ; Cell Biology.
    Description / Table of Contents: Reduced and Minimal Cell Factories in Bioprocesses: Towards a Streamlined Chassis -- Construction of minimal genomes and synthetic cells -- Engineering reduced-genome strains of Pseudomonas putida for product valorization -- Genome-reduced Corynebacterium glutamicum fit for biotechnological applications -- Reduction of the Saccharomyces cerevisiae genome: challenges and perspectives -- The use of in silico genome-scale models for the rational design of minimal cells -- From minimal to minimized genomes: Functional design of microbial cell factories -- Resource allocation principles and minimal cell design.
    Abstract: This book provides a comprehensive overview of the design, generation and characterization of minimal cell systems. Written by leading experts, it presents an in-depth analysis of the current issues and challenges in the field, including recent advances in the generation and characterization of reduced-genome strains generated from model organisms with relevance in biotechnology, and basic research such as Escherichia coli, Corynebacterium glutamicum and yeast. It also discusses methodologies, such as bottom-up and top-down genome minimization strategies, as well as novel analytical and experimental approaches to characterize and generate minimal cells. Lastly, it presents the latest research related to minimal cells of serveral microorganisms, e.g. Bacillus subtilis. The design of biological systems for biotechnological purposes employs strategies aimed at optimizing specific tasks. This approach is based on enhancing certain biological functions while reducing other capacities that are not required or that could be detrimental to the desired objective. A highly optimized cell factory would be expected to have only the capacity for reproduction and for performing the expected task. Such a hypothetical organism would be considered a minimal cell. At present, numerous research groups in academia and industry are exploring the theoretical and practical implications of constructing and using minimal cells and are providing valuable fundamental insights into the characteristics of minimal genomes, leading to an understanding of the essential gene set. In addition, research in this field is providing valuable information on the physiology of minimal cells and their utilization as a biological chassis to which useful biotechnological functions can be added.
    Type of Medium: Online Resource
    Pages: VII, 230 p. 35 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030318970
    DDC: 579
    Language: English
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    Keywords: Genetics. ; Radiation dosimetry. ; Cancer. ; Radiology. ; Human physiology. ; Biophysics. ; Genetics and Genomics. ; Radiation Dosimetry and Protection . ; Cancer Biology. ; Radiology. ; Human Physiology. ; Biophysics.
    Description / Table of Contents: Part 1. The Environmental Pollution Caused by the Fukushima Daiichi Nuclear Power Plant (FNPP) Accident -- 1. Estimation of Dose Rate for the Large Japanese Field Mice (Apodemus speciosus) Distributed in the “Difficult-to-Return Zones” in Fukushima Prefecture -- 2. Impacts of the Fukushima Nuclear Accident on Fishery Products and Fishing Industry -- 3. Incorporation and Accumulation of Strontium-90 in the Hard Tissue of Animals and Their Relationship with Strontium-90 Pollution in the Environment -- Part 2. Radiation Exposure and Its Effects on Wild Organisms after the FNPP Accident -- 4. Radioactive Cesium Contamination of Arthropods and Earthworms after the FNPP accident -- 5. Delayed Recovery from Declines in the Population Densities and Species Richness of Intertidal Invertebrates near the Fukushima Daiichi Nuclear Power Plant -- 6. Mutations observed in mitochondrial DNA of salmon collected in Mano River, Fukushima Prefecture, Japan -- 7. Influence of the FNPP Accident on Coniferous Trees: A Review -- Part 3. Radiation Exposure and Its Effects on Livestock after the FNPP Accident -- 8. Analysis of Ovaries and Fertilities in Domestic Animals affected by the Fukushima Daiichi Nuclear Power Plant Accident -- 9. Transgenerational Effects on Calf Spermatogenesis and Metabolome Associated with Paternal Exposure to the FNPP Accident -- 10. The Effect of Radiation on the Immune System in Pigs Affected by the Fukushima Daiichi Nuclear Power Plant Accident -- 11. Assessment of DNA Damage Induction in Farm Animals after the Fukushima Daiichi Nuclear Power Plant Accident -- Part 4. Dose Evaluation in Association with the FNPP Accident -- 12. Preliminary Study on Electron Spin Resonance Dosimetry Using Affected Cattle’s Teeth due to the Fukushima Daiichi Nuclear Power Plant Accident -- 13. Estimation of External and Internal Exposure in Japanese Macaques after the Fukushima Daiichi Nuclear Power Plant Accident -- Part 5. New Perspectives Raised after the FNPP Accident -- 14. Properties of Radioactive Cs-bearing Particles Released by the Fukushima Daiichi Nuclear Power Plant Accident and Trace Element Analysis -- 15. Cellular Effects of Insoluble Particles Containing Radioactive Cesium -- 16. Preparation and Genome Analysis of Immortalized Cells Derived from Wild Macaques Affected by the Fukushima Daiichi Nuclear Power Plant Accident -- 17. Effects of Radioactive Cesium-containing Water on Mice -- Prt 6. Overview of the FNPP accident -- 18. Comparison of Radioactivity Release and Contamination from the Fukushima and Chernobyl Nuclear Power Plant Accidents -- 19. The Pale Grass Blue Butterfly as an Indicator for the Biological Effect of the Fukushima Daiichi Nuclear Power Plant Accident -- 20. What We Learned and are Learning from the Affected Animal Dose Assessment Project. .
    Abstract: This open access book summarizes the latest scientific findings regarding the biological effects of the Fukushima Daiichi Nuclear Power Plant (FNPP) accident in 2011. Various cases of changes in animals and organisms have been reported since the FNPP accident. However, it is often unknown whether they are actually due to radiation, since the dose or dose-rate are not necessarily associated with the changes observed. This book brings together the works of radiation biologists and ecologists to provide reliable radioecology data and gives insight into future radioprotection. The book examines the environmental pollution and radiation exposure, and contains valuable data from abandoned livestock in the ex-evacuation zone and from wild animals including invertebrates and vertebrates, aqueous and terrestrial animals, and plants that are subjected to long-term exposure in the area still affected by radiation. It also analyzes dose evaluation, and offers new perspectives gained from the accident, as well as an overview for future studies to promote radioprotection of humans and the ecosystem. Since the biological impact of radiation is influenced by various factors, it is difficult to scientifically define the effects of low-dose/low-dose-rate radiation. However, the detailed research data presented can be combined with the latest scientific and technological advances, such as artificial intelligence, to provide new insights in the future. This book is a unique and valuable resource for researchers, professionals and anyone interested in the impact of exposure to radiation or contamination with radioactive materials.
    Type of Medium: Online Resource
    Pages: XV, 264 p. 90 illus., 65 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811382185
    DDC: 576.5
    Language: English
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    Keywords: Microbial ecology. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Water. ; Hydrology. ; Sustainability. ; Biotic communities. ; Microbial Ecology. ; Environmental Engineering/Biotechnology. ; Water. ; Sustainability. ; Ecosystems.
    Description / Table of Contents: Preface -- Foreword -- 1. Concerns and Threats of Contamination on Aquatic Ecosystems -- 2. Effect of Pesticides on Fish Fauna: Threats, Challenges and Possible Remedies -- 3. Impact of Invasive Plants in Aquatic Ecosystems -- 4. Role of Modern Innovative Techniques for Assessing and Monitoring Environmental Pollution -- 5. Global Scenario of Remediation Techniques to Combat Environmental Pollution -- 6. Biopesticides: clean and viable technology for healthy environment -- 7. Inoculum addition in the presence of plant rhizosphere for petroleum polluted soil remediation -- 8. Vermicomposting: An Eco-friendly Approach for Recycling /Management of Organic Wastes -- 9. Bio-Fertilizers: Ecofriendly Approach for Plant and Soil Environment -- 10. Phytoremediation of heavy metals: an ecofriendly and sustainable approach -- 11. Credibility of in situ Phytoremediation for Restoration of Disturbed Environments -- 12. Role of White Willow (Salix alba L.) for Cleaning up the Toxic Metal Pollution -- 13. Mycoremediation: a Sustainable Tool for Abating Environmental Pollution -- 14. Microbial Biofilm Cell Systems for Remediation of Wastewaters -- 15. Pollution remediation by way of using genetically modified plants (GMP) -- Index.
    Abstract: Toxic substances threatens aquatic and terrestrial ecosystems and ultimately human health. The book is a thoughtful effort in bringing forth the role of biotechnology for bioremediation and restoration of the ecosystems degraded by toxic and heavy metal pollution. The introductory chapters of the book deal with the understanding of the issues concerned with the pollution caused by toxic elements and heavy metals and their impacts on the different ecosystems followed by the techniques involved in monitoring of the pollution. These techniques include use of bio-indicators as well as modern techniques for the assessment and monitoring of toxicants in the environment. Detailed chapters discussing the role of microbial biota, aquatic plants, terrestrial plants to enhance the accumulation efficiency of these toxic and heavy metals are followed by remediation techniques involving myco-remediation, bio-pesticides, bio-fertilizers, phyto-remediation and rhizo-filtration. A sizable portion of the book has been dedicated to the advanced bio-remediation techniques which are finding their way from the laboratory to the field for revival of the degraded ecosystems. These involve bio-films, micro-algae, genetically modified plants and filter feeders. Furthermore, the book is a detailed comprehensive account for the treatment technologies from unsustainable to sustainable. We believe academicians, researchers and students will find this book informative as a complete reference for biotechnological intervention for sustainable treatment of pollution.
    Type of Medium: Online Resource
    Pages: XVIII, 327 p. 47 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030356910
    DDC: 579.17
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant genetics. ; Plant biotechnology. ; Agriculture. ; Plant Genetics. ; Plant Biotechnology. ; Agriculture.
    Description / Table of Contents: Introduction -- Botanical descriptions -- Medicinal properties: bioactives and their actions -- Genetic resources and genetic diversity -- Cytogenetical analysis of bitter gourd genome -- Sex determination -- Tissue culture, genetic engineering & nanotechnology -- Classical genetics and traditional breeding -- Molecular linkage mapping: Map construction and mapping of genes/QTLs -- Genome sequence and its comparative study with other Cucurbitaceae genome -- Functional genomics: metabolomics, transcriptomics (including biochemical study of interaction with parasite) -- Future Prospects.
    Abstract: This book focusing on the bitter gourd genome is the first comprehensive compilation of knowledge on the botany, cytogenetical analysis, genetic resources and diversity, traditional breeding, tissue culture and genetic transformation, whole genome sequencing and comparative genomics in the Cucurbitaceae family. It discusses the biochemical profile of the bioactives present in this horticultural crop, used both as a vegetable and as a medicine, and also addresses sex determination in bitter gourd. Written by respected international experts, the book is useful to students, teachers and scientists in academia, as well as seed companies and pharmaceutical industries.
    Type of Medium: Online Resource
    Pages: XXI, 135 p. 25 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030150624
    Series Statement: Compendium of Plant Genomes,
    DDC: 581.35
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Nanotechnology. ; Microtechnology. ; Microelectromechanical systems. ; Genetics. ; Biotechnology. ; Nanotechnology. ; Microsystems and MEMS. ; Genetics and Genomics. ; Chemical Bioengineering.
    Description / Table of Contents: Introduction: DNA basics (a primer on DNA) -- Hiding and storing messages and data in DNA -- DNA as a nanoscale building material -- DNA machines and nanobots -- DNA-based nanoelectronics -- Concluding remarks.
    Abstract: This is the first book portraying to a wide readership many fields of DNA in the world of materials altogether in a single volume. The book provides underlying concepts and state-of-art developments in the emerging fields of DNA electronics, structural DNA nanotechnology, DNA computing and DNA data storage, DNA machines and nanorobots. Future possibilities of innovative DNA-based technologies, such as DNA cryptography, DNA identity tags, DNA nanostructures in biosensing and nanomedicine, as well as DNA-based nanoelectronics are all covered, too. This book is valuable for university students studying engineering and technology; biotech, nanotech, and medical device R&D managers, practitioners and investors; and IP analysts who would like to extend their background in advanced DNA technologies. It is nicely illustrated, which makes it very readable, and it conveys science and principles in a lively language to appeal to a broad audience, from professionals and academics to students and lay readers. Advance Praise for DNA Beyond Genes: “Most students of DNA, and lay readers as well, are interested in the absolutely essential role it plays in biology. However, the properties which make DNA the carrier of genetic information also make it an extraordinary material that can be used as the backbone for a wide variety of nanoengineering applications – these range from information storage and computation to molecular machines and devices to artfully designed logos and symbols. The perfect self-recognition of DNA sequences makes it an ideal building block to synthesize more and more elaborate constructions and imaginative scientists have probably only just scratched the surface of what can eventually be created. Here for the first time in this wonderful book Vadim Demidov explores the full range of the non-biological applications of DNA.” Charles R. Cantor Professor Emeritus of Biomedical Engineering, Boston University Member of the USA National Academy of Sciences.
    Type of Medium: Online Resource
    Pages: XX, 107 p. 66 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030364342
    DDC: 660.6
    Language: English
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    Keywords: Plants Development. ; Landscape ecology. ; Plants Evolution. ; Biodiversity. ; Plant physiology. ; Plant Development. ; Landscape Ecology. ; Plant Evolution. ; Biodiversity. ; Plant Physiology.
    Description / Table of Contents: Part 1.Cryopreservation and Biotechnology -- 1.Cryopreservation Development of some endangered Thai Orchid species -- 2.Status of Orchid Industry in India -- 3.Cryobiotechnological studies in Vanilla, the orchid of multi- industrial uses -- 4.In vitro propagation and germplasm conservation of wild orchids from South America -- 5.Postharvest Technology of cut-flowers of Orchids -- 6.Cryobiotechnology of Korean orchid biodiversity: a case study using Cymbidium kanra -- Part 2.Orchid Biodiversity and Conservation -- 7.Species diversity and distribution of Orchids in district Rudraprayag, Uttarakhand, North East Himalaya, India -- 8.Status of genetic diversity and its characterization in genus Bulbophyllum (Orchidaceae) from North-Eastern India -- 9.Orchid diversity in Darjeeling Himalaya, India: Present status and conservation -- 10.Orchid Diversity in the Eastern Ghats of Northern Andhra Pradesh, India -- 11.History and Scientific Potential of the Orchid Collection of the Stoсk Greenhouse of the Main Botanical Garden RAS (Moscow, Russia) -- 12.Status of Orchid Diversity, Conservation, Research and Development in Arunachal Pradesh – An Overview -- Part 3. Anatomy and Physiology -- 13.Orchid mycorrhizal fungi- structure, function, and diversity -- 14.Orchid Seed Ultra structure: Ecological and Taxonomic Implications with reference to Epidendroideae (Orchidaceae) -- 15.Structural Adaptations of Bulbophyllum and Dendrobium (Orchidaceae) to the Epiphytic Habitat and their Phylogenetic Implications -- 16.Physiological response of Dendrobium cv. Earsakul to plant growth promoters and growing systems -- 17.Anatomical studies in some Indian Coelogyneae (Orchidaceae)., Part 4. Pollination Biology -- 18.Beauty of Orchid Flowers: Are not adequate to lure Indian biologists? -- 19.Evolution of Organismal Female Wasp Mimics in Sexually Deceptive Orchid genus Chiloglottis (Orchidaceae) -- 20.Pollination studies in the genus Habenaria Willd. (Orchidaceae) from Western Ghats -- Part 5. Orchid Chemicals and Bioactive Compounds -- 21.Phytochemical analysis, antioxidant and anti-inflammatory activity of Eria tomentosa (Koen.) Hook. f -- 22.Medicinal orchids: production of bioactive compounds and biomass -- 23.Ethnomedicinal aspects of some Orchids from Darjeeling Himalaya, India -- 24.Evaluation of Phytoconstituents and Antibacterial activity of Vanda tessellata using in vitro model -- 25.Screening of Bioactive Phytochemicals in some Indigenous Epiphytic Orchids of Bangladesh -- 26.GC-MS analysis of organic extracts of Cymbidium aloifolium (L.) Sw. (Orchidaceae) leaves from Eastern Ghats of India -- 27.Anticancer property in Acampe praemorsa and Aerides odorata (Orchidaceae), an in vitro approach -- 28.Phytochemical Screening and Evaluation of Antimicrobial Potential of Dendrobium fimbriatum Hook.
    Abstract: This book on “Orchid Biology: Recent Trends & Challenges” reviews the latest strategies for the preservation and conservation of orchid diversity and orchid germplasm. It is an outcome of the Proceedings of the International Symposium on “Biodiversity of Medicinal Plants & Orchids: Emerging Trends and Challenges” held on 9-11 February 2018 at Acharya Nagarjuna University, India. In addition, eminent orchid experts from around the globe were invited to contribute to this book. All chapters were peer-reviewed by international experts. The Orchidaceae are one of the largest families of flowering plants, comprising over 700 genera and 22,500 species and contributing roughly 40 percent of monocotyledons. They also represent the second-largest flowering plant family in India, with 1,141 species in 166 genera, and contribute roughly 10% of Indian flora. Orchids comprise a unique group of plants and their flowers are among the most enchanting and exquisite creations of nature. Phylogenetically and taxonomically, the Orchidaceae are considered to be a highly evolved family among angiosperms. They show incredible diversity in terms of the shape, size and colour of their flowers, and are of great commercial importance in floriculture markets around the globe. Millions of cut flowers of Cymbidium, Dendrobium, Cattleya, Paphiopedilum, Phalaenopsis, Vanda etc., besides potted orchid plants, are sold in Western Countries and thus, the orchid cut flower industry has now become a multimillion-dollar business in Europe, the USA and South East Asia. Besides their ornamental value, orchids hold tremendous pharmaceutical potential. Root tubers of Habenaria edgeworthii form an important component of the ‘Astavarga’ group of drugs in Ayurvedic medicine. It is an established fact that tubers of some terrestrial orchids have been used to treat diarrhoea, dysentery, intestinal disorders, cough, cold and tuberculosis. Some orchids, particularly those belonging to the genera Aerides, Arachnis, Cattleya, Cymbidium, Dendrobium, Epidendrum, Oncidium, Paphiopedilum, Phalaenopsis, Renanthera, Vanda etc. have been extensively used to produce internationally acclaimed hybrids. Yet paradoxically, Indian orchids are victims of their own beauty and popularity. As a result, their natural populations have been declining rapidly because of unbridled commercial exploitation in India and abroad. In fact, some orchids are now at the verge of extinction, e.g. Renanthera imschootiana, Diplomeris hirsuta, Paphiopedilum fairrieanum, Cypripedium elegans, Taeniophylum andamanicum etc. Given the global importance of orchids in terms of securing human health and wealth, this comprehensive compilation, prepared by international experts, is highly topical. Its content is divided into five main sections: (I) Cryopreservation & Biotechnology, (II) Orchid Biodiversity & Conservation, (III) Anatomy & Physiology, (IV) Pollination Biology and (V) Orchid Chemicals & Bioactive Compounds. All contributions were written by eminent orchid experts/professors from around the world, making the book a valuable reference guide for all researchers, teachers, orchid enthusiasts, orchid growers and students of biotechnology, botany, pharmaceutical sciences and ethnomedicine. It will be equally valuable for readers from the horticultural industry, especially the orchid industry, agricultural scientists and policymakers.
    Type of Medium: Online Resource
    Pages: XVIII, 547 p. 133 illus., 113 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813294561
    DDC: 571.82
    Language: English
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    Keywords: Conservation biology. ; Ecology . ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Water. ; Hydrology. ; Sustainability. ; Applied ecology. ; Agriculture. ; Conservation Biology. ; Environmental Engineering/Biotechnology. ; Water. ; Sustainability. ; Applied Ecology. ; Agriculture.
    Description / Table of Contents: Preface -- 1. Causes and Effects of Pesticide and Metal Pollution on Different Ecosystems -- 2. Ecotoxicology of Heavy Metals: Sources, Effects and Toxicity -- 3. Role of Modern Innovative Techniques for Assessing and Monitoring Heavy Metal and Pesticide Pollution in Different Environments -- 4. Global Scenario of Remediation Techniques to Combat Pesticide Pollution -- 5. Mycoremediation: A Sustainable Approach for Pesticide Pollution Abatement -- 6. Bio-pesticides: Application and Possible Mechanism of Action -- 7. Values of Biofertilizers for Sustainable Management in Agricultural Industries -- 8.Role of Macrophytes in Spontaneous Lacustrine Phytofiltration -- 9. Phytoremediation of Heavy Metals Using Salix (Willows) -- 10. Photo catalysis: An Effective Tool for Treatment of Dyes Contaminated Wastewater -- 11. Removal of dyes from waste water by Micellar Enhanced Ultrafiltration -- 12. Biofilm: an innovative modern technology for aquatic pollution remediation -- 13. Heavy Metal Soil Contamination and Bioremediation -- 14. Environmental Biotechnology: For Sustainable Future -- 15. Global Environmental Regulations for Management of Pesticides -- Index.
    Abstract: This book addresses the grave concerns stemming out due to conventional treatment techniques. The main focus of this book revolves round the central kernel of novel technology (bioremediation and biotechnology) which has emerged as an independent warrior to clean up and restore the disturbed environs. Furthermore, this book is a coherent assortment of diverse chapters relevant to the role of biotechnology and bioremediation for restoration of the ecosystems degraded by pesticide and heavy metal pollution. The inaugural chapters deal with the quantification of problem and its magnitude due to pesticides and heavy metals, followed by innovative modern biotechnological and bioremediation treatment technologies and sustainable techniques to remediate the persistent pollutants. It is a detailed comprehensive account for the treatment technologies from unsustainable to sustainable. Academicians, researchers and students shall find it as a complete wrap up regarding biotechnological intervention for sustainable treatment of pollution and shall suffice for the diverse needs of teaching and research.
    Type of Medium: Online Resource
    Pages: XVI, 278 p. 38 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030403331
    DDC: 333.9516
    Language: English
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    Keywords: Bacteria. ; Biomaterials. ; Nucleic acids. ; Proteins. ; Medical microbiology. ; Bacteria. ; Nucleic Acid. ; Proteins. ; Medical Microbiology.
    Description / Table of Contents: Part I:Biochemistry/Structural Biology – Enzymes -- Chapter 1: Cyclic Dinucleotide Signaling In Mycobacteria -- Chapter 2: Structure and regulation of EAL domain proteins -- Chapter 3: Insights into the molecular basis of biofilm dispersal from crystal structures of di-domain containing proteins -- Chapter 4: Structure and function of HD-GYP phosphodiesterases -- Chapter 5: A unified catalytic mechanism for c-di-NMP hydrolysis by DHH/DHHA1 phosphodiesterases -- Chapter 6: Enzymatic degradation of linear dinucleotide intermediates of cyclic dinucleotides -- Part II:Biochemistry/Structural Biology – Receptors -- Chapter 7: Detection of cyclic dinucleotide binding proteins -- Chapter 8: Non-canonical c-di-GMP binding modes -- Part III:Biochemistry/Structural Biology – Sensing -- Chapter 9: Sensory domains that control cyclic di-GMP-modulating proteins: a critical frontier in bacterial signal transduction -- Part IV:Cyclic di-AMP biochemistry and physiology -- Chapter 10: Metabolic regulation by cyclic di-AMP signaling -- Chapter 11: Osmoregulation via cyclic-di-AMP signaling -- Part V:Population diversity -- Chapter 12: Measuring individual cell c-di-GMP: Identifying population diversity and c-di-GMP heterogeneity.-Part VI:Cyclic di-GMP and exopolysaccharide regulation -- Chapter 13: Activation of bacterial cellulose biosynthesis by cyclic-di-GMP -- Chapter 14: The Regulation of Alginate Biosynthesis viaC-di-GMPSignaling -- Part VII:Environmental bacteria -- Chapter 15: Cyclic di-GMP Signaling in Bacillus subtilis -- Chapter 16: C-di-GMP signaling systems in the Gram-positive Bacillus cereus group -- Chapter 17: Cyclic-di-AMP in Bacillus subtilisbiofilm formation.-Chapter 18: Regulation by c-di-GMP in Myxococcusxanthus -- Chapter 19: Light-regulated nucleotidesecond messenger signalingin cyanobacteria -- Chapter 20: C-di-GMP-dependent regulation of antibiotic biosynthesis in Lysobacter -- Chapter 21: Cyclic di-GMP signalingin extreme acidophilic bacteria -- Part VIII:Pathogens -- Chapter 22: Signals modulating cyclic di-GMP pathways in Vibrio cholera -- Chapter 23: Cyclic di-GMP regulation of gene expression -- Chapter 24: Cyclic di-GMP signaling in Salmonella enterica serovar Typhimurium -- Chapter 25: Cyclic di-GMP signaling in the phytopathogen Xanthomonas campestris pv. Campestris -- Chapter 26: Cyclic di-AMP in Mycobacterium tuberculosis -- Chapter 27: Cyclic di-AMP signaling in Streptococcus pneumonia -- Part IX:Gram-negative bacteria -- Chapter 28: Regulation of cyclic-di-GMP signaling in Pseudomonas aeruginosa -- Chapter 29: Unconventional Cyclic di-GMPSignalling in Escherichia coli -- Chapter 30: Cyclic di-GMP in Burkholderia spp -- Chapter 31: Cyclic di-GMP and the regulation of biofilm dispersion -- Part X:Cyclic di-GMP signaling in eukaryotes -- Chapter 32: Cyclic-di-GMP activates adenylate cyclase A and protein kinase A to induce stalk formationin Dictyostelium -- Part XI:Interference Strategies -- Chapter 33: Targeting cyclic di-nucleotide signaling with small molecules -- Part XII:Novel cyclic di-nucleotides -- Chapter 34: Cyclic di-GMP signaling gone astray: cGAMP signaling via Hypr GGDEF and HD-GYP enzymes -- Chapter 35: Microbial cyclic GMP-AMP signaling pathways.-Part XIII:Honorary cyclic nucleotides -- Chapter 36: 2’,3’-cyclic mononucleotide metabolism and possible roles in bacterial physiology -- Part XIV:Horizontal gene transfer -- Chapter 37: Horizontal transfer of c-di-GMP associated genes. Theoretical underpinnings and future perspectives.-Part XV:Conclusion -- Chapter 38: Conclusion. .
    Abstract: This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described. In turn, the various aspects of bacterial physiology affected by these signaling systems– e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis – are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior. Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions.
    Type of Medium: Online Resource
    Pages: XVIII, 657 p. 108 illus., 96 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030333089
    DDC: 579.3
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical sciences. ; Statistics . ; Social sciences. ; Humanities. ; Biomedical Research. ; Health Sciences. ; Statistics. ; Humanities and Social Sciences.
    Description / Table of Contents: Preface -- Section I Cluster and Classification Models -- Hierarchical Clustering and K-means Clustering to Identify Subgroups in Surveys (50 Patients) -- Density-based Clustering to Identify Outlier Groups in Otherwise Homogeneous Data (50 Patients) -- Two Step Clustering to Identify Subgroups and Predict Subgroup Memberships in Individual Future Patients (120 Patients) -- Nearest Neighbors for Classifying New Medicines (2 New and 25 Old Opioids) -- Predicting High-Risk-Bin Memberships (1445 Families) -- Predicting Outlier Memberships (2000 Patients) -- Data Mining for Visualization of Health Processes (150 Patients) -- Trained Decision Trees for a More Meaningful Accuracy (150 Patients) -- Typology of Medical Data (51 Patients) -- Predictions from Nominal Clinical Data (450 Patients) -- Predictions from Ordinal Clinical Data (450 Patients) -- Assessing Relative Health Risks (3000 Subjects) -- Measurement Agreements (30 Patients) -- Column Proportions for Testing Differences between Outcome Scores (450 Patients) -- Pivoting Trays and Tables for Improved Analysis of Multidimensional Data (450 Patients) -- Online Analytical Procedure Cubes for a More Rapid Approach to Analyzing Frequencies (450 Patients) -- Restructure Data Wizard for Data Classified the Wrong Way (20 Patients) -- Control Charts for Quality Control of Medicines (164 Tablet Desintegration Times) -- Section II (Log) Linear Models -- Linear, Logistic, and Cox Regression for Outcome Prediction with Unpaired Data (20, 55, and 60 Patients) -- Generalized Linear Models for Outcome Prediction with Paired Data (100 Patients and 139 Physicians) -- Generalized Linear Models for Predicting Event-Rates (50 Patients) -- Factor Analysis and Partial Least Squares (PLS) for Complex-Data Reduction (250 Patients) -- Optimal Scaling of High-sensitivity Analysis of Health Predictors (250 Patients) -- Discriminant Analysis for Making a Diagnosis from Multiple Outcomes (45 Patients) -- Weighted Least Squares for Adjusting Efficacy Data with Inconsistent Spread (78 Patients) -- Partial Correlations for Removing Interaction Effects from Efficacy Data (64 Patients) -- Canonical Regression for Overall Statistics of Multivariate Data (250 Patients) -- Multinomial Regression for Outcome Categories (55 Patients) -- Various Methods for Analyzing Predictor Categories (60 and 30 Patients) -- Random Intercept Models for Both Outcome and Predictor Categories (55 Patients) -- Automatic Regression for Maximizing Linear Relationships (55 Patients) -- Simulation Models for Varying Predictors (9000 Patients) -- Generalized Linear Mixed Models for Outcome Prediction from Mixed Data (20 Patients) -- Two Stage Least Squares for Linear Models with Problematic Predictors (35 Patients) -- Autoregressive Models for Longitudinal Data (120 Monthly Population Records) -- Variance Components for Assessing the Magnitude of Random Effects (40 Patients) -- Ordinal Scaling for Clinical Scores with Inconsistent Intervals (900 Patients) -- Loglinear Models for Assessing Incident Rates with Varying Incident Risks (12 Populations) -- Loglinear Models for Outcome Categories (445 Patients) -- More on Polytomous Outcome Regressions (450 Patients) -- Heterogeneity in Clinical Research: Mechanisms Responsible (20 Studies) -- Performance Evaluation of Novel Diagnostic Tests (650 and 588 Patients) -- Quantile - Quantile Plots, a Good Start for Looking at Your Medical Data (50 Cholesterol Measurements and 52 Patients) -- Rate Analysis of Medical Data Better than Risk Analysis (52 Patients) -- Trend Tests Will Be Statistically Significant if Traditional Tests Are not (30 and 106 Patients) -- Doubly Multivariate Analysis of Variance for Multiple Observations from Multiple Outcome Variables (16 Patients) -- Probit Models for Estimating Effective Pharmacological Treatment Dosages (14 Tests) -- Interval Censored Data Analysis for Assessing Mean Time to Cancer Relapse (51 Patients) -- Structural Equation Modeling with SPSS Analysis of Moment Structures (Amos) for Cause Effect Relationships I (35 Patients) -- Structural Equation Modeling with SPSS Analysis of Moment Structures (Amos) for Cause Effect Relationships II (35 Patients) -- Firth's Bias-adjusted Estimates for Biased Logistic Data Models (23 Challenger launchings) -- Omics Research (125 Patients, 24 Predictor Variables) -- Sparse Canonical Correlation Analysis (12209 Genes in 45 Glioblastoma Carriers) -- Eigenvalues, Eigenvectors and Eigenfunctions (45 and 250 Patients) -- Section III Rules Models -- Neural Networks for Assessing Relationships that are Typically Nonlinear (90 Patients) -- Complex Samples Methodologies for Unbiased Sampling (9,678 Persons) -- Correspondence Analysis for Identifying the Best of Multiple Treatments in Multiple Groups (217 Patients) -- Decision Trees for Decision Analysis (1004 and 953 Patients) -- Multidimensional Scaling for Visualizing Experienced Drug Efficacies (14 Pain-killers and 42 Patients) -- Stochastic Processes for Long Term Predictions from Short Term Observations -- Optimal Binning for Finding High Risk Cut-offs (1445 Families) -- Conjoint Analysis for Determining the Most Appreciated Properties of Medicines to Be Developed (15 Physicians) -- Item Response Modeling for Analyzing Quality of Life with Better Precision (1000 Patients) -- Survival Studies with Varying Risks of Dying (50 and 60 Patients) -- Fuzzy Logic for Improved Precision of Pharmacological Data Analysis (9 Induction Dosages) -- Automatic Data Mining for the Best Treatment of a Disease (90 Patients) -- Pareto Charts for Identifying the Main Factors of Multifactorial Outcomes (2000 Admissions to Hospital) -- Radial Basis Neural Networks for Multidimensional Gaussian Data (90 persons) -- Automatic Modeling for Drug Efficacy Prediction (250 Patients) -- Automatic Modeling for Clinical Event Prediction (200 Patients) -- Automatic Newton Modeling in Clinical Pharmacology (15 Alfentanil dosages, 15 Quinidine time-concentration relationships) -- Spectral Plots for High Sensitivity Assessment of Periodicity (6 Years’ Monthly C Reactive Protein Levels) -- Runs Test for Identifying Best Analysis Models (21 Estimates of Quantity and Quality of Patient Care) -- Evolutionary Operations for Health Process Improvement (8 Operation Room Settings) -- Bayesian Networks for Cause Effect Modeling (600 Patients) -- Support Vector Machines for Imperfect Nonlinear Data (200 Patients) -- Multiple Response Sets for Visualizing Clinical Data Trends (811 Patient Visits) -- Protein and DNA Sequence Mining -- Iteration Methods for Crossvalidation (150 Patients) -- Testing Parallel-groups with Different Sample Sizes and Variances (5 Parallel-group Studies) -- Association Rules between Exposure and Outcome (50 and 60 Patients) -- Confidence Intervals for Proportions and Differences in Proportions (100 and 75 Patients) -- Ratio Statistics for Efficacy Analysis of New Drugs 50 Patients) -- Fifth Order Polynomes of Circadian Rhythms (1 Patient) -- Gamma Distribution for Estimating the Predictors of Medical Outcomes (110 Patients) -- Index.
    Abstract: Adequate health and health care is no longer possible without proper data supervision from modern machine learning methodologies like cluster models, neural networks, and other data mining methodologies. The current book is the first publication of a complete overview of machine learning methodologies for the medical and health sector, and it was written as a training companion, and as a must-read, not only for physicians and students, but also for any one involved in the process and progress of health and health care. In this second edition the authors have removed the textual errors from the first edition. Also, the improved tables from the first edition, have been replaced with the original tables from the software programs as applied. This is, because, unlike the former, the latter were without error, and readers were better familiar with them. The main purpose of the first edition was, to provide stepwise analyses of the novel methods from data examples, but background information and clinical relevance information may have been somewhat lacking. Therefore, each chapter now contains a section entitled "Background Information". Machine learning may be more informative, and may provide better sensitivity of testing than traditional analytic methods may do. In the second edition a place has been given for the use of machine learning not only to the analysis of observational clinical data, but also to that of controlled clinical trials. Unlike the first edition, the second edition has drawings in full color providing a helpful extra dimension to the data analysis. Several machine learning methodologies not yet covered in the first edition, but increasingly important today, have been included in this updated edition, for example, negative binomial and Poisson regressions, sparse canonical analysis, Firth's bias adjusted logistic analysis, omics research, eigenvalues and eigenvectors. .
    Type of Medium: Online Resource
    Pages: XXX, 667 p. 548 illus., 131 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030339708
    DDC: 610.72
    Language: English
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  • 47
    Keywords: Medical microbiology. ; Parasitology. ; Microbiology. ; Medicine Research. ; Biology Research. ; Medical Microbiology. ; Parasitology. ; Microbiology. ; Biomedical Research.
    Description / Table of Contents: Eukaryome: Emerging field with profound translational potential -- Resolving amoebozoan encystation from Dictyostelium evo-devo and amoebozoan comparative genomics -- Integrative omics analysis of the effect of bacteria on the resistance of Entamoeba histolytica to oxidative stress -- Histomonas meleagridis molecular traits –from past to future -- Exploring the biology and evolution of Blastocystis and its role in the microbiome -- Advances in the study of Blastocystis spp. in Mexico: prevalence, genetic diversity, clinical association and their possible role in the human intestine -- Cryptosporidium infection in Bangladesh children -- The current molecular epidemiological scenario of Cryptosporidium, Giardia and Blastocystis in Spain. Implication for public health -- The protozoome of the periodontal sulcus: from health to disease -- Tritrichomonas spp. and Their Impact on Gut Immune Homeostasis -- Contribution of host immunity to the development of Entamoeba histolytica-induced liver abscess -- Oxidative Stress And Heat Stress In Experimental Amoebic Liver Abscess -- Role of Extracellular Traps promoted by intestinal parasites. Relationship with virulence -- Parasite secretory molecules in host-parasite interaction -- The Role of Host PKCα during Intracellular Cryptosporidium Infection -- Immune response triggered by Entamoeba histolytica in a 3D-intestinal model -- Receptors for phagocytosis and trogocytosis in Entamoeba histolytica -- PtdIns(3,4,5)P3 binding protein screening reveals unique molecules involved in endocytic processes -- Molecular insights into E. histolytica mediated host tissue invasion -- Vesicular trafficking in Entamoeba histolytica is essential for its virulence -- MOLECULAR CHARACTERIZATION OF Entamoeba histolytica tRNA GENES -- Gene silencing and overexpression to study pathogenicity factors of Entamoeba histolytica -- Polyadenylation machineries in intestinal parasites: latest advances in the protozoan parasite Entamoeba histolytica -- Probiotics as anti-Giardia defenders: Overview on putative control mechanisms -- A protocol to quantify cellular morphodynamics: from cell labelling to automatic image analysis.-.
    Abstract: The intestine is home to diverse bacterial communities forming the microbiome that influences host nutrition, immune functions and health. DNA-based methods have been instrumental to gain insight into the microbial eukaryotic diversity of the human gut. For instance, the microbiome share the intestinal ecosystem with a population of uni- and multi-cellular eukaryotic organisms. These eukaryotic organisms are very common and often very abundant in individuals with intestinal healthy conditions as well as those with intestinal diseases. The impact of the relationship between bacterial and eukaryotic organisms within the intestinal ecosystem on homeostasis and intestinal diseases is limited and can be considered an important emerging field of research. In addition, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called “intestinal eukaryome”, that include fungi, protists and helminths. All these organisms and their interplay with bacteria and the human immune system are a challenge to assess the impact (present and future) of intestinal infectious diseases on public health. This book presents an overview of the science presented and discussed in the First Eukaryome Congress, held from October 16th to 18th, 2019 at Pasteur Institute in Paris, France. This contributed volume is of special interest for PhD students, postdoctoral fellows, researchers and clinicians interested in the effect of the eukaryotic microbiome on human health.
    Type of Medium: Online Resource
    Pages: XVII, 367 p. 60 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030448264
    DDC: 616.9041
    Language: English
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  • 48
    Keywords: Biotechnology. ; Regenerative medicine. ; Pharmaceutical chemistry. ; Neurosciences. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Pharmaceutics. ; Neuroscience. ; Chemical Bioengineering.
    Description / Table of Contents: Part I. Novel Bioinspired Biomaterials for Regenerative Medicine -- Chapter 1. Natural Sources and Applications of Demineralized Bone Matrix in the Field of Bone and Cartilage Tissue Engineering -- Chapter 2. Application of Gellan Gum-based Scaffold for Regenerative Medicine -- Chapter 3. Natural Fibrous Protein for Advanced Tissue Engineering Applications: Focusing on Silk Fibroin and Keratin -- Part II. Bioinspired 3D Bioprinting Hydrogel for Regenerative Medicine -- Chapter 4. Silk Fibroin Bioinks for Digital Light Processing (DLP) 3D Bioprinting -- Chapter 5. 3D-Bioprinting of Tissue Models with Customized Bioinks -- Chapter 6. Visible Light-curable Hydrogel Systems for Tissue Engineering and Drug Delivery -- Part III. Regulation of Stem Cell Fate by Bioinspired Biomaterials -- Chapter 7. Scaffolds for Cartilage Regeneration: To Use or Not to Use -- Chapter 8. Bio-application of Inorganic Nanomaterials in Tissue Engineering -- Chapter 9. Directional Cell Migration Guide for Improved Tissue Regeneration -- Part IV. Cutting-Edge Enabling Technology for Regenerative Medicine -- Chapter 10. Extracellular Vesicles: The Next Frontier in Regenerative Medicine and Drug Delivery -- Chapter 11. Application of Tissue Engineering and Regenerative Medicine in Maternal-fetal Medicine -- Chapter 12. Fundamentals and Current Strategies for Peripheral Nerve Repair and Regeneration -- Chapter 13. Protein-based Drug Delivery in Brain Tumor Therapy -- Chapter 14. Human Hair: Scaffold Materials for Regenerative Medicine.
    Abstract: This book is the first of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. Topics addressed in this volume, which is devoted to bioinspired biomaterials, range from novel biomaterials for regenerative medicine through to emerging enabling technologies with applications in, for example, drug delivery, maternal–fetal medicine, peripheral nerve repair and regeneration, and brain tumor therapy. New bioinspired hydrogels receive detailed attention in the book, and a further focus is the use of bioinspired biomaterials in the regulation of stem cell fate. Here the coverage includes the role of scaffolds in cartilage regeneration, the bioapplication of inorganic nanomaterials in tissue engineering, and guidance of cell migration to improve tissue regeneration. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials. .
    Type of Medium: Online Resource
    Pages: X, 229 p. 45 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811532580
    Series Statement: Advances in Experimental Medicine and Biology, 1249
    DDC: 660.6
    Language: English
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  • 49
    Keywords: Biotechnology. ; Regenerative medicine. ; Pharmaceutical chemistry. ; Neurosciences. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Pharmaceutics. ; Neuroscience. ; Chemical Bioengineering.
    Description / Table of Contents: Part I. Novel Biomimicked Biomaterials for Regenerative Medicine -- Chapter 1. Bone Regeneration using Duck’s Feet Derived Collagen Scaffold as an Alternative Collagen Source -- Chapter 2. Decellularized Extracellular Matrices for Tissue Engineering and Regeneration -- Part II. Novel Biomimicked Hydrogel for Regenerative Medicine -- Chapter 3. Injectable in situ-forming Hydrogels for Protein and Peptide Delivery -- Chapter 4. Alginate Hydrogels as 3D Cell Encapsulation Matrices for Tissue Engineering and Regenerative Medicine -- Chapter 5. Design of Advanced Polymeric Hydrogels for Tissue Regenerative Medicine: Oxygen-controllable Hydrogel Materials -- Chapter 6. Enhancing Osteochondral Tissue Regeneration of Gellan Gum by Incorporating Gallus Gallus var Domesticus Derived Demineralized Bone Particle -- Part III. Control of Stem Cell Fate by Biomaterials for Regenerative Medicine -- Chapter 7. The Development of Extracellular Vesicles-Integrated Biomaterials for Bone Regeneration -- Chapter 8. In vivo Evaluation of the Biocompatibility of Biomaterial Device -- Chapter 9. Cell Response to Materials for Biomedical Engineering -- Chapter 10. Regulation of Stem Cell Functions by Micro-patterned Structures -- Part IV. Nano-Intelligent Biocomposites for Regenerative Medicine -- Chapter 11. Natural Polyphenols as Modulators of the Fibrillization of Islet Amyloid Polypeptide -- Chapter 12.Recent Advances of Biphasic Calcium Phosphate Bioceramics for Bone Tissue Regeneration -- Chapter 13. Surface-modifying Polymers for Blood-Contacting Polymeric Biomaterials.
    Abstract: This book is the second of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. In this volume, which is devoted to biomimetic biomaterials, the opening section discusses bone regeneration by means of duck’s feet-derived collagen scaffold and the use of decellularized extracellular matrices. The role of various novel biomimetic hydrogels in regenerative medicine is then considered in detail. The third section focuses on the control of stem cell fate by biomimetic biomaterials, covering exosome-integrated biomaterials for bone regeneration, cellular responses to materials for biomedical engineering, and the regulation of stem cell functions by micropatterned structures. Finally, the use of nano-intelligent biocomposites in regenerative medicine is addressed, with discussion of, for example, recent advances in biphasic calcium phosphate bioceramics and blood-contacting polymeric biomaterials. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.
    Type of Medium: Online Resource
    Pages: X, 198 p. 60 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811532627
    Series Statement: Advances in Experimental Medicine and Biology, 1250
    DDC: 660.6
    Language: English
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  • 50
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Immunology. ; Medical microbiology. ; Molecular genetics. ; Stem cells. ; Cell death. ; Cancer Biology. ; Immunology. ; Medical Microbiology. ; Molecular Genetics. ; Stem Cell Biology. ; Cell Death.
    Description / Table of Contents: Chapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy – An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.
    Abstract: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
    Type of Medium: Online Resource
    Pages: VII, 280 p. 38 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811569302
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Cytology. ; Nanoscience. ; Biotechnology. ; Cell Biology. ; Nanophysics.
    Description / Table of Contents: Chapter 1: Introduction: Fluorescent materials for cell imaging -- Chapter 2: Semiconductor quantum dots for cell imaging -- Chapter 3: Carbon nanodots for cell imaging -- Chapter 4: Silicon nanoparticles for cell imaging -- Chapter 5: Fluorescent metal nanoclusters for bioimaging -- Chapter 6: Lanthanide-based upconversion nanoparticles for bioimaging applications -- Chapter 7: Conjugated polymers and polymer dots for cell imaging -- Chapter 8: Aggregation-induced emission (AIE) probes for cell imaging -- Chapter 9: Luminescent coordination compounds for cell imaging.
    Abstract: This book focuses on the latest fluorescent materials for cell imaging. Cell imaging is a widely used basic technique that helps scientists gain a better understanding of biological functions through studies of cellular structure and dynamics. In the past decades, the development of a variety of new fluorescent materials has significantly extended the applications of cellular imaging techniques. This book presents recently developed fluorescent materials, including semiconductor quantum dots, carbon dots, silicon nanoparticles, metal nanoclusters, upconversion nanoparticles, conjugated polymers/polymer dots, aggregation-induced emission (AIE) probes, and coordination compounds, used for various cellular imaging purposes. It will appeal to cell biologists and other researchers in academia, industry and clinical settings who are interested in the technical development and advanced applications of fluorescence imaging in cells, tissues and organisms to explore the mechanisms of biological functions and diseases.
    Type of Medium: Online Resource
    Pages: V, 247 p. 140 illus., 128 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811550621
    DDC: 660.6
    Language: English
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  • 52
    Keywords: Fungi. ; Mycology. ; Microbiology. ; Plant biotechnology. ; Renewable energy sources. ; Biology Technique. ; Plant diseases. ; Fungi. ; Plant Biotechnology. ; Microbiology. ; Renewable Energy. ; Biological Techniques. ; Plant Pathology.
    Description / Table of Contents: Preface -- Biofuels: challenges and the promises of fungi in biofuel production -- Plant pathogenic fungi for bioethanol production: mechanisms of actions -- Plant pathogenic fungi for biodiesel production -- Plant pathogenic fungi for VOCs production -- Plant probiotic fungi as a new source for Bioethanol Production -- Endophytic fungi for biofuel production -- Brown and white rot fungi for biofuel production -- Gut fungi for biofuel production -- Consolidated bioprocessing: highly efficient fungi for biofuel production -- Process design in fungal-based biofuel production systems -- Life cycle assessment (LCA) of fungal-based biofuel production systems -- Thermodynamics aspects of fungal-based biofuel production systems -- Modeling and optimization to enhance fungal-based biofuel production -- Index.
    Abstract: Due to the huge quantity and diverse nature of their metabolic pathways, fungi have great potential to be used for the production of different biofuels such as bioethanol, biobutanol, and biodiesel. This book presents recent advances, as well as challenges and promises, of fungal applications in biofuel production, subsequently discussing plant pathogenic fungi for bioethanol and biodiesel production, including their mechanisms of action. Additionally, this book reviews biofuel production using plant endophytic fungi, wood-rotting fungi, fungal biocontrol agents, and gut fungi, and it investigates highly efficient fungi for biofuel production and process design in fungal-based biofuel production systems. Finally, life cycle assessment of fungal-based biofuel production systems are discussed in this volume.
    Type of Medium: Online Resource
    Pages: XI, 233 p. 35 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030444884
    Series Statement: Fungal Biology,
    DDC: 579.5
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Life sciences. ; Ecology . ; Environment. ; Agriculture. ; Pharmacology. ; Life Sciences. ; Ecology. ; Environmental Sciences. ; Agriculture. ; Pharmacology.
    Description / Table of Contents: 1. What is the problem? Pesticides in our everyday life -- 2. Pesticide impacts on the environment, and humans -- 3. Where are the solutions to the pesticide problem?
    Abstract: This book is a sound science report about the consequences of pesticides to nature, health and environment. The book shares essential insights into the use of pesticides in agriculture, discusses the politics, rhetoric and profits involved, addresses the potential health and ecological risks of pesticides in our daily lives, and debates possible solutions. Is agriculture without pesticides possible at all? Moreover, the author gives insight into his scientific work, the set-up of the experiments, and also writes about his very own experiences with the media and press after publication of his studies. For many years, Johann G. Zaller, an ecologist at the University of Natural Resources and Life Sciences in Vienna, and his team, have been researching applied chemicals and their effects on the environment. Their findings, together with relevant literature and media reports, are presented in this book, which offers a unique resource for anyone who wants to know the nature and background of pesticides and how we come into contact with them in our daily lives. Ever ate an apple? Read this book!
    Type of Medium: Online Resource
    Pages: XV, 305 p. 9 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030505301
    DDC: 570
    Language: English
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  • 54
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Pharmacy. ; Medical sciences. ; Drug development. ; Pharmacology. ; Pharmacy. ; Preclinical Research.
    Description / Table of Contents: Chapter 1. Introduction to mammalian circadian clock system -- Chapter 2. Introduction to pharmacokinetics -- Chapter 3. Circadian clock and metabolic diseases -- Chapter 4. Circadian clock and CYP metabolism -- Chapter 5. Circadian clock and non-CYP phase I metabolism -- Chapter 6. Circadian clock and phase II metabolism -- Chapter 7. Circadian clock and uptake transporters -- Chapter 8. Circadian clock and efflux transporters -- Chapter 9. Role of pharmacokinetics in chronotherapeutics -- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.
    Abstract: This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.
    Type of Medium: Online Resource
    Pages: VII, 253 p. 59 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811588075
    DDC: 615
    Language: English
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  • 55
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Computational intelligence. ; Bioinformatics. ; Biotechnology. ; Computational Intelligence. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Feature engineering and computational intelligence in ECG monitoring – an introduction -- Chapter 2. Representative Databases for Feature Engineering and Computational Intelligence in ECG Processing -- Chapter 3. An Overview of signal quality indices on dynamic ECG signal quality assessment -- Chapter 4. Signal quality features in dynamic ECGs -- Chapter 5. Motion Artifact Suppression Method in Wearable ECG -- Chapter 6. Data Augmentation for Deep Learning based ECG analysis -- Chapter 7. Study on Automatic Classification of Arrhythmias -- Chapter 8. ECG Interpretation with deep learning -- Chapter 9. Visualizing ECG contribution into Convolutional Neural Network classification -- Chapter 10. Atrial fibrillation detection in dynamic signals -- Chapter 11. Applications of Heart rate variability in Sleep Apnea -- Chapter 12. False Alarm Rejection for ICU ECG Monitoring -- Chapter 13. Respiratory Signal Extraction from ECG Signal -- Chapter 14. Noninvasive Recording of Cardiac Autonomic Nervous Activity--What’s behind ECG? -- Chapter 15. A questionnaire study on artificial intelligence and its effects on individual health and wearable device.
    Abstract: This book discusses feature engineering and computational intelligence solutions for ECG monitoring, with a particular focus on how these methods can be efficiently used to address the emerging challenges of dynamic, continuous & long-term individual ECG monitoring and real-time feedback. By doing so, it provides a “snapshot” of the current research at the interface between physiological signal analysis and machine learning. It also helps clarify a number of dilemmas and encourages further investigations in this field, to explore rational applications of feature engineering and computational intelligence in ECG monitoring. The book is intended for researchers and graduate students in the field of biomedical engineering, ECG signal processing, and intelligent healthcare.
    Type of Medium: Online Resource
    Pages: X, 268 p. 101 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811538247
    DDC: 660.6
    Language: English
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  • 56
    Keywords: Microbiology. ; Industrial microbiology. ; Medical microbiology. ; Biotechnology. ; Microbiology. ; Industrial Microbiology. ; Medical Microbiology. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Microbial ecosystem and anthropogenic impacts -- Part 1. Microbes in Agriculture -- Chapter 2. Recent advances in Plant-microbe interaction -- Chapter 3. Microbes in crop production: Formulation and Application -- Chapter 4. Microorganisms improving food quality and safety -- Chapter 5. Microbes in Soil and their Metagenomics -- Part 2. Microbes in Nanotechnology -- Chapter 6. Microbial cell factories in nanotechnology -- Chapter 7. Nanotechnology and food microbiology -- Part 3. Microbes in Genetic Engineering -- Chapter 8. Bioengineered microbes in disease therapy -- Chapter 9. Benefits and biohazards of microbial recombinants -- Part 4. Microbial Enzymes & Applications -- Chapter 10. Extremophile Microorganisms and Their Industrial Applications -- Chapter 11. Innovative techniques for improving microbial enzyme production -- Chapter 12. Microbial enzymes from in vitro to market -- Part 5. Microbes in Bioremediation -- Chapter 13. Microbial clean up strategy for polluted water -- Chapter 14. Microbial clean up strategy for eating garbage -- Part 6. Microbes in Industries -- Chapter 15. Microbes in Food and beverage industry -- Chapter 16. Microbes in pharmaceutical industry -- Chapter 17. Industrial Potential of Microbial Enzymes -- Part 7. Microbes in Medicine -- Chapter 18. Living medicines for health and disease management -- Chapter 19. Fighting microbes with microbes -- Chapter 20. Impact of Human Microbiome on health -- Part 8. Microbes in Forensic Science -- Chapter 21. An Introduction to Microbial forensics -- Chapter 22. Microbial Forensics: A new boon to Legal Justice -- Part 9. Microbes in Space -- Chapter 23. Microbes supporting life off-planet. .
    Abstract: This book focuses on the application of microbes in all fields of biology. There is an urgent need to understand and explore new microbes, their biological activities, genetic makeup and further opportunities for utilizing them. The book is divided into sections, highlighting the application of microbes in agriculture, nanotechnology, genetic engineering, bioremediation, industry, medicine and forensic sciences, and describing potential future advances in these fields. It also explores the potential role of microbes in space and how they might support life on a different planet. .
    Type of Medium: Online Resource
    Pages: XV, 415 p. 16 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811540998
    DDC: 579
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Cytology. ; Bioinformatics. ; Biology Technique. ; Biotechnology. ; Cell Biology. ; Computational and Systems Biology. ; Biological Techniques.
    Description / Table of Contents: Workflows and Components of Bioimage Analysis -- Measurements of Intensity Dynamics at the Periphery of the Nucleus -- 3D Quantitative Colocalisation Analysis -- The NEMO Dots Assembly: Single-Particle Tracking and Analysis -- Introduction to MATLAB: Image Analysis & Brownian Motion -- Resolving the process of Clathrin Mediated Endocytosis Using Correlative Light & Electron Microscopy (CLEM).
    Abstract: This Open Access textbook provides students and researchers in the life sciences with essential practical information on how to quantitatively analyze data images. It refrains from focusing on theory, and instead uses practical examples and step-by step protocols to familiarize readers with the most commonly used image processing and analysis platforms such as ImageJ, MatLab and Python. Besides gaining knowhow on algorithm usage, readers will learn how to create an analysis pipeline by scripting language; these skills are important in order to document reproducible image analysis workflows. The textbook is chiefly intended for advanced undergraduates in the life sciences and biomedicine without a theoretical background in data analysis, as well as for postdocs, staff scientists and faculty members who need to perform regular quantitative analyses of microscopy images.
    Type of Medium: Online Resource
    Pages: X, 170 p. 69 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030223861
    Series Statement: Learning Materials in Biosciences,
    DDC: 660.6
    Language: English
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  • 58
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Psychobiology. ; Human behavior. ; Physical anthropology. ; Cognitive psychology. ; Animal welfare Moral and ethical aspects. ; Animal migration. ; Animal culture. ; Behavioral Neuroscience. ; Physical-Biological Anthropology. ; Cognitive Psychology. ; Animal Ethics. ; Animal Migration. ; Animal Science.
    Description / Table of Contents: Part I: Introduction -- Chapter 1: Recent developments in primatology and their relevance to the study of Tibetan macaques -- Part II: Social Behavior and Dynamics in Tibetan Macaques -- Chapter 2: Social and Life History Strategies of Tibetan Macaques at Mt. Huangshan -- Chapter 3: Size Matters in Primate Societies: How Social Mobility Relates to Social Stability in Tibetan and Japanese Macaques -- Chapter 4: Behavioral exchange and interchange as strategies to facilitate social relationships in Tibetan macaques -- Chapter 5: Social relationships impact collective decision-making in Tibetan macaques -- Chapter 6: Considering Social Play in Primates: A Case Study in Juvenile Tibetan Macaques (Macacathibetana) -- Chapter 7: The Vocal Repertoire of Tibetan Macaques (Macacathibetana) and Congeneric Comparisons -- Chapter 8: Tibetan Macaque Social Style: Co-variant and Quasi-independent Evolution -- Part III: Evolution of Rituals: Insights from Bridging Behavior -- Chapter 9: Preliminary observations of female-female bridging behavior in Tibetan macaques (Macacathibetana) at Mt. Huangshan, China -- Chapter 10: Bridging Behavior and Male-Infant Interactions in Macacathibetana and M. assamensis: Insight into the Evolution of Social Behavior in the sinica Species-group of Macaques -- Part IV: Livingwith Microbes, Parasites, and Diseases -- Chapter 11: The gut microbiome of Tibetan macaques: composition, influencing factors and function in feeding ecology -- Chapter 12: Medicinal Properties in the Diet of Tibetan Macaques at Mt. Huangshan - A Case for Self-medication -- Chapter 13: Primate infectious disease ecology: Insights and future directions at the human-macaque interface -- Part V: Emerging Technologies in Primatology -- Chapter 14: High field MRI technology for behavioral and cognitive studies in macaques in vivo.
    Abstract: This open access book summarizes the multi-disciplinary results of one of China’s main primatological research projects on the endemic Tibetan macaque (Macaca thibetana), which had continued for over 30 years, but which had never been reported on systematically. Dedicated to this exceptional Old World monkey, this book makes the work of Chinese primatologists on the social behavior, cooperation, culture, cognition, group dynamics, and emerging technologies in primate research accessible to the international scientific community. One of the most impressive Asian monkeys, and the largest member of its genus, the Tibetan macaque deserves to be better known. This volume goes a long way towards bringing this species into the spotlight with many excellent behavioral analyses from the field.- Frans de Waal, Professor of Psychology, Emory University, USA. Macaques matter. To understand primate patterns and trends, and to gain important insight into humanity, we need to augment and expand our engagement with the most successful and widespread primate genus aside from Homo. This volume focuses on the Tibetan macaque, a fascinating species with much to tell us about social behavior, physiology, complexity and the macaque knack for interfacing with humans. This book is doubly important for primatology in that beyond containing core information on this macaque species, it also reflects an effective integrated collaboration between Chinese scholars and a range of international colleagues—exactly the type of collaborative engagement primatology needs. This volume is a critical contribution to a global primatology. - Agustín Fuentes, Professor of Anthropology, University of Notre Dame, USA. I have many fond memories of my association with Mt. Huangshan research beginning in 1983, when together with Professor Qishan Wang we established this site. It is such a beautiful place and I miss it. It is gratifying to see how far research has progressed since we began work there, becoming more internationalized and very much a collaborative endeavor under the long-term direction of Professor Jin-Hua Li and colleagues. This book highlights the increased interest in this species, representing a variety of disciplines ranging from macro aspects of behavior, cognition and sociality, to micro aspects of microbes, parasites and disease, authored by a group of renowned Chinese and international primatologists. I applaud their efforts and expect more interesting work to come from this site in the years ahead.- Kazuo Wada, Professor Emeritus, Kyoto University, Japan.
    Type of Medium: Online Resource
    Pages: XVI, 302 p. 93 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030279202
    Series Statement: Fascinating Life Sciences,
    DDC: 612.8
    Language: English
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  • 59
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Veterinary microbiology. ; Food science. ; Agriculture Economic aspects. ; Plant Science. ; Veterinary Microbiology. ; Food Science. ; Agricultural Economics.
    Description / Table of Contents: Chapter 1. Introduction -- Part I. The role of natural products and remedies in treating animal diseases -- Chapter 2. The pharmacological and nutritional significance of plant natural products: An alternative for animal health -- Chapter 3. Alternative antimicrobials - medicinal plants and their influences on animal infectious diseases -- Chapter 4. Herbs used for horses in British Columbia and Trinidad and Tobago -- Chapter 5. Plants for controlling parasites in goats -- Chapter 6. Ethnoveterinary practices for control of ticks in Africa -- Part II. Sociological aspects and considerations relating to documentation of ethnoceterinary medicine -- Chapter 7. Gender aspects and multiple contexts in ethnoveterinary practice and science -- Chapter 8. Towards a better understanding of African ethnoveterinary medicine and husbandry -- Part III. Ethnoveterinary medicine around the world -- Chapter 9. Ethnoveterinary medicine and medicinal plants used in the treatment of livestock diseases in Cameroon -- Chapter 10. Ethnoveterinary medicinal plants used in South Africa -- Chapter 11. Ethnoveterinary plants and practices for the control of ticks and tick-borne diseases in South Africa -- Chapter 12. Ethnoveterinary medicine: a Zimbabwean perspective -- Chapter 13. Ethnoveterinary medicine in the Maghreb -- Chapter 14. Natural remedies for animal health in Latin America -- Chapter 15. Local practice of cattle farming and ethnoveterinary medicine in Estonia: case study of Saaremaa and Muhumaa -- Chapter 16. Belarusian ethnoveterinary medicine: ritual practices and traditional remedies -- Chapter 17. The use of medicinal plants for animal health in the Spanish inventory of traditional knowledge -- Index.
    Abstract: The importance of a complementary approach to animal health is highlighted in this book, with core themes encompassing reviews of traditional veterinary medicine for common diseases afflicting livestock, as well as local practices in different areas of the world. The book includes chapters on ethnoveterinary medicine used to prevent and treat ticks and tick-borne diseases, infectious diseases and parasites. Ethnoveterinary practices in parts of the world which have not been comprehensively reviewed before are highlighted, including Estonia, Belarus and the Maghreb - the north-western tip of Africa. A fascinating account of African ethnoveterinary medicine and traditional husbandry practices is provided by a veteran in the field with a wealth of practical experience in the area. Neglected areas of research involve the relationship of ethnoveterinary medicine with environmental, ethical, cultural and gender aspects, and leading experts explore these issues. The book is intended to provide an informative compilation of current research and future prospects in ethnoveterinary medicine, which hopes to inform and encourage investigations in new directions. Sustainable development requires a concerted effort to combine indigenous knowledge systems with scientific research to improve animal health. This is the case not only in rural areas where access to orthodox veterinary health care may be limited, but also against the backdrop of antibiotic resistance and increased demand for alternative and complementary therapies to enhance the health of both production and companion animals. Students, academics and veterinary professionals will find this book a useful addition to knowledge on present and future aspects of ethnoveterinary research.
    Type of Medium: Online Resource
    Pages: XIII, 435 p. 48 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030322700
    DDC: 580
    Language: English
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  • 60
    Keywords: Landscape ecology. ; Soil science. ; Biotic communities. ; Human geography. ; Agriculture. ; Landscape Ecology. ; Soil Science. ; Ecosystems. ; Human Geography. ; Agriculture.
    Description / Table of Contents: Modelling and simulation of agricultural landscapes -- Challenges and perspectives for integrated landscape modelling to support sustainable land use management in agrolandscapes -- Application of ecosystem modelling methodology on rural areas of Crimea - Systematic approach -- Integral assessment of condition and sustainability of socio-ecological-economic systems -- The use of observation methods and model approaches for estimating regional crop evapotranspiration and yield in agro-landscapes -- Development of landscape-adaptive land use of the Upper Volga region based on geostatistical methods -- Modelling of the suitability of lands to the agrarian use and their resistance to negative processes -- A GIS-based model for the enhancement of rural landscapes: the case-study of Valdera - Tuscany (Italy) -- Models for describing landscape hydrochemical discharge in mountain countries -- Agent-based modelling of a simple synthetic rangeland ecosystem -- The use of multitemporal spectral information to improve the classification of agricultural crops in landscapes -- Global evaluation of the status and sustainability of terrestrial landscapes and water bodies -- Spatial Estimation of Estonian Forest Landscapes’ Soil Cover Humus Status: Methods, Model samples and Assessments -- Dynamics of soil organic matter in agricultural landscapes -- Model based assessment of nutrient load into water bodies from different landscape types -- Model-based estimation of irrigation water demand for different agricultural crops under climate change, presented for the Federal State of Brandenburg, Germany -- Forecasting scanning branches of the hysteresis soil water-retention capacity for calculation of precise irrigation rates in agrolandscapes using a mathematical model -- Estimation of Leaf Area Index (LAI) of Russian Forests Using a Mechanical Model and Forest Inventory Data -- Assessment approach of the spatial wheat cultivation risk for the main cereal cropping regions of Russia -- Model based forecasting winter wheat yields using landscape and climate data -- Actual and model-based assessment of Castor fiber populations for different reserves in the European part of Russia and their impact on ecosystems -- Modelling biodiversity and ecosystem services trade-offs in agricultural landscapes to support planning and policy-making -- Simulating the Effects of Agrochemicals and Other Risk-Bearing Management Measures on the Terrestrial Agrobiodiversity: the RISKMIN Approach -- LandCaRe-DSS – An interactive model-based decision support system for assessing the impacts of climate change on agriculture and agricultural landscapes -- A spatial analysis framework to assess responses of agricultural landscapes to climates and soils at regional scale -- Integrated modelling approach for land-use changes on different scales -- Assessment of soybeans crop management strategies using crop growth models for Central Brazil -- Estimation of Agro-landscape Productivity in Regional Scale using Dynamic Crop Models in a GIS Environment -- Landscape phenology modelling and decision support in Serbia.
    Abstract: This book contributes to a deeper understanding of landscape and regional modelling in general, and its broad range of facets with respect to various landscape parameters. It presents model approaches for a number of ecological and socio-economic landscape indicators, and also describes spatial decision support systems (DSS), frameworks, and model-based tools, which are prerequisites for deriving sustainable decision and solution strategies for the protection of comprehensively functioning landscapes. While it mainly focuses on the latest research findings in regional modelling and DSS in Europe, it also highlights the work of scientists from Russia. The book is intended for landscape modellers, scientists from various fields of landscape research, university teaching staff, and experts in landscape planning and management, landscape conservation and landscape policy.
    Type of Medium: Online Resource
    Pages: XXIII, 593 p. 201 illus., 175 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030374211
    Series Statement: Innovations in Landscape Research,
    DDC: 577.5
    Language: English
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    Keywords: Freshwater ecology. ; Marine ecology. ; Animal culture. ; Biotic communities. ; Physical geography. ; Evolution (Biology). ; Freshwater and Marine Ecology. ; Animal Science. ; Ecosystems. ; Earth System Sciences. ; Evolutionary Theory.
    Description / Table of Contents: Introduction: the Habitat and the Ecosystem -- Shallow Hardbottom of East Florida and the Caribbean and the Regional Shelf Setting -- Macroalgae and Cyanobacteria -- Invertebrates -- Fish Assemblages -- Marine Turtles -- Functional Ecological Attributes of Shallow Hardbottom -- Mitigating Shallow Hardbottom Impacts -- Literature Cited -- Appendices.
    Abstract: Nearshore hardbottom reefs of Florida’s east coast are used by over 1100 species of fishes, invertebrates, algae, and sea turtles. These rocky reefs support reproduction, settlement, and habitat use, and are energy sources and sinks. They are also buried by beach renourishment projects in which artificial reefs are used for mitigation. This comprehensive book is for research scientists and agency personnel, yet accessible to interested laypersons including beachfront residents and water-users. An unprecedented collection of research information and often stunning color photographs are assembled including over 1250 technical citations and 127 figures. These shallow reefs are part of a mosaic of coastal shelf habitats including estuarine seagrasses and mangroves, and offshore coral reefs. These hardbottom habitats are federally designated as Essential Fish Habitats - Habitats of Particular Concern and are important feeding areas for federally-protected sea turtles. Organismal and assemblage responses to natural and man-made disturbances, including climate change, are examined in the context of new research and management opportunities for east Florida’s islands in the sand. .
    Type of Medium: Online Resource
    Pages: XVIII, 472 p. 135 illus., 125 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030403577
    DDC: 577.6
    Language: English
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  • 62
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biomedical engineering. ; Biotechnology. ; Lasers. ; Radiology. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Biotechnology. ; Laser. ; Radiology.
    Description / Table of Contents: Introduction: Enhancing Detection and Early Cancer Recognition with Multimodal Optical Imaging and Spectral Analysis -- Malignant tissue optics -- Optical clearing of biological tissues: prospects of application for multimodal cancer diagnostics -- Multiparametric analysis of tumor using microscopic fluorescence imaging -- NIRS for brain cancer detection -- Exhaled air analysis using wideband wave number tuning range infrared laser photoacoustic spectroscopy -- Multispectral and multimodal fiber sensing in oncology -- Diagnostics of pigmented skin tumors based on laser-induced autofluorescence and diffuse reflectance spectroscopy -- Raman-based molecular imaging and analytics, Surface-enhanced Raman spectroscopy for cancer diagnostics, Raman/CARS/TPEF/SHG multimodal imaging as a pathological screening tool -- In vivo Multimodal Optical Biopsy of Skin Cancer -- Raman hyperspectroscopy and advanced statistics for cancer differentiation -- Intraoperative brain cancer detection with Label-Free Multimodal Optical Spectroscopy -- 3D confocal Raman and two-photon microscopy imaging of the skin -- Multimodal Optical Imaging for Cancer Detection -- Multidimentional and Multilevel Imaging: towards 3D histopathology -- Multimodal OCT for malignancy imaging -- Multimodal texture analysis of OCT tumor images -- Hyperspectral imaging and cancer detection -- Multimodal Deep Imaging using SORS and OCT: for precise cancer boundary detection -- FLIM imaging combined with MRI -- Terahertz spectroscopy of human brain tumor.
    Abstract: This book provides an in-depth description and discussion of different multi-modal diagnostic techniques for cancer detection and treatment using exact optical methods, their comparison, and combination. Coverage includes detailed descriptions of modern state of design for novel methods of optical non-invasive cancer diagnostics; multi-modal methods for earlier cancer diagnostic enhancing the probability of effective cancer treatment; modern clinical trials with novel methods of clinical cancer diagnostics; medical and technical aspects of clinical cancer diagnostics, and long-term monitoring. Biomedical engineers, cancer researchers, and scientists will find the book to be an invaluable resource. Introduces optical imaging strategies; Focuses on multimodal optical diagnostics as a fundamental approach; Discusses novel methods of optical non-invasive cancer diagnostics.
    Type of Medium: Online Resource
    Pages: XX, 597 p. 193 illus., 153 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030445942
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Wiesbaden :Springer Fachmedien Wiesbaden :
    Keywords: Entrepreneurship. ; New business enterprises. ; Entrepreneurship.
    Description / Table of Contents: Introduction -- Literature Review -- Methodology -- Results -- Discussion -- Conclusions -- Theoretical and Practical Contributions -- Limitations and Future Research.
    Abstract: The number of women entrepreneurs is growing rapidly worldwide, however, women are still less likely than men to start a new business. Two factors influencing this are barriers and drivers, however, the understanding of how their interaction affects women’s entrepreneurial intention, specifically across different contexts, is lacking. This study focuses on entrepreneurial intention of women across four different European countries, by adopting both a national and supranational perspective. The analysis is based on the Global Entrepreneurship Monitor (GEM) Germany, Poland, Spain, and Sweden 2015 database. Overall the thesis contributes to the literature of entrepreneurship and context and also the understanding of factors influencing women entrepreneurship in Europe. Iulia Stroila completed her master´s thesis under the supervision of Prof. Dr. Thomas Baakenand Dr. Sue Rossano Rivero at the University of Applied Sciences Münster, Germany. She has started as a Research Associate at the Science-to-Business Marketing Research Centre in 2019 and is enrolled as PhD student at the University of Adelaide; a collaborative PhD program with Münster University of Applied Sciences. .
    Type of Medium: Online Resource
    Pages: XIII, 91 p. 3 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783658315146
    Series Statement: Forschungsreihe der FH Münster,
    DDC: 658.421
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Microbiology. ; Renewable energy sources. ; Environmental management. ; Microbiology. ; Renewable Energy. ; Environmental Management.
    Description / Table of Contents: 1. Introduction -- 2. Water hyacinth: An Environmental Concern or A sustainable lignocellulosic substrate -- 3. Lignocellulolytic Enzymology -- 4. Pretreatment strategies: Unlocking of lignocellulosic substrate -- 5. Biological pretreatment: Need of the Future -- 6. Strategies for Saccharification of Lignocellulosic substrate -- Bioethanol production from Water hyacinth.
    Abstract: This book discusses the production of bioethanol from water hyacinth, a potential source of lignocellulosic biomass. Biofuels, as an alternative to fossil fuels, not only ensure energy security but also mitigate air pollution and reduce greenhouse emissions. Biofuels can be produced from sugar- and starch-rich food crops (first-generation biofuel) or lignocellulosic biomass (second-generation biofuel). However, the overexploitation of conventional lignocellulosic sources such as agro-industrial residues, dedicated herbaceous, hardwoods and softwoods and forest residues may lead to problems in terms of land management and biodiversity conservation. Non-conventional sources include industrial cellulosic waste, municipal solid waste and weeds. Of these, weeds are an attractive lignocellulosic source due to their prevalence and easy availability. Eichhornia crassipes, commonly known as water hyacinth, is one of the world’s most invasive weeds due to its rapid proliferation rate, efficient survival strategies in extreme conditions, and it has a significant impact on the environment, ecological communities, human health and socioeconomic development. Strategies including physical removal, chemical methods and biological control agents have proven inefficient in completely eradicating Eichhornia crassipes. On the other hand, water hyacinth has a low lignin and high holocellulose content and is a rich source of lignocellulosic biomass, and has therefore been exploited as a raw material for the production of biofuel, biogas, animal and fish feed, compost and other valuable products. Further, being an aquatic plant, it does not compete with food crops for land resources. The bioethanol-generating capacity of water hyacinth is comparable to that of agricultural waste, making it a potential raw material for biofuel production.
    Type of Medium: Online Resource
    Pages: X, 106 p. 4 illus., 2 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030356323
    DDC: 579
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Medical microbiology. ; Dermatology. ; Orthopedic surgery. ; Pharmacology. ; Medical Microbiology. ; Dermatology. ; Surgical Orthopedics.
    Description / Table of Contents: Part 1-Nanotechnology in Skin Infections -- Atopic dermatitis and current trends in pharmacological treatment - a nanoparticulate approach -- Acne vulgaris - recent trends on pharmacological and nanotechnological approaches in therapeutics -- Nitric oxide nanoparticles on skin infections: Current State and Future Prospects -- Metal Nanoparticles Based Antibacterial Nanocomposites for Skin Infections -- Combination therapy using metal nanoparticles for skin infection -- Applications of nanometals in cutaneous infections -- Antifungal nanotherapy: a novel approach to combat superficial fungal infections -- Biocompatible polymers for skin Nanomedicines -- Part 2-Nanotechnology on Soft-Tissue Infections -- Nanotechnological approach to manage diabetic foot ulcer -- Metal nanoparticles in wound infections -- Advances in nanomedicine for burn wound infection treatment -- Applications of chitosan in formulation of novel antibacterial agents and wound dressings -- Polymeric nanocomposites for skin and soft tissues -- Nanoformulations of polyphenols for the treatment of soft tissues infections -- Cutting Edge Nanotechnologies for Targeting Liver Disorders -- NanoCurcumin compounds formulations: Perspectives in skin and soft tissues infections -- Nanobiotechnology strategies for the treatment tegumentary and visceral leishmaniases, and emergence resistance -- Part 3-Nanotechnology in Bone Infections -- Artificial Scaffolds for Bone Tissue Engineering -- The bone biology and the nanotechnology for bone infections and bone engineering -- Part 4-Nanotechnology and Toxicity -- Genotoxicity studies of Silver Nanoparticles in in vivo and in vitro models.
    Abstract: The main goal of the present book is to deal with the role of nanobiotechnology in skin, soft tissue and bone infections since it is difficult to treat the infections due to the development of resistance in them against existing antibiotics. The present interdisciplinary book is very useful for a diverse group of readers including nanotechnologists, medical microbiologists, dermatologists, osteologists, biotechnologists, bioengineers. Nanotechnology in Skin, Soft-Tissue, and Bone Infections is divided into four sections: Section I- includes role of nanotechnology in skin infections such as atopic dermatitis, and nanomaterials for combating infections caused by bacteria and fungi. Section II- incorporates how nanotechnology can be used for soft-tissue infections such as diabetic foot ulcer and other wound infections; Section III- discusses about the nanomaterials in artificial scaffolds bone engineering and bone infections caused by bacteria and fungi; and also about the toxicity issues generated by the nanomaterials in general and nanoparticles in particular. The readers will be immensely enriched by the knowledge of new and emerging nanobiotechnologies in a variety of platforms.
    Type of Medium: Online Resource
    Pages: XI, 285 p. 39 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030351472
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Stem cells. ; Hematology. ; Regenerative medicine. ; Biotechnology. ; Stem Cell Biology. ; Hematology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Hematopoietic Stem Cells -- Mesenchymal Stem Cells -- Cord Blood Stem Cells -- Neural Stem Cells and Their Niche -- Skeletal Muscle Stem Cells -- Heart Muscle Tissue Engineering -- Induced Pluripotent Stem Cells -- Epigenetics of Somatic Cell Reprogramming -- Human Pluripotent Stem Cells and Neural Regeneration -- Dopaminergic Neuron-Related Stem Cells -- Liver Disease Modelling -- Organoids in Developmental Biology Research and Application -- Extracellular Vesicles -- Ethics in Stem Cell Applications.
    Abstract: This textbook describes the biology of different stem cell types and outlines the current level of knowledge in the field. It clearly explains the basics of hematopoietic, mesenchymal cord blood, neural and muscle stem cells and also covers induced pluripotent stem cells and their applications. Further, it includes chapters on organoids, stem-cell based disease modelling, extracellular vesicles and one chapter on ethical aspects of human stem cell research, which promotes critical thinking and responsible handling of the material. Based on lectures of the international master program Molecular and Developmental Stem Cell Biology taught at Ruhr-University Bochum and participation of collaborating professors from Tongji University Shanghai, the book is a valuable source for students, postdocs and researchers, who would like to have introductory chapters on stem cell biology. It also offers essential insights for physicians and dentists wishing to expand their knowledge. This textbook is a valuable complement to Concepts and Applications of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.
    Type of Medium: Online Resource
    Pages: XIV, 242 p. 37 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030339234
    Series Statement: Learning Materials in Biosciences,
    DDC: 660.6
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Agriculture. ; Plant biotechnology. ; Plants Development. ; Agriculture. ; Plant Biotechnology. ; Plant Development.
    Description / Table of Contents: Chapter 1. Plant Breeding & Indian Agriculture -- Chapter 2. Plant Breeding & Seed Industry in India -- Chapter 3. Role of Education to Strengthen Plant breeding Capacity -- Chapter 4. Strategies to Strengthen Plant Breeding Status in India.
    Abstract: Plant breeding has the potential to improve quality of life for millions of people, and to harmoniously link agriculture, societies and ecosystems. Global efforts have been made to improve awareness and create a better and brighter future for plant breeding worldwide. Though substantial international research funding is available, and tremendous efforts have been made to achieve food security and sustainability in agriculture, their success can only be ensured when they are complemented by counterparts at the national level. India is ideally poised to reap the benefits of plant breeding by integrating various parameters like adaptation, uncertainty, vulnerability and resilience into agriculture research strategies. Priorities include making agriculture more appealing to young talents, formulating farmer-friendly policies, combining advanced technologies with conventional plant breeding practices, and building the competencies needed to address emerging challenges in agriculture. This book provides an essential overview of modern plant breeding, and demonstrates how education, entrepreneurship training and professional approaches can help transform the image of agriculture from a poor and unattractive domain into a lucrative and business-oriented one. In addition, it presents strategies to help achieve sustainable, accessible and affordable outcomes with breeding programs. The book’s primary goal is to encourage policymakers, academics, private institutions and non-profit organizations to combine their efforts in order to achieve a major transition in plant breeding activities in Asia. Accordingly, it highlights the importance of partnerships and collaborations for making breeding programs more comprehensive and meaningful.
    Type of Medium: Online Resource
    Pages: XIII, 127 p. 24 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811519062
    DDC: 630
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Immunology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Immunology. ; Biomedical Research.
    Description / Table of Contents: Introduction -- Molecular and cellular functions of CTLA-4 pathway -- Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond -- Discovery of new immune checkpoints: family grows up -- Mechanisms of resistance to checkpoint blockade therapy -- Molecular events behind adverse effects -- Rational discovery of response biomarkers -- Spatiotemporal changes in checkpoint molecule expression -- Functions of checkpoint molecules beyond immune evasion -- Genetic alterations and checkpoint expression -- Regulations on messenger RNA: wires and nodes -- Folded or degraded in endoplasmic reticulum -- Mono- and poly-ubiquitination: tags for fates -- Lysosome as the black hole for checkpoint molecules -- Phosphorylation: a fast switch for checkpoint signalling -- Palmitoylation as a signal for delivery -- Checkpoints under traffic control: from and to organelles -- Exosome and secretion: action on? -- Macromolecules and antibody-based drugs -- Mechanisms inspired targeting peptides -- Small molecular inhibitors -- Therapeutic development of immune checkpoint blockers -- Concluding remarks.
    Abstract: This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.
    Type of Medium: Online Resource
    Pages: X, 653 p. 105 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811532665
    Series Statement: Advances in Experimental Medicine and Biology, 1248
    DDC: 571.978
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Regenerative medicine. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Reference search, image & data analysis -- Organ structure & vascularization -- Extracellular matrix & adhesion molecules -- Isolating cells from tissue -- Functional assays & toxicity screening -- Culturing cells in 2D & 3D -- Imaging, staining & markers -- Stems cells & basics of immunology -- Natural & artificial Scaffolds -- Casting & 3D bioprinting -- Bioreactors -- Reporting results -- Index. .
    Abstract: Tissue engineering and regenerative medicine is a new, interdisciplinary branch of science that combines knowledge from numerous scientific fields including biology, biochemistry, physics, chemistry, applied engineering, and medicine. It aims to restore damaged parts of the human body by rebuilding them in vitro using individual building blocks of biological tissues such as cells and the extracellular matrix that surrounds them. The authors hope to spark students’ interest in this exciting new field of science as well as give them a basic knowledge of its terminology. This book is based on a hands-on practical course in tissue engineering conducted by the Fulbright US Scholar recipient, Dr. Narine Sarvazyan (George Washington University, Washington USA). It provides an overview of the core topics of the tissue engineering field, including stem cell differentiation, the role of extracellular matrix and attachment proteins, scaffolds, and culturing of engineered tissues. Each chapter is accompanied by hands-on demonstrations and self-check questions. The text is easily readable for students of all backgrounds and the described protocols can be conducted using common lab equipment. This textbook is also useful for developing undergraduate and graduate courses that teach basic methods and approaches in this promising and rapidly developing field. .
    Type of Medium: Online Resource
    Pages: XXIV, 154 p. 80 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030396985
    Series Statement: Learning Materials in Biosciences,
    DDC: 660.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Stem cells. ; Regenerative medicine. ; Medical genetics. ; Biotechnology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Clinical Genetics. ; Chemical Bioengineering.
    Description / Table of Contents: The future of stem cell research and its clinical translation in Canada: Exploring questions of governance and policy options -- Future cell and gene therapy for osteoarthritis (OA): potential for using mammalian protein production platforms, irradiated and transfected protein packaging cell lines for over-production of therapeutic proteins and growth factors -- The Horizon of Gene Therapy in Modern Medicine: Advances and Challenges -- Developments in Artificial Platelet and Erythroid Transfusion Products -- Advancing mesenchymal stem cell therapy with CRISPR/Cas9 for clinical trial studies -- Mesenchymal Stem Cells in Asthma -- Oocyte Aging: the Role of Cellular and Environmental Factors and Impact on Female Fertility -- Targeting Cancer Metabolism and Cell Cycle by Plant-derived Compounds -- Differentiation potential of Mesenchymal Stem Cells into Pancreatic β-Cells -- Zooming in across the Skin: A Macro-to-Molecular Panorama.
    Abstract: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the eight volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 203 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030458935
    Series Statement: Cell Biology and Translational Medicine, 1247
    DDC: 571.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plants Development. ; Plants Evolution. ; Plant biotechnology. ; Plant physiology. ; Plant genetics. ; Agriculture. ; Plant Development. ; Plant Evolution. ; Plant Biotechnology. ; Plant Physiology. ; Plant Genetics. ; Agriculture.
    Description / Table of Contents: Preface -- Introduction -- 1. The Origin of Potato Production Systems -- 2. Potato Growth and Development -- 3. Variety Selection and Management -- 4. Seed Production and Certification -- 5. Field Selection, Crop Rotations & Soil Management -- 6. Alternative/Organic Management Systems -- 7. Seed and Planting Management -- 8. Nutrient Management -- 9. Disease Management -- 10. Nematode Management -- 11. Insect Pests and Their Management -- 12. Weed Management -- 13. Irrigation Management -- 14. Physiological Disorders -- 15. Tuber Quality -- 16. Harvest Management -- 17. Storage Management -- 18. Principles of Economics and Marketing -- 19. Cost of Production -- 20. Processing and Nutrition -- Index.
    Abstract: This comprehensive guide to potato production systems management contains 20 chapters and more than 350 color photographs. Beginning with the history of potato culture, it spans all aspects of potato production, pest and planting management, storage, and marketing. Written by a team of over 35 scientists from North America, this book offers updated research-based information and serves as a unique, valuable tool for researchers, extension specialists, students, and farm managers. More than a description of principles, it contains practical analytical tools, charts, and methods to create guidelines for best production practices and cost estimates. Some key areas include: Potato Growth and Development, Potato Variety Selection and Management, Seed and Planting Management, Seed Production and Certification, Field Selection, Crop Rotation, and Soil Management, Integrated Pest Management for Potatoes, Potato Nutrient Management, Irrigation Management, Tuber Quality, Economics and Marketing, Production Costs, among others. Potato Production Systems should be a valuable reference for successful culture of the "noble tuber.".
    Type of Medium: Online Resource
    Pages: IX, 635 p. 352 illus., 343 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030391577
    DDC: 571.82
    Language: English
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  • 72
    Keywords: Cytology. ; Stress (Physiology). ; Bioinformatics. ; Cytology Technique. ; Cellular Stress. ; Computational and Systems Biology. ; Cytological Techniques.
    Description / Table of Contents: Introduction -- Assays for thiols and modifications -- Pitfalls of ROS measurements by fluorescent probes and mitochondrial superoxide determination using MitoSOX -- Methods and Reagents -- Clinical Probes for ROS and Oxidative Stress -- Measurement of oxidative stress markers in vitro using commercially available kits -- Oxidative Lipidomics - Analysis of Oxidized Lipids and Lipid Peroxidation in Biological Systems with Relevance to Health & Disease -- Clinically Related Models and Approaches -- Oxidant-Induced Models of Vascular Leak -- Ozone-Specific’ Oxysterols and Neuronal Cell Signaling -- Measurement Oxidative Stress Status in Human Populations: A Critical Need for a Metabolomic Approach -- Instrumental Methods -- Sense and Sensibility of Oxygen in Pathophysiology using EPR Oximetry -- Resonators for Clinical EPR -- Biomedical Overhauser Magnetic Resonance Imaging (OMRI). Noninvasive Imaging of Redox Processes -- Index.
    Abstract: This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
    Type of Medium: Online Resource
    Pages: XIV, 237 p. 85 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030473181
    Series Statement: Biological Magnetic Resonance, 34
    DDC: 571.6
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Biochemistry. ; Internal medicine. ; Lipids. ; Bioinformatics. ; Medical genetics. ; Biomedical Research. ; Chemical Biology. ; Internal Medicine. ; Lipidology. ; Computational and Systems Biology. ; Medical Genetics.
    Description / Table of Contents: Sterols from the post-lanosterol part of cholesterol synthesis – novel signaling players -- Genetic variability in cholesterol metabolism -- Side-chain oxidized oxysterols in health and disease -- Bile acids and TGR5 (Gpbar1) signaling -- Bile acids as regulatory signalling molecules -- Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: nuclear receptors LXR, FXR, and fibroblast growth factor 15/19 -- Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids.
    Abstract: This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as medical doctors in hepatology.
    Type of Medium: Online Resource
    Pages: V, 171 p. 57 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030396848
    DDC: 610.72
    Language: English
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  • 74
    Keywords: Fungi. ; Mycology. ; Microbiology. ; Agriculture. ; Plants Evolution. ; Plant biotechnology. ; Plants Development. ; Fungi. ; Agriculture. ; Plant Evolution. ; Plant Biotechnology. ; Plant Development.
    Description / Table of Contents: Preface -- Introduction to Agriculturally Important Fungi for Crop Protection -- Role of Fungi in Adaptation of Agriculture Crops to Abiotic Stresses -- Arbuscualr Mycorrhizae Associations and Role in Mitigation of Drought Stress in Plants -- Fungal Mediated Alleviation of Cold Stress for Growth and Yield of Cereal Crops -- Soil Salinity and their Alleviation Using Plant Growth Promoting Fungi -- Phytohormones Producing Fungal Communities -- Fungal Secondary Metabolites and Bioactive Compounds for Plant Defence -- Fungal Endophytes -- Aspergillus Mycotoxins -- Trichoderma -- Piriformospora indica -- Bioresources for Control of Plant Parasitic Nematodes -- Global Scenario of Advance Fungal Research in Biocontrol and Crop Protection -- Index -- .
    Abstract: Microbes are ubiquitous in nature. Among microbes, fungal communities play an important role in agriculture, the environment, and medicine. Vast fungal diversity has been found in plant systems. The fungi associated with any plant system are in the form of epiphytic, endophytic, and rhizospheric fungi. These associated fungi play important roles in plant growth, crop yield, and soil health. The rhizospheric fungi present in rhizospheric zones have a sufficient amount of nutrients released by plant root systems in the form of root exudates for growth, development, and activities of microbes. Endophytic fungi enter in host plants mainly through wounds that naturally occur as a result of plant growth, or develop through root hairs and at epidermal conjunctions. The phyllospheric fungi may survive or proliferate on leaves, depending on the extent of influences of material in leaf diffuseness or exudates. The diverse group of fungal communities is a key component of soil-plant systems, where they are engaged in an intense network of interactions in the rhizospheric, endophytic, and phyllospheric areas, and they have emerged as an important and promising tool for sustainable agriculture. These fungal communities help to promote plant growth directly or indirectly by mechanisms for plant growth-promoting (PGP) attributes. These PGP fungi can be used as biofertilizers, bioinoculants, and biocontrol agents in place of chemical fertilizers and pesticides in an environmentally and eco-friendly manner. This book covers the current knowledge of plant-associated fungi and their potential biotechnological applications in agriculture and allied sectors. This book should be useful to scientists, researchers, and students of microbiology, biotechnology, agriculture, molecular biology, environmental biology, and related subjects.
    Type of Medium: Online Resource
    Pages: XVIII, 370 p. 40 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030484743
    Series Statement: Fungal Biology,
    DDC: 579.5
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Surgery. ; Blood-vessels Surgery. ; Neurology . ; Neurosurgery. ; Vascular Surgery. ; Neurology.
    Description / Table of Contents: Brief History of Cavernous Malformations -- Definition and structure of cerebral cavernous malformations -- Molecular Biology of CCM -- Presentation -- Neuroimaging of Cerebral Cavernous Malformations -- Natural history of cavernous malformations -- Hemispherical Cavernomas in non-eloquent and eloquent areas -- Cavernoma-Related Epilepsy -- Surgery of deep-seated cavernous malformations -- Surgery of brainstem and cerebellar cavernous malformations -- Stereotactic Radiosurgery of Cavernous Malformations -- Cavernomas in children -- Cavernomas During Pregnancy -- Spinal cavernous malformations -- Intraorbital cavernous malformations.
    Abstract: This book presents a complete up-to date description of cavernoma disease together with its known biology, genetics and variable clinical presentation. It facilitates improved decision-making on surgical intervention by presenting different cases, highlighting the particular features of lesions such as anatomical location, eloquences of adjacent brain and type of presentation that are important when making decisions. In addition, the reader is brought up to speed with developments in the neuroimaging and active treatment techniques, especially surgical resection and radiosurgery. Finally, the natural history of the disease is taken into account and compared to the possible benefits of surgical treatment. Cavernomas of the CNS: Basic Science to Clinical Practice provides a comprehensive overview from the fundamentals of this condition, to special patient groups such as children and pregnant women. Therefore, it is an indispensable resource for neurovascular surgeons, neurosurgical residents and neurologists.
    Type of Medium: Online Resource
    Pages: VIII, 245 p. 124 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030494063
    DDC: 617.48
    Language: English
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  • 76
    Keywords: Conservation biology. ; Ecology . ; Animal migration. ; Biodiversity. ; Food science. ; Conservation Biology. ; Animal Migration. ; Biodiversity. ; Food Science.
    Description / Table of Contents: Part I. Introduction and Background -- Introduction: Starting the Journey to a Sustainable Ecosystem and Healthy People -- The Bay and Its Watershed: A Voyage Back in Time -- Scientific Concepts for Understanding the health of the Chesapeake Bay and its people -- Part II. Foundations of the Chesapeake Bay Food System and the Consequences of Over-Extraction -- The Algonquin Food System and how it Shaped the Ecosystem and Interactions with the English Colonists of the Chesapeake Bay -- A Fishing Trip: Exploiting and managing the commons of the Chesapeake Bay -- Menhaden, the Inedible Fish that Most Everyone Eats -- Blue Crabs: Beautiful Savory Swimmers of the Chesapeake Bay -- The Chesapeake Bay Oyster: Cobblestone to Keystone -- Passenger Pigeon and Waterfowl: Flights to Extinction and Not -- Part III. Industrial-chemical Agriculture Reshapes the Bay’s Ecosystem -- The journey from Peruvian Guano to Artificial Fertilizer ends with too Much Nitrogen in the Chesapeake Bay -- Pesticides bring the War on Nature to The Chesapeake Bay -- Livestock and Poultry: the Other Colonists who Changed the Food System of the Chesapeake Bay -- Part IV. Consequences of and Alternatives to the Standard American Diet: Human and Ecosystem Health -- Instead of Eating Fish: the Health Consequences of Eating Seafood from the Chesapeake Bay Compared to Other Choices -- Sugar Twice Enslaves: Consequences for the People of the Chesapeake -- Eutrophication: Obesity of the Bay and its People -- Finishing the Journey: Urine and Feces as Misplaced Resources -- Plastic Food System Waste Travels Far but Never Goes Away -- Part V. Looking to the Future: Ecology, Economics, Ethics, and Policy for Restoring the Health of the Bay and its People -- A New Food System for The Chesapeake Bay Region and a Changing Climate -- An Organic-Based Food System: A Voyage Back and Forward in Time -- What Nature, Politics and Policy Demand of the Chesapeake Bay and its Food System -- Ethics and Economics of Building a Food System to Recover the Health of the Chesapeake Bay and its People.
    Abstract: This book explores a specific ecosystem in depth, in order to weave a story built on place and history. It incorporates the theme of a journey to help reveal the environment-human-health-food system-problem. While drawing on a historical approach stretching back to the American colonial era, it also incorporates more contemporary scientific findings. By crafting its story around a specific place, the book makes it easier for readers to relate to the content, and to subsequently use what they learn to better understand the role of food systems at the global scale.
    Type of Medium: Online Resource
    Pages: XIV, 430 p. 240 illus., 198 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030454814
    Series Statement: Estuaries of the World,
    DDC: 333.9516
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Agriculture. ; Applied ethics. ; Soil science. ; Environment. ; Agriculture. ; Agricultural Ethics. ; Soil Science. ; Environmental Sciences.
    Description / Table of Contents: 1. Introduction -- 2. From Weed Control To Ethics -- 3. Agriculture- A Brief History -- 4. World Population - Three Views -- 5. Agricultures Moral Dilemmas -- 6. Ethics in Agriculture and Other Disciplines -- 7. Seeking Common Ground -- 8. Ethical Puzzles.
    Abstract: I write because I am concerned that I and my agricultural colleagues have avoided addressing the moral dimension of the environmental and social problems we have contributed to. I hope for an exchange of ideas about agriculture's moral dilemmas. I encourage my readers to engage in a collective conversation about the dilemmas and avoid remaining in what Merton calls "the collective arrogance and despair of his own herd." If those engaged in agriculture continue to ignore and fail to realize our common difficulties they will be addressed and resolved by societal pressure and political action, which may not yield the resolution we favor. The book's goal is not to resolve the moral dilemmas raised. It is to raise them and encourage thought and discussion. It will ask but not answer why nearly all involved in agriculture have not addressed the moral concerns voiced by the general public. The agricultural enterprise is committed to the benefits and future success of the present, very productive, chemical, capital, and energy intensive system, which is, in the minds of many, not sustainable. The internal justification invokes the moral claim that they feed the world's population. The question remains whether or not the prevailing moral justification of feeding the world is adequate given all the issues modern, developed country agriculture faces: pesticides in soil, water, and food, cruelty to animals, Biotech/GMO's, corporate agriculture, pollution by animal factory waste, exploitation of and cruelty to migrant labor.
    Type of Medium: Online Resource
    Pages: XI, 173 p. 2 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030489359
    DDC: 630
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Forensic sciences. ; Medical jurisprudence. ; Pharmacology. ; Forensic Science. ; Forensic Medicine.
    Description / Table of Contents: Part 1: Introduction -- Post Mortem Forensic Toxicology -- Human Performance Toxicology -- Drug-Facilitated Sexual Assault -- Forensic Drug Testing -- Performance enhancing Drug Testing -- Drug Testing in Pain Management -- Pharmacokinetics and Pharmacodynamics -- Part II. Specimen Preparation -- Spectrophotometry -- Chromatography -- Derivatization -- Immunoassy -- Mass Spectrometry -- Quantitation -- Method Validation -- Measurement Uncertainty and Traceability -- Statistics in Forensic Toxicology -- Part III Analytes -- Alcohol -- Benzodiazapines -- Gammahydroxybutyric acid,- Miscellaneous Central Nervous System Depressants -- Opioids -- Cocanie -- Cannabis -- Amphetamines-Sympathomimetic Amines,- Hallucinogens and Psychedelics -- Antidepressants and Neuroleptics -- Miscellaneous Therapeutic Drugs -- Carbon Monoxide/Cyanide -- Inhalants -- Metals -- Part III Special Topics -- Stability of Drugs of Abuse in Biological Systems -- Postmortem Redistribution of Drugs -- Postmortem Clinical Testing -- Pharmacogenomics -- Hair Drug Testing -- Oral Fluid Testing -- Meconium Drug Testing -- Drugs in Embalmed Tissues.
    Abstract: The fifth edition of the best-selling Principles in Forensic Toxicology continues in the tradition of excellence in academic publishing. With over 10 years of classroom-tested and continually updated content, the new edition contains significant updates and 7 new chapters on new topics including drug-facilitated crimes, derivatization, quantitation, measurement uncertainty/traceability, statistics, oral fluid testing, and drugs in embalmed specimens. Part One covers the major sub-disciplines of forensic toxicology in addition to pharmacological concepts. Part Two addresses specimen preparation, laboratory testing and instrumental analysis, while Part Three discusses common analytes including cocaine, opioids, alcohol, and marijuana. Adopted for courses in many of the top universities for forensic science and used by respected medical examiner’s offices and crime laboratories worldwide, Principles of Forensic Toxicology prepares the next generation of forensic toxicologists and continues to be an important reference in professional practice.
    Type of Medium: Online Resource
    Pages: XIII, 691 p. 188 illus., 23 illus. in color. , online resource.
    Edition: 5th ed. 2020.
    ISBN: 9783030429171
    DDC: 615
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Telecommunication. ; User interfaces (Computer systems). ; Human-computer interaction. ; Application software. ; Industrial engineering. ; Production engineering. ; Computational and Systems Biology. ; Communications Engineering, Networks. ; User Interfaces and Human Computer Interaction. ; Computer and Information Systems Applications. ; Industrial and Production Engineering.
    Description / Table of Contents: Introduction -- Emerging Industrial Revolution -- IoT: What makes it different from the past revolutions -- World is changing -- Engineering: How It was developed so far -- Humans: Their characteristics -- Value is changing -- Adaptive team organization and management -- Integration of Physical Science and Life Science -- Summary.
    Abstract: .
    Type of Medium: Online Resource
    Pages: XI, 70 p. 44 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030515881
    Series Statement: SpringerBriefs in Applied Sciences and Technology,
    DDC: 570.285
    Language: English
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  • 80
    Keywords: Immunology. ; Immunology.
    Description / Table of Contents: 1. Core Concepts in Immunology: The Definition of Autoimmunity and Its Unique Application to the Seat of Tolerance, the Liver -- 2. The Liver as a Lymphoid Organ -- 3. The Uniqueness of Innate Immunity -- 4. Adaptive Immunity and the Clinical Definition of Autoantibodies.-5. Genetics of Autoimmune Liver Diseases -- 6. The Epigenetic Basis of Loss of Tolerance -- 7. Bile Acids and Bilirubin in Liver Immunology -- 8. The Microbiota-Gut-Liver Axis – Implications for the Pathophysiology of Liver Disease -- 9. Diagnostic Liver Immunology -- 10. The Pathologist’s Approach to Reviewing Liver Histology -- 11. Geoepidemiology of Autoimmune Liver Diseases -- 12. Immune Responses to Bacterial Infections -- 13. Immunity of Parasitic Infections of the Liver -- 14. The Treatment of Bacterial and Parasitic Diseases of the Liver -- 15. Hepatitis A and Other Viral Infections -- 16. Hepatitis B Virus -- 17. Hepatitis C -- 18. Hepatitis D -- 19. Hepatitis E -- 20. Alcohol-Associated Liver Disease -- 21. Non-alcoholic Fatty Liver Disease: A Chapter in Liver Immunology -- 22. Primary Biliary Cholangitis -- 23. PSC – AIH Overlap -- 24. Primary Biliary Cholangitis: Autoimmune Hepatitis Overlap Syndrome -- 25. Primary Sclerosing Cholangitis -- 26. Autoimmune Hepatitis -- 27. IgG4-related Disease: Current Concept, Diagnosis, and Pathogenesis -- 28. Pediatric Liver Disease -- 29. Mechanisms of Acute Liver Failure -- 30. Immune-Mediated Drug-Induced Liver Injury -- 31. Hepatobiliary Cancers and Immunology -- 32. Acute-on-Chronic Liver Failure -- 33. The Pathogenesis of Liver Diseases in Pregnancy -- 34. Graft-Versus-Host Disease -- 35. Immunopathogenesis of Liver Cirrhosis -- 36. Immune-Mediated Liver Disease in the Transplanted Liver.
    Abstract: The third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases. Developed by a panel of renowned international authors, this edition outlines a range of important advances in our understanding of the liver’s role as an immune organ and the functions of innate and adaptive immunity in the pathogenesis of all liver diseases. Indeed, the liver is a vitally important immune organ producing liver-derived products that can trigger the innate and adaptive immune system to initiate, mediate, regulate, and resolve systemic inflammation. The book begins with an analysis of the core concepts of immunology, including the definition of autoimmunity and its unique application to the liver, a tolerogenic organ. Subsequent chapters then explore the biological elements of liver diseases caused by epigenetics, genetics, and innate and adaptive immunity. Specific clinical presentations and aspects of liver diseases are also examined, such as Hepatitis C, non-alcoholic fatty liver disease and parasitic infections. Closing chapters then discuss liver diseases among specific populations, including pediatrics, those with comorbidities and preexisting conditions, pregnant women, and finally patients with transplanted organs. A timely and invaluable update to the clinical literature, Liver Immunology: Principles and Practice, Third Edition, is once again a comprehensive work that will not only enhance the understanding of liver diseases but also provide the kind of novel insights that greatly accelerates the evidence-based care of children and adults afflicted with these diseases. This volume is again a must-read for clinicians at all levels, for investigators and for students. .
    Type of Medium: Online Resource
    Pages: XV, 633 p. 145 illus., 135 illus. in color. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783030517090
    DDC: 571.96
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Surgery. ; Neurology . ; Radiology. ; Pediatrics. ; Neurosurgery. ; Neurology. ; Radiology. ; Pediatrics.
    Description / Table of Contents: I Overview -- 1 Historical landmarks in pineal region surgery -- 2 Pineal region anatomy -- 3 Pathology of Pineal Region Lesions -- 4 Clinical presentation -- 5 Imagistic diagnosis -- 6 The Usefulness of Biomarkers for Diagnosis -- 7 Surgical Adjuvants for pineal region approach -- II Surgical approaches for pineal region lesions -- 8 Supracerebellar infratentorial approach -- 9 Occipital transtentorial approach -- 10 Transcallosal approach -- 11 Endoscopic approaches for pineal region lesions -- 12 Management of Hydrocephalus -- III Adjuvant therapies -- 13 Radiosurgery -- 14 Other radiotherapeutic techniques -- 15 Chemotherapy -- IV Pineal region tumors -- 16 Tumors of Pineal Cell Origin -- 17 Tumors of germ cell origin -- 18 Tumors of glial origin -- 19 Meningiomas of the pineal region -- 20 Metastatic tumors -- V Vascular lesions of the pineal region -- 21 Arterio-venous malformations -- 22 Cavernomas.-23 Vein of Galen Aneurismal Malformation -- VI Cysts and Cyst -Like Lesions of the pineal region -- 24 Epidermoids and Dermoids -- 25 Pineal Cyst -- VII Miscellanea -- 26 Management algorithms -- 27 Conclusions.
    Abstract: Neurosurgical lesions of the pineal region are extremely rare, accounting for roughly 1% of the total number of neurosurgical expansive lesions in modern practice. This book offers an up-to-date review of the relevant literature, combined with the personal perspectives of some highly experienced figures in the field. The book is divided into two main parts, the first of which offers an overview of the pineal region from an anatomic, pathologic, imaging and therapeutic perspective. Special attention is given to surgical approaches to pineal region lesions. Microsurgical techniques are presented, together with detailed indications regarding specific locations of these lesions, specific complications, and controversial aspects concerning some of the approaches. A dedicated chapter addresses endoscopic techniques, their indications and limitations. Adjuvant therapies are also discussed, along with their particular indications and debated aspects. In turn, the chapters in the second part cover specific lesions such as pineal region tumors, vascular lesions, and cystic and cyst-like lesions. Regarding pineal region tumors, the most frequent pathologies are presented in the most comprehensive and practical manner possible, with special attention to the appropriate therapeutic management for each type. Further, there is a dedicated chapter on pineal region cysts. Given its depth of content, the book will allow neurosurgeons and specialists to greatly expand their understanding of pineal region lesions in daily clinical practice.
    Type of Medium: Online Resource
    Pages: XI, 260 p. 113 illus., 82 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030509132
    DDC: 617.48
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Statistics . ; Biometry. ; Biomedical Research. ; Applied Statistics. ; Biostatistics.
    Description / Table of Contents: Design of Clinical Research and its Practical Approach -- Advanced Design of Experiment Approach to Clinical and Medical Research -- Random Forest and Concept of Decision Tree Model -- Application of Machine Learning in Medical Research -- Statistical Genetic and its Application in Drug Trail -- Statistical Implications for Estimation of Genetic Traits in Human Vaccine Trail -- Statistical Implications and its Practical Approach to Research Methodology -- Statistical Models Approach to Life Threatened Diseases -- Meta Analysis in Clinical and Life Science Research -- Pharmokinitic and Statistical Modelling -- Imputation Methods Approach to Clinical and Life Science Research Data Sets -- Ethical Perspective of Medical Research.
    Abstract: Recent Statistical techniques are one of the basal evidence for clinical research, a pivotal in handling new clinical research and in evaluating and applying prior research. This book explores various choices of statistical tools and mechanisms, analyses of the associations among different clinical attributes. It uses advanced statistical methods to describe real clinical data sets, when the clinical processes being examined are still in the process. This book also discusses distinct methods for building predictive and probability distribution models in clinical situations and ways to assess the stability of these models and other quantitative conclusions drawn by realistic experimental data sets. Design of experiments and recent posthoc tests have been used in comparing treatment effects and precision of the experimentation. This book also facilitates clinicians towards understanding statistics and enabling them to follow and evaluate the real empirical studies (formulation of randomized control trial) that pledge insight evidence base for clinical practices. This book will be a useful resource for clinicians, postgraduates scholars in medicines, clinical research beginners and academicians to nurture high-level statistical tools with extensive scope.
    Type of Medium: Online Resource
    Pages: XXXV, 356 p. 190 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811582103
    DDC: 610.72
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Human physiology. ; Medicine Research. ; Biology Research. ; Gynecology . ; Cancer Biology. ; Human Physiology. ; Biomedical Research. ; Gynecology.
    Description / Table of Contents: Preface -- PART 1: Basic Considerations -- Anatomy and Physiology of the Breast during Pregnancy and Lactation -- Diagnosis of Breast Disorders in Pregnancy and Lactation -- Clinical Presentations of Breast Disorders in Pregnancy and Lactation -- PART 2: Benign and Premalignant Disorders of the Breast in Pregnancy and Lactation -- Benign Disorders of the Breast in Pregnancy and Lactation -- Mastitis, Breast Abscess, and Granulomatous -- Premalignant disorders of the Breast in Pregnancy and Lactation -- PART 3: Breast Cancer in Pregnancy and Lactation -- Epidemiology of Pregnancy-Associated Breast Cancer -- Histology of Pregnancy-Associated Breast Cancer -- Clinical presentation, Diagnosis, and Prognosis of Pregnancy-Associated Breast Cancer -- . Treatment of Pregnancy-Associated Breast Cancer -- Special Clinical Situations -- Prenatal Care during and after Breast Cancer Treatment -- Lactation during and after Breast Cancer -- Pregnancy in Breast Cancer Survivors. Impact of Breast Cancer Treatment on Fertility -- Fertility Counseling and Preservation for Breast Cancer Patients -- Pregnancy after Breast Reconstruction -- Pregnancy and Lactation: Risk or Protective Factors for Breast Cancer -- Psychological Aspects of Pregnancy and Lactation in Patients with Breast Cancer.
    Abstract: Symptoms of the breast in gravid women commonly represent physiological changes, however they may also be related to serious underlying breast disease; this challenging dilemma is aggravated by diagnostic and therapeutic limitations imposed by safety issues regarding the mother and fetus. A comprehensive coverage of all aspects of normal and pathologic breast changes during pregnancy and lactation, their diagnosis and management is provided in the present work. The organized structure of this book begins with gestational changes of the breast, while discussing safety, hazards, and arguments regarding diagnostic approaches. It then goes on by describing various clinical presentations and common and uncommon benign disorders during gravidity. The book then addresses pre-malignant lesions of the breast, opening the dialogue on how to manage these confusing lesions in pregnant and nursing women. It continues toward pregnancy-associated breast cancer, focusing on every facet of the problem, including epidemiology, diagnosis, treatment and complications, anesthetic considerations, prenatal care, and rare malignancies; and comes to an end by arguing main psychological concerns. In the midst of this orderly sequence fertility issues, pregnancy, and breastfeeding in women who have overcome their breast cancer are also discussed. This unique reference has been written by academic experts from different centers and diverse disciplines in a practical format. It is intended to be an ideal resource for every practitioner and specialist who manages complaints of gravid and nursing women or treats breast disorders in women of child bearing age.
    Type of Medium: Online Resource
    Pages: XXV, 216 p. 55 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030415969
    Series Statement: Advances in Experimental Medicine and Biology, 1252
    DDC: 571.978
    Language: English
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  • 84
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Respiratory organs. ; Physiology. ; Epidemiology. ; Human Physiology. ; Respiratory Physiology. ; Epidemiology.
    Description / Table of Contents: Nosocomial Infections in Patients Hospitalized with Respiratory Syncytial Virus: A Practice Review -- Regional Activity and Spread of Influenza Viruses in Poland in the Context of Neighboring Countries in the Epidemic Season 2017/18: An Epidemiological Review -- Bacteremia in Children Hospitalized Due to Respiratory Syncytial Virus Infection -- Multi-Spectral Pattern of Clinical Presentation and the Resultant Outcome in Central Nervous System Tuberculosis: A Single Center Audit on the Ubiquitous Pathogen -- Adherence to Therapy in Chronic Obstructive Pulmonary Disease: A Systematic Review -- How Healthy Is Healthy? – Comparison between Self-Reported Symptoms and Clinical Outcomes in Connection with the Enrollment of Volunteers for Human Exposure Studies on Sensory Irritation Effects -- Coexpression of Hsp70 Protein and Autophagy Marker Protein LC3 in A549 C ells and THP1 Cells Exposed to Nanoparticles of Air Pollution -- Whole Blood Assay as a Tool to Describe the Effects of Zinc Oxide Exposure on Innate Immunity -- Depression and Serum Content of Serotonin in Adult Patients with Atopic Dermatitis -- Evaluation of Nocturnal Respiratory Complaints in Pregnant Women -- Cardiovascular Function in Obstructive Sleep Apnea Patients with Controlled Hypertension -- Diagnosis of Sleep-Disordered Breathing in the Home Environment.
    Abstract: This book shares the experimental findings and views in current multidisciplinary medical science combining both basic and applied research aimed at resolving problematic health issues. The key topics address contagious diseases, in particular the epidemiology, clinical presentation, and management of influenza and influenza-like infections as well as brain tuberculosis. Pulmonary medicine is represented by articles addressing a range of practical issues, including the diagnosis, symptoms, comorbidities, and treatment of obstructive sleep apnea, a syndrome whose incidence shows a persistent upward trend worldwide. Other articles address the pathogenesis of air pollution toxicity and allergy and sensory irritation in toxic exposure studies. An intriguing relation of atopic dermatitis to depression and serotoninergic system is debated. The book attempts to integrate research into clinical work and to implement findings to improve care and to decrease suffering from diseases. It is dedicated to the practicing professionals, researchers, and all engaged in health care.
    Type of Medium: Online Resource
    Pages: VI, 112 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504984
    Series Statement: Clinical and Experimental Biomedicine, 1271
    DDC: 612
    Language: English
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  • 85
    Keywords: Agriculture. ; Botanical chemistry. ; Microbial ecology. ; Plant physiology. ; Microbiology. ; Agriculture. ; Plant Biochemistry. ; Microbial Ecology. ; Plant Physiology. ; Microbiology.
    Description / Table of Contents: Chapter 1. Phytobiomes: role in nutrient stewardship and soil health -- Chapter 2. Role of a quorum sensing signal, acyl-homoserine lactone in a phytobiome -- Chapter 3. Plant Microbiomes: Understanding the Above Ground Benefits -- Chapter 4. Plant Mycobiome: Current Research and Applications -- Chapter 5. Role of Soil Fauna: en route to Ecosystem Services and its effect on soil health -- Chapter 6. An insight into current trends of pathogen identification in plants -- Chapter 7. Linkages of Microbial Plant Growth Promoters towards the Profitable Farming -- Chapter 8. Wheat microbiome: present status and future perspective -- Chapter 9. Entomopathogenic Fungi: A potential source for biological control of insect pests -- Chapter 10. Role of microbiotic factors against the soil-borne phytopathogens -- Chapter 11. Zinc solubilizing microbes for sustainable crop production: Current understanding, opportunities, and challenges -- Chapter 12. Endophytic phytobiomes as defense elicitors: current insights and future prospectus -- Chapter 13. Role of biotechnology in the exploration of soil and plant microbiomes -- Chapter 14. Plant parasitic nematodes management by phytobiomes and application of fly ash -- Chapter 15. Phytobiome Engineering and its impact on Next Generation Agriculture.-.
    Abstract: To satisfy the food demands of the global population, advanced technology based research is needed, that can extract the information from the plant metabolism and microbial gene pool and use it for improving plant health and productivity. Modern biotechnological tools have the ability to unlock the limitations of agricultural practices. However, the application of these tools is not well equipped. Moreover, eco-friendly agriculture by microbial inoculants is known to have positive influences on soil/plant health. Therefore it is relevant to explore the plant associated microbial niches, especially endophytes, epiphytes, and soil microbes and understand how they are benefitting each other. It can open new insights to develop sustainable agriculture practices by using consortia of microbes as plant helpers that recover the imbalanced agriculture systems and manage pathogenic diseases. This book presents the updates about the plant associated microbiomes and their contemporary uses. It covers the knowledge gap between soil and plant helper microbiomes and their application in the agriculture and allied sectors. Modern insights of phytobiomes are explored in various chapters on a variety of interrelated aspects of the fascinating areas like plant microbial interaction, integrated pest management, soil fertility intensification, sustainable crop production, and disease management. Sections in the book describe how to plant beneficial microbiomes have been utilized for sustainable green farming, with the aim to resolve the global food problem without harming the soil and environment health. This book is intended for everyone who is involved in agriculture, microbial biotechnology, bioinformatics, and all disciplines related to microbial biotechnology. These include academic students, scientists, and researchers at universities, institutes, industries, and government organizations who want to understand microbial linkages in a shorter time. It contains basic information that will be help to the non-specialist readers to understand progressive research.
    Type of Medium: Online Resource
    Pages: X, 403 p. 39 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811531514
    DDC: 630
    Language: English
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  • 86
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Molecular genetics. ; Cancer. ; Genetics. ; Biochemistry. ; Biological transport. ; Cell membranes. ; Molecular Genetics. ; Cancer Biology. ; Genetics and Genomics. ; Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: 1. History of sialic acids, gangliosides and GM3 -- 2. Synthesis of GM3 -- 3. Molecular localization of GM3 in cells -- 4. Basic function of GM3 as an interacting molecule -- 5. GD3 mimetics with a neurite forming capacity -- 6. GM3 as a pathogenic infection receptor -- 7. GM3 and related gangliosides prevent inflammation and atherosclerosis -- 8. GM3 has an anti-tumor capacity -- 9. GM3 suppresses tumor angiogenesis -- 10. Interaction between EGFR and GM3 -- 11. Membrane ganglioside-specific neuraminidase 3 (NEU3) regulates GM3 signaling -- 12. Regulation of GM3-mediated EGFR signaling by NEU3 sialidase -- 13. VEGFR-GM3 interaction in angiogenesis -- 14. GM3, competing with GM1, interaction with urokinase plasminogen activator receptor (uPAR) in endothelial caveolar-lipid rafts inhibits angiogenesis -- 15. GM3 interacts with TGFβ Rs in the epithelial-mesenchymal transition (EMT) during posterior capsular opacification (PCO) formation -- 16. Galectin-1 promotes tumor growth and escapes immune surveillance -- 17. GM3-HGFR, FGFR and PDGFR cancer cell behavior, and IGF-1R in diabetic wound healing -- 18. GM3, caveolin-1 and insulin receptor in insulin resistance -- 19. GM3 suppresses arthritis -- 20. GM3 protects cochlear hair cells and hearing from corti degeneration -- 21. GM3 increases osteoclast differentiation via direct GM3 cooperation with RANKL and IGF-1 -- 22. GM3 in leukemic cells into terminal differentiation -- 23. α2,3-Sialyllactose (3SL) or α2,6-sialyllactose (6SL) of GM3 glycan in innate immunity. .
    Abstract: This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field.
    Type of Medium: Online Resource
    Pages: VII, 138 p. 32 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811556524
    DDC: 572.8
    Language: English
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  • 87
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    Cham :Springer International Publishing :
    Keywords: Immunology. ; Pharmacology. ; Diseases. ; Cancer. ; Immunology. ; Pharmacology. ; Diseases. ; Cancer Biology.
    Description / Table of Contents: 1. Human Chronic Viruses: Pathogenesis, host response, and treatment -- 2. Defining the Role of Immunoproteomics in Human Immunotherapy -- 3. Microbiome and Cellular Players in Type 1 Diabetes: from Pathogenesis to Protection -- 4. Immune Mechanisms, Pathology, and Management of Allergic Ocular Diseases -- 5. Dendritic Cell-regulated T Cell Immunity and Tolerance against Acute Myeloid Leukemia -- 6. Perspectives on the Role of T cell Negative Immune Checkpoint Receptors in Health and Disease -- 7. Neuroprotective Immunity for Neurodegenerative and Neuroinfectious Diseases -- 8. Polycystic Ovary Syndrome: An overview of a complex, heterogeneous genetic condition.
    Abstract: This book highlights information derived primarily from clinical samples, with particular reference to theoretical and scientific aspects of the human immune system. This text will focus on topics that range from host-pathogen interactions in infectious disease to host immune response in cancer, allergic diseases, neuroinflammatory diseases, and autoimmune disorders. The reader will also have a well-rounded understanding of the behavior of the immune system with particular emphasis on the role of immunoproteomics in immunotherapy, neuroprotective immunity for neurodegenerative and neuroinfectious disease, leukemia-associated dendritic cell induction of adaptive immunity dysregulation, and the role of immune checkpoint inhibitors in cancer, infection, as well as neuroinflammation. Taken together, the contents of this book are intended for both clinicians and researchers in academia and industry.
    Type of Medium: Online Resource
    Pages: XVIII, 403 p. 16 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030339463
    DDC: 571.96
    Language: English
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  • 88
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Medical sciences. ; Pharmacology. ; Biomedical Research. ; Cell Biology. ; Health Sciences. ; Pharmacology.
    Description / Table of Contents: Autophagy and Alzheimer’s Disease -- Autophagy and Parkinson’s Disease -- Autophagy and Motor Neuron Diseases -- Autophagy and Prion Disease -- Autophagy and Lysosome Storage Disorders -- Autophagy and Mitochondrial Encephalomyopathies -- Autophagy and Ischemic Stroke -- Autophagy and Hemorrhagic Stroke -- Autophagy and Polyglutamine Disease -- Autophagy and Epilepsy -- Autophagy in Neurodevelopmental Disorders -- Autophagy and Pituitary Adenoma -- Autophagy in Schizophrenia -- Autophagy and Hypertension -- Autophagy and Myocardial Ischemia -- Autophagy and Heart Failure -- Autophagy, Myocarditis and Cardiomyopathy -- Autophagy, Hyperlipidemia and Atherosclerosis -- Application of Autophagy in Cardiovascular Diseases -- Autophagy and Tumorigenesis -- Autophagy and Tumour Stem Cells -- Autophagy and Tumour Metastasis -- Autophagy and Tumor Cell Death -- Autophagy and Tumour Chemotherapy -- Autophagy and Tumour Radiotherapy -- Autophagy and Inflammatory Diseases -- Autophagy and Immune-related Diseases -- Autophagy and Autoimmune Diseases -- Autophagy and Bacterial Infection -- Autophagy and Viral Infection -- Autophagy and Thyroid Disease -- Autophagy and Obesity and Diabetes -- Autophagy and Obesity-related Reproductive Dysfunction -- Autophagy and Acute Kidney Injury -- Autophagy and Glomerular Diseases -- Autophagy and Diabetic Nephropathy -- Autophagy and Liver Diseases -- Autophagy and Gastrointestinal Diseases -- Chronic Obstructive Pulmonary Disease and Autophagy -- Autophagy and Pulmonary Fibrosis -- Asthma and Autophagy -- Autophagy and Other respiratory diseases -- Autophagy and Leukemia -- Autophagy and Lymphoma -- Autophagy and Myeloma -- The Function and Mechanisms of Autophagy in Traumatic Brain Injury -- The Function and Mechanisms of Autophagy in Spinal Cord Injury -- The Function and Mechanisms of Autophagy in Trauma of Other Parts of the Body -- The Prospects of Therapeutic Potential and Drug Development Targeting Autophagy in Cancer -- Progress of Anti-aging Drugs Targeting Autophagy -- Drug Development and Treatment of Autophagy in Other Diseases -- Systems Biology Approaches in Autophagy Research -- Natural Product Regulates Autophagy in Cancer -- Regulation of Autophagy in Neurodegenerative Diseases by Natural Products -- Regulation of Autophagy in Cardiovascular Diseases by Natural Products.
    Abstract: This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine.
    Type of Medium: Online Resource
    Pages: XXXVI, 736 p. 50 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811542725
    Series Statement: Advances in Experimental Medicine and Biology, 1207
    DDC: 610.72
    Language: English
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  • 89
    Keywords: Plant physiology. ; Agriculture. ; Plant biotechnology. ; Plant genetics. ; Botanical chemistry. ; Climatology. ; Plant Physiology. ; Agriculture. ; Plant Biotechnology. ; Plant Genetics. ; Plant Biochemistry. ; Climate Sciences.
    Description / Table of Contents: 1.The Plant Family Brassicaceae: Introduction, Biology and Importance -- 2. Agricultural, Economic and Societal Importance of Brassicaceae Plants -- 3.Arabidopsis thaliana: Model Plant for the Study of Abiotic Stress Responses -- 4. Newly Revealed Promising Gene Pools of Neglected Brassica Species to Improve Stress-Tolerant Crops -- 5. Improved Tolerance to Stresses of Different Origin in Camelina sativa: Conventional Breeding and Biotechnology -- 6. Brassicaceae Plants Response and Tolerance to Salinity -- 7. Brassicaceae Plants Response and Tolerance to Drought Stress: Physiological and Molecular Interventions -- 8.Rapeseed: Biology and Physiological Responses to Drought stress -- 9. Responses and Tolerance of Brassicas to High Temperature -- 10.Brassicaceae Plants Response and Tolerance to Waterlogging and Flood etc. .
    Abstract: This book provides all aspects of the physiology, stress responses and tolerance to abiotic stresses of the Brassicaceae plants. Different plant families have been providing food, fodder, fuel, medicine and other basic needs for the human and animal since the ancient time. Among the plant families, Brassicaceae has special importance for their agri-horticultural importance and multifarious uses apart from the basic needs. Interest understanding the response of Brassicaceae plants toward abiotic stresses is growing considering the economic importance and the special adaptive mechanisms. The knowledge needs to be translated into improved elite lines that can contribute to achieve food security. The physiological and molecular mechanisms acting on Brassicaceae introduced in this book are useful to students and researchers working on biology, physiology, environmental interactions and biotechnology of Brassicaceae plants.
    Type of Medium: Online Resource
    Pages: XIV, 531 p. 29 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811563454
    DDC: 571.2
    Language: English
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  • 90
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Human physiology. ; Nanotechnology. ; Biology Technique. ; Pharmacology. ; Human Physiology. ; Nanotechnology. ; Experimental Organisms. ; Pharmacology.
    Description / Table of Contents: Chapter 1. Synthesis and characterization of nanoparticles used in consumer products -- Chapter 2. Model organisms for in vivo assessment of nanoparticles -- Chapter 3. Impact of nanoparticles on behavior and physiology of Drosophila melanogaster -- Chapter 4. Dose-dependent influence of nanoparticles on fertility and survival -- Chapter 5. Effect of nanoparticles on maintenance of metabolic homeostasis -- Chapter 6. Nanoparticles: an activator of oxidative stress -- Chapter 7. Safe dose of nanoparticles: A boon for consumer goods and biomedical application.
    Abstract: This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications. Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.
    Type of Medium: Online Resource
    Pages: XII, 122 p. 34 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811555220
    DDC: 612
    Language: English
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  • 91
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Surgery. ; Cancer Treatment. ; Orthopedic surgery. ; Neurosurgery. ; Cancer Therapy. ; Surgical Orthopedics.
    Description / Table of Contents: Advanced spinal anatomy and applications for the spine tumor surgeon -- Modern Pathology in Spinal Tumors -- Tumor Classification and Staging Systems in Orthopaedic Spine Surgery -- Advanced imaging technologies in the evaluation and staging of adult spine tumors -- Modern Multidisciplinary Care in Spine Tumors -- Modern care of benign tumors of the spine -- Low Grade Spinal Malignancies: Chordoma and Chondrosarcoma -- High-grade primary spinal malignancies -- Extradural Spine Tumor Mimics -- Special anatomical zone: Sacral and spinopelvic tumors -- Special Anatomical Zone: Craniocervical Junction Tumors -- Prognosis and Decision Making in Spinal Metastases -- Economic Value in Spinal Tumor Surgery -- State of the Art for Metastatic Histologies -- Modern technical concepts in surgical metastatic disease -- Radiotherapy in metastatic spinal disease -- Percutaneous Modalities -- Lateral Corpectomy for Spinal Neoplasms -- Minimally Invasive Approaches to Thoracic and Lumbar Metastatic Spine Disease -- Complex Reconstruction in Tumor Patients -- Radiation, robotics, and reconstructive options in spine tumor surgery -- Spine Tumors: Technological Advances.
    Abstract: This book contains the expert knowledge base of the field’s most experienced practitioners in the field of extradural bone and soft tissue malignancy. Chapters include modern classification, advanced anatomy, imaging, and the concepts around a multidisciplinary approach. Since treating primary tumors requires very different strategies than those used in metastatic tumors, the book devotes separate sections to each sub-discipline. For primary tumors, the text covers both benign and malignant entities and addresses unique anatomic zones such as the sacrum and skull base which require special technical expertise. For metastatic disease, the authors address the ever-important concept of prognosis, and discuss how to answer the eternal question: “How much should we do, and for whom?”. Chapters also explore the state of the art of treatment for the “big 5” histologies (renal cell, lung, breast, prostate, thyroid), with a special chapter emphasis on separation surgery and the now-standard combinatorial care between radiation and surgery. In addition, an entire section is dedicated to evolving surgical technology, which covers the use of minimally invasive techniques, navigation, robotics, 3D-printing, and other evolving technologies for spine tumor care. Infrequently-considered topics, such as how to evaluate a lesion which may be a tumor-mimic, and how to think about economic value in spine tumor surgery, are also presented. Surgical Spinal Oncology serves to help surgeons approach difficult clinical scenarios with a thoughtful, collaborative approach that leverages the best technology and thinking the field of spine oncology has to offer.
    Type of Medium: Online Resource
    Pages: XIV, 378 p. 155 illus., 84 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030507220
    DDC: 617.48
    Language: English
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  • 92
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant biotechnology. ; Nanotechnology. ; Microbiology. ; Botanical chemistry. ; Freshwater ecology. ; Marine ecology. ; Plant Biotechnology. ; Nanotechnology. ; Microbiology. ; Plant Biochemistry. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Preface -- Introduction: Nanotechnology and Nanobiotechnology, Different Types of Nanomaterials, and General Characterization Techniques -- Microbial Synthesis of Different Nanomaterials using Prokaryotic Microorganisms (Bacteria and Actinomycetes) -- Microbial Synthesis of Different Nanomaterials using Prokaryotic Microorganisms (Bacteria and Actinomycetes) -- Photosynthesis of Different Nanomaterials Using Different Plant Extracts and the Extracts of Agro-Industrial Waste (Phytonanotechnology) -- Different Application Fields of Biologically Synthesized Nanoparticles -- Safety of Prepared Nanomaterials and Future Prospectives -- Bibliography -- Index.
    Abstract: The generation of well-defined nanoparticles of excellent size and shape involves physical and chemical methodologies that are complicated, expensive, and produce hazardous toxic waste that is harmful to the environment and to human health. In order to combat the disadvantages of these methods, scientists have created “the biological method,” a new synthetic methodology that serves as a proper alternative to physical and chemical methodologies because of its easy utility, low cost, rapid synthesis, controlled size characteristics, controlled toxicity, and eco-friendliness. Nanobiotechnology is the science in which living matter can be manipulated and exploited to produce materials within the nano-scale. It is a multidisciplinary field of science framed by biology, chemistry, engineering, materials, and life sciences. Different biological entities can be exploited to yield biologically synthesized nanomaterials including bacteria, actinomycetes, yeast, fungi, viruses, algae, plant extracts, and agro-industrial waste extracts. This book represents a comprehensive review concerning the state of the art in nanobiotechnology, emphasizing the use of diverse biological entities in the science, and its versatile applications. It describes currently existing methodology with the latest published references, and provides safety information. It serves as the ideal guide for scientists interested in exploring nanobiotechnology.
    Type of Medium: Online Resource
    Pages: XX, 230 p. 13 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030460716
    Series Statement: Nanotechnology in the Life Sciences,
    DDC: 631.52
    Language: English
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  • 93
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medicine Philosophy. ; Medical sciences. ; Science Philosophy. ; Biomedical Research. ; Philosophy of Medicine. ; Health Sciences. ; Philosophy of Science.
    Abstract: This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final part looks at more clinical or practical perspectives. It thereby gathers, across 30 chapters, diverse perspectives from the broad fields of evolutionary and systems biology, immunology, and biogerontology, more specific areas such as odontology, cardiology, neurology, and public health, as well as philosophical reflections on mental health, sexuality, authenticity and medical theories. The overarching aim is to inform, inspire and encourage intellectuals from various disciplines to assess whether explanations in these disparate fields and across biological levels can be sufficiently systematized and unified to clarify the complexity of health. It will be particularly useful for medical graduates, philosophy graduates and research professionals in the life sciences and general medicine, as well as for upper-level graduate philosophy of science students.
    Type of Medium: Online Resource
    Pages: XVII, 555 p. 30 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030526634
    Series Statement: Healthy Ageing and Longevity, 12
    DDC: 610.72
    Language: English
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  • 94
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Food science. ; Plant ecology. ; Economic geography. ; Agriculture. ; Plant Science. ; Food Science. ; Plant Ecology. ; Economic Geography. ; Agriculture.
    Description / Table of Contents: Preface -- Chapter 1 Introduction -- Chapter 2 The Pepper Plant—Its Botany and Chemistry -- Chapter 3 Pepper Agronomy -- Chapter 4 The Role of the Nutrient Buffer Power Concept in Pepper Nutrition -- Chapter 5 Establishing a Pepper Plantation -- Chapter 6 Pepper Pests and Their Control -- Chapter 7 The Processing of Black Pepper on Farm -- Chapter 8 An Account of Indonesian Pepper Processing -- Chapter 9 Industrial Processing of Black Pepper -- Chapter 10 The Future of the Global Pepper Economy -- Chapter 11 Pepper Economy in India -- Chapter 12 Pepper Pharmacopoeia -- Chapter 13 Consumer Products Out of Black Pepper -- Chapter 14 Value Addition in Pepper -- Chapter 15 Conclusions and a Peep Into Pepper’s Future -- PRECISE QUANTIFICATION OF PLANT NUTRIENT BIO AVAILABILITY FOR BLACK PEPPER AND CARDAMOM -- TECHNOLOGICAL INNOVATIONS IN SPICES RESEARCH AND DEVELOPMENT!!!.
    Abstract: This book considers all aspects of black pepper from its growth, as a flowering vine, to how the dried fruit (peppercorn) is used as a spice and traded as a commodity. It is the economic mainstay of several India states and, principally, in Kerala State, with the Indian subcontinent being the largest black pepper producer. Indonesia has also emerged as a large producer of black pepper. Black pepper commands a leading position among the spices and has an immense commercial importance to world trade, finding its way onto the dining table of millions around the world, on the European and North American continents, and Japan. The use of black pepper ranges from a simple dietary component and flavour enhancer, to that of a spice with huge pharmacological benefits. .
    Type of Medium: Online Resource
    Pages: XIV, 162 p. 24 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030528652
    DDC: 580
    Language: English
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  • 95
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Microbiology. ; Microbial ecology. ; Botany. ; Microbiology. ; Microbial Ecology. ; Plant Science.
    Description / Table of Contents: Interaction of Epiphyllic Bacteria with Plant Cuticles -- Plant Microbiome and Its Important in Stressful Agriculture -- Plant-Microbe Interactions: Applications for Plant‐Growth Promotion and In-Situ Agri-Waste Management -- Plant-Microbe-Metal Interactions: A Biochemical and Molecular Analysis for Phytoremediation -- Ecosystem Diversity as a Function of Plant and Soil-Microbe Interactions -- Plant Growth Promoting Potentials of Endophytic Fungi for the Management of Agricultural Crops and Grasses -- Biological Control of Plant Diseases: Opportunities and Limitations -- Circadian Redox Rhythms Play an Important Role in Plant-Pathogen Interaction -- Rhizospheric Microorganisms for the Remediation of Contaminants for Ecological Restoration -- The Rhizosphere Microbiome: Microbial Communities and Plant Health -- On the Possibility of Accelerating Succession by Manipulating Soil Microorganisms -- Composition and Dynamics of Microbial Communities in Fly Ash-Amended Soil -- Molecular Insight into Plant-Fungal Pathogen Interaction: Emerging Trends and Implication in Designing Climate Smart Filed Crops -- Biochemical Dynamics of Plant Microbe Interactions -- Endophytic Secondary Metabolites for Biological Control - A Latest Perspective.
    Abstract: This book provides a comprehensive overview of the current state of knowledge on plant-microbiome interactions and associations. It covers all major mechanistic approaches used to investigate microbes’ impacts on plant growth promotion, disease control and health. The industrial manufacture of nitrogen currently accounts for roughly 2% of the world’s total energy consumption. Microbial products are expected to reduce the need for costly fertilizers, as well as chemical pesticides and fungicides. While beneficial microorganisms are increasingly being used in agriculture, abiotic and biotic stresses such as heat, drought, cold, and salt can quickly kill or render them useless in the field. However, discovering new and better treatments is a lengthy process due to the considerable microbial diversity found in soils. Researchers have now proposed using biotechnological approaches to accelerate the process of microbial technology development. The fact that plant-associated microbes stimulate plant growth and development is well known, as the examples of rhizobia and mycorrhizal fungi show. The mechanisms by which these microorganisms maintain plant growth include the production of phytohormones, fixation of nitrogen, and the mobilization of phosphorus and minerals. The plant microbiome is also involved in pathogen suppression, and especially the root microbiome acts as a protective shield against soil-borne pathogens. A special feature of this book is its multidisciplinary approach, spanning from plant microbiology/biocontrol, fungal and bacterial endophytes, plant physiology, to biochemistry, proteomics and genomics. It is ideally suited for researchers and student of agri-biotechnology, soil biology and fungal biology.
    Type of Medium: Online Resource
    Pages: VI, 307 p. 31 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030503956
    DDC: 579
    Language: English
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  • 96
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Immunology. ; Life sciences. ; Pharmacology. ; Medical sciences. ; Medicine History. ; Public health. ; Immunology. ; Life Sciences. ; Pharmacology. ; Health Sciences. ; History of Medicine. ; Public Health.
    Description / Table of Contents: 1. Introduction -- 2. From Africa to England -- 3. The children's clinic at Keyworth -- 4. Whooping cough vaccine -- 5. 1977-79: The first outbreak of whooping cough -- 6. Does the vaccine work? -- 7. 1981: Whooping cough vaccine is very rarely harmful -- 8. 1981-83: The second outbreak. How many cases are there really? -- 9.1985-87: The third outbreak. The search for subclinical infection -- 10. Does the effectiveness of the vaccine wear off? -- 11. 1988: Trying to raise the uptake of pertussis vaccine -- 12. 1989-91: The fourth outbreak. The natural history of whooping cough -- 13. 1990's: Whooping cough fades away but new diagnostic tests emerge -- 14. 2000: Whoopingcough.net. Overcoming diagnostic paralysis -- 15. The early noughties: The new tests aid the rediscovery of whooping cough -- 16. Late noughties: "Resurgence" of whooping cough in the USA and Australia puts the UK on alert -- 17. 2012: Whooping cough diagnoses peak in the UK but remain unchanged in Keyworth -- 18. What lies ahead? -- 19. Epilogue -- Appendix.
    Abstract: Outbreak in the Village is a fascinating account of the personal and professional journey of Dr. Doug Jenkinson, physician and researcher. Over the course of four decades in practice, Jenkinson traces the reemergence of whooping cough in the developed world, using his practice in the idyllic English countryside as a clinical control group. Keeping meticulous notes and indulging an itch to investigate, he explores one of history's most enigmatic and pervasive diseases. Jenkinson relates the tale of his life's work amid winsome anecdotes, relevant history, and practical advice. Told in an amiable, engaging voice with an expert balance of levity and earnestness, this story will charm casual readers interested in medical history and memoir, as well as doctors and researchers who identify with the experiences and may benefit from the research and techniques employed. Readers will find themselves in the examination room beside Jenkinson as the investigation unfolds, learning about the nature of the illness and the sweeping detrimental effects of an anti-vaccination campaign. An intriguing memoir about a mysterious illness, a public health failure, and one doctor's quest for clarity, Outbreak in the Village is a tale of perseverance and objectivity sure to delight and inform. .
    Type of Medium: Online Resource
    Pages: XXIII, 158 p. 63 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030454852
    Series Statement: Springer Biographies,
    DDC: 571.96
    Language: English
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  • 97
    Keywords: Agriculture. ; Botanical chemistry. ; Plant physiology. ; Soil science. ; Plant biotechnology. ; Agriculture. ; Plant Biochemistry. ; Plant Physiology. ; Soil Science. ; Plant Biotechnology.
    Description / Table of Contents: 1. Application of nanotechnology in agricultural farm animals -- 2. Nano-particles in plant growth and development -- 3. Use of nanotechnology in quality improvement of economically important agricultural crops -- 4. Agriculture and nano particles -- 5. Large Scale Production / Biosynthesis of Biogenic Nanoparticles -- 6. Role of nanotechnology in management of agricultural pests -- 7. Biogenic Nano Materials: Synthesis and Its Applications for Sustainable Development -- 8. An Overview on Effect of Soil Physicochemical Properties on Immobilization of Biogenic Nanoparticle -- 9. Biogenic Nanoparticles as Novel Sustainable Approach for Plant Protection -- 10. Biogenic Nanoparticles in the Insect World: Challenges and Constraints -- 11. Biogenic Synthesis of Gold Nanoparticles and Their Potential Application in Agriculture -- 12. Application of Biogenic and nonbiogenic synthesized metals nanoparticles on longevity of agricultural crops -- 13. Nanoparticles and their Fate in Soil Ecosystem -- 14. Impact of nanoparticles on PGPR and soil nutrient contents -- 15. New insights into application of Nanoparticles for plant growth promotion: Present and Future prospects -- 16. Nanoparticles: Emerging Trends and Future Prospects for Economical Agricultural System -- 17. Integrated Approach of Agri-nanotechnology: Recent developments, Challenges and Future Trends -- 18. Green-nanotechnology for Precision and Sustainable Agriculture -- 19. Nanotechnology and nutrigenomics -- 20. Recent Developments In Nanocarrier Based Nutraceuticals For Therapeutic Purposes -- 21. Current status of biologically produced nanoparticles in agriculture -- 22. A Missing Dilemma on Nanoparticle Producer-Microorganisms -- 23. dedication and degradation of pesticides using nanomaterials -- 24. Use if nano materials in food science -- 25. Biogenic Nanomaterials and their Applications in Agriculture -- 26. Biosensors and Nanobiosensors in Environmental applications -- 27. Biogenenic synthesis of metals nanoparticles by plants.
    Abstract: Several nano-scale devices have emerged that are capable of analysing plant diseases, nutrient deficiencies and any other ailments that may affect food security in agro-ecosystems. It has been envisioned that smart delivery systems can be developed and utilised for better management of agricultural ecosystems. These systems could exhibit beneficial, multi-functional characteristics, which could be used to assess and also control habitat-imposed stresses to crops. Nanoparticle-mediated smart delivery systems can control the delivery of nutrients or bioactive and/or pesticide molecules in plants. It has been suggested that nano-particles in plants might help determine their nutrient status and could also be used as cures in agro-ecosystems. Further, to enhance soil and crop productivity, nanotechnology has been used to create and deliver nano fertilizers, which can be defined as nano-particles that directly help supply nutrients for plant growth and soil productivity. Nano-particles can be absorbed onto clay networks, leading to improved soil health and more efficient nutrient use by crops. Additionally, fertilizer particles can be coated with nano-particles that facilitate slow and steady release of nutrients, reducing loss of nutrients and enhancing their efficiency in agri-crops. Although the use of nanotechnology in agro-ecosystems is still in its early stages and needs to be developed further, nano-particle-mediated delivery systems are promising solutions for the successful management of agri-ecosystems. In this context, the book offers insights into nanotechnology in agro-ecosystems with reference to biogenic nanoparticles. A useful resource for postgraduate and research students in the field of plant and agricultural sciences, it is also of interest to researchers working in nano and biotechnology.
    Type of Medium: Online Resource
    Pages: XVIII, 606 p. 65 illus., 53 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811529856
    DDC: 630
    Language: English
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  • 98
    Keywords: Pharmacology. ; Human physiology. ; Nanotechnology. ; Biology Technique. ; Pharmacology. ; Human Physiology. ; Nanotechnology. ; Experimental Organisms.
    Description / Table of Contents: Chapter 1. Nanotechnology : Application in biology and medicine -- Chapter 2. Biological activities of nanoparticles and mechanism of action -- Chapter 3. Application of nanoparticles in Drug delivery -- Chapter 4. Antimicrobial activity of metallic nanoparticles using prokaryotic model organisms -- Chapter 5. Modelling nanoparticles parameters for antibacterial activities -- Chapter 6. Saccharomyces cerevisiae as model organism to study biological activities of nanoparticles -- Chapter 7. Investigation of Biological activities of Nanoparticles using Cell Lines -- Chapter 8. Caenorhabditis elegans: a model organism to decipher biological activities of nanoparticles -- Chapter 9. Zebra fish model system to investigate biological activities of nanoparticles -- Chapter 10. Drosophila melanogaster - A model organism to understand biological activities of nanoparticles -- Chapter 11. Understanding the biological activities of nanoparticles using murine models -- Chapter 12. Insecticidal activity nanoparticles and mechanism of action -- Chapter 13. Routes of Exposures and Toxicity of Nanoparticles -- Chapter 14. Toxicological evaluation of nanoparticles using prokaryotic model organisms -- Chapter 15. Evaluation of Toxicity Nanoparticles using Cell lines -- Chapter 16. Saccharomyces cerevisiae : Model organism to evaluate nanoparticles toxicity -- Chapter 17. Caenorhabditis elegans: Evaluation of nanoparticle toxicity -- Chapter 18. Zebra fish: A laboratory model to evaluate Nanoparticle Toxicity -- Chapter 19. Evaluation of toxicity of nanoparticles using Brine Shrimp -- Chapter 20. Drosophila Model to Decipher the Toxicity of Nanoparticles -- Chapter 21. Murine models to understand the toxicity of nanoparticles -- Chapter 22. Challenges and future perspectives of Nanotoxicology.
    Abstract: This book provides a comprehensive overview of state-of-the-art applications of nanotechnology in biology and medicine, as well as model organisms that can help us understand the biological activity and associated toxicity of nanoparticles, and devise strategies to minimize toxicity and enhance therapies. Thanks to their high surface-to-volume ratio, nanoparticles are characterized by excellent biocompatibility and bioavailability, a high therapeutic index, and relatively low toxicity, which has led to their widespread application in the early diagnosis of diseases, comprehensive monitoring of disease progression, and improved therapeutics. The book also explores nanoparticle-based insecticides and their mechanisms of action, and provides a comparative analysis of the various model organisms that are used to understand the biological properties of nanoparticles. Further, it describes various in-vivo models that yield important insights into nanomaterial-mediated toxicity, promoting the optimal utilization of nanoparticles. In closing, the book discusses future perspectives and regulatory issues concerning the use of nanomaterials in translational research.
    Type of Medium: Online Resource
    Pages: XIII, 466 p. 64 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811517020
    DDC: 615
    Language: English
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  • 99
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant biotechnology. ; Environment. ; Agriculture. ; Plant genetics. ; Plant Biotechnology. ; Environmental Sciences. ; Agriculture. ; Plant Genetics.
    Description / Table of Contents: Genomic Designing for New Climate-Resilient Almond Varieties -- Challenges and Strategies for Developing Climate-Smart Apple Varieties through Genomic Approaches -- Genomic Designing for New Climate-Resilient Apricot Varieties in a Warming Context -- Breeding Climate Resilient Bananas.
    Abstract: This edited book provides a comprehensive overview of modern strategies in fruit crop breeding in the era of climate change and global warming. It demonstrates how advances in plant molecular and genomics-assisted breeding can be utilized to produce improved fruit crops with climate-smart traits. Agriculture is facing a number of challenges in the 21st century, as it has to address food, nutritional, energy and environmental security. Future fruit varieties must be adaptive to the varying scenarios of climate change, produce higher yields of high-quality food, feed, and fuel and have multiple uses. To achieve these goals, it is imperative to employ modern tools of molecular breeding, genetic engineering and genomics for ‘precise’ plant breeding to produce ‘designed’ fruit crop varieties. This book is of interest to scientists working in the fields of plant genetics, genomics, breeding, biotechnology, and in the disciplines of agronomy and horticulture.
    Type of Medium: Online Resource
    Pages: XX, 404 p. 27 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783319979465
    DDC: 631.52
    Language: English
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  • 100
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Evolution (Biology). ; Biodiversity. ; Plants Evolution. ; Biotic communities. ; Population biology. ; Animal migration. ; Evolutionary Theory. ; Biodiversity. ; Evolutionary Biology. ; Plant Evolution. ; Community and Population Ecology. ; Animal Migration.
    Description / Table of Contents: Chapter 1. Introduction -- Part 1. Neotropical diversity and diversification -- Chapter 2. Neotropical diversification: historical overview and conceptual insights -- Chapter 3. Beyond refugia: New insights on Quaternary climate variation and the evolution of biotic diversity in tropical South America -- Chapter 4. Tropical and subtropical in South America: a study of community turnover across environmental gradients -- Chapter 5. Evolutionary macroecology and the geographical patterns of Neotropical diversification -- Chapter 6. Evolutionary imprints on species distribution patterns across the Neotropics -- Chapter 7. Avian diversity in humid tropical and subtropical south American forests, with a discussion about their related climatic and geological underpinnings -- Chapter 8. Contrasting patterns of temporal diversification in Neotropical butterflies: An overview -- Chapter 9. Diatom diversity and biogeography across tropical South America -- Part 2. Regional biodiversity patterns and diversification processes -- Chapter 10. The origin and evolution of Amazonian species diversity -- Chapter 11. Patterns and processes of diversification in Amazonian white sand ecosystems: insights from birds and plants -- Chapter 12. Human contribution to Amazonian plant diversity: legacy of pre-Columbian land use in modern plant communities -- Chapter 13. On the young savannas in the land of ancient forests -- Chapter 14. The diversification of extant Angiosperms in the South America dry diagonal -- Chapter 15. Diversity, endemism, and evolutionary history of montane biotas outside the Andean region -- Chapter 16. Patterns of species and lineage diversity in the Atlantic rainforest of Brazil -- Chapter 17. Diversification in ancient and nutrient-poor Neotropical ecosystems: how geological and climatic buffering have shaped plant diversity in some of the world’s neglected hotspots -- Chapter 18. Bioregions of Eastern Brazil, based on vascular plant occurrence data -- Chapter 19. Forests diversity in the Mexican neotropics: A paleocological view -- Chapter 20. Historical biogeography of Caribbean plants revises regional paleogeography -- Part 3. Taxon-based local and regional studies -- Chapter 21. Amphibians and reptiles of Venezuelan Guayana: diversity, biogeography and conservation -- Chapter 22. Origin of elevational replacements in a clade of nearly flightless birds – most diversity in tropical mountains accumulates via secondary contact following allopatric speciation -- Chapter 23. Clade-specific biogeographic history and climatic niche shifts of the southern Andean-southern Brazilian disjunction in plants -- Chapter 24. Biotic and landscape evolution in an Amazonian contact zone: insights from the herpetofauna of the Tapajós River basin -- Chapter 25. Diversification processes in lizards and snakes from the middle São Francisco River dune region -- Chapter 26. Unexpected beta-diversity radiations in highland clades of Andean Terraranae frogs -- Chapter 27. Disparate patterns of diversification within Liolaemini lizards -- Chapter 28. Diversification history of Neotropical Lecythidaceae, an ecologically dominant tree family of Amazon rain forest -- Part 4. IV. Epilogue -- Chapter 29. Conservation in the Neotropics – a final reflection. .
    Abstract: This book provides a comprehensive overview of the patterns of biodiversity in various neotropical ecosystems, as well as a discussion on their historical biogeographies and underlying diversification processes. All chapters were written by prominent researchers in the fields of tropical biology, molecular ecology, climatology, paleoecology, and geography, producing an outstanding collection of essays, synthetic analyses, and novel investigations that describe and improve our understanding of the biodiversity of this unique region. With chapters on the Amazon and Caribbean forests, the Atlantic rainforests, the Andes, the Cerrado savannahs, the Caatinga drylands, the Chaco, and Mesoamerica – along with broad taxonomic coverage – this book summarizes a wide range of hypotheses, views, and methods concerning the processes and mechanisms of neotropical diversification. The range of perspectives presented makes the book a truly comprehensive, state-of-the-art publication on the topic, which will fascinate both scientists and general readers alike.
    Type of Medium: Online Resource
    Pages: X, 820 p. 150 illus., 126 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030311674
    Series Statement: Fascinating Life Sciences,
    DDC: 576.801
    Language: English
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