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  • Analytical Chemistry and Spectroscopy  (840)
  • Animals  (443)
  • Fisheries
  • 1980-1984  (1,284)
  • 1982  (1,284)
  • 1
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    Ontogeny of gastric acid secretion in the rat: evidence for multiple response systems (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: Gastric acid secretion has been thought to depend on histamine stimulation of the parietal cell. However, in the 2-week-old rat neither exogenous histamine nor the H-2 receptor agonist impromidine stimulates acid secretion, whereas pentagastrin and the cholinergic agent bethanechol are potent stimuli. At this age, the effect of pentagastrin in acid secretion is not blocked by the H-2 receptor antagonist cimetidine, nor is it potentiated by impromidine. These data suggest that, in the rat pup, the acid secretory response to pentagastrin and cholinergic agents occurs before the histamine-mediated system is functional and operates independently of the actions of histamine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ackerman, S H -- K1-MH00077/MH/NIMH NIH HHS/ -- R01-AM-18804/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):75-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6211765" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Bethanechol Compounds/pharmacology ; Gastric Juice/drug effects/*secretion ; Gastric Mucosa/growth & development ; Guanidines/pharmacology ; Histamine/pharmacology ; Imidazoles/pharmacology ; Impromidine ; Pentagastrin/pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Histamine H2/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Sensitivity to carcinogenesis in nude mice: skin tumors caused by transplacental exposure to ethylnitrosourea (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-12
    Description: Female athymic nude mice and their phenotypically normal littermates were exposed transplacentally to ethylnitrosourea. Skin tumors (papillomas and sebaceous adenomas) developed on the nude mice with an almost tenfold greater incidence than on their haired littermates. Skin tumors were also induced on nude mice but not haired controls by direct intraperitoneal treatment with ethylnitrosourea. These results indicate that nude mice have higher than normal susceptibility to carcinogenesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, L M -- Last-Barney, K -- Budinger, J M -- CA 08748/CA/NCI NIH HHS/ -- CA 22498/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):682-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134965" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoma/chemically induced ; Animals ; *Ethylnitrosourea ; Female ; *Maternal-Fetal Exchange ; Mice ; Mice, Nude/*physiology ; Neoplasms, Experimental/chemically induced ; *Nitrosourea Compounds ; Pregnancy ; Sebaceous Gland Neoplasms/chemically induced ; Skin Neoplasms/*chemically induced
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Primary changes of membrane currents during retention of associative learning (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-05
    Description: A single identified neuron was repeatedly isolated by axotomy from the central nervous system of the nudibranch mollusk Hermissenda crassicornis. An early voltage-dependent outward K+ current of this neuron was reduced and more rapidly inactivated for animals previously trained with paired but not randomized light and rotation. Since this current change can affect interneuron and motorneuron output via known synaptic pathways, it helps explain a long-lasting behavioral change that shows the defining features of vertebrate associative learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alkon, D L -- Lederhendler, I -- Shoukimas, J J -- New York, N.Y. -- Science. 1982 Feb 5;215(4533):693-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058334" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Association Learning/*physiology ; Central Nervous System/physiology ; Electric Conductivity ; Learning/*physiology ; Membrane Potentials ; Mollusca ; Neurons/*physiology ; Photoreceptor Cells/physiology ; Potassium/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Rapid and precise down regulation of fast axonal transport of transmitter in an identified neuron (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-26
    Description: Within 1 day after the removal of one branch of the bifurcated axon of an identified neuron in Aplysia, the cell body reduced its output of transmitter storage vesicles to adjust precisely for the decreased need. This adjustment terminated the initial consequence of the removal, the transport of an inappropriately large number of vesicles to the remaining synapses. The most likely cause of the reduction of transport of transmitter is the loss of information normally provided by the disconnected axon or synapses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aletta, J M -- Goldberg, D J -- GM 07182/GM/NIGMS NIH HHS/ -- NS 14711/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):913-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6182616" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aplysia/physiology ; *Axonal Transport ; Axons/*physiology ; Biological Transport ; Cytoplasmic Granules/metabolism ; Intracellular Membranes/metabolism ; Serotonin/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Prenatal and neonatal exposure to cimetidine results in gonadal and sexual dysfunction in adult males (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-29
    Description: Exposure of rats to cimetidine during intrauterine life and the immediate neonatal period results in hypoandrogenization in adult life with decreased weights of androgen-dependent tissues and decreased concentrations of testosterone. Moreover, sexual behavior patterns in adult life are disturbed as shown by a lack of sexual motivation and decreased performance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anand, S -- Van Thiel, D H -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):493-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123252" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*etiology ; Animals ; Animals, Suckling ; Cimetidine/metabolism/*toxicity ; Female ; Guanidines/*toxicity ; Male ; Pregnancy ; Pregnancy, Animal/drug effects ; Rats ; Sex Differentiation/*drug effects ; Sexual Behavior, Animal/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    24-hydroxylation of 25-hydroxyvitamin D3: is it required for embryonic development in chicks? (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-30
    Description: As shown previously, laying hens given 1,25-dihydroxyvitamin D3 as their sole source of vitamin D produce fertile eggs having normal shells, but only 35 to 55 percent of the embryos are normal. Giving these hens additional 25-hydroxyvitamin D3, 24,25-dihydroxyvitamin D3, or 24,24-difluoro-25-hydroxyvitamin D3 at 1.25 nanomoles per day resulted in 90 to 100 percent normal embryos, and hence, hatchability. Since 24,24-difluoro-25-hydroxyvitamin D3 cannot be 24-hydroxylated, 24-hydroxylation is not required for this function of 25-hydroxyvitamin D3.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ameenuddin, S -- Sunde, M -- DeLuca, H F -- Ikekawa, N -- Kobayashi, Y -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):451-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6979782" target="_blank"〉PubMed〈/a〉
    Keywords: 24,25-Dihydroxyvitamin D 3 ; Animal Feed ; Animals ; Calcifediol ; Calcitriol/analogs & derivatives/pharmacology ; Chick Embryo/*growth & development ; Chickens/metabolism ; Dihydroxycholecalciferols/pharmacology ; Female ; Hydroxycholecalciferols/*metabolism/pharmacology ; Hydroxylation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-10
    Description: Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernal, S D -- Lampidis, T J -- Summerhayes, I C -- Chen, L B -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1117-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146897" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinoma/*drug therapy ; Cell Line ; Cell Survival/drug effects ; Mice ; Mitochondria/metabolism ; Neoplasms, Experimental/drug therapy ; Rhodamine 123 ; Rhodamines/metabolism/therapeutic use ; Time Factors ; Urinary Bladder Neoplasms/drug therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Gene transfer between eukaryotes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benveniste, R E -- Todaro, G J -- New York, N.Y. -- Science. 1982 Sep 24;217(4566):1202.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112123" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Physiological Phenomena ; Eukaryotic Cells/*physiology ; Humans ; *Recombination, Genetic ; Retroviridae/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Relaxation of isolated gastric smooth muscle cells by vasoactive intestinal peptide (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-30
    Description: Vasoactive intestinal peptide caused a prompt, dose-dependent relaxation of isolated gastric smooth muscle cells of the guinea pig and a significant increase in intracellular adenosine 3',5'-monophosphate coincidentally with optimum relaxation. Relaxation was augmented by a threshold concentration of isobutyl methylxanthine. The direct relaxant effect of vasoactive intestinal peptide and the distribution of nerves containing this peptide to circular smooth muscle support the view that vasoactive intestinal peptide is the neuromuscular transmitter of enteric inhibitory nerves.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bitar, K N -- Makhlouf, G M -- AM-15564/AM/NIADDK NIH HHS/ -- AM-28300/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 30;216(4545):531-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6176025" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Methyl-3-isobutylxanthine/pharmacology ; Animals ; Cyclic AMP/physiology ; Gastrointestinal Hormones/*pharmacology ; Guinea Pigs ; In Vitro Techniques ; Muscle Contraction/*drug effects ; Muscle Relaxation/*drug effects ; Muscle, Smooth/*drug effects ; Neurotransmitter Agents/physiology ; Stomach/drug effects/*innervation ; Vasoactive Intestinal Peptide/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Reduced leucine-enkephalin--like immunoreactive substance in hamster basal ganglia after long-term ethanol exposure (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-25
    Description: Golden Syrian hamsters were placed individually in cages with three drinking bottles--one empty, one containing water, and the third containing water and ethanol. Control hamsters received water only. After 1 year the experimental hamsters showed a significantly lower concentration of leucine-enkephalin-like immunoreactive substance in the basal ganglia than the control hamsters. This finding indicates that the action of ethanol involves endogenous peptidyl opiates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blum, K -- Briggs, A H -- Elston, S F -- DeLallo, L -- Sheridan, P J -- Sar, M -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1425-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basal Ganglia/*drug effects ; Cricetinae ; Endorphins/*analysis ; Enkephalin, Leucine ; Enkephalins/*analysis/metabolism ; Ethanol/metabolism/*pharmacology ; Mesocricetus ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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