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  • Books  (2,244)
  • Q1-390  (1,523)
  • thema EDItEUR::N History and Archaeology::NH History::NHD European history  (721)
  • English  (2,203)
  • Portuguese  (42)
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  • Books  (2,244)
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  • 1
    Publication Date: 2024-04-05
    Description: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.
    Keywords: QD1-999 ; Q1-390 ; Nanoparticles ; Gene Therapy ; Immunotherapy ; bioimaging ; theranostics ; nanomaterials ; Drug delivery ; Nanomedicine ; Cancer ; Phototherapy ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 2
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    Johns Hopkins University Press
    Publication Date: 2024-04-02
    Description: This book reviews the course of NATO policy on German reunification from the perspective of West German preferences and Bonn's endeavors to have them respected in the diplomatic efforts of the major allies. With its accession to NATO, the West German government under Adenauer continued its policy of rehabilitating the German people in the eyes of the Western political community by playing a willing and sometimes leading role in joint ventures whose purpose was said to transcend the nation-state.
    Keywords: European history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 3
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    Central European University Press
    Publication Date: 2024-04-02
    Description: With forty-two extensively annotated maps, this atlas offers novel insights into the history and mechanics of how Central Europe’s languages have been made, unmade, and deployed for political action. The innovative combination of linguistics, history, and cartography makes a wealth of hard-to-reach knowledge readily available to both specialist and general readers. It combines information on languages, dialects, alphabets, religions, mass violence, or migrations over an extended period of time. The story first focuses on Central Europe’s dialect continua, the emergence of states, and the spread of writing technology from the tenth century onward. Most maps concentrate on the last two centuries. The main storyline opens with the emergence of the Western European concept of the nation, in accord with which the ethnolinguistic nation-states of Italy and Germany were founded. In the Central European view, a “proper” nation is none other than the speech community of a single language. The Atlas aspires to help users make the intellectual leap of perceiving languages as products of human history and part of culture. Like states, nations, universities, towns, associations, art, beauty, religions, injustice, or atheism—languages are artefacts invented and shaped by individuals and their groups.
    Keywords: Ethnolinguistics, Nation states, Language politics, Nationalism, Sociolinguistics, Areal linguistics ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology
    Language: English
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-20
    Description: Anthropogenic greenhouse gas (GHG) emissions are dramatically influencing the environment, and research is strongly committed to proposing alternatives, mainly based on renewable energy sources. Low GHG electricity production from renewables is well established but issues of grid balancing are limiting their application. Energy storage is a key topic for the further deployment of renewable energy production. Besides batteries and other types of electrical storage, electrofuels and bioderived fuels may offer suitable alternatives in some specific scenarios. This Special Issue includes contributions on the energy conversion technologies and use, energy storage, technologies integration, e-fuels, and pilot and large-scale applications.
    Keywords: Q1-390 ; QC1-999 ; n/a ; PV ; GHG savings ; lithium-ion battery (LIB) ; probability prediction ; decarbonization ; supercapacitor (SC) ; least squares support vector machine ; EV fleet forecasts ; alternative maritime power (AMP) ; Markov chain ; feasibility study ; D funding ; hybrid power system ; numerical analysis ; ship structure ; optimal sizing ; cellulosic ethanol ; electric vehicles EV ; biofuel ; green ship ; R&amp ; bulk carrier ; molten carbonate fuel cell system ; sparse Gaussian process regression ; power-to-gas ; combination method ; charging infrastructure ; jet fuel ; flow characteristics ; hybrid refinery ; LNG-fueled ship ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: English
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  • 5
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 6
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    EPURE, Éditions et presses universitaires de Reims
    Publication Date: 2024-04-02
    Description: In recent years, through novels and television series ("Vikings", "Millennium", "Borgen" or "Occupied"), Nordic culture has become more visible internationally. At the same time, researchers are questioning what the North is, its conceptualisation, its cultural implications, its geographical characteristics, its social and political challenges. This volume is part of the current debate on the Nordic imaginary based on a notion, Nordicity, which intersects with borealism. Plural and mobile, the North inspires both scriptural and figurative production based on desire, dream, fascination or fantasy. The real, tangible and contingent North is only the apparent surface of a manufactured and invented North. How can we express northernness today? Is a theory of the North possible? This volume attempts to answer these questions by bringing together contributions from researchers in Nordic studies, literature, linguistics and the humanities: each is given the opportunity to define his own conception of Nordicity. Ces dernières années, à travers romans et sériés télévisées ("Vikings", "Millennium", "Borgen" ou "Occupied"), la culture nordique a gagné en visibilité internationale. Simultanément, les chercheurs s'interrogent sur ce qu’est le Nord, sa conceptualisation, ses implications culturelles, ses caractéristiques géographiques, ses enjeux sociaux et politiques. Ce volume s’insère dans le débat actuel sur l’imaginaire nordique à partir d’une notion – la nordicité – qui interagit tout particulièrement avec le boréalisme. Pluriel et mouvant, moteur constant de redéfinitions, le Nord inspire une fabrication tant scripturale que figurale fondée sur le désir, le rêve, la fascination ou le fantasme. Le Nord réel, tangible contingent, n’est que la surface apparente d’un Nord fabriqué et inventé. Comment dire aujourd’hui la nordicité? Une théorie du Nord est-elle possible? Ce volume s’attache à répondre à ces différentes questions en réunissant les contributions de chercheurs en études nordiques, littérature, linguistique ou sciences humaines: chacun dispose ici d’une carte blanche pour définir sa conception de la nordicité.
    Keywords: Nordicity ; Scandinavia ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::1 Place qualifiers::1D Europe::1DN Northern Europe, Scandinavia ; thema EDItEUR::2 Language qualifiers::2A Indo-European languages::2AC Germanic and Scandinavian languages::2ACS Scandinavian languages ; thema EDItEUR::2 Language qualifiers::2A Indo-European languages::2AC Germanic and Scandinavian languages::2ACB English::2ACBC Middle English
    Language: French , English
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  • 7
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    University of Michigan Press | University of Michigan Press
    Publication Date: 2024-04-02
    Description: "Printing and Prophecy: Prognostication and Media Change 1450-1550 examines prognostic traditions and late medieval prophetic texts in the first century of printing and their effect on the new medium of print. The many prophetic and prognostic works that followed Europe's earliest known printed book—not the Gutenberg Bible, but the Sibyl's Prophecy, printed by Gutenberg two years earlier and known today only from a single page—over the next century were perennial best sellers for many printers, and they provide the modern observer with a unique way to study the history and inner workings of the print medium. The very popularity of these works, often published as affordable booklets, raised fears of social unrest. Printers therefore had to meet customer demand while at the same time channeling readers' reactions along approved paths. Authors were packaged—and packaged themselves—in word and image to respond to the tension, while leading figures of early modern culture such as Paracelsus, Martin Luther, and Sebastian Brant used printed prophecies for their own purposes in a rapidly changing society. Based on a wide reading of many sources, Printing and Prophecy contributes to the study of early modern literature, including how print changed the relationship among authors, readers, and texts. The prophetic and astrological texts the book examines document changes in early modern society that are particularly relevant to German studies and are key texts for understanding the development of science, religion, and popular culture in the early modern period. By combining the methods of cultural studies and book history, this volume brings a new perspective to the study of Gutenberg and later printers."
    Keywords: History ; Astrology ; Latin ; Lichtenberger ; Practica (astrology) ; Prophecy ; Woodcut ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 8
    Publication Date: 2023-12-20
    Description: Durante séculos, diversos conhecimentos elaborados e mantidos por grupos sociais considerados à margem da sociedade receberam a classificação de conhecimento popular e conhecimento vulgar, o que demarcou o distanciamento entre esses saberes e o mundo das ciências. Este livro destaca, sob a perspectiva da etnobiologia, o potencial dos saberes tradicionais na construção de ações sustentáveis, refletindo sobre possíveis benefícios para a sociedade. Os autores oferecem análises e informações sobre a contribuição do conhecimento tradicional para a conservação da biodiversidade, para a segurança alimentar e para a saúde, por meio da utilização das plantas medicinais e de outras práticas nativas. O leitor vai perceber que, em muitos momentos, a imposição do mercado ou de pressões políticas não acarretou necessariamente uma melhoria real na alimentação ou na saúde da maior parte da população, como no exemplo dos problemas decorrentes de uma nutrição baseada em alimentos industrializados.
    Keywords: Q1-390 ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: Portuguese
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  • 9
    Publication Date: 2024-04-05
    Description: In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.
    Keywords: RC321-571 ; Q1-390 ; Down Syndrome ; Amyotrophic Lateral Sclerosis ; Parkinson's disease ; aluminium ; Iron ; TBI ; Cognition ; Copper ; Alzheimer's disease ; Zinc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 10
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-07
    Description: This edited volume explores a variety of aspects of associative governance, providing detailed case studies of associations and associational governance in Scandinavia. Theoretically developing a concept and approach of associative governance, the book sheds light on a dynamic way of perceiving associative aspects of community and commercial life that has been hitherto underexplored and undertheorized. It shows how governance by associations may be conducted not only bottom‑up by self‑organized and voluntary participation, but also top‑down by authoritative incorporation through government, and – not least – in multifarious interstices in between. New section by exploring a vibrant panoply of dimensions of associative governance, empirically grounded in historical analyses of a wide range of organizational repertoires, the book may provide novel insights into the significant role of associative governance in Scandinavia over the past two centuries. Finally, it provides research‑based knowledge about how to maintain “good political and economic institutions” in the future and a more holistic and dynamic approach to the literature on The Nordic model. The book will be of key interest to scholars and students of Nordic and Scandinavian studies, history, sociology, political science, marketing, social policy, organization theory, and public management. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution‑Non Commercial‑No Derivatives (CC‑BY‑NC‑ND) 4.0 license.
    Keywords: Nordic societies ; Scandinavia ; governance ; Scandinavian societies ; Nordic governance ; associative governance ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTM Regional / International studies ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJU Organizational theory and behaviour ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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