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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical microbiology. ; Pharmacology. ; Pediatrics. ; Medical Microbiology. ; Pharmacology. ; Pediatrics.
    Description / Table of Contents: Part 1 General Vaccinology -- 1 Expected and Unexpected Effects of Vaccination -- 2 How Vaccinating People Can Also Protect Others -- 3 Childhood and Adolescent Immunization Programs in Europe -- 4 Vaccine Hesitancy, Acceptance, and Demand -- 5 Adjuvants in Pediatric Vaccines -- 6 Maternal Immunization -- 7 Neonatal Immunization -- Part 2 Viral Vaccines and Vaccinations -- 8 Poliovirus Vaccines -- 9 Measles–Mumps–Rubella Vaccine -- 10 Varicella Vaccines -- 11 Rotavirus Vaccine -- 12 Hepatitis A Vaccines -- 13 Hepatitis B Vaccines -- 14 Influenza Vaccines -- 15 Human Papillomavirus Vaccines -- 16 Tick-Borne Encephalitis Vaccines -- Part 3 Bacterial Vaccines and Vaccination -- 17 Tuberculosis Vaccines -- 18 Pertussis Vaccines -- 19 Haemophilus influenzae type b (Hib) Vaccines -- 20 Pediatric Combination Vaccines -- 21 Pneumococcal Vaccines -- 22 Meningococcal Vaccines -- 23 Pediatric Vaccines for Travel Outside Europe -- Part 4 New Vaccines in Pipeline Development -- 24 GBS and CMV Vaccines in Pipeline Development -- 25 Norovirus Vaccines in Pipeline Development -- 26 RSV Vaccines and Monoclonal Antibodies in Development -- 27 COVID-19 in Children and COVID-19 Vaccines -- 28 Registration of Vaccines, Safety Follow-Up, and Pediatric Investigation Plan.
    Abstract: This second fully updated and extended edition of the textbook serves as a highly readable guide on latest developments in vaccine development and vaccination programs in infants, children and adolescents from a European perspective. The first part of the book introduces to general vaccinology, immunization programs and formulation, effects and unwanted effects of vaccines. The second and third part provide an overview on current viral and bacterial vaccines. The fourth and last part of this book discusses new vaccines in the pipeline and gives insights into safety and regulatory matters. This second edition is extended by a whole new chapter on COVID-19 vaccines. This book serves as a reference textbook in the field and helps to standardize the information on vaccines and immunization programs in the WHO European Region.
    Type of Medium: Online Resource
    Pages: XIII, 319 p. 66 illus., 63 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030771737
    DDC: 616.9041
    Language: English
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  • 2
    Keywords: Urban ecology (Biology). ; Environment. ; Sustainable architecture. ; Urban Ecology. ; Environmental Sciences. ; Sustainable Architecture/Green Buildings.
    Description / Table of Contents: Part I: Processes, Methods And Tools For Regenerative Design -- Foreword: Regenerative Design In Practice: Digital Design Tools To Enhance The Well-Being Of The Inhabitants Of The Natural And Built Environment (Emanuele Naboni And Lisanne Havinga) -- Chapter 1. Axiomatic Design In Regenerative Urban Climate Adaptation (Clarice Bleil De Souza And Ilya Vladimirovich Dunichkin) -- Chapter 2. Restorative Design Tools For The Existing City: H-Bim Potentials (Carlo Bianchini, Martina Attenni And Giorgia Potestà) -- Chapter 3. The Application Of Urban Building Energy Modeling In Urban Planning (Shimeng Hao And Tianzhen Hong) -- Chapter 4. Adaptation To Climate Change As A Key Dimension Of Urban Regeneration In Europe: The Cases Of Copenhagen, Vienna And Madrid (Sonia De Gregorio Hurtado) -- Chapter 5. Water Runoff And Catchment Improvement By Nature Based Solution (Nbs) Promotion In Private Household Gardens: An Agent-Based Model (Rembrandt Koppelaar, Antonino Marvuglia And Benedetto Rugani) -- Chapter 6. Carbon Accounting For Regenerative Cities (Jukka Heinonen And Juudit Ottelin) -- Chapter 7. How Rating Systems Support Regenerative Change In The Built Environment (Melinda Orova And András Reith) -- Part Ii: Innovative Approaches In Professional Design Practice -- Foreword: Bridging The Gap Between Design And Construction Following A Life Cycle Approach Consisting Of Practical Approaches For Procurement, Construction, Use & Operation And Future Life (Giulia Peretti And Carsten Druhmann) -- Chapter 8. Covering The Gap For An Effective Energy And Environmental Design Of Green Roofs: Contributions From Experimental And Modelling Researches (Laura Cirrincione And Giorgia Peri) -- Chapter 9. Gender Matters! Thermal Comfort And Individual Perception Of Indoor Environmental Quality: A Literature Review (Edeltraud Haselsteiner) -- Chapter 10. Climatic, Cultural, Behavioural And Technical Influences On The Indoor Environment Quality And Their Relevance For A Regenerative Future (Edeltraud Haselsteiner, Marielle Ferreira Silva And Željka Kordej-De Villa) -- Chapter 11. Textile As Material In Human Built Environment Interaction (Preben Hansen, Vesna Gryjoska And Milica Jovanoska) -- Chapter 12. Restorative Design For Heritage Requalification: Selected Roman Works (Luciano Cupelloni) -- Chapter 13. 3d Printing Technology Within A Regenerative Construction Framework (Odysseas Kontovourkis) -- Chapter 14. From Resilient And Regenerative Materials To A Resilient And Regenerative Built Environment (Ferhat Bejtullahu And Naomi Morishita-Steffen) -- Part Iii: Rethinking Technology Towards A Regenerative Economy -- Foreword: Rethinking Technology: Low Impact Technology For Regenerative Indoor Environment (Wilmer Pasut And Roberto Lollini) -- Chapter 15. The Blue Growth Smart Specialisation Challenges Towards The Restorative Economy (Milen Baltov) -- Chapter 16. From Restorative Building To Regenerative Economy: A Model-Theoretical Analysis On Biobased Plastics For The Construction Industry (Daniel Friedrich) -- Chapter 17. Тhe Use Of Waste Sludge: Benefits To The Regenerative Economy In Bulgaria (Angel Sarov) -- Chapter 18. Circular Economy In Construction From Waste To Green Recycled Products In Israel: A Case Study (Zvi Weinstein) -- Chapter 19. Cultural Heritage, Tourism And The Un Sustainable Development Goals: The Case Of Croatia (Željka Kordej-De Villa And Ivan Šulc) -- Chapter 20. The Green Building Approach: Recent Initiatives In The Evolving Italian Scenario (Fabrizio Tucci) -- Chapter 21. Strategies To Promote Deep Renovation In Existing Buildings (Cristina Jiménez-Pulido, Ana Jiménez-Rivero And Justo García-Navarro) -- Chapter 22. Investigating, Implementing And Funding Regenerative Urban Design In A Post-Covid-19 Pandemic Built Environment: A Reading Through The Un Sustainable Development Goals And The Green New Deal (Maria Beatrice Andreucci And Antonino Marvuglia).
    Abstract: This open access book is based on work from the COST Action “RESTORE - REthinking Sustainability TOwards a Regenerative Economy'', and highlights how sustainability in buildings, facilities and urban governance is crucial for a future that is socially just, ecologically restorative, and economically viable, for Europe and the whole planet. In light of the search for fair solutions to the climate crisis, the authors outline the urgency for the built environment sector to implement adaptation and mitigation strategies, as well as a just transition. As shown in the chapters, this can be done by applying a broader framework that enriches places, people, ecology, culture, and climate, at the core of the design task - with a particular emphasis on the benefits towards health and resilient business practices. This book is one step on the way to a paradigm shift towards restorative sustainability for new and existing buildings. The authors want to promote forward thinking and multidisciplinary knowledge, leading to solutions that celebrate the richness of design creativity. In this vision, cities of the future will enhance users’ experience, health and wellbeing inside and outside of buildings, while reconciling anthropic ecosystems and nature. A valuable resource for scientists and students in environmental sciences and architecture, as well as policy makers, practitioners and investors in urban and regional development.
    Type of Medium: Online Resource
    Pages: XXXV, 418 p. 73 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030718190
    Series Statement: Future City, 15
    DDC: 577.56
    Language: English
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  • 3
    Keywords: Geomorphology. ; Earth sciences. ; Geomorphology. ; Earth Sciences.
    Abstract: This book presents selected research highlights from the Seventh Argentine Geomorphology and Quaternary Studies Congress, hosted at Puerto Madryn, Northern Patagonia, Argentina by the Argentine Association of Geomorphology and Quaternary Studies (AACYG). The congress included special sessions, symposia, invited lectures and posters on the following topics: Quaternary stratigraphy and geochronology, paleontology (diatoms, mollusks, foraminifera, palynology, phytoliths, paleobotany, vertebrates), dendrochronology, climate change, paleoclimate, Pampean Quaternary paleolimnology, paleomagnetism, environmental magnetism, hydrogeochemical processes, geoarchaeology, geomorphology, structural geology and neotectonics, paleosurfaces, volcanism, geological hazards, assets, geomorphosites, and digital mapping. The Scientific Committee of the Congress has selected the papers published in this volume from more than 150 contributions in many different disciplines.
    Type of Medium: Online Resource
    Pages: XV, 482 p. 219 illus., 203 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030661618
    Series Statement: Springer Earth System Sciences,
    DDC: 551.41
    Language: English
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  • 4
    Keywords: Life sciences. ; Education. ; Engineering. ; Social sciences. ; Humanities. ; Science. ; Mathematics. ; Life Sciences. ; Education. ; Technology and Engineering. ; Humanities and Social Sciences. ; Physical Sciences. ; Mathematics and Computing.
    Description / Table of Contents: Foreword (Hubert Hasenauer) -- Preface -- Chapter 1. Empowering researchers: Academic mentoring -- Chapter 2. The shape of science -- Chapter 3. Doctoral studies and all that -- Chapter 4. Early career years -- Chapter 5. Scientific storytelling -- Chapter 6. Scientific presentations -- Chapter 7. Research-driven teaching -- Chapter 8. Research cooperation and job applications -- Chapter 9. Behaviour and disappointments -- Chapter 10. Sustainable data management.
    Abstract: The pace of change in academia is ever increasing, which makes it difficult for anyone to stay up to date with what may be the right long-term strategy, or even the next step in mastering a PhD or to secure a fruitful academic career. Academic mentoring has proved to be helpful to many young researchers in difficult situations and mentoring programmes have been launched at many universities. In its most basic meaning, mentoring is a goal-oriented off-line conversation between a more experienced (mentor) and a less experienced (mentee) person with the objective to empower the mentee to make important work-related decisions. The first chapter of the book offers an introduction to academic mentoring and provides an overview of what academic mentoring entails. In the following chapters, important topics are discussed that may come up in mentoring conversations. These include scientific thinking, doctoral studies, behaviour and disappointments, scientific storytelling, teaching, scientific presentations, early career years, research cooperation, job applications and basic data management. The discussions in each of these chapters were designed with a view to provide food for thought and to invite self-reflection as well as continued discussions with peers and mentors. The book is written in a highly accessible style whilst restricting each chapter to the most essential information so that reading them can be accommodated in any busy schedule. It is not limited to any particular university or geographic region, since the author has worked in a number of different countries and encountered many different academic cultures. The text is also a useful handbook and reference to go with mentoring programmes.
    Type of Medium: Online Resource
    Pages: XIV, 145 p. 6 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030654672
    DDC: 570
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Applied ecology. ; Landscape ecology. ; Biodiversity. ; Ecology . ; Freshwater ecology. ; Marine ecology. ; Applied Ecology. ; Landscape Ecology. ; Biodiversity. ; Terrestial Ecology. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Chapter 1. An introduction to Ecoacoustics -- Chapter 2. The Acoustic Complexity Indices (ACIs) -- Chapter 3. Introduction to the SonoScape, an open-source software application in MatLab® -- Chapter 4 - Exercises -- Index.
    Abstract: This book represents an introduction to ecoacoustics theory, to the application of the Acoustic Complexity Indices (ACIs) to acoustic survey, and to the use of an innovative software to process acoustic data. It enables readers to comprehend the main principles that guide the recent development of ecoacoustics and offers a synthesis about the role of sound in the ecological research. Readers will be introduced to the use of the ACIs by a detailed description of the main algorithms recently formulated and on their correct application in the acoustic processing concurring to the creation of sonic information systems. Readers will also find a new dedicated software application, namely SonoScape, that is described in detail with its codes attached in the supplementary material in a completely visible format. The SonoScape is a performing software application operating in MatLab® and is enriched of several options to manage single and large collection of acoustics files. It vides the feasibility to process data at different temporal scale, using different combination of parameters, and to extract novel complexity measures such as entropy and fractal dimension of ecoacoustic events. It also offers functions to visualize the results using customized 3-D plots or ternary plots, intuitively demonstrating the patterns of ACIs based on the vast number of numerical results. Finally, this book provides several examples of case studies with the aim of better understanding the potentiality of ACIs and the power of SonoScape as multitasking software to approaching the complexity of the ecoacoustic investigation. Students and scholars in ecology, land managers and technicians may find an important tool to interpret the complex relationship between humans and natural processes when sounds are adopted as proxy.
    Type of Medium: Online Resource
    Pages: VII, 127 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030821777
    Series Statement: Frontiers in Ecoacoustics, 1
    DDC: 333.9516
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Refuse and refuse disposal. ; Pollution. ; Environmental health. ; Waste Management/Waste Technology. ; Pollution. ; Environmental Health.
    Description / Table of Contents: 1. Utilisation of Recycled Slaughterhouse Wastes for Vegetable Cultivation in Rural India -- 2. Operation and Maintenance of Wash Infrastructure in Residential Schools in Tribal Belt of Maharashtra: A Case Study -- 3. Metal Resistant Bacteria in Animal Manure Induces Bacterial Resistance to Antibiotics: Their Co-occurrence in Compost, Soil and Water -- 4. Artificial Neural Network Model for Prediction of Methane Fraction in Landfill Gas from Pretreated Waste in Bioreactor Landfills -- 5. Effect of Gasification Zone Length on the Downdraft Gasifier Performance for High Ash Biomass -- 6. Utilisation of Natural Waste in Freeze-Thaw Affected Soil: A Comparative Analysis -- 7. Economic and Ecological Feasibility of Marble Powder in Cement Mortar -- 8. Use of Gas Turbine Operated by Municipal Solid Waste to Obtain Power and Cooling Assisted by Vapour Absorption Refrigeration System -- 9. Experimental Study on Recycled Polyethylene Terephthalate (PET) Bottle Fibre Reinforced Concrete -- 10. Estimation of Demolition Waste Using Waste Generation Rate and Logistic Flows in Surat, India -- 11. Identification of Potential Neighbourhood Constraints of Demolition Process: A Case Study -- 12. Sustainability of Natural Aggregates by Utilising CDW in Concrete -- 13. Experimental Study on Incorporation of Plastic Wastes as a Binding Material in Pervious Pavers -- 14. Biogas Development in India: A Sustainable Energy for Future -- 15. Study on the Effect of Load Resting Time on Recycled Brick Aggregate Cement Concrete -- 16. Energy Densification of Juice Waste Using Hydrothermal Carbonisation -- 17. Terracotta Membrane-based Microbial Fuel Cell with Algal Biocathode: A Low-Cost Alternative to Dairy Wastewater Treatment Coupled Electricity and Biomass Production -- 18. Upcycling Textile Waste Towards Green Nanocomposites -- 19. Reduction of Significant Aspects and Enhancement of Non-Significant Aspects for Hazardous Wastes in a Medical Electronics Manufacturing Firm -- 20. The Potential of Biogas Production from Water Hyacinth by Using Floating Drum Biogas Reactor -- 21. Influence of Initial pH on Bioleaching of Selected Metals from e-Waste Using Aspergillus niger -- 22. Column Leaching of Metals from PCB of End-of-Life Mobile Phone Using DTPA Under Oxidising Condition -- 23. Assessment of Sand Size on ECC Containing Waste Materials -- 24. Effect of Operating Parameters on Leachate Quantity and Quality Generated During Hydrolysis of Kitchen Waste -- 25. Comparative Performance Evaluation of Toxicity Assessment Tests on Waste Li-Ion Laptop Batteries -- 26. Recycling Construction and Demolition Waste: Potential Applications and the Indian Scenario -- 27. Biochemical Methane Potential and Kinetics of Parthenium hysterophorous with Different Food to Microorganisms (F/M) Ratios -- 28. Removal of Lead and Copper by Using Bentonite as an Adsorbent -- 29. Impact of Precipitation on Biodegradation of Fresh Municipal Solid Waste in Anaerobic Simulated Reactor -- 30. Scope of Renewable Energy Intervention for Energy Sufficiency in Nagaland -- Index.
    Abstract: In the developing countries, pollution through solid waste, sludge from water and wastewater treatment plants and pollution of natural water resources have become one of the grave issues. The root cause is population explosion, industrialization, urbanization and other anthropogenic activities. The increase rate of solid waste has become a major challenge for sustainable development of the environment. Poor management of solid waste and sludge from water and wastewater treatment plants may be the cause of health hazards and environmental problems. The book presents new methods and technologies to combat the aforementioned problems and focuses on the importance of using the recycled products. The technologies related to waste and sludge treatment are economical, eco-friendly and bring economic returns, and can be applied to most of the developing countries where waste treatment technologies, viz. composting, anaerobic digestion, recycling of plastic and agricultural waste in construction can be used. The aim of the book is to support everyone who is involved in academics, teaching, research related to solid waste management and water and wastewater treatment study in the leading academic and research organizations globally. This book will be of prodigious value to upcoming researchers, scholars, scientists and professionals in Environmental Science and Engineering fields, and global and local authorities and policy makers responsible for the management of solid wastes and sludge. Globally, universities can develop new prospectuses on sustainable and eco-friendly waste and sludge management, which are relating to the book’s theme. This book can also be of great source for designing and operation of waste reuse and recycling programmes.
    Type of Medium: Online Resource
    Pages: X, 334 p. 144 illus., 74 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030704636
    DDC: 363.728
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Food science. ; Agriculture. ; Economic geography. ; Botany. ; Environmental management. ; Food Science. ; Agriculture. ; Economic Geography. ; Plant Science. ; Environmental Management.
    Description / Table of Contents: chapter 1: Introduction -- chapter 2: Onion -- chapter3: Garlic -- chapter 4: Leek/stone leek/welsh onion -- chapter 5: Ajowan or bishop’s weed -- chapter 6: Celery seed -- chapter 7: Coriander -- chapter 8: Cumin seed or safaid jeera -- chapter 9: Fenugreek -- chapter 10: Mustard -- chpater11; Cassia and cumin -- chapter 12. Cinnamon or true cinnamon -- chapter 13: Clove -- chapter 14: Mace or nutmeg -- chapter 15: Allspice or pimenta or pimento -- chapter 16: Curry leaf -- chapter 17: Tamarind -- chapter 18: Asafoetida or asafetida -- chapter 19: Vanilla.
    Abstract: Spices can be classified as major spices, like Black pepper, Cardamom, Turmeric, Ginger etc, and minor spices and condiments, and tree spices. This book will discuss exclusively minor spices and condiments. Spices constitute a very important group of agricultural products, which, since antiquity, have been considered indispensable in the culinary art of flavoring foods. The history of spices is very much entwined with the history of mankind. And, some spice crops like Black pepper predominates in the family of spices. In fact, colloquially, it is called “King”of spices and, another, Cardamom, is called the “Queen”of spices. There is worthwhile amount of published work, on these in addition to Turmeric and Ginger. Both ISO (International Organization for Standardization) and ISI (Indian Standards Institution) (now BIS (Bureau of Indian Standards)) experts concluded, after considerable deliberations, that there is no clear-cut division between “spices” and “çondiments”, and, as such, they have been clubbed together. The term “Spices and Condiments” applies to such natural plant or vegetable products or mixtures, thereof, used in whole or ground form, mainly for imparting flavor, aroma and piquancy to foods and also for seasoning of foods and beverages like soups etc. A detailed survey of published literature proves that there are a number of minor spices, which have tremendous commercial potential, globally. And, an authentic book on these will not only serve as an important guide to the academic community, but, also provide a fillip to industry involved in value addition.
    Type of Medium: Online Resource
    Pages: XX, 226 p. 35 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030822460
    DDC: 641.3
    Language: English
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  • 8
    Keywords: Earth sciences. ; Water. ; Hydrology. ; Natural disasters. ; Sustainability. ; Physical geography. ; Earth Sciences. ; Water. ; Natural Hazards. ; Sustainability. ; Earth System Sciences.
    Description / Table of Contents: Integrated Water Resources Management of Thatipudi Command Area -- Streamflow health and variability analysis of Roanoke River, USA -- Enhancing water use efficiency through micro irrigation -- Hydrological modelling to study the impacts of climate and LULC change at basin scale: A review -- Reservoir Operation of Dharoi Dam: Fuzzy logic Approach -- Water Resource Management for Coal based Thermal Power Plant -- Estimation of Trap Efficiency And Useful Life of a Reservoir -- Evaluation of reservoir sedimentation using satellite data -- Hydraulic design of service nd emergency gates- A case study -- Regionalisation of watersheds using fuzzy c means clustering algorithm in west flowing rivers of Kerala.
    Abstract: This book explores many recent techniques including ANN, fuzzy logic, hydraulic models and IWRM utilized for integrated water resources management, a real challenge in India for obtaining high irrigation efficiency. The book deals with topics of current interest, such as climate change, floods, drought, and hydrological extremes. The impact of climate change on water resources is drawing worldwide attention these days; for water resources, many countries are already stressed and climate change along with burgeoning population, rising standard of living, and increasing demand are adding to the stress. Further, river basins are becoming less resilient to climatic vagaries. Fundamental to addressing these issues is hydrological modelling which is covered in this book Further, integrated water resources management is vital to ensure water and food security. Integral to the management is groundwater and solute transport. The book encompasses tools that will be useful to mitigate the adverse consequences of natural disasters.
    Type of Medium: Online Resource
    Pages: X, 288 p. 133 illus., 112 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030794002
    Series Statement: Water Science and Technology Library, 107
    DDC: 550
    Language: English
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  • 9
    Keywords: Immunology. ; Diseases. ; Therapeutics. ; Immunology. ; Diseases. ; Therapeutics.
    Description / Table of Contents: Section 1: Introduction -- Chapter 1: Introduction: An overview of host-directed therapies for tuberculosis -- Section 2: Targeting immunometabolism -- Chapter 2: Sirtuin deacetylases: Linking Mycobacterial infection and host metabolism -- Chapter 3:The mammalian target of rapamycin complex 1 (mTORC1): an ally of M. tuberculosis in host cells -- Chapter 4: HIF-1α as a potential therapeutic target for tuberculosis treatment -- Chapter 5: Nuclear receptors in host-directed therapies against tuberculosis -- Section 3: Enhancing anti-mycobacterial mechanisms -- Chapter 6: Autophagy as a target for host-directed therapy against tuberculosis -- Chapter 7: Metformin: a leading HDT candidate for TB -- Chapter 8: Statins as host-directed therapy for tuberculosis -- Chapter 9: Antimycobacterial attributes of mitochondria: An insight into host defense mechanisms -- Section 4: Targeting immune cells -- Chapter 10: Conventional and unconventional lymphocytes in immunity against Mycobacterium tuberculosis -- Chapter 11: Targeting inhibitory cells such as Tregs and MDSCs in the tuberculous granuloma -- Chapter 12: Targeting suppressor T cells -- Chapter 13: Neutrophil-mediated mechanisms as targets for host-directed therapies against tuberculosis -- Chapter 14: Type I interferon and interleukin-1 driven inflammatory pathways as targets for HDT in tuberculosis -- Chapter 15: Mucosal-associated invariant and Vγ9Vδ2 T cells -- Chapter 16: Airway epithelial cells.-Section 5: Preclinical models for assessing HDTs -- Chapter 17: In vitro models of human granuloma formation to analyze host-directed therapies -- Chapter 18: C3HeB/FeJ as a key mouse strain for testing host-directed therapies against tuberculosis -- Chapter 19: The Rabbit Model for Assessing Host-Directed Therapies for Tuberculosis -- Section 6: Clinical trials of HDTs and special considerations for study endpoints -- Chapter 20:Clinical trials of TB-HDT candidates -- Chapter 21:Outcomes for clinical trials of host-directed therapies for tuberculosis -- Chapter 22: Pharmacological considerations for clinical trials of host-directed therapies for tuberculosis.
    Abstract: This book discusses specific immune cell regulatory pathway(s), immune cell types, or other mechanisms involved in host responses to tuberculosis that can be potentially targeted for host-directed therapy (HDT). The pathways/mechanisms investigated are either protective – thus calling for pathway/factor enhancing drugs – or maladaptive – thus calling for pathway/factor inhibitory drugs. Discovery and development (pre-clinical and clinical) of candidate HDT agents will also be elucidated, as well as approaches for HDT of other diseases. The benefit to the reader will derive from learning about the biology of multiple host pathways involved in health and disease, how these pathways are disrupted or dysregulated during tuberculosis, and which druggable targets exist in these pathways. This book provides the reader with a roadmap of current and future directions of HDT against tuberculosis. Since the host pathways/factors involved in protective or maladaptive responses to tuberculosis are not disease-specific, information learned from the context of tuberculosis likely will be relevant to other infectious and non-infectious diseases.
    Type of Medium: Online Resource
    Pages: XIII, 332 p. 20 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030569051
    DDC: 571.96
    Language: English
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  • 10
    Keywords: Freshwater ecology. ; Marine ecology. ; Zoology. ; Ecology . ; Genetics. ; Freshwater and Marine Ecology. ; Zoology. ; Ecology. ; Genetics and Genomics.
    Description / Table of Contents: PART I. Yellow Perch (Perca flavescens) -- Spawning Characteristics of Yellow Perch During Periods of Water Level Fluctuations in a Hydropower Reservoir -- A Comparison of Aquaculture Production Methods for Optimizing Production of Fingerling Yellow Perch (Perca flavescens) -- Evaluation of a Statewide Yellow Perch Bag Limit for Michigan -- Distribution and Abundance of Pelagic Larval Yellow Perch in Lake St. Clair (USA/Canada) and Adjoining Waters -- PART II. Walleye (Stizostedion vitreum) -- Using Genomic Data to Guide Walleye Management in the Great Lakes -- Walleye Larviculture in Water Reuse Aquaculture Systems -- Effects of Parasiticidal Hydrogen Peroxide Treatments on Walleye Hatching Success in a Recirculating System -- Seasonal Movement Patterns and Distribution of Walleye in a Central Appalachian Hydropower Reservoir -- Managing Tribal Fisheries and Employees on the Reservation -- Can You Hear Me Now? Design Considerations for Large Lake, Multispecies Telemetry Projects -- PART III. Sauger (Stizostedion canadense) -- Sauger Restoration in the Upper Allegheny River Watershed, New York -- PART IV. Comparison of North American and European Percid Fisheries -- International Importance of Percids: Summary and Looking Forward.
    Abstract: Walleye, one of the most sought-after species of freshwater sport fishes in North America, has demonstrated appreciable declines in their numbers from their original populations since the beginning of the 20th century. Similarly, Yellow Perch, once the most commonly caught sport fish and an important commercial species in North America, have also shown declines. Compiling up-to-date information on the biology and management of Walleye, Sauger, and Yellow Perch, including research on systematics, genetics, physiology, ecology, movement, population dynamics, culture, recent case histories, and management practices, will be of interest to managers, researchers, and students who deal with these important species, particularly in light of habitat alterations, population shifts, and other biotic and abiotic factors related to a changing climate.
    Type of Medium: Online Resource
    Pages: XII, 328 p. 88 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030806781
    Series Statement: Fish & Fisheries Series, 41
    DDC: 577.6
    Language: English
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