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  • ASTROPHYSICS  (2,612)
  • Physics
  • 1990-1994  (2,614)
  • 1993  (1,389)
  • 1990  (1,225)
  • 1
    Electronic Resource
    Electronic Resource
    Calcium phosphates in pharmaceutical tableting (1993)
    Springer
    Pharmacy world & science 15 (1993), S. 105-115 
    Details
    ISSN: 1573-739X
    Keywords: Calcium phosphates ; Drug compounding ; Excipients ; Particle size ; Physics ; Powders ; Tablets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Ten commercially available calcium phosphates used for direct tableting were evaluated. The particle size distributions, powder properties, Sorption isotherms and pH values of aqueous slurries were compared. All samples showed good or at least sufficient flowability. Scanning electron micrographs illustrated the different kinds of manufacturing and gave hints on their expectable behaviour under compaction pressure. The sorption isotherms of identical chemical substances, which had been manufactured by different methods, differed strongly. This can be related to their specific surface areas. Most of the hydroxylapatites have large surface areas and can absorb up to more than 15% water at 93% relative humidity. Dibasic calcium phosphate dihydrate was non-hygroscopic and absorbed less than 1% water. With the exception of monobasic calcium phosphate monohydrate all calcium phosphates behaved quite neutral in water. Monobasic calcium phosphate monohydrate can be regarded as a solid acid. Although the calcium phosphates are usually stable substances, the role of crystal water in the case of dibasic calcium phosphate dihydrate and monobasic calcium phosphate monohydrate is problematic due to possible interactions with active ingredients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02113938
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    Paper (German National Licenses)
    Fulltext
  • 2
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    The meaning of hydrophobicity (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dill, K A -- New York, N.Y. -- Science. 1990 Oct 12;250(4978):297-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2218535" target="_blank"〉PubMed〈/a〉
    Keywords: Energy Transfer ; Physical Phenomena ; Physics ; *Protein Conformation ; Proteins/*chemistry ; Solutions
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 3
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    An ensemble pulsar time (1993)
    In:  CASI
    Details
    Publication Date: 2004-12-03
    Description: Millisecond pulsars are galactic objects that exhibit a very stable spinning period. Several tens of these celestial clocks have now been discovered, which opens the possibility that an average time scale may be deduced through a long-term stability algorithm. Such an ensemble average makes it possible to reduce the level of the instabilities originating from the pulsars or from other sources of noise, which are unknown but independent. The basis for such an algorithm is presented and applied to real pulsar data. It is shown that pulsar time could shortly become more stable than the present atomic time, for averaging times of a few years. Pulsar time can also be used as a flywheel to maintain the accuracy of atomic time in case of temporary failure of the primary standards, or to transfer the improved accuracy of future standards back to the present.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center, The 24th Annual Precise Time and Time Interval (PTTI) Applications and Planning Meeting; p 73-86
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    NASA TECHNICAL REPORTS
  • 4
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    Mass loading and velocity diffusion models for heavy pickup ions at comet Grigg-Skjellerup (1993)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: We compare model predictions of cometary water group ion densities and the solar wind slow down with measurements made by the Giotto Johnstone plasma analyzer implanted ion sensor at the encounter with comet Grigg-Skjellerup (G-S) on July 10, 1992. The observed slope of the ion density profile on approach to the comet is unexpectedly steep. Possible explanations for this are discussed. We present also a preliminary investigation of the quasilinear velocity-space diffusion of the implanted heavy ion population at G-S using a transport equation including souce, convection, adiabatic compression, and velocity diffusion terms. Resulting distributions are anisotropic, in agreement with observations. We consider theoretically the waves that may be generated by the diffusion process for the observed solar wind conditions. At initial ion injections, waves are generated at omega approximately Omega(sub i) the ion gyrofrequency, and lower frequencies are predicted for diffusion toward a bispherical shell.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 98; A12; p. 20,995-21,002
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    NASA TECHNICAL REPORTS
  • 5
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    Mirror modes and fast magnetoacoustic waves near the magnetic pileup boundary of comet P/Halley (1993)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: Large-amplitude ultralow-frequency wave structure observed on both sides of the magnetic pileup boundary of comet P/Halley during the flyby of the Giotto spacecraft have been analyzed using suprathermal electron density and magnetic field observations. Upstream of the boundary, electron density and magnetic field magnitude variations are anticorrelated, while in the pileup region these quantities are clearly correlated. Both in front of and behind the pileup boundary the observed waves are quasi-perpendicular wave structures as a minimum variance analysis shows. A detailed comparison of our observations in the prepileup region with theoretical and numerical results shows that the mirror mode mode waves may have been generated by a mirror instability driven by the pressure anisotropy of the ring-type distributions of the heavy (water group) pickup cometary ions.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 98; A12; p. 20,955-20,964
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    NASA TECHNICAL REPORTS
  • 6
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    SiS2 in circumstellar shells (1993)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: Solid state SiS2 is proposed as the material responsible for the recently discovered 21 micrometer emission feature that is observed in the carbon-rich circumstellar shells of certain protoplanetary nebulae. Sulfurized SiC, or SiS2 mantles on grains of either SiC or a:C-H are discussed as possible forms for which no spectroscopic laboratory observations yet exist. The identification with a relatively minor species and required special abundance ratios are consistent with the low incidence rate that the 21 micrometer feature presents in the population of carbon rich objects. It is also consistent with the lack of a good correlation between the 21 micrometer feature and the other solid-state spectroscopic features that have been observed in protoplanetaries that would be expected if the feature arose from molecules composed of H, C, N, and O. SiS2 condensate is consistent with the circumstellar shell temperature range, T(sub CS) approximately equal to or less than 150 K, at which the feature appears, and the available mass of SiS2, M(sub SiS2) approx. = 5 x 10(exp -6) solar mass, that is possible in the circumstellar shell.
    Keywords: ASTROPHYSICS
    Type: Astronomy and Astrophysics (ISSN 0004-6361); 278; 1; p. 226-230
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    NASA TECHNICAL REPORTS
  • 7
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    ROSAT PSPC spectra of six Seyfert 1 galaxies (1993)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: We present six ROSAT Position-Sensitive Proportional Counter (PSPC) observations of Seyfert 1 galaxies chosen to have low Galactic line-of-sight absorption (N(sub H) approx. = 10(exp 20)/sq cm). As expected, it is found that all of these sources possess significantly steeper spectra below approximately 1 keV, than that observed at higher X-ray energies. In addition we find evidence for soft X-ray spectral features, which are best parameterized as line emission at approximately 0.63 keV in NGC7469 and approximately 0.75 keV in ESO198-G24. We examine these results in the light of the accuracy of the PSPC spectral calibration. We suggest that Seyfert galaxies are a class of object whose spectra are similar to the diffuse X-ray background in the soft X-ray band. We suggest these data provide the first direct evidence that the sources which dominate the background differ as a function of energy.
    Keywords: ASTROPHYSICS
    Type: Advances in Space Research (ISSN 0273-1177); 13; 12; p. (12)387-(12)390
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    NASA TECHNICAL REPORTS
  • 8
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    Scientific results from COBE (1993)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: NASA's Cosmic Background Explorer (COBE) carries three scientific instruments to make precise measurements of the spectrum and anisotropy of the cosmic microwave background (CMB) radiation on angular scales greater than 7 deg and to conduct a search for a diffuse cosmic infrared background (CIB) radiation with 0.7 deg angular resolution. Data from the Far-Infrared Absolute Spectrophotometer (FIRAS) show that the spectrum of the CMB is that of a blackbody of temperature T = 2.73 +/- 0.06 K, with no deviation from a blackbody spectrum greater than 0.25% of the peak brightness. The first year of data from the Differential Microwave Radiometers (DMR) show statistically significant CMB anisotropy. The anisotropy is consistent with a scale invariant primordial density fluctuation spectrum. Infrared sky brightness measurements from the Diffuse Infrared Background Experiment (DIRBE) provide new conservative upper limits to the CIB. Extensive modeling of solar system and galactic infrared foregrounds is required for further improvement in the CIB limits.
    Keywords: ASTROPHYSICS
    Type: Advances in Space Research (ISSN 0273-1177); 13; 12; P. (12)409-(12)423
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    NASA TECHNICAL REPORTS
  • 9
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    The luminosity dependence of the phase-averaged X-ray spectrum of the transient 42 second pulsar EXO 2030+375 (1993)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: We report on the evolution in the X-ray spectrum of the transient X-ray pulsar EXO 2030+375 during part of an outburst in 1985 May-August. The overall continuum spectral shape is similar to that of other accreting pulsars and can be represented by a power-law spectrum modified at low energies by significant absorption and at high-energies either by an exponential cut-off or by the effects of cyclotron scattering. As the luminosity decreased by a factor of approximately 100, the X-ray spectrum became harder with the photon index decreasing from 1.83 +/- 0.01 to 1.29 +/- 0.01. In addition, the high-energy cutoff decreased from 20 to 10 keV during the same interval. If the cutoff is interpreted in terms of cyclotron resonance scattering, then this implies a magnetic field strength that decreased from 2.6 x 10(exp 12) G to 1.3 x 10(exp 12) G. This variation implies that the cutoff energy does not provide a reliable measure of the surface magnetic field strength in this system.
    Keywords: ASTROPHYSICS
    Type: Advances in Space Research (ISSN 0273-1177); 13; 12; p. (12)-355-(12)360
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    NASA TECHNICAL REPORTS
  • 10
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    HEAO-1 and BBXRT non-source X-ray observations (1993)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: A more appropriate title for this talk would have been 'Measurements of Large Scale Structure from X-ray Background Fluctuations'. While it has long been recognized that the X-ray Background (XRB) is primarily of a cosmological origin (with z less than a few), it has recently become apparent that surface brightness fluctuations in the surveys of the XRB can be used to trace the distribution of matter in much the same way as complete catalogs of individual objects. The distance which is probed is related to the angular resolution of the detector; for the HEAO-1 A2 experiment, which provides the best all-sky data base for the XRB in the 2-20 keV band, the effective depth is a few 100 Mpc.
    Keywords: ASTROPHYSICS
    Type: Advances in Space Research (ISSN 0273-1177); 13; 12; p. (12)231-(12)240
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    NASA TECHNICAL REPORTS
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