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  • 1
    Keywords: Cancer. ; Molecular genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology. ; Cancer Biology. ; Molecular Genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology.
    Description / Table of Contents: Chapter 1. Potential Role of Biomarkers, Biosensors, Technologies and Computational Methods in Early Detection of Gastrointestinal Cancer -- Chapter 2. Biomarkers as the Promising Tools for Early Detection of Gastrointestinal Cancer -- Chapter 3. Development and Evaluation of Biomarkers for Early Detection of Cancer -- Chapter 4. Prognostic Molecular Markers for Gastrointestitinal cancer -- Chapter 5. Metabolic Markers for Early Detection of Gastrointestinal Cancer -- Chapter 6. Current Status of MicroRNA-based Biomarkers for Gastric Cancer -- Chapter 7. Genetic Susceptibility Markers of Gastrointestinal Cancer -- Chapter 8. Approaches For Early Detection Of Gastrointestinal Cancer -- Chapter 9. Biosensors and its Applications for Early Detection of Gastrointestitinal Cancer -- Chapter 10. Application of Nanotechnology in Early Detection of Gastrointestinal Cancer -- Chapter 11. Genetic Marker Identification for the Detection of Early-Onset Gastrointestitinal Cancer Through Genome Wide Association Studies -- Chapter 12. Big Data Analytics to Discover Diagnostics and Therapeutics for Gastrointestitinal Cancer -- Chapter 13. System Biology Approach for Early Prognosis of Gastrointestinal Cancer.
    Abstract: This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.
    Type of Medium: Online Resource
    Pages: XXIII, 231 p. 38 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811544316
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    DDC: 571.978
    Language: English
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  • 2
    Keywords: Ecology . ; Water. ; Hydrology. ; Sustainability. ; Environmental management. ; Agriculture. ; Terrestial Ecology. ; Water. ; Sustainability. ; Environmental Management. ; Agriculture.
    Description / Table of Contents: Part I. Soils, Geographical and Climatic Features, Eco-Resources, and Desertification -- Chapter 1. Potential Threats to Soil Functions and Mitigation Options for Sustainable Uses -- Chapter 2. Perspectives of Geography, Environment, and Physiography of Kuwait -- Chapter 3. Climate and Climate Change Aspects of Kuwait -- Chapter 4. Ecological Footprint and Biocapacity of Kuwait and Proposed Eco-Resources Management Strategies – A Review -- Chapter 5. Desertification – A Central Problem to Restore Ecosystems -- Part II. Water Resources, Salinization Aspects and Modeling -- Chapter 6. Current Status, Challenges and Future Management Strategies for Water Resources of Kuwait -- Chapter 7. Groundwater Salinization in Kuwait: A Major Threat to Indigenous Ecosystems -- Chapter 8. Predicting the Behavior of the Salt/Fresh-Brackish Water Transition Zone During Scavenger Well Pumping: 1. Numerical Model Development and Testing -- Chapter 9. Predicting the Behavior of the Salt/Fresh-Brackish Water Transition Zone During Scavenger Well Pumping: 2. Model Application in Kuwait and Pakistan -- Part III. Terrestrial Ecosystems and their Management -- Chapter 10. Terrestrial Habitats and Ecosystems of Kuwait -- Chapter 11. Native Vegetation and Flora of Kuwait -- Chapter 12. Wildlife of the Terrestrial Ecosystems of Kuwait -- Chapter 13. Major Threats to the Terrestrial Ecosystems and Proposed Conservation Practices -- Chapter 14. Kuwait Deserts and Ecosystems in the Context of Changing Climate -- Part IV. Agriculture, Food Security and Water Footprint of Crops -- Chapter 15. Prospective of Agricultural Farming in Kuwait and Energy-Food-Water-Climate Nexus -- Chapter 16. Agricultural Water Footprint of Major Crops in Kuwait Compared to the World Average – A Review.
    Abstract: This book is an outcome of collaborative efforts of a multidisciplinary team of scientists. The core objective of this book is to provide cross-sectoral information on the different aspects of the terrestrial environment and ecosystems of Kuwait. The book will be considered as a ready source of information for those seeking information on the terrestrial environment and ecosystems, assessment and restoration, as well as sustainable uses and management. In spite of Kuwait’s hyper-arid environment, it is rich in natural resources including a wide range of native plants, animal species, different habitats, protected areas, diversified soils and water and oil resources. While the desert of Kuwait constitutes various features, such as sand sheet, sand dunes, nebkhas, inland and coastal sabkhas, rock outcrop, wadis and farming areas, it is rich in flora and fauna (native plants, mammals, birds, reptiles, etc.). Due to changing climate, deserts of Kuwait as well as other countries are under severe threat of degradation and the degradation may be irreversible. To realize these impacts, an effort is being made to provide a ready source of information to highlight the potential threats to the terrestrial ecosystems and formulate adaptation and mitigation strategies for long-term ecosystems services in Kuwait as well as other countries located in a desert environment, such as Gulf Cooperation Council Countries, Africa and countries in the Arab region. The book includes sixteen chapters covering multidiscipline subjects (such as natural resources, climate and climate change, geographical features, terrestrial habitats, ecosystems and threats, water and soil resources, agriculture, food security, water-energy-food-climate nexus, green-grey-blue water footprints of various crops, etc.). Thus, this book is a unique resource that provides the latest scientific information in a single volume.
    Type of Medium: Online Resource
    Pages: XXV, 420 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031462627
    DDC: 577
    Language: English
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  • 3
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Immunology. ; Medical microbiology. ; Molecular genetics. ; Stem cells. ; Cell death. ; Cancer Biology. ; Immunology. ; Medical Microbiology. ; Molecular Genetics. ; Stem Cell Biology. ; Cell Death.
    Description / Table of Contents: Chapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy – An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.
    Abstract: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
    Type of Medium: Online Resource
    Pages: VII, 280 p. 38 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811569302
    DDC: 571.978
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Oncology. ; Cancer Biology. ; Oncology.
    Description / Table of Contents: Role of specific phytochemicals against gastrointestinal malignancies -- Role of phytochemicals on growth and metastasis of GI cancer -- Cancer Stem Cells as Therapeutic Targets for Gastrointestinal cancers -- Phytochemicals plus checkpoint inhibitors in GI cancers -- Crucial role of curcumin on gut microbiota associated with GI cancers -- Cellular and Molecular mechanisms of garlic compounds in common GI cancers -- Combination of Phytochemicals with Nanotechnology for Targeting GI Cancer Therapy -- Emerging Roles of Phytochemicals in the Pathobiology and Management of Esophageal Cancer -- Gastric Cancer: Role of Phytochemicals and Tyrosine Kinase Inhibitors -- Therapeutic Efects Of Curcumin Against Colorectal Cancer -- Molecular Pathways Involved in the Pathogenesis of Pancreatic Cancer: Role of Phytochemicals in Targeting the Clinical Outcomes -- Role of Dietary Supplementation of Natural products in the Prevention and Treatment of Liver Diseases -- Emerging Roles of Phytochemicals in Hepatocellular Carcinoma -- Phytochemicals: Current Understandings of the Modern Therapeutic Approaches for Hepatocellular Carcinoma -- Index.
    Abstract: Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.
    Type of Medium: Online Resource
    Pages: XI, 340 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030484057
    DDC: 571.978
    Language: English
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  • 5
    Keywords: Ecology . ; Freshwater ecology. ; Marine ecology. ; Pollution. ; Biotic communities. ; Population biology. ; Ecology. ; Freshwater and Marine Ecology. ; Pollution. ; Community and Population Ecology. ; Ecosystems.
    Abstract: The book provides for the first time an overview of the latest scientific studies conducted on micro and nano plastic pollution in the Mediterranean Sea both from the biological and environmental point of view as well as from the chemical point of view in order to have a more real idea of the current situation.
    Type of Medium: Online Resource
    Pages: XII, 109 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031304811
    Series Statement: SpringerBriefs in Environmental Science,
    DDC: 577
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotic communities. ; Biogeography. ; Physical geography. ; Environmental policy. ; Landscape ecology. ; Biodiversity. ; Ecosystems. ; Biogeosciences. ; Physical Geography. ; Environmental Policy. ; Landscape Ecology. ; Biodiversity.
    Description / Table of Contents: Part I: Ecosystem Services Basics -- Chapter 1. Overview of the ecosystem services concept -- Part II: Ecosystem Services of Slovakia -- Chapter 2. Methodology of national ES assessment -- Chapter 3. Provisioning ecosystems services -- Chapter 4. Regulatory ecosystem services and supporting ecosystem functions -- Chapter 5. Cultural ecosystems services -- Part III: Synthesis -- Chapter 6. Synthesis of ecosystem services assessment in Slovakia.
    Abstract: This book provides the first comprehensive assessment of ecosystem services (ES) for the territory of the Slovak Republic. Although the ES approach is widely used for the evaluation of the benefits of natural capital and biodiversity for people, this book has a unique character. It provides an assessment of 18 individual ES, which are divided into three main groups - provisioning, regulatory/supporting and cultural ES. For each of ES, a brief theoretical and methodological overview is given, followed by spatial assessment based on own original methodology and dataset of 40 map layers. Besides, an evaluation of main ES groups and overall ES assessment is realized. This book emphasizes the key role of nature protection areas, large areas of forest ecosystems and mountain and sub-mountain areas, for the preservation of the various functions of the healthy landscape and ecosystems. The complexity of the book guarantees its usefulness - not only as the knowledge base for the territory of Slovakia but also as the methodological tool for worldwide researchers.
    Type of Medium: Online Resource
    Pages: XXVI, 244 p. 114 illus., 110 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030465087
    DDC: 577
    Language: English
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  • 7
    Keywords: Cancer. ; Medical genetics. ; Pharmaceutical chemistry. ; Bioinformatics. ; Cancer Biology. ; Medical Genetics. ; Pharmaceutics. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Phytochemicals in Cancer Chemoprevention: A Brief Perspective -- Chapter 2. Phytochemicals in Modulating Signalling Cascades in Cancer Cells -- Chapter 3. Diverse cancer therapeutic interactions: complexities in cancer management -- Chapter 4. Natural Products as Chemosensitizers for Adjunct Therapy in Cancer Management -- Chapter 5. Dietary phytochemicals as epigenetic modulators in cancer prevention: Emerging research trends, gaps, and future perspectives -- Chapter 6. Modulation of Cancer Cell Metabolism and Microenvironment by Phytochemicals -- Chapter 7. Role of Nutrigenetics and Nutrigenomics in Cancer Chemoprevention -- Chapter 8. Nano-delivery carriers for Enhanced Bioavailability of Antitumor Phytochemicals -- Chapter 9. Biphasic Effects of Phytochemicals and their Relevance to Cancer Therapeutics -- Chapter 10. Potential Pharmacotherapeutic Phytochemicals from Zingiberaceae for Cancer Prevention -- Chapter 11. 3 Dimensional Cell Culture Techniques in Cancer Research -- Chapter 12. Animal Models Systems of Cancer for Preclinical Trials -- Chapter 13. Cancer Chemoprevention by Natural Plant Products and Their Derivatives: Clinical Trials.
    Abstract: The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.
    Type of Medium: Online Resource
    Pages: XII, 337 p. 120 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811559990
    DDC: 571.978
    Language: English
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  • 8
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Metabolism. ; Cancer Treatment. ; Biochemistry. ; Oxidation-reduction reaction. ; Cancer Metabolism. ; Cancer Therapy. ; Redox Biology.
    Description / Table of Contents: 1. ROS, redox regulation and signaling in cancer cells -- 2. ROS and redox regulation/signaling and metabolism in cancer stem cells -- 3. . ROS/Redox regulation with dietary phytochemicals and role in anticancer activity -- 4. ROS/Redox signaling and apoptosis/necroptosis/autophagy in cancer -- 5. Cancer Metastasis, ROS/redox signaling and PCD resistance/redox metabolism -- 6. Immune system, redox signaling and cancer immunity -- 7. P53, ROS- redox regulation signaling, metabolic reprogramming and autophagy in cancer -- 8. Cell cycle, DNA damage-repair systems and impact of redox regulation in cancer -- 9. ROS, redox regulation and anticancer therapy -- 10. Perspectives in ROS/redox regulation cancer therapy.
    Abstract: This book aims to provide an association of the major redox-sensitive pathways and networks involved in cancer. The initial chapter of the book discusses basic information about oxidative stress, its generation, and regulation (redox regulation or redox homeostasis) via cell signaling in normal and cancer cells. The book also explores antioxidants and metabolic events in cancer cells compared to normal cells. It further covers the application of nanoparticles in redox regulation in cancer cells. The role of redox regulation in cancer therapy, its influence, and its involvement in programmed cell death (PCD), metastasis, immune system, p53, and cell cycle/DNA damage repair pathways have been discussed in separate chapters. It further reviews the importance of dietary phytochemicals in redox regulation in normal and cancer pathophysiology. Towards the end, the book focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells.
    Type of Medium: Online Resource
    Pages: XI, 431 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819973422
    DDC: 571.978
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Immunotherapy. ; Cancer Genetic aspects. ; Stem cells. ; Cancer Biology. ; Cancer Therapy. ; Tumour Immunology. ; Immunotherapy. ; Cancer Genetics and Genomics. ; Cancer Stem Cells.
    Description / Table of Contents: Interdisciplinary Approach in Hepatobiliary Cancers -- Liver Cancer: Interdisciplinary Approach -- The Immune System in Liver Cancer: From Beginning to Progression -- The Tumor Microenvironment in Hepatocellular Carcinoma -- Metabolic Alterations of Hepatocellular Cancer Stem Cells -- Τhe Role of Senescence in NASH-related HCC -- Regulators of Genetic Risk for the Progression of Non-alcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Reconstruction of Transcriptional Network and Signature-Based Metabolic Profiling -- Tumor Microenvironment and Immunotherapy in Advanced Biliary Tract Cancers -- Fibrosis and Immunotherapy in Hepatocellular Carcinoma -- Liver Cancer and the Curative Potential of Nanomedicine -- Locoregional Therapies for Hepatocellular Carcinoma -- Drug Resistance in Hepatocellular Carcinoma -- Liver Stereotactic Body Radiotherapy.
    Abstract: Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.
    Type of Medium: Online Resource
    Pages: XI, 365 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031445286
    Series Statement: Interdisciplinary Cancer Research, 3
    DDC: 571.978
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Cancer. ; Cancer Treatment. ; Oncology. ; Immunotherapy. ; Tumors Immunological aspects. ; Nanomedicine. ; Cancer Biology. ; Cancer Therapy. ; Oncology. ; Immunotherapy. ; Tumour Immunology. ; Cancer Nanotechnology.
    Description / Table of Contents: Interdisciplinary Approach in Gastrointestinal Cancers -- Gastrointestinal Cancers: What Is the Real Board of Microenvironment and the Role of Microbiota-Immunity Axis -- Epithelial-Mesenchymal Transition in Gastrointestinal Cancer: From a Basic to a Clinical Approach -- Metabolomics of Gastrointestinal Cancers -- Deregulation of Immune System in Gastric Cancer Development, How Immune Nutrition Might Restore the Functions of Immune Cells -- Helicobacter pylori Virulence Factors, Pathogenicity, and Gastric Cancer -- Gastric Cancer and Helicobacter pylori -- Role of Neuromodulators in Regulation of the Tumor Microenvironment of Gastric and Colorectal Cancers -- The Role of Tumor Microenvironment in Colon Cancer -- Unraveling the Esophageal Cancer Tumor Microenvironment: Insights and Novel Immunotherapeutic Strategies -- The Interplay Between Immunity and Gut Microbiota in Colon Cancer -- Immunotherapy in Gastrointestinal Cancer Focusing on CAR-T Cell Therapy -- Development of Biocompatible Nanocarriers for the Treatment of Colorectal Cancer -- Challenges of Onco-therapeutics in Early Onset Colorectal Cancer -- Unintentional Weight Loss and Malnutrition After Esophageal Cancer and Treatment -- Current Clinical Landscape of Immunotherapeutic Approaches in Pancreatic Cancer Treatment. The Tumor Microenvironment in Pancreatic Cancer and Challenges to Immunotherapy. .
    Abstract: Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.
    Type of Medium: Online Resource
    Pages: XI, 404 p. 22 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031483714
    Series Statement: Interdisciplinary Cancer Research, 4
    DDC: 571.978
    Language: English
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