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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Medical sciences. ; Drug development. ; Medicine Research. ; Biology Research. ; Pharmaceutical chemistry. ; Biometry. ; Toxicology. ; Pharmacology. ; Preclinical Research. ; Biomedical Research. ; Pharmaceutics. ; Biostatistics. ; Medical Toxicology.
    Description / Table of Contents: Introduction-.What is a DMC?-. Is a DMC required?-. Who is On the DMC?-. What are the Legal and Ethical Aspects of DMC?-. How does the DMC work with SDAC and Sponsor and External Groups ? -- What Does a DMC Meeting Look Like -- What data is used for DMC outputs and who programs? -- What is Included in DMC Outputs? -- What does the DMC final DMC outputs look like and how is it delivered? -- What Types of Safety Outputs Does the DMC Receive? -- What types of efficacy outputs does the DMC receive? -- What types of other outputs does the DMC receive? -- What About In-Between DMC Meetings -- What types of formal interim analyses does the DMC review? -- What does the paperwork from meetings look like? -- How does the DMC assess risk-benefit for their decision making? -- What are some examples? -- Conclusions.
    Abstract: This book provides an overview of Data Monitoring Committees - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotech/pharma and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity. This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to smoothly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the implications of it are so great. This book provides the following: Thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation; Includes practical and hands-on information on DMC implementation; Discusses a wide range of clinical trial – by phase and therapeutic area.
    Type of Medium: Online Resource
    Pages: XII, 111 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031287602
    DDC: 615
    Language: English
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  • 2
    Keywords: Pharmacology. ; Clinical medicine Research. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Clinical Research. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. Potentiality of Probiotics in Inactivation of Tetrodotoxin -- Chapter 2. Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics -- Chapter 3. Plant based Bioactive compounds in Cancer Therapeutics -- Chapter 4. Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics -- Chapter 5. Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immunobiological perspectives -- Chapter 6. The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery -- Chapter 7. The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study -- Chapter 8. Prebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives -- Chapter 9. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases. Chapter 10. Implications of probiotics and prebiotics on immune functions -- Chapter 11. Recent Trends in Natural Medicines and Nutraceuticals Research -- Chapter 12. Nutraceuticals-are alternative to modern medicines- Chapter 13. Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban -- Chapter 14. Drosophila melanogaster as an in-vivo model for the investigation of host microbiota interaction -- Chapter 15. Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development of Aquaculture.
    Abstract: The book titled ‘Prebiotics, Probiotics and Nutraceuticals’ is expected to direct many emerging research pathwaysneed at local and global levels for nutrition and food supplements for developing immunity for healthy life. This volume incorporates sixteen seminal papers on issue based research and their practical applications covering latest information and progress on different area of nutritional supplement research fight against disease. The book highlights the frontier issues and applications in nutritional biotechnology with wide coverage of the themes like Potentiality of Probiotics in Inactivation of Tetrodotoxin, Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics and Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development in Aquaculture.Plant based Bioactive compounds in Cancer Therapeutics, Recent Trends in Natural Medicines and Nutraceuticals Research, Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immune-biological perspectives, The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery, The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study andPrebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases, Implications of probiotics and prebiotics on immune functions. Recent Trends in Natural Medicines and Nutraceuticals Research, Nutraceuticals are alternative to modern medicines, Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban. This book will be very useful for the scholars, biotechnologists, agricultural scientists, nutritionist, medical doctors, researchers, teachers and students in the emerging field of biotechnology.
    Type of Medium: Online Resource
    Pages: XVI, 340 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811689901
    DDC: 615
    Language: English
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  • 3
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Medicine Research. ; Biology Research. ; Biomaterials. ; Pharmacy. ; Biomedical engineering. ; Pharmacology. ; Biomedical Research. ; Biomaterials. ; Pharmacy. ; Translational Research. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Chapter 1. Marine biopolymers for oral delivery of drug -- Chapter 2. Marine polymer based nanocarriers for drug delivery application -- Chapter 3. Alginate: A promising biopolymer in drug delivery system -- Chapter 4. Chitosan Based Nanocomposite as Targeted drug delivery Carrier -- Chapter 5. Marine Biopolymer Based Oral In situ Gel: Drug Delivery Applications -- Chapter 6. Marine biopolymers for transdermal drug delivery -- Chapter 7. Marine polysaccharides for skin drug delivery: hydrogels and microneedles solutions -- Chapter 8. Marine collagen: promising biomaterial in delivery of therapeutics for cancer therapy -- Chapter 9. Chitosan based gel for ocular drug delivery. Chapter 10. Marine based biopolymers for central nervous system drug delivery -- Chapter 11. Marine Biopolymers Based Anticancer Drug Delivery Systems -- Chapter 12. Marine-Derived polysaccharides: prospects for future pharmaceuticals and drug delivery systems.
    Abstract: This book is focused on marine based biomedical carriers for delivery of therapeutics. Marine biomaterials and bio-based carriers show wide applications in pharmaceutical as well as biomedical fields for delivery of small and large molecules. Biomaterial-based composites, scaffolds or matrix systems are promising systems for controlled and prolonged release of drug in target site and control the premature release of drugs or bioactive compounds. This book discusses the targeted delivery of drugs and therapeutic applications. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. The marine biomaterial-based systems are widely used for tissue engineering, and biomedical imaging. This book is meant for industry experts, students and researchers in the area of pharmaceutical sciences, biomedical engineering and material science and pharmacology.
    Type of Medium: Online Resource
    Pages: X, 453 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811647871
    DDC: 615
    Language: English
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  • 4
    Keywords: Pharmacology. ; Medicine Research. ; Biology Research. ; Medical genetics. ; Pharmacology. ; Biomedical Research. ; Medical Genetics.
    Description / Table of Contents: Chapter 1. Introduction and Principles of Pharmacogenomics and Precision medicine -- Chapter 2. Pharmacogenomics in Cardiovascular Diseases -- Chapter 3. Pharmacogenomics of Antitumor Chemotherapeutic Agents -- Chapter 4. Pharmacogenomics of Antitumor Targeted Agent and Immunotherapy -- Chapter 5. Pharmacogenomics of Immunosuppressant -- Chapter 6. Pharmacogenomics of Psychiatric drugs -- Chapter 7. Pharmacogenomics of Anti-Infective Agents -- Chapter 8. Pharmacogenomics of Antithrombotic drugs -- Chapter 9. Pharmacogenomics in Therapeutic Drug Monitoring -- Chapter 10. Pharmacomicrobiomics -- Chapter 11. Genotyping technology in Pharmacogenomics -- Chapter 12. The Ethical, Legal and Regulatory Issues Associated with Pharmacogenomics -- Chapter 13. Cost-effectiveness of pharmacogenetic-guided treatment -- Chapter 14. Application of pharmacogenomics in drug discovery and development -- Chapter 15. Barriers and Solutions in Clinical Implementation of Pharmacogenomics for Personalized Precision Medicine.
    Abstract: This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.
    Type of Medium: Online Resource
    Pages: VIII, 289 p. 33 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811538957
    DDC: 615
    Language: English
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  • 5
    Keywords: Pharmacology. ; Human physiology. ; Biotechnology. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Human Physiology. ; Biotechnology. ; Biomedical Research.
    Description / Table of Contents: The effect of curcumin supplementation on pulse wave velocity in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial -- Role of Curcumin in Regulating Long Noncoding RNA Expression in Cancer -- The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-blind, Randomized, Placebo-Controlled Trial -- Protective effects of curcumin phytosomes against high-fat diet-induced atherosclerosis -- Intravenous Curcumin Mitigates Atherosclerosis Progression in Cholesterol-fed Rabbits -- Updated review on the role of curcumin in gastrointestinal cancers -- Curcumin can bind and interact with CRP: an in silico study -- Antifungal activities of curcumin and difluorinated curcumin against clinical dermatophyte isolates -- Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial -- Effect of Curcumin on Severity of Functional Dyspepsia; a Triple Blinded Clinical Trial -- Possible mechanisms and special clinical considerations of curcumin supplementation in patients with COVID-19 -- Paving the road toward exploiting the therapeutic effects of ginsenosides: an emphasis on autophagy and endoplasmic reticulum stress -- Medicinal plants and phytochemicals regulating insulin resistance and glucose homeostasis in type 2 diabetic patients: A clinical review -- Plants with anti-addictive potential -- Use of Plant-Derived Natural Products in Sleep Disturbances -- The effects of nutraceuticals and herbal medicine on Candida albicans in oral candidiasis: a comprehensive review -- Pharmacological properties of the plant-derived natural products cannabinoids and implications for cardiovascular health -- Beneficial effects of plant-derived natural products on non-alcoholic fatty liver disease -- Crocin Improves Oxidative Stress in Testicular Tissues of Streptozotocin-Induced Diabetic Rats -- Beneficial Medicinal Plants for Memory and Cognitive Functions Based on Traditional Persian Medicine -- The use of medicinal plants for the treatment of alopecia in the Canon of Avicenna: an evidence-based review -- Ethnobotanical uses, phytochemistry and pharmacology of different Rheum species (Polygonaceae): A review -- Genus Rosa: A review of ethnobotany, phytochemistry and traditional aspects according to Islamic traditional medicine (ITM) -- Ethnobotany, Phytochemistry, traditional and modern uses of Actaea racemosa L. (Black cohosh): A review -- Ethnobotany, phytochemistry and pharmacological features of Centella asiatica: a comprehensive review -- Ethnomedicinal uses, phytochemistry and pharmacology of different Cichorium species (Asteraceae): A review -- Medicinal species of the genus Berberis: A review of their traditional and ethnomedicinal uses, phytochemistry and pharmacology -- Protective effects of intravenous magnesium sulfate in stroke patients receiving amiodarone: A randomized controlled trial -- In silico identification of novel interactions for FABP5 (Fatty Acid-Binding Protein 5) with nutraceuticals: Possible repurposing approach.
    Abstract: Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal of this contributed volume is to present a comprehensive collection on most important therapeutic aspects of plant-derived natural products and their molecular mechanisms of action.
    Type of Medium: Online Resource
    Pages: X, 603 p. 814 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030648725
    Series Statement: Advances in Experimental Medicine and Biology, 1308
    DDC: 615
    Language: English
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  • 6
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Medicine Research. ; Biology Research. ; Therapeutics. ; Pharmaceutical chemistry. ; Biomaterials. ; Pharmacology. ; Translational Research. ; Therapeutics. ; Pharmaceutics. ; Biomaterials.
    Description / Table of Contents: Chapter 1. Marine biomaterials: resources, categories and applications -- Chapter 2. Cross-linked marine biopolymers for delivery of therapeutics -- Chapter 3. Chitosan and Chitooligosaccharides: Preparation, Characteristics and their Potential Application as Therapeutic Agents -- Chapter 4. Marine collagen for delivery of therapeutics -- Chapter 5. Marine Biopolymers for delivery of Gene -- Chapter 6. Hydrogel scaffolds based on alginate, gelatin, and 2-hydroxyethyl methacrylate for tissue regeneration -- Chapter 7. Tissue Engineering application of marine based materials -- Chapter 8. Marine biopolymer for theranostic applications -- Chapter 9. Marine biomaterials as carrier of drugs/biomolecules for management of bone disorders -- Chapter 10. Expanding Role of Marine Natural Compounds in Immunomodulation: Challenges and Future Perspectives -- Chapter 11. Marine origin Bioactive Peptides: novel advances in the therapeutic potential.
    Abstract: This book provides updated information on marine-based biomedical carriers and their therapeutic potential. Marine biomaterials and bio-based carriers show wide application in pharmaceutical and biomedical fields to deliver small and large molecules. Biomaterial-based composites, scaffolds, or matrix systems are sound systems for controlled and prolonged drug release in target sites and control the premature release of drugs or bioactive compounds. This book discusses essential topics such as the therapeutic potential of marine collagen, management of bone disorders, gene delivery, natural marine compounds in immunomodulation, theranostic applications, tissue engineering, and regeneration. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. Marine biomaterial-based systems are popular for tissue engineering and biomedical imaging. This book is ideal for industry experts, students, and researchers in pharmaceutical sciences and pharmacology.
    Type of Medium: Online Resource
    Pages: X, 392 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811653742
    DDC: 615
    Language: English
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  • 7
    Keywords: Pharmacology. ; Medical care. ; Therapeutics. ; Neurology . ; Medicine Research. ; Biology Research. ; Pharmacology. ; Health Care. ; Therapeutics. ; Neurology. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. A Complete Patent Analysis of Cannabis/Marijuana in Drug Delivery and Disease Conditions -- Chapter 2. Neuropharmacological Approaches to Modulate Cannabinoid Neurotransmission -- Chapter 3. Cannabinoids in Cancer: Cross-talk Between Cannabinoids and miRNAs -- Chapter 4. Cannabis As A Potent Therapeutic Agent For Pharmaceutical Drugs: Recent Advancement In Drug Discovery And Human Healthcare -- Chapter 5. Cannabinoid-Based Innovative Prophylactic and Therapeutic Interventions for Neuropathic Pain and Migraine -- Chapter 6. The Legality of Use and Consumption of Cannabis (Marijuana) in the United States of America -- Chapter 7. Cannabis in Healthcare: Ethnobotanical and Pharmaceutical Perspectives and Legal Status in Turkey and The Middle East -- Chapter 8. Understanding the Pharmacokinetics, Safety Profile, and Scope of the Concerned Issue to Evade the Consumption of Cannabis/Marijuana -- Chapter 9. Traditional Uses of Cannabis in The Middle East and The Pathway to Cannabis-Based Healthcare in Israel -- Chapter 10. Traditional and Modern Health Uses of Cannabis sativa L. in Africa and its Phytochemical and Pharmacological Profile -- Chapter 11. Traditional Claims on Cannabis: An Indian and Global Scenario -- Chapter 12. Cannabis (Bhanga) in Classical Text of Ayurveda: An Evidence-Based Rationale -- Chapter 13. Cannabis-Based Cosmetic Products and Their Uses -- Chapter 14. Cannabis as A Unique and Valuable Nutraceutical Formulation for the Current and Future Global Wellbeing -- Chapter 15. Traditional, Cultural, and Nutraceutical Aspects of Cannabis in India.
    Abstract: The book contains review articles providing a comprehensive overview of cannabis/marijuana’s diverse healing aspects in human healthcare (medicinal, nutraceutical, skincare, etc.). The research articles include the role of cannabis in cancer treatment, drug discovery, cosmeceutical potential, prophylactic and therapeutic use for treating neuropathic pain and migraine, pharmacokinetics, safety profile, and issues related to the consumption of cannabis/marijuana.Another salient feature of the book is a complete mapping and region- and sector-wise critical analysis of cannabis/marijuana patents on healthcare and future directions for the benefit of researchers and businesses/entrepreneurs interested in the rapidly advancing area of cannabis. The text describes cannabis/marijuana’s detailed legal aspects, production prospects, and applications for healthcare and recreational purposes in the USA. It traces the traditional roots of cannabis use in Turkey, Israel, the Middle East, Africa, and India. This unique compendium of articles will be useful as a reference book for students, researchers, academics, business houses, and all individuals interested in medicinal, nutraceutical, cosmeceutical, traditional, legal, and commercial aspects of cannabis usage.
    Type of Medium: Online Resource
    Pages: XIX, 319 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811688225
    DDC: 615
    Language: English
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  • 8
    Keywords: Pharmacology. ; Invertebrates. ; Medicine Research. ; Biology Research. ; Epidemiology. ; Biochemistry. ; Pharmacology. ; Invertebrate Zoology. ; Biomedical Research. ; Epidemiology. ; Biochemistry.
    Description / Table of Contents: Chapter 1. Introduction: The snakebite problem -- Chapter 2. Evolution of snakes and systematics of Big Four venomous snakes of India -- Chapter 3. Snake venom: Composition, evolution, function, and biomedical applications -- Chapter 4. Indian spectacled cobra (Naja naja) -- Chapter 5. Indian common Krait (Bungarus cerelus) -- Chapter 6. Indian Russell’s viper (Daboia russelii) -- Chapter 7. Indian Saw-scaled viper (Echis carinatus) -- Chapter 8. Prevention and Treatment of Big Four Snakebite in India.
    Abstract: This book provides detailed and updated knowledge about medically important ‘Big Four’ venomous snakes of India (Indian spectacled cobra, Indian common krait, Indian Russell’s viper, and Indian saw-scaled viper). This book essentially covers the snakebite problem in the world with particular reference to Asia and India. It discusses the evolution and systematics of venomous snakes, emphasizing ‘Big Four’ venomous snakes of India; the evolution and composition of venoms determined by traditional biochemical and modern proteomic analyses. It also describes the pharmacological properties of enzymatic and non-enzymatic toxins of ‘Big Four’ venomous snakes of India. Different chapters discuss exciting topics such as species-specific and geographical differences in venom composition and its impact on pathophysiology and clinical manifestations of snakebite envenomation in India, biomedical application of Indian snake venom toxins; production and quality assessment of commercial antivenom, prevention, and treatment of snakebite in India, adverse effects of antivenom including strategies to combat antivenom reactions inpatient. This book caters to toxinologists, pharmacologists, zoologists, antivenom manufacturers, biochemists, clinicians, evolutionary biologists, herpetologists, and informed non-specialists interested to know about the Indian snake venoms. .
    Type of Medium: Online Resource
    Pages: XI, 161 p. 55 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811628962
    DDC: 615
    Language: English
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