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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Reproduction. ; Physiology. ; Anatomy. ; Cytology. ; Human Physiology. ; Reproductive Physiology. ; Anatomy. ; Cell Biology.
    Description / Table of Contents: Chapter 1: Introduction -- Chapter 2: Origin and development of the breast -- Chapter 3: Structure of the lactating breast -- Chapter 4: Breast function during the initial period of lactation (lactogenesis I and II) -- Chapter 5: The period of established lactation (lactogenesis III).
    Abstract: This comprehensive Monograph examines all peripheral and central mechanisms of regulating the secretion of milk from the lactating breast. The author reviews the complete female breast development, starting with the early childhood, up to pregnancy and lactation. Structural and ultrastructural data on the alveolar-ductal system, together with details of breast innervation, are used to investigate the physiological process of lactation. Readers will appreciate the special focus on reflexes, both in the child and the mother, that help to regulate maternal milk production and secretion. Following this, the author sheds a light on the composition and dynamics of milk components during the different periods of lactation. The final section of this volume focusses on practical aspects of modern breastfeeding, like the use of breast pumps or galactogogues, to influence the productivity of milk production. These fundamental principles and structural details will be particularly useful for physiologists and clinicians working in gynecology and pediatrics.
    Type of Medium: Online Resource
    Pages: VIII, 254 p. 87 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030663643
    DDC: 612
    Language: English
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  • 2
    Keywords: Pharmacology. ; Cardiology. ; Neurosciences. ; Clinical biochemistry. ; Pharmacology. ; Cardiology. ; Neuroscience. ; Medical Biochemistry.
    Description / Table of Contents: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.
    Abstract: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 425 p. 70 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030685102
    Series Statement: Handbook of Experimental Pharmacology, 264
    DDC: 615
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Proteins . ; Biotechnology. ; Enzymology. ; Bioorganic chemistry. ; Protein Biochemistry. ; Chemical Bioengineering. ; Enzymology. ; Bioorganic Chemistry.
    Description / Table of Contents: Preface -- Chapter 1: Introduction -- Chapter 2: Enzyme Cascade Design – Retrosynthesis Approach -- Chapter 3 : Multi-Enzymatic Cascades in vitro -- Chapter 4: Multi-Enzymatic Cascades in vivo -- Chapter 5: Chemo-Enzymatic Cascades -- Chapter 6: Enzyme Cascade Kinetic Modelling -- Chapter 7: Enzyme Cascade Reaction Engineering -- Chapter 8: Enzyme Cascade Process Design and Modelling -- Chapter 9: Enzyme Cascade Reaction Monitoring And Control -- Chapter 10: Cascade reactions in non-conventional media -- Chapter 11: Perspectives.
    Abstract: This book provides a comprehensive overview of the recent developments achieved in the field of chemo/enzymatic cascades with topics spanning from design (in vitro and in vivo) to kinetic- and process modelling as well as process control. Opportunities and challenges of building multi-step chemo/enzymatic reactions are discussed, whereby the latter are critically assessed in each chapter and methods to ease the implementation are explored. Both, multi-enzymatic cascades and chemo-enzymatic cascades are presented with the motivation of combining the strengths of these two worlds (e.g. selectivity, activity and robustness) not neglecting the obstacles and challenges of such endeavour. Furthermore, the use of non-conventional media for catalytic cascade reactions, recent achievements and potential for future developments in a technical environment are addressed.
    Type of Medium: Online Resource
    Pages: VII, 181 p. 103 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030657185
    DDC: 572.6
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Radiology. ; Spectrum analysis. ; Pharmaceutical chemistry. ; Nutrition   . ; Biomedical Research. ; Radiology. ; Spectroscopy. ; Pharmaceutics. ; Nutrition.
    Description / Table of Contents: Ch 1: Electron Spin Resonance- An Introdcution -- Ch 2: ESR – Applications in Healthcare and Pharmaceutical Science -- Ch 3: ESR Applications in Paleontology and Geochronology -- Ch 4: ESR Applications in Food Science.
    Abstract: This book introduces the audience with basic theoretical and experimental aspects of Electron Spin Resonance (ESR) Spectroscopy. It further talks about ESR spectroscopy applications in Healthcare & Pharmaceutical Science, Paleontology & Geochronology and Food Science. Mathematical details have been kept to a necessary minimum and emphasis is given to highlight the applications of the technique.
    Type of Medium: Online Resource
    Pages: X, 72 p. 32 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030641986
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    DDC: 610.72
    Language: English
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  • 5
    Keywords: Pharmacology. ; Medical genetics. ; Pathology. ; Pharmacology. ; Clinical Genetics. ; Pathology.
    Description / Table of Contents: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.
    Abstract: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
    Type of Medium: Online Resource
    Pages: VIII, 323 p. 70 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030700638
    Series Statement: Handbook of Experimental Pharmacology, 265
    DDC: 615
    Language: English
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  • 6
    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Biodiversity. ; Animal migration. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Biodiversity. ; Animal Migration.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. European pearl mussel: background information and literature review -- Chapter 3. Materials and methods -- Chapter 4. Results -- Chapter 5. Discussion -- Chapter 6. Conclusions.
    Abstract: The monograph focuses on the European freshwater pearl mussel Margaritifera margaritifera, which is an endangered bivalve species. Most of its populations in the Russian section of the Baltic Sea basin had never been studied, although they were known in the past to the pearl fishers. “Rediscovery” included search for the previously unknown populations, revealing the facts of population extinctions, analysis of negative impacts, elaboration of conservation measures, and revealing of regularities in distribution. Patterns of land use and river management were analyzed. The procedure of “rediscovery” was applied for other animal species of Northwest Russia, which are threatened on a global scale – thick-shelled mussel, Unio crassus; curlew Numenius arquata; black-tailed godwit, Limosa limosa; Northern Lapwing, Vanellus vanellus; European mink, Mustela lutreola; pond bat, Myotis dasycneme; Atlantic sturgeon, Acipenser sturio; and broad-clawed crayfish, Astacus astacus. The methods and principles of conservation studies were discussed. The obtained data were analyzed with respect to current global change of biosphere. The book will appeal to specialists dealing with conservation studies and activities such as red lists, river protection, and conservation of endangered species. Moreover, a part of the book represents an interest for biogerontology as it presents discredit of the popular concept on “negligible senescence.” The data on distribution of some animals in Russia will be interesting in terms of zoology and biogeography, as they are not yet sufficiently represented in the international editions. The book can be used as supplemental reading for courses in biological invasions, ecology and conservation, and biodiversity. The work also contains chapters on global processes (deforestation, desertification, river degradation) and can therefore also be used for general courses in environmental sciences.
    Type of Medium: Online Resource
    Pages: XI, 246 p. 88 illus., 87 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030662554
    DDC: 577.6
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant biotechnology. ; Plant genetics. ; Agriculture. ; Plant Biotechnology. ; Plant Genetics. ; Agriculture.
    Description / Table of Contents: Economic/Academic importance -- Background of the sequencing initiatives -- Molecular mapping and cloning of genes and QTLs -- Physical mapping of the genome -- Whole genome sequencing and assembling -- Structure and composition of centromere in Brassica genome -- Genome annotation -- Gene loss -- Alternative splicing -- Gene conversion -- Gene family differentiation in Brassica species -- Glucosinates -- R genes variations after triplication -- Structural & functional genomic resources developed -- Impact on plant breeding and crop improvement -- Data bases -- Future prospects.
    Abstract: This book presents comprehensive information on genetics, genomics and breeding in Brassica oleracea, an agriculturally important species that includes popular vegetable crops such as cabbage, cauliflower, broccoli, Brussels sprouts, kale, collard greens, savoy, kohlrabi, and gai lan. The content spans whole genome sequencing, assembly and gene annotation for this global vegetable species, along with molecular mapping and cloning of genes, physical genome mapping and analyses of the structure and composition of centromeres in the B. oleracea genome. The book also elaborates on asymmetrical genome evolution and transposable elements in the B. oleracea describes gene family differentiation in comparison to other Brassica species and structural and functional genomic resources and data bases developed for B. oleracea. Useful discussions on the impact of genome sequencing on genetic improvement in the species are also included.
    Type of Medium: Online Resource
    Pages: XXIV, 145 p. 33 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030310059
    Series Statement: Compendium of Plant Genomes,
    DDC: 631.52
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Internal medicine. ; Hematology. ; Biomedical Research. ; Cell Biology. ; Internal Medicine. ; Hematology.
    Description / Table of Contents: Live Donors of Tissue -- Deceased Tissue Donors -- Banking and Use of Umbilical Cord Blood -- Ocular tissue banking -- Banking of Heart Valves -- Cryopreservation and Banking of Haematopoietic Progenitor Cells -- Storage, Processing and Preservation -- Cryopreservation in tissue banking -- Sterilisation by Irradiation -- Screening the tissue donor for infectious agents -- Contamination in the Tissue Way -- Establishing a Quality System in a Tissue Establishment -- IT System requirements for Tissue and Cell Banking -- Ethical and Regulatory Aspects of Cell and Tissue Banking -- Human embryonic stem cell banking for clinical applications – 20 years from their isolation.
    Abstract: It has been 10 years since the first edition of ‘Essentials of Tissue Banking’ has been published. There is still relatively little published on the technical and scientific principles on routine tissue and cell banking based on scientific principles. The 1st edition was very successful and, after a 10 year gap, there is a need of an update and an expansion of the book’s remit. The format of the book follows that of the previous edition- split into 5 sections. Management of donors and the banking of common tissues and cells; Principles of storage and processing of tissues and cells; Ensuring the safety of the products by testing the donor, the tissues and the environment, supported by a quality system and an IT infrastructure- all working within the constraints of current regulatory and ethical environments. This edition however provides a significant update. Many the chapters have been completely rewritten by different experts. Like the 1st edition, they were given a free hand in the way they wrote their chapter, with a guideline that they had to be concise, clear and up to date. The authors were also asked to provide the scientific and technical basis that provides the rationale of the processes they describe. Also, the scope of the book has been somewhat extended. In view of the fact that many cellular therapies are now routinely practiced, 2 new chapters have been added: one on the banking of haematopoietic stem cells and one on human embryonic stem cells. They have been deliberately chosen to illustrate the extreme spectrum of cellular therapies from one of the simplest to one of the most complex. The intention of the book has remained the same: to cover and update banking of current practices in essential tissue and cell banking. It is therefore hoped that by keeping the book as concise and up to date as possible, it will find a place on the shelves of many tissue establishments.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 48 illus., 28 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030716219
    DDC: 610.72
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical microbiology. ; Pharmacology. ; Pediatrics. ; Medical Microbiology. ; Pharmacology. ; Pediatrics.
    Description / Table of Contents: Part 1 General Vaccinology -- 1 Expected and Unexpected Effects of Vaccination -- 2 How Vaccinating People Can Also Protect Others -- 3 Childhood and Adolescent Immunization Programs in Europe -- 4 Vaccine Hesitancy, Acceptance, and Demand -- 5 Adjuvants in Pediatric Vaccines -- 6 Maternal Immunization -- 7 Neonatal Immunization -- Part 2 Viral Vaccines and Vaccinations -- 8 Poliovirus Vaccines -- 9 Measles–Mumps–Rubella Vaccine -- 10 Varicella Vaccines -- 11 Rotavirus Vaccine -- 12 Hepatitis A Vaccines -- 13 Hepatitis B Vaccines -- 14 Influenza Vaccines -- 15 Human Papillomavirus Vaccines -- 16 Tick-Borne Encephalitis Vaccines -- Part 3 Bacterial Vaccines and Vaccination -- 17 Tuberculosis Vaccines -- 18 Pertussis Vaccines -- 19 Haemophilus influenzae type b (Hib) Vaccines -- 20 Pediatric Combination Vaccines -- 21 Pneumococcal Vaccines -- 22 Meningococcal Vaccines -- 23 Pediatric Vaccines for Travel Outside Europe -- Part 4 New Vaccines in Pipeline Development -- 24 GBS and CMV Vaccines in Pipeline Development -- 25 Norovirus Vaccines in Pipeline Development -- 26 RSV Vaccines and Monoclonal Antibodies in Development -- 27 COVID-19 in Children and COVID-19 Vaccines -- 28 Registration of Vaccines, Safety Follow-Up, and Pediatric Investigation Plan.
    Abstract: This second fully updated and extended edition of the textbook serves as a highly readable guide on latest developments in vaccine development and vaccination programs in infants, children and adolescents from a European perspective. The first part of the book introduces to general vaccinology, immunization programs and formulation, effects and unwanted effects of vaccines. The second and third part provide an overview on current viral and bacterial vaccines. The fourth and last part of this book discusses new vaccines in the pipeline and gives insights into safety and regulatory matters. This second edition is extended by a whole new chapter on COVID-19 vaccines. This book serves as a reference textbook in the field and helps to standardize the information on vaccines and immunization programs in the WHO European Region.
    Type of Medium: Online Resource
    Pages: XIII, 319 p. 66 illus., 63 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030771737
    DDC: 616.9041
    Language: English
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  • 10
    Keywords: Agriculture. ; Botany. ; Agriculture. ; Plant Science.
    Description / Table of Contents: Preface -- Part I: Leaves -- Chapter 1. Advances in Chicory (Cichorium intybus L.) Breeding Strategies (Laila Aldahak, Khaled F. M. Salem, Salih H. F. Al-Salim, and Jameel M. Al-Khayri) -- Chapter 2. Chinese Cabbage (Brassica rapa L. var. pekinensis) Breeding: Application of Molecular Technology (Takumi Okamoto, Xiaochun Wei, Hasan Mehraj, Mohammad Rashed Hossain, Ayasha Akter, Naomi Miyaji, Yoshinobu Takada, Jong-In Park, Ryo Fujimoto, Ill-Sup Nou, and Masao Watanabe) -- Chapter 3. Breeding Advances and Prospects in Rocket Salad (Eruca vesicaria ssp. sativa Mill.) Cultivation (Pasquale Tripodi, Paula Santos Coelho, and Carla Guijarro-Real) -- Chapter 4. Spring Onion (Allium fistulosum L.) Breeding Strategies (Fatimah Kayat, Ahmed Mahmood Ibrahim, and Arifullah Mohammed) -- Chapter 5. Water Spinach (Ipomoea aquatica Forsk.) Breeding (Moumita Gangopadhyay, Anup Kumar Das, Subhendu Bandyopadyay, and Samanwita Das) -- Chapter 6. Watercress (Nasturtium officinale R. Br.) Breeding (Mohammadreza Hassandokht, Sajad Jafari, and Raheleh Ebrahimi) -- Part II: Flowerheads and Green Pods -- Chapter 7. Advances in Cauliflower (Brassica oleracea var. botrytis L.) Breeding, with Emphasis on India (Pritam Kalia and Shrawan Singh) -- Chapter 8. Globe Artichoke (Cynara cardunculus var. scolymus L.) Breeding (Fernando López-Anido and Eugenia Martin) -- Chapter 9. Breeding Strategies of Garden Pea (Pisum sativum L.) (Amal M.E. Abdel Hamid and Khaled F.M. Salem) -- Chapter 10. Genetic Improvement of Yardlong Bean (Vigna unguiculata (L.) Walp. ssp. sesquipedalis (L.) Verdc.) (Pidigam Saidaiah, Thuraga Vishnukiran, Someswar Rao Pandravada, Natarajan Sivaraj, Adimulam Srivani, Amarapalli Geetha, Nimmarajula Srinivas, and Venkateswaran Kamala) -- Part III: Mushrooms -- Chapter 11. Enoki Mushroom (Flammulina velutipes (Curtis) Singer) Breeding (Ved P. Sharma, Anupam Barh, Rakesh Kumar Bairwa, Sudheer K. Annepu, Babita Kumari and Shwet Kamal) -- Chapter 12. Shiitake Mushroom (Lentinula edodes (Berk.) Sing.) Breeding in China (Quanju Xiang, Bilal Adil, Qiang Chen, Yunfu Gu, Xianfu Zeng, and Xinzhu Li) -- Part IV: Truffles -- Chapter 13. Desert Truffles (Terfezia spp.) Breeding (Asunción Morte, Francisco Arenas, José E. Marqués-Gálvez, Alberto Andrino, Ángel L. Guarnizo, Almudena Gutiérrez, Luis Miguel Berná, Manuela Pérez-Gilabert, Antonio Rodríguez, and Alfonso Navarro-Ródenas) -- Chapter 14. Enhancing White Truffle (Tuber magnatum Picco and T. borchii Vittad.) Cultivation through Biotechnology Innovation (Alessandra Zambonelli, Mirco Iotti, Federico Puliga, and Ian R. Hall).
    Abstract: Plant breeders and geneticists are under constant pressure to sustain and expand food production by using innovative breeding strategies and introducing minor crops, which are well adapted to marginal lands, provide a source of nutrition, and have abiotic and biotic stress tolerance, to feed an ever-increasing human population. The basic concept of this book is to examine the use of innovative methods, augmenting traditional plant breeding, towards the improvement and development of new crop varieties, under the increasingly limiting environmental and cultivation factors, to achieve sustainable agricultural production and enhanced food security. Three volumes of the book series Advances in Plant Breeding Strategies were published in 2015, 2016 and 2018, respectively: Volume 1. Breeding, Biotechnology and Molecular Tools; Volume 2. Agronomic, Abiotic and Biotic Stress Traits and Volume 3. Fruits. In 2019, the following four volumes were published: Volume 4. Nut and Beverage Crops, Volume 5. Cereals, Volume 6. Industrial and Food Crops and Volume 7. Legumes. Recent volumes published in 2021 include: Volume 8. Vegetable Crops: Bulbs, Roots and Tubers, Volume 9. Vegetable Crops: Fruits and Young Shoots and Volume 10. Vegetable Crops: Leaves, Flowerheads, Green Pods, Mushrooms and Truffles. This Volume 10, subtitled Vegetable Crops: Leaves, Flowerheads, Green Pods, Mushrooms and Truffles, consists of 14 chapters focusing on advances in breeding strategies using both traditional and modern approaches for the improvement of individual vegetable crops. Chapters are arranged in 4 parts according to the edible vegetable parts. Part I: Leaves - Chicory, Chinese cabbage, Rocket salad, Spring onion, Water spinach and Watercress; Pat II: Flowerheads and Green Pods - Cauliflower, Globe artichoke, Garden pea and Yardlong bean; Part III: Mushrooms - Enoki mushroom and Shiitake mushroom; Part IV: Truffles - Desert truffles and White truffle. Each chapter comprehensively reviews the contemporary literature on the subject and reflects the experiences of the authors. Chapters are written by internationally-reputable scientists and subjected to a review process to assure quality presentation and scientific accuracy. Each chapter begins with an introduction covering related backgrounds and provides in-depth discussion of the subject supported with high-quality color photos, illustrations and relevant data. The chapter concludes with recommendations for future research directions, a comprehensive list of pertinent references to facilitate further reading, and appendixes of genetic resources and concerned research institutes. This book series is a valuable resource for advanced students, researchers, scientists, commercial producers and seed companies as well as consultants and policymakers interested in agriculture, particularly in modern breeding technologies.
    Type of Medium: Online Resource
    Pages: XVII, 540 p. 98 illus., 76 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030669690
    DDC: 630
    Language: English
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