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  • Books  (65)
  • Neurology.
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  • Books  (65)
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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Surgery. ; Neurology . ; Nervous system Radiography. ; Neuropsychology. ; Neurosurgery. ; Neurology. ; Neuroradiology. ; Neuropsychology.
    Description / Table of Contents: History of Epilepsy Surgery -- Epilepsy: Clinical, Epidemiological, and Therapeutical Aspects -- Presurgical Evaluation -- Surgical Tools and Techniques -- Anesthesia -- Temporal Lobe Resections -- Extratemporal Resections -- Hemispherical Procedures -- Long-Term Epilepsy-Associated Tumors (LEATs) -- MRI-Negative Epilepsies -- Pediatric Epilepsy Surgery -- Reoperations after failed surgery -- Pathology in Epilepsy Surgery -- Non-Resective Epilepsy Surgery -- Complications -- Cost-Effectiveness of Epilepsy Surgery -- The current Place of Epilepsy Surgery -- A personal view.
    Abstract: This book fills the gap between the increasing demand for epilepsy surgical experience and limited training facilities in this area. It comprehensively describes surgical techniques, including tricks and pitfalls, based on the author’s 30 years of experience, providing optimal and effective training for young neurosurgeons by avoiding learning by trial and error. Moreover, it also includes useful information for epileptologists and other professionals involved in the epilepsy surgical program to allow them to gain a better understanding of possibilities and limitations of epilepsy surgery. .
    Type of Medium: Online Resource
    Pages: XXI, 404 p. 154 illus., 111 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030487485
    DDC: 617.48
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Human physiology. ; Neurology . ; Life sciences. ; Physiology. ; Neuroscience. ; Human Physiology. ; Neurology. ; Life Sciences. ; Animal Physiology. ; Life Sciences.
    Description / Table of Contents: Part I: HISTORY -- Chapter 1: Transmissible Spongiform Encephalopathy: from its beginnings to Daniel Carleton Gajdusek -- Part II: GENERAL ASPECTS OF PRIONS -- Chapter 2: The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein -- Chapter 3: Mammalian Prion Structures -- Chapter 4: Insoluble Cellular Prion Protein and Other Neurodegeneration-related Misfolded Protein Aggregates in the Brain of Asymptomatic Individuals -- Part III: CONVERSION AND STRAIN OF PRIONS -- Chapter 5: Prion Conversion and Deformed Templating -- Chapter 6: Prion Strain Interference -- Chapter 7: Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins -- Chapter 8: Cofactor Involvement in Prion Propagation -- Chapter 9: Prion Protein Conversion and Lipids -- Part IV: ENVIRONMENT AND TRANSMISSION OF PRIONS -- Chapter 10: Prions in the Environment -- Chapter 11: Environmentally Acquired Transmissible Spongiform Encephalopathy -- Chapter 12: Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion -- Chapter 13: Species Barriers in Prion Disease -- Part V: MODELLING OF PRIONS -- Chapter 14: Modeling the Cell Biology of Prions -- Chapter 15: Transgenic Mice Modelling in Prion Diseases -- Chapter 16: Stem Cell Models in Prion Research -- Chapter 17: Drosophila Models of Prion Diseases -- Part VI: HUMAN PRION DISEASES AND OTHER PATHOLOGIES -- Chapter 18: Human Sporadic Prion Diseases -- Chapter 19 Genetic Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker Diseases -- Chapter 20: Glycoform-selective Prions in Sporadic and Inherited Variably Protease-sensitive Prionopathies -- Chapter 21: The Spectrum of Tau Pathology in Human Prion Disease -- Chapter 22: Prion Protein Complex with mGluR5 Mediates Amyloid-ß Synaptic Loss in Alzheimer’s Disease -- Chapter 23: Prion and Cancers -- Chapter 24: Protective Role of Cellular Prion Protein in Tissue Ischemic/Reperfusion Injury -- Part VII: ANIMAL PRION DISEASES -- Chapter 25: Bovine Spongiform Encephalopathy -- Chapter 26: Classical and Atypical Scrapie in Sheep and Goats -- Chapter 27: Research models for studying chronic wasting disease -- Part VIII: YEAST PRIONS -- Chapter 28: Introduction to Yeast and Fungal Prions -- Chapter 29: Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems -- Part IX: DIAGNOSIS AND HUMAN PRION SURVEILLANCE -- Chapter 30: Real-time quaking-induced conversion (QuIC) assays for the detection and diagnosis of human prion diseases -- Chapter 31: Protein Misfolding Cyclic Amplification -- Chapter 32: Skin Misfolded Proteins as Biomarkers for Diagnosis of Prion and Prion-like Diseases -- Chapter 33: Diagnosis of Prion Disease: Conventional Approaches -- Chapter 34: Human Prion Disease Surveillance -- Part X: TREATMENT -- Chapter 35: Overview on Treatment of Prion Diseases and Decontamination of Prions -- Chapter 36: Gene Therapy Strategies for Prophylactic and Therapeutic Treatments of Human Prion Diseases -- Chapter 37: Immunomodulation.
    Abstract: Transmissible spongiform encephalopathies (TSE), now known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains the most authoritative views about the past, present, and future of prions and prion diseases covering fresh perspectives on important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
    Type of Medium: Online Resource
    Pages: XII, 793 p. 81 illus., 62 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031205651
    DDC: 612.8
    Language: English
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  • 3
    Online Resource
    Online Resource
    Dordrecht :Springer Netherlands :
    Keywords: Neurology . ; Internal medicine. ; Psychiatry. ; Neurology. ; Internal Medicine. ; Psychiatry.
    Description / Table of Contents: Chapter 1. Evolving approaches to identifying genetic risk variants for sleep disorders -- Chapter 2. Neurobiology of sleep-wake control -- Chapter 3. Prostaglandins, adenosine and histaminergic system in the regulation of sleep and wakefulness -- Chapter 4.Sleep and Neuronal Plasticity -- Chapter 5. Epidemiology of Insufficient Sleep -- Chapter 6.Social Factors in Insufficient Sleep -- Chapter 7. Sleep Loss and the Unfolded Protein Response -- Chapter 8. Biological and genetic mechanisms of sleepiness in Obstructive Sleep Apnea and Cardiovascular Disease -- Chapter 9.Diaphragm EMG recording and its application in sleep medicine -- Chapter 10. Chronic Intermittent Hypoxia in Patients with OSA -- Chapter 11.Neural injury in models of intermittent hypoxia -- Chapter 12. Narcolepsy and Orexin/hypocretin -- Chapter 13.Circadian Rhythm Sleep-Wake Disorders: Mechanisms and Treatment.
    Abstract: The aim of this book is to provide health care professionals with an overview of the main aspects of recent advances in sleep medicine, with an emphasis on advancing basic science into clinical medicine. It is divided into three main parts. The first part is to cover the basic sleep mechanisms which includes genetics in sleep, and neural and humoral regulation of sleep and wakefulness. The second part focuses on the epidemiology of sleep, and the final part consists of the pathophysiological mechanisms of snoring and sleep apnea and other common sleep disorders as well as the consequences. The content of this book is written by experts and sleep specialists from all over the world and this book aims to optimize the health of individuals by “translating” bench side findings into clinical practice.
    Type of Medium: Online Resource
    Pages: VI, 282 p. 43 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789402421682
    Series Statement: Translational Medicine Research,
    DDC: 616.8
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neuropharmacology. ; Psychiatry. ; Neurology . ; Neuropharmacology. ; Psychiatry. ; Neurology.
    Description / Table of Contents: Dosing psychedelics and MDMA -- Psychedelic Group Therapy -- Set and Setting: Aesthetic experiences and their contribution to psychedelic therapies -- Psychedelic-Assisted Therapy for Social Adaptability in Autistic Adults -- Foundations for Training Psychedelic Therapists -- Ayahuasca for the Treatment of Depression -- Psilocybin for the Treatment of Depression -- Ketamine for the Treatment of Depression -- The Potential of Psychedelics for End of Life and Palliative Care -- Psychedelic-Assisted Therapy for Addiction and Potential Mechanisms of Action -- Psilocybin for Tobacco Use Disorder -- Psychedelic Drugs as Anti-Inflammatory Agents -- Psilocybin for the Treatment of Obsessive-Compulsive Disorder -- Psilocybin for the Treatment of Headache and Pain Disorders -- Psilocybin for the Treatment of Neurodegenerative Disorders -- Psilocybin for Trauma-Related Disorders.
    Abstract: Psychedelic therapies are gaining traction as potential treatments for a wide range of indications, but the structure and delivery of psychedelic therapies are a sharp departure from more traditional models of psychotherapy and pharmacotherapy for psychiatric and other medical disorders. This may be critical to their success. The current volume provides a comprehensive review of the state of the science of psychedelic therapies, including discussion of models and approaches to psychedelic therapies as well as the current status of safety and efficacy data for mood, substance use, trauma, obsessive-compulsive, neurodevelopmental, neurodegenerative disorders, neurological, and inflammatory disorders.
    Type of Medium: Online Resource
    Pages: VIII, 332 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031121845
    Series Statement: Current Topics in Behavioral Neurosciences, 56
    DDC: 615.78
    Language: English
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  • 5
    Keywords: Neurosciences. ; Pain medicine. ; Neurology . ; Anesthesiology. ; Neuroscience. ; Pain Medicine. ; Neurology. ; Anesthesiology.
    Description / Table of Contents: Introduction to Acute, Chronic, and Episodic Pain -- Inflammation and Pain -- Animal Models of Pain and Anti-inflammatory Treatments -- Inflammatory Mediators, Nociceptors, and Their Interactions in Pain -- Immune and Glial Cells in Pain and Their Interactions with Nociceptive Neurons -- Sex Differences in Neuroimmune Interactions and Pain -- Neuroimmune Interactions in Itch -- Toll-like Receptors in Pain and Itch -- Immunotherapy and Pain -- Cell Therapy and Regenerative Pain Medicine - Preclinical Studies -- Cell-based Therapies in Pain Management -- Platelet-Rich Plasma and Autologous Conditioned Serum: Non-Cellular Biologic Therapies for Neuroimmune Modulation and the Treatment of Arthritis Pain -- Exercise and Diet in the Control of Inflammation and Pain -- Mechanism-Based Pain Therapies -- Neuromodulation in Pain Management -- What Patients Need to Know about Pain Therapy?.
    Abstract: As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.
    Type of Medium: Online Resource
    Pages: X, 364 p. 45 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031292316
    DDC: 612.8
    Language: English
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  • 6
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Neurosciences. ; Neurology . ; Evolution (Biology). ; Psychobiology. ; Human behavior. ; Neuroscience. ; Neurology. ; Evolutionary Biology. ; Behavioral Neuroscience.
    Description / Table of Contents: Sleep: Basic and Historical Aspects -- Sleep: Findings in Invertebrates and Lower Vertebrates -- Sleep: Evolutionary and Adaptive Changes in Birds and Mammals -- Sleep Loss: What Does it do to our Brain and Body -- Sleep: Neural Optimization as An Ultimate Function for Memory Consolidation -- Sleep: Disorders and Clinical Implications.
    Abstract: This book discusses the evolution of sleep and its possible function in the higher invertebrates and vertebrates, including humans. It describes the current concept of sleep and its functions, based on research on the mammalian system. To date, electrophysiological recordings of the brain waves, muscle activity, and eye movements are the only tools available for characterizing the sleep architecture in the majority of animals. In mammals and birds, only two distinct types of sleep are found – non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Since the discovery of REM sleep, studies have been performed to understand the purpose of the two distinct sleep states in higher vertebrates (birds and mammals), and how REM sleep was evolved. The book summarizes the role of both REM and NREM sleep in the proper functioning of the brain and body. It covers various aspects of the role of sleep in important physiological processes, including memory consolidation, induction of synaptic plasticity, energy restoration, enhancing immune response, and maturation of neuronal circuitries during early life. Lastly, the book reviews the effects of chronic/acute sleep deprivation on memory consolidation, obesity, and the immune system in animal models and humans.
    Type of Medium: Online Resource
    Pages: XIV, 118 p. 30 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811571756
    DDC: 612.8
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Surgery. ; Blood-vessels Surgery. ; Neurology . ; Neurosurgery. ; Vascular Surgery. ; Neurology.
    Description / Table of Contents: Brief History of Cavernous Malformations -- Definition and structure of cerebral cavernous malformations -- Molecular Biology of CCM -- Presentation -- Neuroimaging of Cerebral Cavernous Malformations -- Natural history of cavernous malformations -- Hemispherical Cavernomas in non-eloquent and eloquent areas -- Cavernoma-Related Epilepsy -- Surgery of deep-seated cavernous malformations -- Surgery of brainstem and cerebellar cavernous malformations -- Stereotactic Radiosurgery of Cavernous Malformations -- Cavernomas in children -- Cavernomas During Pregnancy -- Spinal cavernous malformations -- Intraorbital cavernous malformations.
    Abstract: This book presents a complete up-to date description of cavernoma disease together with its known biology, genetics and variable clinical presentation. It facilitates improved decision-making on surgical intervention by presenting different cases, highlighting the particular features of lesions such as anatomical location, eloquences of adjacent brain and type of presentation that are important when making decisions. In addition, the reader is brought up to speed with developments in the neuroimaging and active treatment techniques, especially surgical resection and radiosurgery. Finally, the natural history of the disease is taken into account and compared to the possible benefits of surgical treatment. Cavernomas of the CNS: Basic Science to Clinical Practice provides a comprehensive overview from the fundamentals of this condition, to special patient groups such as children and pregnant women. Therefore, it is an indispensable resource for neurovascular surgeons, neurosurgical residents and neurologists.
    Type of Medium: Online Resource
    Pages: VIII, 245 p. 124 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030494063
    DDC: 617.48
    Language: English
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  • 8
    Keywords: Nervous system Surgery. ; Neuropsychology. ; Neurology . ; Neurosurgery. ; Neuropsychology. ; Neurology.
    Description / Table of Contents: Foreword -- Preface -- Part I: Sensorimotor and visuo-spatial functions -- 1. Motor control -- 2. Vision -- 3. FEF -- 4. Spatial cognition -- Part II: Language functions -- 5. Lexical access -- 6. Spontaneous speech -- 7. Reading -- 8. Writing -- 9. Repeating -- 10. Syntactic abilities -- 11. Verbs versus nouns naming -- 12. Verbal short-term memory -- 13. Proper names retrieval -- 14. Bilingual patients -- Part III: Higher-order functions -- 15. From verbal to non-verbal semantics -- 16. Inhibition -- 17. Set-shifting -- 18. Social cognition -- 19. Multitask mapping -- Part IV: Prospects -- 20. Creativity -- 21. Psychiatric and behavorial traits -- 22. Awake surgery in patients with poor abilities of verbal communication -- 23. Can we map inner speech? -- 24. Beyond tasks: when experience shapes intuition.
    Abstract: This book aims to give the state-of-the-art of intraoperative brain function mapping for resection of brain tumors in awake conditions, and to become a reference for acquiring the fundamental expertise necessary to select the right intraoperative task at the right time of the surgery. The chapters, all focused on a specific brain function, are divided in 4 parts: sensori-motor and visuo-spatial functions, language functions, higher-order functions, and prospects. Each chapter follows the same outline, including a brief review of the current knowledge about the networks sustaining the function in healthy subjects, the description of the intraoperative tasks designed to monitor the function, a review of the literature describing the deficits in that function after surgery, and a critical appraisal of the benefit provided by intraoperative mapping of that function.
    Type of Medium: Online Resource
    Pages: XIV, 421 p. 93 illus., 90 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030750718
    DDC: 617.48
    Language: English
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  • 9
    Keywords: Neurosciences. ; Neurology . ; Pharmacology. ; Neuroscience. ; Neurology. ; Pharmacology.
    Description / Table of Contents: Chapter 1: Why study Drug Resistant Epilepsy? -- Chapter 2: Pharmacoresistance in Epilepsy -- Chapter 3: Experimental models for the study of drug-resistant epilepsy -- Chapter 4: On Complexity and Emergence: Linking the Hypotheses of Pharmacoresistance in Epilepsy -- Chapter 5: Role of High-Frequency Oscillation Networks in Managing Pharmacoresistant Epilepsy -- Chapter 6: Transporter hypothesis in pharmacoresistant epilepsies. Is it at the central or peripheral level? -- Chapter 7: Changes in Targets as an Explanation for Drug Resistance in Epilepsy -- Chapter 8: Cellular and molecular mechanisms of neuroinflammation in drug-resistant epilepsy -- Chapter 9: Contribution of the antiepileptic drug administration regime to avoid the development and/or establishment of pharmacoresistant epilepsy -- Chapter 10: Pharmacogenetics in Epilepsy and Refractory Epilepsy -- Chapter 11: Seizures Induce Hypoxia or Hypoxia Induces Seizures. A Perverse Relationship that Increases the Risk of SUDEP -- Chapter 12: Neonatal excitotoxicity triggers degenerative processes related to seizure susceptibility and pharmacoresistance -- Chapter 13: Cerebrovascular remodeling and the role of vascular endothelial growth factor in the epileptic brain and pharmacoresistance -- Chapter 14: The Role of JNK3 in Epilepsy and Neurodegeneration -- Chapter 15: Application of proteomics in the study of molecular markers in epilepsy -- Chapter 16: GABAergic neurotransmission abnormalities in pharmacoresistant epilepsy: experimental and human studies -- Chapter 17: Genes involved in pharmacoresistant epilepsy -- Chapter 18: Drug-resistant Epilepsy and the Influence of Age, Gender and Comorbid Disorders -- Chapter 19: Indications for Intracerebral Recording in Candidates for Epilepsy Surgery -- Chapter 20: On the Development of New Drugs for the Treatment of Drug Resistant Epilepsy: An Update on Different Approaches to Different Hypotheses -- Chapter 21: Physical exercise as a strategy to reduce seizure susceptibility -- Chapter 22: Ketogenic Diet and Drug-resistant Epilepsy -- Chapter 23: Modulating P-glycoprotein Regulation as a Therapeutic Strategy for Pharmacoresistant Epilepsy -- Chapter 24: Vagus Nerve Stimulation for Intractable Seizures -- Chapter 25: Non Invasive Brain Stimulation as a potential Therapeutic Procedure in drug-resistant epilepsy -- Chapter 26: Effects of transcranial focal electrical stimulation via concentric ring electrodes on seizure activity.
    Abstract: This new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as well in experimental models and presents the basis for an understanding of recent developments in the pathogenesis and treatment of this condition. Important issues associated with drug-resistant epilepsy are reviewed and updated, such as abnormalities in inhibitory mechanisms, neurotoxicity and changes the immune system associated with this disorder, and the development of drug-resistance as consequence of chronic exposure to antiseizure-medications. Considering that a major obstacle is that epilepsy associated with drug-resistance cannot be controlled with the traditional antiseizure medications, specific chapters describe therapeutic strategies to prevent or reduce the progression of the disease with complementary medical therapies, such as transcranial focal stimulation to promote neuroprotection. Pharmacoresistance in Epilepsy is a valuable resource for anyone working in the field, whether studying epilepsy in the lab or treating it in an office.
    Type of Medium: Online Resource
    Pages: XV, 596 p. 84 illus., 79 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031365263
    DDC: 612.8
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neurology . ; Developmental neurobiology. ; Neuroscience. ; Neurology. ; Development of the Nervous System.
    Description / Table of Contents: The development of the cerebellum: from the beginnings -- Part I: Responsibilities and liabilities -- Chapter2. The embryology and anatomy of the cerebellum -- Chapter 3. Cellular and genetic programs underlying cerebellum development -- Chapter 4. Early Purkinje Cell Development and the Origins of Cerebellar Patterning. - Chapter 5. Development of the Fish Cerebellum. -Chapter 6. Cerebellar developmental disorders and cerebellar nuclei -- Chapter 7. Motor circuit abnormalities during cerebellar development -- Chapter8. Developmental disorders of the cerebellum and neurotrophic factors -- Chapter9. Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development -- Chapter10. The ubiquitin proteasome system and cerebellar developmental disease -- Chapter11. Epigenetics and Cerebellar Neurodevelopmental Disorders -- Chapter12.. Hormonal regulation of cerebellar development and its disorders -- Chapter13. Infections of the Cerebellum -- Chapter14. Neuroimmune mechanisms of cerebellar development and its developmental disorders -- Chapter15. Teratogenic influences on cerebellar development -- Chapter16. Primary pediatric brain tumors of the posterior fossa -- Chapter17. Primary pediatric brain tumors of the posterior fossa -- Chapter18. Can cerebellar neurodevelopmental disorders affect behavioral disorders or vice versa -- Chapter19. Neurodevelopmental disorders of the cerebellum: autism spectrum disorder -- Chapter20. Congenital cerebellar disease -- Chapter21. Clinical features, assessment, and management of patients with developmental and other cerebellar disorders -- Chapter22. Epidemiology of cerebellar disorders -- Chapter23. Cerebellar transplantation: a potential model to study repair and development of neurons and circuits in the cerebellum. - Chapter 24. Non-coding RNAs and cerebellar development. - Chapter 25. Defining the Cerebellar Cytoarchitecture Using MRI. .
    Abstract: This updated reference covers diverse aspects of cerebellar development from a full range of viewpoints, including the epidemiology of cerebellar genetic disorders, developmental anatomy, cell biology, genetics, epigenetics, infectious diseases, and mechanisms involved in the regulation of cell fate, while also focusing on information that is relevant to clinicians caring for patients with cerebellar disorders. The chapters are written by experts in the field of cerebellar development, and the chapters cover diseases related to the cerebellum, along with their epidemiology, clinical features, assessment, and management. In addition to updating the content to cover the significant developments in the field since the first edition, the second edition will include new chapters on Non-Coding RNAs and Cerebellar Development, Development of the Fish Cerebellum, the Role of nNOS/NO on Cerebellar Development in Health and Disease, and rehabilitation in cerebellar ataxia. The effect of the COVID-19 on the cerebellum has been included in related chapters. Development of the Cerebellum from Molecular Aspects to Diseases, 2nd edition, is designed to be valuable reference for both neuroscientists and clinicians.
    Type of Medium: Online Resource
    Pages: IX, 639 p. 116 illus., 88 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031231049
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 11
    Keywords: Neurosciences. ; Neurology . ; Neuroscience. ; Neurology.
    Description / Table of Contents: PART 1: WAKEFULNESS -- Chapter 1. Exploring Oscillations in Expert Sensorimotor Anticipation: the Tennis Return of Serve -- Chapter 2. Theta Rhythm in Hippocampus and Cognition -- Chapter 3. Oscillations and Synchrony in Attention -- Christian Keitel, Gregor Thut, and Joachim Gross -- Chapter 4. Pathological High-Frequency Oscillations in Mesial Temporal Lobe Epilepsy -- PART TWO: SLEEP -- Chapter 5. Cellular Mechanisms of Thalamocortical Oscillations in the Sleeping Brain -- Chapter 6. Neuroimaging of Brain Oscillations During Human Sleep -- Chapter 7. A Role for Neuronal Oscillations of Sleep in Memory and Cognition -- Chapter 8. Sleep Oscillations and Aging -- Chapter 9. Sleep Oscillations and Psychiatric Disorders.
    Abstract: This edited volume reviews recent findings that highlight the mechanisms and functions of the neuronal oscillations that structure brain activity across the sleep-wake cycle. An increasing number of studies conducted in humans and animals use a variety of techniques, ranging from intracellular recording to functional neuroimaging, that provide important insight into the mechanisms and functional properties of these brain rhythms. This book explores how the studies of these rhythms are fundamental not only for basic neuroscience, but also for clinical neuroscience. At the basic science level, neuronal oscillations shape the interactions between different areas of the brain and profoundly impact neural responses to the environment, thereby mediating the processing of information in the brain. At the clinical level, brain oscillations are affected in numerous neurological conditions and might provide useful biomarkers that inform about patients’ evolution and vulnerability. During sleep, these brain rhythms could provide functional support to internal states that govern the basic maintenance of local circuit and systemic interactions. During wake, the rhythmicity of cortical and subcortical circuits have been linked with sensory processing, cognitive operations, and preparation for action.This volume attempts to link together these sleep and wake functional roles at the level of neuroimaging and electroencephalographic measures, local field potentials, and even at the cellular level. .
    Type of Medium: Online Resource
    Pages: XXI, 277 p. 40 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9781071606537
    DDC: 612.8
    Language: English
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  • 12
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Neurosciences. ; Medical care. ; Neurology . ; Biomedical engineering. ; Biotechnology. ; Neuroscience. ; Health Care. ; Neurology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Chapter 1: Application of reinforcement and deep learning techniques in brain machine interfaces -- Chapter 2: Specific muscle activation patterns in athletic and orthopedic populations: considerations for using surface electromyography in assistive and biofeedback device applications -- Chapter 3: Kineto-dynamic modeling of human upper limb for robotic manipulators and assistive applications -- Chapter 4: Learning from the human hand: force control and perception using a soft-synergy prosthetic hand and non-invasive haptic feedback -- Chapter 5: Design of a soft glove-based robotic hand exoskeleton with embedded synergies -- Chapter 6: Model predictive control based knee actuator allocation during a standing-up motion with a powered exoskeleton and functional electrical stimulation -- Chapter 7: Deep brain stimulation for gait and postural disturbances in Parkinson’s disease -- Chapter 8: Cognitive and physiological intent for the adaptation of motor prostheses -- Index.
    Abstract: This book provides a comprehensive review of recent developments in the field of motor neuroprosthetics and brain-machine interfaces. Chapters in this book are provided by leading experts in the field and include topics such as the design and control of multidimensional prosthetics and exoskeletons, deep brain stimulation, functional electrical stimulation, deep learning for brain machine interfaces, biofeedback, and cognitive intent for adaptation of motor prostheses. This book is a great resource for undergraduate and graduate students, researchers, engineers from related disciplines, entrepreneurs, and anyone interested in the latest progress in the field of motor neuroprostheses.
    Type of Medium: Online Resource
    Pages: XII, 162 p. 57 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030387402
    DDC: 660.6
    Language: English
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  • 13
    Keywords: Medical sciences. ; Neurology . ; Orthopedics. ; Pediatrics. ; Health Sciences. ; Neurology. ; Orthopaedics. ; Pediatrics.
    Description / Table of Contents: Chapter 1) Introduction -- Chapter 2) History of Neurosurgical Treatment for Spasticity -- Chapter 3) Anatomical Bases of Tone and Spasticity -- Chapter 4) Assessment of Spasticity in Adults -- Chapter 5) Decision-Making for Adults with Disabling Spasticity -- Chapter 6) Intrathecal Baclofen Therapy -- Chapter 7) Botulinum Toxin Injections for Spasticity -- Chapter 8) Peripheral Neurotomy -- Chapter 9) Surgery in the Dorsal Root Entry Zone -- Chapter 10) Spasticity and Hypertonia in Cerebral Palsy: Mechanisms and Surgical Implications -- Chapter 11) Assessment of Spasticity in Pediatric Patients -- Chapter 12) Decision-Making for Neurosurgical Treatment in Children with Disabling Spasticity -- Chapter 13) Dorsal Rhizotomy for Children with Cerebral Palsy -- Chapter 14) Neuro-Orthopedic Surgery for Correction of Spastic Disorders -- Chapter 15) Management of Neurogenic Overactive Bladder -- Chapter 16) Brief on Decision-Making for Neurosurgery of Spasticity in Adults and Children -- Chapter 17) Scales and Forms to Be Used in Practice.
    Abstract: The book, in its second edition, is devoted to the neurosurgical management of spasticity and focal dystonia. Starting with a chapter on the anatomical and physiological bases of spasticity and a short history of its neurosurgical treatment, it describes the neurosurgical methods currently available. As management differs between adults and children, the book is also structured accordingly, including evaluation, decision-making, Intrathecal Baclofen therapy (ITB), Botulinum toxin therapy and Surgery. The large spectrum of scales for assessing hypertonia, spasticity, dystonia, contracture and joint/bone deformities, as well as the scoring systems for quantifying functional abilities are critically reviewed. Beyond ITB, the neurosurgical options covered include the microsurgical procedures focusing on the peripheral nerves, dorsal roots, Dorsal Root Entry Zone and spinal cord, and their intra-operative monitoring. In this second edition, the orthopedic surgical interventions available will take a large place, either as alternative solutions , or even better as important complements after spasticity be solved by the neurosurgical treatments. Based on surgical experience collected with more than a thousand and eight-hundred patients, the book gathers the most important aspects of our present understanding, presented using a practical, educational approach. It stresses the importance of a multidisciplinary approach, including neurologists, pediatricians and rehabilitation specialists. Close collaborations with other surgical disciplines like orthopedic surgery and neuro-urology are outlined.
    Type of Medium: Online Resource
    Pages: XV, 359 p. 179 illus., 110 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030927172
    DDC: 610
    Language: English
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  • 14
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Surgery. ; Oncology. ; Radiology. ; Neurology . ; Neurosurgery. ; Oncology. ; Radiology. ; Neurology.
    Description / Table of Contents: Meningiomas: Overview -- Histopathology and Grading of Meningiomas -- Radiology -- The Genomic Landscape of Meningiomas -- The Initial Evaluation and Surveillance of Meningiomas -- Surgical Considerations for Newly Diagnosed Meningiomas -- Endoscopic and Minimally Invasive Meningioma Surgery -- Spinal Meningioma: Comprehensive Strategies for Management -- Radiation Therapy for the Management of Benign Meningioma -- Benign Tumor Recurrence and Management of More Aggressive Meningiomas -- Surgical Considerations for Recurrent Meningiomas -- Radiotherapy for Aggressive Meningiomas and Recurrent WHO Grade I Meningiomas -- The Role of Medical Therapy -- Emerging Therapies I: Precision Medicine, Targeted Therapies, and Mutation-Specific Approaches -- Emerging Therapies II: Immunotherapies, Novel Radiotherapy Techniques and Other Experimental Approaches.
    Abstract: This book provides a comprehensive overview of the multidisciplinary management of meningiomas, followed by evaluation and management considerations along a spectrum of benign to more malignant behavior. It outlines the management of presumed Grade 1 tumors and how to identify features of tumors radiographically and clinically that may support a benign course rather than aggressive and vice versa. Following a stepwise progression from simple to complex, chapters introduce and tackle more aggressive meningiomas and tumor recurrence (of all Grades), with paradigms for evaluation and treatment. Tumor biology and genomics are fundamental and largely focused in the book. More recent findings which have directed personalized medicine and clinical trials are also addressed. Meningiomas: Comprehensive Strategies for Management addresses all aspects of the evaluation and care of patients with all WHO grades of meningiomas. It is highly informative and provides clarity for a wide audience of neurosurgeons, reconstructive surgeons, oncologists, neurologists, radiation oncologists, pathologists, radiologists, residents and students who treat these patients and those who are training for a career in managing patients with these potentially challenging tumors.
    Type of Medium: Online Resource
    Pages: XIII, 243 p. 46 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030595586
    DDC: 617.48
    Language: English
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  • 15
    Keywords: Nervous system Surgery. ; Radiology. ; Biophysics. ; Nervous system Radiography. ; Neurology . ; Neurosciences. ; Neurosurgery. ; Radiology. ; Biophysics. ; Neuroradiology. ; Neurology. ; Neuroscience.
    Description / Table of Contents: Foreword -- Preface -- Introduction -- 1. Physics and radiation dosage issues in neuroradiosurgical treatment of meningiomas -- 2. Imaging Approaches for radiosurgical treatment of Meningiomas -- 3. MEDICAL MANAGEMENT OF MENINGIOMAS -- 4. Systemic Treatments for Grade II and III Meningiomas (WHO) -- 5. Gamma Knife Radiosurgery for Posterior Cranial Fossa Meningioma -- 6. Stereotactic Radiosurgery for Cavernous Sinus Meningiomas -- 7. Hypofractionated radiosurgery for perioptic meningiomas: Current practice, principles and treatment quandary -- 8. Hypofractionation and normofractionation in Skull Base Meningiomas -- 9. Atypical and anaplastic meningiomas: is there a role for stereotactic radiosurgery? -- 10. CyberKnife Treatment of Atypical Meningiomas (GII) -- 11. SRS & Microsurgery: antagonistic or complementary in the treatment of meningiomas? -- 12. Combined microsurgical and radiosurgical treatment in intracranial meningiomas -- 13. SRS in Incidental Meningioma: Whether to Treat and When -- 14. Side-effects of SRS treatment of low-grade meningioma: types, frequency and management -- 15. Single- and Multiple-Session Radiosurgery for Spinal Meningioma: Radiosurgery for spinal meningioma -- 16. Guidelines and evidence-based recommendations for the radiosurgical treatment of CNS meningiomas.
    Abstract: Meningiomas are the most frequently reported neuro-oncologic condition, accounting for 12% to 30% of all primary intracranial tumors. The first case of intracranial meningioma treated with stereotactic radiosurgery was reported by Backlund E-O in 1971. Since then, more than 200,000 meningiomas have been treated with stereotactic radiosurgery worldwide to date. The large number of patients treated using this method is due to the fact that meningiomas are frequently located in critical areas and microsurgery is often associated with severe and permanent neurological complications. This book discusses the advantages, risks and limits of stereotactic radiosurgery relating to all regions of interest for a neuroradiosurgical approach for the treatment of central nervous system meningiomas. Firstly, it presents an introduction focusing on the “state of the art”. It then discusses the physics, imaging, neurological and neuro-oncological issues in multidisciplinary management. Lastly, it features a summary of results, including the most recent published papers regarding all the locations involved in the stereotactic radiosurgery treatment as well as new approaches to meningiomas, with particular reference to the hypofrationated treatments. Intended for anyone involved in the neuroradiosurgical treatment of brain diseases, the book provides an up-to-date overview of the latest stereotactic radiosurgery treatment of central nervous system meningiomas.
    Type of Medium: Online Resource
    Pages: X, 160 p. 30 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030794194
    DDC: 617.48
    Language: English
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  • 16
    Keywords: Nervous system Surgery. ; Neurology . ; Radiology. ; Neurosurgery. ; Neurology. ; Radiology.
    Description / Table of Contents: Evidence on Mechanical Thrombectomy in Acute Ischemic Stroke -- In Vitro Clot Modeling and Clinical Applications -- Approaches to Mechanical Thrombectomy in Children with Arterial Ischemic Stroke -- ELVO in Urban Areas: Evolution of Stroke Systems of Care -- Surviving Large Vessel Occlusions in Uruguay: Current Challenges and Solutions -- Direct to Angiography—An Emerging Paradigm in Large Vessel Occlusion Stroke: Rationale, Feasibility, and Preliminary Results -- Thrombectomy Techniques: Stent Retriever - Balloon Guide -- Direct Aspiration thrombectomy for acute stroke: Evolution of technique and evidence -- The Stentriever-Mediated Aspiration Thrombectomy (SMAT) Technique -- Transradial Approach for Stroke -- Thrombectomy Techniques: Remote Aspiration -- Endovascular Therapy for Middle Cerebral Artery Occlusions -- Thrombectomy for Basilar Occlusion: Approach and Strategy -- Carotid Terminus Occlusion -- Thrombectomy for Acute Occlusion in Intermediate-Sized Distal Arteries -- The Tandem Occlusion -- Acute Stroke Thrombectomy and Emergent Management of Tandem Cervical Dissections -- Acute Stroke Following Carotid Endarterectomy: Approach and Strategy -- Large vessel occlusion with underlying atherosclerosis: approach and strategy -- Large Vessel Occlusion with Low NIHSS: Approach and Strategy -- Challenges in Thrombectomy: Mega Clots -- Challenges in thrombectomy: Access Problems, Hard Clots, Relapsing Occlusions and Embolizaton to New Territories -- Challenges in Thrombectomy: Impossible Aortic Arches and Tortuous Vessels.
    Abstract: This comprehensive, case-based resource provides the state-of-the-art knowledge that can help readers improve access and optimize delivery of stroke thrombectomy. Improving access to stroke is of particular importance because patients often misinterpret their symptoms or cannot speak for themselves if they have aphasia. More importantly, access needs to be organized because stroke therapies are all extremely time-sensitive. Scalable, choreographed protocols are necessary for emergency medical systems to ‘capture’ stroke patients and automatically transport and triage to time-sensitive treatments. Many of the chapters in the first section on Fundamentals and Systems provide valuable insight in improving access to stroke care. Replete with illustrative case studies and emphasizing that treatment approaches to stroke should not be comprised of a one-size-fits-all approach, this illuminating title provides the complete thought, detail, insight and organization that will help readers meet the needs of stroke patients with large vessel occlusions. 12 Strokes: A Case-based Guide to Acute Ischemic Stroke Management examines the primary technical principles that underlie the current thrombectomy approaches. Instead of continuing the conceptual dichotomy of stent vs. aspiration, many of the chapters look at underlying principles and then discuss ways in which the currently available devices and approaches can best exploit them. The variety, creativity and detail in many of these chapters will help the reader develop a deeper understanding that might assist their ability to successfully take care of their next patient that ‘doesn’t follow the textbook.’ In addition, the anatomic and pathophysiologic classification of the core Twelve Chapters will help readers organize their thinking and approach. This knowledge, particularly because it is organized based on common, challenging syndromes, will arm the reader to quickly recognize patterns and deftly adapt their management approaches to the needs of the patient. An invaluable contribution to the clinical literature, 12 Strokes: A Case-based Guide to Acute Ischemic Stroke Management will be of great interest to not only neurosurgeons and neurologists but other specialists, primary care providers, and trainees as well. .
    Type of Medium: Online Resource
    Pages: XVII, 337 p. 115 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030568573
    DDC: 617.48
    Language: English
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  • 17
    Keywords: Neurosciences. ; Neurology . ; Medical genetics. ; Neuroscience. ; Neurology. ; Medical Genetics.
    Description / Table of Contents: 1. Behavioural variant FTD: recent advances in the diagnosis and understanding of the disorder -- 2. The neuropsychiatry of frontotemporal dementia -- 3. Nosology and Neuropathology of Language in Primary Progressive Aphasia -- 4. Measuring Behavior and Cognition in FTLD -- 5. Clinical update on C9orf72: FTD, ALS and beyond -- 6. Clinical aspects of familial FTLD associated with MAPT and GRN mutations -- 7. Neuroimaging in Frontotemporal Lobar Degeneration -- 8. The FTD Prevention Initiative - linking together genetic FTD cohort studies -- 9. Fluid Biomarkers of Frontotemporal Lobar Degeneration -- 10. Cross-cultural perspectives on frontotemporal degeneration -- 11. Clinical characteristics and Neuropathology of PSP, CBD and Related 4R-Tauopathies -- 12. Tau protein and frontotemporal dementias -- 13. FTLD-TDP pathological subtypes: clinical and mechanistic significance -- 14. Lysosomal dysfunction as a pathogenic mechanism in FTD: Evidence from PGRN and TMEM106B genetics and biology -- 15. Future trends in understanding the pathological role of TDP-43 and FUS proteins -- 16. Description of a new data resource for FTD including multiomic data on human post mortem brain (MAPT, GRN, C9orf72), matching mouse models and iPS models -- 17. Mendelian and sporadic FTD: avenues from genetics to disease pathways through in-silico prediction and modeling -- 18. FTLD treatment: Current Practice and Future Possibilities.
    Abstract: Under the name of Frontotemporal Dementias (FTD) numerous hereditary and sporadic disorders are listed. FTD may take away speech and language, social skills and ethical judgement, wishes and will, empathy and emotions; it may also impair motor functions. FTD may affect men and women in midlife or during old age leading to the demolition of the uniqueness of the human mind. In the last decade of the 20th century and in the first two decades of the 21st century, progress in the understanding of clinical, neuropathological, biochemical, and genetic aspects of FTD has accelerated. The novel awareness about FTD has directed young generations of researchers toward the study of this complex group of disorders. This Volume has been formulated with the participation of some of the leading scientists who have contributed to the development of knowledge in the clinical and basic science arenas. It captures the current central elements that are relevant to an up-to-date understanding of causes and pathogenesis of multiple forms of FTD. The volume is an opus that represents a distillation of the work of many scientists and addresses the current directions in the study of one of the most complex groups of diseases. In view of its structure, the book could also be used as a textbook, that offers both a broad and deep analysis of major areas in FTD. This book, planned by the International Society for Frontotemporal Dementias, is distinctive as it opens a window to a wide landscape about the biology of FTD. Thus, the book represents a moment of reflection on the present state of our knowledge of FTD and a collective vision toward scientific progress. The authors of each chapter share their knowledge and vision aimed at reducing the suffering which is caused by FTD.
    Type of Medium: Online Resource
    Pages: X, 320 p. 46 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030511401
    Series Statement: Advances in Experimental Medicine and Biology, 1281
    DDC: 612.8
    Language: English
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    Keywords: Medical sciences. ; Radiology. ; Neurology . ; Health Sciences. ; Radiology. ; Neurology.
    Description / Table of Contents: The subcortical space: anatomy of the subcortical white matter -- Common pathology of the subcortical region -- The ventricular system: Anatomy and common lesions -- Advanced neuro-imaging of the subcortical space -- Advanced neuro-imaging of the human ventricular system -- The evolution of trans-sulcal, channel-based parafascicular surgery -- Open transcortical approaches to subcortical lesions -- Traditional open and neuro-endoscopic approaches to intraventricular pathology -- Trans-sulcal, channel-based parafascicular surgery: Technological considerations and instrumentation -- Standard parafascicular approaches to subcortical regions -- Trans-sulcal, channel-based parafascicular surgery: Basic concepts and a general overview -- Trans-sulcal, channel-based parafascicular surgery for brain metastases -- Trans-sulcal, channel-based parafascicular surgery for gliomas and other primary, intrinsic subcortical tumors -- Trans-sulcal, channel-based parafascicular biopsy techniques -- Trans-sulcal, channel-based parafascicular surgery for intraventricular lesions -- Trans-sulcal, channel-based parafascicular surgery for intracerebral hematoma (ICH) -- Trans-sulcal, channel-based parafascicular surgery for cavernous angiomas and other vascular lesions -- Trans-sulcal, channel-based parafascicular surgery for tumors; Adjunctive measures and techniques -- Case selection and surmounting the learning curve -- Future directions.
    Abstract: This book will be the definitive reference on surgery of the subcortical region. It comprehensively discusses all aspects of treatment of subcortical and intraventricular lesions, including neuroanatomy and neuroimaging of the subcortical space, principles of parafascicular subcortical channel-based surgery, common indications and approaches, and focused chapters for common subcortical lesions. The first section of the reference focuses on the intricate anatomy and neuro-imaging of the subcortical space and ventricular system, with special emphasis on intricate white matter tracts and diffusion tractography imaging. The next section of the book discusses principles of both open and parafascicular, channel-based approaches to subcortical and intraventricular lesions, in addition to workhorse approaches to common subcortical compartments. Finally, specific pathological subcortical lesions that can be commonly addressed via parafascicular channel-based approaches, including brain metastases, gliomas, and intracerebral hemorrhage are addressed. Authored by experts in the field of subcortical neurosurgery, this book was developed to provide a unique, comprehensive text for neurosurgeons, neuro-radiologists, and trainees from a variety of specialties interested in evolving minimally disruptive access and treatment of the subcortical space.
    Type of Medium: Online Resource
    Pages: XII, 257 p. 94 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030951535
    DDC: 610
    Language: English
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    Keywords: Neurosciences. ; Neurology . ; Pharmaceutical chemistry. ; Cognitive neuroscience. ; Neuroscience. ; Neurology. ; Pharmaceutics. ; Cognitive Neuroscience.
    Description / Table of Contents: Part I: Basic Science of Cerebellum and Ataxias -- Functional anatomy of the cerebellum -- Cerebellar physiology -- Cerebellar biochemistry/pharmacology -- Genetics of dominant ataxias -- Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics -- Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches -- Ion Channel Genes and Ataxia -- Part II: Biomarkers and tools of trials -- How to Design a Therapeutic Trial in SCAs -- Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers -- Clinical rating scales for ataxia -- Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding -- Cerebellar learning in the prism adaptation task -- Blood and CSF biomarkers in autosomal dominant cerebellar ataxias -- Part III: Autosomal Dominant Cerebellar Ataxias -- Riluzole in progressive cerebellar ataxias -- ASOs against ATXN2 in preclinical and phase 1 trials -- Antisense oligonucleotide therapy against SCA3 -- Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities -- Experimental neurotransplantation for cerebellar ataxias -- Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside -- Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia -- Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias -- Physical therapy in Cerebellar Ataxia -- Part IV: Autosomal Recessive Cerebellar Ataxias -- Recent advances on therapeutic approaches for Friedreich’s Ataxia -- Therapeutic use of interferon gamma in Friedreich ataxia -- Metabolic treatments of cerebellar ataxia -- Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome -- Part V: Sporadic Ataxias -- Therapeutic strategies in immune-mediated cerebellar ataxias -- Coenzyme Q10 in MSA -- State of the Art and History of Therapeutics in Ataxias.
    Abstract: Despite the critical importance of the cerebellum in brain functions, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
    Type of Medium: Online Resource
    Pages: XI, 727 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031243455
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 20
    Keywords: Neurosciences. ; Nervous system Diseases. ; Neurology . ; Neurophysiology. ; Neuropsychology. ; Neurons. ; Neuroscience. ; Neurological Disorders. ; Neurology. ; Neurophysiology. ; Neuropsychology. ; Cellular Neuroscience.
    Description / Table of Contents: Introduction: Neuroglia in psychiatric disorders -- Chapter 1. Astrocytes: The housekeepers and guardians of the CNS -- Chapter 2. Principles of astrogliopathology -- Chapter 3. Morphological appearance of astroglia in neuropsychiatric disorders -- Chapter 4. Astrocytes and neurotransmission: Glutamate and GABA in cognitive and mood disorders -- Chapter 5. Astroglia in bipolar disorder -- Chapter 6. Astroglia abnormalities in mood disorders -- Chapter 7. Astroglia in major depression and suicide -- Chapter 8. Neuroglia in Schizophrenia -- Chapter 9. Glutamate turnover in Schizophrenia -- Chapter 10. Astroglia and dopanime transmission in Schizophrenia -- Chapter 11. Kynurenic acid in Schyzophrenia -- Chapter 12. Astrocytes in addictive disorders -- Chapter 13. Astroglia in the vulnerability and maintenance of alcohol dependence -- Chapter 14. Astroglia in response to stress -- Chapter 15. Astroglia and Obsessive compulsive disorder -- Chapter 16. Astrocytes in regulation of food intake -- Chapter 17. Astrocytes in anorexia nervosa -- Chapter 18. Astroglial serotonin receptors as the central target of classic antidepressants -- Chapter 19. Lithium targets astrocytes -- Epilogue.
    Abstract: This contributed volume discusses the multiple roles of astrocytes, which determine the progression and outcome of neuropsychiatric diseases. This emerging area of study examines the ways in which astrocytes are involved in various aspects of disease initiation, progression and resolution. This monograph aims to integrate the body of information that has accumulated in recent years revealing the active role of astrocytes in neuropsychiatric pathology and in psychiatric disorders. Understanding roles of astrocytes in pathology will provide new targets for medical intervention and aid the development of much needed therapeutics. This book will be valuable for researchers and workers in the fields of neurobiology, neurology, and psychiatry, as well as fill the need for a textbook used in advanced courses/graduate seminars in glial pathophysiology.
    Type of Medium: Online Resource
    Pages: VI, 377 p. 36 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030773755
    Series Statement: Advances in Neurobiology, 26
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuropsychology. ; Neurology . ; Neuroscience. ; Neuropsychology. ; Neurology.
    Description / Table of Contents: Chapter 1: Understanding the Mechanisms of Dendritic Arbor Development: Integrated Experimental and Computational Approaches -- Chapter 2: Autophagy Mechanisms for Brain Recovery. Keep It Clean, Keep It Alive -- Chapter 3: Environmental enrichment and functional plasticity in the hippocampus, an update on the mechanisms involved -- Chapter 4: Translatable Models of Brain and Cognitive Reserve -- Chapter 5: Cognitive Reserve: A Life-Course Perspective -- Chapter 6: Neural Correlates of Brain Reserve: A Neuroimaging Perspective -- Chapter 7: Non-pharmacological Approaches Based on Mind-Body Medicine to Enhancement of Cognitive and Brain Reserve in Humans -- Chapter 8: Roles of Synaptic Plasticity in Functional Recovery After Brain Injury -- Chapter 9: Integrated Methods of Neuromodulation for Guiding Recovery Following Stroke -- Chapter 10: Resilience in Brain Networks After Stroke -- Chapter 11: Epigenetics and brain plasticity: back to function -- Chapter 12: Functional Role of Physical Exercise and Omega-3 Fatty Acids on Depression and Mood Disorders -- Chapter 13: BRAIN RECOVERY IN CHILDHOOD: THE INTERACTION BETWEEN DEVELOPMENTAL PLASTICITY AND REGENERATIVE MECHANISMS -- Chapter 14: Estrogen Neuroprotective Activity After Stroke and Spinal Cord Injury -- Chapter 15: Making Meaning of Acquired Brain Injury: Resources for Functional Recovery -- Chapter 16: An Update on Premorbid Personality Traits and Brain Recovery - Another Aspect of Resilience -- Chapter 17: Psychological Aspects of Recovery After Brain Injury: A Focus on Psychodynamic Factors -- Chapter 18: Artificial Intelligence applications for Traumatic Brain Injury research and clinical management.
    Abstract: The importance of this unique book's approach lies in addressing the impact of neurobiological factors as well as psychological influences on brain recovery following injury. There is growing evidence that emotional, motivational, and cognitive factors along with personality traits play a crucial role in brain plasticity, resilience, and recovery. Topics include synaptic and neuronal plasticity, development of brain reserves, biological markers, environmental factors, emotional resilience, and personality traits. By combining the latest research on neural mechanisms and psychological resilience the authors present a book that will help lead to the development of better treatment strategies for functional recovery from brain damage. The new edition is fully updated throughout and contains completely new chapters on brain recovery in childhood, epigenetic aspects of brain recovery, and artificial intelligence techniques in traumatic brain injury research.
    Type of Medium: Online Resource
    Pages: XXIV, 406 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031249303
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 22
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Immunology. ; Neurology . ; Neurosciences. ; Diseases. ; Pharmacology. ; Immunology. ; Neurology. ; Neuroscience. ; Diseases. ; Pharmacology.
    Description / Table of Contents: Pro and Anti-Inflammatory Neurovascular Processes in Epilepsy: A Fragile and Dynamic Equilibrium -- Emerging Molecular Mechanisms of Neuroinflammation in Seizure Disorders -- Glial Mechanisms of Inflammation during Seizures -- Perivascular Inflammation and Extracellular Matrix Alterations in Blood-Brain Barrier Dysfunction and Epilepsy -- Blood T cells and Cytokine Levels during Interictal-Ictal Transitions -- Autoantibodies, Encephalopathies and Epilepsy -- Tau Protein in Drug-Resistant Epilepsy and Cognitive Decline -- Ketogenic Diet, Inflammation and Epilepsy -- Role of Regulatory T cells in Epilepsy -- Inflammation at the Neurovascular Unit in Post-Traumatic Epilepsy.
    Abstract: This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.
    Type of Medium: Online Resource
    Pages: VIII, 237 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030674038
    Series Statement: Progress in Inflammation Research, 88
    DDC: 571.96
    Language: English
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  • 23
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Neurology . ; Neurosciences. ; Nervous system Diseases. ; Biomedical Research. ; Neurology. ; Neuroscience. ; Neurological Disorders.
    Description / Table of Contents: PART I: Fundamental Aspects -- Chapter 1. Definition of Tremor -- Chapter 2. Membrane Mechanisms of Tremor -- Chapter 3 Advances in the Genetics of Human Tremor -- Chapter 4. Two origins of tremors related to the Guillain-Mollaret triangle: the forward model-related tremor and the inferior olive oscillation-related tremor -- PART II:Tremor in Clinical Practice -- Chapter 5. Physiologic Tremor -- Chapter 6. Rest Tremor -- Chapter 7. Postural Tremors -- Chapter 8. Isometric Tremor -- Chapter 9. Essential Tremor and Other Forms of Kinetic Tremor -- Chapter 10. Cerebellar lesions and tremor -- Chapter 11. Orthostatic Tremor -- Chapter 12. Posttraumatic Tremor and Other Posttraumatic Movement Disorders -- Chapter 13 Tremor in Childhood -- Chapter 14. Metabolic Causes of Tremor -- Chapter 15. Drug-Induced Tremor -- Chapter 16. Tremor: The Clinical Approach to Reach the Diagnosis -- PART III: Assessment of tremor -- Chapter 17. Signal Processing -- Chapter 18. Diffusion imaging in Tremor -- Chapter 19. The role of the noradrenergic system in tremor pathogenesis -- Chapter 20. Metabolic Networks in Parkinson’s Disease -- PART IV: Therapies -- Chapter 21. Deep brain stimulation for tremor -- Chapter 22 Mechatronic Devices for Upper Limb Tremor.
    Abstract: Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.
    Type of Medium: Online Resource
    Pages: X, 558 p. 86 illus., 59 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031261282
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 610.72
    Language: English
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    Keywords: Computational neuroscience. ; Biomedical engineering. ; Neurology . ; Neurophysiology. ; Neuroanatomy. ; Image processing. ; Computational Neuroscience. ; Biomedical Engineering and Bioengineering. ; Neurology. ; Neurophysiology. ; Nervous System. ; Image Processing.
    Description / Table of Contents: 1. Physiology of Brain-Heart Interplay -- 2. Brain and Heart Signal Processing Methodology -- 3. Quantification of Functional Brain-Heart Interplay -- 4. Exemplary Applications to Real Brain and Heartbeat Data -- 5. Future Direction of Research and Prospective Applications using Functional Brain-Heart Interplay Assessment.
    Abstract: This monograph offers a cross-system exchange and cross-modality investigation into brain-heart interplay. Brain-Heart Interplay (BHI) is a highly interdisciplinary scientific topic, which spreads from the physiology of the Central/Autonomous Nervous Systems, especially Central Autonomic Network, to advanced signal processing and modeling for its activity quantification. Motivated by clinical evidence and supported by recent findings in neurophysiology, this monograph first explores the definition of basic Brain-Heart Interplay quantifiers, and then moves onto advanced methods for the assessment of health and disease states. Non-invasive use of brain monitoring techniques, including electroencephalogram and function Magnetic Resonance Imaging, will be described together with heartbeat dynamics monitoring through pulseoximeter and ECG signals. The audience of this book comprises especially of biomedical engineers and medical doctors with expertise in statistics and/or signal processing. Researchers in the fields of cardiology, neurology, psychiatry, and neuroscience in general may be interested as well.
    Type of Medium: Online Resource
    Pages: X, 236 p. 109 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030799342
    DDC: 612.8
    Language: English
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  • 25
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Neurosciences. ; Human physiology. ; Neurology . ; Neuroscience. ; Human Physiology. ; Neurology.
    Description / Table of Contents: Chapter 1. Neurophysiology and Respiratory system -- Chapter 2. Normal physiology of Respiratory System -- Chapter 3. Brain – Lung crosstalk.
    Abstract: The central nervous system, which includes the brain and spinal cord, has a high metabolic demand. The physiology of the brain is such that it is easily affected by alterations in other systems, which in turn can compromise cerebral blood flow and oxygenation. Together the brain and spinal cord control the automatic function of our body systems. While other systems of body controls individual functions, central nervous system at the same time does many different functions, especially, controlling the function of other systems. This interaction between the brain and other systems is important when it comes to understanding how injuries to the brain can, at times, produce complications in remote organs or systems of the body, such as the lungs. This book explains the lesser-known crosstalks between acutely or chronically affected brain and lung, describing the pathophysiology of the lung following brain injury and discussing in detail the conflicts between the brain and lungs in relation to the tidal volumes, positive end-expiratory pressures, arterial carbon dioxide and oxygen levels, recruitment maneuvers and positioning, as well as potential therapeutic targets. .
    Type of Medium: Online Resource
    Pages: XIII, 103 p. 27 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811523458
    Series Statement: Physiology in Clinical Neurosciences – Brain and Spinal Cord Crosstalks,
    DDC: 612.8
    Language: English
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  • 26
    Keywords: Human physiology. ; Neurosciences. ; Pharmacology. ; Hematology. ; Neurology . ; Human Physiology. ; Neuroscience. ; Pharmacology. ; Hematology. ; Neurology.
    Description / Table of Contents: Structure of the Mammalian Choroid Plexus -- Blending Established and New Perspectives on Choroid Plexus-CSF Dynamics -- A Frog Model for CSF Secretion -- Cotransport of Water in the Choroid Plexus Epithelium: From Amphibians to Mammals -- The Significance of the Choroid Plexus for Cerebral Iron Homeostasis -- Acid/Base Transporters in CSF Secretion and pH Regulation -- TRPV4, a Regulatory Channel in the Production of Cerebrospinal Fluid by the Choroid Plexus -- Neuroprotective Mechanisms at the Blood-CSF Barrier of the Developing and Adult Brain -- Roles of the Choroid Plexus in Aging -- Choroid Plexus Tumors -- Roles of the Choroid Plexus in CNS Infections -- Hydrocephalus.
    Abstract: This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue. Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroid plexus is not only important for the readers’ understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia. Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.
    Type of Medium: Online Resource
    Pages: VI, 287 p. 65 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9781071605363
    Series Statement: Physiology in Health and Disease,
    DDC: 612
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Surgery. ; Dentistry. ; Veterinary medicine. ; Neurology . ; Orthopedic surgery. ; Pharmacology. ; Surgery. ; Dentistry. ; Veterinary Science. ; Neurology. ; Surgical Orthopedics.
    Description / Table of Contents: 1. History of development of botulinum toxin therapy in medical and surgical fields -- 2. Molecular structure and mechanisms of action of botulinum toxins as it pertains to clinical symptoms -- 3. Types of toxins in commercial use, their similarities and differences -- 4. A review of current Botulinum toxin treatment indications in medical field. - 5. Mechanisms of Analgesic effects of botulinum neurotoxins -- 6. Botulinum toxin treatment in Head and neck surgery -- 7. Botulinum toxin treatment of thoracic and abdominal surgery -- 8. Botulinum Toxin A in Abdominal Wall Reconstruction -- 9. Use of Botulinum toxin A in post-mastectomy breast reconstruction -- 10. Botulinum Toxins for Treatment of Pain in Orthopedic Disorders -- 11. Botulinum toxin for pediatric patients, Who? For what? When? -- 12. Botulinum Toxin Treatment in Plastic Surgery -- 13. Botulinum Toxin Treatment in Ophthalmology and Ophthalmic surgery -- 14. Botulinum Toxin Treatment in Gastrointestinal Disorders -- 15. Botulinum Toxin Treatment in Urological Disorders -- 16. Botulinum Toxin Treatment in Dentistry -- 17. Botulinum toxin treatment in Veterinary Medicine - Clinical implications -- 18. Future Perspectives of Botulinum Toxin Application In Dentistry.
    Abstract: All books on the market which have been written on the subject of botulinum toxin therapy focus on treatment of hyperactive movement disorders, autonomic dysfunction (bladder, sweat and salivary glands) and some pain indications (migraine). Reference to pre-or post -surgical indications are brief and often out-dated. No book has information on dentistry or veterinary medicine. This book provides up-to-date information on botulinum toxin therapy in surgical fields. It is also the only book in the market that provides information on botulinum toxin therapy in dentistry and veterinary medicine and furnishes the latest information. Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine appeals to many disciplines including surgery, dentistry and veterinary medicines well as appealing to neurologists and internists.
    Type of Medium: Online Resource
    Pages: VIII, 398 p. 70 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030506919
    DDC: 615
    Language: English
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    Keywords: Clinical biochemistry. ; Neurology . ; Medical Biochemistry. ; Neurology.
    Description / Table of Contents: Part 1. Basics of Neurochemistry -- Chapter 1. Molecular biology of nervous system -- Chapter 2. Basics of neurotransmitters and signal transmission -- Chapter 3. Chemistry of neurochemicals- Psychopharmaceuticals and neuropeptides -- Chapter 4. Exploring the Chemical makeup of Human brain -- Chapter 5. Chemical agents in nervous system -- Part 2. Revisiting Neurodegenerative diseases -- Chapter 6. Pathophysiology of Neurodegenerative diseases-Basics to advanced -- Chapter 7. Revisiting Alzheimer’s disease -- Chapter 8. Advancement and challenges in Parkinson’s disease research -- Chapter 9. Post-traumatic stress disorders -- Chapter 10. Neuropharmacology- Looking forward to the future.
    Abstract: This book provides medical professionals and researchers with a comprehensive overview of fundamental concepts and recent advances in neurochemistry, and offers new perspectives for all those involved with research in related disciplines. As drug discovery for neurodegenerative diseases is one of the largest subspecialties in the field of medicine, the book addresses topics that transcend the borders between disciplines, and presents a wealth of investigations into and discussions on critical questions relevant to the entire field of CNS drug research. It summarizes the available data on the fundamentals of neurotransmitters, treatment of and advanced care for neurodegenerative diseases; and outlines current and future research directions in this field. Combining both conventional and innovative approaches to the topic, the book offers a valuable guide for readers working in medicinal chemistry, the life sciences and allied fields. .
    Type of Medium: Online Resource
    Pages: XI, 194 p. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811551673
    DDC: 612.015
    Language: English
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    Keywords: Neurosciences. ; Cytology. ; Biotechnology. ; Neuropsychology. ; Neurology . ; Neuroscience. ; Cell Biology. ; Biotechnology. ; Neuropsychology. ; Neurology.
    Description / Table of Contents: Part 1. Light-sensitive channels and transporters -- 1. History and Perspectives of Light-Sensing Proteins -- 2. Phototactic behavior of Chlamydomonas -- 3. Structure-Functional Analysis of rhodopsin light sensors -- 4. Molecular Dynamics of Channelrhodopsin -- 5. Photochemistry of Halorhodopsin -- 6. Spectroscopic Dynamics of Microbial Rhodopsins -- 7. Molecular Engineering of Retinylidene Proteins -- 8. A new optogenetic tools from deep ocean -- Part 2. Light-sensitive signaling molecules -- 9. Biology of Light-Sensing Proteins in Plants and Microorganisms -- 10. Optogenetic Potentials of Diverse Animal Opsins -- 11. Enzyme rhodopsins -- 12.Optogenetic photoswitches -- 13.Genetic, biochemical and biophysical studies on flavoprotein photoreceptors -- Part 3. Optogenetics in Biological System -- 14. General Description: Future Prospects of Optogenetics -- 15. Optogenetic Manipulation and Probing -- 16. Visualization and Manipulation Signaling Molecules In Vivo -- 17. Optical Manipulation of Gene Expression -- 18. Optical Manipulation of Intracellular Signaling -- 19. Single Molecule Optogenetics -- 20. Bioluminescence Imaging -- 21. Luminescence Optogenetics -- 22. Optogenetic Imaging of Protein Activity in the Synapse Using 2-Photon Fluorescence Lifetime Imaging Microscopy -- 23. Optogenetics in Drosophila -- 24. Optogenetics in Caenorhabditis elegans -- 25. Optogenetics in zebrafish -- 26. Optogenetics Research Using the Mouse as a Model System -- 27. Optogenetics Research Using Rat -- 28. Optogenetics Research Using Primates -- 29. Organelle Optogenetics -- Part 4. Optogenetics in Neuroscience -- 30. Neuroscientific Frontline of Optogenetics -- 31. Elucidation of Neuronal Circuitry Involved in the Regulation of Sleep/Wakefulness Using Optogenetics -- 32. Multiscale neural activity in the behaving brain -- 33. Optogenetic Analysis of Striatal Connections to Determine Functional Connectomes -- 34. Optogenetics for the Behavior Manipulation of Non-human Primates -- 35. Activity Regulation in the Study of Neural Plasticity -- 36. Optogenetic Control of Synaptic Plasticity -- 37. Casting Light on the Role of Glial Cells in Brain Function -- 38. Optogenetic manipulation of Respiratory Rhythm -- 39. Optogenetic mapping of brain circuitry -- 40. In vivo imaging of Arc transcription -- 41. Neural Circuits for the Formation and Retrieval of Episodic Memories -- Part 5. Medical Optogenetics -- 42. Medical Optogenetics, Overview -- 43. Towards Understanding the Neural Mechanism of Behavioral Phenotypes Seen in Psychiatric Disorders -- 44. Gene Therapy Using Channelrhodopsins to Treat Blindness -- 45. Optogenetic Approaches to Restoring Intrinsic Visual Processing Features in Retinal Ganglion Cells -- 46. Application of optogenetics to epilepsy research -- Part 6. Opto-electro-nano Technologies for Optogenetics -- 47. CMOS-Based Neural Interface Device for Optogenetics -- 48. OLED System for Optogenetics -- 49. Micro-imaging probes, Opto-electrodes, and Virtual Reality Systems for Optogenetics -- 50. Upconversion -- 51. Optical probes for in vivo optogenetics.
    Abstract: This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a “must read” for all involved in research in any way related to optogenetics.
    Type of Medium: Online Resource
    Pages: XII, 663 p. 241 illus., 197 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9789811587634
    Series Statement: Advances in Experimental Medicine and Biology, 1293
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Biomedical engineering. ; Neurology . ; Radiology. ; Biophysics. ; Neuroscience. ; Biomedical Engineering and Bioengineering. ; Neurology. ; Radiology. ; Biophysics.
    Description / Table of Contents: Introduction to Neurophysiology -- Biopotential Measurements and Electrodes -- EEG Signal Processing: Theory and Applications -- Brain-Computer Interfaces -- Intracortical Brain Machine Interfaces -- Deep Brain Stimulation: Emerging Technologies and Applications -- Transcranial Magnetic Stimulation: Principles and Applications -- Transcranial Electrical Stimulation -- Optogenetics: Novel Brain Interface Technology that Originates in Bioprospecting -- Selective Chronic Recording in the Peripheral Nervous System -- Functional Magnetic Resonance Imaging -- Photoacoustic Tomography of Neural Systems -- Electrophysiological Mapping and Source Imaging -- Exploring Functional and Causal Connectivity in the Brain -- Deep Learning Models with Applications to Brain Image Analysis -- Neural Modeling -- Linear Dynamics & Control of Brain Networks -- Deciphering the Neuronal Population Code -- Machine Intelligence Based Epileptic Seizure Forecasting -- Retinal Prosthesis -- Retinal Bioengineering -- Neural Tissue Engineering -- Index.
    Abstract: This third edition overviews the essential contemporary topics of neuroengineering, from basic principles to the state-of-the-art, and is written by leading scholars in the field. The book covers neural bioelectrical measurements and sensors, EEG signal processing, brain-computer interfaces, implantable and transcranial neuromodulation, peripheral neural interfacing, neuroimaging, neural modelling, neural circuits and system identification, retinal bioengineering and prosthetics, and neural tissue engineering. Each chapter is followed by homework questions intended for classroom use. This is an ideal textbook for students at the graduate and advanced undergraduate level as well as academics, biomedical engineers, neuroscientists, neurophysiologists, and industry professionals seeking to learn the latest developments in this emerging field. Advance Praise for Neural Engineering, 3rd Edition: “A comprehensive and timely contribution to the ever growing field of neural engineering. Bin He’s edited volume provides chapters that cover both the fundamentals and state-of-the-art developments by the world’s leading neural engineers." Dr. Paul Sajda, Department of Biomedical Engineering, Electrical Engineering and Radiology, Columbia University “Neural Engineering, edited by Prof. He, is an outstanding book for students entering into this fast evolving field as well as experienced researchers. Its didactic and comprehensive style, with each chapter authored by leading scientific authorities, provides the ultimate reference for the field.” Dr. Dario Farina, Department of Bioengineering, Imperial College London, London, UK "Neural Engineering has come of age. Major advances have made possible prosthesis for the blind, mind control for quadraplegics and direct intervention to control seizures in epilepsy patients. Neural Engineering brings together reviews by leading researchers in this flourishing field. Dr. Terrence Sejnowski, Salk Institute for Biolgical Studies and UC San Diego.
    Type of Medium: Online Resource
    Pages: XVI, 699 p. 407 illus., 299 illus. in color. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783030433956
    DDC: 612.8
    Language: English
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    Keywords: Human physiology. ; Neurology . ; Anatomy. ; Neurosciences. ; Internal medicine. ; Human Physiology. ; Neurology. ; Anatomy. ; Neuroscience. ; Internal Medicine.
    Description / Table of Contents: Salivary gland: Savilon -- Oesophageal sphincters: Upper oesophageal sphincter and lower oesophageal sphincter -- Stomach as an Acid Producer -- Homeostasis of gastric acid secretion: neurocrine, paracrine and endocrine system, proton pump inhibitors. Alkaline tide -- Gastric mucosal barrier, Helicobacter pylori -- Gastric motility: (Migrating Motor Complex, Receptive Relaxation, Accommodation, Retropulsion) -- Gastric Emptying -- Gastrointestinal Rhythmic Contractions Electrical Basis: Slow wave potential -- Migratory Motor Complex (or migrating myoelectric complex), MMC, Motilin -- Motility: Peristalsis, Segmentation, Haustration and Mass movement -- Motility: Peristalsis, Segmentation, Haustration and Mass movement -- Recycling of bile salts: Enterohepatic Circulation (EHC) -- Intestinal Fluid Handling: Absorption -- Intestinal Fluid Handling: Secretion -- Pancreatic Exocrine function: Pancreatic acinar cell in pancreatic secretion, cholecystokinin (CCK), Auto- digestion -- Pancreatic Exocrine function: Pancreatic ductal cell, CFTR chloride channel. Secretin -- Carbohydrate Digestion: Small intestine as the site of digestion and absorption for dietary carbohydrate -- Fat digestion: Bile salt, emulsification, micelles, lipases, chylomicrons -- Protein Digestion -- Protein Absorption -- Defecation Reflex: Parasympathetic defecation reflex, intrinsic myenteric defection reflex -- Resting Membrane Potential (RMP) -- Equilibrium Potential -- Membrane conductance -- Action Potential -- Neuronal excitability -- Neuronal refractory period -- Initiation zone -- Saltatory conduction -- Firing rate -- Post-synaptic potentials -- Synaptic delay -- Summation -- Neurotransmitter -- Presynaptic inhibition -- Adequate stimulus -- Stimulus transduction -- Stimulus coding -- Adaptation -- Sensory discrimination (acuity) -- Motor neurons -- Neuromuscular junction -- Proprioception -- Spinal reflex -- Alpha-gamma coactivation.
    Abstract: This second volume of Defining Physiology: Principles, Themes, Concepts. continues on the same format as the first. In this new release, a selection of 44 essential topics in each major organ system is defined, then major themes, concept and principles surrounding these words in their physiologic scenarios are elaborated. For each keyword, a question is posed at the end of the text to test for a better understanding of the associated physiology of nervous and gastrointestinal systems. This book presents an easy reference guide for those just starting out in the area of physiology and for those who are interested in clear and succinct definitions of key terms.
    Type of Medium: Online Resource
    Pages: XII, 112 p. 42 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030622855
    DDC: 612
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Cognitive psychology. ; Neuropsychology. ; Psychiatry. ; Philosophy of mind. ; Neurology . ; Neuroscience. ; Cognitive Psychology. ; Neuropsychology. ; Psychiatry. ; Philosophy of Mind. ; Neurology.
    Description / Table of Contents: Learning the Languages -- Humanity’s Search for Mind and the Subject: A Brief Review of the Evolution of Neuropsychobiology -- An “Ideographic,” Suprapersonal Language of Rules and Universal Symbols: Alwyn Scott and Nonlinear Dynamics -- A “Demotic,” First-Person Language of the Individual and the Social System: Apuleius and the Myth of Psyche -- The Language of the Objective Observer: Gerald Edelman and Neurodarwinism: Antonio Damasio and the Feeling of Knowing -- Seeking the Understanding -- Consciousness -- The Unconscious -- The Database -- Affectivity -- The Neural/Mental Gap: Intuition, Self and Ego, a Trilingual Map -- Applying the Knowledge -- The Three Languages and Science: A New Scientific Paradigm? -- The Three Languages and Treatment -- The Psychotherapeutic Dialogue: Intersubjectivity -- The Role of a New Science for Psyche Upon Society and Culture.
    Abstract: The study of the brain-mind complex has been hampered by the dichotomy between objective biological neuroscience and subjective psychological science. The two antithetical avenues of research are partly responsible for the failure to unravel the transformation of neural events into mental images: how matter becomes imagination, and vice versa; is the brain’s consciousness equivalent to Ego consciousness? Is the ego the self? In its new and updated edition, “The Rosetta Stone of the Human Mind: Three Languages to Integrate Neurobiology and Psychology” illustrates how the simultaneous use of the languages of neurobiology, of mathematics, and of the humanities, enriches the understanding of the neural and mental realms and adds new dimensions to our perception of neuropsychological events. Dr. Sanguineti shows how the two seemingly dichotomous approaches are similar in what they describe, and he explores how the awareness and application of these perspectives are helpful in getting a deeper theoretical grasp on major mental events, giving us a better understanding of individual minds, and fostering a more integrated therapeutic intervention. The intended readers include neuroscientists, psychiatrists, psychologists, and anyone interested in the human mind. Describes a model integrating biological neuroscience principles, subjective psychological science, and nonlinear physics and mathematics Offers a wide-ranging, holistic exploration of the mind and its conscious and unconscious realms, using myth, art, philosophy, neurobiology and basic sciences Introduces the future new paradigm for emergent science, the Poem, to replace the outdated classical reductionistic paradigm of the Machine.
    Type of Medium: Online Resource
    Pages: XXII, 167 p. 25 illus., 6 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030864156
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Psychiatry. ; Neurology . ; Neuroscience. ; Psychiatry. ; Neurology.
    Description / Table of Contents: A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Z.
    Abstract: The Dictionary of Hallucinations, second edition, is an alphabetical listing of issues pertaining to hallucinations and other misperceptions. They can be roughly divided into four categories: 1. Definitions of individual hallucinatory symptoms 2. Medical conditions and substances associated with the mediation of hallucinations 3. Historical figures who are known to have experienced hallucinations 4. Miscellaneous issues Each of the definitions of individual hallucinatory symptoms includes: a definition of the term its etymological origin the year of introduction (if known) a reference to the author or authors who introduced the term (if known) a description of the current use a brief explanation of the etiology and pathophysiology of the symptom at hand (if known) references to related terms references to the literature The second edition of A Dictionary of Hallucinations serves as a reference manual for neuroscientists, psychiatrists, psychiatric residents, psychologists, neurologists, historians of psychiatry, general practitioners, and academics dealing professionally with concepts of hallucinations and other sensory deceptions. This new edition provides updated information and references, and includes newly discovered hallucinations, bringing together contributions by other authorities within the field, with all the entries edited by Prof. Blom.
    Type of Medium: Online Resource
    Pages: XXVI, 790 p. 604 illus., 364 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031252488
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neurology . ; Neuropsychology. ; Pharmacology. ; Neuropharmacology. ; Psychiatry. ; Neuroscience. ; Neurology. ; Neuropsychology. ; Pharmacology. ; Neuropharmacology. ; Psychiatry.
    Description / Table of Contents: Treatments Against Glutamatergic Excitotoxicity in Ischemic Stroke -- Definitions and Concepts of Stress -- Role of Glutamatergic Neurotransmission in the Pathophysiology of Stress-Related Disorders and Chronic Stress Response -- Current Glutamatergic Treatments and Future Directions for Glutamate-Based Management of Chronic Stress and Stress-Related Disorders -- The Role of the Glutamate System in Posttraumatic Stress Disorder and Glutamate-Based Treatments -- Glutamate in Migraine Neurobiology and Treatment -- Astrocyte Glutamate Transporter EAAT2 in Alzheimer Dementia -- The Glutamatergic System as a Target for the Development of New Pharmacological Treatments of Bipolar Disorder -- CNS Glutamate in Impulsive Aggression -- Glutamatergic Treatments for Parkinsons' Disease -- The Modulation of Glutamatergic Signaling as a Potential Therapeutic Strategy for Major Depression -- Glutamate-Based Treatment for Amyotrophic Lateral Sclerosis/Motor Neuron Disease -- Modulation of Glutamate for Chronic Pain Management -- Pharmacological Role of Glutamate Transporters in Substance Use Disorders -- Glutamate in Multiple Sclerosis: From Pathophysiology to Treatments -- The Role of Glutamate Dysregulation in the Etiology of ADHD -- Glutamate, Glutamatergic Drugs and Schizophrenia -- Glutamate and Epilepsy: An Insight from Temporal Lobe Epilepsy -- Glutamate Function in Anxiety Disorders and OCD: Evidence from Clinical and Translational Studies -- Modulators of Glutamatergic Signaling as Potential Treatments for Autism Spectrum Disorders.
    Abstract: This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer’s Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson’s Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.
    Type of Medium: Online Resource
    Pages: XXXV, 600 p. 43 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030874803
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Neurology . ; Neuroscience. ; Neurology.
    Description / Table of Contents: Chapter 1. Behavioral pathophysiology and psychological implications for sleep disorder in dementia -- Chapter 2. Mitochondrial dysfunction is a key player in the pathogenesis of autism spectrum disorders and Alzheimer's disease -- Chapter 3. The pathogenesis and complications associated with autism spectrum disorder and Alzheimer ’s disease: A Comparative study -- Chapter 4. Impact of common natural compound in the treatment of Alzheimer's disease -- Chapter 5. Mapping a link between mercury-toxicity and Alzheimer disease -- Chapter 6. Drug therapy of Alzheimer's disease: Cholinesterase inhibitors, NMDA Antagonists -- Chapter 7. Therapeutic potential of polyphenols in Alzheimer's therapy: Broad-spectrum and minimal side effects as key aspects -- Chapter 8. recent advances in Alzheimer's disease in relation to cholinesterase inhibitors and NMDA receptor antagonists -- Chapter 9. Genetic basis of psychotic illnesses: A comprehensive overview RNA Secondary structures in neurodegeneration -- Chapter 10. RNA secondary structures in neurodegeneration -- Chapter 11. Immunotherapy: An approach to treat Alzheimer's disease and autism spectrum disorders -- Chapter 12. Alzheimer's disease (AD) - Physiological barriers for therapy and Nanotechnological applications in the treatment -- Chapter 13. Autism spectrum disorder relationship between sleep and behavior: The effect of sleep variability exploration -- Chapter 14. Role of impaired ABC transporters in Alzheimer’s disease -- Chapter 15. Cognitive impairment and rehabilitation of children and adults with autism spectrum disorder.
    Abstract: This book talks about the multidimensional biological etiology of Alzheimer’s disease and autism spectrum disorder which leads to distinctive ways of perception, thinking and learning in affected individuals. It provides a deeper emphasis on the need for early diagnosis, continuous assessment of patients and the proper educational methods and environment required towards enabling people affected with these disorders capable of evolving and learning. This book explores alternative solutions for autism spectrum disorder based on the theory of brain plasticity, the relationship between the gut microbiota and the central nervous system along with genetic factors and toxic metal exposures which are responsible for the oxidative damage resulting in a decreased ability of the patients to use objects or response to auditory stimuli. It also identifies and provides the latest research towards dealing with memory loss, which is the first sign of cognitive impairment followed by behavioral disturbances. These symptoms are associated with a rigorous neuronal decline and the appearance of two brain lesions, senile plaques and neurofibrillary tangles, which are mainly composed of Aβ and hyper phosphorylated tau protein respectively. This book also provides the latest research towards reducing autism disorder severity such as targeting the disease with symptomatic treatments such as cholinesterase inhibitors, NMDA receptor antagonist, β-secretase and γ-secretase inhibitors, α-secretase stimulators, tau inhibitors, immunotherapy, nutraceuticals, and nano drugs. This book will not only be a good resource for professors and lecturers teaching in the area of neuroscience, medicine, biochemistry, neuroinformatics, and nanotechnology, etc. but also for professionals working in the field of occupational therapy and geriatric clinics and rehabilitation.
    Type of Medium: Online Resource
    Pages: XI, 314 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811645587
    DDC: 612.8
    Language: English
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    Keywords: Nervous system Surgery. ; Critical care medicine. ; Neurology . ; Neurosurgery. ; Intensive Care Medicine. ; Neurology.
    Description / Table of Contents: Chapter 1. Neurocritical Care : An Overview -- Part I. The Basics and Monitoring -- Chapter 2. Metabolism and Cerebral Blood Flow -- Chapter 3. Brain edema: Pathophysiology, diagnosis and treatment -- Chapter 4. Intracranial pressure: invasive methods of monitoring -- Chapter 5. Non-Invasive intracranial pressure monitoring -- Chapter 6. Brain tissue oxygen monitoring -- Chapter 7. Brain microdialysis monitoring -- Chapter 8. Jugular Bulb Oxymetry -- Chapter 9. Transcranial Doppler: Practical Applications -- Chapter 10. Eletroencephalogram in the Neurosurgical Intensive Care Unit (When a single EEG is not enough) -- Chapter 11. Radiological evaluation of post-operative complications of intracranial surgery -- Part II. General Management -- Chapter 12. Management of Intracranial Hypertension -- Chapter 13. Neuroprotection in Brain Injury -- Chapter 14. Decompressive Craniectomy - Breaking skepticism -- Chapter 15. Sedation and Analgesia in Neurocritical Patients -- Chapter 16. Hemodynamic Management in the Neurocritical Patient -- Chapter 17. Blood Transfusion Strategies in Neurocritical Care -- Chapter 18. Ventilatory strategies in the neurocritical care -- Chapter 19. Endotracheal intubation, extubation and tracheostomy. How, when and why? -- Chapter 20. Infections in Neurocritical Care Units -- Chapter 21. Acid-Base and Electrolyte Disorders in Neurocritical Care -- Chapter 22. Basic Aspects of Nutrition in Neurocritical Care -- Chapter 23. General principles of neurosurgical postoperative care -- Chapter 24. Head Injury -- Chapter 25. Spontaneous Subarachnoid Hemorrhage and the First Week After Aneurysmal Subarachnoid Hemorrhage -- Chapter 26. Hemorragic Stroke. Chapter 27. Cerebral Hemorrhage and High INR -- Chapter 28. Ischemic Stroke -- Chapter 29. Emergencies in Neuro- oncology -- Chapter 30. Hemorrhage into a Pituitary tumor -- Chapter 31. Status Epilepticus -- Chapter 32. Systemic (non-neurological) complications in the neurocritical patient -- Chapter 33. Acute Spinal Cord Disorders -- Chapter 34. General Principles of Awake Neurosurgery -- Chapter 35. TBI in Pediatric Patients -- Part III. The Outcomes -- Chapter 36. Prognostic Models in Neurocritical Care -- Chapter 37. Rehabilitation and palliative care in Neurocritical patients -- Chapter 38. Brain Death and management of the potential donor -- Chapter 39. New Pespectives.
    Abstract: This unique book discusses the management of neurocritical care patients, including basic concepts, pathophysiologic principles, monitoring, treatment indications, and factors that affect outcomes in patients requiring neurocritical care assistance. It addresses the need to improve continuing education in this area, highlighting patient care in the perioperative period. This is the first book to provide a simplified overview for neurosurgeons and neurologists to understand the neurocritical patient journey. It is divided into three parts: the first covers the basics concepts, from monitoring to the interpretation of exams; the second explores general management of specific situations encountered in intensive care and the last part includes prognostic and rehabilitation models, as well as new perspectives. Thanks to the accessible, neurosurgical specific language, the book is well suited for all professionals involved in neurocritical care, including students, but is also a valuable resource for residents and researches, as well as experienced neurosurgeons or neurologists looking for updated information and guidelines.
    Type of Medium: Online Resource
    Pages: XXI, 732 p. 122 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030665722
    DDC: 617.48
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Neurology . ; Internal medicine. ; Immunology. ; Biomedical Research. ; Biomedical Research. ; Neurology. ; Internal Medicine. ; Immunology.
    Description / Table of Contents: Chapter 1. Malignant Glioma -- Chapter 2. Benign Glioma -- Chapter3. Meningioma and Other Meningeal Tumors -- Chapter4. Epondymomas in Pediatric and Adults -- Chapter5. Medulloblastomas in Pediatric and Adults -- Chapter6. Benign and Malignant Tumors of The Pineal Region -- Chapter7. The Tumors of Choroid Plexus and Other Ventricular Tumors -- Chapter8. Embryonal Tumors of The Central Nervous System with Multilayered Rosettes and Atypical Teratoid/Rhabdoid Tumors -- Chapter9. Glioneuronal and Neuronal Tumors of the Central Nervous System -- Chapter10. Benign and Malignant Tumors of the Pituitary Gland -- Chapter11. Craniopharyngioma in Pediatric and Adults -- Chapter12. Schwannomas of Brain and Spinal Cord -- Chapter13. Other Nerve-Sheet Tumors of Brain and Spinal Cord -- Chapter14. Hemangioblastomas and Other Vascular Originating Tumors of Brain or Spinal Cord -- Chapter15. Brain and Spinal Cord Tumors of Embryonic Origin -- Chapter16. Brain and Spinal Tumors Originating from the Germ Line Cells -- Chapter17. Benign Brain and Spinal Tumors Originating from Bone or Cartilage -- Chapter18. Benign Spinal Tumors -- Chapter19. Other Less Prevalent Tumors of the Central Nervous System -- Chapter20. Brain and/or Spinal Cord Tumors Accompanied with Other Diseases or Syndromes -- Chapter21. Psychological and Psychiatric Aspects of Brain and Spinal Cord Tumors -- Chapter22. A Brief Explanation on Surgical Approaches for Treatment of Different Brain Tumors.
    Abstract: This book aims to gather the current knowledge regarding different aspects of brain and spinal cord tumors in order to more efficiently help the patients. Brain tumors comprise about 5–9% of all human neoplasms; and the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. The more we know about the nature and characteristic of brain and spinal cord tumors, the more precise decision could be made for each patient, in order to reach the best outcome. While surgical resection, chemotherapy, and radiotherapy have been considered as the standards of care for benign and/or malignant CNS tumors since a long time ago, new therapeutic approaches such as immunotherapy have been recently proposed to be considered for treatment of CNS tumors, especially as in some cases, the tumors might be inoperable or the patient may not benefit from other treatment modalities after several recurrences. The second volume of the book focuses on clinical aspects of these tumors. Accordingly, the most important brain and spinal cord tumors are specifically discussed in each chapter based on a rational outlining for all chapter in this volume: Background and epidemiology, genetics, immunology and molecular biology, histopathology and morphology, imaging and radiologic features, clinical manifestations, therapeutic approaches, surgical intervention, chemotherapy and radiotherapy, new therapeutic modalities, follow-up, and prognosis. The chapters of this volume discuss the following pathologies of brain and spinal cord tumors: malignant glioma, benign glioma, meningiomas and other meningeal tumors, ependymomas, medulloblastomas, pineal tumors, choroid plexus and ventricular tumors, neuroectodermal tumors of CNS, neuroepithelial tumors of CNS, pituitary gland tumors, craniopharyngioma, schwannomas and nerve-sheet tumors, hemangioblastomas and other vascular originating tumors, brain and spinal tumors of embryonic origin, germ line cell tumors, malignant bone or cartilage-originating tumors of brain and spine, benign bone or cartilage-originating tumors of brain and spine, brain tumors affecting the orbit globe and orbit tumors affecting the brain, CNS lymphomas, metastatic lesions of the brain and spine, malignant spinal tumors, benign spinal tumors, brain and/or spinal cord tumors accompanied with other diseases or syndromes, psychological and psychiatric aspects of brain and spinal cord tumors, a brief explanation on surgical approaches for treatment of different brain tumors. This volume of book is useful for physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists, and neuroradiologists.
    Type of Medium: Online Resource
    Pages: XXIX, 739 p. 287 illus., 159 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031237058
    Series Statement: Advances in Experimental Medicine and Biology, 1405
    DDC: 610.72
    Language: English
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  • 38
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Psychiatry. ; Neurology . ; Neuroimmunology. ; Inflammation. ; Psychiatry. ; Neurology. ; Neuroimmunology. ; Inflammation.
    Description / Table of Contents: Evolutionary aspects of infections: inflammation and sickness behavior -- Evolutionary aspects of diverse microbial exposures and mental health: focus on “old friends” and stress resilience -- Influences of the immune system and microbiome on the etiology of ASD and GI symptomology of autistic individuals -- The Microbiome and Mental Health Across the Life Span -- The immune system and depression: From epidemiological to clinical evidence -- Infections, Inflammation, and Psychiatric Illness: Review of Postmortem Evidence -- Sources and Translational Relevance of Heterogeneity in Maternal Immune Activation Models -- Infections during pregnancy and risks for adult psychosis: Findings from the New England Family Study -- Non-SARS Coronaviruses in Individuals with Psychiatric Disorders -- Herpesvirus infections in the human brain: a neural cell model of the complement system derived from induced pluripotent stem cells -- Effect of cytomegalovirus on the immune system: implications for aging and mental health -- Effect of cytomegalovirus on the brain: implications for psychiatric disorders -- Fungal forces in mental health: microbial meddlers or function fixers? -- Behavioral Changes Induced by Latent Toxoplasmosis could arise from CNS Inflammation and Neuropathogenesis -- Borreliae and Related Agents -- Therapeutic Implications of the Microbial Hypothesis of Mental Illness.
    Abstract: This volume contains up-to-date contributions written by leading experts in the role played by various microorganisms in psychiatric and neurological illness. The initial chapters present an evolutionary framework for the impact of microorganisms on behavior. This is followed by historical and epidemiological perspectives of the role of viruses in psychiatric illness. Subsequent chapters focus on different classes of microorganisms and psychiatric illnesses and emphasize diverse research approaches ranging from preclinical models to therapeutic interventions.
    Type of Medium: Online Resource
    Pages: X, 351 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031243332
    Series Statement: Current Topics in Behavioral Neurosciences, 61
    DDC: 616.89
    Language: English
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  • 39
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Immunology. ; Neurology . ; Endocrinology. ; Cardiology. ; Pharmacology. ; Immunology. ; Neurology. ; Endocrinology. ; Cardiology.
    Description / Table of Contents: Part 1 Pharmacological Basic Principles -- The impact of sex and gender in medicine and pharmacology -- Sex differences in pharmacokinetics -- Clinical pharmacological considerations in transgender medicine -- Sex and gender differences in the pharmacology of the overactive urinary bladder -- Part 2 Pathologies of the Brain -- Sex differences in the evaluation and treatment of stroke -- Sex differences in pain and its treatment -- Therapeutics For Substance-Using Women: The Need To Elucidate Sex-Specific Targets For Better-Tailored Treatments -- Intersection of sex and depression: pathogenesis, presentation and treatments -- Biological and clinical implications of sex-specific differences in Alzheimer’s disease -- Part 3 Diabetes, metabolic diseases & cardiovascular risk -- Gender Differences In Cardiovascular Health: Hormonal Effects on Cardiovscular Risk And Management. - Sex Differences in Glucose Homeostasis -- Sex-gender-based differences in metabolic diseases -- Hypothalamic pituitary gonadal axis disorders impacting fertility in both sexes and the potential of kisspeptin-based therapies to treat them.
    Abstract: Biological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031426483
    Series Statement: Handbook of Experimental Pharmacology, 282
    DDC: 615
    Language: English
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  • 40
    Keywords: Neurosciences. ; Neurology . ; Neurophysiology. ; Neuropharmacology. ; Neuroscience. ; Neurology. ; Neurophysiology. ; Neuropharmacology.
    Description / Table of Contents: Molecular Biomarkers.Somatic instability/Telomeres,- Genetic modifiers -- Current clinical trial biomarkers.-Pharmacodynamic biomarkers for Htt-lowering therapeutics.-Inflammatory biomarkers.-Sleep dysregulation markers.-Mitochondrial/Oxidative stress biomarkers.-Microbiomics -- Metabolomics.-Proteomics.-Transcriptomics.-Lipidomics.-Imaging marker overview.-Retinal imaging biomarkers -- MRI - non-invasive functional MRI measures -- The evolution of clinical trial methodology.-Digital biomarkers -- The future of telehealth -- Summary and future trends.
    Abstract: Huntington’s disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents a distinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.
    Type of Medium: Online Resource
    Pages: XVI, 475 p. 42 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031328152
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Stem cells. ; Neurosciences. ; Neurology . ; Stem Cell Biology. ; Neuroscience. ; Neurology.
    Description / Table of Contents: Chapter 1: General Introduction -- Chapter 2: Clinical-grade stem cells for the treatment of neurodegenerative diseases -- Chapter 3: Stem cell treatment for Parkinson's disease -- Chapter 4: Stem cell treatment for Alzheimer's disease -- Chapter 5: Stem cell treatment for Huntington’s disease -- Chapter 6: Stem cell treatment for amyotrophic sclerosis disease -- Chapter 7: Stem cell treatment for multiple sclerosis -- Chapter 8: Stem cell treatment for muscular dystrophy -- Chapter 9: Stem cell treatment for spinal muscular atrophy -- Chapter 10: Stem cell treatment for Retinal Degeneration -- Chapter 11: Conclusion and future perspective.
    Abstract: This book reviews the state-of-the-art in stem-cell-based therapies for neurodegenerative diseases, and highlights advances in both animal models and clinical trials. It comprehensively discusses most neurodegenerative diseases, including such as Parkinson's, Alzheimer's and Huntington’s diseases, amyotrophic sclerosis, multiple sclerosis, muscular dystrophy and retinal degeneration, in which stem cells could potentially be used for therapy in the future. It also addresses the challenges and problems relating to the translation of stem-cell-based therapies into treatments. As such, the book will appeal to research scientists, physicians, graduate students, and medical professionals in the field of stem cells, neuroscience, neurology, neurorestoratology and major neurological disorders.
    Type of Medium: Online Resource
    Pages: V, 145 p. 20 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811543708
    Series Statement: Advances in Experimental Medicine and Biology, 1266
    DDC: 571.6
    Language: English
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  • 42
    Keywords: Biotechnology. ; Neurology . ; Biomedical engineering. ; Biotechnology. ; Neurology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Section A Physiology -- An Overview On Sleep Medicine -- Covering The Gap Between Sleep And Cognition – Mechanisms and Clinical Examples -- Obstructive sleep apnoea: Focus on Pathophysiology -- Diagnosis of obstructive sleep apnea in patients with associated comorbidity -- Pediatric Obstructive Sleep Apnea: What’s in a Name? -- Treatment of Cheyne-Stokes respiration in heart failure with adaptive servo-ventilation: An integrative model -- Section B Diagnostic innovations -- Automated scoring of sleep and associated events -- Conventional machine-learning methods applied to the automatic diagnosis of sleep apnea -- Home Sleep Testing of Sleep Apnea -- ECG and heart rate variability in sleep-related breathing disorders -- Cardiopulmonary Coupling -- Pulse oximetry: the working principle, signal formation, and applications -- Oximetry indices in the management of sleep apnea: from overnight minimum saturation to the novel hypoxemia measures -- Airflow Analysis In The Context OF Sleep Apnea -- Deep-learning Model Based on Convolutional Neural Networks to Classify Apnea-hypopnea Events From The Oximetry Signal -- Tracheal sound analysis -- Obstructive Sleep Apnea with COVID-19 -- Section C Therapeutic innovations -- APAP, BPAP, CPAP and new modes of positive airway pressure therapy -- Adherence monitoring using telemonitoring techniques -- Innovations in The Treatment of Pediatric Obstructive Sleep Apnea -- Hypoglossal Nerve Stimulation Therapy -- Anna M. Mohammadieh -- Index.
    Abstract: The book focuses on biomedical innovations related to the diagnosis and treatment of sleep apnea. The latest diagnostic tools are described, including sleep laboratory equipment, wearables, and even smartphone apps. Innovative medical devices for treatment are also covered, such as CPAP, Auto-PAP, hypoglossal nerve stimulation, phrenic nerve stimulation, acoustic brain stimulation and electrical brain stimulation. This is an ideal book for biomedical engineers, pneumologists, neurologists, cardiologists, physiologists, ENT physicians, pediatrics, and epidemiologists who are interested in learning about the latest technologies in treating and diagnosing sleep apnea. Chapter 12 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XI, 389 p. 68 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031064135
    Series Statement: Advances in Experimental Medicine and Biology, 1384
    DDC: 660.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Surgery. ; Neurology . ; Radiology. ; Pediatrics. ; Neurosurgery. ; Neurology. ; Radiology. ; Pediatrics.
    Description / Table of Contents: I Overview -- 1 Historical landmarks in pineal region surgery -- 2 Pineal region anatomy -- 3 Pathology of Pineal Region Lesions -- 4 Clinical presentation -- 5 Imagistic diagnosis -- 6 The Usefulness of Biomarkers for Diagnosis -- 7 Surgical Adjuvants for pineal region approach -- II Surgical approaches for pineal region lesions -- 8 Supracerebellar infratentorial approach -- 9 Occipital transtentorial approach -- 10 Transcallosal approach -- 11 Endoscopic approaches for pineal region lesions -- 12 Management of Hydrocephalus -- III Adjuvant therapies -- 13 Radiosurgery -- 14 Other radiotherapeutic techniques -- 15 Chemotherapy -- IV Pineal region tumors -- 16 Tumors of Pineal Cell Origin -- 17 Tumors of germ cell origin -- 18 Tumors of glial origin -- 19 Meningiomas of the pineal region -- 20 Metastatic tumors -- V Vascular lesions of the pineal region -- 21 Arterio-venous malformations -- 22 Cavernomas.-23 Vein of Galen Aneurismal Malformation -- VI Cysts and Cyst -Like Lesions of the pineal region -- 24 Epidermoids and Dermoids -- 25 Pineal Cyst -- VII Miscellanea -- 26 Management algorithms -- 27 Conclusions.
    Abstract: Neurosurgical lesions of the pineal region are extremely rare, accounting for roughly 1% of the total number of neurosurgical expansive lesions in modern practice. This book offers an up-to-date review of the relevant literature, combined with the personal perspectives of some highly experienced figures in the field. The book is divided into two main parts, the first of which offers an overview of the pineal region from an anatomic, pathologic, imaging and therapeutic perspective. Special attention is given to surgical approaches to pineal region lesions. Microsurgical techniques are presented, together with detailed indications regarding specific locations of these lesions, specific complications, and controversial aspects concerning some of the approaches. A dedicated chapter addresses endoscopic techniques, their indications and limitations. Adjuvant therapies are also discussed, along with their particular indications and debated aspects. In turn, the chapters in the second part cover specific lesions such as pineal region tumors, vascular lesions, and cystic and cyst-like lesions. Regarding pineal region tumors, the most frequent pathologies are presented in the most comprehensive and practical manner possible, with special attention to the appropriate therapeutic management for each type. Further, there is a dedicated chapter on pineal region cysts. Given its depth of content, the book will allow neurosurgeons and specialists to greatly expand their understanding of pineal region lesions in daily clinical practice.
    Type of Medium: Online Resource
    Pages: XI, 260 p. 113 illus., 82 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030509132
    DDC: 617.48
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Neurosciences. ; Human physiology. ; Neurology . ; Neuroscience. ; Human Physiology. ; Neurology.
    Description / Table of Contents: Chapter 1. Neurophysiology of Heart -- Chapter 2. Physiology of Cardiovascular System -- Chapter 3. THE Brain-Heart Crosstalk. .
    Abstract: This book discusses the underlying mechanisms connecting the brain and heart. The physiology of the brain is such that it is easily affected by any altered physiology of other systems, which in turn may compromise cerebral blood flow and oxygenation. Together, the brain and heart control our body systems, allowing them to function automatically. This interaction between the brain and other systems makes it important for us to understand how any kind of injury to the brain can produce complications in remote organs or systems, such as the heart. The central nervous system is responsible for vegetative function and is central to homeostasis. Further, central nervous system responses are linked to the ongoing function of other organ systems e.g. feeding, thermoregulation, reproduction and muscle activity. It is therefore logical that neural control of the cardiovascular system must also interact with the neural control of other organ systems. This book explains in detail stressed cardiac conditions, discussing the pathophysiology and proposed treatment, and also describing lesser-known crosstalks between the acutely or chronically affected brain and heart. .
    Type of Medium: Online Resource
    Pages: XIII, 130 p. 35 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811524974
    Series Statement: Physiology in Clinical Neurosciences – Brain and Spinal Cord Crosstalks,
    DDC: 612.8
    Language: English
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    Keywords: Nervous system Surgery. ; Neurology . ; Neurosciences. ; Neurosurgery. ; Neurology. ; Neuroscience.
    Description / Table of Contents: Chapter 1 Embryology of the Pineal Gland -- Chapter 2 Anatomy of the Pineal Gland -- Chapter 3 Physiology of the Pineal Gland -- Chapter 4 Neuroimaging of the Pineal Gland -- Chapter 5 Tumors of the Pineal Gland -- Chapter 6 Non-tumorous Lesions of the Pineal Gland -- Chapter 7 Treatment and Approaches for the Pineal Gland Region -- Chapter 8 Interesting Cases of Pineal Gland Diseases and Surgery -- Chapter 9 Animal Based Surgical Training in Pineal Approaches -- Chapter 10 Evolutionary Retrace of the Third Eye.
    Abstract: This comprehensive book focuses on neurosurgical aspects of the pineal gland. By covering virtually all aspects of the pineal gland, it fills an important gap in the neurosurgical literature. Further, it approaches this vital component of the human brain from various angles: embryology, anatomy, physiology, pathology, radiology and surgical techniques. More than 70 single-best-answer multiple-choice questions (MCQs) are distributed throughout the chapters. Offering an essential review for residents and surgeons across neurosurgical disciplines and containing most of the critical information needed to prepare for both the primary and certification exam, the book will also be of interest to neurologists, neuroscientists and medical students. .
    Type of Medium: Online Resource
    Pages: XXVIII, 141 p. 42 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030531911
    DDC: 617.48
    Language: English
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    Keywords: Neurosciences. ; Food science. ; Biology. ; Physiology. ; Therapeutics. ; Neurology . ; Neuroscience. ; Food Science. ; Biological Sciences. ; Physiology. ; Therapeutics. ; Neurology.
    Description / Table of Contents: Chapter 1. Aging and Neurodegeneration- A preface -- Chapter 2. Deciphering the molecular and genetic basis of Alzheimer’s disease -- Chapter 3. Tracking Neurodegeneration: Advancement in experimental study models -- Chapter 4. Pharmcological application of Phyllanthus emblica as therapeutics in Alzheimer’s disease -- Chapter 5. ROLE OF THE GUT MICROBIOME AND ITS MODULATION IN NEURODEGENERATIVE DISEASES -- Chapter 6. Recent advances in application of dietary polyphenols to treat age-related neurological disorders -- Chapter 7. PROPHYLAXIS THROUGH MARINE DERIVED BIOACTIVE COMPOUNDS TOWARDS NEURODEGENERATIVE DISORDERS -- Chapter 8. Recent advancements in omega fatty acids to treat neurodegeneration -- Chapter 9. Role of Alkoxyglycerol to Pause Tau Induced Alzheimer’s Disease -- Chapter 10. Application and Efficacy of Nano particle-based therapy Among Neurodegenerative Diseases -- Chapter 11. In silico techniques- Powerful tool for the development of therapeutics -- Chapter 12. Biomarkers: Potential perspectives in detection, diagnosis and prognosis of neurodegenerative disorders.
    Abstract: This book provides a comprehensive summary of the latest knowledge regarding functional foods and new therapeutic strategies for neurodegenerative disorders through explaining specific mechanisms for natural remedies and functional foods as well as alternative treatment and supplementary approaches for neurodegenerative diseases. Many relevant topics are covered, including role of prebiotics, recent applications for dietary polyphenols, marine bioactive compounds for neuro disorders, and age-related disorders. The roles of various remedies and functional foods are explained for various types of diseases, and the book also integrates the role of functional foods and remedies to work with the current therapeutics that are taking place. In parallel, the information presented through this book will also stimulate current status of leading contemporary methods for prohylactic and diagnostic practices, comprising nanoparticles, biomarkers, in silico techniques, and CRISPR-mediated genome editing–based therapy. The book will be essential reading for students and researchers with an interest in natural medicine, drug development, and food therapeutic strategies. In presenting new results and approaches and identifying areas for future research, it will also be of benefit for specialists in the field.
    Type of Medium: Online Resource
    Pages: XVI, 222 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811667039
    DDC: 612.8
    Language: English
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  • 47
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neurology . ; Nanowires. ; Neuropharmacology. ; Neuroscience. ; Neurology. ; Nanowires. ; Neuropharmacology.
    Description / Table of Contents: Section I: Neurodegenerative diseases -- Chapter 1: Nanowired delivery of cerebrolysin together with antibodies to amyloid beta peptide, phosphorylated tau and tumor necrosis factor alpha induces superior neuroprotection in Alzheimer's disease brain pathology exacerbated by sleep deprivation -- Chapter 2: Nanodelivery of histamine H3/H4 receptor modulators BF2649 and clobenpropit with antibodies to amyloid beta peptide in combination with alpha synuclein reduces brain pathology in Parkinson's disease -- Chapter 3: Co-administration of nanowired DL-3-n-butylphthalide (DL-NBP) together with mesenchymal stem cells, monoclonal antibodies to alpha synuclein and TDP-43 (TAR DNA-binding protein 43) enhance superior neuroprotection in Parkinson's disease following concussive head injury -- Chapter 4: Neuroprotective effects of nanowired delivery of cerebrolysin with mesenchymal stem cells and monoclonal antibodies to neuronal nitric oxide synthase in brain pathology following Alzheimer’s disease exacerbated by concussive head injury -- Section II: Central Nervous system Trauma -- Chapter 5: Co-administration of nanowired monoclonal antibodies to inducible nitric oxide synthase and tumor necrosis factor-alpha together with antioxidant H-290/51 reduces SiO2-nanoparticles induced exacerbation of pathophysiology of spinal cord trauma -- Chapter 6: Nanowired delivery of cerebrolysin with mesenchymal stem cells attenuates heat stress induced exacerbation of neuropathology following brain blast injury -- Chapter 7: Co-administration of nanowired oxiracetam and neprilysin with monoclonal antibodies to amyloid beta peptide and p-tau thwarted exacerbation of brain pathology in concussive head injury at hot environment -- Section III. Stress and Drugs of abuse -- Chapter 8: Nanowired delivery of mesenchymal stem cells with antioxidant compound H-290/51 reduces exacerbation of methamphetamine neurotoxicity in hot environment -- Chapter 9: TiO2-nanowired delivery of Chinese extract of Gingko biloba EGb-761 and bilobalide BN-52021 enhanced neuroprotective effects of cerebrolysin following spinal cord injury at cold environment -- Chapter 10: Nanowired delivery of curcumin attenuates methamphetamine neurotoxicity and elevates levels of dopamine and brain derived neurotrophic factor.
    Abstract: This book covers the use of nanomedicine in the delivery of neuroprotective agents, including pharmacological drugs, stem cells, neurotrophic factors, monoclonal antibodies and enzymes to induce greater beneficial effects in neurologic diseases. Thus, the main purpose of the book is to explore the delivery of drugs either alone or in combination with stem cells to enhance neuroprotection in neurological diseases. Brain pathology associated with acute trauma such as head injury and brain blast injury can also be managed using novel treatment strategies. In addition, emphasis is made that standard patterns of brain pathology may be complicated with multiple comorbidity factors where one agent alone is not sufficient to induce brain protection. Enzymes and antibodies may help in combination and enhance the efficacy when administered through nanotechnology. Progress in Nanomedicine in Neurologic Diseases will encourage further research in the field of neuroprotection, brain injury, neurodegenerative diseases, neuropharmacology, neuropathology, and neurology. Students and researchers along with policy makers, teachers and health care professionals may also benefit from the findings of the book for enhanced patients care.
    Type of Medium: Online Resource
    Pages: XV, 418 p. 40 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031329975
    Series Statement: Advances in Neurobiology, 32
    DDC: 612.8
    Language: English
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  • 48
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Neurosciences. ; Neurology . ; Pain medicine. ; Pharmacology. ; Neuroscience. ; Neurology. ; Pain Medicine.
    Description / Table of Contents: Part I. Social aspects of opioid use -- Chapter 1: A brief history of opioids and the evolution of concepts associated with substance use disorders -- Chapter 2: The two sides of opioid use: Unmet needs of opioids for pain management and the role of opioids in substance use disorders -- Chapter 3: Opioid markets and special populations -- Chapter 4: Towards a new drug policy agreement -- Chapter 5: The opioid crises -- Chapter 6: Persons who misuse opioids -- Chapter 7: The need for structural interventions for persons who misuse opioids -- Part II. Pharmacological and medical aspects of opioid use -- Chapter 8: Opioid effects and classification -- Chapter 9: Opioid receptors and neuronal signal transduction -- Chapter 10: Opioids in Pain -- Chapter 11: Opioids in Palliative Care -- Chapter 12: Opioids and the immune system -- Chapter 13: Opioid dependence, tolerance, and withdrawal -- Chapter 14: Medication-Assisted Treatment (MAT) 1: Opioid substitution therapy -- Chapter 15: Medication-Assisted Treatment for Opioid Use Disorders 2. Detoxification -- Chapter 16: Synthetic Opioids as New Psychoactive Substances (NPS).
    Abstract: Opioids are the mainstay in pain treatment and can be invaluable medications in palliative care. However, they are also responsible for the vast majority of preventable deaths related to drug use. This book presents an overview of the social and pharmacological aspects of opioid effects, aiming to provide researchers and health professionals with a firm understanding of their effects and mechanisms of action. The first section reviews the history of opioids from ancient civilizations to the current opioid crisis, gives voice to opioid users through first-hand testimonies, analyzes the existing international drug treatment agreements, and presents structured interventions for persons who misuse opioids. The second section covers state-of-the-art advances in the medical use of opioids, opioid-induced signal transduction, opioids in pain management, opioid use disorders and their treatment. It also presents an updated view of opioids as regulators of inflammation and host defense against pathogens and damage. The overall aim of this book is to provide the reader with a deeper knowledge of this field despite the complexities associated with the existence of numerous ligands, receptor subtypes, and complex pharmacological profiles. To this end, the chapter authors are specialists in the field who also have extensive experience in teaching, hoping to lend their expertise in translating complex concepts into comprehensive and clear explanations.
    Type of Medium: Online Resource
    Pages: XV, 387 p. 36 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031099366
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Medical care. ; Therapeutics. ; Neurology . ; Medicine Research. ; Biology Research. ; Pharmacology. ; Health Care. ; Therapeutics. ; Neurology. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. A Complete Patent Analysis of Cannabis/Marijuana in Drug Delivery and Disease Conditions -- Chapter 2. Neuropharmacological Approaches to Modulate Cannabinoid Neurotransmission -- Chapter 3. Cannabinoids in Cancer: Cross-talk Between Cannabinoids and miRNAs -- Chapter 4. Cannabis As A Potent Therapeutic Agent For Pharmaceutical Drugs: Recent Advancement In Drug Discovery And Human Healthcare -- Chapter 5. Cannabinoid-Based Innovative Prophylactic and Therapeutic Interventions for Neuropathic Pain and Migraine -- Chapter 6. The Legality of Use and Consumption of Cannabis (Marijuana) in the United States of America -- Chapter 7. Cannabis in Healthcare: Ethnobotanical and Pharmaceutical Perspectives and Legal Status in Turkey and The Middle East -- Chapter 8. Understanding the Pharmacokinetics, Safety Profile, and Scope of the Concerned Issue to Evade the Consumption of Cannabis/Marijuana -- Chapter 9. Traditional Uses of Cannabis in The Middle East and The Pathway to Cannabis-Based Healthcare in Israel -- Chapter 10. Traditional and Modern Health Uses of Cannabis sativa L. in Africa and its Phytochemical and Pharmacological Profile -- Chapter 11. Traditional Claims on Cannabis: An Indian and Global Scenario -- Chapter 12. Cannabis (Bhanga) in Classical Text of Ayurveda: An Evidence-Based Rationale -- Chapter 13. Cannabis-Based Cosmetic Products and Their Uses -- Chapter 14. Cannabis as A Unique and Valuable Nutraceutical Formulation for the Current and Future Global Wellbeing -- Chapter 15. Traditional, Cultural, and Nutraceutical Aspects of Cannabis in India.
    Abstract: The book contains review articles providing a comprehensive overview of cannabis/marijuana’s diverse healing aspects in human healthcare (medicinal, nutraceutical, skincare, etc.). The research articles include the role of cannabis in cancer treatment, drug discovery, cosmeceutical potential, prophylactic and therapeutic use for treating neuropathic pain and migraine, pharmacokinetics, safety profile, and issues related to the consumption of cannabis/marijuana.Another salient feature of the book is a complete mapping and region- and sector-wise critical analysis of cannabis/marijuana patents on healthcare and future directions for the benefit of researchers and businesses/entrepreneurs interested in the rapidly advancing area of cannabis. The text describes cannabis/marijuana’s detailed legal aspects, production prospects, and applications for healthcare and recreational purposes in the USA. It traces the traditional roots of cannabis use in Turkey, Israel, the Middle East, Africa, and India. This unique compendium of articles will be useful as a reference book for students, researchers, academics, business houses, and all individuals interested in medicinal, nutraceutical, cosmeceutical, traditional, legal, and commercial aspects of cannabis usage.
    Type of Medium: Online Resource
    Pages: XIX, 319 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811688225
    DDC: 615
    Language: English
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    Keywords: Developmental neurobiology. ; Neuroanatomy. ; Nervous system Diseases. ; Neurosciences. ; Neurology . ; Development of the Nervous System. ; Neuroanatomy. ; Neurological Disorders. ; Neuroscience. ; Neurology.
    Description / Table of Contents: Overview of the Development of the Human Brain and Spinal Cord -- Mechanisms of Development -- Causes of Congenital Malformations -- Neurulation and Neurulation Defects -- The Neural Crest and Craniofacial Malformations -- Development and Developmental Disorders of the Spinal Cord -- Development and Developmental Disorders of the Brain Stem -- Development and Developmental Disorders of the Human Cerebellum -- Development and Developmental Disorders of the Forebrain -- Development and Developmental Disorders of the Cerebral Cortex.
    Abstract: This book provides a comprehensive overview of the development of the human central nervous system (CNS) in the context of its many developmental disorders due to genetic, environmental and hypoxic/ischaemic causes. The book contains three general, introductory chapters in which an overview of the development of the human brain and spinal cord, a summary of mechanisms of development as obtained in experimental studies in various invertebrates and vertebrates, and an overview of the causes of congenital malformations are presented. The developmental disorders of the human brain and spinal cord are presented in a regional, more or less segmental way, starting with neurulation and neural tube defects, and ending with developmental disorders of the cerebral cortex. These chapters are abundantly illustrated in colour with carefully chosen clinical case studies with imaging data, and when available, postmortem verification of the developmental disorders involved. In the third edition, more emphasis has been given to the developmental ontology based on the prosomeric approach, and fetal development. Prenatal diagnosis by ultrasound, MRI and DTI, and classifications of developmental disorders have been updated. A number of new Clinical Cases have been included. Several new co-authors participate in various chapters. The book is intended for advanced medical students, and all those clinicians working with children and adults with developmental disorders of the CNS. Unique to the book is the integration of data from human embryology, experimental and molecular findings in mice in particular, imaging and developmental neuropathology.
    Type of Medium: Online Resource
    Pages: XVI, 916 p. 606 illus., 176 illus. in color. , online resource.
    Edition: 3rd ed. 2023.
    ISBN: 9783031260988
    DDC: 573.838
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical sciences. ; Neurology . ; Physical therapy. ; Health Sciences. ; Neurology. ; Physiotherapy.
    Description / Table of Contents: PART 1 -- 1. Neural basis of spasticity -- 2. Spasticity vs Spastic Movement Disorder -- 3. Clinical Assessment of the Syndrome of Spastic Paresis -- 4. Quantitative Measurement of Resistance to Passive Joint Motion in Chronic Stroke Survivors -- 5. Structural alterations in Spastic Muscle -- 6. Mechanisms of Development of Passive Mechanical Muscle Stiffness -- 7. Symptomatic and Functional After-Effects of the Syndrome of Spastic Paresis -- PART 2 -- 8. Framework for the Treatment of Spasticity and Muscle Stiffness -- 9. Medical Exacerbation of Spasticity -- 10. Oral Spasmolytics -- 11. Intrathecal Baclofen Therapy -- 12. Treatment of Focal Muscle Overactivity using Botulinum Toxin Injections -- 13. Treatment of Focal Muscle Stiffness with Hyaluronidase Injections -- 14. Emerging Non-pharmacologic Therapies.
    Abstract: This book aids the practitioner in understanding the difference between spasticity and muscle stiffness, weighing old and new treatment options, and developing an appropriate treatment algorithm for a given patient. Spasticity is a common and disabling condition after neurologic injury such as stroke, spinal cord injury, multiple sclerosis, traumatic brain injury and cerebral palsy. Current treatments for spasticity may exacerbate other problems. Hence, there is a great need to develop a comprehensive understanding of the pathophysiology of spasticity and muscle stiffness, its assessment, and the various treatment options available to obtain the best results to restore joint alignment, movement, and function. This book is organized into two sections: Part I of the book deals with the pathophysiology and assessment of spasticity and muscle stiffness, and Part II of the book explains the rationale, framework, considerations, and evidence for various treatments for both spasticity and muscle stiffness. This comprehensive approach will enable physiatrists, neurologists, internists, and physical and occupational therapists to achieve the best possible outcomes for their patients.
    Type of Medium: Online Resource
    Pages: XIX, 321 p. 111 illus., 105 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030969004
    DDC: 610
    Language: English
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    Keywords: Neurosciences. ; Pharmacology. ; Medicine Research. ; Biology Research. ; Neuropsychology. ; Neurology . ; Neuroscience. ; Pharmacology. ; Biomedical Research. ; Neuropsychology. ; Neurology.
    Description / Table of Contents: 1.Determination of ketamine in the river of China -- 2.Ketamine abuse in Taiwan -- 3.Ketamine problem in Hong Kong -- 4. Hair analysis of ketamine -- 5. Brain imaging of ketamine abusers -- 6.Management of complications of ketamine abuse -- 7.Action site of ketamine in the NMDA receptor channel -- 8.Synaptic modulation in the effect of ketamine -- 9.Rodents whole-brain imaging in the effects of ketamine -- 10. Behavioral pharmacology of ketamine: An overview of preclinical studies -- 11.Antidepressant potential of ketamine enantiomers -- 12.Effects of ketamine on pain-related depression -- 13.Role of gut microbiota in the antidepressant actions of ketamine and its enantiomers -- 14. The role of NMDA receptor GluN2D subunit in the effects of ketamine and enantiomers -- 15.Roles of the lateral habenula in the actions of ketamine -- 16.Comparison of antidepressant action of ketamine and group II mGlu receptor antagonists -- 17.Antidepressant effects of ketamine in Taiwanese patients with treatment-resistant depression.
    Abstract: This book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the serious problem of ketamine abuse. The first part of the book focuses on the evidence regarding ketamine abuse, with specific reference to Asian countries, and discusses countermeasures and complication management. It then addresses the mechanisms underlying the antidepressant and side effects of ketamine, which have remained elusive, describing and discussing important new research findings. Further, it explains insights gained from whole brain imaging in rodents and from behavioral pharmacology, and presents evidence regarding the role of gut microbiota, the NMDA receptor GluN2D subunit, and the lateral habenula in the actions of ketamine. These advances form the basis for the safer use of ketamine in patients with treatment-resistant depression and are expected to lead to the development of new antidepressants. .
    Type of Medium: Online Resource
    Pages: V, 189 p. 27 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811529023
    DDC: 612.8
    Language: English
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    Keywords: Nervous system Surgery. ; Nervous system Radiography. ; Oncology. ; Medical physics. ; Neurology . ; Interventional radiology. ; Neurosurgery. ; Neuroradiology. ; Oncology. ; Medical Physics. ; Neurology. ; Interventional Radiology.
    Description / Table of Contents: Creating the Future -- CyberKnife Warfare in America: Battles at the Border Between Neurosurgery and Radiation Oncology -- The CyberKnife Robotic Radiosurgery System -- The Target Locating System for CyberKnife NeuroRadiosurgery -- Treatment Planning -- Small Field Dosimetry -- Quality Control -- Morphological Imaging -- Functional Imaging -- Diffusion Tensor Imaging (DTI) tractography -- Metabolic Imaging -- Radiobiology of Radiosurgery and Hypofractionated Treatments -- Organs at Risk (OAR) Tolerance in Hypofractionated Radiosurgery -- Brain Metastasis: Therapeutic, Diagnostic and Strategic Considerations -- Brain Metastasis: The Experience of the Burdenko Institute of Neurosurgery -- Multiple Brain Metastases -- Large Metastases and Tumor Bed -- Parasagittal and Convexity Meningiomas -- Skull Base Meningiomas -- High Grade Meningiomas and Hemagiopericytomas -- Perioptic Meningiomas -- Optic Nerve Sheath Meningiomas -- Vestibular Schwannomas -- Large Vestibular Schwannomas -- Pituitary Adenomas -- Craniopharyngiomas -- Malignant Gliomas -- Pilocytic Astrocytomas -- Pineal Tumors -- Reirradiation of Skull Base Tumors -- Chordomas and Chondrosarcomas -- Paragangliomas of Head and Neck -- Paragangliomas: a case series from Burdenko Institute -- Brainstem Tumors -- Uveal Melanoma -- Pediatric Radiosurgery -- Immunotherapy and Radiosurgery -- Spinal Metastases -- Reirradiation of Spinal Metastases -- Benign Spinal Tumors -- Intradural Spinal Lesions -- Cerebral Arteriovenous Malformations -- Large Arteriovenous Malformations -- Cerebral Cavernous Malformations -- Dural Arteriovenous Fistulas -- Cavernous Sinus Hemangiomas -- Trigeminal Neuralgia -- Movement Disorders -- Epilepsy -- Psychiatric/Behavioral Disorders. .
    Abstract: This book is a practical guide on image-guided robotic (CyberKnife®) radiosurgery of the brain and the spine. The volume introduces the radiosurgical community to the potential of image-guidance in the treatment of neurosurgical diseases including neuro-oncological, vascular and functional disorders. Principles of image-guided radiosurgery, including physics and radiobiology are considered. Each chapter provides a critical review of the literature and analyses of several aspects to offer an assessment of single and hypofractionated treatments. Based on the authors’ experience, tables or summaries presenting the treatment approaches and associated risks are included as well. Providing a practical guide to define the selection of dose, fractionation schemes, isodose line, margins, imaging, constraints to the structures at risk will support safe practice of neuroradiosurgery. This book aims to shed new light on the treatment of neoplastic and non-neoplastic diseases of the central nervous system using the CyberKnife® image-guided robotic radiosurgery system. It will be adopted by neurosurgery residents and neurosurgery consultants as well as residents in radiation oncology and radiation oncologists; medical physicists involved in radiosurgery procedures may also benefit from this book. .
    Type of Medium: Online Resource
    Pages: XVI, 588 p. 147 illus., 120 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030506681
    DDC: 617.48
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical sciences. ; Medicine. ; Nursing. ; Neurology . ; Dentistry. ; Health Sciences. ; Clinical Medicine. ; Nursing. ; Neurology. ; Dentistry.
    Description / Table of Contents: Preparing your job application -- Pre Interview visits and interview format -- Clinical skills at interview -- Clinical leadership in healthcare -- Team work in healthcare -- Communication in healthcare -- Conflict in the healthcare environment -- Patient safety and clinical governance -- Quality improvement and innovation -- Education and research -- Challenges and opportunities.
    Abstract: This short practical text uses a coaching approach to develop the reader’s interview skills. With increasing competition, doctors and healthcare professionals need to prepare well for success at interview. The author has successfully coached colleagues in the run-up to interviews using this approach. Readers will learn how to structure responses to reflect their personality, knowledge and experience. This approach encourages candidates to craft their responses in a compelling narrative that will help them stand out. Healthcare organisations are increasingly looking at assessment of values and behaviours as part of the recruitment process. This represents a shift from a more clinical competency-based approach and requires additional preparation for interview. This book will help coach clinicians to describe their own experience in this context. The author is a practicing clinician, coach and led development of a clinical leadership and quality improvement training program for doctors and dentists and training in the UK. This book is aimed at doctors and healthcare professionals in training positions and those moving to a new role.
    Type of Medium: Online Resource
    Pages: XV, 129 p. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031163210
    DDC: 610
    Language: English
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    Keywords: Medical sciences. ; Orthopedics. ; Neurology . ; Surgery. ; Radiology. ; Physical therapy. ; Health Sciences. ; Orthopaedics. ; Neurology. ; Surgery. ; Radiology. ; Physiotherapy.
    Description / Table of Contents: Epidemiology -- Genetics -- Pathological basis for classification (cytomolecular aspects) -- Clinical assessment -- Preoperative neurophysiological evaluation -- Ultrasound imaging -- MR Imaging -- Other imaging modalities (PET scan, CAT scan, etc) -- Indications and techniques for pre-operative biopsy -- Fundamental aspects of surgical techniques for resection -- Neurophysiological monitoring during surgery -- Complications after tumor resection -- Management of painful conditions associated with nerve tumors -- Indications for radio and chemotherapy in malignant tumors -- Schwannomas -- Neurofibromas -- Perineuriomas -- Non-neurogenic tumoral and pseudotumoral lesions -- MALIGNANT PERIPHERAL NERVE SHEATH TUMORS -- Management of brachial plexus tumors -- Management of lumbosacral plexus tumors -- Management of paraspinal nerve sheath tumors -- Peripheral nerve tumors in infancy and childhood: particular aspects -- Epidemiology of genetic diseases with peripheral nerve tumors -- General introduction to Neurofibromatosis -- Genetic aspects of Neurofibromatosis -- Clinical management & indications for surgery in Neurofibromatosis -- Plexiform tumors in Neurofibromatosis -- Management of MPNST in Neurofibromatosis -- Schwannomatosis. .
    Abstract: Tumors involving peripheral nerves may be extremely challenging lesions to diagnose and treat. In order to optimize their management, physicians should have a thorough knowledge of peripheral nerve anatomy and pathology (both gross and microscopic), as well as familiarity with microsurgical techniques and intraoperative neurophysiological recording. This compendium deals with all aspects of tumors affecting peripheral nerves, from diagnosis to treatment; the topics it addresses range from epidemiology, anatomy, physiology, pathology, and clinical diagnosis to electrophysiology, imaging, genetic/cytomolecular aspects. Surgical approaches, biopsies and resection of various benign, malignant and pseudo-tumoral lesions, plexus tumors (both brachial and lumbosacral), and adjunctive treatment modalities and pain-related issues are described in detail. The book is intended not only for neurosurgeons, hand surgeons, plastic and orthopedic surgeons new to the field, but also for seasoned specialists who wish to update their knowledge with new insights based on robust experimental and clinical material. In addition, it will be a helpful tool for general and oncological surgeons who are sometimes faced with the treatment of mass lesions that may be potential nerve tumors, and for all practitioners who are engaged in the arduous struggle to bring relief to patients affected by these lesions.
    Type of Medium: Online Resource
    Pages: XV, 382 p. 179 illus., 127 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030776336
    DDC: 610
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Cytology. ; Zoology. ; Neurology . ; Neuroscience. ; Cell Biology. ; Zoology. ; Neurology.
    Description / Table of Contents: The Architecture of the Presynaptic Release Site.-Cytomatrix Proteins in Presynaptic Terminal. - Multiple Modes of Fusion and Retrieval at the Calyx of Held Synapse -- Roles of SNARE Proteins in Synaptic Vesicle Fusion -- Calcium Sensors of Neurotransmitter Release. - Roles and Sources of Calcium in Synaptic Exocytosis -- Regulation of Presynaptic Calcium Channels -- Roles of mUnc13/UNC-13 and mUnc18/UNC-18 in Neurotransmitter Release. - The role of tomosyn in the regulation of neurotransmitter exocytosis. -Roles of complexins in Neurotransmitter Release. -Regulation of Neurotransmitter Release by AIPR-1/AIP and calstabins. - The Role of Potassium Channels in the Regulation of Neurotransmitter Release -- Roles of Neuropeptides in Synaptic Function. - Transsynaptic Regulation of Presynaptic Release Machinery in Central Synapses by Cell Adhesion Molecules. - Lipids and Secretory Vesicle Exocytosis -- Synaptic Vesicle Endocytosis.
    Abstract: Neurons communicate with each other by releasing neurotransmitters. This book provides comprehensive coverage of the molecular mechanisms involved in neurotransmitter release. The topics covered in the book range from the architecture and cytomatrix proteins of presynaptic sites, to the modes of synaptic vesicle exocytosis (full-collapse and kiss-and-run), and from the key molecules mediating synaptic vesicle fusion (SNAREs) to those that closely interact with them (UNC-13/Munc13, UNC-18/Munc18, tomosyn, and complexins). The book also delves into the calcium sensors of synaptic vesicle fusion (synaptotagmins and Doc2s), the sources of calcium that trigger synaptic exocytosis (voltage-gated calcium channels and ryanodine receptors), and the regulation of neurotransmitter release by potassium channels, cell adhesion molecules, lipids, aryl hydrocarbon receptor-interacting protein (AIP), presenilins, and calstabins. To aid in understanding and illustrate key concepts, the book includes sufficient background information and a wealth of illustrations and diagrams. The new edition includes major updates to previous chapters, as well as several new chapters that reflect the recent advances in the field. Comprehensive and cutting-edge, Molecular Mechanisms of Neurotransmitter Release, 2nd edition, is a valuable learning resource for neuroscience students and a solid reference for neuroscientists.
    Type of Medium: Online Resource
    Pages: XI, 401 p. 77 illus., 62 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031342295
    Series Statement: Advances in Neurobiology, 33
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Veterinary medicine. ; Neurology . ; Anatomy. ; Neuroscience. ; Veterinary Science. ; Neurology. ; Anatomy.
    Description / Table of Contents: Introduction -- Rodent Taxonomic and biological data -- Basic Neurohistology -- Basic Neuroanatomy/ Coverings of the CNS/ Cerebrospinal fluid system -- Microscopic anatomy of the mouse brain -- The mouse spinal cord -- The mouse brainstem -- The mouse cerebellum -- The mouse dorsal thalamus -- The mouse hypothalamus.-The mouse cerebral cortex.-The mouse hippocampus.-The mouse amygdala -- The mouse caudate putamen -- The mouse oflactory system -- The mouse circle of Willis.
    Abstract: This textbook describes the basic neuroanatomy of the laboratory mouse. The reader will be guided through the anatomy of the mouse nervous system with the help of abundant microphotographs and schemata. Learning objectives and summaries of key facts at the beginning of each chapter provide the reader with an overview on the most important information. As transgenic mice are one of the most widely used paradigms when it comes to modeling human diseases, a basic understanding of the neuroanatomy of the mouse is of considerable value for all students and researchers in the neurosciences and pharmacy, but also in human and veterinary medicine. Accordingly, the authors have included, whenever possible, comparisons of the murine and the human nervous system. The book is intended as a guide for all those who are about to embark on the structural, histochemical and functional phenotyping of the mouse’s central nervous system. It can serve as a practical handbook for students and early researchers, and as a reference book for neuroscience lectures and laboratories. .
    Type of Medium: Online Resource
    Pages: XI, 350 p. 269 illus., 241 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030198985
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical sciences. ; Surgery. ; Neurology . ; Radiology. ; Emergency medicine. ; Health Sciences. ; Surgery. ; Neurology. ; Radiology. ; Emergency Medicine. ; Health Sciences.
    Description / Table of Contents: I Scientific background -- 1 Epidemiology of traumatic brain injury (Including prevention strategies -- 2 Pathophysiology of traumatic brain injury -- 3 “Mechanics of brain tissue damage following trauma” -- 4 Neuroprotection in traumatic brain injury -- II Current clinical Practice -- 5 Prehospital and emergency department management -- 6 Monitoring the injured brain -- 7 Contemporary Medical management of traumatic brain injury: High income countries -- 8 Contemporary Surgical management of traumatic brain injury: High income countries -- 9 Contemporary management of traumatic brain injury: Low and middle income countries -- 10 Military management of traumatic brain injury -- 11 Rehabilitation and social reintegration following traumatic brain injury -- III Evidence -- 12 Predicting outcome following traumatic brain injury -- 13 Biomarkers in traumatic brain injury -- 14 Erythropoietin in the management of traumatic brain injury: Current evidence -- 15 Progesterone in the management of traumatic brain injury: Current evidence -- 16 Amantadine in the management of traumatic brain injury for Traumatic brain injury -- 17 Hypothermia in the management of traumatic brain injury: Current evidence -- 18 Decompressive craniectomy in the management of traumatic brain injury: Current evidence -- 19 Cranioplasty following traumatic brain injury -- 20 Thromboembolic prophylaxis -- 21 Comparative effectiveness research -- 22 Brain Death: Current evidence and guidelines -- 23 Introduction to ethical concepts -- 24 Ethical issues when making clinical decisions in paediatrics patients -- 25 Long term outcome following traumatic brain injury: ethical issues -- 26 Withholding and withdrawing care -- 27 Prolonged disorders of consciousness.
    Abstract: This book provides a comprehensive analysis of the contemporary management of all aspects of traumatic brain injury (TBI), combining the findings of several recent randomised controlled trials investigating the role of hypothermia, erythropoietin, intracranial pressure monitoring and decompressive craniectomy in the management of TBI. The book is divided into four sections: the first section covers the epidemiology of TBI, the changing global patterns of presentation, and the basic pathophysiology and classification, while the second discusses contemporary management of TBI, from pre-hospital care, emergency assessment, and medical and surgical management to rehabilitation and social reintegration. The third section then examines the evidence gained from recent clinical trials that have investigated the efficacy of management strategies involving intracranial pressure monitoring, multimodal monitoring, hypothermia, erythropoietin, thromboembolic prophylaxis and decompressive craniectomy. Lastly, the fourth section explores the ethical issues, both at the societal level and on an individual basis. Written by a broad range of experts, this book provides a valuable reference resource for neurosurgeons, intensivists, clinicians with ethical experience and pure bioethicists in their daily work.
    Type of Medium: Online Resource
    Pages: XIII, 355 p. 76 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030780753
    DDC: 610
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neurology . ; Anatomy. ; Neuroscience. ; Neurology. ; Anatomy.
    Description / Table of Contents: Overview of the Human Brain and Spinal Cord -- Vascularization of the Brain and Spinal Cord -- Notes on Techniques -- The Somatosensory System -- The Reticular Formation and the Neuromodulatory Systems -- The Cranial Nerves -- The Auditory System -- The Visual System -- Motor Systems -- The Cerebellum -- The Basal Ganglia -- The Autonomic Nervous System -- The Hypothalamus, the Preoptic Area and Hypothalamohypophysial Systems -- The Limbic System -- The Cerebral Cortex and Complex Cerebral Functions.
    Abstract: Connections define the functions of neurons: information flows along connections, as well as growth factors and viruses, and even neuronal death can progress through connections. Accordingly, knowing how the various parts of the brain are interconnected to form functional systems is a prerequisite for properly understanding data from all fields in the neurosciences. Clinical Neuroanatomy: Brain Circuitry and Its Disorders bridges the gap between neuroanatomy and clinical neurology. It focuses on human and primate data in the context of brain circuitry disorders, which are so common in neurological practice. In addition, numerous clinical cases are presented to demonstrate how normal brain circuitry can be interrupted, and what the effects are. Following an introduction to the organization and vascularization of the human brain and the techniques used to study brain circuitry, the main neurofunctional systems are discussed, including the somatosensory, auditory, visual, motor, autonomic and limbic systems, the cerebral cortex and complex cerebral functions. In this 2nd edition, apart from a general updating, many new illustrations have been added and more emphasis is placed on modern techniques such as diffusion magnetic resonance imaging (dMRI) and network analysis. Moreover, a developmental ontology based on the prosomeric model is applied, resulting in a more modern subdivision of the brain. The new edition of Clinical Neuroanatomy is primarily intended for neurologists, neuroradiologists and neuropathologists, as well as residents in these fields, but will also appeal to (neuro)anatomists and all those whose work involves human brain mapping.
    Type of Medium: Online Resource
    Pages: XVI, 981 p. 509 illus., 325 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030418786
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Surgery. ; Endoscopic surgery. ; Neurology . ; Neurosciences. ; Neurosurgery. ; Minimally Invasive Surgery. ; Neurology. ; Neuroscience.
    Description / Table of Contents: Part 1 Evolution of the Keyhole Concept: The MIN-Key Concept -- Recent Roots of MIN -- The Role of Ergonomics for MIN -- The Multimodal Key Techniques of MIN -- Laboratory Simulation and Training for MIN -- Laboratory Simulation and Training for MIN -- Scientific Preliminaries for MIN -- Part 2 Clinical Cases -- Subcortical Bleedings -- Ganglia Bleedings -- Ventricular Bleedings -- Deep Seated Parenchymal Bleedings -- Neuropsych Effective Bleedings -- Complex Cases -- Not Operated Cases -- Contraindications -- Extraparenchymal Bleeding Cases -- Future perspectives.
    Abstract: This is the first of four volumes that together elaborate on an advanced minimally invasive neurosurgery (MIN) technique for cerebral hemorrhages, which makes it possible to prevent secondary injury by the hematoma and to preserve neurological function and accelerate neuropsychological recovery after the evacuation. It describes in detail the theoretical, technical and training procedures necessary to carry out successful intracerebral hemorrhage evacuations using MIN techniques. A combination of mouth-tracked microsurgery, neuro-sonography, neuro-endoscopy, LASER and sealing makes highly effective, minimally invasive evacuation of all types of hematomas possible. The MIN Key Concept, an advanced new model based on the Keyhole Concept and MIN techniques is also presented. Lastly, the scientific basics of MIN are discussed and summarized. A historical curriculum vitae is included in memory of the main pioneer of innovative MIN techniques, Prof. Axel Perneczky, to whom this book is dedicated.
    Type of Medium: Online Resource
    Pages: XIX, 396 p. 470 illus., 464 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030465131
    Series Statement: Key-Concepts in MIN, 1
    DDC: 617.48
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Cancer. ; Immunology. ; Neurology . ; Cell Biology. ; Cancer Biology. ; Immunology. ; Neurology.
    Description / Table of Contents: A View of the Endoplasmic Reticulum Through the Calreticulin Lens -- Structural Analysis of Calreticulin, an Endoplasmic Reticulum-Resident Molecular Chaperone -- The Role of Endoplasmic Reticulum Chaperones in Protein Folding and Quality Control -- Proteins Interacting with STIM1 and Store-Operated Ca2+ Entry -- Endoplasmic Reticulum (ER) and ER-Phagy -- Defects in Protein Folding and/or Quality Control Cause Protein Aggregation in the Endoplasmic Reticulum -- Roles of Calreticulin in Protein Folding, Immunity, Calcium Signaling and Cell Transformation -- Impact of Calreticulin and Its Mutants on Endoplasmic Reticulum Function in Health and Disease -- Cancer Biology of the Endoplasmic Reticulum Lectin Chaperones Calreticulin, Calnexin and PDIA3/ERp57 -- Maintenance of Endoplasmic Reticulum Protein Homeostasis in Cancer: Friend or Foe -- IP3 Receptor Biology and Endoplasmic Reticulum Calcium Dynamics in Cancer -- Disruption of Endoplasmic Reticulum Proteostasis in Age-Related Nervous System Disorders -- Endoplasmic Reticulum Homeostasis and Stress Responses in Caenorhabditis elegans -- Tardigrada: An Emerging Animal Model to Study the Endoplasmic Reticulum Stress Response to Environmental Extremes. .
    Abstract: This book provides a comprehensive overview of the biology of the endoplasmic reticulum (ER) and the associated ER proteins, it discusses their structure, function and signaling mechanisms in the cell and their role in disease. This book also offers insights into the practical aspects of research and demonstrates the use of non-mammalian models to study the structure and function of the ER. Written by leading experts in the field, the book enables readers to gain a thorough understanding of current ER biology. It is intended for scientists and clinical researchers working on the endoplasmic reticulum in all its various roles and facets in health and disease. .
    Type of Medium: Online Resource
    Pages: VIII, 327 p. 27 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030676964
    Series Statement: Progress in Molecular and Subcellular Biology, 59
    DDC: 571.6
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Regeneration. ; Alternative medicine. ; Neurology . ; Regeneration and Repair in the Nervous System. ; Complementary and Alternative Medicine. ; Neurology.
    Description / Table of Contents: Histopathological Basis for Acupuncture -- Current Advances in Mathematical Models of Initial Response to Mechanical Stimulation at Acupoint -- Signal Transduction in Acupoints -- Cellular Mechanisms in Acupuncture Effects -- Chemical and Physical Characteristics of Moxibustion -- Imaging of Acupuncture’s Effects: From Bedside to Bench -- Meridians – Neurosensory Organs within the System of Homeostatic Regulation -- Meridian-Viscera Correlationship: Theory and Mechanism of the Heart Meridian-Heart-Brain Interactions -- Autonomic Function and Electroacupuncture -- Understanding of Myofasial Trigger Points: Acupuncture verses Dry Needling -- Current Research in Silver Needle Acupuncture for Myofascitis -- Acupuncture in Supportive Care for Breast Cancer Survivors -- Alternative Therapies for Chemotherapy-Induced Peripheral Neuropathy -- Acupuncture and Related Techniques for Perioperative Care of Surgical Patients -- Hypothalamic-pituitary-adrenal Axis: A Bridge between acupuncture and diseases -- Neurobiological Mechanism of Acupuncture Analgesia in Chronic Somatic Pain -- Analgesic Effects of Acupuncture on Orofacial Pain -- Itch and the Antipruritic Effect of Acupuncture -- Acupuncture for Autism Spectrum Disorders -- Acupuncture Treatment for Multiple Sclerosis -- The Clinical and Experimental Study on Acupuncture for Children with Cerebral Palsy -- Beneficial Effect of Acupuncture on Depressive Disorders -- Acupuncture and Alzheimer’s Disease -- Acupuncture Treatment for Alzheimer’s Disease -- Electroacupuncture against Ischemic Brain Injury: Efficacy, optimal conditions and Mechanisms.
    Abstract: Written by over seventy scientists and clinicians worldwide from China, USA, Germany, Canada, Japan and other countries, this monograph, with nearly 450 figures and tables, covers a wide range of advanced progress in acupuncture research, from experimental research to clinical applications. In addition to exploring the histopathological basis for acupuncture and mathematical simulation of acupoint response to stimulation, initiation and transduction of acupuncture signals and cellular mechanisms during acupuncture effects as well as chemical and physical characteristics of moxibustion on acupoints are broadly discussed. The topics also include novel data on acupuncture effect with advanced imaging techniques, a unique understanding of meridian-viscera correlation, specific interactions between meridians and neurosensory organs within the system of homeostatic regulation and the acupuncture-induced influences on autonomic function. Several chapters introduce specific approaches with dry needling, silver needling and stainless needling for certain diseases, such as myofascitis, supportive care for breast cancer and chemotherapy-induced peripheral neuropathy as well as perioperative care of surgical patients. Moreover, this book discusses recent research on acupuncture therapy and potential mechanisms for a number of severe and refractory neurological disorders, including hyperactivity of hypothalamic-pituitary-adrenal axis, orofacial pain, chronic pain, itch, multiple sclerosis, autism spectrum disorders, cerebral palsy, depressive disorders, Alzheimer’s disease and ischemic brain injury. The vast amount of information offered in this book provides a comprehensive perspective on advanced acupuncture research to not only acupuncturists, but also to neuroscientists, neurologists, and other clinicians. For medical students and graduate and undergraduate students majoring in biology, physiology and neuroscience, this book offers an advanced course in learning about the mechanism-driven advances in alternative and complementary medicine. * Contains a comprehensive summary of the latest advances in acupuncture research from all over the world * Provides an easy-to-navigate reference for acupuncture researchers and neuroscientists alike * Combines basic and clinical knowledge of acupuncture and explores the molecular and neurobiological mechanisms that underlie it.
    Type of Medium: Online Resource
    Pages: XXIX, 750 p. 423 illus., 362 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030962210
    DDC: 612.8
    Language: English
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  • 63
    Keywords: Neurosciences. ; Neurology . ; Nervous system Diseases. ; Cognitive neuroscience. ; Neurophysiology. ; Learning Physiological aspects. ; Memory Physiological aspects. ; Neuroscience. ; Neurology. ; Neurological Disorders. ; Cognitive Neuroscience. ; Neurophysiology. ; Learning and Memory.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. The Psychiatrist and Pathologist Aloysius Alzheimer and His Seminal Findings -- Chapter 3. Alzheimer’s Disease Research After 1945: The Recommencement -- Chapter 4. Alzheimer’s Research Goes Deeper – Ultrastructural Electron Microscopy Studies -- Chapter 5. Focus on Neurochemistry Led to the Cholinergic Hypothesis of Alzheimer’s Disease -- Chapter 6. The Glutamatergic-Hypothesis of Alzheimer’s Disease -- Chapter 7. Biochemistry and Genetics Points Out a Prime Suspect for Causing Alzheimer’s Disease -- Chapter 8. Getting to the Bottom of It: Amyloid Beta Peptide Is Derived from a Larger Precursor -- Chapter 9. Step by Step Towards an Amyloid Beta Peptide-Based Hypothesis of Alzheimer’s Disease -- Chapter 10. Concerns about the Amyloid Cascade Hypothesis and Reappraisals -- Chapter 11. Ignorance or Conspiracy? Or Just an Amyloid Firewall that Blocks Alternative Ideas? -- Chapter 12. In the Slip Stream of Amyloid: The Tau and Tangle Hypothesis -- Chapter 13. Focus on Tauopathies and Beyond -- Chapter 14. Alzheimer’s Research Gains Momentum and Spreads Out -- Chapter 15. The Amyloid Cascade Hypothesis Has to Deliver, Finally -- Chapter 16. Beyond APP, PSEN1, PSEN2, and APOE: What Else Does the Genome Tell Us? Chapter 17. Alternative Hypotheses and Observations that were Somehow Lost on the Way -- Chapter 18. Is the Persistence of the Amyloid Cascade Hypothesis a Result of Constant Confirmation Bias? -- Chapter 19. Driving Forces of Alzheimer’s Research Directions -- Chapter 20. Thirty Years after the Launch of the Amyloid Cascade Hypothesis: Is There a Shift of Gears at Last? -- Chapter 21. "If You Change the Way You Look at Things, Things You Look at Change".
    Abstract: This book highlights the key phases and central findings of Alzheimer’s Disease research since the introduction of the label ‘Alzheimer’s Disease’ in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer’s drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explain the pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed? In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer’s research community only more recently. With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer’s Disease research. The book is written for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who would like to gain a broad and beyond the surface insight into (the key developments of) one of the most promoted research fields of our time. With its extensive literature references and over 100 illustrations, the book is also attractive for students and interested lay persons. Elaborating on all the different aspects and research approaches of this research field, the author aims to convince the reader that the underlying causes of Alzheimer’s Disease may be much more complex than previously thought and that this must be considered for future research directions. While he hopes that the Alzheimer’s research community is finally ready to shed its ‘amyloid-straitjacket’ that has hampered progress for too long, he is also convinced that a much-needed paradigm shift can guide future Alzheimer’s Disease research and provide a new and broader perspective on this age-dependent brain disease.
    Type of Medium: Online Resource
    Pages: XXV, 652 p. 116 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031315701
    DDC: 612.8
    Language: English
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  • 64
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Neurosciences. ; Neurology . ; Cognitive psychology. ; Neuroscience. ; Neurology. ; Cognitive Psychology.
    Description / Table of Contents: The world of Brain: from Aging Brain, Diseased Brain to Social Brain -- Cognitive Aging:How the Brain Ages -- Cognitive Decline Associated with Aging -- The Overview of Cognitive Aging Model -- The Emotional and Affective Disorders in Cognitive Aging -- The Mechanism of Socioeconomic Status and Stress Effects on Cognition -- The Aging Patterns of Brain Structure, Function and Energy Metabolism -- Characteristics of Brain Network during Cognitive Aging -- Biomolecular Markers of Brain Aging -- Neurobiological Mechanisms of Cognitive Decline Caused by Brain Aging -- The Early Stage of Abnormal Aging: Cognitive Impairment -- The Terminal Stage of Abnormal Aging: Dementia -- The Effect of Cognitive Rehabilitation Training and Its Neuroimaging and Physiology Evidence -- Lifestyle Regulation and Its Evidence: Changes brought from Adjusting Correlative Factors of Cognitive Aging -- The Effect of Traditional Chinese Medicine on Delaying Age-related Cognitive Decline and Its Evidence.
    Abstract: This book reviews the research trends of cognitive aging and brain health from full-scale. It not only contains cognitive aging’s neurophysiological mechanism, clinical research and intervention measures, but also covers cognitive aging’s social psychological mechanism, such as the relation between old people’s motion, socioeconomic status and the cognitive aging. Through decades of research and practice, the views towards the cognitive aging process havebeen transferred from coping with cognitive decline to promoting cognitive ability. This book provides with the latest research findings and in-depth opinions of the cognitive aging and brain health, assisting researchers to grasp the theories, practice and trends of this field, and guide health-care workers to carry out the treatment and nursing for the aged.
    Type of Medium: Online Resource
    Pages: VIII, 194 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819916276
    Series Statement: Advances in Experimental Medicine and Biology, 1419
    DDC: 612.8
    Language: English
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  • 65
    Keywords: Artificial intelligence. ; Cognition. ; Consciousness. ; Intellect. ; Neurology. ; Philosophy of mind.
    Pages: xii, 184 p.
    Edition: Rev. ed., 9th printing
    ISBN: 0-585-31122-6
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