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  • 1
    Keywords: Medicine Research. ; Biology Research. ; Stem cells. ; Developmental biology. ; Biomedical Research. ; Stem Cell Biology. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Chapter 1. Hematopoietic Stem Cell Development in Mammalian Embryos -- Chapter 2. Hematopoietic Stem Cells and Their Bone Marrow Niches -- Chapter 3. Emerging Roles of Epigenetic Regulators in Maintaining Hematopoietic Stem Cell Homeostasis -- Chapter 4. Metabolism in Hematopoiesis and Its Malignancy -- Chapter 5. The Origin of Clonal Hematopoiesis and Its Implication in Human Diseases -- Chapter 6. Ex vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells -- Chapter 7. N6-methyladenosine RNA Modification in Normal and Malignant Hematopoiesis -- Chapter 8. Immune System Influence on Hematopoietic Stem Cells and Leukemia Development -- Chapter 9. Learning from Zebrafish Hematopoiesis -- Chapter 10. Multi-lineage Differentiation from Hematopoietic Stem Cells -- Chapter 11. Gene Editing in Hematopoietic Stem Cells -- Chapter 12. Aging, Causes and Rejuvenation of Hematopoietic Stem Cells.
    Abstract: This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic.
    Type of Medium: Online Resource
    Pages: XV, 210 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819974719
    Series Statement: Advances in Experimental Medicine and Biology, 1442
    DDC: 610.72
    Language: English
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  • 2
    Keywords: Geography. ; Ethnology. ; Culture. ; Human geography. ; Cultural geography. ; Geography. ; Regional Geography. ; Regional Cultural Studies. ; Social and Cultural Geography.
    Description / Table of Contents: Introduction -- The Physical Environment -- Biological Environment -- The First People -- People on the Landscape -- Making a Living -- Life at Home -- Conclusions.
    Abstract: For the past 9,000 years, people lived and flourished along the 1,000-mile Aleutian archipelago reaching from the American continent nearly to Asia. The Aleutian chain and surrounding waters supported 40,000 or more people before the Russians arrived. Despite the antiquity of continuous human occupation, the size of the area, and the fascinating and complex social organization, the region has received scant notice from the public. This volume provides a thorough review describing the varied cultures of the ancestral Unangax̂, using archaeological reports, articles, and unpublished data; documented Unangax̂ oral histories, and ethnohistories from early European and American visitors, assessed through the authors’ multi-decade experience working in the Aleutian Archipelago. Unangam Tanangin ilan Unangax̂/Aliguutax̂ Maqax̂singin ama Kadaangim Tanangin Anaĝix̂taqangis (Culture and Archaeology of the Ancestral Unangax̂/Aleut of the Aleutian Islands, Alaska) begins with a description of the physical and biological world (The Physical Environment and The Living Environment) of which the Unangax̂ are part, followed by a description of the archaeological research in the region (The People). The rest of the book addresses ancestral Unangax̂ life including settlement on the land, and the characteristics of sites based on the activities that took place there (People on the Landscape). From this broad perspective, the view narrows to the people making a living through hunting, fishing, and collecting food along the shore-line, making their intricate tools, storing and cooking food, and sewing and weaving (Making a Living); household life including house construction, households, and the work done within the home (Life at Home); and the personal changes an individual goes through from the time they are born through death, including spiritual transitions and ceremonies (Transitions), and the evidence for these events in the material record. This book is written in gratitude to the Unangax̂ and Aleut people for the opportunity to work in Unangam Tanangin or the Aleutian Islands, and to learn about your culture. We hope you find this book useful. The purpose of this book is to introduce the broader public to the cultures of this North Pacific archipelago in a single source, while simultaneously providing researchers a comprehensive synthesis of archaeology in the region.
    Type of Medium: Online Resource
    Pages: XXI, 419 p. 64 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031442940
    DDC: 910
    Language: English
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  • 3
    Keywords: Medicine Research. ; Biology Research. ; Regenerative medicine. ; Biomaterials. ; Biomedical Research. ; Regenerative Medicine and Tissue Engineering. ; Biomaterials.
    Description / Table of Contents: Chapter 1. An Introduction to Scaffolds, Biomaterial Surfaces, and Stem Cells -- Part I. Structural Scaffolds and Bio-activation -- Chapter 2. Polymeric and Biomimetic ECM Scaffolds for Tissue Engineering Applications -- Chapter 3. Versatile Hydrogels in Regenerative Medicine -- Chapter 4. Multilayer Microcapsules with Tailored Structures and Properties as Delivery Carriers for Drugs and Growth Factors -- Part II Biomaterials Surfaces/Interfaces and Bio-interactions. Chapter 5. Interactions of Biomaterial Surfaces with Proteins and Cells -- Chapter 6. Surface Modification of Tissue Engineering Scaffolds -- Chapter 7. Gradient Biomaterials and Their Impact on Cell Migration -- Chapter 8. Stem Cell Differentiation Mediated by Biomaterials/Surfaces -- Part III Regeneration of Some Clinic-Targeted Tissues -- Chapter 9. Cartilage Regeneration -- Chapter 10. Skin Regeneration -- Chapter 11. Regeneration of Blood Vessels -- Chapter 12. Cardiac repair and regeneration -- Chapter 13. Nerve Regeneration.
    Abstract: This book reviews state of the art of polymeric biomaterials for regenerative medicine and highlights advances in both fundamental science and clinical practice. It summarizes the latest techniques in polymeric scaffold fabrication, delivery carriers, physiochemical property modulation, as well as their influence on the adhesion and performance of biomolecules, cells, and tissues. It also describes methods for creating biofunctional surfaces/interfaces and subsequently modulating the host response to implantable materials. Lastly, it discusses the applications of biomaterials and constructs in soft-tissue regenerative medicine. It is a valuable resource for materials scientists and engineers wishing to identify research priorities to fulfill clinical needs and provides physicians with insights into emerging novel biomaterials. This integrated approach also offers engineering students a sense of the relevance of materials science in the development of novel therapeutic strategies. In the second edition, most of the chapters are updated according to the latest progress of this research field. A new chapter on nerve regeneration is also included.
    Type of Medium: Online Resource
    Pages: VIII, 577 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789819969487
    DDC: 610.72
    Language: English
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  • 4
    Keywords: Environmental geography. ; Human geography. ; Urban policy. ; Sociology, Urban. ; Integrated Geography. ; Human Geography. ; Urban Policy. ; Urban Sociology.
    Description / Table of Contents: Cramped spaces, w(r)iggle room and everyday politics: An introduction -- Part 1: Everyday geographies of scholar activism -- Should I stay or should I go? Academic tempered radicalism in the era of ecological crisis -- Towards ‘minor’ methodologies or crisis as method -- Part 2: Repertoires of research methodologies and fieldwork experiences -- The sympoietic orchard: Everyday ways of co-creating an orchard -- Researching urban coworking spaces: Everyday life and reflexivity during the fieldwork -- Beyond the club: A feminist poetic inquiry to reimagine festive spaces and practices of the electronic scene in Paris -- Mapping sifikile – A place of home: Methodological reflections on hope from a coal frontier -- Madame Ruetabaga’s prefigurative politics at the urban fringes of Grenoble -- Digital practices on social media: New perspectives on the production of space and geopolitical inquiry -- Part 3: Embodied negotiations: Agency, survival, care -- Life at the margins: Women’s everyday practices as resistance in a working-class neighbourhood in Barcelona -- Digitalisation of working space: Women working from home in Turkey -- Home, work and everyday life: Gender dynamics in a mining city -- Epilogue.
    Abstract: The book provides a critical analysis of the geographies of everyday life, looking at how spatial practices craft w(r)iggle room to cope with the boundaries saturated by normativity, power relations, and inequalities. It explores the possibilities for making do with the everyday practices forming a way of living in cramped spaces. In this respect, early-career researchers and activists share their fieldwork experiences through an intersectional lens based on emerging research methodologies and scholar-activist practices. From their own vantage point, they look at their own contexts, practices, and research subjects at the level of everyday life. Spatial practices and place-based imaginaries from France, Finland, and Spain to Turkey and South Africa present a wide range of non-counter hegemonic yet enabling practices for transformation in everyday life. The contributors, trained in a variety of convergent disciplines concerned with everyday life and space (geography, geopolitics, architecture, urban planning, sociology, political sciences), discuss scholar-activist methodologies during the current crisis in contemporary academia, reflect on their research methodologies and research experiences, and inquire into the ways of embodied negotiations for agency, survival, and care. A group of early-career researchers and activists came together to seek out the possibilities of transformative change in everyday life during the peak periods of COVID-19. When researchers and activists were forced to stay at home in isolation, the authors met up online to discuss their subjectivities self-reflexively to challenge the distance between the researcher and “the field.” The book is the outcome of their collective production based on numerous meetings, writing workshops, and creative debates.
    Type of Medium: Online Resource
    Pages: XIV, 224 p. 23 illus., 18 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031465802
    Series Statement: The Urban Book Series,
    DDC: 910
    Language: English
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  • 5
    Keywords: Geography. ; Sustainability. ; Economic geography. ; Globalization. ; Geography. ; Sustainability. ; Economic Geography. ; Globalization.
    Description / Table of Contents: Re-thinking cities and the urban: from the global to the local -- From the new world to multiple possible worlds: political geography, geopolitics and border studies -- New and emerging pathways for transport geography -- Geography and geographers in place and time: a view from the international geographical union’s commission on the history of geography -- Innovative development of modern agricultural geographic engineering -- Integrating Geography for Global Sustainability and the Earth's Future: the role of International Geographical Union Commission on Geography of Future Earth -- Global change and human mobility in the Anthropocene -- Contribution of Geography and Geospatial Technology to Cope with Hazards and Risks: Implications of GIS Development in Japan -- Marginality issues in a time of world reorganization -- Land Use and Land Cover Changes in a Global Environmental Change Context -- The Contribution of Geography -- Coastal Systems: the dynamic interface between land and sea -- Advances in karst geomoprhology and hydrogeology research in the last decade and its future direction for karst land use planning -- Achievements and challenges of geographical research in Africa -- Issues and dilemmas of local and regional development in geographical research.
    Abstract: This book identifies and discusses research directions, challenges and achievements in contemporary geography. It also documents the most current theoretical and methodological considerations undertaken by scientists representing various sub-disciplines of geography with particular reference to human geography. It was assumed that the thematic structure of the currently active International Geographical Union (IGU) problem commissions corresponds to the most relevant and current research directions in geography. Reflecting this assumption, the book consists of 14 chapters contributed by geographers representing 14 problem commissions of the IGU, which allows us to examine geography from different perspectives and to provide the reader with a complete overview of contemporary research issues in human geography. The first part discusses contemporary research problems and issues related to scientific methodology and achievements of selected geographical sub-disciplines, including urban geography, agricultural geography, transport geography, and political geography, among others. The second part focuses on the interdisciplinarity of geography and the topics of global dimension undertaken by geographers such as global change, GIS and geospatial technology, marginalization, and environmental change. This part also discusses the internal relations between geographical specializations and their links with other related sciences, including geology, sociology, and economics. The third part discusses the holistic approaches of geography applied to particular regions, territories, or conditions (Africa, costal systems, geomorphology and local development).
    Type of Medium: Online Resource
    Pages: XVI, 293 p. 40 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819966042
    Series Statement: Advances in Geographical and Environmental Sciences,
    DDC: 910
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Medicine Research. ; Biology Research. ; Anatomy. ; Information visualization. ; Biophysics. ; Biomedical Research. ; Anatomy. ; Data and Information Visualization. ; Bioanalysis and Bioimaging.
    Description / Table of Contents: Chapter 1. The Importance of Integrating the Visual Arts into the Medical Curriculum -- Chapter 2. Using Medical Illustration to Improve Understanding of Endometriosis -- Chapter 3. Editorial Medical and Scientific Illustration -- Chapter 4. Current Approaches in Narrative Medical Visualization -- Chapter 5. Animation for Science Communication: A Description of the Production Process and Contexts for Using Science Animation -- Chapter 6. Effect of the Rings: A Visual Story Design Comparing Three Chemical Characters -- Chapter 7. Diabetes Year One, Random Fluctuations and Mental Goblins: Auto-Ethnographic Pathographies and Medical Comics -- Chapter 8. Playing with Science: Games as a Medium of Science Communication -- Chapter 9. Increasing Microbiology Literacy about the Public Health Threat of Antimicrobial Resistance Through Art-Science Interactions -- Chapter 10. Collaged Creatures: Using Collage Art Practice and Posthuman Ethics to Discuss Bioengineering Hybrids.
    Abstract: This edited book explores the breadth of approaches undertaken by scientists, artists and communicators in their crucial role making science accessible, engaging and impactful. Contemporary approaches in science illustration and visualization include a variety of creative methodologies that are valuable for effective communication, teaching, learning and professional practice. These range in method from anatomical drawings used in medical curricula, to 2D animations and editorial illustrations available in the public realm. They also include unexpected approaches such as the use of tabletop board games, comics and collage in understanding our bodies, emergent health threats and cutting-edge science developments. If you are a scientist seeking to enhance your ability to communicate your research or an artist interested in biomedical visualization, this volume serves as an introduction to contemporary approaches in science illustration and communication. By understanding the creative methods and techniques employed in this field, we can collectively work towards fostering a deeper appreciation of art in science, and continue to captivate and inspire audiences worldwide. .
    Type of Medium: Online Resource
    Pages: XVI, 252 p. 158 illus., 140 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031416521
    Series Statement: Biomedical Visualization, 4
    DDC: 610.72
    Language: English
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  • 7
    Keywords: Environmental geography. ; Regional economics. ; Spatial economics. ; Political science. ; Political planning. ; Integrated Geography. ; Regional and Spatial Economics. ; Governance and Government. ; Public Policy.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Tipping Points: A Survey of the Literature -- Chapter 3. Governance & Resilience: A Stakeholder Agency Perspective -- Chapter 4. Spatial Determinants of Tipping Points Governance: Beyond Stakeholder Agency -- Chapter 5. Governing Social Tipping Points in the EU’s Periphery: A Conceptual Framework & Methodology -- Chapter 6. Resilience in Migration, Climate Change and Geopolitics: A Case of the EU’s Periphery -- Chapter 7. Resilience of the EU’s Periphery vis-à-vis Social Tipping Points: Policy Recommendations -- Chapter 8. Conclusion.
    Abstract: This monograph assesses the intersections between social tipping points (STP), a relatively understudied social-ecological concept, and various public policy concepts, such as governance, state capacity and resilience of the state and non-state actors, all within the context of the EU Eastern and Southern periphery. This unique approach is subsequently embodied in the newly created conceptual framework of how the STPs are governed and analyzed using three case studies. The goal is to examine how various state and non-state actors (transnational, private, and local) have managed to navigate the STPs triggered by migration, climate change, and geopolitics. The multi-level governance of STPs is studied within the context of the EU periphery, thus spatial and geographical determinants of the resilience are analyzed as well.
    Type of Medium: Online Resource
    Pages: XV, 156 p. 28 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031474132
    Series Statement: Key Challenges in Geography, EUROGEO Book Series,
    DDC: 910
    Language: English
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  • 8
    Keywords: Geography. ; Underwater archaeology. ; Geographic information systems. ; Cultural property. ; Archaeology. ; Anthropology. ; Geography. ; Maritime Archaeology. ; Geographical Information System. ; Archaeology and Heritage. ; Cultural Heritage. ; Anthropology.
    Description / Table of Contents: Chapter1. Remains of the shipwreck: an introduction to the Iberian maritime and underwater landscape -- Chapter2. A paradigm of inter and multidisciplinary research: The ForSEAdiscovery project as a case study -- Chapter3. Life and Death in the Spanish Carrera de Indias: ships, merchants, cargoes and routes -- Chapter4. Iberian Ships of the Early Modern Period -- Chapter5. Ship Types in Portugal -- Chapter6. The Iberian Peninsula between two Seas: Shipbuilding Revolution in the Mediterranean and the Atlantic Ocean, 14th–15th centuries -- Chapter7. An insight into Mediterranean naval architecture in the 16th century through the texts of Nicolò Sagri (1538–1571). A comparative perspective with Ibero-Atlantic shipbuilding -- Chapter8. From the Baltic Sea to Andalusia: North European timber (and traders) in 16th-century Seville -- Chapter9. Supplying timber for His Majesty’s fleets: forest resources and maritime struggle in Portugal (1621–1634) -- Chapter10. Historical Documents as sources for the study of shipbuilding in Spain -- Chapter11. Iberian Documents and Treaties on shipbuilding -- Chapter12. Maritime vocabulary in texts: Fray Joseph de Ledesma (1701) -- Chapter13. GIS application on 16th-18th centuries Iberian Shipwrecks.
    Abstract: This two-volume set highlights the importance of Iberian shipbuilding in the centuries of the so-called first globalization (15th to 18th), in confluence with an unprecedented extension of ocean navigation and seafaring and a greater demand for natural resources (especially timber), mostly oak (Quercus spp.) and Pine (Pinus spp.). The chapters are framed in a multidisciplinary and interdisciplinary line of research that integrates history, Geographic Information Sciences, underwater archaeology, dendrochronology and wood provenance techniques. This line of research was developed during the ForSEAdiscovery project, which had a great impact in the academic and scientific world and brought together experts from Europe and America. The volumes deliver a state-of-the-art review of the latest lines of research related to Iberian maritime history and archaeology and their developing interdisciplinary interaction with dendroarchaeology. This synthesis combines an analysis of historical sources, the systematic study of wreck-remains and material culture related to Iberian seafaring from the 15th to the 18th centuries, and the application of earth sciences, including dendrochronology. The set can be used as a manual or work guide for experts and students, and will also be an interesting read for non-experts interested in the subject. Volume 1 focuses on the history and archaeology of seafaring and shipbuilding in the Iberian early modern world, complemented by case studies on timber trade and supply for shipbuilding, analysis of shipbuilding treatises, and the application of Geographic Information Systems and Databases (GIS) to the study of shipwrecks.
    Type of Medium: Online Resource
    Pages: IX, 373 p. 22 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030864606
    DDC: 910
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Environment. ; Environmental policy. ; Sociology. ; Physical geography. ; Environmental management. ; Geography. ; Environmental Sciences. ; Environmental Policy. ; Sociology. ; Physical Geography. ; Environmental Management.
    Description / Table of Contents: Chapter 1: Transformation and the Anthropocene -- Chapter 2: Understanding Change and Governing Transformation -- Chapter 3: Domains of Change in Biodiversity Conservation -- Chapter 4: Novel Decisions and Conservative Frames -- Chapter 5: Cultural Landscapes and Novel Ecosystems -- Chapter 6. Climate Change, Conservation, and Expertise -- Chapter 7. Contested Concepts, Cultures of Knowledge and the Chimera of Change -- Chapter 8. Conclusion: Reform, Reinvention, and Renewal.
    Abstract: This book focuses on the present and future challenges of managing ecosystem transformation on a planet where human impacts are pervasive. In this new epoch, the Anthropocene, the already rapid rate of species loss is amplified by climate change and other stress factors, causing transformation of highly-valued landscapes. Many locations are already transforming into novel ecosystems, where new species, interactions, and ecological functions are creating landscapes unlike anything seen before. This has sparked contentious debate not just about science, but about decision-making, responsibility, fairness, and human capacity to intervene. Clement argues that the social and ecological reality of the Anthropocene requires modernised governance and policy to confront these new challenges and achieve ecological objectives. There is a real opportunity to enable society to cope with transformed ecosystems by changing governance, but this is notoriously difficult. Aimed at anyone involved in these conversations, be those researchers, practitioners, decision makers or students, this book brings together diffuse research exploring how to confront institutional change and ecological transformation in different contexts, and provides insight into how to translate governance concepts into productive pathways forward. Sarah Clement is an environmental governance researcher and lecturer in environmental planning and management in the School of Environmental Sciences, University of Liverpool, UK. She also worked as an environmental consultant, researcher, and environmental policy advisor for 10 years in the USA and Australia.
    Type of Medium: Online Resource
    Pages: XVII, 353 p. 6 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030603502
    Series Statement: Palgrave Studies in Environmental Policy and Regulation,
    DDC: 910
    Language: English
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  • 10
    Keywords: Medicine Research. ; Biology Research. ; Genetics. ; Bioinformatics. ; Biomedical Research. ; Genetics and Genomics. ; Bioinformatics.
    Description / Table of Contents: Chapter 1_Introduction to Pulmonary Diseases and OMICS approaches -- Chapter 2_Obstructive Pulmonary Diseases -- Chapter 3_COPD (Chronic Obstructive Pulmonar Diseases) -- Chapter 4_ Asthma -- Chapter 5_Other obstructive airway diseases like Bronchiectases, Focal airway narrowing -- Chapter 6_Restrictive Pulmonary Diseases (Common qualities and features with examples) -- Chapter 7_Interstitial Pulmonary fibrosis (IPF) -- Chapter 8_Sarcoidosis -- Chapter 9_ Other restrictive airway diseases like pneumonitis, pleural thickening -- Chapter 10_Vascular Diseases -- Chapter 11_Pulmonary hypertension -- Chapter 12_Pulmonary edema -- Chapter 13_ Other vascular diseases like Pulmonary Edema, Cor Pulmonale -- Chapter 14_Infectious Diseases -- Chapter 15_Tuberculosis -- Chapter 16_Cystic fibrosis -- Chapter 17_Pneumonia, COVID-19 and others -- Chapter 18_Neoplastic Diseases/Lung Cancer.
    Abstract: This book comprehensively reviews various omics approaches like genomics, proteomics, transcriptomics, and metabolomics for understanding pulmonary disease at molecular and systems levels. The initial chapters present the pathogenesis of major pulmonary diseases, namely, obstructive diseases, restrictive diseases, vascular diseases, infectious diseases, and neoplastic carcinoma. The book chapters provide current information about the role of the microbiome and applications of medical imaging, bioinformatics tools, and databases for diagnosis and designing treatment strategies against complex lung diseases. Further, the book discusses omics technologies to identify biomarkers for the early diagnosis and prognosis of pulmonary diseases. Finally, the book elucidates the multi-omics approaches and data integration using mathematical modeling for insights into the disease etiology towards improving the prognostics and predictive accuracy of disease phenotypes.
    Type of Medium: Online Resource
    Pages: XIII, 405 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819935055
    DDC: 610.72
    Language: English
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