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  • 1
    Online Resource
    Online Resource
    ESR Spectroscopy for Life Science Applications: An Introduction (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Radiology. ; Spectrum analysis. ; Pharmaceutical chemistry. ; Nutrition   . ; Biomedical Research. ; Radiology. ; Spectroscopy. ; Pharmaceutics. ; Nutrition.
    Description / Table of Contents: Ch 1: Electron Spin Resonance- An Introdcution -- Ch 2: ESR – Applications in Healthcare and Pharmaceutical Science -- Ch 3: ESR Applications in Paleontology and Geochronology -- Ch 4: ESR Applications in Food Science.
    Abstract: This book introduces the audience with basic theoretical and experimental aspects of Electron Spin Resonance (ESR) Spectroscopy. It further talks about ESR spectroscopy applications in Healthcare & Pharmaceutical Science, Paleontology & Geochronology and Food Science. Mathematical details have been kept to a necessary minimum and emphasis is given to highlight the applications of the technique.
    Type of Medium: Online Resource
    Pages: X, 72 p. 32 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030641986
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    URL: https://doi.org/10.1007/978-3-030-64198-6
    DOI: 10.1007/978-3-030-64198-6
    DDC: 610.72
    Language: English
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  • 2
    Online Resource
    Online Resource
    LGBT Populations and Cancer in the Global Context (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical policy. ; Quality of life. ; Biomedical Research. ; Health Policy. ; Quality of Life Research.
    Description / Table of Contents: Foreword: Challenges & Opportunities for LGBT Populations and Cancer in Global Oncology -- Introduction -- Africa -- A Double Dose Of Stigma – Being Gay And Living With Cancer In Kenya -- Sexual Orientation, Gender Identity and Cancer in South Africa -- Americas -- Making the Situation of TLGBI People around Cancer visible: Observations from the Andean Region -- Cancer Care Challenges for the LGBT Population in Brazil -- Cancer and the SGM Population in Canada and the United States of America -- South-East Asia -- The South-East Asia Region: Societal Conditions for LGBT Health and Cancer Research -- Europe -- Foreword: The Eurocentralasian Lesbian* Community Perspective on Cancer and LBQ women: Advocating for more Research and Activism Collaboration -- LGBT+ and Cancer in the WHO European Region: Current Situation in 12 Eastern European and Central Asian Countries -- Sexual and Gender Minorities and Cancer in Germany: The Striking Absence of Understanding their Cancer-related Needs -- LGBT Populations and Cancer in the UK -- Eastern Mediterranean -- LGBT Populations and Cancer in the Eastern Mediterranean Region: Insights and Challenges with a Focus on Lebanon -- Western Pacific -- LGBT Populations and Cancer in Australia and New Zealand -- Challenges in Cancer Control Confronting the LGBT Population in China: Health Risks, Unique Barriers, and Unmet Needs -- What Have We Learned about Cancer and the Global LGBT Community? -- Index.
    Abstract: Lesbian, Gay, Bisexual, and Transgender (LGBT) also known as sexual and gender minority (SGM) populations have been the focus of global attention. Most importantly, LGBT populations have been addressed in the context of human rights in multiple reports and other activities by the United Nations and other international organizations. There is great variation among countries in the recognition of LGBT individuals’ human rights. A global focus on LGBT populations’ health is still limited, with the notable exception of HIV research. This book on LGBT populations and cancer in the global context is, therefore, an important step in that it will broaden the focus on LGBT populations’ health. Globally, cancer is the second leading cause of death. Cancer morbidity and mortality are increasing disproportionately among populations in lower-income countries. A review conducted by the World Health Organization (WHO) found that of the 82% of member states (158) countries, only 35% of the national cancer control plans addresses vulnerable population, including LGBT populations. These findings reflect an increasing awareness about equity when addressing cancer prevention and control, including LGBT populations. This book addresses LGBT populations’ cancer burden across countries that range from high- to low-income countries to support efforts in diverse countries that are working towards reducing LGBT populations’ cancer burden. It documents place-specific challenges that impede progress towards reducing the LGBT cancer burden as well as critically assesses the variation in cancer control efforts that target LGBT populations and cancer to support progress at a global scale. This book includes six sections that cover the six WHO regions, with each chapter written by an author from the specific region s/he is covering. Each chapter makes use of a template that contextualizes the region, local data collection/availability, risk factors, cancer prevention, detection, diagnosis, treatment, and survivorship.
    Type of Medium: Online Resource
    Pages: X, 335 p. 3 illus., 2 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031065859
    URL: https://doi.org/10.1007/978-3-031-06585-9
    DOI: 10.1007/978-3-031-06585-9
    DDC: 610.72
    Language: English
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  • 3
    Online Resource
    Online Resource
    Druggable Lipid Signaling Pathways (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Medical genetics. ; Cancer. ; Lipids. ; Biomedical Research. ; Pharmacology. ; Medical Genetics. ; Cancer Biology. ; Lipidology.
    Description / Table of Contents: Preface -- Introduction of Druggable Lipid Signaling Pathway -- Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Development -- Druggable Prostanoid Pathway -- Targeting Leukotrienes as a Therapeutic Strategy to Prevent Comorbidities Associated with Metabolic Stress -- Epoxy Fatty Acids are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation -- Druggable Sphingolipid Pathway -- Druggable Lysophospholipid Pathway -- Druggable targets in endocannabinoid signaling -- Drugging the phosphoinositide 3-kinase (PI3K) and phosphatidylinositol 4-kinase (PI4K) family of enzymes for treatment of cancer, immune disorders, and viral/parasitic infections -- Druggable Lipid GPCRs: Past, Present, and Prospects. .
    Abstract: This edited work presents a series of reviews focusing on Druggable Lipid Signaling Pathways. It enables researchers in both academic institutions and industry as well as physicians to understand historical aspects of lipid signaling and future directions of drug discovery targeting lipid signaling pathways. This book provides 9 pathways including acyltransferases, prostanoids, leukotrienes, epoxy fatty acids, sphingolipids, lysophospholipids, endocannabinoids, phosphoinositides, and lipid GPCRs. Readers will discover the importance of each lipid signaling pathway that contributes to broad range of diseases including neurological and neuropsychiatric diseases, pain, metabolic syndromes, cardiovascular diseases, cancer, dermatological diseases, fibrosis, inflammation, etc. Also, readers will recognize that many drugs targeting lipid signaling have been clinically used. Drugs currently under development are also discussed in each chapter, which includes some information about clinical trials and strategic drug designs. .
    Type of Medium: Online Resource
    Pages: VI, 260 p. 33 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030506216
    Series Statement: Advances in Experimental Medicine and Biology, 1274
    URL: https://doi.org/10.1007/978-3-030-50621-6
    DOI: 10.1007/978-3-030-50621-6
    DDC: 610.72
    Language: English
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  • 4
    Online Resource
    Online Resource
    Essentials of Tissue and Cells Banking (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Internal medicine. ; Hematology. ; Biomedical Research. ; Cell Biology. ; Internal Medicine. ; Hematology.
    Description / Table of Contents: Live Donors of Tissue -- Deceased Tissue Donors -- Banking and Use of Umbilical Cord Blood -- Ocular tissue banking -- Banking of Heart Valves -- Cryopreservation and Banking of Haematopoietic Progenitor Cells -- Storage, Processing and Preservation -- Cryopreservation in tissue banking -- Sterilisation by Irradiation -- Screening the tissue donor for infectious agents -- Contamination in the Tissue Way -- Establishing a Quality System in a Tissue Establishment -- IT System requirements for Tissue and Cell Banking -- Ethical and Regulatory Aspects of Cell and Tissue Banking -- Human embryonic stem cell banking for clinical applications – 20 years from their isolation.
    Abstract: It has been 10 years since the first edition of ‘Essentials of Tissue Banking’ has been published. There is still relatively little published on the technical and scientific principles on routine tissue and cell banking based on scientific principles. The 1st edition was very successful and, after a 10 year gap, there is a need of an update and an expansion of the book’s remit. The format of the book follows that of the previous edition- split into 5 sections. Management of donors and the banking of common tissues and cells; Principles of storage and processing of tissues and cells; Ensuring the safety of the products by testing the donor, the tissues and the environment, supported by a quality system and an IT infrastructure- all working within the constraints of current regulatory and ethical environments. This edition however provides a significant update. Many the chapters have been completely rewritten by different experts. Like the 1st edition, they were given a free hand in the way they wrote their chapter, with a guideline that they had to be concise, clear and up to date. The authors were also asked to provide the scientific and technical basis that provides the rationale of the processes they describe. Also, the scope of the book has been somewhat extended. In view of the fact that many cellular therapies are now routinely practiced, 2 new chapters have been added: one on the banking of haematopoietic stem cells and one on human embryonic stem cells. They have been deliberately chosen to illustrate the extreme spectrum of cellular therapies from one of the simplest to one of the most complex. The intention of the book has remained the same: to cover and update banking of current practices in essential tissue and cell banking. It is therefore hoped that by keeping the book as concise and up to date as possible, it will find a place on the shelves of many tissue establishments.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 48 illus., 28 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030716219
    URL: https://doi.org/10.1007/978-3-030-71621-9
    DOI: 10.1007/978-3-030-71621-9
    DDC: 610.72
    Language: English
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  • 5
    Online Resource
    Online Resource
    Mechanisms of Gene Regulation: How Science Works (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Biochemistry. ; Genetics. ; Biomedical Research. ; Biochemistry. ; Genetics and Genomics.
    Description / Table of Contents: Central dogma of molecular biology -- Impact of chromatin structure -- Epigenetics enables gene expression -- Gene regulation in the context of nuclear architecture -- Core promoter -- TATA box and other core promoter elements -- Genome-wide core promoter identification -- TFIID and Mediator as paradigms of multi-protein complexes -- Site-specific transcription factors and their domains -- Classification of transcription factors -- Activation of transcription factors -- Programing cellular differentiation by transcription factors -- Inflammatory signaling via NF-KB -- Sensing cellular stress via p53 -- The nuclear receptor superfamily -- Molecular interactions of nuclear receptors -- Physiological role of nuclear receptors -- Next-generation sequencing -- Gene regulation in the context of Big Biology -- Exploring genome-wide transcription factor binding -- Integrating epigenome-wide datasets -- Cytosines and their methylation -- Histone modifications -- Gene regulation via chromatin modifiers -- Sensing energy metabolism via chromatin modifiers -- Epigenetics and chromatin -- Genome-wide understanding of epigenetics -- CTCF and genetic imprinting -- Epigenetics in health and disease -- Nucleosome positioning at promoters -- Chromatin remodeling -- Transcriptional dynamics in the presence of chromatin -- Organization of the nucleus -- Non-coding RNAs -- miRNAs and their regulatory potential -- Long ncRNAs -- Enhancer RNAs.
    Abstract: This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.
    Type of Medium: Online Resource
    Pages: XVI, 149 p. 71 illus., 70 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030523213
    URL: https://doi.org/10.1007/978-3-030-52321-3
    DOI: 10.1007/978-3-030-52321-3
    DDC: 610.72
    Language: English
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  • 6
    Online Resource
    Online Resource
    Coenzyme Q in Aging (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Internal medicine. ; Biochemistry. ; Physiology. ; Biomedical Research. ; Cell Biology. ; Internal Medicine. ; Biochemistry. ; Physiology.
    Description / Table of Contents: Preface -- Part 1 Basics on coenzyme Q -- Introduction. The current coenzyme Q science and knowledge -- Molecular structure, biosynthesis, and distribution of coenzyme Q -- Coenzyme Q function in mitochondria -- Extramitochondrial coenzyme Q10 in aging -- Regulation of the synthesis of Coenzyme Q10 -- Part 2 Coenzyme Q in aging studies -- Coenzyme Q and aging in C. elegans -- Coenzyme Q and aging in the fruit fly Drosophila melanogaster -- The aging process and coenzyme Q: clk-1 mouse models -- Reduced coenzyme Q10 decelerates senescence and age-related hearing loss in senescence-accelerated mice by activating mitochondrial functions -- Part 3 Age-related diseases and coenzyme Q -- Coenzyme Q, mtDNA and mitochondrial dysfunction during aging -- Coenzyme Q10 and metabolic syndrome -- Coenzyme Q and age-related neurodegenerative disorders: Parkinson and Alzheimer diseases -- Immunosenescence and CoQ10 -- Coenzyme Q10 in fertility and reproduction -- Part 4 Prolongevity effectors and Coenzyme Q -- Calorie restriction, longevity and coenzyme Q -- Age dependent changes of coenzyme Q levels and its induction in experimental systems -- Effects of coenzyme Q10 supplementation on elderly people -- Index.
    Abstract: This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging. The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants. The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice. Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction. The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation. Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.
    Type of Medium: Online Resource
    Pages: XII, 369 p. 50 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030456429
    URL: https://doi.org/10.1007/978-3-030-45642-9
    DOI: 10.1007/978-3-030-45642-9
    DDC: 610.72
    Language: English
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  • 7
    Online Resource
    Online Resource
    Microbiological Advancements for Higher Altitude Agro-Ecosystems & Sustainability (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Microbial ecology. ; Biotic communities. ; Agriculture. ; Industrial microbiology. ; Biomedical Research. ; Microbial Ecology. ; Ecosystems. ; Agriculture. ; Industrial Microbiology.
    Abstract: The book explores the challenges and opportunities associated with high-altitude agro-ecosystems and the factors that influence them. It discusses the various indigenous agricultural practices and approaches, as well as the microbiology of mountain & hill agro-ecosystems, providing a comprehensive overview of the various factors that control the microbiome at high altitudes. The contributions examine microbiological advances, such as use of “omics” technologies for hill agriculture and environmental sustainability, and explore the use of nanotechnology for agricultural and environmental sustainability at higher altitudes. The book also describes various aspects of low-temperature microbiology in the context of high-altitude farming and environmental sustainability.
    Type of Medium: Online Resource
    Pages: XIII, 491 p. 62 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811519024
    Series Statement: Rhizosphere Biology,
    URL: https://doi.org/10.1007/978-981-15-1902-4
    DOI: 10.1007/978-981-15-1902-4
    DDC: 610.72
    Language: English
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  • 8
    Online Resource
    Online Resource
    Molecular Mechanisms in Spermatogenesis (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Reproductive health. ; Cytology. ; Biomedical Research. ; Reproductive Medicine. ; Cell Biology.
    Description / Table of Contents: Ch 1: The seminiferous epithelial cycle of spermatogenesis: Role of non-receptor protein kinases -- Ch 2: Sertoli cells: immunology and spermatogenesis -- Ch 3: Innate immunity and spermatogenesis -- Ch 4: Cell apoptosis and spermatogenesis -- Ch 5: Transcriptional regulation of spermatogenesis -- Ch 6: Sertoli cell cytoskeleton and spermatogenesis -- Ch 7: Leydig cell and spermatogenesis -- Ch 8: Cross-talk of cell junctions to support spermatogenesis -- Ch 9: Coordination of F-actin- and MT-based cytoskeletons to support spermatogenesis -- Ch 10: Regulation of the blood-testis barrier by basement membrane laminin-α2 chain -- Ch 11: Regulation of spermatogenesis by collagens -- Ch 12: Androgen regulation of spermatogenesis -- Ch 13: Use of molecular modeling to study spermatogenesis -- Ch 14: Acrosome biogenesis during spermatogenesis -- Ch 15: Stem cells and spermatogenesis -- Ch 16: Advances in our understanding of spermatogenesis in humans -- Ch 17: Leydig cell function in aging men -- Ch 18: Regulation of human spermatogenesis.
    Abstract: This new edition provides an update on the molecular mechanisms that regulate spermatogenesis. In addition to the rodent as a study model, chapters also include research on studies in humans. It includes the latest approaches of studying spermatogenesis, such as the use of bioinformatics, molecular modeling and others which are not commonly found in published materials. It also reviews the latest developments in the field, such as studies on the role of regulatory RNAs on spermatogenesis. Due to the declining fertility rate among men, a brand new chapter highlights the impact of environmental toxicants on spermatogenesis.
    Type of Medium: Online Resource
    Pages: X, 319 p. 44 illus., 40 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030777791
    Series Statement: Advances in Experimental Medicine and Biology, 1381
    URL: https://doi.org/10.1007/978-3-030-77779-1
    DOI: 10.1007/978-3-030-77779-1
    DDC: 610.72
    Language: English
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  • 9
    Online Resource
    Online Resource
    The Renin Angiotensin System in Cardiovascular Disease (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cardiovascular system. ; Physiology. ; Cardiology. ; Clinical biochemistry. ; Biomedical Research. ; Cardiovascular Physiology. ; Cardiology. ; Medical Biochemistry.
    Description / Table of Contents: Past, present and future perspectives of renin angiotensin system -- Biochemical pathways of renin angiotensin system -- Structure-function relationships of angiotensin II receptors -- Signal transduction mechanism of angiotensin II -- Renin angiotensin system: Pathophysiology and clinical implications in cardiovascular disease COVID-19 infection -- Angiotensin II and the pathogenesis of hypertension -- Signaling transduction of angiotensin II in hypertension -- Role of angiotensin II type 1 receptors in vascular remodeling in hypertension -- Molecular and cellular mechanisms of renin-angiotensin system in hypertension -- Tissue renin-angiotensin system and risks in hypertension -- Oxidative stress and angiotensin II-induced hypertension -- Angiotensin II: inflammatory system disorder and hypertension -- Therapeutic approaches for angiotensin receptor blockers in hypertension -- Renin-angiotensin systems: A pivotal role in the development of atherosclerosis -- Angiotensin II induced intracellular signaling pathways in pathogenesis of atherosclerosis -- Cellular and molecular mechanisms of Ang II: Contribution to atherosclerotic plaque vulnerability -- Role of angiotensin II, nitric oxide and reactive oxygen species in atherosclerosis -- The renin-angiotensin system and inflammatory processes in atherosclerotic lesion formation -- Role of renin-angiotensin system in alterations in blood lipids and gene expression in atherogenesis -- Effects of angiotensin-converting enzyme and receptors in atherosclerosis -- Effects of angiotensin II on cardiac arrhythmia and signal transduction -- Angiotensin II induced oxidative stress contribute to ventricular arrhythmias -- Modulation of renin angiotensin system: Beneficial effect on ventricular arrhythmias -- ACE inhibitor and ventricular arrhythmia in ischemic heart disease -- The renin-angiotensin system modulators and cardiac arrhythmias -- Angiotensin receptor blockers in the treatment of arrhythmias -- Angiotensin II induced cardiac hypertrophy and heart failure -- Renin-angiotensin system: Role in cardiac remodeling and subcellular defects in heart failure -- Renin-angiotensin system: Molecular and cellular mechanisms in heart failure -- Role of angiotensin II receptor mRNA expression in heart failure -- Renin angiotensin system: Mitochondrial dysfunction in the progression of heart failure -- Angiotensin II type 1 receptor: Genetic polymorphisms and heart failure -- Angiotensin converting enzyme 2 and angiotensin metabolism in heart failure -- Cellular and molecular mechanisms of renin-angiotensin system blockade in heart failure: An update -- Angiotensin II receptor antagonists: Modulation of the extracellular matrix regulatory system in heart failure.
    Abstract: This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.
    Type of Medium: Online Resource
    Pages: XVIII, 452 p. 71 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031149528
    Series Statement: Advances in Biochemistry in Health and Disease, 24
    URL: https://doi.org/10.1007/978-3-031-14952-8
    DOI: 10.1007/978-3-031-14952-8
    DDC: 610.72
    Language: English
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  • 10
    Online Resource
    Online Resource
    Molecular Mechanisms of Retina Pathology and Ways of its Correction (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Geriatrics. ; Ophthalmology. ; Pathology. ; Cytology. ; Pharmacy. ; Biomedical Research. ; Geriatrics. ; Ophthalmology. ; Pathology. ; Cell Biology. ; Pharmacy.
    Description / Table of Contents: Chapter 1. Literature review -- Chapter 2. Results of experimental studies of short peptides (cytogens) in ophthalmology -- Chapter 3. Results of the clinical study of short peptides (cytogens) in ophthalmology -- Conclusion.
    Abstract: This book discusses the pathology of the retina, and reviews current research on the use of cell replacement therapy and short peptides to restore functional activity in retinal neurons. As the book describes, pathologies of the retina, including age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, present a long-standing challenge in the practice of clinical ophthalmology. Modern treatment for these conditions, which lead to irreversible blindness, includes laser exposure, surgical intervention, and drugs. These treatments aim to reduce the risk of new complications in the eye; pathogenetic therapy of degenerative diseases of the retina is practically absent in current ophthalmic practice. The first section of the book reviews the molecular mechanisms of age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, and reports on methods of treatment. The second section presents the results of recent experimental studies of the effects of short peptides on pluripotent embryonic cells; on proliferative activity in retinal cells and pigment epithelium; on expression of markers of differentiation or retinal neurons and pigment epithelium; and on the course of hereditary retinal pigmentation in Campbell rats. The third section offers results of clinical studies on the effectiveness of short peptides in patients with macular degeneration, and in patients with retinitis pigmentosa. The author concludes that the regular use of peptides in the treatment of degenerative diseases of the retina can slow the progression of the pathological process and preserve the patient’s vision for some 10-15 years. In addition, in 80 percent of patients, it is possible to increase visual function by increasing visual acuity, improving the boundaries of the visual field and the fundus.
    Type of Medium: Online Resource
    Pages: VI, 90 p. 17 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030501600
    URL: https://doi.org/10.1007/978-3-030-50160-0
    DOI: 10.1007/978-3-030-50160-0
    DDC: 610.72
    Language: English
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  • 11
    Online Resource
    Online Resource
    Autophagy: Biology and Diseases : Clinical Science (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Medical sciences. ; Pharmacology. ; Biomedical Research. ; Cell Biology. ; Health Sciences. ; Pharmacology.
    Description / Table of Contents: Autophagy and Alzheimer’s Disease -- Autophagy and Parkinson’s Disease -- Autophagy and Motor Neuron Diseases -- Autophagy and Prion Disease -- Autophagy and Lysosome Storage Disorders -- Autophagy and Mitochondrial Encephalomyopathies -- Autophagy and Ischemic Stroke -- Autophagy and Hemorrhagic Stroke -- Autophagy and Polyglutamine Disease -- Autophagy and Epilepsy -- Autophagy in Neurodevelopmental Disorders -- Autophagy and Pituitary Adenoma -- Autophagy in Schizophrenia -- Autophagy and Hypertension -- Autophagy and Myocardial Ischemia -- Autophagy and Heart Failure -- Autophagy, Myocarditis and Cardiomyopathy -- Autophagy, Hyperlipidemia and Atherosclerosis -- Application of Autophagy in Cardiovascular Diseases -- Autophagy and Tumorigenesis -- Autophagy and Tumour Stem Cells -- Autophagy and Tumour Metastasis -- Autophagy and Tumor Cell Death -- Autophagy and Tumour Chemotherapy -- Autophagy and Tumour Radiotherapy -- Autophagy and Inflammatory Diseases -- Autophagy and Immune-related Diseases -- Autophagy and Autoimmune Diseases -- Autophagy and Bacterial Infection -- Autophagy and Viral Infection -- Autophagy and Thyroid Disease -- Autophagy and Obesity and Diabetes -- Autophagy and Obesity-related Reproductive Dysfunction -- Autophagy and Acute Kidney Injury -- Autophagy and Glomerular Diseases -- Autophagy and Diabetic Nephropathy -- Autophagy and Liver Diseases -- Autophagy and Gastrointestinal Diseases -- Chronic Obstructive Pulmonary Disease and Autophagy -- Autophagy and Pulmonary Fibrosis -- Asthma and Autophagy -- Autophagy and Other respiratory diseases -- Autophagy and Leukemia -- Autophagy and Lymphoma -- Autophagy and Myeloma -- The Function and Mechanisms of Autophagy in Traumatic Brain Injury -- The Function and Mechanisms of Autophagy in Spinal Cord Injury -- The Function and Mechanisms of Autophagy in Trauma of Other Parts of the Body -- The Prospects of Therapeutic Potential and Drug Development Targeting Autophagy in Cancer -- Progress of Anti-aging Drugs Targeting Autophagy -- Drug Development and Treatment of Autophagy in Other Diseases -- Systems Biology Approaches in Autophagy Research -- Natural Product Regulates Autophagy in Cancer -- Regulation of Autophagy in Neurodegenerative Diseases by Natural Products -- Regulation of Autophagy in Cardiovascular Diseases by Natural Products.
    Abstract: This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine.
    Type of Medium: Online Resource
    Pages: XXXVI, 736 p. 50 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811542725
    Series Statement: Advances in Experimental Medicine and Biology, 1207
    URL: https://doi.org/10.1007/978-981-15-4272-5
    DOI: 10.1007/978-981-15-4272-5
    DDC: 610.72
    Language: English
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  • 12
    Online Resource
    Online Resource
    Explaining Health Across the Sciences (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medicine Philosophy. ; Medical sciences. ; Science Philosophy. ; Biomedical Research. ; Philosophy of Medicine. ; Health Sciences. ; Philosophy of Science.
    Abstract: This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final part looks at more clinical or practical perspectives. It thereby gathers, across 30 chapters, diverse perspectives from the broad fields of evolutionary and systems biology, immunology, and biogerontology, more specific areas such as odontology, cardiology, neurology, and public health, as well as philosophical reflections on mental health, sexuality, authenticity and medical theories. The overarching aim is to inform, inspire and encourage intellectuals from various disciplines to assess whether explanations in these disparate fields and across biological levels can be sufficiently systematized and unified to clarify the complexity of health. It will be particularly useful for medical graduates, philosophy graduates and research professionals in the life sciences and general medicine, as well as for upper-level graduate philosophy of science students.
    Type of Medium: Online Resource
    Pages: XVII, 555 p. 30 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030526634
    Series Statement: Healthy Ageing and Longevity, 12
    URL: https://doi.org/10.1007/978-3-030-52663-4
    DOI: 10.1007/978-3-030-52663-4
    DDC: 610.72
    Language: English
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  • 13
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    Online Resource
    Genome Editing in Cardiovascular and Metabolic Diseases (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Metabolism Disorders. ; Genetics. ; Cardiovascular system. ; Physiology. ; Biomedical Research. ; Metabolic Disease. ; Genetics and Genomics. ; Cardiovascular Physiology.
    Description / Table of Contents: An overview of genome editing in cardiovascular and metabolic diseases -- Bioinformatics research methodology of genome editing in cardiovascular and metabolic diseases -- Online databases of genome editing in cardiovascular and metabolic diseases -- Application of systems biology for genome editing involved in regulating of cardiovascular and metabolic diseases -- Bioinformatics for reducing off-targets in cardiovascular and metabolic diseases -- Genome editing and cardiac regeneration -- Genome editing and myocardial development -- Genome editing and heart failure -- Genome editing and pathological cardiac hypertrophy -- Genome editing and cardiac remodeling -- Genome editing and diabetic cardiomyopathy -- Genome editing and cardiac arrhythmias -- Genome editing and atrial fibrillation -- Genome editing and muscle atrophy -- Genome editing and obesity -- Genome editing and fatty liver -- Genome editing and diabetes -- Genome editing and gout -- Genome editing and protein energy malnutrition -- Genome therapy and cardiovascular diseases -- Therapeutics in metabolic diseases -- Gene editing and human iPSCs in cardiovascular and editing diseases -- Prospective advances in genome editing investigation.
    Abstract: This book provides the latest research progress on genome editing in cardiovascular and metabolic diseases and includes bioinformatics research methodology of genome editing. Genome editing is a genetic engineering technique precisely modified specific target genes of organism genome, which has been applied to basic theoretical research and production applications from plants and animals to gene therapy of human beings. Cardiovascular and metabolic diseases have become major factors affecting human health worldwide. This book contains information about bioinformatics, genome editing in cardiovascular diseases, genome editing in metabolic diseases and therapeutic effects. It will be useful for biologist, cardiologist, cardiovascular surgeons, endocrinologist, internists, nurses, undergraduate and graduate students in medicine and cell biology and others interested in cardiovascular and metabolic medicine.
    Type of Medium: Online Resource
    Pages: XII, 339 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811956423
    Series Statement: Advances in Experimental Medicine and Biology, 1396
    URL: https://doi.org/10.1007/978-981-19-5642-3
    DOI: 10.1007/978-981-19-5642-3
    DDC: 610.72
    Language: English
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  • 14
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    Online Resource
    Salivary Bioscience : Foundations of Interdisciplinary Saliva Research and Applications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Biochemistry. ; Psychology. ; Dentistry. ; Endocrinology. ; Biomedical Research. ; Medical Biochemistry. ; Biochemistry. ; Behavioral Sciences and Psychology. ; Dentistry. ; Endocrinology.
    Description / Table of Contents: Part 1: What is Salivary Bioscience, Why is it Important, and How Do We Study It? -- Chapter 1: Foundations of Interdisciplinary Salivary Bioscience: An Introduction (Granger et al.) -- Chapter 2: Salivary Gland Anatomy and Physiology (Hernández et al.) -- Chapter 3: Saliva Collection, Handing, Transport, and Storage: Special Considerations and Best Practices for Interdisciplinary Salivary Bioscience(Padilla et al.) -- Chapter 4: Analytical Strategies and Tactics in Salivary Bioscience (Riis et al.) -- Part 2: Physiology and Development Research and Applications (Part 2 Editor: Dr. Jenna Riis) -- Chapter 5: Salivary Bioscience, Human Stress, and the Hypothalamic Pituitary Adrenal Axis (Clow et al.) -- Chapter 6: The Use of Saliva for Genetics and Epigenetics Research (Nemoda et al.) -- Chapter 7: Saliva as a Window Into the Human Oral Microbiome and Metabolome(Whiteson et al.) -- Chapter 8: Salivaomics, saliva Exo-somics, and Saliva Liquid Biopsy (Wong et al.) -- Chapter 9: Salivary Bioscience, Immunity, and Inflammation (Riis et al.) -- Chapter 10:Salivary Bioscience and Human Development (Hibel et al.) -- Part 3: Biomedical Research and Related Applications (Part 3 Editor: Dr. Elizabeth Thomas) -- Chapter 11: Biomedical Research and Related Applications:Current Assay Methods and Quality Requirements in Oral Fluid Diagnostics Applications (Granger S. et al.) -- Chapter 12: Salivary Biomarkers and Neurodegenerative Conditions (Thomas et al.) -- Chapter 13: The Use of Antibodies in Saliva to Measure PathogenExposure and Infection(Heaney et al.) -- Chapter 14: Salivary Bioscience and Pain (Payne et al.) -- Chapter 15: Salivary Bioscience and Environmental Exposure Assessment (Panuwet et al.) -- Chapter 16: Saliva and Drugs of Abuse (Navazesh et al.) -- Chapter 17: Therapeutic Drug Monitoring in Saliva (Thomas) -- Chapter 18: Salivary Bioscience and Periodontal Medicine (Freire et al.) -- Chapter 19: Salivary Bioscience and Cancer (Navazesh et al.) -- Part 4: Psychosocial Research and Applications(Part 4 Editor: Dr. Kate Ryan Kuhlman) -- Chapter 20: Salivary Bioscience in Clinical Psychologyand Psychiatry(Kuhlman) -- Chapter 21: Salivary Bioscience Research in Health Psychology and Behavioral Medicine (Hoyt et al.) -- chapter 22: The Neuroscience of Human Social Behavior: A Review of How Testosterone and Cortisol Underpin Competition and Affiliation Dynamics (Kornienko et al.) -- chapter 23: Salivary Studies of the Social Neuroscience of Human-animal Interaction (Pendry et al.) -- Part 5: Population Health Research and Applications(Part 5 Editor: Dr. Marcus Taylor) -- Chapter 24: Salivary Bioscience and Military, Space, and OperationalResearch(Roma et al.) -- Chapter 25: Salivary Bioscience Research Related to Prenatal Adversity (Eiden et al.) -- Chapter 26: Salivary Bioscience and Pediatrics (Johnson et al.) -- Chapter 27: Use of saliva to better understand the experience of adulthood and aging(Almeida et al.) -- Chapter 28: Salivary Bioscience and Research on Animal Welfare and Conservation Science(Staley et al.) -- Part 6: The Way Forward: Future Directions for the Science and Practice of Salivary Bioscience -- Chapter 29:Applications of Salivary Bioscience to Precision Medicine (Kuhlman) -- Chapter 30:Public Health and IndustryApplications of Salivary Bioscience (Riis et al.) -- Chapter 31: Envisioning the Future of Interdisciplinary Salivary Bioscience (Granger et al.).
    Abstract: This book provides the first comprehensive overview of the emerging field of interdisciplinary salivary bioscience. It serves as a foundational reference guide to the collection, analysis, and interpretation of salivary data, as well as its myriad applications in medicine, surveillance and public health. The ease and non-invasive nature of saliva collection makes it highly useful in diverse fields such as pediatrics, dentistry, neuroscience, psychology, animal welfare and precision medicine. This book introduces students and scientists alike to the vast potential of salivary bioscience in both research and practice.
    Type of Medium: Online Resource
    Pages: XIV, 751 p. 56 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030357849
    URL: https://doi.org/10.1007/978-3-030-35784-9
    DOI: 10.1007/978-3-030-35784-9
    DDC: 610.72
    Language: English
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  • 15
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    Online Resource
    Periodontitis : Advances in Experimental Research (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical microbiology. ; Parasitology. ; Biomedical Research. ; Medical Microbiology. ; Parasitology.
    Description / Table of Contents: Preface -- Chapter1. Advances in experimental research about periodontitis: lessons from the past, ideas for the future (Julien Santi-Rocca) -- Part I: Periodontal microbiota -- Chapter 2. Microbiota in Periodontitis: advances in the omic era (Shao Bing Fong, Emile Boyer, Martine Bonnaure-Mallet, Vincent Meuric) -- Chapter 3. Aggregatibacter actinomycetemcomitans: from basic to advanced research (Abdelhadi Hbibi, Amal Bouziane, Badiaa Lyoussi, Mimoun Zouhdi, Driss Benazza) -- Chapter 4. Meta-analyses on the Periodontal Archaeome (Jéssica Alves de Cena, Yuri Silvestre-Barbosa, Aline Belmok, Cristine Miron Stefani, Cynthia Maria Kyaw, Nailê Damé-Teixeira) -- Chapter 5. Parasites in periodontal health and disease: a systematic review and meta-analysis (David Felipe Martin-Garcia, Malik Sallam, Gabriela Garcia, Julien Santi-Rocca) -- Chapter 6. Fungi - a component of the oral microbiome involved in periodontal diseases (Justyna Karkowska-Kuleta, Dorota Satala, Magdalena Smolarz, Marcin Zawrotniak, Maria Rapala-Kozik) -- Chapter 7. Herpesviruses in periodontitis: An umbrella review (Aleksandar Jakovljevic, Miroslav Andric, Jelena Jacimovic, Jelena Milasin, Javier Enrique Botero) -- Part II: Periodontitis pathophysiology -- Chapter 8. Recent updates on microbial biofilms in periodontitis: an analysis of in vitro biofilm models (Maick Meneguzzo Prado, Nathalia Figueiredo, Andréa Pimenta, Tamires Szeremeske Miranda, Magda Feres, Luciene Cristina Figueiredo, Josiane de Almeida, Bruno Bueno-Silva) -- Chapter 9. Update on B cell response in periodontitis (Julien Demoersman, Jacques Olivier Pers) -- Chapter 10. Polarization profiles of T lymphocytes and macrophages responses in periodontitis (Franco Cavalla, Marcela Hernández) -- Chapter 11. Complementary experimental methods in genetics open up new avenues of research to elucidate the pathogenesis of periodontitis (Arne S. Schaefer) -- Part III: Periodontitis-associated conditions -- Chapter 12. Update on the bidirectional link between diabetes and periodontitis (Leila Salhi, Michèle Reners) -- Chapter 13. Periodontitis as a risk factor for Alzheimer’s disease: the experimental journey so far, with hope of therapy (Alice Harding, Shalini Kanagasingam, Richard Welbury, Sim K. Singhrao) -- Chapter 14. Cardiovascular diseases and periodontitis (Peter Riis Hansen, Palle Holmstrup) -- Part IV: Therapeutic management of periodontitis -- Chapter 15. Update on the role of cytokines as oral biomarkers in the diagnosis of periodontitis (Triana Blanco-Pintos, Alba Regueira-Iglesias, Carlos Balsa-Castro, Inmaculada Tomás) -- Chapter 16. Non-surgical periodontal treatment: SRP and innovative therapeutic approaches (Alexia Vinel, Antoine Al Halabi, Sébastien Roumi, Hélène Le Neindre, Pierre Millavet, Marion Simon, Constance Cuny, Jean-Sébastien Barthet, Pierre Barthet, Sara Laurencin-Dalicieux) -- Chapter 17. Update on the roles of oral hygiene and plaque control on periodontal disease (Leila Salhi, Bruno De Carvalho, Michèle Reners) -- Chapter 18. Multi-photonic adjunctive therapy for the management of periodontitis: recent advances and new treatment approach (Marco Giannelli, Daniele Bani) -- Chapter 19. Probiotics during the therapeutic management of periodontitis (Flavia Furlaneto, Karin Hitomi Ishikawa, Michel Reis Messora, Marcia P A Mayer) -- Chapter 20. Periodontal cell therapy: a systematic review and meta-analysis (Antoine Dubuc, Valérie Planat-Bénard, Mathieu Marty, Paul Monsarrat, Philippe Kémoun) -- Index.
    Abstract: Periodontitis is a disease that affects more than half the adult population in the world. Treatment is often based on ancient recommendations consisting in mechanically removing material from damaged zones. However, novel therapeutic management strategies exist, from prevention to efficient treatment, and regeneration. The need of integrative approaches to circumvent this worldwide pledge can be achieved through: A better understanding of this complex disease by promoting scientific research and a comprehensive multidisciplinary approach, including epidemiology, microbiology, immunology, physiology, therapeutics, psychology, etc. A better outreach by promoting vulgarization and recommendations for health professionals. A better information of the empowered patients, leading them to consider prevention and to take part in their therapeutic course. The book “Periodontitis: Advances in Experimental Research” includes a timely collection of chapters covering all the fields of research about periodontitis, consisting in concise reviews by the best specialists themselves and with clinical perspectives for periodontitis. Recent technological advances have allowed to explore shadowed areas of periodontology. The book “Periodontitis: Advances in Experimental Research” is a unique occasion to set a milestone for a more integrated field of periodontitis, with a broad scientific, medical, and public audience thanks to dedicated sections in each chapter: Abstract and main body (scientific audience and expert clinicians) Highlights (scientific audience and clinicians) Impact for Practice (clinicians and economical/political decision makers) Summary for Patients (patients and economical/political decision makers).
    Type of Medium: Online Resource
    Pages: XIII, 402 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030968816
    Series Statement: Advances in Experimental Medicine and Biology, 1373
    URL: https://doi.org/10.1007/978-3-030-96881-6
    DOI: 10.1007/978-3-030-96881-6
    DDC: 610.72
    Language: English
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  • 16
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    Online Resource
    Biomedical Translational Research : Technologies for Improving Healthcare (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cancer. ; Technology Sociological aspects. ; Genomics. ; Biomedical Research. ; Cancer Biology. ; Emerging Technologies. ; Genomics.
    Description / Table of Contents: Chapter 1. Introduction to emerging technologies in biomedical sciences -- Chapter 2. Bioprospecting : boon or curse -- Chapter 3. Growing need for interdisciplinary biomedical research -- Chapter 4. Interplay between theory and experiment : a future approach for biomedical research -- Chapter 5.past, present and future perspectives of biomedical innovation in india -- Chapter 6. Systems biology approaches to study disease comorbidities -- Chapter 7. Bioinformatics the interactome of multidisciplinary approaches -- Chapter 8. Role of artificial intelligence in diagnosis of infectious diseases -- Chapter 9. Dna digital data storage breakthroughs in biomedical research. Chapter 10. Biomedical applications cloud-based iot -- Chapter 11. Next generation sequencing in cancer research -- Chapter 12. Crispr: genome editing and beyond -- Chapter 13. Omics in tuberculosis diagnosis : today and tomorrow -- Chapter 14. Advances in proteomic approaches for chronic kidney disease -- Chapter 15. 3 d bioprinting of tissues and organs : a new paradigm in regenerative medicine and biomedical engineering -- Chapter 16. Virtual planning, rapid prototyping and 3-d printing in orthopedic surgery -- Chapter 17. Tissue chips: contemporary applications and advancementstissue chips: contemporary applications and advancements -- Chapter 18. Flow cytometry for measuring neutrophil function -- Chapter 19. Flow cytometer for understanding genome size variation among medicinal herbs and non-edible oil trees of northeast india -- Chapter 20. Raman spectroscopy applications for bacterial detection -- Chapter 21. Microfluidic point-of-care diagnostic devices: a contemporary relevance. Chapter 22. Fluorescent dots for breast cancer management -- Chapter 23. Molecular mimicry : unravelling the role of autoantibodies in autoimmune diseases and infertility -- Chapter 24. Strategies of vaccine development -- Chapter 25. Preclinical models of intimal hyperplasia and restenosis to predict clinical events and develop novel therapies -- Chapter 26. Sphingolipids : a roadmap from biomarker identification to clinical application -- Chapter 27. Future of gastrointestinal endoscopy -- Chapter 28. Beating heart in a box : the future of cardiac transplant -- Chapter 29. The journey of coronary stent technology -- Chapter 30. Materiovigilance in clinical surgery.
    Abstract: This book, which is the first volume of Biomedical Translational Research, summarizes emerging technologies in healthcare. The book reviews the advancements in biomedical sciences in genomics, immunology, stem cell, tissue engineering, nanotechnology, computational and structural biology, biomedical engineering, and telemedicine biology. The book highlights the applications of artificial intelligence in the diagnosis of infectious diseases and examines the role of system biology approaches for understanding human complexity, variability, and its influence on health and diseases. It presents the applications of flow cytometry in monitoring the progression and treatment of disease. It covers emerging technologies in cancer research, including CRISPR-Cas9, NGS, and nanotechnology. This book is a useful source of information for clinical researchers, basic scientists, biomedical engineers, and computational biologists.
    Type of Medium: Online Resource
    Pages: XIII, 505 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811643453
    URL: https://doi.org/10.1007/978-981-16-4345-3
    DOI: 10.1007/978-981-16-4345-3
    DDC: 610.72
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  • 17
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    Online Resource
    Microbes and Oral Squamous Cell Carcinoma : A Network Spanning Infection and Inflammation (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical microbiology. ; Microbial genetics. ; Industrial microbiology. ; Microbiology. ; Biomedical Research. ; Medical Microbiology. ; Microbial Genetics. ; Industrial Microbiology. ; Microbiology.
    Description / Table of Contents: Chapter 1. Epidemiology of Oral Squamous Cell Carcinoma in Indian Scenario -- Chapter 2. Risk factors for Oral Squamous Cell Carcinoma in the Indian population -- Chapter 3. Molecular Carcinopathogenesis in Oral Squamous Cell Carcinoma -- Chapter 4. Inflammation and Infection in Cancer -- Chapter 5. Role of Inflammation and Infection in Oral Squamous Cell Carcinoma -- Chapter 6. Normal Microbiome of Oral cavity -- Chapter 7. Oral Microbiome in Oral Squamous Cell Carcinoma -- Chapter 8. Microbial Dysbiosis in Oral Squamous Cell Carcinoma -- Chapter 9. Bacteria induced carcinopathogenesis in Oral Squamous Cell Carcinoma -- Chapter 10. Virus induced carcinopathogenesis in Oral Squamous Cell Carcinoma -- Chapter 11. Fungi: Culprits or Bystanders in Oral Squamous Cell Carcinoma -- Chapter 12. Microbial ‘omics’ in Oral Squamous Cell Carcinoma -- Chapter 13. Implications and Future perspectives.
    Abstract: This book helps in understanding the relationship between microorganisms and oral carcinogenesis, and the possible oncogenic mechanisms enhancing the association. The book highlights the association between oral cancer, primarily oral squamous cell carcinoma (OSCC), a major global health problem with high incidence and low survival rates with infection and inflammation. Establishing the association of the oral microbiome with cancer risk may lead to significant advances in the understanding cancer etiology, potentially opening a new research paradigm for cancer prevention. The book takes the readers through interesting topics such as the epidemiology and etiology of OSCC, the hallmarks of cancer, and the role of inflammation in OCSS. It presents the difference between the normal and diseased oral microbiome. It further describes the carcino-pathogenesis of various groups. Finally, it discusses the clinical correlation of the observations and what the future looks like for this area of research. The book is interesting for medical students, researchers and clinicians, alike. The knowledge from the book can be exploited practically and used for designing further experiments.
    Type of Medium: Online Resource
    Pages: XIII, 172 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811905926
    URL: https://doi.org/10.1007/978-981-19-0592-6
    DOI: 10.1007/978-981-19-0592-6
    DDC: 610.72
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  • 18
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    Online Resource
    Biomedical Visualisation : Volume 14 ‒ COVID-19 Technology and Visualisation Adaptations for Biomedical Teaching (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical education. ; Anatomy. ; Virtual reality. ; Augmented reality. ; Biomedical Research. ; Medical Education. ; Anatomy. ; Virtual and Augmented Reality.
    Description / Table of Contents: Chapter 1. Pandemic-Era Digital Education: Insights from an Undergraduate Medical Programme -- Chapter 2. Use of Lt Systems in Large Class Lab Delivery -- Chapter 3. COVID-19 Adaptations for Biomedical Teaching and Assessment Within the Undergraduate Dental Curriculum -- Chapter 4. One Size Does Not Fit All in Remote Anatomy Teaching -- Chapter 5. From Lecture Halls to Zoom Links: How Can Educational Theory Help Us to Deliver Effective and Engaging Teaching in an Online Environment? -- Chapter 6. Collaborative, Two-Directional Live Streaming to Deliver Hands-on Dissection Experience during the COVID-19 Lockdown -- Chapter 7. Livestreaming Can Augment the Observation of Veterinary Post-mortem Examinations -- Chapter 8. Virtual Reality for Anatomy and Surgical Teaching -- Chapter 9. Can Synchronous Online Near-Peer Teaching Offer the Same Benefits as the Face-to-Face Version When Used in Clinical Neuroanatomy Education? -- Chapter 10. COVID-19 Adaptations with Virtual Microscopy -- Chapter 11. The Challenges of Visualisation During Delivery and Assessment of Clinical Teaching Under COVID-19: A Reflective Account of Problem Solving -- Chapter 12. Not for Room 101.
    Abstract: This book focuses on the challenges to biomedical education posed by the lockdowns and restrictions to on campus teaching brought about by the COVID-19 pandemic and highlights the tools and digital visualization technologies that have been successfully developed and used for remote teaching. Biomedical education for science, medical, dental and allied health professionals relies on teaching visual and tactile knowledge using practice-based approaches. This has been delivered for decades via on-campus lectures, workshops and laboratories, teaching practical skills as well as fundamental knowledge and understanding. However, the arrival of the COVID-19 pandemic meant that education across the globe had to pivot very quickly to be able to deliver these skills and knowledge in a predominantly online environment. This brought with it many challenges, as Higher Education staff, had to adapt to deliver these visual subjects remotely. This book addresses the challenges and solutions faced by Higher Education staff in teaching visual content in distance education. Chapters include literature reviews, original research, and pedagogical reflections for a wide range of biomedical subjects, degrees such as medicine, dentistry and veterinary sciences with examples from undergraduate and postgraduate settings. The goal of the book is to provide a compendium of expertise based on evidence gathered during the COVID-19 pandemic, as well as reflections on the challenges and lessons learned from this dramatic shift in teaching. It also presents new examples of best practices that have emerged from this experience to ensure that they are not lost as we return to on-campus learning in a new era of biomedical teaching. This book will be of interest to anyone looking for a helpful reference point when designing online or blended teaching for visual practice-based subjects.
    Type of Medium: Online Resource
    Pages: X, 228 p. 56 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031171352
    Series Statement: Advances in Experimental Medicine and Biology, 1397
    URL: https://doi.org/10.1007/978-3-031-17135-2
    DOI: 10.1007/978-3-031-17135-2
    DDC: 610.72
    Language: English
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  • 19
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    Online Resource
    Biological Effects of Static Magnetic Fields (2023)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Biomedical Research. ; Cell Biology.
    Description / Table of Contents: Chapter 1. Magnetic Field Parameters and Biological Sample Differences that Lead to Differential Bioeffects -- Chapter 2. Static Magnetic Field Direction-induced Differential Biological Effects -- Chapter 3. Magnetic Properties of Biological Samples -- Chapter 4. Molecular Mechanisms for Electromagnetic Field Biosensing -- Chapter 5. Controlling Cell Membrane Potential with Static Non-uniform Magnetic Fields -- Chapter 6. Impact of Static Magnetic Fields on Cells -- Chapter 7. Impact of Static Magnetic Fields on Microorganisms, Plants and Animals -- Chapter 8. Static Magnetic Fields on Human Bodies -- Chapter 9. Potential Applications of Static Magnetic Fields in Cancer Treatment -- Chapter 10. Effects of Static Magnetic Fields on Diabetes and Its Complications -- Chapter 11. Impacts of Static Magnetic Field on Bone Health -- Chapter 12. Effects of Static Magnetic Fields on the Immune System -- Chapter 13. Biological Effects of Static Magnetic Fields on the Nervous System -- Chapter 14. The Biological Effects of Long-term Static Magnetic Field Exposure -- Chapter 15. Prospects, Pitfalls, and Opportunities for Human Static Magnetic Field Therapy.
    Abstract: The book summarizes the emerging topic about the effects of SMF on biological samples ranging from single molecules, subcellular compartments, and cells to whole organisms. It also discusses the potential application of SMF in clinical treatment of cancer, pain, diabetes and other diseases. With the development and growing popularity of modern appliances like MRI in hospitals, the potential impact of magnetic fields on human health is invoking increasing concerns. At the same time, SMF has been explored in the treatment of tumor and other diseases for decades. Nevertheless, there are still some reservations and uncertainties about these treatments, which are largely due to the differential biological effects reported in the literature. These experimental inconsistencies are mainly caused by variations such as different magnetic field types, intensities, treatment time, as well as biological samples examined. The second edition added eight new chapters about new progress in this field including impacts of SMFs, magnetism of biomolecules, and potential of SMFs in the management of bone, pain, diabetes, and immune systems. This volume will help clarify some dilemmas in this field and encourage further investigations in order to achieve a better understanding of the biological effects of SMF, aiming for a rational application of SMF in clinical therapy in the near future. The book is useful for scientists, doctors, and students who are interested in magnetic fields and life sciences.
    Type of Medium: Online Resource
    Pages: XV, 420 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789811988691
    URL: https://doi.org/10.1007/978-981-19-8869-1
    DOI: 10.1007/978-981-19-8869-1
    DDC: 610.72
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  • 20
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    Online Resource
    Myosins : A Superfamily of Molecular Motors (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Proteins . ; Cytology. ; Proteins. ; Biomedical Research. ; Protein Biochemistry. ; Cell Biology. ; Proteins.
    Description / Table of Contents: Introduction -- Myosin Structure -- Cargo Binding by Unconventional Myosins -- Cryo-EM of Actin-Myosin Structures -- Small Molecule Effectors of Myosin Function -- Single-Molecule Biophysical Techniques to Study Actomyosin Force Transduction -- High-Speed Atomic Force Microscopy to Study Myosin Motility -- How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches -- How Actin Tracks Affect Myosin Motors -- Myosins in the Nucleus -- Myosins in Cytokinesis -- Myosins and Disease -- Myosins and Hearing -- The Actomyosin Systems in Apicomplexa -- Approaches to Identify and Characterise MYO6-Cargo Interactions -- Class IX Myosins: Motorized RhoGAP Signaling Molecules -- Myosin X -- Myosin XVI -- Myosin XVIII -- Myosin XIX.
    Abstract: Myosins are molecular motors that use the energy from ATP hydrolysis to move and exert tension on actin filaments. Although the best-known myosin is myosin II, which powers skeletal muscle contraction, there are at least two dozen classes of myosins, and cells generally express multiple isoforms. Myosins are involved in multiple cellular activities including cell structure, cell migration, intracellular trafficking, and cell-cell contact. Importantly, loss of function and mutation are associated with diseases including myopathies, hearing impairment, glomerulosclerosis, and cancer. Written by international experts in myosin motors and the approaches used to study them, this book is expected to provide a comprehensive assessment of the current status of our understanding of the structure and molecular mechanism of myosins and their cellular roles.
    Type of Medium: Online Resource
    Pages: XI, 455 p. 116 illus., 97 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030380625
    Series Statement: Advances in Experimental Medicine and Biology, 1239
    URL: https://doi.org/10.1007/978-3-030-38062-5
    DOI: 10.1007/978-3-030-38062-5
    DDC: 610.72
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  • 21
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    Online Resource
    Single-cell Sequencing and Methylation : Methods and Clinical Applications (2020)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Bioinformatics. ; Cancer. ; Biomedical Research. ; Bioinformatics. ; Cancer Biology.
    Description / Table of Contents: Values of single-cell sequencing and methylation in molecular diagnosis and therapy -- Single-cell sequencing in human diseases -- Single-cell sequencing of T cell receptors: A perspective on the technological development and translational application -- DNA Methylation in pulmonary fibrosis -- Molecular regulation and clinical significance of caveolin-1 methylation in chronic lung diseases -- Research advances on DNA methylation in idiopathic pulmonary fibrosis -- DNA Methylation in Chronic Obstructive Pulmonary Disease -- Single cell sequencing: a new dimension in cancer diagnosis -- The Role of Methylation in the CpG Island of the ARHI Promoter Region in Cancers -- Clinical Significance of P16 Gene Methylation in Lung Cancer -- Application of single-cell RNA sequencing in pancreatic cancer and the endocrine pancreas -- Single Cell Sequencing in GU Malignancies -- PI3K Isoform-Selective Inhibitors in Cancer -- Single cell RNA sequencing in human disease: Renal, pancreatic, and viral diseases -- Single-cell sequencing in human genital infections -- PI3kinase Inhibitors in Thrombosis and Cardiovascular Disease -- Use of single-cell microfluidic technology towards therapeutic antibody discovery from single B cells.
    Abstract: With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients.
    Type of Medium: Online Resource
    Pages: VIII, 247 p. 117 illus., 114 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811544941
    Series Statement: Advances in Experimental Medicine and Biology, 1255
    URL: https://doi.org/10.1007/978-981-15-4494-1
    DOI: 10.1007/978-981-15-4494-1
    DDC: 610.72
    Language: English
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  • 22
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    Online Resource
    Problem Solving Questions in Toxicology : A Study Guide for the Board and other Examinations (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Biomedical Research. ; Pharmacology.
    Description / Table of Contents: Part 1 General and Principles of Toxicology -- A Historical Glimpse and Stalwarts -- General Toxicology -- Principles of Toxicology -- Mechanism of Toxicity -- Part 2 Disposition and Kinetics -- Disposition of Toxicants -- Toxicokinetic of Xenobiotics -- Part3 Organ Toxicity -- Target Organ Toxicity -- Part4 Non-Organ-Directed Toxicity -- chemical carcinogenesis -- Genetic Toxicology -- Developmental Toxicology -- Part5 Toxic Agents -- Pesticides -- Metals and Micronutrients -- Solvents. Gasses and Vapors -- Toxicology of Nanomaterial Particles -- Toxic Effects of Calories -- Part6 Plants, Biotoxins and Food Poisonings -- Plant Toxicity -- Biotoxins and Venomous Organisms -- Poisonous Foods and Food Poisonings -- Part7 Radioactive Materials -- Radiation and Radioactive Materials -- Part8 Applications of Toxicology -- Food Toxicology -- Ecotoxicology -- Environmental Toxicology -- Analytical and Clinical Toxicology -- Occupational Toxicology. .
    Abstract: The book provides easy-to-understand diverse specialized topics in toxicology using self- study questions and answers. The answers are in the form of text along with custom made diagrams and explanations that help the student audience to understand and grasp the matter easily. Problem Solving Questions in Toxicology is written specifically as a study guide for the toxicology board and other examinations. .
    Type of Medium: Online Resource
    Pages: XV, 346 p. 46 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504090
    URL: https://doi.org/10.1007/978-3-030-50409-0
    DOI: 10.1007/978-3-030-50409-0
    DDC: 610.72
    Language: English
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  • 23
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    Online Resource
    Deciphering Drug Targets for Alzheimer’s Disease (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Biology. ; Neurosciences. ; Biotechnology. ; Drug delivery systems. ; Biomedical Research. ; Biological Sciences. ; Neuroscience. ; Biotechnology. ; Drug Delivery.
    Description / Table of Contents: Chapter 1.Deciphering New Drug Targets in Alzheimer’s Disease -- Chapter 2. Novel Therapeutic Targets for Treating Alzheimer’s Disease -- Chapter 3. Modified Investigation Tools and Techniques Useful in Alzheimer’s Disease Research -- Chapter 4. Dual Specificity Tyrosine Phosphorylation Regulated Kinase1A (DYRK1A) Inhibitors: The Quest for a Disease-Modifying Treatment for Alzheimer’s Disease -- Chapter 5. β-secretase as a primary drug target of Alzheimer disease: Function, Structure, and Inhibition -- Chapter 6. Endocrine Receptors: The Potential Therapeutic Targets for Alzheimer’s -- Chapter 7. Calcium Channels as a Potential Therapeutic Target for Alzheimer’s Disease -- Chapter 8. Traversing Through the Trajectory of Pathogenic Astrocytes in Alzheimer’s Disease -- Chapter 9. Targeting Mitochondrial Dynamics as a Restorative Approach in the Treatment of Alzheimer’s Disease -- Chapter 10. Epigenetic Therapy for Alzheimer’s Disease -- Chapter 11. Exploring the Diverse Roles of GSK-3ß Kinase in Alzheimer’s Disease -- Chapter 12. Role of Target Fishing in Discovery of Novel Anti-Alzheimer’s Agents: In Silico Applications -- Chapter 13. Multi-Target Directed Ligand Approach in Anti-Alzheimer’s Drug Discovery -- Chapter 14. Investigating the Role of Tau Proteins in Alzheimer’s Disease-From Typical Functioning MAPs to Aberrant Fibrillary Deposits in the Brain -- Chapter 15. The Overview of Drugs Used in Alzheimer’s Disease and Their Molecular Targets.
    Abstract: This book explains the fundamental characteristics and biofunctionality of Alzheimer’s Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer’s Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer’s disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer’s disease treatment.
    Type of Medium: Online Resource
    Pages: XV, 381 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819926572
    URL: https://doi.org/10.1007/978-981-99-2657-2
    DOI: 10.1007/978-981-99-2657-2
    DDC: 610.72
    Language: English
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  • 24
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    Online Resource
    Nutraceuticals and Cancer Signaling : Clinical Aspects and Mode of Action (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Nutrition   . ; Food science. ; Chemistry, Organic. ; Biomedical Research. ; Nutrition. ; Food Science. ; Organic Chemistry.
    Description / Table of Contents: Part I: An overview of cancer and its mechanisms -- 1-A brief overview of cancer, its mechanisms, and prevention methods -- 2-MECHANISMS INVOLVED IN CARCINOGENESIS -- Part II: Functional foods/nutraceuticals as chemo preventive agents -- 3-Tomato (lycopene and β-carotene) and cancer -- 4-Essential Oils from Aromatic Plants in cancer prevention and treatment -- 5-Bee propolis (caffeic acid phenethyl ester) against cancer -- 6-Brown Algae (Fucoxanthin) Against Cancer -- 7-Cruciferous vegetables (indole-3-carbinol, isothiocyanates) against cancer -- 8-Crustacea (carotenoids namely astaxanthins) against cancer -- 9-Curcuma and breast cancer: a focus on cell signaling pathways -- 10-FRUITS AND VEGETABLES IN CANCER -- 11-Garlic: Allyl Sulfur Compounds and Cancer Prevention -- 12-Ginger (gingerols and 6-shogaol) against cancer -- 13-Saffron (crocins) against cancer -- 14-OLIVE LEAF (OLEUROPEIN) AND ITS ROLE IN CANCER: THERAPEUTIC UPDATES -- 15-Honey against cancer -- 16-Soybeans and phytoestrogen rich foods (genistein, daidzein) against cancer -- 17-Tea (catechins including (-)-epigallocatechin-3-gallate) and cancer -- 18-Probiotics and Cancer -- Part III: The role of nutrients in the prevention of cancer -- 19-Vitamins (C, D and E) against cancer -- 20-Minerals (namely selenium) and cancer -- 21-Dietary fibers/beta-glucan and cancer -- 22-Omega-3 Polyunsaturated Fatty Acids and Cancer.
    Abstract: Today's consumers are looking for food products with health-promoting roles in addition to nutritional benefits. With current research showing that nutraceuticals and functional foods rich in specific bioactives may have chemopreventative effects, these products are increasingly popular. However, while much in the literature supports the health-promoting features of these foods, few texts focus on their bioactive agents and their mode of action in cancer signaling. Nutraceuticals and Cancer Signalling: Clinical Aspects and Mode of Action explains the link between nutraceuticals and cancer in terms of clinical trials and modes of action. This book gives an overview of common cancers and their mechanisms, and the most common functional foods and their bioactive components. Individual chapters focus on specific functional foods--including tomatoes, garlic, honey, tea, yoghurt, and many more--their prominent bioactive compounds, and their mode of action in cancer signaling and chemoprevention. Recent findings on cancer-prevention roles of different vitamins and minerals are also discussed. For food scientists, nutritionists, and pharmaceutical experts looking to understand how functional foods can play a role in fighting cancer, this text serves as a one-stop reference.
    Type of Medium: Online Resource
    Pages: IX, 652 p. 52 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030740351
    Series Statement: Food Bioactive Ingredients,
    URL: https://doi.org/10.1007/978-3-030-74035-1
    DOI: 10.1007/978-3-030-74035-1
    DDC: 610.72
    Language: English
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  • 25
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    Online Resource
    Regionalized Management of Medicine (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Therapeutics. ; Medical informatics. ; Translational Research. ; Therapeutics. ; Health Informatics.
    Description / Table of Contents: Introduction: The importance of regionalized management of medicine -- Alcohol use disorders -- Public-private partnerships management in health care: The Portuguese experience -- Management of Clinical Precision Medicine -- Artificial Intelligence in medical management -- Advanced Demand Forecasting and Inventory Management Methods in Hospital Pharmacy -- Clinical Application of Cell-Based Therapies Opportunities and Challenges -- Management of Next-Generation Sequencing (NGS) in Precision Medicine -- Exploration on the Reform of County Medical Integration -- The Regionalization of Medical Management: The Practice and Exploration of Established Fudan-Minhang Medical Alliance -- Bed-occupancy management and hospital planning: a handbook -- Management of severe childhood pneumonia in low resource setting -- The role of mitochondrial-targeted antioxidant, MitoQ, in neurodegenerative disease -- Progression of mitochondria research for clinical potentials -- DNA methylation in pulmonary inflammatory diseases -- Synthetic lethality and lung cancer.
    Abstract: The Book mainly focuses on various aspects of regionalized management of medicine, related with updates of new biotechnology, application of therapeutic strategy, and understanding of disease-associated molecular mechanisms. The book also discusses how medical informatics, systems analysis, database sharing, and artificial intelligent can be applied for improving the quality of hospital managements, disease therapies, regional collaborations, and medical services. This book serves as a professional reference book to clinicians and experts who are interested in medical informatics and artificial intelligence for diseases therapies and therapeutic strategy, better systems analysis and database sharing, and more efficient regional collaborations and medical services.
    Type of Medium: Online Resource
    Pages: X, 226 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811678936
    Series Statement: Translational Bioinformatics, 17
    URL: https://doi.org/10.1007/978-981-16-7893-6
    DOI: 10.1007/978-981-16-7893-6
    DDC: 610.72
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  • 26
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    Online Resource
    Microfluidics and Multi Organs on Chip (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Biomedical engineering. ; Toxicology. ; Cytology. ; Biomedical Research. ; Biomedical Devices and Instrumentation. ; Toxicology. ; Cell Biology.
    Description / Table of Contents: Chapter 1. A Historical and Technological Background to Organs-on-a-Chip -- Chapter 2. Applications of microfluidics -- Chapter 3. Microfluidics based Organ-on-a-chip for cell biology studies -- Chapter 4. Microfluidics in Chemical biology -- Chapter 5. Role of microfluidics in drug delivery -- Chapter 6. Microfluidics in drug discovery -- Chapter 7. Microfludic based sensors -- Chapter 8. Background and Organs-on-a-Chip -- Chapter 9. Culture and co-culture of cells for multi organ on chip -- Chapter 10.Cells and organs on a chip in biomedical sciences -- Chapter 11. Futuristic aspects of organ on a chip -- Chapter 12. Development of Human on a chip -- Chapter 13. Multi-organ on a chip for personalized medicine -- Chapter 14. Development and application of Microfluids in organoid formation -- Chapter 15. Liver on a chip -- Chapter 16. Placenta on Chip: A Modern approach to probe feto-maternal interface -- Chapter 17. Microfluidic retina-on-chip -- Chapter 18. Heart on a chip -- Chapter 19. Kidney on a chip -- Chapter 20. Lungs on a chip -- Chapter 21. Brain on a chip -- Chapter 22. Skin on a chip -- Chapter 23. Organs-on-a-chip in preclinical studies -- Chapter 24. Application of organ on chip in blood brain barrier model -- Chapter 25. Multi organs on a chip in disease modeling -- Chapter 26. Prospects of Medical device on a chip -- Chapter 27. Lab on a chip for precision Medicine -- Chapter 28. Tumour-on-a-chip : Perfusion systems to model the extracellular breast tumour microenvironment:from tumour progression to metastasis formation -- Chapter 29. Building Human In Vitro 3D Models to Replace Animal Studies: During Drug Discovery Reearch: Scientific, Ethical and Regulatory Considerations.
    Abstract: This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.
    Type of Medium: Online Resource
    Pages: IX, 717 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811913792
    URL: https://doi.org/10.1007/978-981-19-1379-2
    DOI: 10.1007/978-981-19-1379-2
    DDC: 610.72
    Language: English
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  • 27
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    Online Resource
    Application and Integration of Omics-powered Diagnostics in Clinical and Public Health Microbiology (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Diseases. ; Genetics. ; Immunology. ; Biomedical Research. ; Diseases. ; Genetics and Genomics. ; Immunology.
    Description / Table of Contents: Ch 1: Overview of Microbial NGS -- Ch 2: WGS for Bacterial Identification and Susceptibility Testing -- Ch 3: WGS for Bacterial Virulence Assessment -- Ch 4: Epidemiological Typing by WGS -- Ch 5: Bioinformatics Approaches for WGS Analysis -- Ch 6: WGS for Clinical Virology -- Ch 7: WGS for Clinical Mycology -- Ch 8: WGS for Clinical Parasitology -- Ch 9: Long Read Sequencing -- Ch 10: Aspects of WGS Integration -- Ch 11: Microbiome Analysis -- Ch 12: Metagenomics of Environmental Samples -- Ch 13: Clinical Metagenomics -- Ch 14: Metagenomics for Pathogen Discovery -- Ch 15: Advanced Applications for MALDI-TOF: Typing -- Ch 16: Advanced Applications for MALDI-TOF: Infectious Diseases and Antibiotic Susceptibility Testing (AST) -- Ch 17: Omics for Food and Water Microbiology -- Ch 18: Omics for Forensic and Post-Mortem Microbiology -- Ch 19: Omics for Antimicrobial Resistance Surveillance -- Ch 20: Total Laboratory Automation.
    Abstract: Various “omics” methods have recently revolutionized molecular diagnostics. Next-generation sequencing (NGS) makes it possible to sequence a human genome in just one day. Whole genome sequencing (WGS) greatly improves the ability to investigate the outbreaks of numerous pathogens. Metagenomics helps to analyze the microbiome, which aids greatly in identifying the pathogenesis of infectious diseases. Proteomic-based methods, namely matrix-assisted laser desorption-ionization time of flight mass spectrometry (MALDI-TOF-MS), have a promising role in identifying myctobacteria and fungi, and predicting antimicrobial resistance. While there are numerous scientific publications on “omics” applications for microbiology, there are relatively few books that review this topic from a clinical diagnostics perspective. This book looks at this field from a holistic viewpoint, instead of limiting by type of “omics” technology, in order to cover the body of knowledge needed for practitioners and academics interested in clinical and public health microbiology. Additionally, it addresses the management, economical, regulatory and operational aspects of integrating these technologies into routine diagnostics.
    Type of Medium: Online Resource
    Pages: VI, 240 p. 17 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030621551
    URL: https://doi.org/10.1007/978-3-030-62155-1
    DOI: 10.1007/978-3-030-62155-1
    DDC: 610.72
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  • 28
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    Online Resource
    Multifaceted Protocols in Biotechnology, Volume 2 (2021)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Biotechnology. ; Biomedical engineering. ; Biomedical Research. ; Biotechnology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Graviola Fruit Extraction by Ionic Liquid Microwave-assisted Extraction (IL-MAE) -- Role of Ionic Liquids in the Enzyme Stabilization: A Case Study with Trichoderma ressie Cellulase -- Role of Ionic Liquids in the Processing of Lignocellulosic Biomass -- Proliferation of rat amniotic stem cell (AFSC) on modified surface microcarrier -- Application of spectroscopic methods for the analysis of non-halal meats in food products: A narrative review -- Identification of Potential Biomarkers of Porcine Gelatin -- Gamma Ray Mutagenesis on Bacteria Isolated from Shrimp Farm Mud for Microbial Fuel Cell Enhancement and Degradation of Organic Waste -- Effect of temperature on antibacterial activity and fatty acid methyl esters of Carica papaya seed extract -- Solid-state Fermentation of Agro-industrial Waste Using Heterofermentative Lacti Acid Bacteria -- Synthesis of chitosan-folic acid nanoparticles as a drug delivery system for propolis compounds.
    Abstract: This contributed volume, “Multifaceted Protocols in Biotechnology, Volume 2”, consists of multidisciplinary methods and techniques commonly used in biotechnology studies. There are two sections covered in this book – Ionic Liquid Related Techniques & Evergreen Biotechnology Techniques. A brief introduction supports each protocol to allow easy learning and implementation. The first section consists of three chapters covering studies in modern biotechnology focusing on the role of ionic liquid techniques in extracting secondary metabolites, enzyme stabilization and biomass processing. The second section covers evergreen methodologies. It comprises five chapters covering topics on microcarrier technology for cell culture; Polymerase Chain Reaction for non-halal sources detection in food; ELISA for biomarker identification; gamma ray-induced mutagenesis for enhancing microbial fuel cells; and the effect of temperature on antibacterial activity of Carica papaya seed extract. This book will be useful to graduate students, researchers, academics, and industry practitioners working in the area of biotechnology.
    Type of Medium: Online Resource
    Pages: VII, 159 p. 45 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030755799
    URL: https://doi.org/10.1007/978-3-030-75579-9
    DOI: 10.1007/978-3-030-75579-9
    DDC: 610.72
    Language: English
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  • 29
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    Online Resource
    Ovarian Cancer Biomarkers : Mapping to Improve Outcomes (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Biomedical Research. ; Medical Genetics. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. General Overview of the Origins and Pathology of Ovarian Cancer -- Chapter 2_An Introduction to the Current Management of Ovarian Cancer in the Era of Precision Oncology -- Chapter 3_The Hallmarks of Ovarian Cancer: Actionable Genetics, Targetable Pathways and Predictive Biomarkers -- Chapter 4_Genetic Alterations in Ovarian Cancer as Prognostic and Predictive Biomarkers of Therapy Response and Surgical Outcomes -- Chapter 5_The Emergence of Circulating Tumor DNA in the Management of Ovarian Cancer -- Chapter 6_Proteomic Biomarkers for Early Detection and Patients’ Stratification in Ovarian Cancer -- Chapter 7_Cutting-edge Technologies and Ovarian Cancer.
    Abstract: This book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. The initial chapter discusses our current understanding of the origin, development, progression and tumorigenesis of ovarian cancer. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer. The book then reviews the role of deep molecular and cellular profiling to overcome challenges that are associated with the treatment of ovarian cancer. It explores the use of genome-wide association analysis to identify genetic variants for the evaluation of ovarian carcinoma risk and prognostic prediction. Lastly, it highlights various diagnostic and prognostic ovarian cancer biomarkers for the development of molecular-targeted therapy.
    Type of Medium: Online Resource
    Pages: XV, 229 p. 9 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811618734
    URL: https://doi.org/10.1007/978-981-16-1873-4
    DOI: 10.1007/978-981-16-1873-4
    DDC: 610.72
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  • 30
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    Online Resource
    Biomedical Translational Research : Drug Design and Discovery (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Drugs Design. ; Pharmaceutical chemistry. ; Genomics. ; Bioinformatics. ; Biomedical Research. ; Structure-Based Drug Design. ; Pharmaceutics. ; Genomics. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Emerging Technologies : Gateway to Understand Molecular Insight of Diseases, Newer Drugs, Their Design and Targeting -- Chapter 2. Polypharmacology: New Paradigms in Drug Development -- Chapter 3. Drug Repurposing in Biomedical Research : Benefits and Challenges -- Chapter 4. Computational Methods for Drug Repurposing -- Chapter 5. Genomic Approaches for Drug Repositioning -- Chapter 6. Organ-On-A- Chip: Novel in-Vitro Model For Drug Discovery -- Chapter 7. Precision Radiomolecular Oncology: Challenging the Classical Statistical Evidence Based Medicine -- Chapter 8. Drug Repositioning of the Phenylpiperazine Derivative Naftopidil in Prostate Cancer Treatment -- Chapter 9. Biomarker Based Drug Discovery and Reverse Translational Approach -- Chapter 10. Nanotechnology in Dentistry -- Chapter 11. Nanoparticles a Potential Breakthrough in Counteracting Multidrug-Resistant Bacterial Infections: A Holistic View on Underlying Mechanisms and Antibacterial Properties -- Chapter 12. Emerging Role of Cannabinoid System Modulators in Treatment of Cancer -- Chapter 13. Nanodrugs : A Futuristic Approach for Treating Nephrolithiasis -- Chapter 14. Lipo Dermaceuticals : Technological Transformation -- Chapter 15. The Importance of Drug Dose Adjustment in Elderly Patients with Special Considerations for Patients on Diverse Co-Medications and Antidepressants -- Chapter 16. Role of Microfluidics and Nano Fluidics in Managing CAD -- Chapter 17. Targeted Gene Delivery Through Magnetofection: The New Face of Medicine -- Chapter 18. Qbd-Steered Systematic Development of Drug Delivery Nanoconstructs : Vital Precepts, Retrospect and Prospects -- Chapter 19. Nanoemulsions: A Potential Advanced Nanocarrier Platform for Herbal Drug Delivery -- Chapter 20. Sirna Encapsulated Nanoparticles for Targeting Dorsal Root Ganglion (Drg) in Diabetic Neuropathic Pain -- Chapter 21. EGFR Targeted Quinazoline Clubbed Heterocycles as Anti-Cancer Agents. Chapter 22. Therapeutic Human Monoclonal Antibodies -- Chapter 23. Hydroxyapatites and Their Biomedical Applications -- Chapter 24. Recent Progress in Applications of Magnetic Nanoparticles in Medicine: A Review -- Chapter 25. Chimeric Antigen Receptor T-Cell Therapy: A Cutting Edge Therapy for Multiple Myeloma -- Chapter 26. Nanoparticles-Associated Lipopeptides: A New Class of Antimicrobials -- Chapter 27. Antimicrobial Applications of Engineered Metal-Based Nanomaterials -- Chapter 28. Strengthening Immunity-Ayurveda & Medicinal Plants -- Chapter 29. The Pathophysiology of Liver Disorders and Pharmacotherapy Options with Special Reference to Traditional Herbal Medicines: A Comprehensive Review -- Chapter 30. Polymeric Vehicles for Controlled Delivery of Ayurvedic Drugs for Wound Management.
    Abstract: This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents.
    Type of Medium: Online Resource
    Pages: XII, 599 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811692321
    URL: https://doi.org/10.1007/978-981-16-9232-1
    DOI: 10.1007/978-981-16-9232-1
    DDC: 610.72
    Language: English
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  • 31
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    Online Resource
    Biosensors and Biochips (2021)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Biophysics. ; Senses and sensation. ; Nanoscience. ; Biotechnology. ; Biomedical Research. ; Sensory Systems. ; Nanophysics. ; Chemical Bioengineering.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Bioreceptors -- Chapter 3. Catalytic Biosensors -- Chapter 4. Affinity Biosensors -- Chapter 5. Affinity Biosensors -- Chapter 6. Label-free Biosensors -- Chapter 7. Bioreceptor Immobilization -- Chapter 8. Biochips. Chapter 9. Genome Sequencing -- Chapter 10. Genome Sequencing -- Chapter 11. Micro Electrode Arrays, Implants and Organs-on-a-Chip -- Appendix.
    Abstract: This textbook describes the basic principles and mechanism of action of biosensor systems, and introduces readers to the various types of biosensors; from affinity biosensors to catalytic, optical and label-free biosensors, the most common systems are explained in detail. Dedicated advanced sections focus on biochips and genome sequencing methods as well as organs-on-a-chip. The textbook helps readers to understand the elementary components of biosensors, and to identify and illustrate each function in the biosensor information flow, from recognition to transduction and transmission. Furthermore, readers will receive guidance in critically analyzing published studies on biosensor research, helping them to develop appropriate concepts and independently propose their own solutions. The textbook is intended for master’s students in bioengineering, biophysics, biotechnology and pharmacology that need a solid grasp of biosensor system technologies and applications, as well as students in related medical technological fields.
    Type of Medium: Online Resource
    Pages: XVIII, 328 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030764692
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-76469-2
    DOI: 10.1007/978-3-030-76469-2
    DDC: 610.72
    Language: English
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  • 32
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    Online Resource
    Glycosignals in Cancer : Molecular Assembly and Recognition (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Life sciences. ; Cytology. ; Internal medicine. ; Biomedical Research. ; Medical Genetics. ; Life Sciences. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: Part I. Search for novel tumor epitopes related to carbohydrates -- Chapter 1.1. The ganglioside structures: chemistry and biochemistry -- Chapter 1.2. Fucosylated proteins as cancer biomarkers -- Part II. Assembly of glycoconjugates -- Chapter 2.1. Siglec-7 and synthetic sialylpolymer -- Chapter 2.2. Role of Sialyl-Tn antigen in Cancer Metastasis -- Chapter 2.3. Insights into the Role of Chondroitin Sulfate in Cancer -- Part III. Signaling pathways modulated by glycosylation -- Chapter 3.1. Significance of FUT8in pancreatic cancer and others -- Chapter 3.2. Effects of Bullfrog sialic acid-binding lectin in cancer cells -- Part IV. Interaction between carbohydrate and carbohydrate-recognizing molecules -- Chapter 4.1. Opposite functions of mono- and disialylated glycosphingolipids on the membrane of cancer cells -- Chapter 4.2. Tumor progression through interaction of mucins with lectins and subsequent signal transduction -- Part V. Clinical trials targeting glycosignals -- Chapter 5.1. Immunotherapy of Neuroblastoma Targeting GD2 and Beyond.
    Abstract: This book, now in an extensively revised second edition, provides a comprehensive summary of the latest knowledge regarding glycosignals and a thorough analysis of their involvement in not only cancers but also other refractory conditions such as chronic inflammatory disorders. Many relevant topics are covered, including the search for novel tumor epitopes related to carbohydrates, the assembly of glycoconjugates, the modulation of signaling pathways by glycosylation, and interactions between complex carbohydrates and their recognition molecules. The role of various research approaches, for example advanced mass spectrometry, high-resolution imaging, and bioinformatics, is closely examined, and the results of novel therapeutic trials targeting glycosignals are discussed. The book will be essential reading for students and young researchers with an interest in glycoscience. In presenting new results and approaches and identifying areas for future research, it will also be of benefit for specialists in the field.
    Type of Medium: Online Resource
    Pages: VI, 238 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789811977329
    URL: https://doi.org/10.1007/978-981-19-7732-9
    DOI: 10.1007/978-981-19-7732-9
    DDC: 610.72
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  • 33
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    Online Resource
    Progress in Heritable Soft Connective Tissue Diseases (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Physiology. ; Internal medicine. ; Biomedical Research. ; Medical Genetics. ; Physiology. ; Internal Medicine.
    Description / Table of Contents: Basic structure, physiology and biochemistry of connective tissues and extracellular matrix collagens -- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life -- Basic Components of Connective Tissues and Extracellular Matrix: Fibronectin, Fibrinogen, Laminin, Elastin, Fibrillins, Fibulins, Matrilins, Tenascins and Thrombospondins -- Proteoglycans and Diseases of Soft Tissues -- Growth Factor Roles in Soft Tissue Physiology and Pathophysiology -- Connective Tissue Disorders and Cardiovascular Complications: The Indomitable Role of Transforming Growth Factor-β Signaling -- The Pathophysiology and Pathogenesis of Marfan Syndrome -- Ehlers-Danlos syndromes, joint hypermobility and hypermobility spectrum disorders -- Ehlers–Danlos Syndrome Associated with Glycosaminoglycan Abnormalities -- Loeys-Dietz Syndrome -- Meester-Loeys syndrome -- Clinical and Molecular Delineation of Cutis Laxa Syndromes: Paradigms for Elastic Fiber Homeostasis -- Collagen VI Muscle Disorders: Mutation Types, Pathogenic Mechanisms and Approaches to Therapy -- Connective Tissue Disorders in Domestic Animals.
    Abstract: This volume represents a substantially revised and updated 2nd edition of a reference handbook on major structural components of soft connective tissues and a whole slew of heritable diseases of soft connective tissues. The number of clearly identifiable and distinct disorders has grown somewhat since the 1st edition in 2014, e.g., Ehlers-Danlos syndrome has now 13 entities. A brand new syndrome, Meester Loeys syndrome carrying the name of Bart Loeys was added as a companion to Loeys-Dietz syndrome. Numerous variations of cutis laxa and joint mobility disorders have been discovered taking advantage of recent advancements in genetic analysis. We have acquired better understanding of pathogenesis and biochemical changes in some other, more established entities, such as Marfan and collagen VI myopathies where better management and possible treatment are on the horizon. Even in the case of connective tissue diseases in domestic animals some progress has been made. All these updates were contributed by a group of distinguished and preeminent physicians and scientists, all of them not just working in the field but making new discoveries described by them. Readers will notice that seemingly there is an overlap among many of these disorders. And indeed, many of them, if not most are interconnected because of the prominent roles of TGFβ, of fibrillin microfibrils and collagen fibril assembly (and other molecules) playing in connective tissues physiology, and by extension in pathogenesis of many disorders described in the book. What I found particularly helpful that author(s) of each chapter bring their own perspective even when described closely related mechanism of the disease. These observations should help with diagnosis and management of such cases. The first chapters are more general, concentrating more on the physiology, structure and biochemistry of normal soft tissues. That should help in better understanding of the pathophysiology. Last but not least, the chapters are very readable, more like detective stories than dry description of genetic/biochemical defects. I do hope that basic scientists and clinicians with similar and diverse interests alike will appreciate this volume and will be inspired by it to develop their research in the field.
    Type of Medium: Online Resource
    Pages: IX, 343 p. 1 illus. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030806149
    Series Statement: Advances in Experimental Medicine and Biology, 1348
    URL: https://doi.org/10.1007/978-3-030-80614-9
    DOI: 10.1007/978-3-030-80614-9
    DDC: 610.72
    Language: English
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    Online Resource
    Basic Organic Chemistry for the Life Sciences (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Life sciences. ; Chemistry, Organic. ; Enzymology. ; Biochemistry. ; Biomedical Research. ; Life Sciences. ; Organic Chemistry. ; Enzymology. ; Biochemistry.
    Description / Table of Contents: 1. Alkanes, composition, constitution, and configuration -- 2. Functional groups -- 3. Electronic structure of organic molecules -- 4. Alkenes and alkynes -- 5. Substitutions on saturated carbon atom -- 6. Nucleophilic additions -- 7. Stereochemistry, symmetry, and molecular chirality -- 8. Derivatives of carboxylic acids -- 9. Electrophilic substitutions -- 10. Pericyclic reactions -- 11. Organic natural products -- 12. Organic supramolecular and supermolecular structures.
    Abstract: This textbook is designed for students of biology, molecular biology, ecology,medicine, agriculture, forestry and other professions where the knowledge of organic chemistry plays an important role. The work may also be of interest to non-professionals, as well as to teachers in high schools. The book consists of 13 chapters that cover the essentials of organic chemistry, including - basic principles of structure and constitution of organic compounds, - the elements of the nomenclature, - the concepts of the nature of chemical bond, - introductions in NMR and IR spectroscopy, - the concepts and main classes of the organic reaction mechanisms, - reactions and properties of common classes or organic compounds, - and the introduction to the chemistry of the natural organic products followed by basic principles of the reactions in living cells. This second edition includes revisions and suggestions made by the readers of the first edition and the author's colleagues. In addition, it includes substantial changes compared to the first edition. The chapter on Cycloaddition has been completed by including the other pericyclic reactions (sigmatropic rearrangements, electrocyclic reactions). The chapter on Organic Natural Products has been extended to include new section covering the principles of organic synthesis. New chapter "Organic Supramolecular and Supermolecular Structures" is added. This chapter covers the basic knowledge about the molecular recognition, supramolecular structures, and the mechanisms of the enzyme catalyzed reactions.
    Type of Medium: Online Resource
    Pages: XV, 205 p. 339 illus., 114 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030924386
    URL: https://doi.org/10.1007/978-3-030-92438-6
    DOI: 10.1007/978-3-030-92438-6
    DDC: 610.72
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    Online Resource
    Food Packaging: The Smarter Way (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Food science. ; Nanotechnology. ; Biomedical Research. ; Food Science. ; Food Engineering. ; Food Nanotechnology.
    Description / Table of Contents: Chapter 1. Chapter 1. Food packaging industry - An introduction -- Chapter 2. Toward Smarter Food Packaging -- Chapter 3. Novel packaging development, assessment and authentication using smart technologies, non-invasive biometric sensory tools, and artificial intelligence -- Chapter 4. Biodegradable packaging materials and techniques to improve their performance -- Chapter 5. Smart Freshness Indicator for Animal Based Products Packaging - Current Status.-Chapter 6. Packaging of dairy products-Emerging strategies -- Chapter 7. Functional packaging materials for fishery products applications -- Chapter 8. Edible films and coatings: Major challenges and potential applications in food Packaging: A Review.-Chapter 9. Role of sensors to improve food/beverage packaging -- Chapter 10. Functional nanomaterials for food packaging applications -- Chapter 11. Rules and regulations related with packaging.
    Abstract: This book reviews the science and technology of food packaging and covers the potential innovations in the food packaging sector. At the same time, it highlights the issues and prospects for linking the laboratory research to the market. In addition to typical packaging requirements such as food quality, shelf life, protection, communication, and marketing, the book emphasizes the need for novel packaging materials, including biodegradable packaging for a variety of food products. A wide range of food products has been kept in focus and includes animal-based food products such as dairy products and sea foods. The book presents the next level of packaging solutions i.e., smart packaging with the applications of potential tools such as intelligent and active packaging, and includes the latest research on emerging digital technologies for packaging development, assessment, and acceptability. It further highlights the strategies including blends, reinforcing agents, cold plasma, UV light applications, chemical, and enzymatic methods and explores the new opportunities leading to improvement in the packaging performance. Smart freshness indicator applications, including gas and time-temperature indicators for quality and safety of packaged products, have been covered in detail. The book also includes the functional characteristics of edible films and coatings, including their bioactive characteristics. Finally the book presents the rules and regulation related to packaging.
    Type of Medium: Online Resource
    Pages: XI, 286 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811671968
    URL: https://doi.org/10.1007/978-981-16-7196-8
    DOI: 10.1007/978-981-16-7196-8
    DDC: 610.72
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    Online Resource
    Coronavirus Therapeutics – Volume II : Clinical Management and Public Health (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Virology. ; Clinical medicine Research. ; Epidemiology. ; Public health. ; Biomedical Research. ; Virology. ; Clinical Research. ; Epidemiology. ; Public Health.
    Description / Table of Contents: Clinical features, diagnostic evaluation and management of COVID-19 patients -- Outbreak of COVID-19: A Detailed Overview and Its Consequences -- A paradigm gap in host-pathogen interaction studies: Lesson from the COVID-19 pandemic -- SARS/CoV-2: Behavioral Host Manipulation -- Management of COVID-19 in the Intensive Care Unit -- First wave of Covid-19 pandemic in Italy: data and evidence -- Risk factors for COVID-19: diabetes, hypertension and obesity -- Current challenges for the effective management of the COVID-19 pandemic -- COVID-19 Outbreak Challenges in Indian Migrant Pregnant and Lactating Mothers: Learnt Lesson Demands Phronesis and Hierarchical Strategies for Such Future Pandemics -- COVID-19 and Extracorporeal Membrane Oxygenation -- COVID-19's Clinical-Pathological Evidence in Relation to its Repercussion on the Central and Peripheral Nervous System -- Anatomopathological Aspects and Clinical Correlation of COVID-19: A Systematic Review -- SARS-CoV-2 liability: the hidden mystery behind its presentation in children.
    Abstract: The book Coronavirus Therapeutics Volume II provides the most comprehensive review on contemporary knowledge on the consequences during the outbreak of Coronavirus. This also describes the clinical features, diagnostic evaluation and management of Coronavirus patients. Using an integrative approach to the understanding of paradigm gap in host-pathogen interaction studies to the management of Coronavirus patients in the Intensive Care Unit to the current challenges for the effective management of Coronavirus pandemic risk factors including diabetes, hypertension, obesity and repercussion on the central and peripheral nervous system. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 241 p. 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030851132
    Series Statement: Advances in Experimental Medicine and Biology, 1353
    URL: https://doi.org/10.1007/978-3-030-85113-2
    DOI: 10.1007/978-3-030-85113-2
    DDC: 610.72
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    Coronavirus Therapeutics – Volume I : Basic Science and Therapy Development (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Virology. ; Clinical medicine Research. ; Epidemiology. ; Biomedical Research. ; Virology. ; Clinical Research. ; Epidemiology.
    Description / Table of Contents: Origin and structural biology of Novel Coronavirus (SARS-CoV-2) -- The Molecular Virology of Coronaviruses with Special Reference to SARS-CoV-2 -- Epidemiology, transmission and molecular immunopathology of SARS-CoV-2 -- Epidemiology and Etiopathogeny of Covid-19 -- Immunological and Hematological Response in COVID-19 -- Toll-like receptors (TLRs) as Therapeutic Targets for Treating SARS-CoV-2: An Immunobiological Perspective -- Potential drug strategies to target Coronaviruses -- Possible therapeutic intervention strategies for COVID-19 by manipulating the cellular proteostasis network -- The potential impact of statins in the treatment of patients with COVID-19 infection -- Anticoronavirus activity of water-soluble pristine C60 fullerenes: in vitro and in silico screening -- Application of Nanoscale materials and nanotechnology against viral infection: A special focus on Coronaviruses -- Obesity: A Risk Factor for Covid-19 -- Cytokine Storm and Failed Resolution in COVID-19: Taking Cue from Multiple Sclerosis.
    Abstract: The book Coronavirus Therapeutics Volume I provides the most comprehensive review on contemporary knowledge on the origin, structural biology and molecular aspects of Coronaviruses. It also describes the etiology and pathogeny and therapeutic targets including vaccine drug candidates against Coronaviruses in the light of current scientific knowledge. Using an integrative approach to the understanding of Coronaviruses structure, function and immunobiology, the contributors provide a synopsis of novel mechanisms by which Coronaviruses can be treated. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 222 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030851095
    Series Statement: Advances in Experimental Medicine and Biology, 1352
    URL: https://doi.org/10.1007/978-3-030-85109-5
    DOI: 10.1007/978-3-030-85109-5
    DDC: 610.72
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    Application of Omic Techniques to Identify New Biomarkers and Drug Targets for COVID-19 (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biochemical markers. ; Proteins. ; Metabolism. ; Genomics. ; Biomarkers. ; Proteins. ; Metabolism. ; Genomics.
    Description / Table of Contents: Chapter 1. The COVID-19 Pandemic: SARS-CoV-2 Structure, Infection, Transmission, Symptomology and Variants of Concern -- Chapter 2. Long-term Vaccination and Treatment Strategies for COVID-19 Disease and Future Coronavirus Pandemics -- Chapter 3. Consequences of the Lockdown - Domestic Violence during the COVID-19 Pandemic -- Chapter 4. Psychological distress impact of Coronavirus disease (COVID-19) outbreak on three continents: A systematic review and meta-analysis -- Chapter 5. A Molecular Biomarker-based Triage Approach for Targeted Treatment of Post-COVID-19 Syndrome Patients with Persistent Neurological or Neuropsychiatric Symptoms -- Chapter 6. Genetic Associations with Coronavirus Susceptibility and Disease Severity -- Chapter 7. COVID Diagnostics: from Molecules to Omics -- Chapter 8. Assessing Biomarkers in Viral Infection -- Chapter 9. Proteomic Investigation of COVID-19 Severity During the Tsunamis Second Wave in Mumbai -- Chapter 10. NMR-Metabolomics in COVID-19 Research -- Chapter 11. Potential Biomarkers of Mitochondrial Dysfunction Associated with COVID-19 Infection -- Chapter 12. Red Cell Distribution Width as a Prognostic Indicator for Mortality and ICU Admission in Patients with COVID-19 -- Chapter 13. Predicting the COVID-19 Patients Status using Chest CT Scan Findings: A Risk Assessment Model Based on Decision Tree Analysis -- Chapter 14. Inferring Recombination Events in SARS-CoV-2 Variants In Silico -- Chapter 15. Amplicon-based Nanopore Sequencing of Patients Infected by the SARS-CoV-2 Omicron (B.1.1.529) Variant in India -- Chapter 16. Perspectives on Rapid Antigen Tests for Downstream Validation and Development of Theranostics -- Chapter 17. Machine Learning and COVID-19: Lessons from SARS-CoV-2 -- Chapter 18. The Relationship between Psoriasis, COVID-19 Infection and Vaccination during Treatment of Patients -- Chapter 19. Immunogenicity of Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV; Sinopharm) and Short-term Clinical Outcomes in Vaccinated Solid Organ Transplant Recipients: A Prospective Cohort Study -- Chapter 20. Spices and Biomarkers of COVID-19: A Mechanistic and Therapeutic Perspective -- Chapter 21. Antiviral Mechanisms of Curcumin and its Derivatives in Prevention and Treatment of COVID-19: A review -- Chapter 22. Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial -- Chapter 23. Chronobiological Efficacy of Combined Therapy of Pelargonium Sidoides and Melatonin in Acute and Persistent Cases of COVID-19: A Hypothetical Approach -- Chapter 24. The Potential Effect of Royal Jelly on Biomarkers Related to COVID-19 Infection and Severe Progression -- Chapter 25. Statins: Beneficial Effects in Treatment of COVID-19 -- Chapter 26. Multiplex Immunoassay Approaches Using Luminex® xMAP® Technology for the Study of COVID-19 Disease -- Chapter 27. Rapid Detection of SARS-CoV-2 Variants of Concern by Genomic Surveillance Techniques.
    Abstract: The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected nearly every country and territory in the world. Although worldwide vaccination efforts have reduced the risk of serious disease outcomes, disparities in distribution have led to multiple waves of SARS-CoV-2 outbreaks and the emergence of variants of concern, some of which have enhanced infectivity and ability to evade existing vaccines. Hence there is an increasing interest in understanding the evolution of viruses like SARS-CoV-2, as well as improving our capacity to effectively current and manage future pandemics. This new volume reviews the most effective omic techniques for increasing our understanding of COVID-19, to improve diagnostics, prognostics, and genomic surveillance, and to facilitate development of effective treatments and vaccines. Chapters are written by an international team of experts and explore methods in the areas of genomics, transcriptomics, proteomics, and metabolomics. Techniques used to assess physiological function at the molecular level and artificial intelligence approaches used for more effective validation and translation of biomarker candidates into clinical use are also discussed. This book is an excellent resource for researchers studying biomarkers, virology, metabolic diseases, and infectious diseases, as well as clinical scientists, physicians, drug company scientists, and healthcare workers.
    Type of Medium: Online Resource
    Pages: XI, 513 p. 87 illus., 74 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031280122
    Series Statement: Proteomics, Metabolomics, Interactomics and Systems Biology, 1412
    URL: https://doi.org/10.1007/978-3-031-28012-2
    DOI: 10.1007/978-3-031-28012-2
    DDC: 610.72
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    Targets of Cancer Diagnosis and Treatment : Ion Transport in Tumor Biology (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Internal medicine. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Internal Medicine. ; Physiology.
    Description / Table of Contents: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges -- Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer -- Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk -- Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics -- Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research -- Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions -- Ion Transport and Radioresistance -- Ion Transporting Proteins and Cancer: Progress and Perspectives.
    Abstract: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges Alina L. Capatina, Dimitris Lagos, and William J. Brackenbury Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer Ana Ramírez, Janice García-Quiroz, Luis Aguilar-Eslava, Yesennia Sánchez-Pérez, and Javier Camacho Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk Jerry J. Fan and Xi Huang Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics Umberto Banderali, Luigi Leanza, Najmeh Eskandari, and Saverio Gentile Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research Marie Potier-Cartereau, William Raoul, Gunther Weber, Karine Mahéo, Raphael Rapetti-Mauss, Maxime Gueguinou, Paul Buscaglia, Caroline Goupille, Nelig Le Goux, Souleymane Abdoul-Azize, Thierry Lecomte, Gaëlle Fromont, Aurélie Chantome, Olivier Mignen, Olivier Soriani, and Christophe Vandier Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions Jason T. Anderson, Kevin M. Huang, Maryam B. Lustberg, Alex Sparreboom, and Shuiying Hu Ion Transport and Radioresistance Bastian Roth and Stephan M. Huber Ion Transporting Proteins and Cancer: Progress and Perspectives Mustafa B. A. Djamgoz.
    Type of Medium: Online Resource
    Pages: X, 277 p. 30 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031039942
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 183
    URL: https://doi.org/10.1007/978-3-031-03994-2
    DOI: 10.1007/978-3-031-03994-2
    DDC: 610.72
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    Mechanisms and Emerging Therapies in Tremor Disorders (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Neurology . ; Neurosciences. ; Nervous system Diseases. ; Biomedical Research. ; Neurology. ; Neuroscience. ; Neurological Disorders.
    Description / Table of Contents: PART I: Fundamental Aspects -- Chapter 1. Definition of Tremor -- Chapter 2. Membrane Mechanisms of Tremor -- Chapter 3 Advances in the Genetics of Human Tremor -- Chapter 4. Two origins of tremors related to the Guillain-Mollaret triangle: the forward model-related tremor and the inferior olive oscillation-related tremor -- PART II:Tremor in Clinical Practice -- Chapter 5. Physiologic Tremor -- Chapter 6. Rest Tremor -- Chapter 7. Postural Tremors -- Chapter 8. Isometric Tremor -- Chapter 9. Essential Tremor and Other Forms of Kinetic Tremor -- Chapter 10. Cerebellar lesions and tremor -- Chapter 11. Orthostatic Tremor -- Chapter 12. Posttraumatic Tremor and Other Posttraumatic Movement Disorders -- Chapter 13 Tremor in Childhood -- Chapter 14. Metabolic Causes of Tremor -- Chapter 15. Drug-Induced Tremor -- Chapter 16. Tremor: The Clinical Approach to Reach the Diagnosis -- PART III: Assessment of tremor -- Chapter 17. Signal Processing -- Chapter 18. Diffusion imaging in Tremor -- Chapter 19. The role of the noradrenergic system in tremor pathogenesis -- Chapter 20. Metabolic Networks in Parkinson’s Disease -- PART IV: Therapies -- Chapter 21. Deep brain stimulation for tremor -- Chapter 22 Mechatronic Devices for Upper Limb Tremor.
    Abstract: Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.
    Type of Medium: Online Resource
    Pages: X, 558 p. 86 illus., 59 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031261282
    Series Statement: Contemporary Clinical Neuroscience,
    URL: https://doi.org/10.1007/978-3-031-26128-2
    DOI: 10.1007/978-3-031-26128-2
    DDC: 610.72
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    Microplastic Occurrence, Fate, Impact, and Remediation (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Analytical chemistry. ; Toxicology. ; Biomedical Research. ; Analytical Chemistry. ; Toxicology.
    Description / Table of Contents: Microplastic research publications from 1991 to 2020 -- Characterization and toxicology of microplastics in soils, water and air -- Coral feeding behavior on microplastics -- Microplastics remediation in the aqueous environment -- Removal of environmental microplastics by advanced oxidation processes -- Techniques for removal and degradation of microplastics -- Occurrence and removal of microplastics in wastewater treatment plants -- Microplastic souces, transport, exposure, analysis and removal -- Airborne microplastics in outdoor and indoor environments -- Nanoplastic sources, characterization, ecological impact, remediation and policies -- Microplastics in soil-plant systems.
    Abstract: Microplastics and nanoplastics have been recently found in most environmental media and in living organisms, thus representing a serious health concern of yet poorly known adverse consequences. This book summarizes recent findings on the sources, behavior, transformation, toxicity and remediation of microplastics, with focus on soils, water, wastewater, air, soils, plants and corals. Advanced methods for sampling, characterization, removal and degradation of microplastics.
    Type of Medium: Online Resource
    Pages: VIII, 282 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031363511
    Series Statement: Environmental Chemistry for a Sustainable World, 73
    URL: https://doi.org/10.1007/978-3-031-36351-1
    DOI: 10.1007/978-3-031-36351-1
    DDC: 610.72
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    Textbook of Forensic Science (2023)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Forensic sciences. ; Medical jurisprudence. ; Biomedical Research. ; Forensic Science. ; Forensic Medicine.
    Description / Table of Contents: Module 1_Introduction to Forensic Science & Crime -- Module 2_Criminalistics -- Module 3_ Forensic Biological Sciences -- Module 4_Forensic Physical Sciences -- Module 5_Forensic Chemical Sciences -- Module 6_Emerging fields in Trends in Forensics.
    Abstract: This textbook provides essential and fundamental information to modern forensics investigations. It discusses criminalistics and crime scene aspects, including investigation, management, collecting and packaging various types of physical evidence, forwarding, and chain of custody. It presents fundamental principles, ethics, challenges and criticism of forensic sciences and reviews the crime typologies, the correlates of crime, criminology, penology, and victimology. It provides a viewpoint on legal aspects, including types of evidence, the procedure in the court and scrutiny of the evidence and experts. The book summarizes forensic serological evidences such as blood, semen, saliva, milk-tears, sweat, vaginal fluids, urine, and sweat. It also provides an overview of forensic examination of different types of evidence and also includes comprehensive detailing of forensic ballistics including firearm classification, bullet comparison and matching. Further, it explores the examinations of drugs, chemicals, explosives, and petroleum products. It focuses on the various aspects of forensic toxicology, including the study of various poisons/toxins, associated signs and symptoms, a fatal dose /fatal period of poisons. The book also emphasizes digital and cyber forensics, including classification, data recovery tools, encryption and decryption methods, image, and video forensics. It is a useful resource for graduate and post-graduate students in the field of Forensic Science.
    Type of Medium: Online Resource
    Pages: XV, 839 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819913770
    URL: https://doi.org/10.1007/978-981-99-1377-0
    DOI: 10.1007/978-981-99-1377-0
    DDC: 610.72
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    Crime Scene Management within Forensic Science : Forensic Techniques for Criminal Investigations (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Forensic sciences. ; Toxicology. ; Biomedical Research. ; Forensic Science. ; Toxicology.
    Description / Table of Contents: 1 Forensic Dna Analysis: A Powerful Investigative Tool -- 2 “Crime Scene Management Within Forensic Science-Forensic Techniques For Criminal Investigations -- 3 Small Size, Big Impact: Insects For Cadaver Examination -- 4 Dermatoglyphics & Other Impressions: Deciphering The Potential Of A Unique Hominid Niche -- 5 Postmortem Toxicology: A facet of drugs of expedites crimes -- 6 Forensic Biology: A Passport For Biological Evidence -- 7 Sexual offences: Recent methods of Investigation -- 8 Investigation Of Disaster Victim Identification -- 9 Review On Clinical Forensic Medicine -- 10 Firearms and Ammunitions: A sentient approach in criminal investigation -- 11 Digital and Cyber Forensics: A Contemporary evolution in Forensic Sciences -- 12 Fire Investigation: Arson Or Accidental -- 13 Psychological Evaluations: An Indoor game of Criminal Minds -- 14 Competence of Evidences: A Pragmatic Approach in Court of Law -- 15 Penology: A friend or foe for criminal justice system -- 16 Chain Of Custody: Scaling The Investigation To The Event. .
    Abstract: This book, the second volume of Crime Scene Management in Forensic Sciences, reviews the role and impact of forensic evidence in criminal investigations. It also addresses the importance of post mortem examination in criminal cases. The book investigates the use of insects and arthropods to estimate post mortem intervals during forensic investigations. Further, it discusses the physiological effects of xenobiotics at the time of death, based on their concentration and distribution in the body at autopsy. Importantly, it also discusses digital forensic investigation, which can be used for the analysis of digital evidence produced at a court of law. Lastly, it defines the structure and legal framework of these forensic evidences for the effective administration of the criminal justice system. It is an excellent source of information for forensics scientists and legal professionals.
    Type of Medium: Online Resource
    Pages: VIII, 418 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811666834
    URL: https://doi.org/10.1007/978-981-16-6683-4
    DOI: 10.1007/978-981-16-6683-4
    DDC: 610.72
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    Nuclear Receptors in Human Health and Disease (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Molecular biology. ; Metabolism. ; Genetics. ; Cytology. ; Biomedical Research. ; Molecular Biology. ; Metabolism. ; Genetics and Genomics. ; Cell Biology.
    Description / Table of Contents: Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index.
    Abstract: This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.
    Type of Medium: Online Resource
    Pages: XII, 346 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031118364
    Series Statement: Advances in Experimental Medicine and Biology, 1390
    URL: https://doi.org/10.1007/978-3-031-11836-4
    DOI: 10.1007/978-3-031-11836-4
    DDC: 610.72
    Language: English
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    Approaches for Science Illustration and Communication (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Anatomy. ; Information visualization. ; Biophysics. ; Biomedical Research. ; Anatomy. ; Data and Information Visualization. ; Bioanalysis and Bioimaging.
    Description / Table of Contents: Chapter 1. The Importance of Integrating the Visual Arts into the Medical Curriculum -- Chapter 2. Using Medical Illustration to Improve Understanding of Endometriosis -- Chapter 3. Editorial Medical and Scientific Illustration -- Chapter 4. Current Approaches in Narrative Medical Visualization -- Chapter 5. Animation for Science Communication: A Description of the Production Process and Contexts for Using Science Animation -- Chapter 6. Effect of the Rings: A Visual Story Design Comparing Three Chemical Characters -- Chapter 7. Diabetes Year One, Random Fluctuations and Mental Goblins: Auto-Ethnographic Pathographies and Medical Comics -- Chapter 8. Playing with Science: Games as a Medium of Science Communication -- Chapter 9. Increasing Microbiology Literacy about the Public Health Threat of Antimicrobial Resistance Through Art-Science Interactions -- Chapter 10. Collaged Creatures: Using Collage Art Practice and Posthuman Ethics to Discuss Bioengineering Hybrids.
    Abstract: This edited book explores the breadth of approaches undertaken by scientists, artists and communicators in their crucial role making science accessible, engaging and impactful. Contemporary approaches in science illustration and visualization include a variety of creative methodologies that are valuable for effective communication, teaching, learning and professional practice. These range in method from anatomical drawings used in medical curricula, to 2D animations and editorial illustrations available in the public realm. They also include unexpected approaches such as the use of tabletop board games, comics and collage in understanding our bodies, emergent health threats and cutting-edge science developments. If you are a scientist seeking to enhance your ability to communicate your research or an artist interested in biomedical visualization, this volume serves as an introduction to contemporary approaches in science illustration and communication. By understanding the creative methods and techniques employed in this field, we can collectively work towards fostering a deeper appreciation of art in science, and continue to captivate and inspire audiences worldwide. .
    Type of Medium: Online Resource
    Pages: XVI, 252 p. 158 illus., 140 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031416521
    Series Statement: Biomedical Visualization, 4
    URL: https://doi.org/10.1007/978-3-031-41652-1
    DOI: 10.1007/978-3-031-41652-1
    DDC: 610.72
    Language: English
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    Polymeric Biomaterials for Tissue Regeneration : From Surface/Interface Design to 3D Constructs (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Regenerative medicine. ; Biomaterials. ; Biomedical Research. ; Regenerative Medicine and Tissue Engineering. ; Biomaterials.
    Description / Table of Contents: Chapter 1. An Introduction to Scaffolds, Biomaterial Surfaces, and Stem Cells -- Part I. Structural Scaffolds and Bio-activation -- Chapter 2. Polymeric and Biomimetic ECM Scaffolds for Tissue Engineering Applications -- Chapter 3. Versatile Hydrogels in Regenerative Medicine -- Chapter 4. Multilayer Microcapsules with Tailored Structures and Properties as Delivery Carriers for Drugs and Growth Factors -- Part II Biomaterials Surfaces/Interfaces and Bio-interactions. Chapter 5. Interactions of Biomaterial Surfaces with Proteins and Cells -- Chapter 6. Surface Modification of Tissue Engineering Scaffolds -- Chapter 7. Gradient Biomaterials and Their Impact on Cell Migration -- Chapter 8. Stem Cell Differentiation Mediated by Biomaterials/Surfaces -- Part III Regeneration of Some Clinic-Targeted Tissues -- Chapter 9. Cartilage Regeneration -- Chapter 10. Skin Regeneration -- Chapter 11. Regeneration of Blood Vessels -- Chapter 12. Cardiac repair and regeneration -- Chapter 13. Nerve Regeneration.
    Abstract: This book reviews state of the art of polymeric biomaterials for regenerative medicine and highlights advances in both fundamental science and clinical practice. It summarizes the latest techniques in polymeric scaffold fabrication, delivery carriers, physiochemical property modulation, as well as their influence on the adhesion and performance of biomolecules, cells, and tissues. It also describes methods for creating biofunctional surfaces/interfaces and subsequently modulating the host response to implantable materials. Lastly, it discusses the applications of biomaterials and constructs in soft-tissue regenerative medicine. It is a valuable resource for materials scientists and engineers wishing to identify research priorities to fulfill clinical needs and provides physicians with insights into emerging novel biomaterials. This integrated approach also offers engineering students a sense of the relevance of materials science in the development of novel therapeutic strategies. In the second edition, most of the chapters are updated according to the latest progress of this research field. A new chapter on nerve regeneration is also included.
    Type of Medium: Online Resource
    Pages: VIII, 577 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789819969487
    URL: https://doi.org/10.1007/978-981-99-6948-7
    DOI: 10.1007/978-981-99-6948-7
    DDC: 610.72
    Language: English
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    Heat Shock Proteins in Human Diseases (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Proteins . ; Cytology. ; Biomedical Research. ; Protein Biochemistry. ; Cell Biology.
    Description / Table of Contents: Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and Cancer Immunotherapy -- Chaperonin Hsp60 and Cancer Therapies -- Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment -- Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Therapeutics -- Multifaceted Roles of Heat Shock Factor 1 (HSF1) in Cancer -- Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer -- Heat Shock Proteins in Atrial Fibrillation -- Threading Microarrays into Novel Applications -- Regulation of Kaposi’s Sarcoma-associated Herpesvirus Biology by Host Molecular Chaperones -- Role of Heat Shock Factors in Diseases and Immunity -- Heat Shock Proteins and Pain -- Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway -- Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with diverse Cellular and Molecular Functions -- Roles of Heat Shock Proteins on Antigen Presentation -- Heat shock proteins mediate anastasis and plasticity of thermotolerant cells.
    Abstract: The book Heat Shock Proteins in Human Diseases provides the most comprehensive review on contemporary knowledge on the role of heat shock proteins (HSP) in various types of human diseases including cancer, cardiovascular disease, microbiology and inflammation. These diseases were specifically chosen due to their dismal prognosis, the survival benefit offered by the current standards do not greatly impact the overall survival statistics with the disease and are associated with toxicity. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in human diseases. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 297 p. 31 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030622893
    Series Statement: Heat Shock Proteins, 21
    URL: https://doi.org/10.1007/978-3-030-62289-3
    DOI: 10.1007/978-3-030-62289-3
    DDC: 610.72
    Language: English
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    New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Drug delivery systems. ; Regenerative medicine. ; Biomedical Research. ; Pharmacology. ; Drug Delivery. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Approaches Towards Synthetic Signal Transduction in Phospholipid Bilayers -- Development of Novel Versatile Theranostic Platforms Based on Titanate Nanotubes: Towards Safe Nanocarriers for Biomedical Applications -- Metal-organic Framework—Polymer Mixed-Matrix Membranes -- Insights into Adaptive Selforganized Supramolecular Structures from Molecular Modeling and Visualization -- Self-Assembled Metallacages as Drug Delivery Systems: Design Concepts and Challenge -- Functional Microporous Polymer Networks: Synthesis and Applications -- A Story on Carbon Dioxide and its Hydration -- Inverse Design and Hierarchical Multiscale Modelling of Biological Matter -- DNA-Directed Self-assembly of Macromolecular Structures -- Luminescent Complexes and their Assemblies : from Understanding to Artificial Virus -- Tailor-Made Polymers and Nanoparticles for Applications in Nanomedicine -- Squalene-based Nanomedicines : An Original and Efficient Approach for the Treatment of Neurological Disorders without Crossing the Blood-Brain Barrier -- Biodegradable Nanoparticles for Specific Drug Transport -- Multivalent rotaxanes designed as antibiofilm agents -- Measuring Ionic Transport through Lipid Bilayers -- Polymeric Carriers for Transporting Nucleic Acids - Contributions to the Field -- Smart Polymeric Materials for Drug Delivery -- Supramolecular Guanosine-quadruplex Hydrogels and Hydrogel Composites for Cell Growth Applications -- Hydrogelation of Chitosan with Monoaldehydes towards Biomaterials with Tuned Properties -- Inorganic Nanoarticles as Free Radical Scavengers -- A Microbiological Epilogue - Nosocomial Infections -- Molecular Dynamic Simulations and In Silico Analysis of Supramolecular Self-Assembled Structures -- Validation of the Non Toxicity of Non Viral Genetic -- Kinetics Transport of Ions/Water Through Nano-Scale Channels : Review And Update.
    Abstract: This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations. The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to treat the disease. Another interest concerns new ways to administer gene therapy. If genes are often delivered to their target cells by adapted viruses, the supramolecular non-viral ‘vectors’ using dynamic nano-frameworks and nano-structures are presented. In addition, it is important to reconstruct damaged tissues by mimicking natural processes in cells and polymers, such as tissue engineering and self-healing. Different options are here discussed: e.g. hydrogels based on chitosan, a carbohydrate polymer, are proving especially promising for tissue engineering and drug delivery. For controlled delivery of drugs or other biologically active compounds, hydrogels sensitive to the most important stimuli in the human body, such as temperature, pH, ionic strength, glucose and biomolecules released by the organism in pathological conditions have been developed. Finally, to assist and validate the experimental studies, computer modelling and simulations of large-sized molecular structures and systems using different molecular dynamics and quantum mechanical techniques are developed based on the experimental and chemistry synthesis. This book is of great interest for graduate students, researchers and health professionals interested in acquiring a better understanding of the mechanisms of medical treatments. In addition, it provides numerous tools to develop better therapies for human diseases.
    Type of Medium: Online Resource
    Pages: XII, 371 p. 174 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030574567
    URL: https://doi.org/10.1007/978-3-030-57456-7
    DOI: 10.1007/978-3-030-57456-7
    DDC: 610.72
    Language: English
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    Trends in Biomedical Research (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical care. ; Human physiology. ; Biomedical Research. ; Health Care. ; Human Physiology.
    Description / Table of Contents: Targeted Drug Delivery from Titanium Implants: A Review of Challenges and Approaches -- Reliability of Magnetic Resonance Tractography in Predicting Early Clinical Improvements in Patients with Diffuse Axonal Injury -- Integrated Thermal Rehabilitation: a New Therapeutic Approach for Disabilities -- The Cat Pet as a Source Intensification of Atopic Dermatitis -- Clinical Course and Outcome of Community Acquired Bacterial Meningitis in Cancer Patients -- Influence of Coping Strategy on Perception of Anxiety and Depression in Patients with Non-Small Cell Lung Cancer -- Inflammatory Markers during Continuous High Cut-Off Hemodialysis in Patients with Septic Shock and Acute Kidney Injury -- Body Composition and Biochemical Markers of Nutrition in Non-Dialysis Dependent Chronic Kidney Disease -- Biocompatibility of hemodialysis -- Decreasing Vaccination Coverage Rates against Hepatitis B and Tuberculosis in Newborns -- Virological and Epidemiological Situation in the Influenza Epidemic Seasons 2016/17 and 2017/18 in Poland -- Epidemic Influenza Seasons from 2008 to 2018 in Poland: A Focused Review of Virological Characteristics.
    Abstract: This book addresses hot issues in the research and management of difficult-to-treat medical disorders that are commonly encountered, but for which the underlying mechanisms are often unknown. These include the adverse effects of hemodialysis and its biocompatibility in chronic kidney insufficiency, particularly related to malnutrition and inflammation, or the vulnerability of cancer patients to bacterial meningitis, the infection that remains underdiagnosed due to limited expression of symptoms. The book also covers other key topics, such as the psychological care of lung cancer patients; difficulties in the diagnosis of diffuse axonal injury in traumatic brain injury – a disorder with a poor prognosis and high mortality rate; and the virological aspects of seasonal influenza epidemic outbreaks – a perennial modern scourge. Further, it addresses recent developments in targeted drug delivery from titanium implants and a novel integrated thermal approach to rehabilitation of neurodegeneration-related disabilities. Featuring the latest interdisciplinary trends in biomedicine, this book connects research, theory and practice to help alleviate suffering caused by a variety of diseases. It is a resource for medical professionals, including academics, practitioners and all allied healthcare workers.
    Type of Medium: Online Resource
    Pages: VI, 121 p. 25 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030412197
    Series Statement: Clinical and Experimental Biomedicine, 1251
    URL: https://doi.org/10.1007/978-3-030-41219-7
    DOI: 10.1007/978-3-030-41219-7
    DDC: 610.72
    Language: English
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    Deep Learning for Biomedical Data Analysis : Techniques, Approaches, and Applications (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Artificial intelligence. ; Bioinformatics. ; Biomedical Research. ; Artificial Intelligence. ; Bioinformatics.
    Description / Table of Contents: 1-Dimensional Convolution Neural Network Classification Technique for Gene Expression Data -- Classification of Sequences with Deep Artificial Neural Networks: Representation and Architectural Issues -- A Deep Learning Model for MicroRNA-Target Binding -- Recurrent Neural Networks Architectures for Accidental Fall Detection on Wearable Embedded Devices -- Medical Image Retrieval System using Deep Learning Techniques -- Medical Image Fusion using Deep Learning -- Deep Learning for Histopathological Image Analysis -- Innovative Deep Learning Approach for Biomedical Data Instantiation and Visualization -- Convolutional Neural Networks in Advanced Biomedical Imaging Applications -- Deep Learning for Lung Disease Detection from Chest X-Rays Images -- Deep Learning in Multi-Omics Data Integration in Cancer Diagnostic -- Using Deep Learning with Canadian Primary Care Data for Disease Diagnosis -- Brain Tumor Segmentation and Surveillance with Deep Artificial Neural Networks.
    Abstract: This book is the first overview on Deep Learning (DL) for biomedical data analysis. It surveys the most recent techniques and approaches in this field, with both a broad coverage and enough depth to be of practical use to working professionals. This book offers enough fundamental and technical information on these techniques, approaches and the related problems without overcrowding the reader's head. It presents the results of the latest investigations in the field of DL for biomedical data analysis. The techniques and approaches presented in this book deal with the most important and/or the newest topics encountered in this field. They combine fundamental theory of Artificial Intelligence (AI), Machine Learning (ML) and DL with practical applications in Biology and Medicine. Certainly, the list of topics covered in this book is not exhaustive but these topics will shed light on the implications of the presented techniques and approaches on other topics in biomedical data analysis. The book finds a balance between theoretical and practical coverage of a wide range of issues in the field of biomedical data analysis, thanks to DL. The few published books on DL for biomedical data analysis either focus on specific topics or lack technical depth. The chapters presented in this book were selected for quality and relevance. The book also presents experiments that provide qualitative and quantitative overviews in the field of biomedical data analysis. The reader will require some familiarity with AI, ML and DL and will learn about techniques and approaches that deal with the most important and/or the newest topics encountered in the field of DL for biomedical data analysis. He/she will discover both the fundamentals behind DL techniques and approaches, and their applications on biomedical data. This book can also serve as a reference book for graduate courses in Bioinformatics, AI, ML and DL. The book aims not only at professional researchers and practitioners but also graduate students, senior undergraduate students and young researchers. This book will certainly show the way to new techniques and approaches to make new discoveries.
    Type of Medium: Online Resource
    Pages: VI, 359 p. 130 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030716769
    URL: https://doi.org/10.1007/978-3-030-71676-9
    DOI: 10.1007/978-3-030-71676-9
    DDC: 610.72
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    Medical Visualization and Applications of Technology (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Anatomy. ; Medical education. ; Virtual reality. ; Augmented reality. ; Biomedical Research. ; Anatomy. ; Medical Education. ; Virtual and Augmented Reality.
    Description / Table of Contents: Part I. Healthcare -- Chapter 1. Is It Time to FONA Friend? A Novel Mixed Reality Front of Neck Access Simulator -- Chapter 2. “Learning About Skin Breakdown” – Design, Development and Evaluation of an Augmented Reality Application to Inform about Pressure Ulcers (sores) and Moisture Lesions -- Chapter 3. The Use of 3D-Printing and Injection Moulding in the Development of a Low-Cost, Perfused Renal Malignancy Model for Training of Robot-Assisted Laparoscopic Partial Nephrectomy -- Chapter 4. The Co-IMMUNicate App: An Engaging and Entertaining Education Resource on Immunity to Respiratory Viruses -- Part II. Education -- Chapter 5. Application of AR and 3D Technology for Learning Neuroanatomy -- Chapter 6. Communicative Powers of Interactive Digital Mediums in the Field of Polyomics -- Chapter 7. SkilletonVR: Canine Skeleton VR -- Chapter 8. Using Holograms to Engage Young People with Anatomy -- Chapter 9. The Digital Dolphin: Are 3D Mobile Based and Interactive Models a Useful Aid to Volunteers on Stranding Schemes Learning the Basic Anatomy and Pathology of Cetaceans? -- Chapter 10. The Impact of the COVID Crisis on Anatomical Education: A Systematic Review.
    Abstract: This edited book explores the use of technology to enable us to visualize the life sciences in a more meaningful and engaging way. It will enable those interested in visualization techniques to gain a better understanding of the applications that can be used in visualization, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualization techniques and technologies for the historical and forensic settings. The reader will be able to explore the utilization of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences. We have something for a diverse and inclusive audience ranging from healthcare, patient education, animal health and disease and pedagogies around the use of technologies in these related fields. The first four chapters cover healthcare and detail how technology can be used to illustrate emergency surgical access to the airway, pressure sores, robotic surgery in partial nephrectomy, and respiratory viruses. The last six chapters in the education section cover augmented reality and learning neuroanatomy, historical artefacts, virtual reality in canine anatomy, holograms to educate children in cardiothoracic anatomy, 3D models of cetaceans, and the impact of the pandemic on digital anatomical educational resources.
    Type of Medium: Online Resource
    Pages: IX, 323 p. 270 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031067358
    Series Statement: Biomedical Visualization, 1
    URL: https://doi.org/10.1007/978-3-031-06735-8
    DOI: 10.1007/978-3-031-06735-8
    DDC: 610.72
    Language: English
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    Career Options in the Pharmaceutical and Biomedical Industry : An Insider’s Guide (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Vocational guidance. ; Career education. ; School management and organization. ; School administration. ; Biomedical Research. ; Career Counseling. ; Career Skills. ; Organization and Leadership.
    Description / Table of Contents: Part 1: Setting the scene -- Chapter 1: Life after Academia: Launching your Pharma/Biotech Career -- Chapter 2: Competences for Pharmacists -- Chapter 3: Job and Career Opportunities in the Pharmaceutical Industry: An Overview -- Part 2: Opportunities along the drug/product life cycle -- Chapter 4: Career Opportunities in Toxicology -- Chapter 5: Job Possibilities in Clinical Research -- Chapter 6: How to Get and Develop a Career in a Market Access Role in the Medical Devices Industry -- Chapter 7: Job Opportunities in Pharmaceutical Marketing -- Chapter 8: Working in Medical Affairs and Clinical Operations: Life-Changing Careers -- Chapter 9: The Role of Medical Science Liaison -- Chapter 10: Career Development for Physicians in the Biopharmaceutical Industry -- Part 3: Opportunities in Supportive Functions -- Chapter 11: Job and Career Opportunities in Regulatory Affairs/Science -- Chapter 12: Job Opportunities in Clinical Research Quality Assurance -- Chapter 13: Job Opportunities in Quality Assurance Related to Manufacturing of Medicinal Products -- Part 4: Other Opportunities in the Pharmaceutical and Biomedical Sector -- Chapter 14: Careers Perspective in a Science and Technology Park -- Chapter 15: To be or not to be: Entrepreneurship and Enterprise Creation as a Way to Innovate in Life Sciences -- Chapter 16: How to Become a Successful Hospital and Community Pharmacist -- Part 5: Practical tips and tricks -- Chapter 17: A Successful Career in the Life Sciences Industry: How to Write your Strongest Resumé and Ace that Interview -- Chapter 18: Skill Building for Career Advancement: Public Speaking and Networking -- Chapter 19: Training Opportunities for a Career in the Pharmaceutical and Biomedical Industry/Sector.
    Abstract: Written by dedicated and active professionals from different areas of the pharmaceutical, biomedical, and medtech sectors, this book provides information on job and career opportunities in various life sciences industries. It also contains useful tips to launch your own startup. The pharmaceutical, biomedical and medical technology sectors offer a wide range of employment opportunities to talented and motivated young graduates. However, many of these employment prospects are not well known to early career scientists, who concentrate primarily on the scientific and academic content of their fields of interest. The book is divided into five parts: Part 1 provides an academic perspective that focuses on the specific preparation required in the final years of study to embark on a successful career in the pharmaceutical and biomedical industries. In Part 2, industry experts discuss employment possibilities all along the drug or product life cycle, from discovery research and development to commercialisation. Part 3 follows, highlighting opportunities in support functions such as regulatory affairs or quality assurance. Part 4 focuses on additional opportunities in the wider biomedical sector, while Part 5 contains practical tips and training opportunities for entering the pharmaceutical and biomedical industries. In the epilogue, the authors reflect on this fascinating field and its career prospects. The book offers a multidisciplinary perspective on career opportunities in the pharmaceutical and biomedical industry to a wide range of students and young life scientists. .
    Type of Medium: Online Resource
    Pages: XXI, 328 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031149115
    URL: https://doi.org/10.1007/978-3-031-14911-5
    DOI: 10.1007/978-3-031-14911-5
    DDC: 610.72
    Language: English
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    Tuberculosis : Integrated Studies for a Complex Disease (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Clinical medicine Research. ; Epidemiology. ; Diseases Causes and theories of causation. ; Biomedical Research. ; Clinical Research. ; Epidemiology. ; Pathogenesis.
    Description / Table of Contents: 1. Introduction on Tuberculosis: Integrated Studies for a Complex Disease -- 2. Global Tuberculosis Epidemiology -- 3. Heterogeneity in Tuberculosis -- 4. The Unequivocal Relationship between Tuberculosis and Tobacco: Integration of Two Maladies -- 5. Relationship between Pre-existing Cancer and Tuberculosis -- 6. Laboratory Diagnosis of Tuberculosis -- 7. The Role of Diagnostic Microdevices in the Fight Against Tuberculosis -- 8. Immunodiagnostics of Tuberculosis: Recent Discoveries -- 9. Role of Bronchoscopy in Diagnostics and Treatment of Tuberculosis -- 10. Diagnosis of Childhood Tuberculosis in Low- and Middle-income Countries -- 11. Pediatric Tuberculosis: Current Evidence for Laboratory Diagnosis -- 12. A Multidisciplinary Approach Towards Finding and Treating All Tuberculosis Patients -- 13. Chemotherapy for Drug-Susceptible Tuberculosis -- 14. The Pharmacokinetic and Pharmacodynamic Properties of Antitubercular Medications -- 15. Immune Approaches In Tuberculosis Treatment -- 16. Inhalation Therapy in Pulmonary Tuberculosis -- 17. Role of Micronutrients in Tuberculosis Management -- 18. Drug Resistance in Tuberculosis: Mechanisms, Diagnosis, New Responses, and the Need for An Integrated Approach -- 19. Resistance in Tuberculosis: Molecular Mechanisms and Modulation -- 20. Personalized Tuberculosis Care for Drug-Resistant Tuberculosis -- 21. Important Targets and Inhibitors of Mycobacterium Tuberculosis -- 22. P-type ATPases: A Relevant Component in Mycobacterium tuberculosis Viability -- 23. The Challenges of Antitubercular Drug Discovery -- 24. Exploring Decaprenylphosphoryl-β-D-ribose 2’-Epimerase 1 (DprE1): A Target for Anti-Tubercular Drugs -- 25. Energy Pathways in Mycobacterium Tuberculosis -- 26. Drug Discovery for Non-Tuberculous Mycobacteria: Recent Updates -- 27. Challenges for Contact Tracing and Tuberculosis Preventive Therapy Scale-up -- 28. Exploring Problematizations Underlying Tuberculosis Control Strategies: A Cross-Country Analysis of India and Kenya -- 29. Challenges in Prevention and Management of Tuberculosis -- 30. Tuberculosis in Contacts and Healthcare Workers -- 31. Tuberculosis Among People Who Use Drugs: Multilevel Considerations for Prevention, Diagnosis, and Treatment -- 32. Anti-Tumor Necrosis Factor-α Antagonists and Tuberculosis -- 33. Breast Tuberculosis -- 34. Central Nervous System Tuberculosis: Pathogenesis, Diagnosis, and Management -- 35. Pleural Tuberculosis -- 36. Ocular Tuberculosis -- 37. Ocular Tuberculosis: Biomarkers for Risk Stratification -- 38. Bone and Joint Tuberculosis -- 39. Abdominal Tuberculosis: Pathogenesis, Clinical Features, and Diagnosis -- 40. Bovine Tuberculosis at The Interface of Cattle, Wildlife, and Humans -- 41. Evolution and Molecular Characteristics of Mycobacterium Tuberculosis and Mycobacterium Bovis -- 42. Animal Tuberculosis: Gross Lesions and Anatomopathological Diagnosis -- 43. Estimation of Microbial Mutation Rates in Tuberculosis Research -- 44. The Role of Epigenetics in the Development of Anti-Tuberculosis Drug Resistance -- 45. Multiomics Integration of Tuberculosis Pathogenesis -- 46. Lung Microbiome in Tuberculosis -- 47. The Correlation of Microbiota and Host Epigenome in Tuberculosis -- 48. The Pathogenesis and Progression of Sarcoidosis from The Standpoint of Tuberculosis -- 49. Tuberculosis: A Historical and Global Bioethical Perspective -- 50. The Problem of Tuberculosis: Myths, Stigma, and Mimics -- 51. Tuberculosis: Integrated Studies for a Complex Disease 2050.
    Abstract: Tuberculosis have been documented since antiquity and the search of the microbes that cause this disease started more than three hundred years ago. Nevertheless, tuberculosis remains an important global health issue, with millions of people affected per year in addition to millions that remain undiagnosed and untreated. Patients with tuberculosis face the full range of recurrence, reinfection, and resistance due to diagnostic, prophylactic, and therapeutic procedures that are not as effective as they should be. In addition, variability in susceptibility to tuberculosis pose a complex problem with numerous interrelated variables. This volume is devoted to the understanding of Tuberculosis focusing on its heterogeneity, its transmission, manifestations, related conditions, diagnosis, treatments, drug resistance and prevention.
    Type of Medium: Online Resource
    Pages: XXIV, 1116 p. 363 illus., 239 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031159558
    Series Statement: Integrated Science, 11
    URL: https://doi.org/10.1007/978-3-031-15955-8
    DOI: 10.1007/978-3-031-15955-8
    DDC: 610.72
    Language: English
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    Microbial Engineering for Therapeutics (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Biomedical engineering. ; Industrial microbiology. ; Bioinformatics. ; Synthetic Biology. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Industrial Microbiology. ; Computational and Systems Biology. ; Synthetic Biology.
    Description / Table of Contents: Part 1 Introduction to Microbial Engineering -- 1 Exploring the Potential of Microbial Engineering: The Prospect, Promise and Essence -- Part 2 Microbial Engineering Approaches -- 2 Role of System Biology in Microbial System -- 3 Synthetic Biology: Refining Human Health -- 4 Probiotic Engineering: A focus on Inflammatory Bowel Disease -- 5 Engineering microbes for smart diagnostics & Lab on Chip -- 6 Bacteriophage and Virus Engineering -- 7 CRISPR Technologies: A tool for Engineering Microbes -- Part 3 Health Benefits -- 8 Recombinant Vaccines: The Revolution Ahead -- 9 Microbe-Host Metabolic Interaction- Probiotic Approach -- 10 Designer Microbes: Oncotherapy approach -- 11 The human gut microbiome in health, disease and therapeutics -- 12 Use of Engineered Bacteria for Production of Green Chemicals & Pharmaceuticals -- 13 Fat Fighting Microbes. Part 4 Innovation & Translation -- 14 Scale-up of engineering strain for industrial applications -- 15 Affordable therapeutics through Engineered Microbes -- 16 COVID-19: Lesson Learnt from Diagnostics to therapeutics. .
    Abstract: This book highlights the recent advances in the field of microbial engineering and its application in human healthcare. It underscores the systemic and synthetic biology approaches for engineering microbes and discusses novel treatments for inflammatory bowel diseases based on engineered probiotics. The book also reviews the different options and methods for engineering microbes, ranging from recombinant DNA technology to designing microbes for targeting specific sites and delivering therapeutics. Further, it discusses genetically engineered microorganisms for smart diagnostics and describes current approaches in microbial gene editing using CRISPR-Cas9-based tools. Lastly, it summarizes the potential applications of human microbiome engineering in improving human health and explores potential strategies for scaling-up the production of engineered microbial strains for commercial purposes, as well as the challenges. Given its scope, this book is a valuable resource for students, researchers, academics and entrepreneurs interested in understanding microbial engineering for the production of commercial products.
    Type of Medium: Online Resource
    Pages: XI, 374 p. 45 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811939792
    URL: https://doi.org/10.1007/978-981-19-3979-2
    DOI: 10.1007/978-981-19-3979-2
    DDC: 610.72
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    Nanomaterials and Biomedicine : Therapeutic and Diagnostic Approach (2020)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Nanotechnology. ; Immunology. ; Human physiology. ; Stem cells. ; Biomedical Research. ; Nanotechnology. ; Immunology. ; Human Physiology. ; Stem Cell Biology.
    Description / Table of Contents: Chapter 1_Introduction to NanoScience, NanoTechnology, and NanoParticles -- Chapter 2_NanoScience and Bioprospecting -- Chapter 3_Nanomaterials and their use in Biomedicine -- Chapter 4_Nano scaffolds and Tissue Engineering -- Module 5_NanoScience Research in Regenerative Medicine -- Chapter 6_Nanomaterials in Food: Probiotics -- Chapter 7_Eco-compatible Single format Nanobioantibody -- Chapter 8_ NanoScience and DNA barcoding.
    Abstract: This book comprehensively reviews the history of nanotechnology, and describes the physiochemical properties of various nanoparticles and their biomedical applications. Covering the biotoxicity of nanoparticles, their bio-distribution and release kinetics, and their role in diagnosis, pre-clinical drug discovery and disease prevention, it also examines the application of nanoscaffolds in tissue engineering and as cell culture templates. Further, the book discusses several fabrication methodologies for regenerative medicine, and explores nanotechnology-based stem cell therapeutics, including stem cell transfection, stem cell delivery, and stem cell expansion for promoting tissue regeneration. Lastly, it addresses the use of DNA barcoding technology from nanosamples for the detection, identification and validation of emerging pathogens, biodiversity and ancient remnants of living specimens, and highlights various strategies for the plant-mediated synthesis of nanoparticles. Given its scope, it is a valuable reference resource for graduate students and researchers interested in understanding the diverse range of biomedical applications of nanoparticles. .
    Type of Medium: Online Resource
    Pages: XVIII, 134 p. 13 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811552748
    URL: https://doi.org/10.1007/978-981-15-5274-8
    DOI: 10.1007/978-981-15-5274-8
    DDC: 610.72
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    Handbook of Millets - Processing, Quality, and Nutrition Status (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Food science. ; Agriculture. ; Biomedical Research. ; Food Science. ; Agriculture.
    Description / Table of Contents: Chapter 1. Millets-an Overview -- Chapter 2. Millet Cultivation an Overview -- Chapter 3. Millet Storage and Pest Management -- Chapter 4. Major Millets Processing -- Chapter 5. Minor millet processing and its impacts on composition -- Chapter 6. Chemistry of Millets: Major and Minor Constituents -- Chapter 7. Nutritional properties of millets: neglected cereals with potentials to combat malnutrition -- Chapter 8. Post-harvest Treatments and Storage of millets -- Chapter 9. Millet Milling Technologies -- Chapter 10. Effect of Processing on Functional Characteristics, Physiochemical Properties, and Nutritional Accessibility of Millets -- Chapter 11. Emerging Technologies in Millet Processing -- Chapter 12. Millet Food Products -- Chapter 13. Byproducts from Millet Processing Industry -- Chapter 14. Quality Standards for Millets -- Chapter 15. Millet Industry Scenario -- Chapter 16. Toxins in Millets.-.
    Abstract: The book offers an updated perspective on the unique characteristics of millets. Millets are consumed for their health/nutritional benefits, and in the preparation of specialty foods for target groups – from pediatrics to geriatrics. Recent trends suggest the importance of millet in the human diet due to their nutritional importance, ability to grow in high temperatures and drought conditions, and their resistance to pests and diseases. This book highlights different types of millet and discusses their properties as well as nutritional and anti-nutritional values. In addition, the book also provides information on the physiochemical properties, future prospects, current methodologies, and agricultural practices. The last few parts cover the emerging technologies in millet processing, by-products utilization, quality standards, and the current millet industry scenario. The book provides a comprehensive overview of the status of millet processing, quality, and nutraceutical product manufacture. The book is a resourceful read for students and researchers in food sciences, as well as industry experts.
    Type of Medium: Online Resource
    Pages: VII, 386 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811672248
    URL: https://doi.org/10.1007/978-981-16-7224-8
    DOI: 10.1007/978-981-16-7224-8
    DDC: 610.72
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    Polymeric nanoparticles for the treatment of solid tumors (2022)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Nanotechnology. ; Cancer Treatment. ; Biomedical Research. ; Nanotechnology. ; Cancer Therapy.
    Description / Table of Contents: Chapter 1. The tumor microenvironment -- Chapter 2. Methods of formulation of polymeric nanoparticles -- Chapter 3. Natural polymers based nanoparticles targeted to solid tumors -- Chapter 4. Optimization of physicochemical properties of polymeric nanoparticles for targeting solid tumors -- Chapter 5. Passive and active targeting approaches for solid tumors -- Chapter 6. Polymeric nanoparticles entrapping natural drugs for cancer therapy -- Chapter 7. Polymeric nanoparticles entrapping drug combinations targeted to solid tumors -- Chapter 8. Ligands specific to over-expressed receptors in solid tumors -- Chapter 9. Ligand targeted polymeric nanoparticles for cancer chemotherapy -- Chapter 10. Polymeric nanoparticles as theranostics for targeting solid tumors -- Chapter 11. Oral delivery of polymeric nanoparticles for solid tumors -- Chapter 12. Polymeric nanoparticles to target glioblastoma tumors -- Chapter 13. Polymeric nanoparticles to target lung cancer -- Chapter 14. Polymer based nanoplatforms for targeting breast cancer -- Chapter 15. PH-Sensitive polymeric nanoparticles for cancer treatment -- Chapter 16. Polymeric nanoplatforms for targeted treatment of prostate cancer -- Chapter 17. Cellular internalization and toxicity of polymeric nanoparticles -- Chapter 18. Prospects and challenges in the treatment of solid tumors.
    Abstract: This book focuses on the emerging research in the field of treatment of solid tumors or cancer with new drug delivery systems using nanotechnology. Nanotechnology has given us a good scope for development of new innovative drug delivery strategies to increase the therapeutic efficacy of anticancer drugs with reduced off-target side effects. Cancer is one of the main causes of death worldwide due to the limitations of classical therapies such as low solubility of active drugs, toxic side effects on healthy cells and resistance of tumor cells. These issues are partly solved by the recent development of polymeric nanoparticles, which improve drug absorption and the therapeutic index, while reducing side effects. Drug carriers must be biocompatible, biodegradable and non-immunogenic. Coupled to a ligand that has affinity for that particular cell, polymeric nanoparticles are used to target specifically malignant cells or tissues and, in turn, improve drug stability. This book presents the latest advances in the application of polymeric particles for cancer treatment, with focus on the tumor microenvironment, synthesis, active and passive targeting, patents, targeting over-expressed receptors, tumor-targeting ligands, theranostics, glioblastoma tumors, lung cancer, breast cancer, prostate cancer and pH-responsive nanoparticles.
    Type of Medium: Online Resource
    Pages: X, 512 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031148484
    Series Statement: Environmental Chemistry for a Sustainable World, 71
    URL: https://doi.org/10.1007/978-3-031-14848-4
    DOI: 10.1007/978-3-031-14848-4
    DDC: 610.72
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    Integrated Science of Global Epidemics (2023)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Public health. ; Epidemiology. ; Medical policy. ; Medicine, Preventive. ; Health promotion. ; Biomedical Research. ; Public Health. ; Epidemiology. ; Health Policy. ; Health Promotion and Disease Prevention.
    Description / Table of Contents: Introduction on Integrated Science of Global Epidemics -- Emerging Viral Infections in Human Population -- One Health as An Integrated Approach: Perspectives from Public Services for Mitigation of Future Epidemics -- Multipronged Approach to Combat COVID-19: Lessons from Previous Pandemics for the Future -- Response to Disease Outbreaks in Africa: A Call to Build Resilient Health Systems -- Navigating Global Public Influenza Surveillance Systems for Reliable Forecasting -- Three Respiratory Syndrome Epidemics (SARS, MERS, COVID-19) in Two Decades: Clinical Epidemiological Considerations -- Epidemic in Complex Networks and Some Ideas About the Impact of Isolation Strategies in the Context of the COVID-19 Pandemic -- Optimal Control: Application and Applicability in Times of Pandemics -- Analysis of A COVID-19 Model Implementing SocialDistancing as An Optimal Control Strategy -- Impact of Policy Implementations on the Propagation of COVID-19 Before Vaccine -- Environmental Factors Associated with Global Pandemic Transmission and Morbidity -- Urbanization and the Epidemiology of Infectious Diseases: Towards the Social Framing of Global Responses -- Pandemics and Mass Casualties: Cornerstones of Management -- Social Marketing Contributions to Mitigate Global Epidemics -- The Significance of Super Intelligence of Artificial Intelligence Agencies in the Social Savageries of COVID-19: An Appraisal -- Integration of Sex and Gender Approaches in National Ethics Committees’ Mandate to Appraise COVID-19 Research Protocols: Lessons from West Africa -- Psychology, Law, Ethics, Telehealth, and the Global Pandemic -- Physical Inactivity, Sedentarism, and Low Fitness: A Worldwide Pandemic for Public Health -- The Global Epidemic of Diabesity: Are We Heading for An Unsustainable Future? -- Nutrition, Function, and Quality of Life in Older Adults Socially Isolated Due to the COVID-19 Pandemic: A Focus on Telehealth Interventions -- Africa’s Response to Pandemics -- Vaccine Hesitancy and Refusal: History, Causes, Mitigation Strategies -- Vaccine Compliance versus Trust in a Pandemic -- Child Development in A Crisis: A Pandemic -- HIV/AIDS Problems and Policies in Adolescent Population -- Addressing Needs of Foreign Schoolchildren to Combat a Global Epidemic of Dengue Virus Infection: Transnational and Trans-sectoral Initiatives -- Integrated Science of Global Epidemics 2050.
    Abstract: The “Integrated Science of Global Epidemics” is the new proposed volume of Integrated Science Book series, aiming to publish the results of the most updated ideas and reviews on Global Epidemics. The whole world is suffering from complex problems, border less problems and global solution should be developed. The Integrated Science of Global Epidemics aims to highlight the combination of different disciplines, including formal sciences, physical-chemical sciences and engineering, biological sciences, medical sciences, and social sciences, to deal with complex problems such as global epidemics. This contributed volume could be used as guidelines for the entire scientific community and policy makers to successfully face these global threats. Chapter 27 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 623 p. 170 illus., 144 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031177781
    Series Statement: Integrated Science, 14
    URL: https://doi.org/10.1007/978-3-031-17778-1
    DOI: 10.1007/978-3-031-17778-1
    DDC: 610.72
    Language: English
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    XIIIth International Symposium on Spermatology (2021)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Urology. ; Reproductive health. ; Biomedical Research. ; Urology. ; Reproductive Medicine.
    Description / Table of Contents: Section I – Introduction to Spermatology Symposium -- Chapter 1. The XIIIth International Symposium on Spermatology -- Chapter 2. Fifty Years of the Spermatology Symposium -- Chapter 3. Spermatology in Sweden -- Section II – Are Sperm at the Verge of Extinction? -- Chapter 4. Temporal trends in human sperm counts: Findings and implications -- `Chapter 5. Is Decreasing Sperm Concentrations a Sign of a General Decay in Fertility Potential? -- Chapter 6. Environmental toxicants and sperm production in men and animals -- Section III – Sperm DNA – protection and delivery of a complete and undamaged genome? -- Chapter 7. Post-testicular sperm DNA oxidation: what to be afraid of? -- Chapter 8. Sperm as a possible source of transgenerational epimutations and genetic instability -- Chapter 9. Complex population of chromatin-associated proteins identified in mature sperm of the European sea bass (Dicentrarchuslabrax) through high-throughput proteomic analysis -- Chapter 10. Does Cinnamtannin B-1 protects or destabilize sperm DNA? Contradictory results of SCSA® and TUNEL Invited presentations -- Chapter 11. Peripubertal serum dioxin concentrations and sperm methylome of young Russian adults -- Chapter 12. Sperm DNA fragmentation in human split ejaculates -- Section IV - Sperm Competition, Evolution and Sperm-Egg Interaction -- Chapter 13. The sexual cascade: evolutionary dynamics of sperm competition -- Chapter 14. Genotype-phenotype associations in relation to evolution of sperm form and function -- Chapter 15. From mouse to human: New aspects of sperm transport and fertilization using cutting edge technologies -- Chapter 16. First Snapshot of How Sperm Binds the Egg at the Molecular Level -- Chapter 17. The Typical and Atypical Centrioles and Their Potential Roles in the Sperm and Embryo -- Chapter 18. Adaptive modifications of the regulation of sperm motility in the diversification of reproductive modes of amphibians -- Section V - Genetic aspects of sperm production and performance and its effects on the offspring -- Chapter 19. When cilia go bad - the complex genetics of ciliopathies -- Chapter 20. Within-Ejaculate Sperm Selection and its Implications for Assisted Reproduction Technologies -- Chapter 21. Requirements for informative and robust computational measures of sperm motility -- Chapter 22. Effect of cryopreservation on the genome of sperm in animal and humans -- Chapter 23. Mutations in the CFAP-coding Genes Lead to Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella -- Chapter 24. The mouse-specific Gly-to-Cys mutation in mammalian acrosin is a cause of impairment in proteolytic activity -- Chapter 25. Chemical and genetic approaches to identify C. elegans spermiogenesis-related factors -- Section V -CASA - Advances and Challenges -- Chapter 26. CASA in the clinical andrology laboratory -- Chapter 27. Process and Data Management of Casa in Animal Spermatozoa -- Chapter 28. Relationship between flagellar movement and head trajectory at higher frame rates-is this still a valid approach for CASA? -- Chapter 29. CASA a Suitable tool for epidemiology and reprotox studies -- Section VI -Challenges for Sperm Function In Vitro -- Chapter 30. Common challenges for sperm in vitro- causes and consequences -- Chapter 31. Main effects of in vitro manipulation of spermatozoa -- Chapter 32. Effect of Melatonin on Capacitation and Ca2+ Distribution in Red Deer Spermatozoa -- Chapter 33. Unravelling the signal transduction pathways of novel mitochondrial peroxiporins in activated piscine spermatozoa -- Chapter 34. Prolonged chilled preservation and preliminary investigations of energy production of koala (Phascolarctos cinereus) spermatozoa -- Chapter 35. Sperm motion and metabolism in physiological conditions -- Chapter 36. Gametes collision in fresh water fish: evidences of guidance and selection -- Chapter 37. Lectin-binding pattern changes on the bovine sperm after differently induced process of capacitation -- Section VII -Heterogeneity of Sperm Morphology and Laboratory Techniques to Overcome Assessment Challenges -- Chapter 38. Have we conquered sperm morphology analysis in different mammalian species as analysed by CASMA? -- Chapter 39. Progress with sperm morphology evaluation after the strict criteria prognosis groups era due to the introduction of the new lower reference limit values for semen parameters of the 2010 WHO manual -- Chapter 40. A structured assessment for the assessment of human sperm morphology -- Chapter 41. On the Indispensability for Standardization of the Basic Examination of Human Semen -- Chapter 42. A simple but dramatic technical improvement in the Diff Quik stain protocol used for preparing specimens for sperm morphology evaluation (Improved Diff Quik stain protocol for preparation of sperm morphology evaluation specimens) -- Section VII - Fertility and Infertility -- Chapter 43. Intracellular Viruses Identification in Sperm Assay of Patients with Fertility problems -- Chapter 44. Association between vitamin D intake and vitamin D status with semen parameters among young men in Southern Spain -- Chapter 45. Single cell analysis of intracellular calcium signalling of patient sperm and its relation to IVF success -- Chapter 46. Sperm from a patient with a homozygous in-frame deletion in CATSPERE lack functional CatSper expression and fail to fertilise at IVF -- Chapter 47. Changes in pattern of protein phosphorylation in bull testicular and epididymal sperm -- Chapter 48. Proteomics and biomarker identification in improved sperm motility parameters after 4 h of ejaculatory abstinence -- Chapter 49. HSP90A may control spermatogenesis of Asian elephant (Elephas maximus) cryptorchid testes -- Chapter 50. Improved sperm function in human sperm subpopulations: a model for studying subfertility -- Chapter 51. Absence of BSP protein have not important effect on male infertility. .
    Abstract: This Symposium had 7 main themes with invited speakers, 17 free oral presentations and 44 poster presentations. Morning sessions were separated from afternoon sessions by a two-hour lunch break to inspire to spontaneous interaction between participants. The long, bright evenings of early May with a generous weather also contributed to the intended atmosphere of scientific and social interchange. Themes Are Sperm at the Verge of Extinction? Sperm DNA – protection and deliv­ery of a complete and undamaged genome Sperm Competition, Evolution and Sperm-Egg Interaction Genetic aspects of sperm production and performance and its effects on the offspring CASA - Advances and Challenges Challenges for Sperm Function In Vitro Heterogeneity of Sperm Morphology and Laboratory Techniques to Overcome Assessment Challenges Sperm Motility (Free Poster Theme) Fertility and Infertility (Free Poster Theme).
    Type of Medium: Online Resource
    Pages: X, 370 p. 72 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030662929
    URL: https://doi.org/10.1007/978-3-030-66292-9
    DOI: 10.1007/978-3-030-66292-9
    DDC: 610.72
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    Grant writing for medical and healthcare professionals (2023)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Research Methodology. ; Clinical medicine Research. ; Biomedical Research. ; Research Skills. ; Clinical Research.
    Description / Table of Contents: Section I: Understanding Grant Writing: What is your Aim (Ambition-Interest-Mission), and what you want to do -- What is a grant? How to prepare for writing a grant proposal application -- Funders Perspective: What the funding body expects from researchers? -- Funding organizations for science and healthcare -- Obtaining letters of support -- Section II: The process for grant writing: Writing a Grant Proposal for a Single Centre Study: step-by-step approach -- Budgeting the project-detailing the required funding and expenditure -- Proving the competency of the researcher and the adequacy of the infrastructure to carry out the research -- Agreement and MOU – ethical and legal aspects of funding for healthcare research -- Write an impressive cover page (Covering letter) and abstract for the grant proposal application -- Surveillance plan and site visit – Roles and rights of the researcher and the funding agency -- Sources of funding and acknowledgment – Good Clinical Practice Guidelines -- Writing a grant proposal for a Collaborative study -- Checklist for grant proposal – Mandatory elements -- Tips for improvising the chance of getting the grant -- Dealing with The Rejected Grant Proposal- Learning From The Mistakes -- Section III: Grant writing for specific regional funding organizations: Preparing a grant proposal for medical research in the UK -- Preparing a grant proposal for the USA -- Preparing a Grant Proposal for Australia -- Proposal Writing for Grant Application in Malaysia -- Grant writing for other Asian countries.
    Abstract: Conducting research requires resources to meet the research need. The resources in the research institutes/ centers are often inadequate, limiting the research outcome. Research grants help overcome those limitations and help the researchers carry out quality research without any restriction. Grant proposal writing is an essential skill to be mastered by every researcher. However, the majority of the medical schools, except the few research institutes, do not have a structured learning module for obtaining grants. On most occasions, the skill of writing grant proposals goes by self-learning. For students, it is burdening due to the tremendous time consumed to learn the craft of writing the grant proposal and the exhausting clinical and academic work. This book is carefully prepared to keep in mind the difficulties faced by the young researchers and the students concerning choosing a funding agency, grant makers' expectations, budgeting, surveillance and site visits, rights of the researcher and the funding agency, and ethical and legal aspects of obtaining the grant. The book also covers the alternate plan for partial funding or interruption of the financing, reporting the source of funding and acknowledgment, good clinical practice guidelines, and dealing with the rejected grant proposal. The research projects are often dropped or modified extensively due to the limited resources in the existing facility. The researchers are forced to compromise the research objective due to expensive requirements. There is a shortage of awareness regarding the availability of funding and grant for the conduct of research. Even if the researchers are aware of obtaining the financing, there is a lack of training in grant proposal writing, which is essential in getting the research funding. This book on grant proposal writing for medical and healthcare professionals covers such difficulties and deficiencies. It will provide complete companionship from knowing the funding agency to obtaining the grant. .
    Type of Medium: Online Resource
    Pages: XX, 247 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811970184
    URL: https://doi.org/10.1007/978-981-19-7018-4
    DOI: 10.1007/978-981-19-7018-4
    DDC: 610.72
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    Medical Research and Innovation (2021)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Respiratory organs Diseases. ; Respiratory organs. ; Physiology. ; Immunology. ; Inflammation. ; Biomedical Research. ; Pneumology. ; Respiratory Physiology. ; Immunology. ; Inflammation.
    Description / Table of Contents: Overload of Medical Documentation: A Disincentive for Healthcare Professionals -- Epidemiologic Benefits of Pneumococcal Vaccine Introduction into Preventive Vaccination Programs -- Serum Vitamin D and Immunogenicity of Influenza Vaccination in the Elderly -- Influenza A (H1N1) and Respiratory Syncytial Virus (RSV) Coinfection in a Newborn Child: A Case Report -- Thoracic Manifestation of Granulomatosis with Polyangiitis: A Case Report -- The Natural Course of Impaired Fasting Glucose -- Oleosins: A Short Allergy Review -- Shortage of Physicians: A Critical Review -- Fluid Therapy in Patients Undergoing Abdominal Surgery: A Bumpy Road Towards Individualized Management -- Manual Pressure Release and Low-Grade Electrical Peripheral Receptor Stimulation in Nonspecific Low Back Pain: A Randomized Controlled Trial -- Human Inhalation Study with Zinc Oxide: Analysis of Zinc Levels and Biomarkers in Exhaled Breath Condensate. Cognitive Function After Lung Transplantation.
    Abstract: This volume is dedicated to multidisciplinary research at the interface between basic biomedicine and clinical practice. This book guides best practice in the diagnosis and therapy while dealing with difficult-to-treat disorders of yet unclear etiology. Chapters address such disorders as granulomatosis with polyangiitis causing autoimmune-related multiorgan inflammation of blood vessels, increasingly widespread allergy to peanuts, occupational exposure to zinc oxide, and immunogenic responses to pneumococcal and influenza vaccination underlying their preventive effectiveness. Other hot issues deal with the proper use of fluid therapy in the perioperative period and a cognitive decline in lung transplant patients. A new physiotherapeutic approach of treating key myofascial trigger points in low-back pain appears highly beneficial in reducing patients’ disability, advancing physiotherapy of this overwhelming condition. Finally, other chapters consider ways to streamline medical management to increase the number of physicians and their availability for patients, a particularly sensitive issue in the current COVID-19 pandemic. The dissemination of clinical knowledge about high-risk and hardly controllable conditions is an inalienable part of progress in medical practice. The book is a resource for clinical specialists, general practitioners, and allied healthcare professionals.
    Type of Medium: Online Resource
    Pages: VI, 101 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030702069
    Series Statement: Clinical and Experimental Biomedicine, 1324
    URL: https://doi.org/10.1007/978-3-030-70206-9
    DOI: 10.1007/978-3-030-70206-9
    DDC: 610.72
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    Hair Follicle Regeneration (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Stem cells. ; Biotechnology. ; Biomedical Research. ; Stem Cell Biology. ; Biotechnology.
    Description / Table of Contents: Chapter 1. The historical studies underpinning the concept of hair follicle neogenesis (Higgins C, Jahoda C) -- Chapter 2. Hair regeneration and rejuvenation: pipeline of medical and technical strategies (Limbu S, Kemp P) -- Chapter 3. Cells and structures involved in hair follicle regeneration: an introduction (Tsai J, Garza LA) -- Chapter 4. The dermal papilla and hair follicle regeneration: Engineering strategies to improve dermal papilla inductivity (Pantelireis N, Clavel C) -- Chapter 5. Dermal sheath and hair follicle regeneration (Yoshida Y, Tsuboi K, Kishimoto J) -- Chapter 6. Epithelial-mesenchymal interactions between hair follicles and dermal adipose tissue (Ramos R, Plikus MV) -- Chapter 7. Lymphatic vasculature and hair follicle regeneration (Cazorla A, Perez-Moreno M) -- Chapter 8. In vitro and ex vivo hair follicle models to explore therapeutic options for hair regeneration (Bertolini M, Piccini I, McElwee KJ) -- Chapter 9. Extracellular vesicles including exosomes for hair follicle regeneration (Aberdam E, le Riche A, Bordes S, Closs B, Park BS, Aberdam D) -- Chapter 10. Stem cell-based therapies for hair loss: what is the evidence from a clinical perspective? (Park BS, Choi HI) -- Chapter 11. Induced pluripotent stem cell approach for hair follicle regeneration (Pinto A, Terskikh AV) -- Chapter 12. Biofabrication technologies in hair neoformation (Abreu CM, Gasperini L, Marques AP) -- Chapter 13. Wound healing induced hair follicle regeneration (Jiang Y, Myung P) -- Chapter 14. Hair follicles in wound healing and skin remodeling (Plotczyk M, Jimenez F) .
    Abstract: This book aims to comprehensively review the current cell-based strategies under investigation to achieve the regeneration of human hair follicles. The unique capacity of the human hair follicle to self-renew explains why this complex “mini-organ” has always attracted so much interest as a model for researchers to study stem cell biology and regenerative medicine. The hair follicle is considered a main reservoir of cutaneous stem cells, containing several pools of epithelial, melanocyte, and mesenchymal stem cells involved in hair follicle self-regeneration and pigmentation. In addition, while some of the different follicular cell types contribute to hair shaft growth, others participate in very important interfollicular functions such as dermal remodeling, re-epithelialization after wounding, and cutaneous stem cell homeostasis. The idea of human hair follicle regeneration either “de novo” or by activating dormant miniaturized follicles is not new, yet still continues to arouse enormous interest in the pursuit of a definitive cure for baldness. In contrast to hair follicle regeneration in mice, the attempts made with human follicles have been disappointing in terms of efficiency. However, recent advances in stem cell biology—as well as the appearance of new technologies like 3D printing—have revived expectations in this field of research. This book is divided into four sections. The first part includes an overview of the strategies used in hair follicle regeneration and a historical summary of the most important achievements to date. Parts two and three comprise the main body of the book, with detailed descriptions of the cells and tissue structures involved in hair follicle regeneration, followed by an elaboration of the different therapeutic strategies, engineering techniques, and a clinician’s perspective of stem cell-based therapies in hair loss treatments. Finally, the fourth part reviews the important contribution of the hair follicle in healing cutaneous wounds through the regeneration and remodeling of the dermis and epidermis after injury, as well as wound induced hair follicle neogenesis that occurs when the skin is injured.
    Type of Medium: Online Resource
    Pages: XII, 307 p. 73 illus., 70 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030983314
    Series Statement: Stem Cell Biology and Regenerative Medicine, 72
    URL: https://doi.org/10.1007/978-3-030-98331-4
    DOI: 10.1007/978-3-030-98331-4
    DDC: 610.72
    Language: English
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    Molecular Hydrogen for Medicine : The Art of Ancient Life Revived (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Human physiology. ; Medical sciences. ; Life sciences. ; Biomedical Research. ; Human Physiology. ; Health Sciences. ; Life Sciences.
    Description / Table of Contents: Part I What is Molecular Hydrogen Medicine? -- Chapter 1 The power of hydrogen molecules uncovered -- Chapter 2 Development of Molecular Hydrogen Medicine -- Chapter 3 From the front-line of research – Interviews -- Chapter 4 Physiological effects of the hydrogen molecule -- Chapter 5 Some fundamental properties of hydrogen and water -- Chapter 6 Functions of heavy water in living organisms -- Chapter 7 The future of Molecular Hydrogen Medicine -- Part II Tracing the History of Life and Hydrogen -- Chapter 8 The genesis of life in the world of hydrogen, Eons ago- Chapter 9 Drastic changes of living organisms in the oxygen age -- Chapter 10 Since the appearance of humans.
    Abstract: This book provides a comprehensive account of the current status of molecular hydrogen medicine, a young field that emerged with the discovery that inhalation of hydrogen gas leads to the elimination of harmful reactive oxygen species in rats. Various physiologic effects have since been demonstrated, and possible medical applications identified. Numerous clinical projects have now been undertaken, yielding startling results. Despite this, molecular hydrogen medicine remains underappreciated among the medical community at large. The author aims to rectify this situation by fairly but critically evaluating the potential clinical benefits based on the latest scientific research. In addition, the observed physiological effects of hydrogen gas are considered within the broad context of the evolution of life on earth, offering new perspectives and helping to place molecular hydrogen medicine legitimately within the framework of life sciences. Written in an accessible manner, the book will be of value to students, researchers, clinicians, and the general public.
    Type of Medium: Online Resource
    Pages: XI, 179 p. 89 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811571572
    URL: https://doi.org/10.1007/978-981-15-7157-2
    DOI: 10.1007/978-981-15-7157-2
    DDC: 610.72
    Language: English
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    Biomedical Translational Research : From Disease Diagnosis to Treatment (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Diagnosis. ; Molecular biology. ; Cancer. ; Biomedical Research. ; Clinical Genetics. ; Diagnosis. ; Molecular Biology. ; Cancer Biology.
    Description / Table of Contents: Chapter 1. Age-Rage Stress In The Pathophysiology Of Atherosclerosis And Its Treatment -- Chapter 2. Stem Cells In Dermatology: What The Future May Hold -- Chapter 3. Current Advances And Future Avenues In Endocrinology -- Chapter 4. Autologous Conditioned Serum In Lumbar And Cervical Radiculopathy: A Systematic Review -- Chapter 5. Bench To Bedside In Ophthalmology -- Chapter 6. Rapid Eye Movement In Sleep And Dream Sleep -- Chapter 7. Novel Cellular-Stress Models With Implications In Understanding And Treating Ent Pathologies -- Chapter 8. Respiratory Disorders : Contemporary Issues In 2020 -- Chapter 9. Discovery Of Hepatitis Viruses And Two Nobel Prizes : A Tale Of Observations Serendipity Collaboration Research Institute Inter Predated And Game Changing Innovation. Chapter 10. Conventional And Modern Approaches For Clinical And Laboratory Diagnosis Of Tuberculosis -- Chapter 11. Gut Microbes In Cardiovascular Diseases -- Chapter 12. Heart Failure – Future Perspectives -- Chapter 13. IL-10 : A Key Molecular In The Mitigation Of Heart Failure -- Chapter 14. Gene Therapy In Liver Disease : Challenges And Outcomes -- Chapter 15. Interrupting Crystal To Calculus Conversion : The Future Of Research In Urolithiasis -- Chapter 16. Stem Cells – Medical Marvel In Management Of Kidney Diseases -- Chapter 17. Deciphering The Code Of Male Infertility : Genetic Tests, Counselling And Molecular Basis Of Spermatogenic Failure -- Chapter 18. Translational Epidemiology In Cancer Research : The Less Travelled Path -- Chapter 19. Adenosine Pathway In Genitourinary Malignancies: A Promising Immunotherapeutic Target -- Chapter 20. Immune Checkpoint Inhibitors In Cancer Therapy: A Ray Of Hope -- Chapter 21. Recent Developments In The Immunotherapeutic Approaches For Cancer Treatment. Chapter 22. Thrombotic Complications In Women : Risks And Prevention -- Chapter 23. Biomedical Science And Women Health -- Chapter 24. Advances In The Role Of Macronutrients In Human Health And Diseases.
    Abstract: The second volume of the Biomedical translational research discusses advancements in biomedical research for understanding the pathophysiology of various diseases towards improving diagnosis and treatment. It presents the integration of molecular-based technologies, clinical genomics, and medical informatics to improve diagnostic and treatment strategies. Further, the book reviews molecular genomics approaches for diagnosis and managing tuberculosis. It also covers the innovative strategies for cancer treatment through targeting metabolic pathways, tumor microenvironment, cancer stem cells, and immune cells. It also illuminates novel strategies for heart failure diagnosis and therapeutic approaches for the treatment of heart failure. It discusses improvements in translational research for discovery of new diagnostic tests, identifying novel biomarkers and drugable targets, and predicting optimal treatments based on understanding the underlying molecular basis of the disease. Lastly, it reviews the preclinical models of restenosis and their application and limitation in the evaluation of device-based interventional technologies for the treatment of coronary artery diseases.
    Type of Medium: Online Resource
    Pages: XIV, 491 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811688454
    URL: https://doi.org/10.1007/978-981-16-8845-4
    DOI: 10.1007/978-981-16-8845-4
    DDC: 610.72
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    Advances in Hydrogen Sulfide Biology (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Physiology. ; Life sciences. ; Pharmacology. ; Biomedical Research. ; Physiology. ; Life Sciences. ; Pharmacology.
    Description / Table of Contents: Introduction -- Metabolism of endogenous H2S and its metabolites -- A common molecular switch for H2S to regulate multiple protein targets -- The protective role of H2S in the heart -- The proangiogenic effects of H2S -- H2S and the immune system -- Protection of H2S on the neurons -- The role of H2S in the metabolism of glucose and lipids -- Regulation of the ion channels by H2S -- The epigenetic mechanisms for H2S signalling -- The development of H2S donor.
    Abstract: Hydrogen sulfide (H2S) has emerged as an important gas signalling molecule in a series of organs/tissues, on the diseases of which it plays protective roles, such as proangiogenic effects in ischemic tissues, antiapoptotic effects in the cardiomyocytes, regularization of fatal arrhythmia in myocardial infarction, amelioration of inflammation in autoimmune diseases, modification of neuronal transmission, increase in sodium excretion from the kidney, and amelioration of insulin resistance, etc. This book focuses on the effect of hydrogen sulfide in cardiovascular system, immune system, nervous system, kidney, as well as on the metabolism of glucose and lipids and regulation of ion channels and so on. This book also provides the advances in the understanding of endogenous H2S metabolism and H2S protein targets, as well as H2S donors. It will benefit researchers in both academics and industry working on the underlying mechanism of H2S field and the future of translational medicine of H2S.
    Type of Medium: Online Resource
    Pages: IX, 236 p. 47 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811609916
    Series Statement: Advances in Experimental Medicine and Biology, 1315
    URL: https://doi.org/10.1007/978-981-16-0991-6
    DOI: 10.1007/978-981-16-0991-6
    DDC: 610.72
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    Computational Methods for Precision Oncology (2022)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Internal medicine. ; Bioinformatics. ; Biomedical Research. ; Internal Medicine. ; Bioinformatics.
    Description / Table of Contents: Part One: Basic Concepts in Precision Oncology -- Chapter 1. Design and Implementation of a precision oncology workflow -- Chapter 2. An overview of cancer genome sequencing -- Chapter 3. Software infrastructures for precision medicine workflows -- Part Two: Current Computational Methods and Tools in Precision Oncology -- Chapter 4. Somatic and germline variant calling from next-generation sequencing data -- Chapter 5. Identification of copy number alterations from next-generation sequencing data -- Chapter 6. Genome-wide discovery of large-scale structural variants from next-generation sequencing data -- Chapter 7. Assessment of microsatellite instability from next-generation sequencing data -- Chapter 8. Computational approaches for the investigation of intra-tumor heterogeneity and clonal evolution from bulk sequencing data -- Chapter 9. Analysis of the transcriptome for precision oncology applications -- Chapter 10. Computational methods for drug repurposing -- Chapter 11. Pathway for analysis for precision oncology applications -- Chapter 12. Identification of fusion transcripts from RNA-seq -- Chapter 13. Computational resources for the interpretation of variations in cancer -- Chapter 14. Analysis of electronic health records for precision oncology -- Chapter 15. Network approaches for precision oncology -- Chapter 16. Experimental validation of genomic alterations -- Part Three: Advanced Concepts - The Future of Precision Oncology -- Chapter 17. Molecular profiling of liquid biopsies for precision oncology -- Chapter 18. Artificial intelligence for precision oncology -- Chapter 19. Single-cell technologies in precision oncology -- Chapter 20. Computational approaches for precision immuno-oncology -- Chapter 21. Multi-pmics profiling of the tumor microenvironment -- Chapter 22. Epigenetic and precision oncology -- Chapter 23. Next generation knowledge bases to support precision oncology. .
    Abstract: Precision medicine holds great promise for the treatment of cancer and represents a unique opportunity for accelerated development and application of novel and repurposed therapeutic approaches. Current studies and clinical trials demonstrate the benefits of genomic profiling for patients whose cancer is driven by specific, targetable alterations. However, precision oncologists continue to be challenged by the widespread heterogeneity of cancer genomes and drug responses in designing personalized treatments. Chapters provide a comprehensive overview of the computational approaches, methods, and tools that enable precision oncology, as well as related biological concepts. Covered topics include genome sequencing, the architecture of a precision oncology workflow, and introduces cutting-edge research topics in the field of precision oncology. This book is intended for computational biologists, bioinformaticians, biostatisticians and computational pathologists working in precision oncology and related fields, including cancer genomics, systems biology, and immuno-oncology.
    Type of Medium: Online Resource
    Pages: XIV, 336 p. 36 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030918361
    Series Statement: Advances in Experimental Medicine and Biology, 1361
    URL: https://doi.org/10.1007/978-3-030-91836-1
    DOI: 10.1007/978-3-030-91836-1
    DDC: 610.72
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    Oxidative Stress : Human Diseases and Medicine (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Pharmacology. ; Biomedical Research. ; Cell Biology. ; Pharmacology.
    Description / Table of Contents: Oxidative stress and anti-oxidant strategies in human diseases -- Oxidative stress in the tumorimmune microenvironment -- Oxidative stress-mediated stem cell aging -- Stress proteins: Biological functions, human diseases and virus infections -- Importance of mitochondrial quality controls in Parkinson’s disease: the potential interplay of mitochondrial unfolded protein response and mitophagy -- Autophagy in cellular stress responses -- Cysteine metabolism in cancer progression and therapy resistance -- Stress and circadians -- ROS, glucose and lipid metabolism -- Drug repurposing: An avenue towards stress medicine in cancer therapy -- Redox regulation of metabolic enzymes in cancer -- Stress and inflammation -- Oxidative stress in cell signaling and cell fate determination under glucose starvation.
    Abstract: This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.
    Type of Medium: Online Resource
    Pages: VI, 323 p. 43 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811605222
    URL: https://doi.org/10.1007/978-981-16-0522-2
    DOI: 10.1007/978-981-16-0522-2
    DDC: 610.72
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    Ferroptosis: Mechanism and Diseases (2021)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Cytology. ; Lipids. ; Biomedical Research. ; Medical Genetics. ; Cell Biology. ; Cell Biology. ; Lipidology.
    Description / Table of Contents: Foreword -- Ferroptosis: Concepts and Definitions -- Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT inhibitors -- Iron Homeostasis and Metabolism: Two Sides of a Coin -- The Role of NCOA4-mediated Ferritinophagy in Ferroptosis -- Emerging Role for Ferroptosis in Infectious Diseases -- Small Molecule Regulators of Ferroptosis -- Necroptosis, The other main Caspase-Independent Cell Death.
    Abstract: This book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ferroptosis. It will enable readers to choose molecules for experimental design for in vitro and in vivo studies of ferroptosis. Furthermore, this volume highlights the aspects of iron metabolism and its connection to ferritinophagy, a ferritin selective autophagy, with profound implications in neurodegenerative diseases such as Alzheimer, Parkinson, Huntington and ALS. Lastly, it describes necroptosis, another important form of cell death, along with its connections to human disorders and potential crosstalk with ferroptosis. While covering basic concepts, the book delves into mechanisms and modulation of ferroptosis for treating a wide variety of human diseases thus offering a valuable and informative resource for both, scientists and clinical researchers.
    Type of Medium: Online Resource
    Pages: IX, 140 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030620264
    Series Statement: Advances in Experimental Medicine and Biology, 1301
    URL: https://doi.org/10.1007/978-3-030-62026-4
    DOI: 10.1007/978-3-030-62026-4
    DDC: 610.72
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    Cannabinoids and Sleep : Molecular, Functional and Clinical Aspects (2021)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Neurosciences. ; Biomedical Research. ; Neuroscience.
    Description / Table of Contents: Constituents of Cannabis Sativa -- Synthetic and Natural Derivatives of Cannabidiol -- Clinical Pharmacokinetics of Cannabinoids and Potential Drug-Drug Interactions -- Cannabinoid Receptors and Ligands: Lessions from CNS Disorders and the Quest for Novel Treatment Venues -- Sleep-Wake Neurobiology -- Cannabinoids and Sleep/Wake Control -- Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals -- Modulation of Noradrenergic and Serotonergic Systems by Cannabinoids: Electrophysiological, Neurochemical and Behavioral Evidence -- Natural Cannabinoids as Templates for Sleep Disturbances Treatment -- The Effect of Cannabinoids on the Brain´s Circadian Clock -- Effects of Cannabis Consumption on Sleep -- Addiction and Sleep Disorders -- Cannabis for Restless Legs Syndrome.
    Abstract: Research on cannabis and sleep is emerging with promising results. This book offers current and comprehensive knowledge on cannabinoid research results in connection with sleep. The volume covers aspects of the hemp plant Cannabis sativa, the pharmacology of cannabinoids, neurobiology and pharmacology of sleep and wakefulness, and the benefits and side effects of cannabis on the central nervous system. It further discusses the putative therapeutical properties of cannabinoids and endocannabinoids and their potential for the treatment of sleep disorders such as insomnia, obstructive sleep apnea, REM sleep behavior disorder, and restless legs syndrome. The book is written by medical and scientific experts in this field and intended for researchers from a range of disciplines such as biomedicine, biology, neurosciences, clinical medicine, neurology, and pharmacology.
    Type of Medium: Online Resource
    Pages: XXII, 183 p. 37 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030616632
    Series Statement: Advances in Experimental Medicine and Biology, 1297
    URL: https://doi.org/10.1007/978-3-030-61663-2
    DOI: 10.1007/978-3-030-61663-2
    DDC: 610.72
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    Integrated Science : Science Without Borders (2021)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Arts. ; Artificial intelligence. ; Knowledge, Theory of. ; Biomedical Research. ; Arts. ; Artificial Intelligence. ; Epistemology.
    Description / Table of Contents: Introduction on Integrated Science: Science without Borders -- The Human Person as an Integrated System -- On the Nature of Qualitative Research in Process Transformations: The Changing Man in the Changing World.-Integrated Science: Ambitions, Practicalities, Misunderstandings -- The Integration of the Sciences and Integral Human Knowledge -- The Indelible Stamp of Lowly Origins: An Epistemic Architecture between the Sciences and Humanities -- Transdisciplinary Science: Integration or Systematic, Strategic and Catalytic Knowledge -- Models and Integration -- Unlaws: the Missing “Dark Matter” in the Philosophy of Science -- Life - Stabilization of the Unstable through Controlling Influence of Quantum Information -- The Sustainable Humanist Concept in Art and Science Synergies -- From Being One to Being Many. Understanding the Diversity of Bio‐Life: Human, Nonhuman and Liminal Beings in the in Bio Art and Body Art -- Composite Bodies in Times of Catastrophe. On Socio‐Material Assemblies, Affective Contagions and the Biodegradable -- Life, Complexity, Communication: Integrating Social Systems Theory and Consciousness -- Rethinking the Reverse Side of Artificial Intelligence -- The Question of Transdisciplinarity between Modern Science and Critical Thought -- Adaptive Networks at the Crossroad of Artificial Intelligence and Formal, Biological, Medical and Social Sciences -- Are We Ready for "Them" Now? The Relationship between Human and Humanoid Robots -- Integrating Computer Simulation and Social Theory for Planning and Managing Complex Problems -- Rethinking Managerial Control in the Contemporary Context -- Innovation and Altruism: A New Paradigm Defining the Survival of Corporations -- Integrated Science 2050: Science without Borders.
    Abstract: The INTEGRATED SCIENCE Book series aims to publish the results of the most updated ideas and reviews in transdisciplinarity fields, to highlight the integration of different disciplines, including formal sciences, physical-chemical sciences, engineering, biological sciences, medical sciences, and social sciences. The whole world is suffering from complex problems; these are borderless problems; so, a borderless solution could be the solution for such complex problems. The “INTEGRATED SCIENCE: Science without Borders” is the first volume of the INTEGRATED SCIENCE Book series. It focuses on the human as an integrated system and finding solutions for the problems facing humanity. For its purpose, it introduces a kind of science, which is called integrated science and portrays results from every effort trying to integrate separate subjects. Integration of science with integral human knowledge, ancient science with modern science, and quantity with quality are a few examples of such efforts. Some difficulty might, however, lie in integrating knowledge systems. In this edited book, art and artificial intelligence reveal to us their different methods of work to overcome ambitions and become applicable to the world system full of unpredictable challenges. Art offers a lens to see the beauty of infinite complexity. The resultant artistic background would permit the perfect programming and bioengineering of biological systems, which we could never do by direct eye viewing. Networking is the spot where the crossing of formal, biological, medical, and social sciences with artificial intelligence takes place. By working within a network, individual thinking to the old unresolved problems reduces to simulation and bioengineering, a relatively effortless route for innovation, creativity, and altruism. In this manner, it would be understandable that there is an obvious way to speed up the growth of science – that is, moving on the edge of the intersection between knowledge-based systems. The INTEGRATED SCIENCE Book series is to provide an overview of the essential elements of integrated science. The unique aspect of this series, privileging it from other books, is covering all aspects of science as a true one nature.
    Type of Medium: Online Resource
    Pages: XVIII, 495 p. 112 illus., 97 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030652739
    Series Statement: Integrated Science, 1
    URL: https://doi.org/10.1007/978-3-030-65273-9
    DOI: 10.1007/978-3-030-65273-9
    DDC: 610.72
    Language: English
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    Inflammation and Metastasis (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Human physiology. ; Immunology. ; Cytology. ; Biomedical Research. ; Human Physiology. ; Immunology. ; Cell Biology.
    Description / Table of Contents: Chapter 1 General Thinking About Inflammation -- Chapter 2 Inflammation from the Standpoint of Leukocytes -- Chapter 3 Vessels and Coagulation -- Chapter 4 Sterile Inflammation -- Chapter 5 Issue of Self and Non-self -- Chapter 6 Extension of Endogenous Field -- Chapter 7 Evidence for Existence of Endogenous TLR4 Ligands -- Chapter 8 Autoinflammatory Disorders -- Chapter 9 Cancer in General -- Chapter 10 Basic Research -- Chapter 11 Tumor Microenvironment -- Chapter 12 Whole-Body Matter -- Chapter 13 Premetastatic Microenvironment -- Chapter 14 What Is Homeostasis? -- Chapter 15 Explanation of Metastasis by Homeostatic Inflammation -- Chapter 16 Therapeutic Potential.
    Abstract: This book, now in a thoroughly revised and updated second edition, provides the latest information on cancer metastasis from the perspective of inflammation and presents new ideas on the complicated mechanisms of metastasis and potential therapeutic targets. Key features include discussion of mechanisms recently identified to be involved in the resolution phase of inflammation, presentation of the latest evidence regarding the roles of endogenous TLR4 ligands in metastasis, and thorough explanation of the concept of homeostatic inflammation and current understanding of the significance of its dysregulation for metastasis. Structure-based thinking is another important element of the book, and it is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, at the center of which cancer is located. Examples of the many additional specific topics covered in this edition include the functional involvement of new types of RNA in cancer, the insights offered by recent advances in bioinformatics, and the potential of a casein kinase 1α inhibitor in the treatment of acute myeloid leukemia. The book will be a valuable update and resource for both experienced and younger researchers. Homeostasis, originated from an idea of internal milieu by Claude Bernard, is eventually maintained by endogenous elements. The essential features of inflammation are leukocyte mobilization and increased vascular permeability, which could take place in many homeostatic or physiological conditions at low levels. Homeostatic inflammation is a concept to explain pathological settings such as metastasis in which irrespective of its level those inflammatory features are misused with endogenous molecules (see Chap. 14,15). As inflammation comprises many biological fields, targeting a single molecule for a disease could potentially make a therapeutic contribution to other diseases. For example, one focus is applied here to the roles of calprotectin in lung metastasis, which is implicated in psychiatric disorders and COVID-19 as shown by recent evidence.
    Type of Medium: Online Resource
    Pages: XX, 518 p. 81 illus., 33 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9789811617577
    URL: https://doi.org/10.1007/978-981-16-1757-7
    DOI: 10.1007/978-981-16-1757-7
    DDC: 610.72
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    Career Advice for Young Scientists in Biomedical Research : How to Think Like a Principal Investigator (2021)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Vocational guidance. ; School management and organization. ; School administration. ; Career education. ; Biomedical Research. ; Career Counseling. ; Organization and Leadership. ; Career Skills.
    Description / Table of Contents: Chapter 1: “Carving Your Own Path” – shaping your scientific identity -- Chapter 2: The Two Cornerstones of Academic Research: Writing Grant Applications and Publications -- Chapter 3: Setting up a Successful Research Group -- Chapter 4: Leading Your Research Group as a Principal Investigator -- Chapter 5: The Daily Work of Principal Investigators -- Chapter 6: Dealing with Failure and Stress in Academic Research -- Chapter 7: Thoughts of Principal Investigators about Work, Science, and Themselves -- Chapter 8: Under the Hood – Common Thinking Patterns of Principal Investigators -- Chapter 9: Epilogue -- Chapter 10: Methods.
    Abstract: Pursuing a career in biomedical research can be daunting, considering the stiffer competition and uncertain career prospects in academia. This book summarizes career advice gathered during in-depth interviews with 106 biomedical scientists who lead their own laboratories. The participating principal investigators are from 44 research institutions in 11 countries. This book is unique in that it provides a glimpse into the mindset of principal investigators. Here, the reader will learn about common thought patterns and values, as well as the range of opinions and ways of thinking to be found among a large group of active principal investigators – without having to read more than a hundred individual autobiographies. The book will benefit all PhD students who want to learn more about their supervisor’s mindset in order to successfully complete their projects. It can help freshly graduated PhDs planning to pursue an academic career, and MDs contemplating a career in research, to decide whether they truly want to embark on this path. Lastly, it can offer young principal investigators a source of inspiration on how to succeed and achieve their goals.
    Type of Medium: Online Resource
    Pages: XIX, 209 p. 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030855710
    URL: https://doi.org/10.1007/978-3-030-85571-0
    DOI: 10.1007/978-3-030-85571-0
    DDC: 610.72
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    The Immunogenetics of Dermatologic Diseases (2022)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Immunology. ; Dermatology. ; Biomedical Research. ; Medical Genetics. ; Immunology. ; Biomedical Research. ; Dermatology.
    Description / Table of Contents: Genetics control of immune responses -- Non-melanoma skin cancer -- Melanoma -- Psoriasis -- Atopic dermatitis -- Contact dermatitis -- Lichen planus -- Pemphigus and pemphigoids -- Morphea and Lichen Sclerosus -- Granuloma annulare and Necrobiosis lipoidica -- Alopecia areata -- Vitiligo -- Acne Vulgaris and Rosacea -- Urticaria and Angioedema -- Cutaneous drug reaction -- Photodermatologic disorders -- Infantile Haemangioma and other vascular malformations.
    Abstract: This book intends to investigate the broad spectrum of genetic changes in immunological processes involved in cutaneous diseases. One of the main goals of immunogenetic studies is finding susceptibility genes for complex diseases. This can provide an insight into the pathogenesis of the condition in a way that is not easily achievable through other kinds of studies. Thus they are a rational initial step for generating hypotheses about disease pathogenesis. This may especially benefit dermatology, a field notorious for having too many diseases with unknown etiologies. Immunogenetic investigations have made targeted treatment strategies possible for diseases such as psoriasis and pemphigus. Even though these strategies have revolutionized the management of chronic dermatological conditions such as psoriasis, still there are a lot of unanswered questions. For instance, psoriasis patients respond very differently to each of the commercially available biological agents. This diversity could be partially explained by the differences in the sets of genes responsible for disease induction in each individual. Thus whole genome sequencing strategies, if feasible at individual levels, might help in tailoring these targeted treatments based on specific genetic backgrounds. Our intention in preparing this book was to explore the broad spectrum of the genetic aspects of immunological processes involved in cutaneous diseases. We have tried to cover most areas of dermatology where enough studies were available to gather a chapter. Still, there is a substantial lack of knowledge on the immunogenetics of many dermatological conditions. We hope that this book would encourage the investigators to fill these gaps of knowledge.
    Type of Medium: Online Resource
    Pages: XXI, 450 p. 64 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030926168
    Series Statement: Advances in Experimental Medicine and Biology, 1367
    URL: https://doi.org/10.1007/978-3-030-92616-8
    DOI: 10.1007/978-3-030-92616-8
    DDC: 610.72
    Language: English
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    Tumor Suppressor Par-4 : Role in Cancer and Other Diseases (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Internal medicine. ; Biomedical Research. ; Internal Medicine.
    Description / Table of Contents: Introduction. --Part 1 -- Chapter 1. Role of Par-4 in lung cancer -- Chapter 2. Prostate apoptosis response-4 in nasopharyngeal carcinoma -- Chapter 3. Role of Par-4 in Chemoresistance and targeted therapies in ovarian and endometrial cancers -- Chapter 4. Regulation of Par-4 and role in GI tumors -- Chapter 5. Role of Par-4 in prostate cancer -- Chapter 6. Activation of apoptosis by Par-4 in pancreatic cancer -- Chapter 7. Role of Par-4 and GRP78 in Glioblastoma -- Chapter 8. Role of Par-4 in breast cancer recurrence -- Chapter 9. Involvement of Par-4 in breast cancer -- Chapter 10. Role of endogenous Par-4 in CLL -- Chapter 11. Role of Par-4 in inhibition of TCL1 induced growth -- Chapter 12. Par-4/THAP in survival of T-cell acute lympoblastic leukemia cells -- Chapter 13. Par-4 expression in cholangiocarcinoma -- Chapter 14. Par-4 suppresses breast cancer growth and invasion of breast cancer cells -- Chapter 15. PAWR as direct SRC-1/HOXC11 suppression target -- Chapter 16. Par-4 cleavage is required for TNF induced apoptosis -- Chapter 17. Par-4 secretagogues -- Chapter 18. Recombinant production and characterization of SAC -- Chapter 19. Anti-tumor effects of plant derived Par-4 -- Chapter 20. Par-4 in Mycobacterium tuberculosis Infected Macrophages -- Part 2 - Role in other Diseases -- Chapter 21. Role of Par-4 in ceramide inducible effects in neurons -- Chapter 22. Role of Par-4 in Alzheimers disease -- Chapter 23. Dopamine signaling in association with induction of Par-4 protein expression -- Chapter 24. Par-4 (PAWR) in major depressive disorder -- Chapter 25. Par-4 dependent apoptosis of islet β cells in type 2 diabetes -- Chapter 26. Par-4 in cardiac fibroblast senescence -- Chapter 27. Par-4 in ocular development and disease -- Chapter 28. Par-4 in apoptosis during human salivary gland development -- Chapter 29. Suppression of Par-4 protects human renal proximal tubule cells from apoptosis -- Chapter 30. Lessons from knockout mice -- Part 3 - From Bench to Bedside -- Chapter 31. Par-4 secretagogues in clinical trials -- Chapter 32. Potential of Par-4 as a therapeutic target for cancer.
    Abstract: Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.
    Type of Medium: Online Resource
    Pages: X, 331 p. 121 illus., 93 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030805586
    URL: https://doi.org/10.1007/978-3-030-80558-6
    DOI: 10.1007/978-3-030-80558-6
    DDC: 610.72
    Language: English
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    Bone Tumors in Domestic Animals : Comparative Clinical Pathology (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Veterinary medicine. ; Agricultural genome mapping. ; Biomedical Research. ; Veterinary Science. ; Agricultural Genetics.
    Description / Table of Contents: Chapter 1: Outline Of Anatomy/Physiology Of Skeletal Tissues -- Chapter 2: Tumors Of The Musculoskeletal System -- Chapter 3: Tumor-Like Lesions Of The Musculoskeletal System -- Chapter 4: General Considerations About Bone Tumors -- Chapter 5: Appendix: Manual For Histological Preparation And Examination Of Tissues Containing Bone And Cartilage.
    Abstract: This book comparatively examines the etiopathogenetic, clinical-pathological, diagnostic and therapeutic strategies of the main bone tumors of domestic animals. The book also includes a description of the most significant aspects of macroscopic, microscopic, immunohistochemical, instrumental, diagnostic imaging and molecular biology aspects of spontaneous bone tumors in Veterinary Medicine, with also interspecies comparative aspects, including the human one. Last but not least, the book provides an overview of the new diagnostic and therapeutic frontiers related to the approach to animal bone tumors. The book serves as essential reading for professionals, researchers and students who work or want to tackle three paths in the field of comparative veterinary bone oncology.
    Type of Medium: Online Resource
    Pages: XV, 193 p. 90 illus., 84 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030902100
    URL: https://doi.org/10.1007/978-3-030-90210-0
    DOI: 10.1007/978-3-030-90210-0
    DDC: 610.72
    Language: English
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  • 76
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    Transportome Malfunction in the Cancer Spectrum : Ion Transport in Tumor Biology (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Internal medicine. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Internal Medicine. ; Physiology.
    Description / Table of Contents: Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression -- Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening -- Ion channels in Lung Cancer -- Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer -- Transportome Malfunctions and the Hallmarks of Pancreatic Cancer -- How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer -- Ion Channels in Glioma Malignancy -- Membrane Transporters and Channels in Melanoma -- Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application.
    Abstract: Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression Halima Ouadid-Ahidouch, Hamid Morjani, Julie Schnipper, Alban Girault, and Ahmed Ahidouch Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening Valerio Farfariello, Natalia Prevarskaya, and Dimitra Gkika Ion Channels in Lung Cancer Etmar Bulk, Luca Matteo Todesca, and Albrecht Schwab Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer Giuliano Ciarimboli, Gerit Theil, Joanna Bialek, and Bayram Edemir Transportome Malfunctions and the Hallmarks of Pancreatic Cancer Qi Ling and Holger Kalthoff How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer Christian Stock Ion Channels in Glioma Malignancy Luigi Catacuzzeno, Luigi Sforna, Vincenzo Esposito, Cristina Limatola, and Fabio Franciolini Membrane Transporters and Channels in Melanoma Ines Böhme, Roland Schönherr, Jürgen Eberle, and Anja Katrin Bosserhoff Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application Nagore Del-Río-Ibisate, Rocío Granda-Díaz, Juan P. Rodrigo, Sofía T. Menéndez, and Juana M. García-Pedrero.
    Type of Medium: Online Resource
    Pages: IX, 427 p. 50 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030909208
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 181
    URL: https://doi.org/10.1007/978-3-030-90920-8
    DOI: 10.1007/978-3-030-90920-8
    DDC: 610.72
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    Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical microbiology. ; Internal medicine. ; Biomedical Research. ; Medical Microbiology. ; Internal Medicine.
    Description / Table of Contents: 1. Inflammatory components of the thyroid cancer microenvironment - an avenue for identification of novel biomarkers -- 2. Disruption of Cell-Cell Communication in Anaplastic Thyroid Cancer as an Immunotherapeutic Opportunity -- 3. Exosomes in the Healthy and Malignant Bone Marrow Microenvironment -- 4. Structural Biology of the Tumor Microenvironment -- 5. Metabolic interactions between tumor and stromal cells in the Tumor Microenvironment -- 6. Interacting Genetic Lesions of Melanoma in the Tumor Microenvironment: Defining a Viable Therapy -- 7. Non-coding RNAs in Papillary Thyroid Cancer: Interaction with cancer associated fibroblasts (CAFs) in the Tumor Microenvironment (TME) and regulators of differentiation and Lymph Node Metastasis.
    Abstract: Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor microenvironment's various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.
    Type of Medium: Online Resource
    Pages: XIII, 164 p. 19 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030832827
    Series Statement: Advances in Experimental Medicine and Biology, 1350
    URL: https://doi.org/10.1007/978-3-030-83282-7
    DOI: 10.1007/978-3-030-83282-7
    DDC: 610.72
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    BioSensing, Theranostics, and Medical Devices : From Laboratory to Point-of-Care Testing (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Nanobiotechnology. ; Biotechnology. ; Nanomedicine. ; Biomedical Research. ; Nanobiotechnology. ; Biotechnology. ; Nanomedicine and Nanotoxicology.
    Description / Table of Contents: Chapter 1_Biosensing: Material, methods and principle of detection -- Chapter 2_Biosensing applications in the development of medical devices -- Chapter 3_Theranostics: basic principles -- Chapter 4_Material and technique advancements in the development of theranostic products -- Chapter 5_Medical device development strategies -- Chapter 6_Research aspects for the development of medical devices -- Chapter 7_Biosensor-based commercialized point-of-care devices -- Chapter 8_Medical devices in clinical set up -- Chapter 9_Clinical validation of medical devices -- Chapter 10_Regulatory steps involved in the validation of medical devices -- Chapter 11_Protocol for registration process of point-of-care device at FDA or equivalent agencies -- Chapter 12_Opportunities and challenges in medical device development -- Chapter 13_Prospective journey of the research idea from laboratory to the user in the clinic. .
    Abstract: This book provides up-to-date information on the prototypes used to develop medical devices and explains the principles of biosensing and theranostics. It also discusses the development of biosensor and application-orientated design of medical devices. In addition to summarizing the clinical validation of the developed techniques and devices and the regulatory steps involved in their commercialization, the book highlights the latest research and translational technologies toward the development of point-of-care devices in the health care. Lastly, it explores the current opportunities, challenges and provides troubleshooting on the use of biosensors in precision medicine. The book is helpful for researchers and medical professionals working in the field of clinical theranostics, and medical-device development wanting to gain a better understanding into the principles and processes involved in the development of biosensors.
    Type of Medium: Online Resource
    Pages: IX, 376 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811627828
    URL: https://doi.org/10.1007/978-981-16-2782-8
    DOI: 10.1007/978-981-16-2782-8
    DDC: 610.72
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    Invasive Diagnostics and Therapy (2022)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Tumors Classification. ; Surgery. ; Cytokines. ; Virology. ; Biomedical Research. ; Cancer Staging. ; Surgery. ; Cytokines and Growth Factors. ; Virology.
    Description / Table of Contents: Compliance with the Surgery Safety Checklist: An Update on the Status -- Surgical Safety Checklist: Polychromatic or Achromatic Design -- Surgical Strategy and Clinical Outcome in Patients with Bronchial Carcinoids -- Frozen Section or Intraoperative Cytology: Are We Ready for a Paradigm Shift in Thoracic Surgery? -- Clinical Outcome in Patients with Nosocomial COVID-19 Infection After Thoracic Surgery -- Cytological Diagnostic Procedures in Malignant Mesothelioma -- Combination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusions -- Cytokines in Renal Cell Carcinoma: A Step Towards Earlier Detection and Targeted Therapy -- Primary Hyperparathyroidism Secondary to Ectopic Parathyroid Adenoma: A Case Report -- Perception of Well-Being and Quality of Life in Obese Patients After Bariatric Surgery -- Do Multiple Brain Lesions Always Connote Worse Outcomes? Appraisal Evidence from a Tertiary Care Center in Koshi/Purbanchal Province of Nepal -- Radioimaging and Demographic Profiles of Patients with Spontaneous Intracerebral Hemorrhage: A Need for the Pragmatic Referral System -- Anticytokine Treatment of Rheumatoid Arthritis: An Observational Report.
    Abstract: The book is an update on contentious or unsettled issues concerning invasive diagnostic and therapeutic challenges in cancer and related disorders, focusing on the surgical approach. Topics include recommendations for the best practice in using the surgery safety checklist, surgical strategies in a variety of thoracic cancers, renal cell carcinoma, tumors of parathyroid glands, mesothelioma, and bariatric surgeries. The focus is on the diagnostic and therapeutic challenges of aggressive cancerous entities, choosing the most beneficial modes for optimal outcomes and patient survival. Chapters also address radioimaging and therapy outcomes in different intracranial lesions leading to severe neurological disabilities. The areas of medical practice addressed are still veiled in uncertainty, yet-unresolved pathogenetic background, and have a substantial component of empirical rather than evidence-based clinical approach. Pursuing and sharing new ideas and innovations is essential for improving the management and outcome. The book endeavors to disseminate and deliberate on the latest medical knowledge, studies, and advancements in surgical and diagnostic dealing with cancer. The book is addressed to physicians and surgeons, and all allied health care professionals engaged in patient care and therapy.
    Type of Medium: Online Resource
    Pages: VI, 119 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030988579
    Series Statement: Clinical and Experimental Biomedicine, 1374
    URL: https://doi.org/10.1007/978-3-030-98857-9
    DOI: 10.1007/978-3-030-98857-9
    DDC: 610.72
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    Translational Informatics : Sports and Exercise Medicine (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Bioinformatics. ; Sports sciences. ; Medical informatics. ; Biomedical Research. ; Bioinformatics. ; Sport Science. ; Health Informatics.
    Description / Table of Contents: Chapter 1. Ontologies and Knowledge Graphs for Exercise Medicine -- Chapter 2. Participatory exercise medicine and personalized healthcare -- Chapter 3. Integration of genetic and phenotyping data for sports medicine -- Chapter 4. Microbiota, sports and exercise medicine -- Chapter 5. Human immune system and exercise medicine: current process and future directions -- Chapter 6. Circadian Rhythm and Personalized Exercise -- Chapter 7. Data-driven Exercise Medicine for Cardiovascular Disease -- Chapter 8. Physical Activities and Prevention of Neurodegenerative Diseases -- Chapter 9. Exercise guidelines for cancer patients -- Chapter 10. Diabetes as a metabolic disease and translational exercise medicine informatics.
    Abstract: The book provides readers the informatics and data-driven models for the discovery of personalized excise prescriptions applied to different cases. Overdiagnosis or over-treatment often happened since the complex interaction among the lifestyle, genetic, and environmental factors. Sports and exercise are reported efficient to prevent or reduce the risk of diseases, but the interactions between sports/exercise and disease are personalized and complex. Translational informatics is a powerful paradigm and it promotes the transfer of big data, knowledge and models to the precision application of sports to prevent diseases. Sports and exercise may have different effects on diverse diseases including cancers, neurodegenerative disease, and cardiovascular diseases, etc. This book covers many modern informatics models such as ontologies, knowledge graphs, blockchain, participatory medicine, semantic artificial intelligence, big data modeling, and so on. It also describes the challenges for the sports and exercise medical data sharing and standardization, the privacy protection of data as well as the integration of data from genomic level to physiological phenotype level. This book will be helpful to the readers who are interesting in sports and exercise medicine, healthcare, big data modeling, artificial intelligence in medicine and healthcare. .
    Type of Medium: Online Resource
    Pages: IX, 234 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811691621
    URL: https://doi.org/10.1007/978-981-16-9162-1
    DOI: 10.1007/978-981-16-9162-1
    DDC: 610.72
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    Biomarkers of Radiation in the Environment : Robust Tools for Risk Assessment (2022)
    Dordrecht :Springer Netherlands :
    Details
    Keywords: Biochemical markers. ; Radiation dosimetry. ; Environmental chemistry. ; Biochemistry. ; Biomarkers. ; Radiation Dosimetry and Protection . ; Environmental Chemistry. ; Biological Chemistry.
    Description / Table of Contents: TECHNIQUES FOR BIOMARKER DEVELOPMENT -- Chapter 1. Reducing Uncertainties In Live Monitoring Of Radiation In Wildlife -- Chapter 2. Synchrotron Light Facilities And Applications In Life Sciences -- Chapter 3. Elemental Imaging In Biology Using Synchrotron X-Ray Fluorescence Microscopy -- LOW-DOSE EFFECT MECHANISMS Chapter 4. Modelling Direct And Indirect Effects Of Radiation: Experimental, Clinical And Environmental Implications -- Chapter 5. Immune Networks In The Context Of Low Dose Ionizing Radiation -- Chapter 6. Learning From Nato Biomarker Research For Humans -- BIOMARKERS FOR RISK EVALUATION -- Chapter 7. Exosomes As Radiation Biomarkers -- Chapter 8. Monitoring Very Low Dose Radiation Damage In Dna Using “Field-Friendly” Biomarkers -- Chapter 9. The Development Of Bio-Assays Based On Non-Targeted Effects Of Radiation; A Potential Worm-Hole Into Ecosystem Level Biomarkers -- BIOMARKERS IN WILDLIFE Chapter 10. Birds As Bioindicators Of Radioactive Contamination And Its Effects -- Chapter 11. Amphibians In Field Radioecology: A Review And Perspective -- Chapter 12. Measuring Adaptive Responses Following Chronic And Low Dose Exposure In Amphibians -- Chapter 13. Are There Ecosystem-Relevant Endpoints For Measuring Radiation Impacts?.-Chapter 14. Biomarkers And Ecological Indicators For Environmental Radioactivity In Invertebrates.-BIOMARKER USE AND RESPONSES -- Environment, Workers And Public -- Chapter 16. Application Of The International System Of Radiation Protection In Fit-For-Purpose Assessment Of Impacts -- Chapter 17. Practicalities Of Mainstreaming Biomarker Use – A Canadian Perspective -- Index.
    Abstract: This proceedings volume results from the NATO Advanced Research Workshop on 'Biomarkers of Radiation in the Environment: Robust Tools for Risk Assessment (BRITE)’. The BRITE workshop discussed insights from cancer research, epigenetics, non-human and human risk assessment, since many of the state-of-the-art biomarkers being developed for humans deserve consideration for environmental applications and vice versa. Sessions were very wide-ranging covering methods, mechanisms, cross disciplinary application and regulation. The chapters in this book have been grouped into five major themes that were covered by the BRITE workshop: · Techniques for biomarker development · Low-dose effect mechanisms · Biomarkers for risk evaluation · Biomarkers in wildlife · Biomarker use and responses Each chapter has been written independently and reflects the views of the chapter author(s). Therefore, the readers can form their own balanced view of the different perspectives on biomarkers of radiation in the environment. Given the breadth of topics covered and the state-of-the-art perspectives shared by leading experts in their respective fields, this book should form a valuable resource for anyone with an interest in how biomarkers can be used to improve our understanding of radiation in the environment and its potential impacts.
    Type of Medium: Online Resource
    Pages: XVI, 330 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789402421019
    Series Statement: NATO Science for Peace and Security Series A: Chemistry and Biology,
    URL: https://doi.org/10.1007/978-94-024-2101-9
    DOI: 10.1007/978-94-024-2101-9
    DDC: 610.72
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    Hot and Cold Theory: The Path Towards Personalized Medicine (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Human physiology. ; Pharmacology. ; Nutrition   . ; Biomedical Research. ; Human Physiology. ; Pharmacology. ; Nutrition.
    Description / Table of Contents: 1 Introduction: Hot and Cold Theory, the Path Towards Personalized Medicine -- Part I Definitions and Beliefs -- 2 Principle of Hot and Cold and Its Clinical Application in Traditional Chinese Medicine -- 3 Principle of Hot and Cold and Its Clinical Application in Persian Medicine -- 4 Principle of Hot (Ushna) and Cold (Sheeta) and Its Clinical Application in Ayurvedic Medicine -- 5 Principle of Hot and Cold and Its Clinical Application in Latin American and Caribbean Medicines -- Part II Scientific Evidence -- 6 Hot and Cold Theory: Evidence in Nutrition -- 7 Hot and Cold Theory: Evidence in Pharmacology -- 8 Hot and Cold Theory: Evidence in Physiology -- 9 Hot and Cold Theory: Evidence in Systems Biology -- Part III Perspective -- 10 Hot and Cold Theory: A Personalized Medicine Approach -- 11 Hot and Cold Theory: Future Perspective.
    Abstract: This book is about the theory of Hot and Cold, a mutual fundamental base of traditional medicines all around the world. The theory describes the dynamic balance state of the body on the axis of hot and cold for each individual and proposes the fact that deviation from this equilibrium is a predisposing factor for diseases. Such an approach helps practitioners to provide treatments tailored to the patient’s condition, not the disease. This book, for the first time, has gathered native descriptions of Hot and Cold theory in different traditional medicines, including traditional Chinese medicine, Persian (Humoral, Unani) medicine, Ayurvedic medicine and Latin American and Caribbean medicines. After defining the common ground, contemporary research - in nutrition, pharmacology, physiology and systems biology - has been explored using scientific methodology. This work is the result of an international collaboration of more than 30 scientists and scholars with high reputations in their fields. Hot and Cold theory, as a holistic individualized approach in prevention, diagnosis and treatment, can be merged into the novel fast-paced concepts in systems biology and precision medicine. Through this bridge, the authors propose that the Hot and Cold theory should be revisited more deeply by medical scientists, who are the main audience of this book, to pave the way towards integrated holistic personalized medicine.
    Type of Medium: Online Resource
    Pages: XXIII, 174 p. 16 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030809836
    Series Statement: Advances in Experimental Medicine and Biology, 1343
    URL: https://doi.org/10.1007/978-3-030-80983-6
    DOI: 10.1007/978-3-030-80983-6
    DDC: 610.72
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    From Malignant Transformation to Metastasis : Ion Transport in Tumor Biology (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Physiology.
    Description / Table of Contents: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression -- Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression -- Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer -- Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues -- Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism?.
    Abstract: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression Line O. Elingaard-Larsen, Michala G. Rolver, Ester E. Sørensen, and Stine F. Pedersen Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression Ebbe Boedtkjer Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer Larry Fliegel Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues Giorgia Scarpellino, Luca Munaron, Anna Rita Cantelmo, and Alessandra Fiorio Pla Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism? Christian Stock.
    Type of Medium: Online Resource
    Pages: XV, 175 p. 40 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030998004
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 182
    URL: https://doi.org/10.1007/978-3-030-99800-4
    DOI: 10.1007/978-3-030-99800-4
    DDC: 610.72
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    Cell Culture Engineering and Technology : In appreciation to Professor Mohamed Al-Rubeai (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Biology Technique. ; Regenerative medicine. ; Biomedical engineering. ; Biomedical Research. ; Cell Biology. ; Biological Techniques. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Biopharmaceuticals Produced from Cultivated Mammalian Cells -- Remote Control of Mammalian Therapeutic Designer Cells -- Next generation cell engineering using microRNAs -- An Omic’s data-driven approach towards engineering mammalian cell factories and bioprocesses for biopharmaceutical production -- Redesigning spent media from cell culture bioprocess to feed new bacterial fermentations -- Monoclonal antibody glycoengineering for biopharmaceutical quality assurance -- Next-generation cell engineering platform for improving recombinant protein production in mammalian cells -- Manufacturing human pluripotent stem cells and differentiated progenitors -- Biomanufacturing of Mesenchymal Stromal Cell for Therapeutic Applications -- Process Design for hMSC Products in Stirred Tank Bioreactors -- Bio-production of Adeno-associated virus for gene therapy -- Scale-up (and scale-down) of CHO cell culture, with a focus on how to adjust the various culture parameters/setpoints across different systems from lab-scale to manufacturing-scale -- Intensified and Continuous mAb Production with Single-Use Systems -- Mathematical modelling of cell culture processes -- Model-assisted design concepts for mammalian cell culture processes -- Bioprocess monitoring and control -- Industrial Monitoring of Cell Culture.
    Abstract: This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.
    Type of Medium: Online Resource
    Pages: X, 550 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030798710
    Series Statement: Cell Engineering, 10
    URL: https://doi.org/10.1007/978-3-030-79871-0
    DOI: 10.1007/978-3-030-79871-0
    DDC: 610.72
    Language: English
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    A Roadmap to Successful Scientific Publishing : The Dos, the Don’ts and the Must-Knows (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical sciences. ; Vocational guidance. ; Career education. ; Biomedical Research. ; Health Sciences. ; Career Counseling. ; Career Skills.
    Description / Table of Contents: Part 1: Getting started -- Chapter 1: The why and the what of scientific research and publishing -- Chapter 2: Understanding research ethics -- Chapter 3: How to structure a scientific article, conference poster and presentation -- Part 2: The Hidden Bumps -- Chapter 4: Who gets authorship status? -- Chapter 5: The art of journal selection -- Chapter 6: Understanding the editor’s perspectives -- Part 3: The Destination -- Chapter 7: Converting a scientific article for the media -- Chapter 8: What are research metrics and why should I care? -- Chapter 9: Beyond your scientific publication -- Chapter 10: The Editor’s Perspective – Full-Length Interviews.
    Abstract: In the age of "publish or perish," this book provides everything one needs to know about conducting research and successfully publishing it in a scientific journal. The reader learns about the complete process of scientific publishing: from selecting the most appropriate research design, to obtaining permissions and funding, to resourcefully presenting the research results in a poster and oral presentation. Additionally, the practical tips provided here help the reader formulate a compelling scientific article and choose the most suitable journal (subscription vs. the various open access modalities) for their publication. This book also addresses "invisible aspects" of scholarly publishing that are nonetheless important and that everyone should know and understand: avoiding predatory journals, understanding the editor's perspective, and becoming familiar with the various research metrics (from author to journal) that can all determine success or failure of a publication. Written in an informal style in which the author shares personal perspectives and experiences, the book is easily accessible to the reader. The book offers early career scientists in biomedicine and medicine a unique perspective on publishing research articles and how this process can enhance the authors' "scientific value" within the scientific ecosystem as well as their personal CVs.
    Type of Medium: Online Resource
    Pages: XIV, 119 p. 25 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030992958
    URL: https://doi.org/10.1007/978-3-030-99295-8
    DOI: 10.1007/978-3-030-99295-8
    DDC: 610.72
    Language: English
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    Integrative Clinical Research (2022)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Pain medicine. ; Artificial intelligence. ; Biomedical Research. ; Pain Medicine. ; Artificial Intelligence.
    Description / Table of Contents: Artificial Intelligence and Precision Medicine: A Perspective -- Pedobarography in Physiotherapy: A Narrative Review on Current Knowledge -- Quantum Medicine: A Role of Extremely Low-Frequency Magnetic Fields in the Management of Chronic Pain -- Manual Therapy Approach to the Extraocular Muscles in Migraine Treatment: A Preliminary Study -- Capacitive and Resistive Electric Transfer Therapy: A Comparison of Operating Methods in Non-specific Chronic Low Back Pain -- Serum Impedance in Children with Recurrent Respiratory Infections -- Olfactory Response to Altitude Hypoxia: A Pilot Study During a Himalayan Trek -- The Impact of Change in Hospital Admissions When Primary Care Is Provided by a Single Primary Care Physician: A Cohort Study Among HMO Patients in Israel -- Risk of Falls in Patients Aged Over 65 in the Context of the Treatment Facility -- Anthropometric Indices as Long-Term Predictors of Diabetes in Impaired Fasting Glucose Metabolism: Findings in the PURE Study in Poland -- Cardiovascular Risk Factors Drive Impaired Fasting Glucose to Type 2 Diabetes: Findings After a 9-Year Follow-Up in the PURE Study in Poland -- Sleep-Disordered Breathing in Pregnancy.
    Abstract: This book embraces a comprehensive range of research across several disciplines, providing insights and fresh perspectives on clinical topics, emphasizing the integrative medical approach. The book also addresses an increasing role of artificial intelligence in the development of clinical methodologies, research, and patient-oriented care. The authors share expertise and experience in rehabilitation medicine whose healing-effects particularly depend on the interaction between the therapist and patient. Chapters present novel approaches in manual rehabilitative therapy of common painful and disabling neuromuscular ailments, exemplified but not limited to low back pain and migraine. The myofascial trigger point release therapy includes specific manipulations to muscles and connective tissue which reduce pain. Other chapters address the issues of providing long-range medical care to older adults burdened with chronic diseases, notably hypoxia-related pathologies and their sequalae, pointing to the advantages of care provided by a single primary care physician. Changing paradigm of care is essential in chronic atherosclerosis-based diseases like cardiovascular disorders or diabetes. Chapters provide results of international cohort studies on predictive factors for the long-range progress of such ailments based on anthropometric and lifestyle indicators. The book aims to meet the increasing interest and importance to patients of integrative health therapies. Medical rehabilitation and lifestyle changes increasingly gain scientific support in difficult-to-treat chronic conditions and should be integrated in a controlled manner into conventional medicine. The book is addressed to physiotherapists, medical scientists and clinicians, and allied healthcare professionals.
    Type of Medium: Online Resource
    Pages: VI, 109 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030996307
    Series Statement: Clinical and Experimental Biomedicine, 1375
    URL: https://doi.org/10.1007/978-3-030-99630-7
    DOI: 10.1007/978-3-030-99630-7
    DDC: 610.72
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    Biomedical Visualisation : Volume 11 (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Education Data processing. ; Image processing Digital techniques. ; Computer vision. ; Anatomy. ; Biomedical engineering. ; Computer simulation. ; Biomedical Research. ; Computers and Education. ; Computer Imaging, Vision, Pattern Recognition and Graphics. ; Anatomy. ; Biomedical Engineering and Bioengineering. ; Computer Modelling.
    Description / Table of Contents: Chapter 1. Creating Interactive Three-Dimensional Applications to Visualise Novel Stent Grafts That Aid in the Treatment of Aortic Aneurysms -- Chapter 2. Using Confocal Microscopy to Generate an Accurate Vascular Model for Use in Patient Education Animation -- Chapter 3. Methods and applications of 3D Patient-Specific Virtual Reconstructions in Surgery -- Chapter 4. Proof of Concept for the Use of Immersive Virtual Reality in Upper Limb Rehabilitation of Multiple Sclerosis Patients -- Chapter 5. Virtual Wards: A Rapid Adaptation to Clinical Attachments in MBChB During the COVID-19 Pandemic -- Chapter 6. Artificial Intelligence: Innovation to Assist in the Identification of Sono-anatomy for Ultrasound-Guided Regional Anaesthesia -- Chapter 7. A Systematic Review of Randomised Control Trials Evaluating the Efficacy and Safety of Open and Endoscopic Carpal Tunnel Release -- Chapter 8. Exploring Visualisation for Embryology Education: A Twenty-First-Century Perspective -- Chapter 9. How Artificial Intelligence and Machine Learning Is Assisting Us to Extract Meaning from Data on Bone Mechanics? -- Chapter 10. Visual Communication and Creative Processes Within the Primary Care Consultation -- Chapter 11. Digital 2D, 2.5D and 3D Methods for Adding Photo-Realistic Textures to 3D Facial Depictions of People from the Past -- Chapter 12. Teaching with Cadavers Outside of the Dissection Room Using Cadaveric Videos -- Chapter 13. A Novel Cadaveric Embalming Technique for Enhancing Visualisation of Human Anatomy -- Chapter 14. Assessing the Impact of Interactive Educational Videos and Screencasts Within Pre-clinical Microanatomy and Medical Physiology Teaching.
    Abstract: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualisation techniques and technologies for the historical and forensic settings. The chapters presented in this volume cover such a diverse range of topics, with something for everyone. We present here chapters on 3D visualising novel stent grafts to aid treatment of aortic aneuryms; confocal microscopy constructed vascular models in patient education; 3D patient specific virtual reconstructions in surgery; virtual reality in upper limb rehabilitation in patients with multiple sclerosis and virtual clinical wards. In addition, we present chapters in artificial intelligence in ultrasound guided regional anaesthesia; carpal tunnel release visualisation techniques; visualising for embryology education and artificial intelligence data on bone mechanics. Finally we conclude with chapters on visualising patient communication in a general practice setting; digital facial depictions of people from the past; instructor made cadaveric videos, novel cadaveric techniques for enhancing visualisation of the human body and finally interactive educational videos and screencasts. This book explores the use of technologies from a range of fields to provide engaging and meaningful visual representations of the biomedical sciences. It is therefore an interesting read for researchers, developers and educators who want to learn how visualisation techniques can be used successfully for a variety of purposes, such as educating students or training staff, interacting with patients and biomedical procedures in general.
    Type of Medium: Online Resource
    Pages: XVI, 343 p. 163 illus., 153 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030877798
    Series Statement: Advances in Experimental Medicine and Biology, 1356
    URL: https://doi.org/10.1007/978-3-030-87779-8
    DOI: 10.1007/978-3-030-87779-8
    DDC: 610.72
    Language: English
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    Nanoscale Engineering of Biomaterials: Properties and Applications (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Proteins. ; Biomaterials. ; Nanomedicine. ; Biomedical engineering. ; Biomedical Research. ; Biomaterials-Proteins. ; Nanomedicine and Nanotoxicology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Part 1 -- 1 Interactions between the physiological environment and titanium-based implant materials – from understanding to control -- 2 Nanoscale surface Engineering and Characterization of Biomaterial -- 3 Progress of Nanotechnology-based Detection and Treatment of Alzheimer’s Disease Biomarkers -- 4 Biomaterials: Types and Applications -- Part 2 -- 5 Additive Manufacturing of Ti and its alloy-based Bioimplants for Orthopaedic Applications -- 6 Physico-chemical Modifications of Magnesium and Alloys for Biomedical Applications -- 7 Metallic Foams in Bone Tissue Engineering -- 8 Surface modification of metallic biomaterials for cardiovascular cells regulation and biocompatibility improvement -- 9 Advancement of spinel ferrites for biomedical application -- Part 3 -- 10 Functionalized 3D bioactive polymeric materials in tissue engineering and regenerative medicine -- 11 Polymer matrixes used in wound healing applications. 12 Conductive Polymers for Cardiovascular Applications -- 13 Engineered polymeric materials/nanomaterials for growth factor/drug delivery in bone tissue engineering applications -- 14 Surface engineering of polymeric materials for bone tissue engineering -- 15 Antibacterial Surface Modification to Prevent Biofilm Formation on Polymeric Biomaterials -- 16 Polymer Surface Engineering in the Food Packaging Industry -- 17 Polymeric Membranes in Waste-water Treatment -- 18 Functionalized Fluoropolymer Membrane for Fuel Cell Applications -- Part 4 -- 19 Bioceramics for Biomedical Applications -- 20 Applications of nanomaterials in the textile industry -- 21 Properties and characterization of advanced composite materials -- 22 Properties and characterization of advanced composite materials -- 23 Nano composites application in sewage treatment and degradation of persistent pesticides used in agriculture -- 24 Biomimetic Mineralization of Electrospun PCL based Composite Nanofibrous Scaffold for hard tissue Engineering. .
    Abstract: This book provides a comprehensive overview of the latest advances in a wide range of biomaterials for the development of smart and advanced functional materials. It discusses the fundamentals of bio-interfacial interactions and the surface engineering of emerging biomaterials like metals and alloys, polymers, ceramics, and composites/nanocomposites. In turn, the book addresses the latest techniques and approaches to engineering material surfaces/interfaces in, e.g., implants, tissue engineering, drug delivery, antifouling, and dentistry. Lastly, it summarizes various challenges in the design and development of novel biomaterials. Given its scope, it offers a valuable source of information for students, academics, physicians and particularly researchers from diverse disciplines such as material science and engineering, polymer engineering, biotechnology, bioengineering, chemistry, chemical engineering, nanotechnology, and biomedical engineering for various commercial and scientific applications.
    Type of Medium: Online Resource
    Pages: X, 704 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811636677
    URL: https://doi.org/10.1007/978-981-16-3667-7
    DOI: 10.1007/978-981-16-3667-7
    DDC: 610.72
    Language: English
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    Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 2 : The Path to Bedside Management (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Neurology . ; Internal medicine. ; Immunology. ; Biomedical Research. ; Biomedical Research. ; Neurology. ; Internal Medicine. ; Immunology.
    Description / Table of Contents: Chapter 1. Malignant Glioma -- Chapter 2. Benign Glioma -- Chapter3. Meningioma and Other Meningeal Tumors -- Chapter4. Epondymomas in Pediatric and Adults -- Chapter5. Medulloblastomas in Pediatric and Adults -- Chapter6. Benign and Malignant Tumors of The Pineal Region -- Chapter7. The Tumors of Choroid Plexus and Other Ventricular Tumors -- Chapter8. Embryonal Tumors of The Central Nervous System with Multilayered Rosettes and Atypical Teratoid/Rhabdoid Tumors -- Chapter9. Glioneuronal and Neuronal Tumors of the Central Nervous System -- Chapter10. Benign and Malignant Tumors of the Pituitary Gland -- Chapter11. Craniopharyngioma in Pediatric and Adults -- Chapter12. Schwannomas of Brain and Spinal Cord -- Chapter13. Other Nerve-Sheet Tumors of Brain and Spinal Cord -- Chapter14. Hemangioblastomas and Other Vascular Originating Tumors of Brain or Spinal Cord -- Chapter15. Brain and Spinal Cord Tumors of Embryonic Origin -- Chapter16. Brain and Spinal Tumors Originating from the Germ Line Cells -- Chapter17. Benign Brain and Spinal Tumors Originating from Bone or Cartilage -- Chapter18. Benign Spinal Tumors -- Chapter19. Other Less Prevalent Tumors of the Central Nervous System -- Chapter20. Brain and/or Spinal Cord Tumors Accompanied with Other Diseases or Syndromes -- Chapter21. Psychological and Psychiatric Aspects of Brain and Spinal Cord Tumors -- Chapter22. A Brief Explanation on Surgical Approaches for Treatment of Different Brain Tumors.
    Abstract: This book aims to gather the current knowledge regarding different aspects of brain and spinal cord tumors in order to more efficiently help the patients. Brain tumors comprise about 5–9% of all human neoplasms; and the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. The more we know about the nature and characteristic of brain and spinal cord tumors, the more precise decision could be made for each patient, in order to reach the best outcome. While surgical resection, chemotherapy, and radiotherapy have been considered as the standards of care for benign and/or malignant CNS tumors since a long time ago, new therapeutic approaches such as immunotherapy have been recently proposed to be considered for treatment of CNS tumors, especially as in some cases, the tumors might be inoperable or the patient may not benefit from other treatment modalities after several recurrences. The second volume of the book focuses on clinical aspects of these tumors. Accordingly, the most important brain and spinal cord tumors are specifically discussed in each chapter based on a rational outlining for all chapter in this volume: Background and epidemiology, genetics, immunology and molecular biology, histopathology and morphology, imaging and radiologic features, clinical manifestations, therapeutic approaches, surgical intervention, chemotherapy and radiotherapy, new therapeutic modalities, follow-up, and prognosis. The chapters of this volume discuss the following pathologies of brain and spinal cord tumors: malignant glioma, benign glioma, meningiomas and other meningeal tumors, ependymomas, medulloblastomas, pineal tumors, choroid plexus and ventricular tumors, neuroectodermal tumors of CNS, neuroepithelial tumors of CNS, pituitary gland tumors, craniopharyngioma, schwannomas and nerve-sheet tumors, hemangioblastomas and other vascular originating tumors, brain and spinal tumors of embryonic origin, germ line cell tumors, malignant bone or cartilage-originating tumors of brain and spine, benign bone or cartilage-originating tumors of brain and spine, brain tumors affecting the orbit globe and orbit tumors affecting the brain, CNS lymphomas, metastatic lesions of the brain and spine, malignant spinal tumors, benign spinal tumors, brain and/or spinal cord tumors accompanied with other diseases or syndromes, psychological and psychiatric aspects of brain and spinal cord tumors, a brief explanation on surgical approaches for treatment of different brain tumors. This volume of book is useful for physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists, and neuroradiologists.
    Type of Medium: Online Resource
    Pages: XXIX, 739 p. 287 illus., 159 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031237058
    Series Statement: Advances in Experimental Medicine and Biology, 1405
    URL: https://doi.org/10.1007/978-3-031-23705-8
    DOI: 10.1007/978-3-031-23705-8
    DDC: 610.72
    Language: English
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    Novel Technologies in Biosystems, Biomedical & Drug Delivery (2023)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Drug delivery systems. ; Genetics Research. ; Imaging systems in biology. ; Biology Technique. ; Biomedical Research. ; Drug Delivery. ; Genetics Research. ; Biological Imaging. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Editorial: Biosystems -- 2. Potential of Biotechnology in cancer management -- 3. Biosimilars: Promising and Rapidly Emerging Biotherapeutics -- 4. Applications of Nanomaterials in Medicine: Current status and future scope -- 5. Biomedical Applications of Nanofluids in Drug Delivery.
    Abstract: The book gives an insight into the theoretical background, conceptual understanding, latest developments, and applications in the field of pharmaceuticals in general and drug design, discovery, biosystems, and biomedical and drug delivery technologies in particular . Knowledge is drawn from various disciplines such as Chemistry, Biology, Material Science and Engineering, Statistics, Biomedicine, and Genetics . A host of applications like bio-imaging, novel biological agents, testing, characterization and validation of drugs, computer-based models in drug design, and application of statistical tools in data analysis, design, and development of drug delivery systems, and ecosystems are dealt with in detail. The said book undoubtedly confirms the requirements of the postgraduate students, research scholars, academicians, scientists, and researchers from the academia, pharmaceutical, biotechnology, and chemical engineering domain. The book covers a conceptual understanding of the exploration of drugs in tandem with intended uses, sound ecosystem development, and carriers for drug and supplement delivery.
    Type of Medium: Online Resource
    Pages: XX, 289 p. 58 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819952816
    URL: https://doi.org/10.1007/978-981-99-5281-6
    DOI: 10.1007/978-981-99-5281-6
    DDC: 610.72
    Language: English
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    Cognitive Functioning in Schizophrenia: Leveraging the RDoC Framework (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical sciences. ; Drug development. ; Pharmacology. ; Genetics Research. ; Clinical medicine Research. ; Biochemical markers. ; Translational Research. ; Preclinical Research. ; Pharmacology. ; Genetics Research. ; Clinical Research. ; Biomarkers.
    Description / Table of Contents: MATRICS – an update -- Cognitive [Computational] Neuroscience Test Reliability and Clinical Applications for Serious mental illness (CNTRaCS) Consortium: Progress and Future Directions -- Attention in Schizophrenia -- Perceptual Functioning -- Episodic Memory and Schizophrenia: From Characterization of Relational Memory Impairments to Neuroimaging Biomarkers -- Working Memory in People with Schizophrenia -- "Targeting Frontal Gamma Activity with Neurofeedback to Improve Working Memory in Schizophrenia" -- Cognitive Dysfunction as a Risk Factor for Psychosis -- Environmental Risk Factors and Cognitive Outcomes in Psychosis: Pre-, Perinatal, and Early Life Adversity -- Developmental manipulation-induced changes in cognitive functioning -- Genetic underpinnings of cognitive dysfunction in schizophrenia -- Primate models of cognitive deficit re schizophrenia -- Olfactory cognitive deficits -- Medication/Anticholinergic burden impacting cognition in schizophrenia An Update on Treatment of Cognitive Impairment Associated with Schizophrenia -- Cannabis & cognition -- Sex/gender differences -- Neuroinflammation linked to cognition.
    Abstract: This book highlights recent research investigating psychological and neural mechanisms contributing to dysfunctional cognition in people with schizophrenia. The work on cognition in schizophrenia from the past 20 years is highlighted, and emphasis throughout the book is placed on utilizing the Research Domain Criterion framework. Thus, the book also covers animals work relevant to schizophrenia that assesses behaviors utilizing the same framework, enabling mechanistic studies and highlighting potential biomarkers of function. The book also includes important areas of research in the field of cognitive function in schizophrenia that have received less attention, such as cognitive side-effects of current treatments and olfactory-based cognition. Altogether, the book provides a translational perspective of the most-up-to-date research on cognition in schizophrenia to-date, but with identification of novel directions for research initiatives.
    Type of Medium: Online Resource
    Pages: XII, 497 p. 70 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031264412
    Series Statement: Current Topics in Behavioral Neurosciences, 63
    URL: https://doi.org/10.1007/978-3-031-26441-2
    DOI: 10.1007/978-3-031-26441-2
    DDC: 610.72
    Language: English
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    Molecular Medicine : How Science Works (2023)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Genomics. ; Cancer. ; Immunology. ; Nutrition   . ; Physiology. ; Biomedical Research. ; Genomics. ; Cancers. ; Immunology. ; Nutrition. ; Physiology.
    Description / Table of Contents: 1. The human genome and its variations -- 2. Gene expression and chromatin -- 3. The basal transcriptional machinery -- 4. Transcription factors and signal transduction -- 5. A key transcription factor family: Nuclear receptors -- 6. DNA methylation -- 7. Histone modifications -- 8. Chromatin remodeling and organization -- 9. Regulatory impact of non-coding RNA -- 10. Genome-wide principles of gene regulation -- 11. Epigenetics in development -- 12. Epigenetics and aging -- 13. Epigenetics and disease -- 14. Cells and tissues of the immune system -- 15. Innate immunity and inflammation -- 16. Adaptive immunity and antigen receptor diversity -- 17. B cell immunity: BCRs, antibodies and their effector functions -- 18. Antigen-presenting cells and MHCs -- 19. T cell immunity: TCRs and their effector functions -- 20. Immunity to bacterial pathogens and the microbiome -- 21. Immunity to viral pathogens and the virome -- 22. Tolerance and transplantation immunology -- 23. Immunological hypersensitivities: Allergy and autoimmunity -- 24. Introduction to cancer -- 25. Oncogenes, signal transduction and the hallmarks of cancer -- 26 Tumor suppressor genes and cell fate control -- 27. Multistep tumorigenesis and genome instability -- 28. Cancer genomics -- 29. Cancer epigenomics.-30. Aging and cancer -- 31. Tumor microenvironment -- 32 Metastasis and cachexia -- 33. Cancer immunology -- 34 Architecture of cancer therapies -- 35 Nutrition and common diseases -- 36 Interference of the human genome with nutrients -- 37. Nutritional epigenetics, signaling and aging -- 38. Chronic inflammation and metabolic stress -- 39. Obesity -- 40. Insulin resistance and diabetes -- 41. Heart disease and the metabolic syndrome -- 42 Epigenetics, inflammation and disease.
    Abstract: The fascinating area of molecular medicine provides a molecular and cellular description of health and disease. Starting with the understanding of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin, this book will provide an fundamental basis of nearly all processes in physiology, both in health as well as in most common disorders, such as cancer, diabetes as well as in autoimmune diseases. Most non-communicable human diseases have a genetic (= inherited) as well as an epigenetic component. The later one is based on our lifestyle choices and environmental exposures. Many common diseases, such as type 2 diabetes, can be explained only to some 20% via a genetic predisposition. We cannot change the genes that we are born with but we can take care of the remaining 80% being primarily based on our epigenome. Therefore, there is a high level of individual responsibility for staying healthy. Thus, not only biologists and biochemists should be aware of this topic, but all students of biomedical disciplines will benefit from being introduced into the concepts of molecular medicine. This will provide them with a good basis for their specialized disciplines of modern life science research. The book is subdivided into 42 chapters that are linked to a series of lecture courses in “Molecular Medicine and Genetics”, “Molecular Immunology”, “Cancer Biology” and “Nutrigenomics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. This book represents an updated version and fusion of the books textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8). “Molecular Immunology: How Science Works” (ISBN 978-3-030-XXX), “Cancer Biology: How Science Works” (ISBN 978-3-030-75699-4) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4). By combining basic understanding of cellular mechanism with clinical examples, the authors hope to make this textbook a personal experience. A glossary in the appendix will explain the major specialist’s terms.
    Type of Medium: Online Resource
    Pages: XXXIV, 700 p. 301 illus., 300 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031271335
    URL: https://doi.org/10.1007/978-3-031-27133-5
    DOI: 10.1007/978-3-031-27133-5
    DDC: 610.72
    Language: English
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    Machine Learning in Medicine – A Complete Overview (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical sciences. ; Statistics . ; Social sciences. ; Humanities. ; Biomedical Research. ; Health Sciences. ; Statistics. ; Humanities and Social Sciences.
    Description / Table of Contents: Preface -- Section I Cluster and Classification Models -- Hierarchical Clustering and K-means Clustering to Identify Subgroups in Surveys (50 Patients) -- Density-based Clustering to Identify Outlier Groups in Otherwise Homogeneous Data (50 Patients) -- Two Step Clustering to Identify Subgroups and Predict Subgroup Memberships in Individual Future Patients (120 Patients) -- Nearest Neighbors for Classifying New Medicines (2 New and 25 Old Opioids) -- Predicting High-Risk-Bin Memberships (1445 Families) -- Predicting Outlier Memberships (2000 Patients) -- Data Mining for Visualization of Health Processes (150 Patients) -- Trained Decision Trees for a More Meaningful Accuracy (150 Patients) -- Typology of Medical Data (51 Patients) -- Predictions from Nominal Clinical Data (450 Patients) -- Predictions from Ordinal Clinical Data (450 Patients) -- Assessing Relative Health Risks (3000 Subjects) -- Measurement Agreements (30 Patients) -- Column Proportions for Testing Differences between Outcome Scores (450 Patients) -- Pivoting Trays and Tables for Improved Analysis of Multidimensional Data (450 Patients) -- Online Analytical Procedure Cubes for a More Rapid Approach to Analyzing Frequencies (450 Patients) -- Restructure Data Wizard for Data Classified the Wrong Way (20 Patients) -- Control Charts for Quality Control of Medicines (164 Tablet Desintegration Times) -- Section II (Log) Linear Models -- Linear, Logistic, and Cox Regression for Outcome Prediction with Unpaired Data (20, 55, and 60 Patients) -- Generalized Linear Models for Outcome Prediction with Paired Data (100 Patients and 139 Physicians) -- Generalized Linear Models for Predicting Event-Rates (50 Patients) -- Factor Analysis and Partial Least Squares (PLS) for Complex-Data Reduction (250 Patients) -- Optimal Scaling of High-sensitivity Analysis of Health Predictors (250 Patients) -- Discriminant Analysis for Making a Diagnosis from Multiple Outcomes (45 Patients) -- Weighted Least Squares for Adjusting Efficacy Data with Inconsistent Spread (78 Patients) -- Partial Correlations for Removing Interaction Effects from Efficacy Data (64 Patients) -- Canonical Regression for Overall Statistics of Multivariate Data (250 Patients) -- Multinomial Regression for Outcome Categories (55 Patients) -- Various Methods for Analyzing Predictor Categories (60 and 30 Patients) -- Random Intercept Models for Both Outcome and Predictor Categories (55 Patients) -- Automatic Regression for Maximizing Linear Relationships (55 Patients) -- Simulation Models for Varying Predictors (9000 Patients) -- Generalized Linear Mixed Models for Outcome Prediction from Mixed Data (20 Patients) -- Two Stage Least Squares for Linear Models with Problematic Predictors (35 Patients) -- Autoregressive Models for Longitudinal Data (120 Monthly Population Records) -- Variance Components for Assessing the Magnitude of Random Effects (40 Patients) -- Ordinal Scaling for Clinical Scores with Inconsistent Intervals (900 Patients) -- Loglinear Models for Assessing Incident Rates with Varying Incident Risks (12 Populations) -- Loglinear Models for Outcome Categories (445 Patients) -- More on Polytomous Outcome Regressions (450 Patients) -- Heterogeneity in Clinical Research: Mechanisms Responsible (20 Studies) -- Performance Evaluation of Novel Diagnostic Tests (650 and 588 Patients) -- Quantile - Quantile Plots, a Good Start for Looking at Your Medical Data (50 Cholesterol Measurements and 52 Patients) -- Rate Analysis of Medical Data Better than Risk Analysis (52 Patients) -- Trend Tests Will Be Statistically Significant if Traditional Tests Are not (30 and 106 Patients) -- Doubly Multivariate Analysis of Variance for Multiple Observations from Multiple Outcome Variables (16 Patients) -- Probit Models for Estimating Effective Pharmacological Treatment Dosages (14 Tests) -- Interval Censored Data Analysis for Assessing Mean Time to Cancer Relapse (51 Patients) -- Structural Equation Modeling with SPSS Analysis of Moment Structures (Amos) for Cause Effect Relationships I (35 Patients) -- Structural Equation Modeling with SPSS Analysis of Moment Structures (Amos) for Cause Effect Relationships II (35 Patients) -- Firth's Bias-adjusted Estimates for Biased Logistic Data Models (23 Challenger launchings) -- Omics Research (125 Patients, 24 Predictor Variables) -- Sparse Canonical Correlation Analysis (12209 Genes in 45 Glioblastoma Carriers) -- Eigenvalues, Eigenvectors and Eigenfunctions (45 and 250 Patients) -- Section III Rules Models -- Neural Networks for Assessing Relationships that are Typically Nonlinear (90 Patients) -- Complex Samples Methodologies for Unbiased Sampling (9,678 Persons) -- Correspondence Analysis for Identifying the Best of Multiple Treatments in Multiple Groups (217 Patients) -- Decision Trees for Decision Analysis (1004 and 953 Patients) -- Multidimensional Scaling for Visualizing Experienced Drug Efficacies (14 Pain-killers and 42 Patients) -- Stochastic Processes for Long Term Predictions from Short Term Observations -- Optimal Binning for Finding High Risk Cut-offs (1445 Families) -- Conjoint Analysis for Determining the Most Appreciated Properties of Medicines to Be Developed (15 Physicians) -- Item Response Modeling for Analyzing Quality of Life with Better Precision (1000 Patients) -- Survival Studies with Varying Risks of Dying (50 and 60 Patients) -- Fuzzy Logic for Improved Precision of Pharmacological Data Analysis (9 Induction Dosages) -- Automatic Data Mining for the Best Treatment of a Disease (90 Patients) -- Pareto Charts for Identifying the Main Factors of Multifactorial Outcomes (2000 Admissions to Hospital) -- Radial Basis Neural Networks for Multidimensional Gaussian Data (90 persons) -- Automatic Modeling for Drug Efficacy Prediction (250 Patients) -- Automatic Modeling for Clinical Event Prediction (200 Patients) -- Automatic Newton Modeling in Clinical Pharmacology (15 Alfentanil dosages, 15 Quinidine time-concentration relationships) -- Spectral Plots for High Sensitivity Assessment of Periodicity (6 Years’ Monthly C Reactive Protein Levels) -- Runs Test for Identifying Best Analysis Models (21 Estimates of Quantity and Quality of Patient Care) -- Evolutionary Operations for Health Process Improvement (8 Operation Room Settings) -- Bayesian Networks for Cause Effect Modeling (600 Patients) -- Support Vector Machines for Imperfect Nonlinear Data (200 Patients) -- Multiple Response Sets for Visualizing Clinical Data Trends (811 Patient Visits) -- Protein and DNA Sequence Mining -- Iteration Methods for Crossvalidation (150 Patients) -- Testing Parallel-groups with Different Sample Sizes and Variances (5 Parallel-group Studies) -- Association Rules between Exposure and Outcome (50 and 60 Patients) -- Confidence Intervals for Proportions and Differences in Proportions (100 and 75 Patients) -- Ratio Statistics for Efficacy Analysis of New Drugs 50 Patients) -- Fifth Order Polynomes of Circadian Rhythms (1 Patient) -- Gamma Distribution for Estimating the Predictors of Medical Outcomes (110 Patients) -- Index.
    Abstract: Adequate health and health care is no longer possible without proper data supervision from modern machine learning methodologies like cluster models, neural networks, and other data mining methodologies. The current book is the first publication of a complete overview of machine learning methodologies for the medical and health sector, and it was written as a training companion, and as a must-read, not only for physicians and students, but also for any one involved in the process and progress of health and health care. In this second edition the authors have removed the textual errors from the first edition. Also, the improved tables from the first edition, have been replaced with the original tables from the software programs as applied. This is, because, unlike the former, the latter were without error, and readers were better familiar with them. The main purpose of the first edition was, to provide stepwise analyses of the novel methods from data examples, but background information and clinical relevance information may have been somewhat lacking. Therefore, each chapter now contains a section entitled "Background Information". Machine learning may be more informative, and may provide better sensitivity of testing than traditional analytic methods may do. In the second edition a place has been given for the use of machine learning not only to the analysis of observational clinical data, but also to that of controlled clinical trials. Unlike the first edition, the second edition has drawings in full color providing a helpful extra dimension to the data analysis. Several machine learning methodologies not yet covered in the first edition, but increasingly important today, have been included in this updated edition, for example, negative binomial and Poisson regressions, sparse canonical analysis, Firth's bias adjusted logistic analysis, omics research, eigenvalues and eigenvectors. .
    Type of Medium: Online Resource
    Pages: XXX, 667 p. 548 illus., 131 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030339708
    URL: https://doi.org/10.1007/978-3-030-33970-8
    DOI: 10.1007/978-3-030-33970-8
    DDC: 610.72
    Language: English
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  • 94
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    Trends of Artificial Intelligence and Big Data for E-Health (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical care. ; Quantitative research. ; Artificial intelligence Data processing. ; Health services administration. ; Bioinformatics. ; Biomedical Research. ; Health Care. ; Data Analysis and Big Data. ; Data Science. ; Health Care Management. ; Bioinformatics.
    Description / Table of Contents: 1. AI and Big Data for Intelligent Health: Promise and Potential -- 2. AI and Big Data for Cancer Segmentation, Detection and Prevention -- 3. Radiology, AI and Big Data: Challenges and Opportunities for Medical Imaging -- 4. Neuroradiology: Current Status and Future Prospects -- 5. Big Data and AI in Cardiac Imaging -- 6. Artificial Intelligence and Big data for COVID-19 Diagnosis -- 7. AI and Big Data for Drug Discovery -- 8. Blockchain of IoMT (BIoMT): A New Paradigm for COVID-19 Pandemic: Application, Architecture, Technology, and Security -- 9. AI and Big Data for Therapeutic Strategies in Psychiatry -- 10. Distributed Learning in Healthcare -- 11. Cybersecurity in Healthcare -- 12. Radiology and Radiomics: Towards oncology Prediction with IA and Big Data.
    Abstract: This book aims to present the impact of Artificial Intelligence (AI) and Big Data in healthcare for medical decision making and data analysis in myriad fields including Radiology, Radiomics, Radiogenomics, Oncology, Pharmacology, COVID-19 prognosis, Cardiac imaging, Neuroradiology, Psychiatry and others. This will include topics such as Artificial Intelligence of Thing (AIOT), Explainable Artificial Intelligence (XAI), Distributed learning, Blockchain of Internet of Things (BIOT), Cybersecurity, and Internet of (Medical) Things (IoTs). Healthcare providers will learn how to leverage Big Data analytics and AI as methodology for accurate analysis based on their clinical data repositories and clinical decision support. The capacity to recognize patterns and transform large amounts of data into usable information for precision medicine assists healthcare professionals in achieving these objectives. Intelligent Health has the potential to monitor patients at risk with underlying conditions and track their progress during therapy. Some of the greatest challenges in using these technologies are based on legal and ethical concerns of using medical data and adequately representing and servicing disparate patient populations. One major potential benefit of this technology is to make health systems more sustainable and standardized. Privacy and data security, establishing protocols, appropriate governance, and improving technologies will be among the crucial priorities for Digital Transformation in Healthcare.
    Type of Medium: Online Resource
    Pages: X, 251 p. 67 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031111990
    Series Statement: Integrated Science, 9
    URL: https://doi.org/10.1007/978-3-031-11199-0
    DOI: 10.1007/978-3-031-11199-0
    DDC: 610.72
    Language: English
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  • 95
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    Mammalian Sterols : Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Biochemistry. ; Internal medicine. ; Lipids. ; Bioinformatics. ; Medical genetics. ; Biomedical Research. ; Chemical Biology. ; Internal Medicine. ; Lipidology. ; Computational and Systems Biology. ; Medical Genetics.
    Description / Table of Contents: Sterols from the post-lanosterol part of cholesterol synthesis – novel signaling players -- Genetic variability in cholesterol metabolism -- Side-chain oxidized oxysterols in health and disease -- Bile acids and TGR5 (Gpbar1) signaling -- Bile acids as regulatory signalling molecules -- Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: nuclear receptors LXR, FXR, and fibroblast growth factor 15/19 -- Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids.
    Abstract: This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as medical doctors in hepatology.
    Type of Medium: Online Resource
    Pages: V, 171 p. 57 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030396848
    URL: https://doi.org/10.1007/978-3-030-39684-8
    DOI: 10.1007/978-3-030-39684-8
    DDC: 610.72
    Language: English
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  • 96
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    Advances in Nanomaterials-based Cell Biology Research (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Nanobiotechnology. ; Biomedical Research. ; Cell Biology. ; Nanobiotechnology.
    Description / Table of Contents: Chapter 1. Nanomaterials and Stem Cells for Bone Tissue Engineering -- Chapter 2. The Application of Nanomaterial in Skeletal Muscle Regeneration -- Chapter 3. Application of Nanomaterials in Neurodegenerative Diseases -- Chapter 4. Application of Nano Drug Delivery Systems in Inhibition of Tumors and Cancer Stem Cells -- Chapter 5. The Application and Problems of Tetrahedral Framework Nucleic Acids as a Drug Carrier in Biomedicine Fields -- Chapter 6. Research Progress on Antibacterial Application with Nucleic Acid and Nucleic Acid Materials -- Chapter 7. The Application of DNA Nanostructures in Vaccine Technology.-.
    Abstract: This book aims to comprehensively summarize the current research status of nanomaterials and cell biology. It highlights the biological effects and biomedical applications of nanomaterials for specific diseases, bone tissue engineering, and skeletal muscle regeneration. It also provides the details of the biomedical applications of nucleic acid nanomaterials in drug delivery carriers, antimicrobial therapy, vaccine, and neurodegenerative diseases. Therefore, this book renders the audience a better understanding of nanomaterials along with the diverse applications in the cell biology field from recent works to perspectives.
    Type of Medium: Online Resource
    Pages: IX, 219 p. 13 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811626661
    URL: https://doi.org/10.1007/978-981-16-2666-1
    DOI: 10.1007/978-981-16-2666-1
    DDC: 610.72
    Language: English
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  • 97
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    Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 1 : Neuroimmunology and Neurogenetics (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Biomedical Research. ; Biomedical Research. ; Biomedical Research. ; Medical Genetics.
    Description / Table of Contents: Chaptre 1. Brain and Spinal Cord Tumors Among the Life-Threatening Health Problems: An Introduction -- Chaptre 2. Epidemiology of Brain and Spinal Cord Tumors -- Chaptre 3. The Role of Neuro-inflammation and Innate Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 4. The Role of Cellular Immunity and Adaptive Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 5. Immunotherapy as a New Therapeutic Approach for Brain and Spinal Cord Tumors -- Chaptre 6. Cell of Origin of Brain and Spinal Cord Tumors -- Chaptre 7. The Role of Bioinformatics and Imaging Models in Tumorigenesis and Treatment Response of Brain and Spinal Cord Neoplasms -- Chaptre 8. The Role of Epigenetics in Brain and Spinal Cord Tumors -- Chaptre 9. Stem Cells and Targeted Gene Therapy in Brain and Spinal Cord Tumors -- Chaptre 10. Nutrition and Diet: A Double-Edged Sword in Development and Treatment of Brain Tumors -- Chaptre 11. The Role of Nanotechnology in Brain Tumors -- Chaptre 12. The Role of Nanotechnology in Spinal Cord Tumors -- Chaptre 13. The Economic Burden of Malignant Brain Tumors.
    Abstract: Brain tumors comprise about 5–9% of all human neoplasms; and interestingly the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. Besides to the morphologic and histopathologic characteristics, and as each pathologic states first starts with molecular alterations, each tumor may have its own story in the matter of activating tumorigenesis pathways and having specific molecular characteristics. Importantly, the molecular classification of tumors has been highly considered in the past few decades for taking the most appropriate therapeutic approach. On the other hand, the tumors shall have tumor-scape mechanisms preventing the immunologic system to eliminate its invasion. The failure of innate and acquired immune system to defeat tumorigenesis mechanisms would consequently result in tumor development. Interestingly, the neuro-immunologic mechanism plays a role in development of psychiatric manifestations of brain tumors as well. Taking all these to account, the different arms of innate immunity, acquired immunity, and genetics have been approached to defeat development and/or progression of such tumors. Accordingly, the activation immunotherapeutic approaches focus on activating or strengthening the anti-tumor immunologic pathways in order to assist the weakened immune system to defeat the tumor (such as Dendritic cell vaccination, DNA vaccines, peptide vaccines, viral vector-based vaccines, monoclonal antibodies, and CAR T-cell therapy). In addition to immunologic components of brain and spinal cord tumors, numerous genes and genetic pathways have been recognized to take part in tumorigenesis. Taking these non-immune genetic pathways to account, some other therapeutic approaches such as stem cell therapy and gene therapy have been developed in the new era of cancer treatment. Moreover, and besides the biologic and medical aspects of these tumors, different physical/mathematical models have been proposed to either explain or predict tumor behavior. Such models would be advantageous in developing new therapeutic modalities in pre-clinical stages and enter new eras in cancer treatment. The first book of Human Brain and Spinal Cord Tumors, Neuro-immunology and Neuro-genetics, will mainly discuss the neuro-immunology and neurogenetic pathways associated with development of brain and spinal cord tumor. After a short introduction chapter, this book will focus on the role of innate and acquired immunity on development of these tumors and then the immunotherapeutic approaches to defeat these tumorigenesis mechanisms. This book will then focus on genetic aspects of brain and spinal cord tumors and bioinformatics models to describe the behavioral patterns of these tumors, as well as associated therapeutic approaches such as stem cell therapy and gene therapy. This volume of book could be useful for experts in basic sciences, mainly geneticists and immunologists, and also physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists and neuroradiologists.
    Type of Medium: Online Resource
    Pages: XX, 231 p. 30 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031147326
    Series Statement: Advances in Experimental Medicine and Biology, 1394
    URL: https://doi.org/10.1007/978-3-031-14732-6
    DOI: 10.1007/978-3-031-14732-6
    DDC: 610.72
    Language: English
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  • 98
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    Design of Experiments and Advanced Statistical Techniques in Clinical Research (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Statistics . ; Biometry. ; Biomedical Research. ; Applied Statistics. ; Biostatistics.
    Description / Table of Contents: Design of Clinical Research and its Practical Approach -- Advanced Design of Experiment Approach to Clinical and Medical Research -- Random Forest and Concept of Decision Tree Model -- Application of Machine Learning in Medical Research -- Statistical Genetic and its Application in Drug Trail -- Statistical Implications for Estimation of Genetic Traits in Human Vaccine Trail -- Statistical Implications and its Practical Approach to Research Methodology -- Statistical Models Approach to Life Threatened Diseases -- Meta Analysis in Clinical and Life Science Research -- Pharmokinitic and Statistical Modelling -- Imputation Methods Approach to Clinical and Life Science Research Data Sets -- Ethical Perspective of Medical Research.
    Abstract: Recent Statistical techniques are one of the basal evidence for clinical research, a pivotal in handling new clinical research and in evaluating and applying prior research. This book explores various choices of statistical tools and mechanisms, analyses of the associations among different clinical attributes. It uses advanced statistical methods to describe real clinical data sets, when the clinical processes being examined are still in the process. This book also discusses distinct methods for building predictive and probability distribution models in clinical situations and ways to assess the stability of these models and other quantitative conclusions drawn by realistic experimental data sets. Design of experiments and recent posthoc tests have been used in comparing treatment effects and precision of the experimentation. This book also facilitates clinicians towards understanding statistics and enabling them to follow and evaluate the real empirical studies (formulation of randomized control trial) that pledge insight evidence base for clinical practices. This book will be a useful resource for clinicians, postgraduates scholars in medicines, clinical research beginners and academicians to nurture high-level statistical tools with extensive scope.
    Type of Medium: Online Resource
    Pages: XXXV, 356 p. 190 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811582103
    URL: https://doi.org/10.1007/978-981-15-8210-3
    DOI: 10.1007/978-981-15-8210-3
    DDC: 610.72
    Language: English
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  • 99
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    Engineering Biomaterials for Neural Applications (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Biomedical engineering. ; Neurosciences. ; Biotechnology. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Biomedical Devices and Instrumentation. ; Neuroscience. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Scaffolds for promoting neural repair -- Chapter 2. Composites for nerve regeneration -- Chapter 3. Configurable models of the blood-brain barrier -- Chapter 4. Engineering nerve conduits -- Chapter 5. Flexible electronics for stem cell differentiation -- Chapter 6. Nanosensors for brain chemistry -- Chapter 7. Nanomaterials for imaging the brain ECS -- Chapter 8. Microfluidics for analysis of neuronal development -- Chapter 9. Multiple particle tracking measurements of extracellular matrix dysregulation -- Chapter 10. Bioresponsive nanomaterials for treatment of CNS disease -- Chapter 11. Redox regulation for controlling cell fate -- Chapter 12. Polymersome delivery of CRISPR-based therapies -- Chapter 13. Multifunctional polymers for targeted delivery -- Chapter 14. Theranostic nanomaterials for brain injury.
    Abstract: This contributed volume explores the ways in which researchers engineer new biomaterials for the challenging problems of the peripheral and central nervous systems. These biomaterials are uniquely positioned for use in creating in vitro models of injury and disease, testing therapeutic treatments, understanding neural development, and mapping the multi-scalar environment of the brain. This book informs readers from biology, chemistry, materials science, engineering, and neuroscience on cutting edge research in engineering technologies, from fundamental material development through pre-clinical studies. The book also highlights target applications in three areas of research: (1) engineering neural models and materials, (2) probing biological underpinnings of neurological function and disease, and (3) designing therapeutic and diagnostic treatments for neurological disease. .
    Type of Medium: Online Resource
    Pages: VIII, 353 p. 64 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031114090
    URL: https://doi.org/10.1007/978-3-031-11409-0
    DOI: 10.1007/978-3-031-11409-0
    DDC: 610.72
    Language: English
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  • 100
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    Biomedical Visualisation : Volume 10 (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Education Data processing. ; Image processing Digital techniques. ; Computer vision. ; Anatomy. ; Computer simulation. ; Biomedical engineering. ; Biomedical Research. ; Computers and Education. ; Computer Imaging, Vision, Pattern Recognition and Graphics. ; Anatomy. ; Computer Modelling. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Evaluating the Efficacy and Optimisation of the Peer-led Flipped Model Using TEL Resources Within Neuroanatomy -- Observation of Patients’ 3D Printed Anatomical Features and 3D Visualisation Technologies Improve Spatial Awareness for Surgical Planning and in-Theatre Performance -- Pandemics, Protests and Pronouns: The Changing Landscape of Biomedical Visualisation and Education -- What Not to Do with PPE: A Digital Application to Raise Awareness of Proper PPE Protocol -- The Embryonic re-Development of an Anatomy Museum -- Visualising the Link Between Carpal Bones and their Etymologies -- Augmented Reality Application of Schizocosa Ocreata: A tool for Reducing Fear of Arachnids Through Public Outreach -- The Surgical Art Face©: Developing a Bespoke Multimodal Face Model for Reconstructive Surgical Education -- Modernizing Medical Museums Through the 3D Digitization of Pathological Specimens -- An Introduction to Biomedical Computational Fluid Dynamics.
    Abstract: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualisation techniques and technologies for the historical and forensic settings. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences. The chapters presented in this volume cover such a diverse range of topics, with something for everyone. We present here chapters on technology enhanced learning in neuroanatomy; 3D printing and surgical planning; changes in higher education utilising technology, decolonising the curriculum and visual representations of the human body in education. We also showcase how not to use protective personal equipment inspired by the pandemic; anatomical and historical visualisation of obstetrics and gynaecology; 3D modelling of carpal bones and augmented reality for arachnid phobias for public engagement. In addition, we also present face modelling for surgical education in a multidisciplinary setting, military medical museum 3D digitising of historical pathology specimens and finally computational fluid dynamics. .
    Type of Medium: Online Resource
    Pages: XVI, 223 p. 141 illus., 125 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030769512
    Series Statement: Advances in Experimental Medicine and Biology, 1334
    URL: https://doi.org/10.1007/978-3-030-76951-2
    DOI: 10.1007/978-3-030-76951-2
    DDC: 610.72
    Language: English
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