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  • 1
    Keywords: Geoarchäologie ; Naturkatastrophe ; Archaeological geology ; Archaeology ; Archaeology and natural disasters ; Archäologie ; Archéologie et catastrophes naturelles ; Catastrophes (Geology) ; Catastrophes naturelles ; Earthquakes ; Effect of environment on ; Geschichte ; History ; Human beings ; Methodology ; Tremblements de terre ; Volcanoes ; Volcans
    Description / Table of Contents: Preface / Iain Stewart / Geological Society, London, Special Publications, 171, vii-ix, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.01 --- Creation and destruction of travertine monumental stone by earthquake faulting at Hierapolis, Turkey / P. L. Hancock, R. M. L. Chalmers, E. Altunel, Z. Çakir and A. Becher-Hancock / Geological Society, London, Special Publications, 171, 1-14, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.02 --- Uses of volcanic products in antiquity / D. R. Griffiths / Geological Society, London, Special Publications, 171, 15-23, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.03 --- The advent of archaeoseismology in the Mediterranean / R. E. Jones and S. C. Stiros / Geological Society, London, Special Publications, 171, 25-32, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.04 --- A critical reappraisal of the classical texts and archaeological evidence for earthquakes in the Atalanti region, central mainland Greece / Victoria Buck and Iain Stewart / Geological Society, London, Special Publications, 171, 33-44, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.05 --- Aims and methods in territorial archaeology: possible clues to a strong fourth-century AD earthquake in the Straits of Messina (southern Italy) / Emanuela Guidoboni, Anna Muggia and Gianluca Valensise / Geological Society, London, Special Publications, 171, 45-70, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.06 --- Santorini (Greece) before the Minoan eruption: a reconstruction of the ring-island, natural resources and clay deposits from the Akrotiri excavation / Walter L. Friedrich, Marit-Solveig Seidenkrantz and Ole Bjørslev Nielsen / Geological Society, London, Special Publications, 171, 71-80, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.07 --- The eruption of the Santorini volcano and its effects on Minoan Crete / Jan Driessen and Colin F. MacDonald / Geological Society, London, Special Publications, 171, 81-93, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.08 --- Late Minoan IB marine ware, the marine environment of the Aegean, and the Bronze Age eruption of the Thera volcano / Peter Bicknell / Geological Society, London, Special Publications, 171, 95-103, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.09 --- Ground-penetrating radar mapping of Minoan volcanic deposits and the Late Bronze Age palaeotopography, Thera, Greece / James K. Russell and Mark V. Stasiuk / Geological Society, London, Special Publications, 171, 105-121, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.10 --- Precursory phenomena and destructive events related to the Late Bronze Age Minoan (Thera, Greece) and AD 79 (Vesuvius, Italy) Plinian eruptions; inferences from the stratigraphy in the archaeological areas / Raffaello Cioni, Lucia Gurioli, Alessandro Sbrana and Georges Vougioukalakis / Geological Society, London, Special Publications, 171, 123-141, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.11 --- A geographical information system for the archaeological area of Pompeii / M. T. Pareschi, G. Stefani, A. Varone, L. Cavarra, F. Giannini and A. Meriggi / Geological Society, London, Special Publications, 171, 143-158, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.12 --- Apulian Bronze Age pottery as a long-distance indicator of the Avellino Pumice eruption (Vesuvius, Italy) / Raffaello Cioni, Sara Levi and Roberto Sulpizio / Geological Society, London, Special Publications, 171, 159-177, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.13 --- Human response to Etna volcano during the classical period / D. K. Chester, A. M. Duncan, J. E. Guest, P. A. Johnston and J. J. L. Smolenaars / Geological Society, London, Special Publications, 171, 179-188, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.14 --- The Johnston-Lavis collection: a unique record of Italian volcanism / W. L. Kirk, R. Siddall and S. Stead / Geological Society, London, Special Publications, 171, 189-194, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.15 --- The archaeology of a Plinian eruption of the Popocatépetl volcano / Patricia Plunket and Gabriela Uruñuela / Geological Society, London, Special Publications, 171, 195-203, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.16 --- Timing of the prehistoric eruption of Xitle Volcano and the abandonment of Cuicuilco Pyramid, Southern Basin of Mexico / Silvia Gonzalez, Alejandro Pastrana, Claus Siebe and Geoff Duller / Geological Society, London, Special Publications, 171, 205-224, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.17 --- Volcanic disasters and cultural discontinuities in Holocene time, in West New Britain, Papua New Guinea / Robin Torrence, Christina Pavlides, Peter Jackson and John Webb / Geological Society, London, Special Publications, 171, 225-244, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.18 --- Tephrochronology of the Brooks River Archaeological District, Katmai National Park and Preserve, Alaska: what can and cannot be done with tephra deposits / James R. Riehle, Don. E. Dumond, Charles E. Meyer and Jeanne M. Schaaf / Geological Society, London, Special Publications, 171, 245-266, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.19 --- Endemic stress, farming communities and the influence of Icelandic volcanic eruptions in the Scottish Highlands / R. A. Dodgshon, D. D. Gilbertson and J. P. Grattan / Geological Society, London, Special Publications, 171, 267-280, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.20 --- Comparison and cross-checking of historical, archaeological and geological evidence for the location and type of historical and sub-historical eruptions of multiple-vent oceanic island volcanoes / S. J. Day, J. C. Carracedo, H. Guillou, F. J. Pais Pais, E. Rodriguez Badiola, J. F. B. D. Fonseca and S. I. N. Heleno / Geological Society, London, Special Publications, 171, 281-306, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.21 --- ‘A fire spitting volcano in our dear Germany’: documentary evidence for a low-intensity volcanic eruption of the Gleichberg in 1783? / J. P. Grattan, D. D. Gilbertson and A. Dill / Geological Society, London, Special Publications, 171, 307-315, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.22 --- Volcanic soils: their nature and significance for archaeology / Peter James, David Chester and Angus Duncan / Geological Society, London, Special Publications, 171, 317-338, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.23 --- The use of volcaniclastic material in Roman hydraulic concretes: a brief review / Ruth Siddall / Geological Society, London, Special Publications, 171, 339-344, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.24 --- Olmec stone sculpture: selection criteria for basalt / Patrick Hunt / Geological Society, London, Special Publications, 171, 345-353, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.25 --- Seismic and volcanic hazards affecting the vulnerability of the Sana’a area of Yemen / Richard Hughes and Adrian Collings / Geological Society, London, Special Publications, 171, 355-372, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.26 --- Archaeological, geomorphological and geological evidence for a major earthquake at Sagalassos (SW Turkey) around the middle of the seventh century AD / Marc Waelkens, Manuel Sintubin, Philippe Muchez and Etienne Paulissen / Geological Society, London, Special Publications, 171, 373-383, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.27 --- Fault pattern of Nisyros Island volcano (Aegean Sea, Greece): structural, coastal and archaeological evidence / Stathis C. Stiros / Geological Society, London, Special Publications, 171, 385-397, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.28 --- The geological origins of the oracle at Delphi, Greece / J. Z. De Boer and J. R. Hale / Geological Society, London, Special Publications, 171, 399-412, 1 January 2000, https://doi.org/10.1144/GSL.SP.2000.171.01.29
    Pages: Online-Ressource (IX, 412 Seiten) , Illustrationen, Diagramme, Karten
    ISBN: 1862390622
    Language: English
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  • 2
    Keywords: Geologie ; Geomedizin ; Geschichte ; Gesundheitswesen ; Heilkunde ; Lithotherapie ; Medizin ; Naturheilkunde ; Therapie ; Umweltfaktor ; Umweltmedizin ; Balneology ; Earths, Medical and surgical uses of ; Environmentally induced diseases ; History ; Hydrotherapy ; Materia medica ; Medical geology ; Medicine ; Rocks ; Therapeutic use
    Description / Table of Contents: Geology as medicine and medics as geologists / Christopher J. Duffin / Geological Society, London, Special Publications, 375, 1-6, 23 August 2013, https://doi.org/10.1144/SP375.29 --- Lithotherapeutical research sources from antiquity to the mid-eighteenth century / Christopher J. Duffin / Geological Society, London, Special Publications, 375, 7-43, 4 September 2013, https://doi.org/10.1144/SP375.25 --- Cryptopalaeontology / Eladio Liñán, María Liñán and Joaquín Carrasco / Geological Society, London, Special Publications, 375, 45-64, 10 May 2013, https://doi.org/10.1144/SP375.14 --- The stomatological use of stones cited in the Kitab al-tasrif treatise (Abulcasis, 1000 CE) / Joaquín Carrasco and María Liñán / Geological Society, London, Special Publications, 375, 65-80, 11 December 2012, https://doi.org/10.1144/SP375.7 --- The gem electuary / Christopher J. Duffin / Geological Society, London, Special Publications, 375, 81-111, 17 December 2012, https://doi.org/10.1144/SP375.9 --- Medicinal terra sigillata: a historical, geographical and typological review / Arthur Macgregor / Geological Society, London, Special Publications, 375, 113-136, 15 November 2012, https://doi.org/10.1144/SP375.1 --- Materia medica in the seventeenth-century Paper Museum of Cassiano dal Pozzo / W. D. Ian Rolfe / Geological Society, London, Special Publications, 375, 137-156, 15 November 2012, https://doi.org/10.1144/SP375.3 --- History of the pharmaceutical use of pumice / Christopher J. Duffin / Geological Society, London, Special Publications, 375, 157-169, 17 December 2012, https://doi.org/10.1144/SP375.8 --- Pharmaceutical use of gold from antiquity to the seventeenth century / Renzo Console / Geological Society, London, Special Publications, 375, 171-191, 2 April 2013, https://doi.org/10.1144/SP375.12 --- Bezoar stones, magic, science and art / Maria Do Sameiro Barroso / Geological Society, London, Special Publications, 375, 193-207, 26 February 2013, https://doi.org/10.1144/SP375.11 --- Some early eighteenth century geological Materia Medica / Christopher J. Duffin / Geological Society, London, Special Publications, 375, 209-233, 2 April 2013, https://doi.org/10.1144/SP375.13 --- Religiosity and magic in some lithoiatric practices of European folk medicine / Massimo Aliverti / Geological Society, London, Special Publications, 375, 235-242, 23 August 2013, https://doi.org/10.1144/SP375.27 --- Britain’s spa heritage: a hydrogeological appraisal / John D. Mather / Geological Society, London, Special Publications, 375, 243-260, 2 April 2013, https://doi.org/10.1144/SP375.16 --- Groundwater – Medicine by the Glassful? / N. S. Robins and P. L. Smedley / Geological Society, London, Special Publications, 375, 261-267, 2 April 2013, https://doi.org/10.1144/SP375.17 --- Sunday Stone: an enduring metaphor of mining diseases and underground mining conditions / John H. Pearn and Christopher Gardner-Thorpe / Geological Society, London, Special Publications, 375, 269-278, 11 July 2013, https://doi.org/10.1144/SP375.22 --- The influence of geology in the development of public health / Beverly P. Bergman / Geological Society, London, Special Publications, 375, 279-287, 15 November 2012, https://doi.org/10.1144/SP375.6 --- From flesh to fossils – Nicolaus Steno’s anatomy of the Earth / Jakob Bek-Thomsen / Geological Society, London, Special Publications, 375, 289-305, 2 April 2013, https://doi.org/10.1144/SP375.15 --- Diagnosing fossilization in the Nordic Renaissance: an investigation into the correspondence of Ole Worm (1588–1654) / Ella Hoch / Geological Society, London, Special Publications, 375, 307-327, 17 September 2013, https://doi.org/10.1144/SP375.26 --- Education forms the tender mind / Christopher Gardner-Thorpe / Geological Society, London, Special Publications, 375, 329-337, 23 August 2013, https://doi.org/10.1144/SP375.28 --- James Parkinson’s ‘system of successive creations’ / Cherry Lewis / Geological Society, London, Special Publications, 375, 339-348, 15 May 2013, https://doi.org/10.1144/SP375.18 --- From obstetrics to oryctology: inside the mind of William Hunter (1718–1783) / J. J. Liston / Geological Society, London, Special Publications, 375, 349-373, 15 May 2013, https://doi.org/10.1144/SP375.21 --- John Jeremiah Bigsby, MD: British Army physician and pioneer North American geologist / Leonard G. Wilson / Geological Society, London, Special Publications, 375, 375-394, 15 May 2013, https://doi.org/10.1144/SP375.20 --- Five eighteenth-century medical polymaths / Gillian C. Hull / Geological Society, London, Special Publications, 375, 395-407, 15 November 2012, https://doi.org/10.1144/SP375.5 --- John Whitaker Hulke, surgeon and palaeontologist / Simon Wills / Geological Society, London, Special Publications, 375, 409-427, 22 February 2013, https://doi.org/10.1144/SP375.10 --- Dr Arthur Conan Doyle’s contribution to the popularity of pterodactyls / David M. Martill and Tony Pointon / Geological Society, London, Special Publications, 375, 429-443, 15 May 2013, https://doi.org/10.1144/SP375.19 --- Physicians and their contribution to the early history of earth sciences in Austria / Daniela Claudia Angetter, Bernhard Hubmann and Johannes Seidl / Geological Society, London, Special Publications, 375, 445-454, 15 November 2012, https://doi.org/10.1144/SP375.4 --- Medical geologists during the Heroic Age of Antarctic exploration / Henry Guly / Geological Society, London, Special Publications, 375, 455-462, 15 November 2012, https://doi.org/10.1144/SP375.2 --- Vomiting stones: mental illness and forensic medicine in 18th century Italy / Alessandro Porro, Carlo Cristini, Bruno Falconi, Antonia Francesca Franchini and Lorenzo Lorusso / Geological Society, London, Special Publications, 375, 463-468, 4 July 2013, https://doi.org/10.1144/SP375.23 --- Geology, conservation and dissolution of corpses by Paolo Gorini (1813–1881) / Lorenzo Lorusso, Bruno Falconi, Francesca Antonia Franchini and Alessandro Porro / Geological Society, London, Special Publications, 375, 469-474, 9 July 2013, https://doi.org/10.1144/SP375.24
    Pages: Online-Ressource (VI, 490 Seiten) , Illustrationen, Diagramme, Karten
    ISBN: 9781862396432
    Language: English
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  • 3
    Keywords: Hutton, James ; Geology ; Geology - Great Britain - History - 18th century ; Historical geology ; History ; Influence on geology ; Theory of the earth
    Description / Table of Contents: Donald B. Mcintyre: James Hutton’s Edinburgh: a précis / Geological Society, London, Special Publications, 150:1-12, doi:10.1144/GSL.SP.1999.150.01.01 --- Don L. Anderson: A theory of the Earth: Hutton and Humpty Dumpty and Holmes / Geological Society, London, Special Publications, 150:13-35, doi:10.1144/GSL.SP.1999.150.01.02 --- Peter J. Wyllie: Hot little crucibles are pressured to reveal and calibrate igneous processes / Geological Society, London, Special Publications, 150:37-57, doi:10.1144/GSL.SP.1999.150.01.03 --- Werner Schreyer: High-pressure experiments and the varying depths of rock metamorphism / Geological Society, London, Special Publications, 150:59-74, doi:10.1144/GSL.SP.1999.150.01.04 --- Andrew J. Watson: Coevolution of the Earth’s environment and life: Goldilocks, Gaia and the anthropic principle / Geological Society, London, Special Publications, 150:75-88, doi:10.1144/GSL.SP.1999.150.01.05 --- Ursula B. Marvin: Impacts from space: the implications for uniformitarian geology / Geological Society, London, Special Publications, 150:89-117, doi:10.1144/GSL.SP.1999.150.01.06 --- Ian W. D. Dalziel: Vestiges of a beginning and the prospect of an end / Geological Society, London, Special Publications, 150:119-155, doi:10.1144/GSL.SP.1999.150.01.07 --- S. K. Monro and A. J. Crosbie: The Dynamic Earth project and the next millennium / Geological Society, London, Special Publications, 150:157-167, doi:10.1144/GSL.SP.1999.150.01.08 --- Robert H. Dott, Jr: Closing remarks for the Hutton bicentenary, Edinburgh / Geological Society, London, Special Publications, 150:169-173, doi:10.1144/GSL.SP.1999.150.01.09 --- Dennis R. Dean: Hutton Scholarship, 1992–1997 / Geological Society, London, Special Publications, 150:175-179, doi:10.1144/GSL.SP.1999.150.01.10
    Pages: Online-Ressource (VIII, 184 Seiten) , Illustrationen, Diagramme, Karten
    ISBN: 1862390266
    Language: English
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  • 4
    Keywords: Physics ; History ; Nuclear physics ; Heavy ions ; Hadrons ; Particle acceleration ; Physics ; Nuclear Physics, Heavy Ions, Hadrons ; History and Philosophical Foundations of Physics ; Particle Acceleration and Detection, Beam Physics ; History of Science
    Description / Table of Contents: Part I Reminiscences: Rolf Hagedorn and Relativistic Heavy Ion Research.-- Part II The Hagedorn Temperature --- Part III Melting Hadrons, Boiling Quarks Heavy Ion Path to Quark-Gluon Plasma --- Acronyms
    Pages: Online-Ressource (XVI, 441 pages)
    ISBN: 9783319175454
    Language: English
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  • 5
    Keywords: Geologie ; Geomedizin ; Geschichte ; Gesundheitswesen ; Heilkunde ; Lithotherapie ; Medizin ; Naturheilkunde ; Therapie ; Umweltfaktor ; Umweltmedizin ; Balneology ; Earths, Medical and surgical uses of ; Environmentally induced diseases ; History ; Hydrotherapy ; Materia medica ; Medical geology ; Medicine ; Rocks ; Therapeutic use
    Description / Table of Contents: Article --- Men, methods and materials: exploring the historical connections between geology and medicine / Christopher J. Duffin / Geological Society, London, Special Publications, 452, 1-8, 26 April 2017, https://doi.org/10.1144/SP452.19 --- Men and methods --- Earth science as a philosophical background to medicine: an essay based on the autobiography of Dr Otto Sperling (1602–81) / Ella Hoch / Geological Society, London, Special Publications, 452, 9-33, 10 April 2017, https://doi.org/10.1144/SP452.18 --- Nathaniel Hodges and the purging wells of Shooter's Hill / John D. Mather and Christopher J. Duffin / Geological Society, London, Special Publications, 452, 35-45, 19 December 2016, https://doi.org/10.1144/SP452.4 --- Water and the city of Milan at the end of the nineteenth century / Alessandro Porro, Antonia Francesca Franchini, Bruno Falconi, Paolo Maria Galimberti and Lorenzo Lorusso / Geological Society, London, Special Publications, 452, 47-54, 22 December 2016, https://doi.org/10.1144/SP452.9 --- Italian physicians’ contribution to geosciences / Marco Pantaloni, Fabiana Console, Lorenzo Lorusso, Fabio Massimo Petti, Antonia Francesca Franchini, Alessandro Porro and Marco Romano / Geological Society, London, Special Publications, 452, 55-75, 22 March 2017, https://doi.org/10.1144/SP452.17 --- The obstetrician, the surgeon and the premature birth of the world's first dinosaur: William Hunter and James Parkinson / J. J. Liston and L. Alcalá / Geological Society, London, Special Publications, 452, 77-101, 18 January 2017, https://doi.org/10.1144/SP452.7 --- Pau Estorch Siqués (1805–71) and his ‘magnes venenorum’ / F. Sabaté Casellas and B. Torres Gallardo / Geological Society, London, Special Publications, 452, 103-106, 2 February 2017, https://doi.org/10.1144/SP452.12 --- Duncan and Son: changing professional boundaries in the geological and medical sciences in the nineteenth and twentieth centuries / Tim Carter and Anne Spurgeon / Geological Society, London, Special Publications, 452, 107-113, 19 December 2016, https://doi.org/10.1144/SP452.8 --- From giant birds to X-rays: Victor Lemoine (1837–97), physician and palaeontologist / Eric Buffetaut / Geological Society, London, Special Publications, 452, 115-131, 19 December 2016, https://doi.org/10.1144/SP452.3 --- Materials --- Geotherapeutics: the medicinal use of earths, minerals and metals from antiquity to the twenty-first century / Spyros Retsas / Geological Society, London, Special Publications, 452, 133-139, 20 December 2016, https://doi.org/10.1144/SP452.5 --- Archaeological medicinal earths as antibacterial agents: the case of the Basel Lemnian sphragides / E. Photos-Jones, C. Edwards, F. Häner, L. Lawton, C. Keane, A. Leanord and V. Perdikatsis / Geological Society, London, Special Publications, 452, 141-153, 2 February 2017, https://doi.org/10.1144/SP452.6 --- Alectorius: a parasympathomimetic stone? / Joaquin Carrasco and Christopher J. Duffin / Geological Society, London, Special Publications, 452, 155-162, 21 February 2017, https://doi.org/10.1144/SP452.15 --- ‘Serpent stones’: myth and medical application / Rachael Pymm / Geological Society, London, Special Publications, 452, 163-180, 19 December 2016, https://doi.org/10.1144/SP452.1 --- ‘A charm to impose on the vulgar’: the medicinal and magical applications of the snakestone bead within the British Isles / Rachael Pymm / Geological Society, London, Special Publications, 452, 181-194, 2 February 2017, https://doi.org/10.1144/SP452.13 --- The name is the message: eagle-stones and materia medica in South America / Irina Podgorny / Geological Society, London, Special Publications, 452, 195-210, 27 February 2017, https://doi.org/10.1144/SP452.14 --- ‘Fish’, fossil and fake: medicinal unicorn horn / Christopher J. Duffin / Geological Society, London, Special Publications, 452, 211-259, 1 March 2017, https://doi.org/10.1144/SP452.16 --- ‘Not used to be worn as a Jewel’: The wearing of precious stones in early modern England – ornaments or medicine? / Tom Blaen / Geological Society, London, Special Publications, 452, 261-265, 22 December 2016, https://doi.org/10.1144/SP452.10 --- Coral in Petrus Hispanus’ ‘Treasury of the Poor’ / Maria Do Sameiro Barroso / Geological Society, London, Special Publications, 452, 267-282, 22 December 2016, https://doi.org/10.1144/SP452.11 --- Lead, isotopes and ice: a deadly legacy revealed / Beverly P. Bergman / Geological Society, London, Special Publications, 452, 283-291, 19 December 2016, https://doi.org/10.1144/SP452.2
    Pages: Online-Ressource (298 Seiten) , Illustrationen, Diagramme, Karten
    ISBN: 9781786202833
    Language: English
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  • 6
    Keywords: Geography ; History ; Education ; Economic aspects ; Human geography ; Geography ; Historical Geography ; Human Geography ; Education Economics ; History of Science
    Description / Table of Contents: Chapter 1: Geographies of the University. An Introduction (Peter Meusburger) --- Part 1: Historical Perspectives --- Chapter 2: The Repertorium Academicum Germanicum (RAG) and the Geography of German Universities and Academics (1350–1550) (Rainer C. Schwinges) --- Chapter 3: Scientific and Cultural Relations between Heidelberg University and Hungary over Five Centuries (Peter Meusburger) --- Chapter 4: Catchment Areas and Killing Fields: Towards an Academic Geography of the Thirty Years' War (Howard Hotson) --- Chapter 5: A Political Geography of University Foundation: The Case of the Danish Monarchy (Hanne Kirstine Adriansen) --- Chapter 6: ‘A Small Town of Character’: Locating a New Scottish University, 1963 - 1965 (Michael Heffernan) --- Part II: Spaces and Governance of Knowledge, Research and Education --- Chapter 7: Knowledge Environments at Universities. Some Theoretical and Methodological Considerations (Peter Meusburger) --- Chapter 8: Quality Cultures in Higher Education Institutions. Development of the Quality Culture Inventory (Christine Sattler) --- Chapter 9: Agnotology: Ignorance and Absence, or Towards a Sociology of Things that Aren’t There (Jennifer L. Croissant) --- part III: Universities and Regional Economies --- Chapter 10: The entrepreneurial university wave: shaping a triple helix for sustainable innovation (Henry Etzkowitz) --- Chapter 11: The Economic Impact of the Universities in the State of Baden-Württemberg (Johannes Glückler) --- Chapter 12: African Universities as Employers of Returning Graduates from Germany. The Example of Ghana and Cameroon (Julia Boger) --- Part IV: Localization, Globalization and Regional Integration of Universities --- Chapter 13: The University in its Place: Thinking in and Beyond Globalization (Allan Cochrane ) --- Chapter 14: The University Unbound: How Roots and Routes Intersect (Jane Kenway) --- Chapter 15: International Education Hubs (Jane Knight) --- Chapter 16: The Nonmetropolitan University’s Regional Engagement in the African Context: The Case of Cameroon (Eike W. Schamp) --- Chapter 17: China’s Southern Borderlands and ASEAN Higher education. A Cartography of Connectivity (Anthony Welch) --- Part V: Universities and the City --- Chapter 18: The Civic University and the City (John Goddard) --- Chapter 19: City and University – Notes of an Architect On an Intriguing Spatial Relationship (Helmut Bott) --- Chapter 20: Campus-city Relations: Past, Present and Future (Alexandra Den Heijer) --- Chapter 21: Coevolution of Town and Gown: The Heidelberg International Building Exhibition in Search of a Knowledge-based Urbanism for the Twenty-first Century (Carl Zillich) --- The Klaus Tschira Foundation --- Index
    Pages: Online-Ressource (XIV, 676 pages) , 155 illustrations, 99 illustrations in color
    ISBN: 9783319755939
    Language: English
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  • 7
    Keywords: Physics ; History ; Nuclear physics ; Heavy ions ; Hadrons ; Particle acceleration ; Physics ; Nuclear Physics, Heavy Ions, Hadrons ; History and Philosophical Foundations of Physics ; Particle Acceleration and Detection, Beam Physics ; History of Science
    Description / Table of Contents: Part I Reminiscences: Rolf Hagedorn and Relativistic Heavy Ion Research.-- Part II The Hagedorn Temperature --- Part III Melting Hadrons, Boiling Quarks Heavy Ion Path to Quark-Gluon Plasma --- Acronyms
    Pages: Online-Ressource (XVI, 441 pages)
    ISBN: 9783319175454
    Language: English
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  • 8
    Unknown
    Clayton, Victoria (Australia) : Monash University Publishing
    Keywords: History ; Antipodes ; ancient geography ; southern exploration ; geographical exploration ; exploration by sea ; discoveries in geography ; discovery of Australia ; cartography ; historical cartography ; imaginative cartography ; southern continent
    Description / Table of Contents: This book is a new history of an ancient geography. It reassesses the evidence for why Europeans believed a massive southern continent existed, and why they advocated for its discovery. When ships were equal to ambitions, explorers set out to find and claim Terra Australis. Antipodes charts these voyages—voyages both through the imagination and across the High Seas—in pursuit of the mythical Terra Australis. In doing so, the question is asked: how could so many fail to see the realities they encountered? And how is it a mythical land held the gaze of an era famed for breaking free the shackles of superstition? That Terra Australis did not exist didn’t stop explorers pursuing the continent, unwilling to abandon the promise of such a rich and magnificent land till it was stripped of every ounce of value it had ever promised. In the process, the southern continent—an imaginary land—became one of the shaping forces of early modern history. Includes 48 pages of b&w and colour images.
    Pages: Online-Ressource (XVIII, 264 Seiten) , Illustrationen, Diagramme
    ISBN: 9781925377330
    Language: English
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  • 9
    Publication Date: 2024-04-02
    Description: As part of an effort to assist Chile in developing a strategic program to foster the development of the health information technology (health IT) sector over the next five to ten years, this report assesses the current state of health IT adoption and implementation in Chile, as well as the challenges and opportunities facing the sector over the coming years.
    Keywords: Health Sciences ; History ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBQ Medicolegal issues
    Language: English
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  • 10
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    University Press of Colorado | Utah State University Press
    Publication Date: 2024-04-02
    Description: The central issue Bush finds in these works is how their authors have dealt with the authority of Mormon Church leaders. As she puts it in her preface, "I use the phrase 'faithful transgression' to describe moments in the texts when each writer, explicitly or implicitly, commits herself in writing to trust her own ideas and authority over official religious authority while also conceiving of and depicting herself to be a 'faithful' member of the Church." Bush recognizes her book as her own act of faithful transgression. Writing it involved wrestling, she states, "with my own deeply ingrained religious beliefs and my equally compelling education in feminist theories that mean to liberate and empower women." Faithful Transgressions examines a remarkable group of authors and their highly readable and entertaining books. In producing the first significant book-length study of Mormon women's autobiographical writing, Bush rides a wave of memoir publishing and academic interest in autobiography and other life narratives. As she elucidates these works in relation to the religious tradition that played a major role in shaping them, she not only positions them in relation to feminist theory and current work on women's life writings but ties them to the long literary tradition of spiritual autobiography.
    Keywords: History ; Religion ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity::QRMB Christian Churches, denominations, groups
    Language: English
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  • 11
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    Ohio University Press | Ohio University Press
    Publication Date: 2024-03-24
    Description: This intellectual history of Standard Swahili explores the long-term, intertwined processes of standard making and community creation in the historical, political, and cultural contexts of East Africa and beyond. Morgan J. Robinson argues that the portability of Standard Swahili has contributed to its wide use not only across the African continent but also around the globe. The book pivots on the question of whether standardized versions of African languages have empowered or oppressed. It is inevitable that the selection and promotion of one version of a language as standard—a move typically associated with missionaries and colonial regimes—negatively affected those whose language was suddenly deemed nonstandard. Before reconciling the consequences of codification, however, Robinson argues that one must seek to understand the process itself. The history of Standard Swahili demonstrates how events, people, and ideas move rapidly and sometimes surprisingly between linguistic, political, social, or temporal categories.Robinson conducted her research in Zanzibar, mainland Tanzania, and the United Kingdom. Organized around periods of conversation, translation, and codification from 1864 to 1964, the book focuses on the intellectual history of Swahili’s standardization. The story begins in mid-nineteenth-century Zanzibar, home of missionaries, formerly enslaved students, and a printing press, and concludes on the mainland in the mid-twentieth century, as nationalist movements added Standard Swahili to their anticolonial and nation-building toolkits. This outcome was not predetermined, however, and Robinson offers a new context for the strong emotions that the language continues to evoke in East Africa. The history of Standard Swahili is not one story, but rather the connected stories of multiple communities contributing to the production of knowledge. The book reflects this multiplicity by including the narratives of colonial officials and anticolonial nationalists; East African clerks, students, newspaper editors, editorialists, and their readers; and library patrons, academic linguists, formerly enslaved children, and missionary preachers. The book reconstructs these stories on their own terms and reintegrates them into a new composite that demonstrates the central place of language in the history of East Africa and beyond.
    Keywords: Foreign Language Study ; Swahili ; History ; Social History ; Social Science ; Anthropology ; Cultural & Social ; thema EDItEUR::C Language and Linguistics::CJ Language teaching and learning ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology
    Language: English
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  • 12
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 13
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 14
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    Duke University Press
    Publication Date: 2024-04-02
    Description: In 'An Aqueous Territory' Ernesto Bassi traces the configuration of a geographic space he calls the transimperial Greater Caribbean between 1760 and 1860. Focusing on the Caribbean coast of New Granada (present-day Colombia), Bassi shows that the region's residents did not live their lives bounded by geopolitical borders. Rather, the cross-border activities of sailors, traders, revolutionaries, indigenous peoples, and others reflected their perceptions of the Caribbean as a transimperial space where trade, information, and people circulated, both conforming to and in defiance of imperial regulations. Bassi demonstrates that the islands, continental coasts, and open waters of the transimperial Greater Caribbean constituted a space that was simultaneously Spanish, British, French, Dutch, Danish, Anglo-American, African, and indigenous.
    Keywords: History ; Colombia ; Haiti ; Jamaica ; Riohacha ; Santa Marta ; Spain ; United States ; Wayuu people ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
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  • 15
    Publication Date: 2024-04-04
    Description: This report shares an overview of the budget of the U.S. Department of Veterans Affairs (VA) and focuses particularly on health care spending and the Veterans Health Administration (VHA), including makeup of the veteran population, available health coverage, patterns of use, and potential areas of improvement.
    Keywords: History ; Health Sciences ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services
    Language: English
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  • 16
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    Böhlau
    Publication Date: 2024-04-04
    Description: The attraction of crises keeps going an entire sector of the media industry. Authors, painters, photographers and directors tell fascinating stories about the decline of empires and democracies as much as earthquakes and infectious diseases. Hereby, catastrophe and collapse evolve as a complex construct of experience, interpretation and emotion. The resulting narrative combines analyses of facts about the collapse with a retrospect evaluation, update and confirmation of these facts in the cultural memory of a given society. The random occurrence becomes a memorable event. The contributors of this volume have taken a narratological approach in examining collapse, disaster, catastrophe and how these in turn manifest themselves across different types of media.
    Keywords: History ; Social History ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: English
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  • 17
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    Duke University Press
    Publication Date: 2022-05-02
    Description: In CHINESE SURPLUS Ari Heinrich dissects the figure of the medically or artistically commodified body in Chinese culture and popular science. Providing a history of how bodies have been thought and seen to mirror the nation, Heinrich charts the trajectory from an imperial idea of the body as a machine with interchangeable parts to current representations in which the parts are worth more than the whole and may be harvested at will--what he calls a diasporic form of the body. In seeing the body this way Heinrich makes clear his case for a new method he calls biopolitical aesthetics, one that uses the tools of literary and visual culture analysis to restore agency to aesthetics in the production of meaning in life during contemporary biopolitical times.
    Keywords: History ; Aesthetics ; China ; Hong Kong
    Language: English
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  • 18
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 19
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    University of Michigan Press | University of Michigan Press
    Publication Date: 2024-04-02
    Description: "Printing and Prophecy: Prognostication and Media Change 1450-1550 examines prognostic traditions and late medieval prophetic texts in the first century of printing and their effect on the new medium of print. The many prophetic and prognostic works that followed Europe's earliest known printed book—not the Gutenberg Bible, but the Sibyl's Prophecy, printed by Gutenberg two years earlier and known today only from a single page—over the next century were perennial best sellers for many printers, and they provide the modern observer with a unique way to study the history and inner workings of the print medium. The very popularity of these works, often published as affordable booklets, raised fears of social unrest. Printers therefore had to meet customer demand while at the same time channeling readers' reactions along approved paths. Authors were packaged—and packaged themselves—in word and image to respond to the tension, while leading figures of early modern culture such as Paracelsus, Martin Luther, and Sebastian Brant used printed prophecies for their own purposes in a rapidly changing society. Based on a wide reading of many sources, Printing and Prophecy contributes to the study of early modern literature, including how print changed the relationship among authors, readers, and texts. The prophetic and astrological texts the book examines document changes in early modern society that are particularly relevant to German studies and are key texts for understanding the development of science, religion, and popular culture in the early modern period. By combining the methods of cultural studies and book history, this volume brings a new perspective to the study of Gutenberg and later printers."
    Keywords: History ; Astrology ; Latin ; Lichtenberger ; Practica (astrology) ; Prophecy ; Woodcut ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 20
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 21
    Publication Date: 2024-03-29
    Description: This study provides a quantitative and qualitative status report on the implementation of school-based management (SBM) in Indonesia, identifies factors associated with the successful practices of SBM, and assesses SBM effects on student achievement eight years after inception. They found that the implementation so far has produced limited success and provide recommendations to strengthen the nation’s SBM practices.
    Keywords: Education ; History ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education::JNKC Curriculum planning & development ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education::JNKD Examinations & assessment ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs::JNSV Teaching of students with English as a second language (TESOL) ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJF Asian history ; thema EDItEUR::J Society and Social Sciences::JN Education::JND Educational systems and structures::JNDG Curriculum planning and development ; thema EDItEUR::J Society and Social Sciences::JN Education::JND Educational systems and structures::JNDH Education: examinations and assessment ; thema EDItEUR::J Society and Social Sciences::JN Education::JNU Teaching of a specific subject ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history
    Language: English
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  • 22
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 23
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders;celiac disease;gluten intolerance ; bic Book Industry Communication::M Medicine
    Language: English
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  • 24
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    Fordham University Press
    Publication Date: 2023-10-05
    Description: Why have Americans expressed concern about immigration at some times but not at others? In pursuit of an answer, this book examines America's first nativist movement, which responded to the rapid influx of 4.2 million immigrants between 1840 and 1860 and culminated in the dramatic rise of the National American Party. As previous studies have focused on the coasts, historians have not yet completely explained why westerners joined the ranks of the National American, or "Know Nothing," Party or why the nation's bloodiest anti-immigrant riots erupted in western cities-namely Chicago, Cincinnati, Louisville, and St. Louis. In focusing on the antebellum West, Inventing America's First Immigration Crisis illuminates the cultural, economic, and political issues that originally motivated American nativism and explains how it ultimately shaped the political relationship between church and state. In six detailed chapters, Ritter explains how unprecedented immigration from Europe and rapid westward expansion reignited fears of Catholicism as a corrosive force. He presents new research on the inner sanctums of the secretive Order of Know-Nothings and provides original data on immigration, crime, and poverty in the urban West. Ritter argues that the country's first bout of political nativism actually renewed Americans' commitment to church-state separation. Native-born Americans compelled Catholics and immigrants, who might have otherwise shared an affinity for monarchism, to accept American-style democracy. Catholics and immigrants forced Americans to adopt a more inclusive definition of religious freedom. This study offers valuable insight into the history of nativism in U.S. politics and sheds light on present-day concerns about immigration, particularly the role of anti-Islamic appeals in recent elections.
    Keywords: Sociology ; History ; American Studies ; Religion ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFJ Social discrimination & inequality ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJK History of the Americas ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRC Christianity::HRCC Christian Churches & denominations::HRCC7 Roman Catholicism, Roman Catholic Church
    Language: English
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  • 25
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 26
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-04
    Description: For the first time, this book examines the comparative impact of the Obama administration on the NATO and defense policies of European allies. Germany, Poland and Turkey serve as case studies to evaluate American policies vis-à-vis NATO Europe. All three are representative for the Alliance in various ways. Thus, the results of this book offer an outlook for NATO Europe and the Alliance as a whole. Despite the fact that all three countries are highly dependent on American security guarantees in theory and practice, the results of this study reveal different national responses. Indeed, the book demonstrates multi-, bi-, and unilateralization attempts in reaction to US engagement in and vis-à-vis NATO Europe. Hence, a better understanding of current developments within the Alliance as well as the basis for the future debate about the transatlantic organisation are provided. Aylin Matlé works for the Konrad-Adenauer-Stiftung e.V.; most recently, she worked for the foundation's Israel office in Jerusalem. Previously, Aylin Matlé was a research associate at the chair of international relations and European politics at the Martin-Luther-Universität Halle-Wittenberg.
    Keywords: History ; Military ; Political Science ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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  • 27
    Publication Date: 2024-03-29
    Description: The U.S. armed forces must be prepared to deploy to a wide range of locations and confront adversaries that span the threat spectrum. This report reviews selected findings from a study of Army and joint anti-access and area denial challenges and proposes a joint approach to countering these threats in future operations.
    Keywords: History ; Technology ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWK Military and defence strategy ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTM Military engineering
    Language: English
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  • 28
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 29
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    Boydell & Brewer Ltd
    Publication Date: 2024-04-06
    Description: Ukrainian dissident Myroslav Marynovych recounts his involvement in the Brezhnev-era human rights movement in the Soviet Union and his resulting years as a political prisoner in Siberia and in internal exile. This memoir by a prominent Ukrainian dissident, now in English translation, offers a unique account that spans the entire postwar period, from the authors childhood in newly Soviet western Ukraine and coming of age within the Communist system to the collapse of the Soviet Union, concluding with his reflections on culpability and justice in the post-Soviet context. Marynovys description of the varied landscape of Ukrainian dissent in the 1960s and 1970s focuses on the emerging human rights movement, especially the creation of the Ukrainian Helsinki Group, of which he was a founding member. He vividly recounts his encounters with the Soviet repressive apparatus, including his arrest and trial, and offers a rich picture of daily life in a Siberian prison camp and his internal exile in Kazakhstan. Imbued with the authors deep Christian convictions, this memoir sheds light on the key role faith played for some participants in the Soviet human rights movement, a movement that has most often been seen as having a secular inflection. It also provides a fresh look at the complex place of Ukrainian dissidents within the broader Soviet human rights movement, as well as the interplay between human rights advocates and other dissident groups in Soviet Ukraine."
    Keywords: Biography & Autobiography ; Personal Memoirs ; History ; Russia & The Former Soviet Union ; Religion ; Christian Theology ; thema EDItEUR::D Biography, Literature and Literary studies::DN Biography and non-fiction prose::DNC Memoirs ; thema EDItEUR::N History and Archaeology::NH History::NHQ History of other geographical groupings and regions ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity
    Language: English
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    Society for Libyan Studies | Society for Libyan Studies
    Publication Date: 2024-04-02
    Description: The buildings erected in his native city by the Roman emperor Septimius Severus are amongst the most impressive and best-preserved in the Roman world. Because of their unique state of preservation, they give an unparalleled insight into what an architect with an imperial commission could do, when he had the building-materials and technical expertise of the entire empire at his disposal.〈br/>〈br/>The buildings excavated by Italian teams between the two World Wars were examined in detail by Ward-Perkins between 1948 and 1953. The study was never completed in his lifetime, though the drawings and much of the text existed at least in draft form. The present publication puts these in the public domain, together with Ward-Perkins' authoritative insights into the process by which such a grand project was executed.
    Keywords: History ; Ancient ; Rome ; Social Science ; Archaeology ; Architecture ; History ; Ancient & Classical ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::A The Arts::AM Architecture::AMX History of architecture
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    Brill | Brill
    Publication Date: 2024-04-01
    Description: In The Jesuit Order as a Synagogue of Jews the author explains how Christians with Jewish ancestry went within less than forty years from having a leading role in the foundation and development of the Society of Jesus to being prohibited from membership in it. Readership: All those interested in converso and Jesuit history, the history of Catholicism, the history of late medieval and early modern Iberia and Italy, as well as Spanish literature historians, historians of law, and theologians.
    Keywords: History ; Jewish History & Culture ; Converso ; Ignatius of Loyola ; Rome ; Society of Jesus ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    CLACSO
    Publication Date: 2024-03-29
    Description: It is used to say that the first victim of a war is the truth. In fact, in a war in the strict sense or in a political war, the murder of the truth and the concealment of the facts occur profusely. It is not different in Brazil. Democracy was neither the first nor the only victim of the parliamentary coup (a.k.a. impeachment) in 2016. It was also the truth. Before the coup, and to justify it, anti-people and anti-national forces broadcasted, to exhaustion, a series of lies about the governments of the Workers Party (PT). The presentation of Dilma Rousseff
    Keywords: Political Science ; History ; Latin American Studies ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPH Political structure and processes::JPHV Political structures: democracy ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
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    Historic England | Historic England
    Publication Date: 2024-03-23
    Description: St Peter's, Barton-upon-Humber, is a redundant medieval church in the care of English Heritage. As a result of a major program of research carried out between 1978 and 2007, it is now the most intensively studied parish church in the UK. Excavations between 1978 and 1984 investigated most of the interior of the building, as well as a swathe of churchyard around its exterior. At the same time, a stone-by-stone record and detailed archaeological study of the fabric and furnishings of the church was undertaken, continuing down to 2007. The twin aims of the project were to understand the architectural history and setting of this complex, multi-period building (Volume 1, Parts 1 and 2) and to recover a substantial sample of the population for palaeopathological study (Volume 2). An extensive program of historical and topographical research also took place in order to set the archaeological evidence firmly in context.
    Keywords: Architecture ; History ; History ; Europe ; Medieval ; History ; Europe ; Great Britain ; thema EDItEUR::A The Arts::AM Architecture::AMX History of architecture ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Indiana University Press
    Publication Date: 2023-08-02
    Description: Women's Political and Social Thought: An Anthology is the first collection of source readings of women's important writings in political and social theory from ancient times to the twentieth century. It fills a major gap in materials available for teaching the history of political thought and opens paths for exploring the rich and diverse contributions of women as creators of theory. Not confined to works of feminist theory, this anthology makes available substantial selections from women's writings across the political spectrum and in varied forms, from epic poetry, fiction, drama, and autobiography to prose works on history, politics, religion, and philosophy. The twenty-five authors represented in the anthology include: the ancient Sumerian high priestess Enheduanna, Sappho of Lesbos, Diotima of Mantinea, Sei Shonagon, Catherine of Siena, Christine de Pizan, Margaret Cavendish, Sor Juana Ines de la Cruz, Mary Astell, Phillis Wheatley, Olympe de Gouges, Mary Wollstonecraft, Angelina and Sarah Grimké, Flora Tristan, Josephine Butler, Vera Figner, E. Pauline Johnson (Tekahionwake), Ida B. Wells-Barnett, Jane Addams, Rokeya Hossain, Rosa Luxemburg, Virginia Woolf, Ding Ling, Simone Weil, and Emma Mashinini. To illustrate the breadth of interests of women political theorists, the selections highlight works ranging from the political poetry and fiction of Enheduanna, Sappho, Sor Juana, Phillis Wheatley, Tekahionwake, and Ding Ling, to the Dialogue of St. Catherine, Christine de Pizan's Book of the Body Politic, Wollstonecraft's Vindication of the Rights of Men, Tristan's The Workers' Union, Butler's Government by Police, Wells-Barnett's Southern Horrors, Hossain's Sultana's Dream, Weil's Reflections Concerning the Causes of Liberty and Social Oppression, and Mashinini's Strikes Have Followed Me All My Life. The broad-ranging texts included in the volume cross many boundaries of time, space, class, race, sex, culture, genre, and ideology. The book includes a general introduction by Berenice Carroll, biographical introductions by Carroll or Smith for each of the authors, suggested readings for individual authors, and a selected bibliography.
    Keywords: American Studies ; Europe ; Gender ; History ; Politics ; Women ; World ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSJ Gender studies, gender groups
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    RAND Corporation
    Publication Date: 2024-03-29
    Description: This RAND report examines the U.S. Army role in Southeast Asia. Under current benign conditions, efforts should focus on supporting defense reform, addressing transnational threats, and balancing China. If the outlook deteriorates, the United States should increase security cooperation, conclude new regional basing agreements, expand disaster assistance, and create policies to encourage risk-averse Chinese behavior.
    Keywords: History ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWK Military and defence strategy ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
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    Publication Date: 2024-04-02
    Description: The Department of Defense (DoD) has developed new sensor technologies to support U.S. forces in Iraq and Afghanistan; these technologies are potentially useful for counterdrug operations along the southern U.S. border, but there are legal questions regarding how they may be used and how sensor information may be shared between federal agencies in domestic operations. This report examines federal law and DoD policy to answer these questions.
    Keywords: History ; Technology ; Political Science ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations::JPSD Diplomacy ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKS Social welfare and social services::JKSW Emergency services::JKSW1 Police and security services ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTM Military engineering
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    Publication Date: 2024-04-02
    Description: The Kurdistan Region of Iraq needs policy-relevant data to help improve infrastructure, encourage the private sector, attract foreign investment, and foster economic growth. The Kurdistan Region Statistics Office needs to build capacity to collect the data. RAND worked closely with the Office to build capacity by preparing, conducting, and analyzing the first round of a survey of the regional labor force.
    Keywords: History ; Sociology ; Law ; thema EDItEUR::N History and Archaeology::NH History::NHG Middle Eastern history ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNH Employment and labour law: general ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBC Social research and statistics
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
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    University of Georgia Press
    Publication Date: 2024-04-02
    Description: Revolution and Regeneration is a book about the aging of the "young men of 1776," the men who came to adulthood with the American Revolution, found their identity merged with the new republic they had created, and grew old as the nation matured. As they identified themselves with their nation's past, so they used that past to judge their own lives and what they had accomplished, or failed to accomplish. Revolution and Regeneration is a marriage of psychohistory and intellectual history, applying the principles of the psychology of maturation to a generation whose experiences were crucial to our history-the generation of Adams, Jefferson, Hamilton, and Madison. Their need for identity drove them to demand independence for themselves and their communities. Revolution and Regeneration tells their stories, from youth to old age. The Georgia Open History Library has been made possible in part by a major grant from the National Endowment for the Humanities: Democracy demands wisdom. Any views, findings, conclusions, or recommendations expressed in this collection, do not necessarily represent those of the National Endowment for the Humanities.
    Keywords: History ; American Studies ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTV Revolutions, uprisings, rebellions
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
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    University of Washington Press
    Publication Date: 2024-04-02
    Description: In 1835 young Chinese scholar Cai Tinglan was caught in a typhoon while sailing across the Taiwan Strait. He and his shipmates spent a harrowing week at sea before drifting to the coast of central Vietnam. With an escort of Vietnamese soldiers, Cai traveled north along the famous "Mandarin Road," meeting governors-general of each province he passed through along his overland journey to Fujian Province in China. Cai documented his experiences in Miscellany of the South Seas (Hainan zazhu), a vivid account of clothing, food, religious practices, government affairs, and other aspects of daily life in early Nguyễn dynasty Vietnam. Cai's encounters with diasporic Chinese show the Hokkien merchant community's penetration into Vietnamese society, while his warm embrace by Nguyễn officials illustrates a shared elite world of classical culture across international borders. In this first English translation, Kathlene Baldanza and Zhao Lu provide a comprehensive introduction that puts Cai's account in social, political, and economic context, along with extensive annotation and a glossary.
    Keywords: Asian Studies ; History ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history
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    Publication Date: 2024-04-02
    Description: This book offers new historical, legal and literary explorations of a status held by uncountable formerly enslaved persons in the Roman Empire: Junian Latinity. It is the first book in any language to provide comprehensive multi-disciplinary study of this status. Divided in two parts, the book sets the scene with six chapters that discuss the legal innovations that created Junian Latinity, as well as the historical contexts in which the status was conceived and in which it developed – from the late republican period to the early medieval world. Four chapters in the second book part offer then new research on key Latin literary texts to provide fresh insights into the role of Junian Latinity in Roman imperial society. The book makes a strong case for the centrality of Junian Latinity in the Roman Empire and the importance of its modern study.
    Keywords: History ; Classical Studies ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
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    Academic Studies Press | Academic Studies Press
    Publication Date: 2024-03-27
    Description: Filled with new elements that challenge common scholarly theses, this book acquaints the reader with the “Jewish problem” of sociology and provides what this academic discipline urgently needs: a one-volume history of the Sociology of the Holocaust. The story of why and how sociologists as well as the schools of sociological thought came to confront the Holocaust has never been entirely told. The volume offers original insights on the nature of American sociology with implications for the post-Holocaust sociology development.
    Keywords: Fiction ; Action & Adventure ; History ; Holocaust ; thema EDItEUR::F Fiction and Related items::FJ Adventure / action fiction ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTZ Genocide and ethnic cleansing::NHTZ1 The Holocaust ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR7 Second World War ; thema EDItEUR::1 Place qualifiers::1D Europe ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBL c 1940 to c 1949
    Language: English
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  • 47
    Publication Date: 2024-04-02
    Description: California’s Juvenile Justice Crime Prevention Act provides funds for counties to offer evidence-based programs for high-need juvenile probationers and at-risk youth. This report, based on the annual report to the state legislature, outlines the program’s success for six outcome measures (completion of probation, restitution, and community service; arrests; probation violations; and incarcerations) and county-required supplemental outcomes.
    Keywords: Law ; History ; Political Science ; Sociology ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNF Criminal law: procedure and offences::LNFQ Juvenile criminal law ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKS Social welfare and social services::JKSW Emergency services::JKSW1 Police and security services ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKV Crime and criminology
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  • 48
    Publication Date: 2024-04-02
    Description: Drawing from 140 recently declassified documents, this report comprehensively examines the organization, territorial designs, management, personnel policies, and finances of the Islamic State of Iraq (ISI) and al-Qa‘ida in Iraq. Analysis of the Islamic State predecessor groups is more than a historical recounting. It provides significant understanding of how ISI evolved into the present-day Islamic State and how to combat the group.
    Keywords: Political Science ; History ; thema EDItEUR::N History and Archaeology::NH History::NHG Middle Eastern history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPW Political activism / Political engagement::JPWL Terrorism, armed struggle
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    RAND Corporation
    Publication Date: 2024-03-29
    Description: On September 11, 2001, the United States was without a plan for military operations in Afghanistan. One was quickly created by the Defense Department and operations began October 7. The Taliban was toppled in less than two months. This report describes preparations at CENTCOM and elsewhere, Army operations and support activities, building a coalition, and civil-military operations in Afghanistan from October 2001 through June 2002.
    Keywords: History ; Political Science ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWK Military and defence strategy ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 51
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
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  • 52
    Publication Date: 2024-03-29
    Description: The composition of Air Force active and reserve forces is often contentious, especially during a force drawdown. This document seeks to inform force composition decisions by clarifying issues that affect the suitability of missions for assignment to the reserve components.
    Keywords: History ; Technology ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWK Military and defence strategy ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWC Military forces and sectors::JWCM Air forces and warfare ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTM Military engineering
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  • 53
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    University of North Carolina Press
    Publication Date: 2024-04-02
    Description: A decade before the American Civil War, James Churchwill Vaughan (1828-1893) set out to fulfill his formerly enslaved father's dying wish that he should leave America to start a new life in Africa. Over the next forty years, Vaughan was taken captive, fought in African wars, built and rebuilt a livelihood, and led a revolt against white racism, finally becoming a successful merchant and the founder of a wealthy, educated, and politically active family. Tracing Vaughan's journey from South Carolina to Liberia to several parts of Yorubaland (present-day southwestern Nigeria), Lisa Lindsay documents this "free" man's struggle to find economic and political autonomy in an era when freedom was not clear and unhindered anywhere for people of African descent. In a tour de force of historical investigation on two continents, Lindsay tells a story of Vaughan's survival, prosperity, and activism against a seemingly endless series of obstacles. By following Vaughan's transatlantic journeys and comparing his experiences to those of his parents, contemporaries, and descendants in Nigeria and South Carolina, Lindsay reveals the expansive reach of slavery, the ambiguities of freedom, and the surprising ways that Africa, rather than America, offered new opportunities for people of African descent.
    Keywords: History ; American Studies ; African Studies ; Sociology ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFA Social discrimination and social justice
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    Liverpool University Press
    Publication Date: 2024-03-26
    Description: An Open Access edition of this work is available on Modern Languages Open (https://www.modernlanguagesopen.org/). On 12 March 2018, Mauritius celebrated fifty years as an independent nation amidst much fanfare. Yet behind the nation's official image of multicultural 'unity in diversity' lurk deep socio-economic inequalities and inter-ethnic tensions that are insistently critiqued in its literature. Against this backdrop, this book analyses how the idea of belonging - a sense of attachment to, and identification with, a place or people - is problematised in a range of contemporary francophone Mauritian novels. The island-nation's complex history and the multi-ethnic composition of its modern-day population mean that belonging is a central but fraught issue in both reality and fiction. Waters explores how diverse forms of affirmative, affective belonging intersect with, and are frequently inhibited by, exclusionary 'politics of belonging' at communal, national or international levels. Using an eclectic theoretical approach to the central concept of belonging, Waters offers in-depth textual analyses of novels by leading Mauritian writers Nathacha Appanah, Ananda Devi, Shenaz Patel, Bertrand de Robillard, Amal Sewtohul and Carl de Souza. Despite their thematic and formal diversity, these novels are shown to be characterised by a common rejection of dominant discourses of ethnic, diasporic affiliation and by a common commitment to the ongoing, future-orientated project of Mauritian nationhood. As such, this book offers an original insight into the dynamics of belonging and exclusion in diverse, multi-ethnic societies.
    Keywords: Language & Literature ; European Studies ; African Studies ; History ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 56
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Keywords: hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 57
    Publication Date: 2024-04-02
    Description: This volume provides an ambitious synopsis of the complex, colourful world of textiles in ancient Mediterranean iconography. A wealth of information on ancient textiles is available from depictions such as sculpture, vase painting, figurines, reliefs and mosaics. Commonly represented in clothing, textiles are also present in furnishings and through the processes of textile production. The challenge for anyone analysing ancient iconography is determining how we interpret what we see. As preserved textiles rarely survive in comparable forms, we must consider the extent to which representations of textiles reflect reality, and critically evaluate the sources. Images are not simple replicas or photographs of reality. Instead, iconography draws on select elements from the surrounding world that were recognisable to the ancient audience, and reveal the perceptions, ideologies, and ideas of the society in which they were produced. Through examining the durable evidence, this anthology reveals the ephemeral world of textiles and their integral role in the daily life, cult and economy of the ancient Mediterranean.
    Keywords: History ; Ancient ; Rome ; History ; Ancient ; Design ; Textile & Costume ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::A The Arts::AK Design, Industrial and commercial arts, illustration::AKT Fashion and textile design
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  • 58
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
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    University of Arizona Press
    Publication Date: 2023-10-05
    Description: Grenville Goodwin was one of the leading field anthropologists during a crucial period in American Indian research-the 1930s. His letters from the field provide original source material on Western Apache beliefs and customs. They also reveal the attitudes and methods which made him so effective in his work. A dedicated and thorough ethnographer, Goodwin became familiar with every aspect of Western Apache culture. During this same period, Morris Opler was studying the Chiricahua and Mescalero Apache in New Mexico. In order to exchange information about their studies, Goodwin and Opler began corresponding. Both men were convinced that a long-overdue, systematic comparison of Apachean cultures would yield significant results.
    Keywords: Sociology ; Anthropology ; History ; American Indian Studies ; American Studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology::JHMC Social & cultural anthropology, ethnography ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJK History of the Americas
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    Academic Studies Press | Academic Studies Press
    Publication Date: 2023-08-17
    Description: This book will stimulate scholarly interest in the Ukrainian language and literature that have faced numerous challenges in the modern period. May be used in university courses on the history of Slavic languages and literatures, contemporary theories of nation-building and national identity as well as language contact and sociolinguistics.
    Keywords: Social Science ; History ; Russia & The Former Soviet Union ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJQ History of other lands
    Language: English
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    De Gruyter
    Publication Date: 2024-03-29
    Description: Anhand neuer Quellen werden die Berliner 'jüdischen Salons' um 1800 als ebenso lebendiges wie fragiles kommunikatives Netz präsentiert. Der Querschnitt durch die Salongesellschaft des Beispieljahrs 1794/95 beleuchtet eine Geselligkeitskultur, in der verschiedene Orte zu Salons wurden. Längsschnitte durch jahrzehntelang geführte Korrespondenzen erlauben die Frage nach Wechselwirkungen zwischen Salons und zeitgenössischen Emanzipationsdiskursen.
    Keywords: Jewish Studies ; Europe ; Germany ; HIS022000 ; History ; Jewish ; LIT004210 ; SOC049000 ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSR Social groups: religious groups and communities ; thema EDItEUR::5 Interest qualifiers::5P Relating to specific groups and cultures or social and cultural interests::5PG Relating to religious groups::5PGJ Relating to Jewish people and groups
    Language: English
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  • 62
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Keywords: systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 63
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
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    Maven Publishers
    Publication Date: 2022-04-28
    Description: The development of natural products requires the confluence of the modern techniques and integrated approaches in various fields of science and technology. Intention of this book is to highlight different aspects of globalization of traditional medicine with the focus on some crucial and contemporary issues on validation of natural products. Eminent scientists around the globe have contributed for this book on different issues of ethnopharmacology, traditional medicine and globalization. Given the importance on promotion and development of natural products, this book covers various aspects on revitalization of traditional medicines. The contributors have provided an insight into the modem aspects and future of traditional medicine inspired drug development, validation, safety related quality issues, sustainability and globalization. Bringing together expertise from academia and industry, this edited volume provides an overview of traditional medicine with wisdom and know-how in both innovation and commercialization, placing natural product research in a broader sense for readers. This edited volume contains 68 chapters emphasizing several thrust areas of ethnopharmacology and natural products. A wide diversity of chapters has been contributed by eminent personalities throughout the world including Dr. A. P. J. Abdul Kalam, Sri. Shekhar Dutt, Dr. Marco Leonti, Dr. G. A. Cordell, Dr. R. Verpoorte, Dr. P. J. Houghton, Dr. P. Pushpangadan, Dr. Y. K. Gupta, Dr. A.K.S. Rawat, Dr. S.K. Kulkarni, Dr. Colin W. Wright, Dr. S. C. Mandal, Dr. C. K. Katiyar, Dr. T. K. Mukherjee, Dr. S. Rajan, Dr. G. Schemda, Dr. P. K. Debnath, Dr. Bob Alkin, Dr. Elfin Y. Sukandar, Dr. N. Maity, Dr. A. K. Mitra, Dr. E. Hossain, Dr. H. Fukui, Dr. S.Bhadra, Dr. N. Neema, Dr. H. Mizuguchi, Dr. D. Chattopadhyay, Dr. T. Sen, Dr. Erdem Yesilada, Dr. S.K.Mitra, Dr. S.C. Bachar, Dr. S. Karmakar, Dr. G. B. J. Bailly, Dr. P. Haldar, Dr. Y. Oztruk, Dr. S. Pandit, and others. All representing the-state-of-the-art of the field, and thus would be interesting sources for information. This book will be of enormous help to the undergraduate and postgraduate students, researchers and academia and all others working in the area of Ethnopharmacology and natural product research. It will be an imperative addition to the libraries of technical and administrative personnel in the industries and Universities as a potential resource to update their knowledge.
    Keywords: Globalization ; traditional medicine ; bic Book Industry Communication::M Medicine
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    Central European University Press
    Publication Date: 2024-04-04
    Description: This social, cultural, and political history of Slavic Muslim women of the Yugoslav region in the first decades of the post-Ottoman era is the first to provide a comprehensive overview of the issues confronting these women. It is based on a study of voluntary associations (philanthropic, cultural, Islamic-traditionalist, and feminist) of the period. It is broadly held that Muslim women were silent and relegated to a purely private space until 1945, when the communist state “unveiled” and “liberated” them from the top down.  After systematic archival research in Bosnia, Croatia, Serbia, and Austria, Fabio Giomi challenges this view by showing:  How different sectors of the Yugoslav elite through association publications, imagined the role of Muslim women in post-Ottoman times, and how Muslim women took part in the construction or the contestation of these narratives.  How associa­tions employed different means in order to forge a generation of “New Muslim Women” able to cope with the post-Ottoman political and social circumstances.  And how Muslim women used the tools provided by the associations in order to pursue their own projects, aims and agendas.  The insights are relevant for today’s challenges facing Muslim women in Europe. The text is illustrated with exceptional photographs.
    Keywords: History ; Women ; History ; Europe ; Eastern ; Social Science ; Gender Studies ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups
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    Vandenhoeck & Ruprecht
    Publication Date: 2024-04-02
    Description: This volume presents the contributions to a symposium held on May 9th, 2009 at the Humanities Center at Harvard University that focused on the question of how peace and interstate stability were established and maintained in archaic and classical Greece. In this context, different perspectives and approaches, ranging from pragmatic political goals and the definition and interpretation of key terms such as eirene to the underlying norms and their relevance for the realpolitik, were discussed. The articles in this volume shed new light on the various political instruments that the Greeks developed and employed to avoid war and to keep and organize peace. They focus on the analysis of commonly accepted terms that provided the basis for a settlement between conflicting parties and the analysis of various political strategies, including one-time arrangements to limit military conflicts, diplomatic efforts, legally binding agreements and more comprehensive concepts of interstate stability.
    Keywords: History ; Ancient ; General ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history
    Language: English
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    University of California Press | University of California Press
    Publication Date: 2024-04-01
    Description: Ginseng and Borderland explores the territorial boundaries and political relations between Qing China and Chosŏn Korea during the period from the early seventeenth to the late nineteenth centuries. By examining a unique body of materials written in Chinese, Manchu, and Korean, and building on recent studies in New Qing History, Seonmin Kim adds new perspectives to current understandings of the remarkable transformation of the Manchu Qing dynasty (1636–1912) from a tribal state to a universal empire. This book discusses early Manchu history and explores the Qing Empire’s policy of controlling Manchuria and Chosŏn Korea. Kim also contributes to the Korean history of the Chosŏn dynasty (1392–1910) by challenging conventional accounts that embrace a China-centered interpretation of the tributary relationship between the two polities, stressing instead the agency of Chosŏn Korea in the formation of the Qing Empire. This study demonstrates how Koreans interpreted and employed this relationship in order to preserve the boundary—and peace—with the suzerain power. By focusing on the historical significance of the China-Korea boundary, this book defines the nature of the Qing Empire through the dynamics of contacts and conflicts under both the cultural and material frameworks of its tributary relationship with Chosŏn Korea.
    Keywords: History ; General ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Academic Studies Press | Academic Studies Press
    Publication Date: 2024-04-04
    Description: This groundbreaking book focuses on Alfred Dreyfus the man, with emphasis placed on his own writings, including his recently published prison workbooks and his letters to his wife Lucie. Through close reading of these documents, a much more sensitive, intellectual, and Jewish man is revealed than was previously suspected. He and Lucie, through their family connections and mutual loyalty, were interested in and supported the artistic, scientific, philosophical and historical movements that formed their Parisian milieu. But as an Alsatian Jew, Alfred was also critical of many aspects of technological and ideological developments, making his mentality one of skepticism as well as idealism.
    Keywords: History ; Jewish ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Keywords: Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
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    Archaeopress Publishing Ltd
    Publication Date: 2024-04-02
    Description: Western Mesoamerican Calendars and Writing Systems draws together studies by some of the world’s leading experts presented at a conference held in December 2020, ‘The Origins and Developments of Central Mexican Calendars and Writing Systems’. Mesoamerica is one of the few places to witness the independent invention of writing. From the earliest attestations of this intellectual feat in the Late Preclassic period 900 bc-ad 150), writing spread throughout Mesoamerica, developing and diversifying into a series of distinct and independent scripts. With the exception of the celebrated phonetic decipherments of Maya and Aztec writing, which are now well-documented and can be fully read, most Mesoamerican writing systems remain little studied and undeciphered. This is particularly true of the writing systems of Western Mesoamerica, the topic of this volume.Bringing together new research on Western Mesoamerican writing systems, some contributions focus on specific features of a given writing system, whereas others offer state-of-the-art syntheses of whole writing systems. Two contributions focus on the calendar in particular, and associated notations, as integral parts of writing systems. Chapters are included on the writing system of Teotihuacan, the Ñuiñe writing of the Mixteca Baja and adjoining areas, the writing system of the Epiclassic period and Aztec writing of the Postclassic. These writing systems represent more than a millennium of written records and literacy in Mesoamerica, spanning from the Early Classic to the Late Postclassic (from the 2nd to the sixteenth centuries ad). Aztec writing even continued in use for several decades after the Spanish invasion of Mexico (ad 1519-1521), which saw the introduction of the Latin alphabet and the gradual obsolescence of Mesoamerican logophonetic writing systems.
    Keywords: History ; Latin America ; Pre-columbian Era ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
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    Historic England | Historic England
    Publication Date: 2024-04-04
    Description: This volume offers a new and up-to-date synthesis of Lincoln's long history as a major city and regional capital, from prehistory to 1945. The 'City by the Pool' was a major religious centre long before the Roman invasion and from bronze-age shamans to early Baptists people have always been attracted here for spiritual as well as mundane purposes. The authors argue for the presence of a major ritual causeway of the late Bronze and Iron Age and outline the extent to which ritual monuments also contributed to the character of Roman Lincoln. This book is based on more than a hundred publicly-funded excavations and building surveys undertaken between 1945 and 2000. It surveys all aspects of city life, from housing and fortifications to the water supply and rubbish disposal. It includes a CD Rom with a Geographic Information System (GIS) and a relational data-base known as LARA (the Lincoln Archaeological Research Assessment).
    Keywords: Social Science ; Archaeology ; History ; Europe ; Great Britain ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
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    University of New Orleans Press
    Publication Date: 2024-04-02
    Description: This volume celebrates the study of Austria in the twentieth century by historians, political scientists and social scientists produced in the previous twenty-four volumes of Contemporary Austrian Studies. One contributor from each of the previous volumes has been asked to update the state of scholarship in the field addressed in the respective volume. The title Austrian Studies Today, then, attempts to reflect the state of the art of historical and social science related studies of Austria over the past century, without claiming to be comprehensive. The volume thus covers many important themes of Austrian contemporary history and politics since the collapse of the Habsburg Monarchy in 1918―from World War I and its legacies, to the rise of authoritarian regimes in the 1930s and 1940s, to the reconstruction of republican Austria after World War II, the years of Grand Coalition governments and the Kreisky era, all the way to Austria joining the European Union in 1995 and its impact on Austria's international status and domestic politics.
    Keywords: History ; Political Science ; European Studies ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    Bloomsbury Academic
    Publication Date: 2023-11-16
    Description: Women’s Activism and "Second Wave" Feminism situates late 20th century feminisms within a global framework of women’s activism. Its chapters, written by leading international scholars, demonstrate how issues of heterogeneity, transnationalism, and intersectionality have transformed understandings of historical feminism. It is no longer possible to imagine that feminism has ever fostered an unproblematic sisterhood among women blind to race, ethnicity, class, sexuality, nationality and citizenship status. The chapters in this collection modify the "wave" metaphor in some cases and in others re-periodize it. By studying individual movements, they collectively address several themes that advance our understandings of the history of feminism, such as the rejection of "hegemonic" feminism by marginalized feminist groups, transnational linkages among women’s organizations, transnational flows of ideas and transnational migration.
    Keywords: History ; History of Feminism ; Women's activism ; Transnationalism ; Intersectionality ; Hisotrical Feminism ; Feminist Waves ; Gender Studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFK Feminism & feminist theory
    Language: English
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    The White Horse Press | The White Horse Press
    Publication Date: 2024-04-14
    Description: Deserts – vast, empty places where time appears to stand still. The very word conjures images of endless seas of sand, blistering heat and a virtual absence of life. However, deserts encompass a large variety of landscapes and life beyond our stereotypes. As well as magnificent Saharan dunes under blazing sun, the desert concept encompasses the intensely cold winters of the Gobi, the snow-covered expanse of Antarctica and the rock-strewn drylands of Pakistan. Deserts are environments in perpetual flux and home to peoples as diverse as their surroundings, peoples who grapple with a broad spectrum of cultural, political and environmental issues as they wrest livelihoods from marginal lands. The cultures, environments and histories of deserts, while fundamentally entangled, are rarely studied as part of a network. To bring different disciplines together, the 1st Oxford Interdisciplinary Deserts Conference in March 2010 brought together a wide range of researchers from backgrounds as varied as physics, history, archaeology anthropology, geology and geography. This volume draws on the diversity of papers presented to give an overview of current research in deserts and drylands. Readers are invited to explore the wide range of desert environments and peoples and the ever-evolving challenges they face.
    Keywords: Nature ; Ecosystems & Habitats ; Deserts ; History ; Essays ; Nature ; Essays ; thema EDItEUR::W Lifestyle, Hobbies and Leisure::WN Nature and the natural world: general interest::WNW The Earth: natural history: general interest ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::W Lifestyle, Hobbies and Leisure::WN Nature and the natural world: general interest
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    University of Michigan Press
    Publication Date: 2024-03-28
    Description: The Holocaust is considered a singularly atrocious event in human history, and many people have studied its causes. Yet few questions have been asked about the ways in which West Germans have "forgotten," unlearned, or reconstructed the racial beliefs at the core of the Nazi state in order to build a democratic society. This study looks at ethnic drag as one particular kind of performance that reveals how postwar Germans lived, disavowed, and contested "Germanness" in its complex racial, national, and sexual dimensions.
    Keywords: German Studies ; Cultural Studies ; Theater and Performance ; History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups
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  • 81
    Publication Date: 2024-03-29
    Description: Freedom of movement (FoM) is the actual or perceived degree to which individuals or groups can move from place to place within a given environment or into and out of that environment. Focusing specifically on Afghanistan, this examination considers actual and perceived FoM for a range of groups and profiles the factors that influence them and affect data reporting in potentially misleading ways.
    Keywords: Political Science ; History ; Technology ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWK Military and defence strategy ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations::JPSH Espionage and secret services ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTM Military engineering
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    RAND Corporation
    Publication Date: 2024-04-02
    Description: This book examines the strategic choices that American and Chinese decisionmakers face regarding sea power in the Western Pacific, shaped by geography, history, technology, and politics. In particular, the author explores the potential for cooperation on maritime security in the Western Pacific, and how the United States might pursue such cooperation as part of a broader strategy to advance its interests in the region.
    Keywords: History ; Political Science ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWC Military forces and sectors::JWCK Naval forces and warfare ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
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    Amsterdam University Press | Pallas Publications
    Publication Date: 2024-04-01
    Description: Women and Power at the French Court, 1483—1563 explores the ways in which a range of women “ as consorts, regents, mistresses, factional power players, attendants at court, or as objects of courtly patronage “ wielded power in order to advance individual, familial, and factional agendas at the early sixteenth-century French court. Spring-boarding from the burgeoning scholarship of gender, the political, and power in early modern Europe, the collection provides a perspective from the French court, from the reigns of Charles VIII to Henri II, a time when the French court was a renowned center of culture and at which women played important roles. Crossdisciplinary in its perspectives, these essays by historians, art and literary scholars investigate the dynamic operations of gendered power in political acts, recognized status as queens and regents, ritualized behaviors such as gift-giving, educational coteries, and through social networking, literary and artistic patronage, female authorship, and epistolary strategies.
    Keywords: History ; women ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
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  • 85
    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
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    Fordham University Press
    Publication Date: 2023-10-05
    Description: Okinawan life, at the crossroads of American militarism and Japanese capitalism, embodies a fundamental contradiction to the myth of the monoethnic state. Suspended in a state of exception, Okinawans have never been officially classified as colonial subjects of the Japanese empire or the United States, nor have they ever been treated as equal citizens of Japan. As a result, they live amid one of the densest concentrations of U.S. military bases in the world. By bringing Foucauldian biopolitics into conversation with Japanese Marxian theorizations of capitalism, Alegal uncovers Japan's determination to protect its middle class from the racialized sexual contact around its mainland bases by displacing them onto Okinawa, while simultaneously upholding Okinawa as a symbol of the infringement of Japanese sovereignty figured in terms of a patriarchal monoethnic state. This symbolism, however, has provoked ambivalence within Okinawa. In base towns that facilitated encounters between G.I.s and Okinawan women, the racial politics of the United States collided with the postcolonial politics of the Asia Pacific. Through close readings of poetry, reportage, film, and memoir on base-town life since 1945, Shimabuku traces a continuing failure to "become Japanese." What she discerns instead is a complex politics surrounding sex work, tipping with volatility along the razor's edge between insurgency and collaboration. At stake in sovereign power's attempt to secure Okinawa as a military fortress was the need to contain alegality itself-that is, a life force irreducible to the legal order. If biopolitics is the state's attempt to monopolize life, then Alegal is a story about how borderland actors reclaimed the power of life for themselves. In addition to scholars of Japan and Okinawa, this book is essential reading for anyone interested in postcolonialism, militarism, mixed-race studies, gender and sexuality, or the production of sovereignty in the modern world. Alegal is available from the publisher on an open-access basis.
    Keywords: Sociology ; History ; Asian Studies ; Political Science ; Language & Literature ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSL Ethnic studies ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJF Asian history ; bic Book Industry Communication::H Humanities::HB History::HBT History: specific events & topics::HBTQ Colonialism & imperialism ; bic Book Industry Communication::D Literature & literary studies::DS Literature: history & criticism::DSA Literary theory
    Language: English
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    RAND Corporation
    Publication Date: 2024-04-14
    Description: Current DoD force planning processes assume that U.S. military interventions are serially independent over time. This report challenges this assumption, arguing that interventions occur in temporally dependent clusters in which the likelihood of an intervention depends on interventions in the recent past. Integrating the concept of temporal dependence into DoD planning processes could help planners develop more appropriate force estimates.
    Keywords: History ; Statistics ; Technology ; thema EDItEUR::U Computing and Information Technology::UN Databases::UNA Database design and theory ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWK Military and defence strategy ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBT Probability and statistics
    Language: English
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  • 88
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    University of Hawai'i Press
    Publication Date: 2024-03-26
    Description: From Sung times, and throughout the Ming period, one of the dominant philosophies of China had been a dualistic rationalism thought to be firmly grounded on the classics. Tai Chen (1723-1777) was a scholar and philosopher during the Ch'ing period- a time when China produced few philosophic thinkers. He was the greatest of these, and his views are embodied chiefly in Yuan Shan and in Meng Tzu txu-yi shu-cheng. In place of the prevailing Sung dualism, Tai Chen propounded a rationalistic monism seldom before insinuated in a Chinese philosophy. He declines to accept current dogmas and preferred to seek his own truths. His commentaries opposed the time-honored interpretations of Chu Hsi, and he discredited them on purely philosophical grounds. But with few disciples to carry on his teachings, he was virtually forgotten or ignored in China for more than a hundred years after his death. It was not until early in the present century- with China under the pressures of Western aggression and internal disorders-that Tai Chen's nearness to Western thought was rediscovered and his important role in the history of philosophy recognized. Curiously, this first of China's Western-oriented philosophers even today remains little known in the West and his major writings largely untranslated.
    Keywords: Philosophy ; History ; thema EDItEUR::D Biography, Literature and Literary studies::DN Biography and non-fiction prose::DNB Biography: general ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought::QDHC East Asian and Indian philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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  • 89
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    University of London Press | University of London Press
    Publication Date: 2024-04-01
    Description: Creative Spaces: Urban Culture and Marginality is an interdisciplinary exploration of the different ways in which marginal urban spaces have become privileged locations for creativity in Latin America. The essays within the collection reassess dominant theoretical notions of ‘marginality’ in the region and argue that, in contemporary society, it invariably allows for (if not leads to) the production of the new. While Latin American cities have, since their foundation, always included marginal spaces (due, for example, to the segregation of indigenous groups), the massive expansion of informal housing constructed on occupied land in the second half of the twentieth century have brought them into the collective imaginary like never before. Originally viewed as spaces of deprivation, violence, and dangerous alterity, the urban margins were later romanticized as spaces of opportunity and popular empowerment. Instead, this volume analyses the production of new art forms, political organizations and subjectivities emerging from the urban margins in Latin America, neither condemning nor idealizing the effects they produce. To account for the complex nature of contemporary urban marginality, the volume draws on research from a wide spectrum of disciplines, ranging from cultural and urban studies to architecture and sociology. Thus the collection analyzes how these different conceptions of marginal spaces work together and contribute to the imagined and material reality of the wider city.
    Keywords: marginality ; liminality ; urbanity ; diaspora ; migration ; population ; History ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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  • 90
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
    Language: English
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  • 91
    Publication Date: 2023-10-05
    Description: Congress enacted the Terrorism Risk Insurance Act (TRIA) in 2002, in response to terrorism insurance becoming unavailable or extremely costly in the wake of the 9/11 attacks. TRIA is set to expire at the end of 2014, and Congress is considering the appropriate government role in terrorism insurance markets. This policy brief examines the potential national security implications of allowing TRIA to expire.
    Keywords: Political Science ; History ; Business ; bic Book Industry Communication::K Economics, finance, business & management::KF Finance & accounting::KFF Finance::KFFN Insurance & actuarial studies ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJK History of the Americas ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPW Political activism::JPWL Terrorism, armed struggle
    Language: English
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  • 92
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 93
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    NYU Press
    Publication Date: 2024-04-02
    Description: Why, asks Daniel Rancour-Laferriere in this controversial book, has Russia been a country of suffering? Russian history, religion, folklore, and literature are rife with suffering. The plight of Anna Karenina, the submissiveness of serfs in the 16th and 17th centuries, ancient religious tracts emphasizing humility as the mother of virtues, the trauma of the Bolshevik revolution, the current economic upheavals wracking the country-- these are only a few of the symptoms of what The Slave Soul of Russia identifies as a veritable cult of suffering that has been centuries in the making. Bringing to light dozens of examples of self-defeating activities and behaviors that have become an integral component of the Russian psyche, Rancour-Laferriere convincingly illustrates how masochism has become a fact of everyday life in Russia. Until now, much attention has been paid to the psychology of Russia's leaders and their impact on the country's condition. Here, for the first time, is a compelling portrait of the Russian people's psychology.
    Keywords: History ; thema EDItEUR::N History and Archaeology::NH History::NHQ History of other geographical groupings and regions
    Language: English
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  • 94
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    Pennsylvania State University Press | University of Pennsylvania Press
    Publication Date: 2024-04-02
    Description: In 1803 in the colonial South American city of La Plata, Doña Martina Vilvado y Balverde presented herself to church and crown officials to denounce her husband of more than four years, Don Antonio Yta, as a "woman in disguise." Forced to submit to a medical inspection that revealed a woman's body, Don Antonio confessed to having been María Yta, but continued to assert his maleness and claimed to have a functional "member" that appeared, he said, when necessary. Passing to América is at once a historical biography and an in-depth examination of the sex/gender complex in an era before "gender" had been divorced from "sex." The book presents readers with the original court docket, including Don Antonio's extended confession, in which he tells his life story, and the equally extraordinary biographical sketch offered by Felipa Ybañez of her "son María," both in English translation and the original Spanish. Thomas A. Abercrombie's analysis not only grapples with how to understand the sex/gender system within the Spanish Atlantic empire at the turn of the nineteenth century but also explores what Antonio/María and contemporaries can teach us about the complexities of the relationship between sex and gender today. Passing to América brings to light a previously obscure case of gender transgression and puts Don Antonio's life into its social and historical context in order to explore the meaning of "trans" identity in Spain and its American colonies. This accessible and intriguing study provides new insight into historical and contemporary gender construction that will interest students and scholars of gender studies and colonial Spanish literature and history. This book is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem)-a collaboration of the Association of American Universities, the Association of University Presses and the Association of Research Libraries-and the generous support of New York University. Learn more at the TOME website: openmonographs.org.
    Keywords: History ; Latin American Studies ; European Studies ; Feminist & Women's Studies ; Gender Studies ; Law ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSJ LGBTQ+ Studies / topics ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAZ Legal history
    Language: English
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  • 95
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    Vandenhoeck & Ruprecht
    Publication Date: 2024-04-02
    Description: Ancient Rome has always been considered a compendium of City and World. In the Renaissance, an era of epistemic fractures, when the clash between the 'new science' (Copernicus, Galileo, Vesalius, Bacon, etcetera) and the authority of ancient texts produced the very notion of modernity, the extended and expanding geography of ancient Rome becomes, for Shakespeare and the Elizabethans, a privileged arena in which to question the nature of bodies and the place they hold in a changing order of the universe. Drawing on the rich scenario provided by Shakespeare's Rome, and adopting an interdisciplinary perspective, the authors of this volume address the way in which the different bodies of the earthly and heavenly spheres are re-mapped in Shakespeare's time and in early modern European culture. More precisely, they investigate the way bodies are fashioned to suit or deconstruct a culturally articulated system of analogies between earth and heaven, microcosm and macrocosm. As a whole, this collection brings to the fore a wide range of issues connected to the Renaissance re-mapping of the world and the human. It should interest not only Shakespeare scholars but all those working on the interaction between sciences and humanities.
    Keywords: History ; Europe ; Renaissance ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 96
    Publication Date: 2023-12-21
    Description: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Keywords: R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
    Language: English
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  • 97
    Publication Date: 2024-03-29
    Description: RAND supported the Kurdistan Regional Government in its aims to restructure its Ministry of Education, develop a plan for a school quality assurance system, review effectiveness of monitoring and support of private schools, and assess the quality of in-service teacher training. RAND researchers conducted interviews, reviewed literature, examined case studies in other countries, provided analysis, and developed implementation guidelines.
    Keywords: Education ; History ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education::JNMT Teacher training ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJF Asian history::HBJF1 Middle Eastern history ; thema EDItEUR::J Society and Social Sciences::JN Education::JNK Educational administration and organization ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education::JNMT Teacher training ; thema EDItEUR::N History and Archaeology::NH History::NHG Middle Eastern history
    Language: English
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  • 98
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    Ledizioni
    Publication Date: 2023-12-21
    Description: This study investigates eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in such reference works as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole. A vast amount of reference works was produced for experts and non-experts alike: medical topics were common in social settings, in personal and communal letters, in specialised journals, in pamphlets and in magazines. All this unprecedented activity certainly contributed to the vernacularisation, and the dissemination of medicine in different kinds of works and different text types. The texts examined in the study are representative of their authors’ effort to expand medical knowledge and to define medicine as an independent science based on strict observation, as well as to establish intelligibility within and outside the disciplinary discourse community.
    Keywords: R5-920 ; english ; medicine ; language ; communication ; bic Book Industry Communication::M Medicine
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  • 99
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: Extracellular vesicles (EVs) are particles wrapped in a lipid bilayer membrane and are naturally released from cells. This kind of cargo vessel is a nanostructure that mainly transfers lipids, proteins, various nucleic acid fragments, and metabolic components to neighboring cells or distant parts of the body through the circulatory system. EVs are of great significance to the communication mechanism between cells. This book collects feature articles to enhance our understanding of the biological characteristics of EVs and their potential applications.
    Keywords: extracellular vesicle ; precision oncology ; cancer biomarker ; prostate cancer ; drug delivery ; extracellular vesicles ; lysosome ; nanocarriers ; ultrasound ; size exclusion chromatography ; differential ultracentrifugation ; head and neck squamous cell carcinoma (HNSCC) ; exosomes ; cancer ; biomarker ; diagnostic ; therapy ; liquid biopsy ; small extracellular vesicles (sEV) ; tumor-derived exosomes (TEX) ; melanoma cell-derived exosomes (MTEX) ; proteomics ; tumor microenvironment ; biomarkers ; ectosomes ; neoplasia ; microvesicles ; small extracellular vesicles ; isolation ; purification ; size-exclusion chromatography ; ultracentrifugation ; sucrose density cushion ; lymph node ; spleen ; solid tissue ; microvesicle ; exosome ; cancer therapeutic ; drug carrier ; flow cytometry ; immunophenotyping ; swarm detection ; tumor-associated macrophages ; macrophage polarization ; mannose receptor ; HIV-1 Nef ; glioblastoma ; microRNA ; immunoprecipitation ; CD44 ; human milk ; nutrient ; microbiota ; microRNAs ; nanocommunicator ; diagnostic biomarker ; drug delivery vehicle ; personalized cancer immunotherapy ; therapeutic agents ; cell-to-cell communication ; ionising radiation ; non-targeted effects ; signalling ; imaging flow cytometry ; biomarker reservoirs ; cancer diagnostics ; disease monitoring ; large EVs ; ovarian cancer cells ; ES-2 ; OAW-42 ; adipose tissue origin mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Temple University Press
    Publication Date: 2024-04-02
    Description: Throughout the late nineteenth century the hard coal industry was a major employer in Pennsylvania. The Commonwealth’s anthracite regions also played an important role in the economic development of the nation. Anthracite stimulated many pioneering developments in American railroading and provided important fuel to the iron industry. The hard-coal regions were among the first areas in Pennsylvania to yield to corporate domination. Yet their history, notably between the well-documented "Molly Maguires" and the coal strike of 1902, was largely unexplored. Although the area can be placed within the mainstream of American history, the anthracite regions developed a unique identity, the development of which can be found by studying the largest group in the area, the mine workers, and their problems between 1869 and 1897. Aurand documents and analyzes the problems facing mine workers, the resulting collective approach to addressing them, and the role of labor in the formation of a laboring class identity.
    Keywords: History ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNX Industrial relations, occupational health and safety::KNXN Industrial arbitration and negotiation
    Language: English
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