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  • Articles  (2,033)
  • 1960-1964  (2,033)
  • 1961  (2,033)
  • Mathematics  (2,033)
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  • 1960-1964  (2,033)
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  • 1
    Electronic Resource
    Electronic Resource
    An hypothesis of freese and the DNA-protein coding problem (1961)
    Springer
    Bulletin of mathematical biology 23 (1961), S. 305-318 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Freese’s Hypothesis states that a single specific alteration in the sequence of nucleotides of an information-bearing DNA molecule results in a specific mutational effect. Within the framework of the DNA-protein coding problem developed elsewhere, and assuming the quasi-ergodicity of the general coding process, it is shown that Freese’s Hypothesis allows us to derive expressions for the length of the smallest mutable DNA molecule and to obtain a bound for the maximal number of allelic molecules of fixed length. To illustrate these ideas, calculations are carried out on appropriate data from bacternophage and man, and the results are shown to differ by a factor of 10 (modulo the rather crude approximations used). It is further shown that, if ρ(N) and ϱ(N) are respectively the number of information-bearing words of lengthN in a given code and the number of words of lengthN, then the number lim ρ(N)/ϱ(N) depends sensitively on the parameter ∈ which specifiesN→∞ the given code. The implications of this result for the spontaneous aggregation of a sufficient number of information-bearing words to characterize an organism are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476743
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  • 2
    Electronic Resource
    Electronic Resource
    Post-and predoctoral fellowships in mathematical biology (1961)
    Springer
    Bulletin of mathematical biology 23 (1961), S. 319-319 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476744
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  • 3
    Electronic Resource
    Electronic Resource
    The perfect learner (1961)
    Springer
    Bulletin of mathematical biology 23 (1961), S. 321-335 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract As a “base line” of memorization performance, the behavior of a “perfect learner” is considered. He is characterized by a perfect memory and by the ability to choose the best search procedure in problems where the correct response from a given repertoire is to be found to each of several stimuli under the condition of “right” and “wroing” promptings by the experimenter. Expected learning curves are derived for the case of disjoint response repertoires associated with the stimuli under cyclic and random presentation of the stimuli and for the case of a single response repertoire (a one-to-one matching problem) under cyclic presentation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476490
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  • 4
    Electronic Resource
    Electronic Resource
    A method for the computation of aortic distensibility in the living human patient and its use for the determination of the aortic effects of aging, drugs, and exercise (1961)
    Springer
    Bulletin of mathematical biology 23 (1961), S. 337-353 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Detailed equations are given for the computation of aortic distensibility in the intact living human patient from measurements of systolic and diastolic arterial pressures, heart rate and cardiac output. From these equations, the aortic characteristics of a large series of normal men of different ages were computed. Comparing these results with measurements on excised aortas, a more pronounced trend toward increasing aortic stiffness with increasing age is evident in living than in dead aortas. Nor-epinephrine and exercise apparently cause the living aortas to constrict but to become more distensible. The same change occurs after 30 minutes of high spinal anesthesia. The ganglionic blocking agents hexamethonium, pentamethonium, and tetraethylammonium usually cause the living aorta to become stiffer, presumably due to dilatation. The aortas of patients with pulmonary disease usually react in different fashion to exercise or tetraethylammonium. The increased aortic distensibility that occurs with the hypertension induced by nor-epinephrine or exercise acts as a compensatory mechanism by decreasing systolic pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476491
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  • 5
    Electronic Resource
    Electronic Resource
    Dimensional analysis in mathematical biology I. General discussion (1961)
    Springer
    Bulletin of mathematical biology 23 (1961), S. 355-376 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Dimensional analysis is discussed from the viewpoint of its basic group properties and shown to be an algebraic Abelian group that is useful for analysis of physical measurements. The application of the method to various types of equations and the formulation of previously unclassified dimensions are discussed. Functional dimensional analysis is applied to the problems of cell size and biomass proliferation; future applications are also noted. A number of dimensionless terms have been formulated for cellular physiochemical phenomena. They apparently represent the first systematic study of biological dimensionless numbers recorded in the literature. A dimensionless proliferation law is suggested. A brief analysis of the physical dimensionality associated with information measures is carried out. Entropy and “information” are shown to be completely different in their dimensional meaning; other informational measures of possible interest in biology are proposed. The dimensional coding and computor analysis of biomathematical equations is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476492
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  • 6
    Electronic Resource
    Electronic Resource
    A minimal principle in biomechanics (1961)
    Springer
    Bulletin of mathematical biology 23 (1961), S. 377-391 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Expenditure of energy under several simultaneous forms (mechanical, chemical, etc.) is associated with all muscular activity. The energy is directly related to what is commonly called exertion or effort. This paper defines “muscular effort” quantitatively in terms of some of the elements of the dynamics of the human (and animal) body. It postulates that in all likelihood the individual will, consciously or otherwise, determine his motion (or his posture, if at rest) in such a manner as to reduce his total muscular effort to a minimum consistent with imposed conditions, or “constraints”. The principle, formulated in mathematical terms, is sufficient to ascribe to the moments at all body joints—a matter generally of free choice on the part of the individual—their most likely magnitudes. It therefore renders the equations of human (and animal) motion determinate within this context. The paper also describes briefly an iteration method for the solution of these equations, once they have been made determinate. A simple illustrative application of the principle is included.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476493
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  • 7
    Electronic Resource
    Electronic Resource
    On the role of chemical systems in the microphysical aspects of primary genetic mechanisms (1961)
    Springer
    Bulletin of mathematical biology 23 (1961), S. 393-403 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract It is pointed out that two fundamentally different views of primary genetic processes occur in the literature which are frequently confused. The first is a true communication-theoretic view, which regards the genetic apparatus as containing a real information-source and a transducer which converts that information to useful form. The second view is generally expressed as a template scheme based on the Watson-Crick model; it is shown that in this model there is actually no such thing as genetic information in a communication-theoretic sense. Both views are then discussed on the basis of microphysical principles developed in previous work of the author (Bull. Math. Biophysics,22, 227–255, 1960) in an attempt to find which approach is in closer accord with the biological facts. It is shown that, if the communication-theoretic view is correct, then the information-bearing object must act as a “catalyst,” but it is pointed out that the type of catalysis involved must be of a fundamentally different nature than that occurring in familiar enzyme-catalyzed reactions. On the basis of general considerations of irreversible changes in microphysical measuring systems, it is shown that any type of template must suffer a gradual and irreversible denaturation, which seems to make it unlikely that a template could play a primary role in fundamental genetic processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476494
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  • 8
    Electronic Resource
    Electronic Resource
    On imitative behavior. II. Time course of change from one behavior to another (1961)
    Springer
    Bulletin of mathematical biology 23 (1961), S. 405-411 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The theory developed in previous papers and based on distribution curves of definite form is generalized to any form of unimodel distributions. The time course of the change from one behavior to another is discussed and a general theorem about the time course is established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476495
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  • 9
    Electronic Resource
    Electronic Resource
    Abstract mathematical molecular biology (1961)
    Springer
    Bulletin of mathematical biology 23 (1961), S. 417-417 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476497
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  • 10
    Electronic Resource
    Electronic Resource
    Mathematical studies of the interaction of respiratory gases with whole blood II. CO2 absorption (1961)
    Springer
    Bulletin of mathematical biology 23 (1961), S. 1-14 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Some progress has been made on the problem of the interaction of respiratory gases with whole blood. A working mathematical model for the O2−CO2 interaction phenomena has been developed from mathematical studies of the data. The Edsall-Wyman (1958) model for CO2 absorption is improved upon in this paper by consolidating it with the O2 absorption model developed in paper I of this set (Bernard, S. R.,Bull. Math. Biophysics,22, 391–415, 1960). This improved model assumed the effect of O2 on CO2 absorption is mediated through the electrical charge possessed by the hemoglobin molecule,i.e., O2 molecules bound to hemoglobin displace protons from the hemoglobin thereby increasing the negative charge on the hemoglobin and at the same time increasing the acidity of the solution. The model is tested against the data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476569
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