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  • Springer  (38,165)
  • Nature Publishing Group  (4,219)
  • 2005-2009  (42,384)
  • 2005  (42,384)
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  • 2005-2009  (42,384)
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  • 1
    Unknown
    New York : Springer
    Keywords: Computer engineering. ; Computer security. ; Electronic data processing, Distributed processing.
    Pages: xx, 239 p.
    ISBN: 0-387-23917-0
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  • 2
    Publication Date: 2020-11-23
    Description: Abstract: The simultaneous solution of the Planck equation (involving the widely used “dual-band” technique) using two shortwave infrared (SWIR) bands allows for an estimate of the fractional area of the hottest part of an active lava flow (fh), and the background temperature of the cooler crust (Tc). The use of a high spectral and spatial resolution imaging spectrometer with a wide dynamic range of 15 bits (DAIS 7915) in the wavelength range from 0.501 to 12.67 µm resulted in the identification of crustal temperature and fractional areas for an intra-crater hot spot at Mount Etna, Italy. This study indicates the existence of a relationship between these Tc and fh extracted from DAIS and Landsat TM data. When the dual band equation system is performed on a lava flow, a logarithmic distribution is obtained from a plot of the fractional area of the hottest temperature versus the temperature of the cooler crust. An entirely different distribution is obtained over active degassing vents, where increases in Tc occur without any increase in fh. This result indicates that we can use scatter plots of Tc vs. fh to discriminate between different types of volcanic activity, in this case between degassing vents and lava flows, using satellite thermal data.
    Description: Published
    Description: 641–651
    Description: 4V. Processi pre-eruttivi
    Description: JCR Journal
    Description: open
    Keywords: Mount Etna ; remote-sensing ; lava-flow ; degassing vent ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 3
    Publication Date: 2021-03-01
    Description: On September 6, 2002, aML =5.6 earthquake, occurring some tens of kilometres offshore from the Northern Sicilian coast (Southern Tyrrhenian Sea), slightly damaged the city of Palermo and surroundings (degree 6 in the European Macroseismic Scale 1998). The macroseismic investigation of the shock and a detailed study of effects of the main earthquakes which affected Palermo in the past have been performed in order to evaluate the seismic response of the city. Moreover, the comparison of the recent event, which is instrumentally constrained, with historical earthquakes allows us to infer new insights on the seismogenic sources of the area, that seem located offshore in the Tyrrhenian sea. In the last 500 years, Palermo has never been completely destroyed but has suffered effects estimated between intensities 6 and 8 EMS-98 many times (1693, 1726, 1751, 1823, 1940, 1968, 2002). The damage scenarios of the analysed events have shown that damage distribution is strongly conditioned by soil response in the different parts of the city and by a high building vulnerability, mainly in the historical centre and in the south-eastern zone of the modern city. As a matter of fact, Palermo has always suffered greater effects than those reported for other nearby localities. The hazard assessment obtained using observed site intensities has shown that the probability of occurrence for intensity 8 (the strongest intensity observed in Palermo) exceeds 99% for 550 years, while the estimated mean return period is 152 ± 40 years. These results, in connection with building vulnerability due to the urban expansion before the introduction of seismic code, suggest that the city is exposed to a relatively high seismic risk.
    Description: Published
    Description: 525-543
    Description: partially_open
    Keywords: intensity ; damage ; earthquakes ; Italy ; macroseismics ; Palermo ; seismic hazard ; vulnerability ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 4
    Publication Date: 2017-04-03
    Description: We compare the results obtained from the modelling of EDM, GPS, levelling and tilt data measured in the first part of the 19911993 eruption at Etna to the InSAR data acquired during the second part. The geodetic changes are very marked in the first half of the eruption and constrain a deflation source located at a few kilometers of depth ( 3 km b.s.l.), in agreement with other independent geophysical evidence. SAR data, available during the second part of the eruption, were analysed for different time intervals in the second part of the eruption. The interpretation of SAR interferograms reveals a large-scale but less marked deflation of the volcano that could be caused by a deeper source. This second source is in accord with a second deeper anomaly revealed by recent seismic investigations. The combination of geodetic data modelling and SAR images suggests a complex plumbing system composed at least of two possible storage regions located at different depths.
    Description: Published
    Description: 1345-1357
    Description: partially_open
    Keywords: Geodesy ; SAR Interferometry ; ground deformation ; Mt. Etna volcano ; 04. Solid Earth::04.03. Geodesy::04.03.06. Measurements and monitoring ; 04. Solid Earth::04.03. Geodesy::04.03.07. Satellite geodesy ; 04. Solid Earth::04.03. Geodesy::04.03.09. Instruments and techniques
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  • 5
    Publication Date: 2017-04-04
    Description: Analysis of the historical records of Etnas eruptive activity for the past three centuries shows that, after the large 1669 eruption, a period of about 60 years of low-level activity followed. Starting from 1727, explosive activity (strombolian, lava fountaining and subplinian) at the summit crater increased exponentially to the present day. Since 1763, the frequency of flank eruptions also increased and this value remained high until 1960; afterward it further increased sharply. In fact, the number of summit and flank eruptions between 1961 and 2003 was four times greater than that of the pre-1960 period. This long-term trend of escalating activity rules out a pattern of cyclic behaviour of the volcano. We propose instead that the 16702003 period most likely characterises a single eruptive cycle which began after the large 1669 eruption and which is still continuing. On the basis of the eruptive style, two distinct types of flank eruptions are recognised: Class A and Class B. Class A eruptions are mostly effusive with associated weak strombolian activity; Class B eruptions are characterised by effusive activity accompanied by intense, long-lasting, strombolian and lava fountaining activity that produces copious tephra fallouts, as during the 2001 and 20022003 eruptions. Over the past three centuries, seven Class B eruptions have taken place with vents located mainly on the south-eastern flank, indicating that this sector of the volcano is a preferential zone for the intrusion of volatile-rich magma rising from the deeper region of the Etna plumbing system.
    Description: Published
    Description: 732-742
    Description: partially_open
    Keywords: Etna ; Historical record ; Summit activity ; Flank eruptions ; Eruptive behaviour ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 6
    Publication Date: 2017-04-04
    Description: The Monte Nuovo eruption is the most recent event that occurred at Phlegrean Fields (Italy) and lasted from 29 September to 6 October 1538. It was characterized by 2 days of quasi-sustained phreatomagmatic activity generating pumice-bearing pyroclastic density currents and forming a 130-m-high tuff cone (Lower Member deposits). The activity resumed after a pause of 2 days with two discrete Vulcanian explosions that emplaced radially distributed, scoria-bearing pyroclastic flows (Upper Member deposits). The juvenile products of Lower and Upper Members are, respectively, phenocryst-poor, light-coloured pumice and dark scoria fragments with K-phonolitic bulk compositions, identical in terms of both major and trace elements. Groundmass is formed by variable proportions of K-feldspar and glass, along with minor sodalite and Fe-Ti oxide present in the most crystallized samples. Investigations of groundmass compositions and textures were performed to assess the mechanisms of magma ascent, degassing and fragmentation along the conduit and implications for the eruptive dynamics. In pumice of the Lower Member groundmass crystal content increases from 13 to 28 vol% from the base to the top of the sequence. Products of the Upper Member consist of clasts with a groundmass crystal content between 30 and 40 vol% and of totally crystallized fragments. Crystal size distributions of groundmass feldspars shift from a single population at the base of the Lower Member to a double population in the remaining part of the sequence. The average size of both populations regularly increases from the Lower to the Upper Member. Crystal number density increases by two orders of magnitude from the Lower to the Upper Member, suggesting that nucleation dominated during the second phase of the eruption. The overall morphological, compositional and textural data suggest that the juvenile components of the Monte Nuovo eruption are likely to record variations of the magma properties within the conduit. The different textures of pumice clasts from the Lower Member possibly reflect horizontal gradients of the physical properties (P, T) of the ascending magma column, while scoriae from the second phase are thought to result from the disruption of a slowly rising plug crystallizing in response to degassing. In particular, crystal size distribution data point to syn-eruptive degassing-induced crystallization as responsible for the transition in eruptive style from the first to the second phase of the eruption. This mechanism not only has been proved to profoundly affect the dynamics of dome-forming calc-alkaline eruptions, but may also have a strong influence in driving the eruption dynamics of alkaline magmas of intermediate to evolved compositions.
    Description: Published
    Description: 601-621
    Description: reserved
    Keywords: Phlegrean Fields ; Vulcanian explosion ; Degassing ; Groundmass crystallization ; Eruption dynamics ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.02. Experimental volcanism ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
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  • 7
    Publication Date: 2017-04-04
    Description: In this work we present seismological and ground deformation evidence for the phase preparing the July 18 to August 9, 2001 flank eruption at Etna. The analysis performed, through data from the permanent seismic and ground deformation networks, highlighted a strong relationship between seismic strain release at depth and surface deformation. This joint analysis provided strong constraints on the magma rising mechanisms. We show that in the last ten years, after the 1991–1993 eruption, an overall accumulation of tension has affected the volcano. Then we investigate the months preceding the 2001 eruption. In particular, we analyse the strong seismic swarm on April 20–24, 2001, comprising more than 200 events (Mmax = 3.6) with prevalent dextral shear fault mechanisms in the western flank. The swarm showed a ca. NE-SW earthquake alignment which, in agreement with previous cases, can be interpreted as the response of the medium to an intrusive process along the approximately NNW-SSE volcano-genetic trend. These mechanisms, leading to the July 18 to August 9, 2001 flank eruption, are analogous to ones observed some months before the 1991–1993 flank eruption and, more recently, in January 1998 before the February-November 1999 summit eruption.
    Description: Published
    Description: 1469-1487
    Description: partially_open
    Keywords: Ground deformation ; volcano seismology ; Mt. Etna Volcano ; intrusive mechanism ; 04. Solid Earth::04.03. Geodesy::04.03.01. Crustal deformations ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 8
    Publication Date: 2017-04-04
    Description: Ground deformation occurring on the southern flank of Mt Etna volcano during the JulyAugust 2001 eruption was monitored by GPS measurements along an EW profile crossing the fissure system. This profile was measured eight times during the eruption, using the 'stop and go' semi-kinematic technique. Horizontal and vertical displacements between GPS surveys are reported for each station. The most significant event is a deformation episode occurring during the first week of the eruption, between 2527 July. Displacements were measured on benchmarks close to the eruptive fissure and the tensile 1989 fracture. Data inversions for measured displacements were performed using the Okada model. The model shows the narrowing of the 2001 dyke accompanied by a dextral dislocation along an east-dipping fault, parallel to the 1989 fracture.
    Description: Published
    Description: 336-341
    Description: partially_open
    Keywords: GPS ; Ground deformation ; Modelling ; Volcano monitoring ; 04. Solid Earth::04.03. Geodesy::04.03.07. Satellite geodesy ; 04. Solid Earth::04.03. Geodesy::04.03.09. Instruments and techniques ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
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  • 9
    Publication Date: 2017-04-04
    Description: The 200203 Mt Etna flank eruption began on 26 October 2002 and finished on 28 January 2003, after three months of continuous explosive activity and discontinuous lava flow output. The eruption involved the opening of eruptive fissures on the NE and S flanks of the volcano, with lava flow output and fire fountaining until 5 November. After this date, the eruption continued exclusively on the S flank, with continuous explosive activity and lava flows active between 13 November and 28 January 2003. Multi-disciplinary data collected during the eruption (petrology, analyses of ash components, gas geochemistry, field surveys, thermal mapping and structural surveys) allowed us to analyse the dynamics of the eruption. The eruption was triggered either by (i) accumulation and eventual ascent of magma from depth or (ii) depressurisation of the edifice due to spreading of the eastern flank of the volcano. The extraordinary explosivity makes the 200203 eruption a unique event in the last 300 years, comparable only with La Montagnola 1763 and the 2001 Lower Vents eruptions. A notable feature of the eruption was also the simultaneous effusion of lavas with different composition and emplacement features. Magma erupted from the NE fissure represented the partially degassed magma fraction normally residing within the central conduits and the shallow plumbing system. The magma that erupted from the S fissure was the relatively undegassed, volatile-rich, buoyant fraction which drained the deep feeding system, bypassing the central conduits. This is typical of most Etnean eccentric eruptions. We believe that there is a high probability that Mount Etna has entered a new eruptive phase, with magma being supplied to a deep reservoir independent from the central conduit, that could periodically produce sufficient overpressure to propagate a dyke to the surface and generate further flank eruptions.
    Description: Published
    Description: 314-330
    Description: partially_open
    Keywords: Multi-disciplinary study ; Mount Etna ; 2002–03 eruption ; Eccentric eruptions ; Flank activity ; Etna feeding system ; Volcanic processes ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
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  • 10
    Publication Date: 2017-04-04
    Description: An anisotropic attenuation law, based on an anisotropic characterization of intensity distribution for seismogenic zones, is proposed. This approach, that distinguishes itself for its consistency to the observed data, initially reconfigured by filtering procedures, is particularly suitable for seismic hazard evaluation.
    Description: Published
    Description: 707-714
    Description: partially_open
    Keywords: Attenuation law ; virtual intensity distribution ; seismic hazard ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 11
    Publication Date: 2017-04-04
    Description: A modelling of the observed macroseismic intensity of historical and instrumental earthquakes in southern Spain is proposed, with the aim of determining the macroseismic parameters for seismic hazard evaluation in a region in which the characterization of intensity distribution of seismic events shows different levels of difficulty referable to the complex faults system of the area in study. The adopted procedure allows an analytical determination of epicenters and principal attenuation directions of earthquakes with a double level of verification with reference to the maximum shaking area and structural lineaments of the region, respectively. The analyses, carried out on a suitable number of events, highlight, therefore, some elements for a preliminary characterization of a seismic zonation on the basis of the consistency between seismic intensity distribution of earthquakes and corresponding structural framework.
    Description: Published
    Description: 747-760
    Description: partially_open
    Keywords: Attenuation directions ; southern Spain ; macroseismic intensity ; virtual intensity ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
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  • 12
    Publication Date: 2017-04-04
    Description: Flank instability and collapse are observed at many volcanoes. Among these, Mt. Etna is characterized by the spreading of its eastern and southern flanks. The eastern spreading area is bordered to the north by the EW-trending Pernicana Fault System (PFS). During the 20022003 Etna eruption, ground fracturing along the PFS migrated eastward from the NE Rift, to as far as the 18 km distant coastline. The deformation consisted of dextral en-echelon segments, with sinistral and normal kinematics. Both of these components of displacement were one order of magnitude larger (~1 m) in the western, previously known, portion of the PFS with respect to the newly surveyed (~9 km long) eastern section (~0.1 m). This eastern section is located along a pre-existing, but previously unknown, fault, where displaced man-made structures give overall slip rates (11.9 cm/year), only slightly lower than those calculated for the western portion (1.42.3 cm/year). After an initial rapid motion during the first days of the 20022003 eruption, movement of the western portion of the PFS decreased dramatically, while parts of the eastern portion continued to move. These data suggest a model of spreading of the eastern flank of Etna along the PFS, characterized by eruptions along the NE Rift, instantaneous, short-lived, meter-scale displacements along the western PFS and more long-lived centimeter-scale displacements along the eastern PFS. The surface deformation then migrated southwards, reactivating, one after the other, the NNWSSE-trending Timpe and Trecastagni faults, with displacements of ~0.1 and ~0.04 m, respectively. These structures, along with the PFS, mark the boundaries of two adjacent blocks, moving at different times and rates. The new extent of the PFS and previous activity over its full length indicate that the sliding eastern flank extends well below the Ionian Sea. The clustering of seismic activity above 4 km b.s.l. during the eruption suggests a deep décollement for the moving mass. The collected data thus suggests a significant movement (volume 〉1,100 km3) of the eastern flank of Etna, both on-shore and off-shore.
    Description: Published
    Description: 417-430
    Description: partially_open
    Keywords: Volcano spreading ; Fracturing ; Mt. Etna ; Pernicana Fault System ; NE Rift ; 04. Solid Earth::04.04. Geology::04.04.09. Structural geology ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 13
    Publication Date: 2017-04-04
    Description: We have characterized pumice products belonging to the climactic phase of the 800-year-b.p. Quilotoa eruption. Bulk rock compositions, petrography, mineral, and glass chemistry and textural investigations were performed on the three end-member pumice types, namely white, gray, and mingled pumices. All the investigated pumice clasts are dacites characterized by the same bulk rock composition and mineralogical assemblage, but glass compositions and bulk textures change according to different pumice types. White pumice has higher crystallinity (~48 wt%), abundant euhedral pheno/microphenocrysts, no groundmass microlites, the most evolved glass compositions (7478 wt% SiO2), and heterogeneous vesicle populations marked by deformed and highly coalesced vesicles with thin walls. Gray pumice exhibits lower crystallinity (2936 wt%), abundant broken and/or resorbed crystals, ubiquitous groundmass phenocryst fragments and microlites, the widest range of glass compositions (6978 wt% SiO2), and quite homogeneous poorly deformed and coalesced vesicles with thicker walls. Mingled pumices are characterized by the alternation of bands or patches with white and gray pumice compositional and textural characteristics. We attribute heterogeneities in glass compositions and crystal and vesicle textures to processes occurring within volcanic conduits as magma is ascending to the surface. In particular, the above observations and results are consistent with an origin of a gray magma by heating of the original white magma in a strongly sheared region of the conduit because of a mechanism of viscous dissipation and crystal grinding and resorption at the conduit walls. The less viscous gray magma, therefore, would enable the onset and preservation of a high mass flux of the eruption otherwise difficult to explain for highly viscous crystal-rich dacitic magmas.
    Description: Published
    Description: 307-321
    Description: partially_open
    Keywords: Plinian eruption ; Crystal-rich magma ; Crystal grinding ; Pumice types ; Viscous dissipation ; 04. Solid Earth::04.08. Volcanology::04.08.03. Magmas ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
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  • 14
    Publication Date: 2017-04-04
    Description: The anisotropic modelling of intensity distribution, affected by the construction of macroseismic planes, allows an analysis of the influence of each point of observed intensity on the analytical determination of epicenter and of the principal attenuation directions. Such a procedure is a vital aid in the cases in which the observed intensity points, that, for location or joined intensity level, are not consistent with an anisotropic model of intensity attenuation. A suitable filtering on intensity levels associated with the points of the intensity map, for a better modelling of observed intensity distribution, is proposed with the aim of a better seismic hazard evaluation
    Description: Published
    Description: 683-697
    Description: partially_open
    Keywords: Macroseismicity ; observed intensity filtering ; macroseismic planes ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
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  • 15
    Publication Date: 2017-04-04
    Description: This paper shows the results of a detailed reprocessing of aeromagnetic data,obtained by the downward projection to the seabed. The area of interest is centered over the Tyrrhenian Basin,whose bathymetric –topographic lay-out is characterized by a somewhat irregular trend.The origin of the intense depth variations depends on the Tyrrhenian structural setting,that is associated with the presence of several tectonic lineaments,seamounts or volcanic islands.The data were characterized by good quality and dense sam- pling,but they have been reprocessed in order either to solve some problems in the original compilation,and to reduce the distor- tion of the geomagnetic anomaly field caused by the difference of distance between the survey level and the magnetic source.The reprocessed magnetic map is proposed as an e ffective analysis tool for the Tyrrhenian area that is characterized by high susceptibility lithotypes.Downward projection of the aeromagnetic data by BTM algorithm increases the de finition of the anomalous magnetic signal without distortions in the geometric pattern of the field,thus showing a more stable and effective association between the magnetic anomalies and their geological sources.This effect is particularly true for high frequency anomalies that are directly comparable after the topographic projection because the depth filtering effect is attenuated.Moreover,the BTM method has been applied for the first time to a regional scale survey that shows substantial advantages because no fictitious anomalies in the high frequency sector of the spectrum were generated.This has been a typical effect of the traditional downward projection methods widely used before.The final result is a BTM anomaly map that is able to show the structural connections between the geological magnetic sources of the Tyrrhenian Sea area.
    Description: Published
    Description: 265-277
    Description: reserved
    Keywords: Potential methods,marine geomagnetism,downward continuation,Tyrrhenian Sea ; 04. Solid Earth::04.02. Exploration geophysics::04.02.04. Magnetic and electrical methods
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  • 16
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Standard microarrays measure mRNA abundance, not mRNA synthesis, and therefore cannot identify the mechanisms that regulate gene expression. We have developed a method to overcome this limitation by using the salvage enzyme uracil phosphoribosyltransferase (UPRT) from the protozoan Toxoplasma ...
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  • 17
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Gluconobacter oxydans is unsurpassed by other organisms in its ability to incompletely oxidize a great variety of carbohydrates, alcohols and related compounds. Furthermore, the organism is used for several biotechnological processes, such as vitamin C production. To further our understanding of ...
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  • 18
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 253-260 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Parallel functional modules are separate sets of proteins in an organism that catalyze the same or similar biochemical reactions but act on different substrates or use different cofactors. They originate by gene duplication during evolution. Parallel functional modules provide versatility and ...
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  • 19
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Most of the published quantitative models in biology are lost for the community because they are either not made available or they are insufficiently characterized to allow them to be reused. The lack of a standard description format, lack of stringent reviewing and authors' carelessness are the ...
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  • 20
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Lactobacillus sakei is a psychrotrophic lactic acid bacterium found naturally on fresh meat and fish. This microorganism is widely used in the manufacture of fermented meats and has biotechnological potential in biopreservation and food safety. We have explored the 1,884,661-base-pair (bp) circular ...
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  • 21
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1534-1541 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety of organs has generated much excitement over the possible use of hES cells in therapeutic applications. Of great interest are organs derived from definitive endoderm, such as the pancreas. We have ...
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  • 22
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1503-1508 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Expression profiling of time-series experiments is widely used to study biological systems. However, determining the quality of the resulting profiles remains a fundamental problem. Because of inadequate sampling rates, the effect of arrest-and-release methods and loss of synchronization, the ...
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  • 23
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1037-1039 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] As the $30 billion monoclonal antibody (mAb) market moves from murine-based to chimeric and fully human products, it grows at a compounded clip of nearly 20% per year (see ). This spectacular growth—Synagis (pavilivizumb; MedImmune, Gaithersburg, Maryland), Herceptin (trastuzumab; ...
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    Nature biotechnology 23 (2005), S. 1045-1045 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: The paper by Kazuya Watanabe and colleagues published in the January issue (Nat. Biotechnol. 23, 88–93, 2005) is framed both in the paper itself and in the accompanying News & Views by Jo Handelsman (Nat. Biotechnol. 23, 38–39, 2005) as an astute, general genetic ...
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    Nature biotechnology 23 (2005), S. 1045-1046 
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    Notes: [Auszug] Watanabe and colleagues respond: de Lorenzo outlines some possible limitations of the substrate-induced gene expression screening (SIGEX) method. Although we discussed many of the points in his letter in our paper, it is worth reiterating them to emphasize the challenges faced in designing a ...
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    Nature biotechnology 23 (2005), S. 1046-1046 
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    Notes: [Auszug] To the editor: Your editorial in the June issue (Nat. Biotechnol. 23, 633, 2005) on the biotech open source movement skirted round one critical difference between biotech and the software industry whose 'open source' movement Richard Jefferson seeks to emulate. Writing software is cheap and can be ...
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    Nature biotechnology 23 (2005), S. 1019-1019 
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    Notes: [Auszug] Nanotech-based sequencing Roche and 454 Life Sciences, a subsidiary of CuraGen, offer a nanotechnology-based genome sequencing system that allows a single instrument to produce over 20 million nucleotide bases per 4-hour run, totaling more than 100 times the capacity of instruments using current ...
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    Nature biotechnology 23 (2005), S. 903-903 
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    Notes: [Auszug] BiDil is a recently approved therapy indicated for congestive heart failure patients already taking standard treatments. It is not a new drug. It is a combination of two existing drugs—isosorbide dinitrate and hydralazine—already marketed seperately as generics. What is new about BiDil ...
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    Nature biotechnology 23 (2005), S. 907-907 
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    Notes: [Auszug] The Tokyo-based pharmaceutical development firm GNI announced its merger with Shanghai Genomics on June 20, marking the first such partnership between a Japanese and a Chinese biotech in over a decade. The newly formed venture has a research staff of more than 80 in Japan, China and England, and a ...
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    Nature biotechnology 23 (2005), S. 913-913 
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    Notes: [Auszug] During the 13 years that he was CEO of Human Genome Sciences (HGS), William Haseltine rarely traveled for pleasure. He was even less mobile before his tenure at the Rockville, Maryland–based genomics firm that he founded in 1992; as a cancer and AIDS researcher at the Dana Farber Cancer ...
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    Nature biotechnology 23 (2005), S. 914-914 
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    Notes: [Auszug] Although private financing and overall funding remain relatively stable, investor interest in biotech is a shadow of a year ago, when the initial public offering (IPO) market had just come off the best two quarters of this window. The BioCentury 100 Index has fallen by a little more than 10%, and ...
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    Nature biotechnology 23 (2005), S. 946-947 
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    Notes: [Auszug] In just a few years, small interfering RNA (siRNA) has emerged as a powerful technology to specifically knockdown genes in mammalian cells both for functional analysis and for therapeutic purposes. The success of this approach, also called RNA interference (RNAi), hinges on the affinity of an siRNA ...
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    Notes: [Auszug] A catalog of all human protein-protein interactions would provide scientists with a framework to study protein deregulation in complex diseases such as cancer. Here we demonstrate that a probabilistic analysis integrating model organism interactome data, protein domain data, genome-wide gene ...
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    Nature biotechnology 23 (2005), S. 1325-1325 
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    Notes: [Auszug] In September, Lester Crawford resigned as commissioner of the US Food and Drug Administration (FDA), leaving a leadership vacuum that was quickly filled by President Bush's appointment of Andrew von Eschenbach, formerly the director of the National Cancer Institute (NCI), as acting commissioner. ...
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    Nature biotechnology 23 (2005), S. 1327-1328 
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    Notes: [Auszug] Officials at Sandoz, the generic branch of Novartis of Basel, filed a rare type of lawsuit with the US District Court on September 13. The company wants the court to force the US Food and Drug Administration (FDA) to rule on—preferably, approve—Omnitrope, its follow-on version of ...
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    Nature biotechnology 23 (2005), S. 1329-1330 
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    Notes: [Auszug] Cabilly patent invalidated Genentech's stronghold on monoclonal antibody production techniques may slip if a recent US Patent and Trademark Office's (USPTO) initial ruling is upheld. In late September, the USPTO rejected the company's ubiquitous Cabilly 2 patent on the grounds that it extends the ...
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    Nature biotechnology 23 (2005), S. 1332-1332 
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    Notes: [Auszug] In a risk-averse market, biotech stock market indices showed sluggish growth, being outperformed by broader market indicators. Venture capital funding remained relatively stable but public biotechs were able to take advantage of debt, private investment in public equitities (PIPEs) and follow-on ...
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    Nature biotechnology 23 (2005), S. 1331-1331 
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    Notes: [Auszug] Is Chicago artist-writer-philosopher Eduardo Kac ahead of his time or just nuts? In the foreword of his new book, Art Institute of Chicago art historian James Elkins makes the case for the former. Elkins acknowledges, however, that not everybody agrees on this point and cites the negative critiques ...
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    Nature biotechnology 23 (2005), S. 1333-1335 
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    Notes: [Auszug] The Human Genome Project cost nearly $3 billion, and no one would quibble with the price tag. The scientific benefit is incalculable. But translating the potential of genomics into tangible benefits for basic and biomedical research, not to mention personalized medicine, will require vast ...
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    Nature biotechnology 23 (2005), S. 1343-1343 
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    Notes: [Auszug] To the editor: We were greatly disturbed to read your editorial in the August issue (Nat. Biotechnol. 23, 903, 2005) which made disparaging comments about BiDil, a new heart failure medication for blacks that has been shown clearly to be safe and effective. Despite misleading claims in your ...
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    Nature biotechnology 23 (2005), S. 1343-1344 
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    Notes: [Auszug] Nature Biotechnology responds to BiDil's impact: In citing their three 'crucial' facts, Puckrein and Yang sidestep the main point of our editorial: BiDil is a poor example of targeted medicine. As far as we know, skin pigmentation has not yet been genetically linked to (less still shown to be an ...
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    Nature biotechnology 23 (2005), S. 801-804 
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    Notes: [Auszug] With relatively little fanfare, the current Good Tissue Practices (cGTP) Final Rule finally came into force in the United States in May. Under its legal authority, the US Food and Drug Administration (FDA) now inspects entities involved in the manufacture of human cells, tissues, and cellular and ...
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    Nature biotechnology 23 (2005), S. 1345-1345 
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    Notes: [Auszug] Lok and Brent respond: Our simulation program, Moleculizer, calculates cellular reaction networks by allowing protein complexes to form in silico. From the correspondence of Hlavacek and colleagues, we take two main points. They argue that there are advantages to generating reaction networks ...
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    Nature biotechnology 23 (2005), S. 1085-1087 
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    Notes: [Auszug] In a stroke of serendipity, researchers investigating plant responses to the explosive TNT have stumbled upon a transporter gene that may obviate the need for bacterial selectable markers in the generation of transgenic plants. As described in this issue, Mentewab and Stewart were studying the ...
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    Nature biotechnology 23 (2005), S. 1346-1348 
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    Notes: [Auszug] Fabian et al. respond: Buolamwini and Kamath suggest that the data presented in our manuscript lack statistical validation and are not sufficiently quantitative to justify some of our conclusions. In particular, they state that the validation of our technology, which included a detailed comparison ...
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    Nature biotechnology 23 (2005), S. 1348-1349 
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    Notes: [Auszug] To the editor: Monitoring the evolution of plant transgenic science is hampered by the difficulty of obtaining accurate bibliometric information compared with equivalent animal and microbial research. This is mostly due to the imprecision of the term 'transformation,' which is generally used to ...
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    Nature biotechnology 23 (2005), S. 1353-1355 
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    Notes: [Auszug] Tissue engineering is having difficulty transitioning from a development-stage industry to one with a successful product portfolio. Currently, many of the key international tissue-engineering centers focus almost exclusively on the biology of tissue culture to the detriment of manufacturing and ...
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    Nature biotechnology 23 (2005), S. 1357-1357 
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    Notes: [Auszug] In Liberation Biology, Ronald Bailey grapples with many of the key ethical issues raised by our advances in biotech. He seeks to counterbalance the bleak vision of the future, akin to Huxley's Brave New World, predicted by Leon Kass, Francis Fukuyama and other 'bioconservatives.' Bailey's own ...
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    Nature biotechnology 23 (2005), S. 1356-1356 
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    Notes: [Auszug] Those of us who invest in stocks can repeat the major indexes of market performance in our sleep because they are ubiquitous in the financial media. The S&P, FTSE, CAC, DAX and Nikkei are acronyms known worldwide for their alleged measure of the US, UK, French, German and Japanese stock ...
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    Nature biotechnology 23 (2005), S. 1359-1366 
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    Notes: [Auszug] The landscape in vaccine manufacturing has changed radically over the past 30 years. In 1967, over a dozen licensed vaccine manufacturers operated in the United States alone. This number has since collapsed through mergers and exits to barely a handful. Low profit margins, the introduction in 1980 ...
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    Nature biotechnology 23 (2005), S. 659-661 
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    Notes: [Auszug] The extent to which biomedical research is subject to the patent laws continues to trouble scientists and decision makers in the pharmaceutical and biotech industries. Many hope that the Supreme Court will clarify this issue when it decides this summer Integra LifeSciences v. Merck KGaA, a case ...
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    Nature biotechnology 23 (2005), S. 1378-1379 
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    Notes: [Auszug] Excessive use of antibiotics has increased resistance of many microbes to these drugs. In a recent issue of Nature, Hoffman et al. show that too little antibiotic can also be detrimental. They demonstrate that subinhibitory levels of the aminoglycoside-class antibiotic tobramycin increase biofilm ...
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    Nature biotechnology 23 (2005), S. 1379-1380 
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    Notes: [Auszug] In antiquity, Crete was known as the crossroads of the Mediterranean. Minoan culture was enriched and invigorated by its diverse mix of cultures and thriving commerce with Africa, Europe and Asia. This ancient crossroads was somewhat fitting therefore as a backdrop for a conference that sought to ...
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    Nature biotechnology 23 (2005), S. 686-687 
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    Notes: [Auszug] A robust and reproducible means of specifically correcting 'faulty' bases in genes has been a longtime goal in genetic medicine. In a recent issue of Nature, Urnov et al. use four-finger zinc finger chimeric endonucleases (ZFNs) to achieve highly efficient and permanent alteration of the gene ...
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    Nature biotechnology 23 (2005), S. 967-973 
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    Notes: [Auszug] The ability to achieve site-specific manipulation of the mammalian genome has widespread implications for basic and applied research. Gene targeting is a process in which a DNA molecule introduced into a cell replaces the corresponding chromosomal segment by homologous recombination, and thus ...
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    Nature biotechnology 23 (2005), S. 766-767 
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    Notes: [Auszug] Ambitious plans by the European Commission (EC) to double research spending during 2007–2013 were quietly shelved during the run-up to a political summit of EU heads of state on June 15–16. The present budgetary impasse, combined with an ongoing paucity of funding, has cast doubts over ...
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    Nature biotechnology 23 (2005), S. 1399-1405 
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    Notes: [Auszug] Inhibition of gene expression through RNA interference (RNAi) is emerging as a powerful experimental tool for gene function and target validation studies. The potential uses of this technology seem unlimited, extending to the prevention and therapy of human diseases. However, recent work ...
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    Nature biotechnology 23 (2005), S. 635-635 
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    Notes: [Auszug] The US biotech market may be losing its former center-stage position for European companies, judging by the $1.6 billion cash acquisition of Transkaryotic Therapies, of Wayne, Pennsylvania, by the mid-sized European pharmaceuticals firm Shire of Basingstoke, UK. An increasingly difficult ...
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    Nature biotechnology 23 (2005), S. 639-639 
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    Notes: [Auszug] Some of the most anticipated results at this year's American Society of Clinical Oncology (ASCO) meeting were from phase 3 trials of two targeted therapies with multiple mechanisms of action—also known as multi-kinase inhibitors. These therapies are rapidly gaining ground in less common ...
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    Nature biotechnology 23 (2005), S. 689-689 
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    Notes: [Auszug] Cells strike a pose Weiss and colleagues have designed an artificial cellular communications network in which signaling among cells leads to the formation of various supracellular patterns. Their system includes Escherichia coli 'sender' cells genetically engineered to express the LuxI enzyme, ...
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    Nature biotechnology 23 (2005), S. 759-760 
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    Notes: [Auszug] Biotech is big business these days, and record numbers of PhDs are trading the ivory tower for industry. The 1,500 biotech companies in the United States alone have combined revenues exceeding $40 billion, according to the Biotechnology Industry Organization—and they need skilled ...
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    Nature biotechnology 23 (2005), S. 731-735 
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    Notes: [Auszug] In the chicken immune system, gene conversion, a type of homologous recombination, primarily contributes to diversification of the immunoglobulin gene. Here, we report on the rapid generation of specific monoclonal antibodies using the chicken DT40 B-cell line undergoing gene conversion. We ...
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    Notes: [Auszug] Accurate determination of functional interactions among proteins at the genome level remains a challenge for genomic research. Here we introduce a genome-scale approach to functional protein annotation—phylogenomic mapping—that requires only sequence data, can be applied equally well to ...
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    Nature biotechnology 23 (2005), S. 699-708 
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    Notes: [Auszug] Human embryonic stem cells have been defined as self-renewing cells that can give rise to many types of cells of the body. How and whether these cells can be manipulated to replace cells in diseased tissues, used to screen drugs and toxins, or studied to better understand normal development, ...
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    Nature biotechnology 23 (2005), S. 509-509 
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    Notes: [Auszug] Even as the environment for going public remains hostile to most biotech companies and their investors, some are discovering that favorable financing alternatives still exist. A spate of recent acquisitions and a continuation of early-stage deal making signify that there are still appealing ways ...
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    Nature biotechnology 23 (2005), S. 513-513 
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    Notes: [Auszug] On May 3, the first case appealed to the US Court of Appeals for the Federal Circuit concerning the patentability of expressed sequence tags (ESTs) is due to start, following a dispute between St. Louis, Missouri-based Monsanto and the US Patent and Trademark Office (USPTO). The case is likely to ...
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    Nature biotechnology 23 (2005), S. 287-289 
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    Notes: [Auszug] To the editor: In last year's March issue (Nat. Biotechnol. 22, 267–268, 2004), Frank Rainer Schmidt provided an example of past research relevant to the current topic of RNA interference (RNAi). As a follow-up, we would like to briefly review previous work at Calgene (Davis, CA, USA; now ...
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    Nature biotechnology 23 (2005), S. 1221-1226 
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    Notes: [Auszug] Even casual observers of the biopharmaceutical industry are aware of a mutually beneficial relationship among small, discovery-oriented biotech companies and major drug companies. While one group acts as an engine of innovation, the other brings the financing, development expertise and regulatory ...
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    Nature biotechnology 23 (2005), S. 355-360 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Fluorescent proteins that exhibit Förster resonance energy transfer (FRET) have made a strong impact as they enable measurement of molecular-scale distances through changes in fluorescence. FRET-based approaches have enabled otherwise intractable measurements of molecular concentrations, ...
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    Notes: [Auszug] Peptides derived from almost all proteins, including disease-associated proteins, can be presented on the cell surface as peptide–human leukocyte antigen (pHLA) complexes. T cells specifically recognize pHLA with their clonally rearranged T-cell receptors (TCRs), whose natural affinities are ...
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    Nature biotechnology 23 (2005), S. 153-153 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Until recently, biotech and pharmaceutical companies have had little reason to heed calls for greater transparency in the disclosure data from their clinical trials. That all changed last year when New York State attorney general Eliot Spitzer filed a high-profile lawsuit against GlaxoSmithKline ...
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    Nature biotechnology 23 (2005), S. 163-163 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] “It is not biotech that's dangerous,” claims Margaret Atwood, her sparkly blue eyes betraying the intensity of her conviction. “It is people's fears and desires.” Her latest book, Oryx and Crake, paints a grim picture of the future in which a genetically engineered virus has ...
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    Nature biotechnology 23 (2005), S. 164-164 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Last year's big surprise was that venture capital investment in biotech was greater than in 2000, up to $5.3 billion. Initial public offerings (IPOs) didn't fair nearly so well, but still provided the second largest amount (∼$2.5 billion) raised for biotech in more than a decade. ...
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    Nature biotechnology 23 (2005), S. 165-167 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A new sort of anti-GMO protest broke out last December in Argentina at the tenth anniversary United Nations (UN) conference on climate change. Protestors were not grousing about food this time, but about genetically modified (GM) trees, which, under the Kyoto Protocol set to go into effect this ...
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    Nature biotechnology 23 (2005), S. 1315-1315 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Nat. Biotechnol. 23, 1177–1180 (2005) On p. 1180, line 4, the reverse primer to amplify the gene encoding Atwbc19 was given as (5′-TGTCCCCGTTTTTATCCAAG-3′). The reverse primer used was 5′-GTCAGCGAGCTCTCACGTCCTCTTATTCCTGC-3′, which contains a SacI ...
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    Nature biotechnology 23 (2005), S. 1243-1247 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] In the time of Isaac Newton (1643–1727), a prominent scientist could follow advances in multiple fields of knowledge—as far apart from each other as mathematics, astronomy, physics, history and theology. It took a talent of Newton's caliber, of course, to contribute to several of them ...
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    Nature biotechnology 23 (2005), S. 1316-1316 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Imaging family Olympus's new cell* family is a range of imaging systems and software tools providing simple image acquisition and documentation to complete solutions for live cell imaging. The high-powered and mutually compatable imaging products combine excellent performance with ...
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    Nature biotechnology 23 (2005), S. 186-187 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Bacteria of the genus Gluconobacter exhibit so-called oxidative fermentation, or incomplete oxidation, a highly unusual metabolic feature that has been exploited industrially for decades in the production of vitamin C (ascorbic acid), gluconic acid and dihydroxyacetone. In this issue, Prust et al. ...
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    Nature biotechnology 23 (2005), S. 489-491 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Although the development of pharmaceutical and biotechnological end products has been traditionally based on patents, biomedical research in academia comes from the very different tradition of open science; that is, relatively unrestricted access to fundamental knowledge developed by previous ...
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    Nature biotechnology 23 (2005), S. 1257-1268 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Not all adaptive immune systems use the immunoglobulin fold as the basis for specific recognition molecules: sea lampreys, for example, have evolved an adaptive immune system that is based on leucine-rich repeat proteins. Additionally, many other proteins, not necessarily involved in adaptive ...
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    Nature biotechnology 23 (2005), S. 1249-1256 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] We have analyzed issues of reliability in studies in which comparative genomic approaches have been applied to the discovery of regulatory elements at a genome-wide level in vertebrates. We point out some potential problems with such studies, including difficulties in accurately identifying ...
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    Nature biotechnology 23 (2005), S. 272-273 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] A new report, BioImpact, backed by European bioindustry lobbies, sets out the socioeconomic benefits of biotech-based therapies in ten disease areas but fails to include enough economic information to back its case. This reflects a widespread dearth of data that formally captures the cost ...
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    Nature biotechnology 23 (2005), S. 309-310 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] The production of genetically modified crops that could alleviate hunger and malnutrition in developing countries may be impeded by patents on the DNA components or on the techniques for introducing DNA into the plant genome and regenerating plants. Currently, the most widely used method of gene ...
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    Nature biotechnology 23 (2005), S. 366-366 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Nat. Biotechnol. 23, 13–15 (2005) On page 13, column 3, paragraph 4, line 16, The following, “the country's pharmaceutical exports were worth around $1.27 billion in 2004 with generics accounting for 6%” should have read “the country's total pharmaceutical output was ...
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    Nature biotechnology 23 (2005), S. 369-369 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Recent patent applications in proteomics Table ...
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    Nature biotechnology 23 (2005), S. 159-159 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Invitrogen's acquisition of Chinese competitor BioAsia is the first major acquisition by a foreign company in the life science sector. The move has been made possible by recent changes in the Chinese legal framework surrounding mergers and acquisitions (M&A) by foreign companies in China. ...
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    Nature biotechnology 23 (2005), S. 171-172 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Humans seem innately to wish to transcend their physical and mental limitations. Consider, for example, the eternal quest for a Fountain of Youth that will confer immortality. More modest, real-world instrumentalities today include anabolic steroids, growth hormones, erythropoietin and blood ...
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    Nature biotechnology 23 (2005), S. 175-179 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Although capital markets for financing biotech companies typically go up and down like a roller coaster, the number of initiatives launched by individual states to attract biotechnology to its borders has steadily climbed over the past few years. “States are always looking for money, now more ...
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    Nature biotechnology 23 (2005), S. 21-22 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Human genetics studies of complex traits have been facilitated by the completion of the human genome reference sequence, the ongoing identification of a dense set of human single nucleotide polymorphisms (SNPs) and the increasing understanding of how those variations are organized within major ...
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    Notes: [Auszug] The rapid accumulation of microarray data translates into a need for methods to effectively integrate data generated with different platforms. Here we introduce an approach, 2nd-order expression analysis, that addresses this challenge by first extracting expression patterns as meta-information from ...
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    Notes: [Auszug] Preparation of specific lineages at high purities from embryonic stem (ES) cells requires both selective culture conditions and markers to guide and monitor the differentiation. In this study, we distinguished definitive and visceral endoderm by using a mouse ES cell line that bears the gfp and ...
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    Notes: [Auszug] We have developed a class of binding proteins, called avimers, to overcome the limitations of antibodies and other immunoglobulin-based therapeutic proteins. Avimers are evolved from a large family of human extracellular receptor domains by in vitro exon shuffling and phage display, generating ...
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    Nature biotechnology 23 (2005), S. 1517-1526 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Dendrimers are branched, synthetic polymers with layered architectures that show promise in several biomedical applications. By regulating dendrimer synthesis, it is possible to precisely manipulate both their molecular weight and chemical composition, thereby allowing predictable tuning of their ...
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    Nature biotechnology 23 (2005), S. 1451-1451 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] There once was a time when the initial public offering (IPO) was without rival in the hearts and minds of biotech investors and entrepreneurs. The thought of a champagne cork-popping event like Genentech's fabulously successful IPO in 1980, which saw shares of the S. San Francisco firm leap from ...
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    Nature biotechnology 23 (2005), S. 1455-1456 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Among the most advanced cell therapies in clinical development, umbilical cord blood stem cell therapies used in the treatment of blood cancers are forging ahead, but it's an uphill struggle. The recent suspension of a phase 1/2 trial of a non-matched (allogeneic) cord blood therapy by Viacell ...
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    Nature biotechnology 23 (2005), S. 1029-1029 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Europe has a new plan to counter the worsening competitive position of its biopharmaceutical enterprises. But the scheme looks more tailored to meet the political aspirations of Brussels bureaucrats than to help the industry. The policy is nominally based on a report submitted by Boston-based ...
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    Nature biotechnology 23 (2005), S. 1457-1458 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The US government's recent raft of preemptive measures in favor of flu vaccine R&D and stockpiling in the wake of the October announcement of the creation of a new R&D funding agency to support biodefense research, funded by Project BioShield, may seem like a new window of opportunity for ...
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    Nature biotechnology 23 (2005), S. 1459-1460 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The giant European Investment Bank (EIB), based in Luxembourg, is looking to loan tens of millions of euros to biotech firms in late-stage product development. The move is aimed at boosting Europe's weak financing record, but experts are pessimistic about its prospects. The EIB initiative comes in ...
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    Nature biotechnology 23 (2005), S. 1465-1465 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotech venture creation in Russia can sometimes seem like roulette. Traditional models don't apply. Entrepreneurs must battle endemic bureaucracy, cronyism and corruption. And they must overcome a hostile business environment where government incentives are scarce, intellectual property (IP) ...
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    Nature biotechnology 23 (2005), S. 1466-1466 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Unlike last year's billion dollar approvals, Avastin (bevacizumab) and Erbitux (cetuximab), no biotech blockbusters were launched in 2005 and none appear to be on the horizon. Almost half of the biologics license applications pending at the US Food and Drug Administration (FDA) are for ...
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