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  • 1
    Keywords: Medicine Research. ; Biology Research. ; Stem cells. ; Developmental biology. ; Biomedical Research. ; Stem Cell Biology. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Chapter 1. Hematopoietic Stem Cell Development in Mammalian Embryos -- Chapter 2. Hematopoietic Stem Cells and Their Bone Marrow Niches -- Chapter 3. Emerging Roles of Epigenetic Regulators in Maintaining Hematopoietic Stem Cell Homeostasis -- Chapter 4. Metabolism in Hematopoiesis and Its Malignancy -- Chapter 5. The Origin of Clonal Hematopoiesis and Its Implication in Human Diseases -- Chapter 6. Ex vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells -- Chapter 7. N6-methyladenosine RNA Modification in Normal and Malignant Hematopoiesis -- Chapter 8. Immune System Influence on Hematopoietic Stem Cells and Leukemia Development -- Chapter 9. Learning from Zebrafish Hematopoiesis -- Chapter 10. Multi-lineage Differentiation from Hematopoietic Stem Cells -- Chapter 11. Gene Editing in Hematopoietic Stem Cells -- Chapter 12. Aging, Causes and Rejuvenation of Hematopoietic Stem Cells.
    Abstract: This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic.
    Type of Medium: Online Resource
    Pages: XV, 210 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819974719
    Series Statement: Advances in Experimental Medicine and Biology, 1442
    DDC: 610.72
    Language: English
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  • 2
    Keywords: Medicine Research. ; Biology Research. ; Regenerative medicine. ; Biomaterials. ; Biomedical Research. ; Regenerative Medicine and Tissue Engineering. ; Biomaterials.
    Description / Table of Contents: Chapter 1. An Introduction to Scaffolds, Biomaterial Surfaces, and Stem Cells -- Part I. Structural Scaffolds and Bio-activation -- Chapter 2. Polymeric and Biomimetic ECM Scaffolds for Tissue Engineering Applications -- Chapter 3. Versatile Hydrogels in Regenerative Medicine -- Chapter 4. Multilayer Microcapsules with Tailored Structures and Properties as Delivery Carriers for Drugs and Growth Factors -- Part II Biomaterials Surfaces/Interfaces and Bio-interactions. Chapter 5. Interactions of Biomaterial Surfaces with Proteins and Cells -- Chapter 6. Surface Modification of Tissue Engineering Scaffolds -- Chapter 7. Gradient Biomaterials and Their Impact on Cell Migration -- Chapter 8. Stem Cell Differentiation Mediated by Biomaterials/Surfaces -- Part III Regeneration of Some Clinic-Targeted Tissues -- Chapter 9. Cartilage Regeneration -- Chapter 10. Skin Regeneration -- Chapter 11. Regeneration of Blood Vessels -- Chapter 12. Cardiac repair and regeneration -- Chapter 13. Nerve Regeneration.
    Abstract: This book reviews state of the art of polymeric biomaterials for regenerative medicine and highlights advances in both fundamental science and clinical practice. It summarizes the latest techniques in polymeric scaffold fabrication, delivery carriers, physiochemical property modulation, as well as their influence on the adhesion and performance of biomolecules, cells, and tissues. It also describes methods for creating biofunctional surfaces/interfaces and subsequently modulating the host response to implantable materials. Lastly, it discusses the applications of biomaterials and constructs in soft-tissue regenerative medicine. It is a valuable resource for materials scientists and engineers wishing to identify research priorities to fulfill clinical needs and provides physicians with insights into emerging novel biomaterials. This integrated approach also offers engineering students a sense of the relevance of materials science in the development of novel therapeutic strategies. In the second edition, most of the chapters are updated according to the latest progress of this research field. A new chapter on nerve regeneration is also included.
    Type of Medium: Online Resource
    Pages: VIII, 577 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789819969487
    DDC: 610.72
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Genetics. ; Biotechnology. ; Pharmacology. ; Plant Science. ; Genetics and Genomics. ; Biotechnology. ; Pharmacology.
    Description / Table of Contents: Chapter 1. Botanical Features of Periwinkle, Catharanthus roseus -- Chapter 2. Catharanthus roseus: A Source of Anticancer Phytomedicines -- Chapter 3. Classical Breeding and Trait Genetics in Catharanthus -- Chapter 4. Somatic Embryogenesis in Catharanthus roseus: Proteomics of Embryogenic and Nonembryogenic Tissues; and Genome Size Analysis of Regenerated Plant -- Chapter 5. Alkaloid Synthesis in in vitro Cultures of Catharanthus roseus: Capabilities and Limitations -- Chapter 6. Genetic Transformation in Catharanthus roseus -- Chapter 7. Molecular Markers and Descriptor’s Suitable for Quantitative Trait Loci and Genome Mapping in Catharanthus roseus -- Chapter 8. Sequencing the Genome of Catharanthus roseus: Status and Prospects -- Chapter 9. Functional Genomics Approaches for Gene Discovery Related to Terpenoid Indole Alkaloid Biosynthetic Pathway in Catharanthus roseus -- Chapter 10. Future Prospects for Research on Catharanthus roseus.
    Abstract: This book is the first comprehensive compilation of deliberations on botany, medicinal importance, genetic diversity, classical genetics and breeding, in vitro biosynthesis, somatic embryogenesis, genetic transformation, molecular mapping, genome sequence, and functional genomics of Catharanthus roseus. Catharanthus is the most important medicinal plant in the world that contains about 130 therapeutic alkaloids out of which vinblastine and vincristine are the two highly used anticancer drugs sold by the pharmaceutically industries. Altogether, the book contains about 10 chapters authored by globally reputed experts on the relevant field of this plant. This book is useful to the students, teachers and scientists in the academia and relevant private companies interested in horticulture, genetics, breeding, pathology, entomology, physiology, molecular genetics and breeding, in vitro culture and genetic engineering, and structural and functional genomics. This book is also useful to pharmaceutical industries.
    Type of Medium: Online Resource
    Pages: XXV, 183 p. 86 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030892692
    Series Statement: Compendium of Plant Genomes,
    DDC: 580
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Genetics. ; Biotechnology. ; Agriculture. ; Plant Science. ; Genetics and Genomics. ; Biotechnology. ; Agriculture.
    Description / Table of Contents: Chapter 1. Economic Importance, Practical Limitations to Production, Management and Breeding Targets of Alfalfa -- Chapter 2. Factors Influencing Yield and Quality -- Chapter 3. The Origin, Evolution and Genetic Diversity of Alfalfa -- Chapter 4. Germplasm Collection, Genetic Resources and Gene Pools in Alfalfa -- Chapter 5. Biotechnology Advances in Alfalfa -- Chapter 6. Sequencing, Assembly and Annotation of the Alfalfa Genome -- Chapter 7. Transcription Factors in Alfalfa (Medicago sativa L.): Genome-Wide Identification and a Web Resource Center AlfalfaTFDB -- Chapter 8. Genomics of Forage Quality in Alfalfa -- Chapter 9. Physiological, Morphological, Biochemical, and Genetic Responses of Alfalfa to Salinity -- Chapter 10. Developing SNPs and Strategies for Genomic Analysis in Alfalfa -- Chapter 11. Genomics Resources for Breeding in Alfalfa: Availability, Utility, and Adoption -- Chapter 12. Genomic Selection for Higher Yield and Quality in Alfalfa -- Chapter 13. Identification and Characterization of Disease Resistance Genes in Alfalfa and Medicago truncatula for Breeding Improved Cultivars -- Chapter 14. Genetic and Genomic Assessments for Improving Drought Resilience in Alfalfa -- Chapter 15. Self-Incompatibility, Inbreeding Depression, and Potential to Develop Inbred Lines in Alfalfa -- Chapter 16. Targeted Mutagenesis of Alfalfa.
    Abstract: This book is the first comprehensive compilation of deliberations on whole genome sequencing of the diploid and tetraploid alfalfa genomes including sequence assembly, gene annotation, and comparative genomics with the model legume genome, functional genomics, and genomics of important agronomic characters. Other chapters describe the genetic diversity and germplasm collections of alfalfa, as well as development of genetic markers and genome-wide association and genomic selection for economical important traits, genome editing, genomics, and breeding targets to address current and future needs. Altogether, the book contains about 300 pages over 16 chapters authored by globally reputed experts on the relevant field in this crop. This book is useful to the students, teachers, and scientists in the academia and relevant private companies interested in genetics, breeding, pathology, physiology, molecular genetics and breeding, biotechnology, and structural and functional genomics. The work is also useful to seed and forage industries.
    Type of Medium: Online Resource
    Pages: XXV, 283 p. 64 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030744663
    Series Statement: Compendium of Plant Genomes,
    DDC: 580
    Language: English
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  • 5
    Keywords: Botany. ; Environment. ; Biotechnology. ; Renewable energy sources. ; Cogeneration of electric power and heat. ; Fossil fuels. ; Plant Science. ; Environmental Sciences. ; Biotechnology. ; Renewable Energy. ; Fossil Fuel.
    Description / Table of Contents: Introduction: values of pollution free atmosphere -- Plant and Algae Classes Recognition, Biomass Production and Potential Source of Biofuel -- Plant and Algae Metabolites Alternative and Clean Source of Energy -- Mechanism and methods of extraction of biofuels -- Metabolic routes to biofuels extraction -- Optimizations on steps involved on biofuel obtainment and their validation -- Economic consideration on biofuel and energy security -- Technical challenges of biofuel obtainment -- Conclusion and Future Perspectives.
    Abstract: This volume discusses how plant and algae organisms play a pivotal role in the transformation of solar energy to essential metabolites, and explores the numerous beneficial roles these metabolites have at an industrial level. It presents information on the utilization of plant and algae for biomass production, and shows how this is a practical option for large scale biofuel production. The book examines how these bio-metabolites can then be used to extract biofuel. Biomass produced from plants and algae can act as the source of feedstock for biofuel production and industrially important compounds. This book also explores that by curtailing culturing cost using wastewater, seawater, and industrial water as a nutrient and water source, biomass becomes an economical energy source. The introductory chapters of the book focus on the appreciative values of a pollution-free atmosphere, with special reference to enhanced greenhouse effect, and then are followed by chapters on the potential of plant and algae as a liquid energy resource. This book targets researchers, graduate students, and energy and fuel industry professionals interested in the plant sciences, biotechnology and renewable energy. .
    Type of Medium: Online Resource
    Pages: XV, 164 p. 21 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030940744
    DDC: 580
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Environmental economics. ; Plant ecology. ; Economic geography. ; Environmental management. ; Plant Science. ; Environmental Economics. ; Plant Ecology. ; Economic Geography. ; Environmental Management.
    Description / Table of Contents: Chapter 1. Introduction -- Chp 2: Amchur -- Chp.3:Anardana -- Chp 4:Balm or Lemon Balm -- Chp.5:Basil or Sweet Basil (Tulsi) -- Chp.6:Bay or Laurel Leaves -- Chp 7: Kokam or Kokum -- Chp 8:Juniper -- Chp.9: Hyssop -- Chp 10: Marjoram -- Chp 11: Japanese Mint -- Chp: 12: Peppermint -- Chp 13: Spearmint -- Chp 14. Origanum -- Chp 15: Parsley -- Chp 16: Rosemary -- Chp 17: Ashwagndha -- Chp 18.:Manathakkali.
    Abstract: This book discusses leafy spices or herbs known as “aromatic herbs”, which, apart from being used in culinary art for flavoring of foods and beverages, are also known to possess antiseptic, anti-oxidant and other medicinal properties, in addition to many nutraceutical and cosmetic properties. Of the numerous herbs twelve of the commercially important herbs are imported into 4 major European markets, namely, France, Germany, United Kingdom and The Netherlands to the tune of 12000 to 13000 tonnes per annum. This book discusses these leafy herbs and their tremendous commercial potential in international trade. The book offers a comprehensive insight into commercial herbs, with an objective of enhancing their yield, and provides a platform for further research into the global trade potential.
    Type of Medium: Online Resource
    Pages: XIV, 141 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031043604
    DDC: 580
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Food science. ; Plant ecology. ; Economic geography. ; Agriculture. ; Plant Science. ; Food Science. ; Plant Ecology. ; Economic Geography. ; Agriculture.
    Description / Table of Contents: Preface -- Chapter 1 Introduction -- Chapter 2 The Pepper Plant—Its Botany and Chemistry -- Chapter 3 Pepper Agronomy -- Chapter 4 The Role of the Nutrient Buffer Power Concept in Pepper Nutrition -- Chapter 5 Establishing a Pepper Plantation -- Chapter 6 Pepper Pests and Their Control -- Chapter 7 The Processing of Black Pepper on Farm -- Chapter 8 An Account of Indonesian Pepper Processing -- Chapter 9 Industrial Processing of Black Pepper -- Chapter 10 The Future of the Global Pepper Economy -- Chapter 11 Pepper Economy in India -- Chapter 12 Pepper Pharmacopoeia -- Chapter 13 Consumer Products Out of Black Pepper -- Chapter 14 Value Addition in Pepper -- Chapter 15 Conclusions and a Peep Into Pepper’s Future -- PRECISE QUANTIFICATION OF PLANT NUTRIENT BIO AVAILABILITY FOR BLACK PEPPER AND CARDAMOM -- TECHNOLOGICAL INNOVATIONS IN SPICES RESEARCH AND DEVELOPMENT!!!.
    Abstract: This book considers all aspects of black pepper from its growth, as a flowering vine, to how the dried fruit (peppercorn) is used as a spice and traded as a commodity. It is the economic mainstay of several India states and, principally, in Kerala State, with the Indian subcontinent being the largest black pepper producer. Indonesia has also emerged as a large producer of black pepper. Black pepper commands a leading position among the spices and has an immense commercial importance to world trade, finding its way onto the dining table of millions around the world, on the European and North American continents, and Japan. The use of black pepper ranges from a simple dietary component and flavour enhancer, to that of a spice with huge pharmacological benefits. .
    Type of Medium: Online Resource
    Pages: XIV, 162 p. 24 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030528652
    DDC: 580
    Language: English
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  • 8
    Keywords: Botany. ; Microbiology. ; Agriculture. ; Bioinformatics. ; Microbial ecology. ; Physical geography. ; Plant Science. ; Microbiology. ; Agriculture. ; Bioinformatics. ; Microbial Ecology. ; Earth System Sciences.
    Abstract: The third volume of the series ‘Bacilli and Agrobiotechnology’ is comprised of 25 chapters that bring a unique perspective to the readers about Bacillus-mediated biotic and abiotic plant stress tolerance, bioremediation and bioprospecting. These chapters are prepared by the leading scientists of global repute. The negative impacts of agrochemicals such as chemical fertilizers and pesticides on human health and environment are paramount. Bacillus and allied genera of beneficial plant-associated microbes are presenting beacon of hope to the farmers, plant scientists and stewards of environment. Several chapters of this volume focus on the induction of various signaling pathways in plants by Bacillus spp. to alleviate biotic and abiotic stresses impacted by global climate change Agricultural lands contaminated with heavy metals affect the ecological food chain starting from crop cultivation. How the toxic effects of trace metals originating from industrial effluents and agrochemicals can be remediated? This book addresses how to overcome these issues by applying elite strains of Bacillus. Bioprospecting is a systematic and organized search for conversion of bioresources to industrially important products by utilizing microbe-derived metabolites. This volume is enriched by including the bioprospecting aspects mediated by Bacillus spp. with novel insights.
    Type of Medium: Online Resource
    Pages: VII, 612 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030854652
    Series Statement: Bacilli in Climate Resilient Agriculture and Bioprospecting,
    DDC: 580
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Medicine Research. ; Biology Research. ; Anatomy. ; Information visualization. ; Biophysics. ; Biomedical Research. ; Anatomy. ; Data and Information Visualization. ; Bioanalysis and Bioimaging.
    Description / Table of Contents: Chapter 1. The Importance of Integrating the Visual Arts into the Medical Curriculum -- Chapter 2. Using Medical Illustration to Improve Understanding of Endometriosis -- Chapter 3. Editorial Medical and Scientific Illustration -- Chapter 4. Current Approaches in Narrative Medical Visualization -- Chapter 5. Animation for Science Communication: A Description of the Production Process and Contexts for Using Science Animation -- Chapter 6. Effect of the Rings: A Visual Story Design Comparing Three Chemical Characters -- Chapter 7. Diabetes Year One, Random Fluctuations and Mental Goblins: Auto-Ethnographic Pathographies and Medical Comics -- Chapter 8. Playing with Science: Games as a Medium of Science Communication -- Chapter 9. Increasing Microbiology Literacy about the Public Health Threat of Antimicrobial Resistance Through Art-Science Interactions -- Chapter 10. Collaged Creatures: Using Collage Art Practice and Posthuman Ethics to Discuss Bioengineering Hybrids.
    Abstract: This edited book explores the breadth of approaches undertaken by scientists, artists and communicators in their crucial role making science accessible, engaging and impactful. Contemporary approaches in science illustration and visualization include a variety of creative methodologies that are valuable for effective communication, teaching, learning and professional practice. These range in method from anatomical drawings used in medical curricula, to 2D animations and editorial illustrations available in the public realm. They also include unexpected approaches such as the use of tabletop board games, comics and collage in understanding our bodies, emergent health threats and cutting-edge science developments. If you are a scientist seeking to enhance your ability to communicate your research or an artist interested in biomedical visualization, this volume serves as an introduction to contemporary approaches in science illustration and communication. By understanding the creative methods and techniques employed in this field, we can collectively work towards fostering a deeper appreciation of art in science, and continue to captivate and inspire audiences worldwide. .
    Type of Medium: Online Resource
    Pages: XVI, 252 p. 158 illus., 140 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031416521
    Series Statement: Biomedical Visualization, 4
    DDC: 610.72
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Botany. ; Agriculture. ; Biomolecules. ; Physical biochemistry. ; Macromolecules. ; Plant Science. ; Agriculture. ; Structural Biology.
    Description / Table of Contents: 1. Introduction -- 2. Floral morphology and phenology -- 3. Pollen grain morphology, viability, and insect visitation -- 4. The phenology of Rubus glaucus Benth. characterized by the BBCH scale -- 5.Propagation and cultivation -- 6.Fruit and chromosome number -- 7.Post-harvest physiology and nutritional facts -- 8.Genetic diversity -- 9.Breeding programs -- 10.Morphological diversity -- 11.Rubus glaucus and climate change.
    Abstract: The current book focuses on Mora de Castilla (Rubus glaucus Benth.). It explores aspects, such as origin, phenology, propagation, floral and fruit morphology, arthropod visitors, pollination mechanisms, propagation methods, chromosome number, fruit development, breeding, morphological diversity, and the impact of climate change. It includes novel data about plant phenology, flowering, insect visitors, seed germination, fruit morphology, and allometric relationships. This work includes an in-depth review of the most recently published information on the topic. Mora de Castilla is an economically important fruit crop from the Andes. It has been crossed with other Rubus species due to its high yield and everbearing habit. Currently, it is an economically important plant. It has been hybridized with other Rubus species producing new and better-quality hybrids This book contains numerous photographs selected by the author to provide the reader with detailed information about the plant´s morphological features and arthropod visitors. .
    Type of Medium: Online Resource
    Pages: XVIII, 178 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031317507
    DDC: 580
    Language: English
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  • 11
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Plant physiology. ; Botanical chemistry. ; Agriculture. ; Plant Science. ; Plant Physiology. ; Plant Biochemistry. ; Agriculture.
    Description / Table of Contents: Chapter 01: The Role of Gas Transmitters in Plant Hormonal Responses to Abiotic Stress -- Chapter 02: Understanding the involvement of gasotransmitters in the regulation of cellular signalling and adaptive responses against UV-B mediated oxidative stress in plants -- Chapter 03 Signaling Pathways of Gasotransmitters in Heavy Metal Stress Mitigation -- Chapter 04: Volatile signaling molecules in plants and their interplay with the redox balance under challenging environments: new insights -- Chapter 05: Alleviation of Plant Stress by Molecular Hydrogen -- Chapter 06: Understanding the role of nitric oxide and its interactive effects with phytohormones in mitigation of salinity stress -- Chapter 07 Nitric oxide – a small molecule with big impacts on plants under heavy metal stress -- Chapter 08: Nitric oxide: a key modulator of postharvest fruit and egetable physiology -- Chapter 09: Interaction of hydrogen sulfide with other phytohormones during physiological and stress conditions -- Chapter 10: Gasotransmitter hydrogen sulfide (H2S) and its role in plant development and defense responses -- Chapter 11 Hydrogen Sulfide (H2S) signaling in plants responding to abiotic stresses -- Chapter 12 Hydrogen sulfide metabolism and its role in regulating salt and drought stress in plants -- Chapter 13 Functional Roles of Hydrogen Sulphide in Postharvest Physiology of Fruit and Vegetables -- Chapter 14: Carbon compounds as gasotransmitters in plants under challenging environment -- Chapter 15: Carbon monoxide (CO) and its association with other gasotransmitters in root development, growth and signaling.
    Abstract: The book "Gasotransmitters Signaling in Plants under Challenging Environment" provides a comprehensive overview of the current state of knowledge on the role of gasotransmitters in plant stress responses. This edited volume delves deep into the captivating realm of gasotransmitters and their pivotal role in plant response to challenging environmental conditions. It brings together a wealth of cutting-edge research from around the world by leading experts in the field of gasotransmitter signaling in plants. Gasotransmitters, including nitric oxide, hydrogen sulfide, and carbon monoxide, have long been recognized as essential mediators of cellular signaling in animals. However, recent research has unveiled their incredible importance in orchestrating plant responses to environmental stresses. From drought and heat to pollution and pathogens, these tiny molecules serve as potent messengers, navigating plants through adversity and fostering their resilience in the face of an ever-changing world. As the world faces unprecedented environmental challenges, the knowledge presented in this book opens new avenues for sustainable agriculture and biotechnological interventions. The book provides an overview of the basic biology of gasotransmitters, including their production, metabolism, and signaling mechanisms. Further, it discusses the role of gasotransmitters in plant responses to specific abiotic stresses, such as drought, salinity, heavy metal toxicity, and high temperatures. The book also focuses on the potential applications of gasotransmitters in plant biotechnology. "Gasotransmitters Signaling in Plants under Challenging Environment" is an essential resource for researchers, students, and anyone interested in understanding the role of gasotransmitters in plant stress responses.
    Type of Medium: Online Resource
    Pages: VIII, 328 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031430299
    Series Statement: Plant in Challenging Environments, 5
    DDC: 580
    Language: English
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  • 12
    Keywords: Botany. ; Plant ecology. ; Plant diseases. ; Plant Science. ; Plant Ecology. ; Plant Pathology.
    Description / Table of Contents: Ch 1. Plant invasion and climate change: a global overview -- Ch 2. Impacts of plant invasions on ecosystem functionality: a perspective for ecosystem health and ecosystem services -- Ch 3. Menace of Plant Invasion: A View from Ecological Lens -- Ch 4. Role of extreme climate events in amplification of plant invasion -- Ch 5. Plant Invasion as Gleaned from Parasara's Vrkshayurveda -- Ch 6. Water, wind, and fire: extreme climate events enhance the spread of invasive plants in sensitive North American ecosystems -- Ch 7. Understanding eco-geographical relationship in invaded ranges by Acacia longifolia (Andrews) Willd. – An intercontinental case study on Acacia invasions -- Ch 8. Invasive plants in India: their adaptability, socio-ecological impacts, and response to changing climate -- Ch 9. Plant invasion in an aquatic ecosystem: A new frontier under climate change -- Ch 10. Plant invasion and soil processes: A mechanistic understanding -- Ch 11. Plant invasion dynamics in mountain ecosystems under changing climate scenario -- Ch 12. The role of epigenetics on plant invasions under climate change scenario -- Ch 13. Comparative assessment of Machine Learning Algorithms for habitat suitability of Tribulus terrestris (Linn): An economically important weed -- Ch 14. Strategies of plant invasion and management for the conservation and restoration of degraded poor agricultural lands -- Ch 15. Plant Invasion and Climate Change: An Overview on History, Impacts and Management Practices -- Ch 16. Biochar: a tool for combatting both invasive species and climate change -- Ch 17. An action plan to prevent and manage alien plant invasions in India.
    Abstract: This edited book provides an ensemble of contemporary research related to the challenges, impacts and precautionary measures for tackling plant invasions in the context of changing climate in different regions of the world. In current scenario, plant invasions are expansive and significant component of anthropogenic global climate change. Temperature variations may compromise the adaptability of native species, thereby stressing them and decreasing the resistance potential of natural communities to invasion. Invasive alien species under the current scenario have been suggested as a major threat to biodiversity. It is also predicted that increasing disturbances or extreme events such as fires, floods, cyclones, storms, heat-waves, droughts, etc. will be direct consequences of changing climate supporting the invasive alien species. A comprehensive understanding of the interaction between species invasion and climate change will be supplemental in forecasting future shifts in biodiversity. Further, different predictive models indicate a plausible increase in the abundance and impact of invasive alien species which may have direct implications for future research and target-oriented policy and decision making. However, these predictions become more complicated considering the complexity of interactions between the impacts of changing climate with other components of global change (changes in land use, nitrogen deposition, etc.) which are affecting the distribution of native plant species, ecosystem dynamics as well as non-native/invasive species. This book will be suitable for students (undergraduate and postgraduates) of agriculture, forestry, ecology, soil science, and environmental sciences; teachers, researchers, and climate change scientists in academic and research institutions. It will also be applicable to environmental management agencies, government agencies and policy makers. .
    Type of Medium: Online Resource
    Pages: XVII, 418 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819959105
    DDC: 580
    Language: English
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  • 13
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Botany. ; Plant physiology. ; Plant diseases. ; Plant Science. ; Plant Physiology. ; Plant Pathology.
    Description / Table of Contents: Chapter 1 -- Root-knot Nematodes (Meloidogyne spp.), Chapter 2 -- Meloidogyne species: Threat to Vegetable Produce, Chapter 3 -- hemotaxis in Root-Knot Nematodes, Chapter 4 -- Phytohormone-Mediated Feeding Site Development, Chapter 5 -- 5. Current and Future Studies on the Genes for Parasitism in Meloidogyne, Chapter 6 -- Natural Product Repertoire for Suppressing the Immune Response of Meloidogyne species, Chapter 7 -- Epigenetic Mechanisms and their Role in Root Gall Formation,Chapter 8 -- Mass Spectrometry Imaging (MSI) and Root Gall Elucidation, Chapter 9 -- 9. Root-Knot Disease Complex: An Interactive Perspective with Microorganisms, Chapter 10 -- Breeding for Resistance in Vegetables against Meloidogyne species causing Root Gall Disease, Chapter 11 -- An Overview of Predacious Fungi for the Management of Root-knot Disease in Vegetables, Chapter 12 -- Biofertilizer of Organic Origin for Management of Root Galling Disease of Vegetables, Chapter 13 -- Prospects for the Use of Metabolomics Engineering in Exploring and Harnessing Chemical Signalling in Root Galls.
    Abstract: This book provides the most comprehensive and up-to-date review of research on vegetable plants associated with root-galls disease caused by root-knot nematodes (RKNs), Meloidogyne spp. Vegetables retain a key position in cultural cuisines and their consumption worldwide due to rich sources of micronutrients, including vitamins, minerals and antioxidants, but root galls disease of these crops caused by RKNs steals both quantity and quality from production. The field of plant nematology has experienced exponential growth over the past decade, and these RKNs are now known as widely damaging obligate plant parasites of vegetable plants. Advances are being made in understanding their biology, parasitism in the root system, giant cell development, root gall formation, chemical signalling, root-knot disease complexes, and management systems. This compilation provides an invaluable resource for studying root-galls disease of vegetable plants to those readers associated with plant nematology, plant pathology, plant protection, and agricultural science, including researchers, teachers, advanced undergraduates and graduate students, and even agricultural extension agents and farmers.
    Type of Medium: Online Resource
    Pages: XIX, 338 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819938926
    DDC: 580
    Language: English
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  • 14
    Keywords: Botany. ; Human ecology Study and teaching. ; Plant Science. ; Environmental Studies.
    Description / Table of Contents: 1. Agronomic Biofortification- An Effective Tool for Alleviating Nutrient Deficiency in Plants and Human Diet -- 2. The Role of Biofortification in Enhancing Plant Growth, Development, Yield, and Quality -- 3. Improving Zinc Biofortification in Plants 4. Biofortification of Zinc: Uptake from the Soil and Transportation up to the Grains through ZIP Family Transporters -- 5. Mechanisms of Iron Uptake and Homeostasis in Plants: Implications for Biofortification in Cereal Grains -- 6. Selenium Biofortification in Agronomic Crops -- 7. Selenium Bio-fortification in Cereal Crops: An Overview -- 8. Nanoparticles Based Biofortification in Food Crops: Overview, Implications, and Prospects -- 9. Role of Nanoparticles in Improving Biofortification -- 10. Role of Nanoparticles in Improving Biofortification of Zinc and Iron in Vegetables -- 11. Scope of Seed Priming in Inducing Biofortification in Plants -- 12. Biofortification Through Seed Priming in Food Crops; Potential Benefits and Future Scope -- 13. Biochar for the Improvement of Crop Production -- 14. Phytohormones as Stress Mitigators in Plants.
    Abstract: This book provides a comprehensive summary of the recent advances in the biofortification of plants under climate change and how it affects food security globally. The need for mineral biofortification to eradicate or alleviate malnutrition through sustainable agriculture is also discussed. Biofortification of edible plants is considered the most appropriate approach to alleviate nutritional problems and nutrient deficiencies. In contrast, biofortification focuses on improving the nutritional content of the region's current agricultural biodiversity while preserving its habits and customs. Emphasis is also placed on recent advances and developments in omics, particularly metabolomics and related techniques, to unravel the potential alterations in plants caused by biofortification. The book brings together eminent scientists to present the latest developments in the field. This timely publication addresses practical scenarios of bio-fortified food production and climate change. The book focuses on the methods, techniques, and environmental changes used to enhance and improve agricultural products. This book is one of the first to provide information on the use of modern biotechnologies to modify crops for health benefits. It also examines the mechanisms of the plant responses to genetically induced biofortification, the production and responses of fortified plants under climate change, and their effects on food security. The book will be useful for students and researchers, especially crop scientists, environmental scientists, biotechnologists, botanists, and agronomists, to understand the techniques and mechanisms of biofortification, and responses of biofortified plants under climate change.
    Type of Medium: Online Resource
    Pages: XI, 338 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819940905
    DDC: 580
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Agriculture. ; Plant physiology. ; Plant Science. ; Agriculture. ; Plant Physiology.
    Description / Table of Contents: Introduction to MAPs in Turkey -- Ethnobotany in Turkey: Retrospect and Prospect -- Natural Dye Plants in Turkey -- Phytochemical and Biological Characteristics of Apiaceae (Umbelliferae) Species from Turkey.-The genus Salvia in Turkey: Morphology, Ecology, Phytogeograpy, Endemism and Threat Categories -- Threatened Medicinal and Aromatic Plants and Conservation Studies in Turkey -- Cultivation and Breeding of MAPs in Turkey -- Traditional Uses and Cultivation of St. John’s Wort (Hypericum perforatum L.) in Türkiye -- Turkish Oregano (Origanum spp.) – Biodiversity, Cultivation, Traditional & Commercial Uses -- Traditional Medicinal and Aromatic Trees in Turkiye: Laurel (Laurus nobilis), Sumac (Rhuscoriaria), Hawthorn (Crataegus spp.) and Carob (Ceratonia siliqua) -- Turkish Soaproot (Radix gypsophylae) -- Traditional Farming of Apiaceae Species in Turkiye: Pimpinella anisum L., Foeniculum vulgare Mill., Cuminum cyminum L.) -- Traditional Uses of Turkish Asteraceae Species -- Anti-aging effect of Turkish medicinal plants on skin: Focus on recent studies.
    Abstract: This is meant to be the 10th volume of the series Medicinal and Aromatic Plants of the World. Similarly, to the previous volumes, the work will deal -in a monographic form- with MAPs characteristic/famous or simply known of Turkey, a large country that is connecting Europe with Asia. Turkey has extremely rich and varied topographic/ecologic conditions. As a result, the flora of Turkey abounds in an astonishingly great number of endemic MAP species. Traditional, present and possible prospective uses will be discussed. Scientific and technological achievements will be equally presented. Briefly, the volume is aimed to look carefully at our present knowledge of this vast interdisciplinary domain of medicinal and aromatic plants with a focus on Turkey. In the era of global climate change and Covid-pandemics, building on the huge Turkish traditions, the proposed volume of the series is expected to make an important contribution to the better knowledge and understanding of the MAP wealth of the World.
    Type of Medium: Online Resource
    Pages: X, 327 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031433122
    Series Statement: Medicinal and Aromatic Plants of the World, 10
    DDC: 580
    Language: English
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  • 16
    Keywords: Medicine Research. ; Biology Research. ; Genetics. ; Bioinformatics. ; Biomedical Research. ; Genetics and Genomics. ; Bioinformatics.
    Description / Table of Contents: Chapter 1_Introduction to Pulmonary Diseases and OMICS approaches -- Chapter 2_Obstructive Pulmonary Diseases -- Chapter 3_COPD (Chronic Obstructive Pulmonar Diseases) -- Chapter 4_ Asthma -- Chapter 5_Other obstructive airway diseases like Bronchiectases, Focal airway narrowing -- Chapter 6_Restrictive Pulmonary Diseases (Common qualities and features with examples) -- Chapter 7_Interstitial Pulmonary fibrosis (IPF) -- Chapter 8_Sarcoidosis -- Chapter 9_ Other restrictive airway diseases like pneumonitis, pleural thickening -- Chapter 10_Vascular Diseases -- Chapter 11_Pulmonary hypertension -- Chapter 12_Pulmonary edema -- Chapter 13_ Other vascular diseases like Pulmonary Edema, Cor Pulmonale -- Chapter 14_Infectious Diseases -- Chapter 15_Tuberculosis -- Chapter 16_Cystic fibrosis -- Chapter 17_Pneumonia, COVID-19 and others -- Chapter 18_Neoplastic Diseases/Lung Cancer.
    Abstract: This book comprehensively reviews various omics approaches like genomics, proteomics, transcriptomics, and metabolomics for understanding pulmonary disease at molecular and systems levels. The initial chapters present the pathogenesis of major pulmonary diseases, namely, obstructive diseases, restrictive diseases, vascular diseases, infectious diseases, and neoplastic carcinoma. The book chapters provide current information about the role of the microbiome and applications of medical imaging, bioinformatics tools, and databases for diagnosis and designing treatment strategies against complex lung diseases. Further, the book discusses omics technologies to identify biomarkers for the early diagnosis and prognosis of pulmonary diseases. Finally, the book elucidates the multi-omics approaches and data integration using mathematical modeling for insights into the disease etiology towards improving the prognostics and predictive accuracy of disease phenotypes.
    Type of Medium: Online Resource
    Pages: XIII, 405 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819935055
    DDC: 610.72
    Language: English
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  • 17
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Agriculture. ; Plant diseases. ; Plant Science. ; Agriculture. ; Plant Pathology.
    Description / Table of Contents: 1. Medicinal and Aromatic Plants in India: A bridge from Traditions to modern wellbeing -- 2. Holy basil (Ocimum sanctum L.) - an important indian medicinal and aromatic plant: its properties, utilization and genetic improvement -- 3. Ethnomedicinal Importance of Common Weeds of the Family Asteraceae in the Tribal Belt of Rajasthan, India -- 4. Cydonia oblonga Mill. - Wound healing properties -- 5. Artemisia annua L. - A comprehensive review on pharmacological properties -- 6. Mesua ferrea L - Ethnobotany, Phytochemistry and Pharmacology -- 7. Linum usitatissimum L. - Rich store house of pharmacologically active metabolites -- 8. Gymnema sylvestre R.Br.: - Phytochemicals and Medicinal Properties -- 9. Medicinal and Aromatic plants of India used in the treatment of skin disorders -- 10. Traditional uses and properties of Indian medicinal plants in the treatment of Vitiligo -- 11. Indian MAPs with hepato-protectant potentials -- 12. Selected Medicinal Plants for Treatment of Mucormycosis, in India -- 13. Selected Indian Medicinal And Aromatic Plants For Prophylactic Therapy -- 14. Conservation Strategies Of Indian Medicinal Plants.
    Abstract: This book is the 9th volume in the series Medicinal and Aromatic Plants of the World. India being one of the countries with the longest and richest past/present/future of Medicinal and Aromatic Plant (MAP) production and utilization has accumulated more than sufficient knowledge to fill two volumes. This is shown by the vivid interest of Indian colleagues to contribute. Similar to the previous volumes, this one deals with the various important aspects (from botanical through phytochemical to pharmacological) of MAPs', famous or simply known of India. Scientific and technological achievements will be equally presented. In addition to the first volume, India V1, this volume is aimed to look carefully at our present knowledge of this vas interdisciplinary domain with an Indian focus. In the era of global climate change and pandemics, building on the huge Indian traditions, this book is expected to make an important contribution to the better knowledge and understanding of MAPs.
    Type of Medium: Online Resource
    Pages: X, 302 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031449147
    Series Statement: Medicinal and Aromatic Plants of the World, 9
    DDC: 580
    Language: English
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  • 18
    Keywords: Medicine Research. ; Biology Research. ; Forensic sciences. ; Medical jurisprudence. ; Biomedical Research. ; Forensic Science. ; Forensic Medicine.
    Description / Table of Contents: Module 1_Introduction to Forensic Science & Crime -- Module 2_Criminalistics -- Module 3_ Forensic Biological Sciences -- Module 4_Forensic Physical Sciences -- Module 5_Forensic Chemical Sciences -- Module 6_Emerging fields in Trends in Forensics.
    Abstract: This textbook provides essential and fundamental information to modern forensics investigations. It discusses criminalistics and crime scene aspects, including investigation, management, collecting and packaging various types of physical evidence, forwarding, and chain of custody. It presents fundamental principles, ethics, challenges and criticism of forensic sciences and reviews the crime typologies, the correlates of crime, criminology, penology, and victimology. It provides a viewpoint on legal aspects, including types of evidence, the procedure in the court and scrutiny of the evidence and experts. The book summarizes forensic serological evidences such as blood, semen, saliva, milk-tears, sweat, vaginal fluids, urine, and sweat. It also provides an overview of forensic examination of different types of evidence and also includes comprehensive detailing of forensic ballistics including firearm classification, bullet comparison and matching. Further, it explores the examinations of drugs, chemicals, explosives, and petroleum products. It focuses on the various aspects of forensic toxicology, including the study of various poisons/toxins, associated signs and symptoms, a fatal dose /fatal period of poisons. The book also emphasizes digital and cyber forensics, including classification, data recovery tools, encryption and decryption methods, image, and video forensics. It is a useful resource for graduate and post-graduate students in the field of Forensic Science.
    Type of Medium: Online Resource
    Pages: XV, 839 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819913770
    DDC: 610.72
    Language: English
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  • 19
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Neurology . ; Neurosciences. ; Nervous system Diseases. ; Biomedical Research. ; Neurology. ; Neuroscience. ; Neurological Disorders.
    Description / Table of Contents: PART I: Fundamental Aspects -- Chapter 1. Definition of Tremor -- Chapter 2. Membrane Mechanisms of Tremor -- Chapter 3 Advances in the Genetics of Human Tremor -- Chapter 4. Two origins of tremors related to the Guillain-Mollaret triangle: the forward model-related tremor and the inferior olive oscillation-related tremor -- PART II:Tremor in Clinical Practice -- Chapter 5. Physiologic Tremor -- Chapter 6. Rest Tremor -- Chapter 7. Postural Tremors -- Chapter 8. Isometric Tremor -- Chapter 9. Essential Tremor and Other Forms of Kinetic Tremor -- Chapter 10. Cerebellar lesions and tremor -- Chapter 11. Orthostatic Tremor -- Chapter 12. Posttraumatic Tremor and Other Posttraumatic Movement Disorders -- Chapter 13 Tremor in Childhood -- Chapter 14. Metabolic Causes of Tremor -- Chapter 15. Drug-Induced Tremor -- Chapter 16. Tremor: The Clinical Approach to Reach the Diagnosis -- PART III: Assessment of tremor -- Chapter 17. Signal Processing -- Chapter 18. Diffusion imaging in Tremor -- Chapter 19. The role of the noradrenergic system in tremor pathogenesis -- Chapter 20. Metabolic Networks in Parkinson’s Disease -- PART IV: Therapies -- Chapter 21. Deep brain stimulation for tremor -- Chapter 22 Mechatronic Devices for Upper Limb Tremor.
    Abstract: Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.
    Type of Medium: Online Resource
    Pages: X, 558 p. 86 illus., 59 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031261282
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 610.72
    Language: English
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  • 20
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Genetics. ; Biotechnology. ; Agriculture. ; Plant Science. ; Genetics and Genomics. ; Biotechnology. ; Agriculture.
    Description / Table of Contents: Chapter 1. The Broomcorn Millet Genome -- Chapter 2. Buckwheat Genome and Genomics -- Chapter 3. Tef [Eragrostistis tef (Zucc.) Trotter] -- Chapter 4. The Apricot Genome -- Chapter 5. Chinese Jujube: Crop Background and Genome Sequencing -- Chapter 6. The Longan (Dimocarpus longan) Genome -- Chapter 7. The Mangosteen Genome -- Chapter 8. The Passion Fruit Genome -- Chapter 9. The Soursop Genome (Annona muricata L., Annonaceae) -- Chapter 10. Underutilised Fruit Tree Genomes from Indonesia -- Chapter 11. The Bambara Groundnut Genome: From the Crop to the Genome -- Chapter 12. Grasspea -- Chapter 13. The Lablab Genome -- Chapter 14. The Perennial Horse Gram (Macrotyloma axillare) Genome, Phylogeny, and Selection Across the Fabaceae -- Chapter 15. Breeding and Genomics of Pigeonpea in the Post-NGS Era -- Chapter 16. Rice Bean -- Chapter 17. The Winged Bean Genome: One Species Supermarket -- Chapter 18. Castor Bean: Recent Progress in Understanding the Genome of this Underutilized Crop -- Chapter 19. Genome Resources for Ensete Ventricosum (enset) and Related Species -- Chapter 20. Yam Genomics -- Chapter 21. The African Eggplant -- Chapter 22. Sequencing of the Bottle Gourd Genomes Enhances Understanding of the Ancient Orphan Crop -- Chapter 23. Advances and Prospects in Genomic and Functional Studies of the Aquatic Crop, Sacred Lotus -- Chapter 24. Utilising Public Resources for Fundamental Work in Underutilised and Orphan Crops.
    Abstract: This book highlights the uses for underutilized crops, presenting the state-of-the-art in terms of genome sequencing for over 30 crops, previously understudied and under-researched. In a changing climate and with significant pressure on the land, it is the ideal time to be discussing novel crops, with significant biotic and abiotic tolerances and/or rich nutrient profiles for consumers. Previously, the only species with sequenced genomes were high-profile internationally recognized crops, but in the current era genomes are being sequenced for dozens of crops, including those previously classified as underutilized, now being investigated. This book covers food crops, from fruits to tubers, and from grasses to legumes, as well as crops with non-food applications. Some of these crops have draft genomes, and others have polished genomes with extensive resequencing panels. Each chapter tells the story of an individual crop or crop group, written by experts, focusing on the genome data available, revealing more about crop domestication and genetic variation, and the current and future prospects given that this data is now becoming available. It also highlights how even small sequencing projects can provide draft genome sequences suitable for gene discovery, comparative genomics, and identification of molecular markers for understanding these crops further.
    Type of Medium: Online Resource
    Pages: XXIV, 450 p. 125 illus., 105 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031008481
    Series Statement: Compendium of Plant Genomes,
    DDC: 580
    Language: English
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  • 21
    Keywords: Botany. ; Biodiversity. ; Plant ecology. ; Conservation biology. ; Ecology . ; Plant Science. ; Biodiversity. ; Plant Ecology. ; Conservation Biology.
    Description / Table of Contents: Flowering phenology in a restinga community: seven years of study -- Dioecy: the dimorphic sexual system and pollination in restinga vegetation -- Male and female sterility in flowering plants -- Broad-scale variation of phytoplankton richness in Brazilian inland waters -- The Importance of Palynology to Taxonomy -- Ecological Palynology -- Scientific Exploration Commission (1859-1861): Freire Allemão and the invisible network of collaborators -- The former Imperial Plant Nursery of Quinta da Boa Vista -- Medicinal plants used in Quilombola communities in Piranga, State of Minas Gerais, Brazil -- From mulungu to mamulengo”: The sharing of knowledge among teachers, academic researchers and mamulengueiros (traditional puppeteers) in a participatory workshop -- Biocultural heritage through museological narrative as a way of return on research in historical ethnobotany -- Conclusion of the reflections on Aspects of Brazilian Floristic Diversity: From Botany to Traditional Communities.
    Abstract: Aspects of Brazilian Floristic Diversity: From Botany to Traditional Communities offers a unique approach in floristic diversity of the Neotropical region, specifically encompassing the Brazilian flora. This volume combines both theoretical and applied aspects of scientific making knowledge in different perspectives of Botanical Science. In this volume, botanical specialists discuss the many different approaches of taxonomic, reproductive, ecological and ethnobotanical aspects of Brazilian floristic diversity, thereby enlightening the global interest in Neotropical species, in particular those from the Brazilian territory. The book addresses relevant questions from many points of view, including anatomy, reproduction, palinology, conservation and ethnobotany, creating an in-depth perception of the flora in its complexity constitution. The book provides a comprehensive outlook on Botany Sciences, considering the history and traditional knowledge of plants, and relating it to contemporary problems and concerns of flora conservation today. With this current perspective, this book reaches a vast audience from the research lines of Botany, and encompasses a broader and interdisciplinary understanding of Aspects of Brazilian Floristic Diversity.
    Type of Medium: Online Resource
    Pages: XXIV, 268 p. 49 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031074530
    DDC: 580
    Language: English
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  • 22
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Agriculture. ; Genetics. ; Plant Science. ; Agriculture. ; Genetics and Genomics.
    Description / Table of Contents: 1. Introduction -- 2. Taxonomy and Evolution of the tribe Triticeae Dumort -- 3. Genome structure of Triticeae species -- 4. B Chromosomes -- 5. Orphan genera of the subtribe Triticineae Simmonds -- 6. Secale L -- 7. Classification of the wheat group (the genera Amblyopyrum, Aegilops, and Triticum) -- 8. Amblyopyrum (Jaub. &Spach) Eig -- 9. Aegilops L -- 10. Triticum L. -- 11. Evolution of the diploid species of the sub-tribe Triticineae -- 12. Evolution of the allopolyploid species -- 13. Evolution of wheat under cultivation -- 14. Future prospects -- 15. References. .
    Abstract: This open access book covers a century of research on wheat genetics and evolution, starting with the discovery in 1918 of the accurate number of chromosomes in wheat. We re-evaluate classical studies that are pillars of the current knowledge in light of recent genomic data in the wheat group comprising 31 species from the genera Amblyopyrum, Aegilops, Triticum, and other more distant relatives. For these species, we describe morphology, ecogeographical distribution, phylogeny as well as cytogenetic and genomic features. For crops, we also address evolution under human selection, namely pre-domestication cultivation and domestication. We re-examine the genetic and archeological evidence of where, when, and how domestication occurred. Several species are polyploids, including bread wheat which is a young allohexaploid. We discuss unique aspects of genome evolution and maintenance under polyploidization. Finally, we propose some thoughts on the future prospects of wheat improvement. As such, it can be of great interest to wheat researchers and breeders as well as to plant scientists and students interested in plant genetics, evolution, domestication, and polyploidy.
    Type of Medium: Online Resource
    Pages: XXIII, 673 p. 28 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031301759
    DDC: 580
    Language: English
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  • 23
    Keywords: Medicine Research. ; Biology Research. ; Medical education. ; Materials Microscopy. ; Anatomy. ; Cytology. ; Education Data processing. ; Biomedical Research. ; Medical Education. ; Microscopy. ; Anatomy. ; Cell Biology. ; Computers and Education.
    Description / Table of Contents: Part I. Advances in Microscopy for Visualization, Education and Healthcare Practice -- Chapter 1. Visualizing the Invisible: Microscopy and How It Affects Our Understanding of Cells and Tissues -- Chapter 2. Morphometric Image Analysis and Its Applications in Biomedicine Using Different Microscopy Modes -- Chapter 3. The Shift in Power from Conventional to Digital and Virtual Microscopy -- Chapter 4. How Visualizations Have Revolutionized Taxonomy: From Macroscopic, to Microscopic, to Genetic -- Chapter 5. Bright New World: Principles of Fluorescence and Applications in Spectroscopy and Microscopy -- Chapter 6. An Introduction to Particle Tracking Techniques with Applications in Biomedical Research -- Chapter 7. An Exploration of the Practice of CT Modalities to Evaluate Anterior Cranial Deformities in Craniosynostosis -- Part II. Anatomical and Cell Biology Education -- Chapter 8. The Use of Biomedical Imaging in Visuospatial Teaching of Anatomy -- Chapter 9. Ultrasound Imaging for Musculoskeletal Research -- Chapter 10. Skill Acquisition in Histology Education.
    Abstract: This edited book has a strong focus on advances in microscopy that straddles research, medical education and clinical practice. These advances include the shift in power from conventional to digital microscopy. The first section of this book covers imaging techniques and morphometric image analysis with its applications in biomedicine using different microscopy modes. Chapters highlight the rich development of fluorescence methods and technologies; particle tracking techniques with applications in biomedical research and nanomedicine; the way in which visualizations have revolutionized taxonomy from gross anatomy to genetics; and the psychology of perception and how it affects our understanding of cells and tissues. The book’s first section concludes by exploring the use of CT modalities to evaluate anterior deformities in craniosynostosis. In the second section of the book, chapters on anatomical and cell biology education explore the history of anatomical models and their use in educational settings. This includes examples in 3D printing and functional human anatomical models that can be created using easily available resources and the use of biomedical imaging in visuospatial teaching of anatomy; the novel use of ultrasound in medical education and practice; and skill acquisition in histology education using a flowchart called a ‘decision tree’. This book will appeal to histologists, microscopists, cell biologists, clinicians and those involved in anatomical education and biomedical visualization, as well as students in those respective fields.
    Type of Medium: Online Resource
    Pages: XIV, 228 p. 107 illus., 94 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031368509
    Series Statement: Biomedical Visualization, 2
    DDC: 610.72
    Language: English
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  • 24
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Biology Technique. ; Regenerative medicine. ; Biomedical engineering. ; Biomedical Research. ; Cell Biology. ; Biological Techniques. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Biopharmaceuticals Produced from Cultivated Mammalian Cells -- Remote Control of Mammalian Therapeutic Designer Cells -- Next generation cell engineering using microRNAs -- An Omic’s data-driven approach towards engineering mammalian cell factories and bioprocesses for biopharmaceutical production -- Redesigning spent media from cell culture bioprocess to feed new bacterial fermentations -- Monoclonal antibody glycoengineering for biopharmaceutical quality assurance -- Next-generation cell engineering platform for improving recombinant protein production in mammalian cells -- Manufacturing human pluripotent stem cells and differentiated progenitors -- Biomanufacturing of Mesenchymal Stromal Cell for Therapeutic Applications -- Process Design for hMSC Products in Stirred Tank Bioreactors -- Bio-production of Adeno-associated virus for gene therapy -- Scale-up (and scale-down) of CHO cell culture, with a focus on how to adjust the various culture parameters/setpoints across different systems from lab-scale to manufacturing-scale -- Intensified and Continuous mAb Production with Single-Use Systems -- Mathematical modelling of cell culture processes -- Model-assisted design concepts for mammalian cell culture processes -- Bioprocess monitoring and control -- Industrial Monitoring of Cell Culture.
    Abstract: This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.
    Type of Medium: Online Resource
    Pages: X, 550 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030798710
    Series Statement: Cell Engineering, 10
    DDC: 610.72
    Language: English
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  • 25
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. Lysine demethylation in pathogenesis -- Chapter 2. Targeting the LSD1/KDM1 Family of Lysine Demethylases in Cancer and Other Human Diseases -- Chapter 3. KDM2 demethylases as drug targets -- Chapter 4. Role of histone demethylase KDM3 (JMJD1) in transcriptional regulation and cancer progression -- Chapter 5. KDM4 demethylases as drug targets -- Chapter 6. KDM5 lysine demethylases in pathogenesis, from basic science discovery to the clinic -- Chapter 7. Context-dependent functions of lysine demethylases in physiology and disease -- Chapter 8. KDM7 demethylases as drug targets.
    Abstract: This book provides a comprehensive summary of our current knowledge on lysine demethylases, a class of epigenetic regulators. It takes the reader on an exciting journey spanning the past two decades, starting from the initial discovery and characterization of these enzymes and leading up to the development of their small molecule modulators. These modulators have shown promise in clinical trials and hold great potential to improve patient outcomes. The book captures the progress made in this field and highlights the significant advancements that have paved the way for potential therapeutic applications. The book covers a wide range of topics, spanning both basic biology and clinical implications associated with lysine demethylases. It offers a comprehensive historical and conceptual framework for the discovery and characterization of similar epigenetic enzymes or modulators. Chapter one serves as an introductory overview, providing insights into the general characteristics and functions of lysine demethylases. In subsequent chapters, specifically chapters two to eight, each major family of lysine demethylases is individually explored in depth. By providing in-depth insights into the functional aspects of these enzymes, the book allows readers to grasp their significance in regulating cellular processes and influencing pathogenesis. Moreover, the book goes beyond fundamental knowledge and also explores the development of diagnostic and therapeutic strategies related to lysine demethylases. It highlights the potential for utilizing these enzymes as therapeutic targets for the treatment of various diseases, including cancer and infectious diseases. Additionally, the book highlights future directions aimed at further unraveling the roles of lysine demethylases and translating these findings into the clinic.
    Type of Medium: Online Resource
    Pages: VII, 184 p. 35 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031381768
    Series Statement: Advances in Experimental Medicine and Biology, 1433
    DDC: 610.72
    Language: English
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  • 26
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Medicine Research. ; Biology Research. ; Medical education. ; Anatomy. ; Education Data processing. ; Biomedical Research. ; Medical Education. ; Anatomy. ; Computers and Education.
    Description / Table of Contents: Part I. History of Medical Illustration, Graphic Medicine, Humanizing Healthcare and Equitable Visualizations -- Chapter 1. Drawn Together: Merging the Worlds of Health and Comics Through Graphic Medicine -- Chapter 2. Medical Graphics and Graphic Medicine -- Chapter 3. Decolonising Visual Narratives in Global Health: The Case for Equitable and Ethical Imagery Use -- Chapter 4. Medical Illustration in Anatomy -- Chapter 5. Valuing Creativity in Biomedical Science Education: A Reflective Narrative -- Chapter 6. Biomedical Visualization in Embryology Education: A Scoping Review -- Chapter 7. A Framework for the Design, Production, and Evaluation of Scientific Visualizations -- Part II. Anatomical and Cell Biology Education -- Chapter 8. Palpation: The Art of Felt Anatomy -- Chapter 9. Teaching Histology with Analogies -- Chapter 10. Using the Hands for Learning Anatomy -- Chapter 11. Corporeal Pedagogy: Visualizing Anatomy Through Art, Archaeology and Medicine.
    Abstract: This book contains subjects by authors with a fresh, exciting and extensive focus within the medical humanities, offering the reader chapters which include the history of medical illustration, Graphic Medicine as a vehicle for the expression of humanistic dimensions of healthcare, equitable and ethical medical illustrations, as well as novel, art-based approaches in anatomical education. Authors consider the role of visual narratives in medical and scientific illustration, the unique affordances of the comics medium, the history of comics as a form of medical and scientific visualization, and the role of comics as didactic tools and as vehicles for the expression of the humanistic dimensions of healthcare. A chapter considers ethical and equitable implications in global healthcare practice, and highlights the work currently being undertaken to address inappropriate and problematic depictions of people in global health visualizations. This will inform the reader of emerging and current thinking about visual communication and the use of images in the public domain, as well as in the healthcare and education sectors. Novel approaches in anatomical education include the benefits of three-dimensional anatomy models made of felt, visual analogies as a method to enhance students’ learning of histology, the use of the hands for learning anatomy, and visualizing anatomy through art, archaeology and medicine. This book will appeal to readers who have an interest in the medical humanities, Graphic Medicine, and ethical medical and anatomical illustrations. These include academic and non-academic readers, medical students, medical educators, clinicians, health-care workers, as well as policy makers.
    Type of Medium: Online Resource
    Pages: XIV, 249 p. 88 illus., 81 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031390357
    Series Statement: Biomedical Visualization, 3
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Drug delivery systems. ; Genetics Research. ; Imaging systems in biology. ; Biology Technique. ; Biomedical Research. ; Drug Delivery. ; Genetics Research. ; Biological Imaging. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Editorial: Biosystems -- 2. Potential of Biotechnology in cancer management -- 3. Biosimilars: Promising and Rapidly Emerging Biotherapeutics -- 4. Applications of Nanomaterials in Medicine: Current status and future scope -- 5. Biomedical Applications of Nanofluids in Drug Delivery.
    Abstract: The book gives an insight into the theoretical background, conceptual understanding, latest developments, and applications in the field of pharmaceuticals in general and drug design, discovery, biosystems, and biomedical and drug delivery technologies in particular . Knowledge is drawn from various disciplines such as Chemistry, Biology, Material Science and Engineering, Statistics, Biomedicine, and Genetics . A host of applications like bio-imaging, novel biological agents, testing, characterization and validation of drugs, computer-based models in drug design, and application of statistical tools in data analysis, design, and development of drug delivery systems, and ecosystems are dealt with in detail. The said book undoubtedly confirms the requirements of the postgraduate students, research scholars, academicians, scientists, and researchers from the academia, pharmaceutical, biotechnology, and chemical engineering domain. The book covers a conceptual understanding of the exploration of drugs in tandem with intended uses, sound ecosystem development, and carriers for drug and supplement delivery.
    Type of Medium: Online Resource
    Pages: XX, 289 p. 58 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819952816
    DDC: 610.72
    Language: English
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  • 28
    Keywords: Botany. ; Plant diseases. ; Agriculture. ; Plant Science. ; Plant Pathology. ; Agriculture.
    Description / Table of Contents: Part 1. Organic Management of Nematodes: Paradigms and Mechanisms -- 1. Biochemical Biopesticides for Phytonematode Sustainable Management: Status and Future Prospects (Thales Lima Rocha; Vera Lucia Perussi Polez; Lívia Cristina de Souza Viol; Reinaldo Rodrigues Pimentel, Danielle Biscaia; Jadir Borges Pinheiro) -- 2. Organic Nematicides: A Green Technique and its Overview for the Nematode Disease Management (Faryad Khan, Mohammad Shariq, Mohd Asif, Taruba Ansari, Saba Fatima, Arshad Khan, Mohd Ikram, Mansoor Ahmad Siddiqui) -- 3. Nematode Management Through Compost (Fisayo Yemisi Daramola, Samuel B. Orisajo and Omorefosa Osarenkhoe Osemwegie) -- 4. Biochemical/Molecular Mechanisms Associated with Nematode Management Through Organic Amendments: A critical Review (John Fosu-Nyarko, Rhys G. R. Copeland, Sadia Iqbal, Michael G. K. Jones) -- 5. Organic By-Products in the Suppression of Plant-Parasitic Nematodes (Alixelhe Pacheco Damascena, Marylia Gabriella Silva Costa, Júlio César Antunes Ferreira, Silvia Renata Siciliano Wilcken) -- 6. Nematode Management by Humic Acid (Seenivasan Nagachandrabosea, Sankaranarayanan Chellappab, and Devrajan Kandasamya) -- 7. Conventional and Organic Management as Divergent Drivers for Plant Parasitic Nematodes (PPNs) control (Kanika Khanna, Vandana Gautam, Dhriti Kapoor, Nandni Sharma, Pooja Sharma, Tamanna Bhardwaj, Puja Ohri, Renu Bhardwaj) -- Part 2. Organic Management of Nematodes: Global Case studies and Success Stories -- 8. Plant Extracts and Their Effect on Plant-parasitic nematodes: Case Studies from Africa (Ebrahim Shokoohi) -- 9. Organic Management of the Citrus, Pine and Related Nematodes (Reza Ghaderi, Manouchehr Hosseinvand) -- 10. Organic Management of Rice Root-Knot Nematode Meloidogyne graminicola (Ziaul Haque and Mujeebur Rahman Khan) -- 11. Strategies for the Organic Management of the Root-Knot Nematode (Meloidogyne spp.) in Grapevine Under Desert Conditions in the North Coast of Peru (César Augusto Murguía Reyes) -- 12. Organic Fumigant Alternatives for Nematode Management in High-Value Crops in Florida (Johan Desaeger, Kaydene Williams, and Erin Rosskopf) -- 13. The False Root-Knot Nematode Nacobbus aberrans and its Ecological Management (Edgar Villar-Luna, Olga Gómez-Rodríguez, Hernán Villar-Luna, Liliana Aguilar-Marcelino, Laith Khalil Tawfeeq Al-Ani, and Ernesto Fernández-Herrera) -- 14. Plant Extracts, Sorghum and Crucifers Amendments and Pochonia chlamydosporia for the Management of Meloidodyne spp. and Nacobbus aberrans in Tomato and Chile Crops: the Mexican Experience (Ignacio Cid del Prado-Vera, Marco Antonio Magallanes-Tapia, Raúl Velasco-Azorsa, Arely Pérez-Espíndola) -- 15. Non-Conventional Management of Plant-Parasitic Nematodes in Musaceas Crops (Donald Riascos–Ortiz, Ana Teresa Mosquera–Espinosa, Francia Varón De Agudelo, Claudio Marcelo Gonçalves De Oliveira, Jaime Eduardo Muñoz–Florez) -- 16. Neem Cake Amendment Changes Soil Nematode Spatio-temporal Dynamics Across a Guava Orchard in the Brazilian Semiarid Region (Diego Arruda Huggins de Sá Leitão, Ana Karina dos Santos Oliveira, Douglas Barbosa Castro, Elvira Maria Régis Pedrosa).
    Abstract: The present work covers many aspects of plant nematode management using organic strategies. These range from applications of latest understandings of fundamental concepts/mechanisms of nematode control, to modern tools and techniques used in efficacy evaluation. The Volume also includes some case studies/applied aspects of organic nematode pest management. Chemical and physical control measures used for nematode management have their own implications. Against this backdrop, organic management of plant nematodes appears as a more rational and sustainable approach. However, concise information on the current topic is scarce. This book is a sincere effort to bridge this void as we aim to provide the most updated, critical and in-depth knowledge synthesized by many experts working in the field of plant nematology, worldwide.
    Type of Medium: Online Resource
    Pages: XI, 440 p. 51 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031099434
    Series Statement: Sustainability in Plant and Crop Protection, 18
    DDC: 580
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Botany. ; Biodiversity. ; Plant biotechnology. ; Plant Science. ; Biodiversity. ; Plant Biotechnology.
    Description / Table of Contents: 1. The Current Status of Population Extinction and Biodiversity Crisis of Medicinal Plants -- 2. Medicinal Plants and Bioactive Phytochemical Diversity: A Fountainhead of Potential Drugs against Human Diseases -- 3. Threats and opportunities for sustainable use of medicinal plants in Brazilian Atlantic Forest based on the knowledge of Indigenous Peoples and Local Communities -- 4. Climate Change Impact on Medicinal Plants: An Insight from the IUCN Red List Of Threatened Species -- 5. Securing Conservation Status of Paris Polyphylla, a Medicinally Important Plant of the Indian Himalayan Region -- 6. Endophytic Fungal Diversity in Solanaceous Medicinal Plants and Their Beneficial Impact -- 7. Genetic Studies on Threatened Medicinal Plants of Brazil: Mind the Gap -- 8. Medicinal Plants of North-east India: Biodiversity and Their Ethno-Medicinal Values -- 9. Strategies for Conservation and Sustainable Use of Medicinal Plants -- 10. Scientific Databases for Conservation of Medicinal Plants -- 11. International Trade of Medicinal and Aromatic Plants (MAPs) -- 12. Inventorization of Ecology, Ethnobotany and Conservation Status of Dactylorhiza hatagirea: Problems Progress and Prospects -- 13. Conservation and Sustainable Use of Medicinal Plants -- 14. Traditional Practices of Ethnomedicinal Plants in North-East Region of India and Their Conservation for Sustainable Utilization -- 15. Occurrence and Diversity of Major Naphthoquinones in Higher Plants: Their Distribution and Conservation Strategies -- 16. Astragalus fridae genetic Source,Applications, and Conservation -- 17. Tinospora cordifolia as a Potential Candidate for Health Care Of Post-Menopausal Women -- 18. The Potential Role of Medicinal Plants, Traditional Herbal Medicines and Formulations to Overcome SARS-CoV-2 Induced Health Crisis -- 19. Bioactive Compounds from Medicinal Plants and Its Therapeutic Uses in the Traditional Health Care System -- 20. In-Vitro conservation and propagation of endangered Ethno-Medicinal Orchids from the Northeast Region of India -- 21. Artificial Seed Production and Cryopreservation Technology for Conservation of Plant Germplasm with Special Reference to Medicinal Plants -- 22. Biotechnological Studies on Nasturtium Officinale (Watercress) - An Endangered Species of Significant Relevance in Medicine, Cosmetic, and Food Industries -- 23. Isatis tinctoria L. (woad) – Cultivation, Phytochemistry, Pharmacology, Biotechnology, and Utilization -- 24. Tissue Culture Techniques to Conserve Endangered Medicinal Plants with Antimicrobial and Antiviral Activities -- 25. Insights into the In Vitro Approaches for the Production of Secondary Metabolites Towards The Conservation of Medicinal Orchids -- 26. Biotechnological Approaches for Ex Situ Conservation of Medicinal Plants -- 27. Conservation of Medicinal Plants by Tissue Culture Techniques -- 28. Current Status of Metabolic Engineering of Medicinal Plants for Production of Plant-derived Secondary Metabolites -- 29. Stationary, Agitated and Bioreactor Cultures of Verbena officinalis L. (Common Vervain) - A Potential Rich Source of Bioactive Phenolic Compounds for Pharmacy, Health Food Industry and Cosmetology.
    Abstract: This contributed volume provides a comprehensive, in-depth and subject-based reviews on the current status of active ingredients, sustainable use, biodiversity and conservation of certain endangered medicinal plants. The book also explores conventional and non-conventional biotechnological interventions for their biodiversity conservation. Medicinal plants have been used in worldwide as a major source of raw material for the traditional herbal healthcare practices as well as for drug discovery and development in pharmaceutical industry. The cumulative consequences of various human activities and environmental factors cause decline in the biodiversity of medicinal plants at an unprecedented rate worldwide. Thus, the overall understanding of ecology, species and genetic diversity along with assessment of the status of different threats and their impact on medicinal plants is crucial to sustain existing biodiversity, its utilization and conservation. All the latest advancements in the biotechnological approaches for the conservation research of endangered medicinal plants and the future perspectives have been described. This book provides comprehensive reviews spreading over about 25 chapters divided in three sections. The chapters of this book are written by recognized scientists in their respective fields which are useful to students, academicians, researchers, botanists, biotechnologists, policy makers, conservationists and industries interested in biodiversity conservation and medicinal plant research for the production of secondary metabolites.
    Type of Medium: Online Resource
    Pages: XIX, 906 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811999369
    Series Statement: Sustainable Development and Biodiversity, 33
    DDC: 580
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Biology. ; Neurosciences. ; Biotechnology. ; Drug delivery systems. ; Biomedical Research. ; Biological Sciences. ; Neuroscience. ; Biotechnology. ; Drug Delivery.
    Description / Table of Contents: Chapter 1.Deciphering New Drug Targets in Alzheimer’s Disease -- Chapter 2. Novel Therapeutic Targets for Treating Alzheimer’s Disease -- Chapter 3. Modified Investigation Tools and Techniques Useful in Alzheimer’s Disease Research -- Chapter 4. Dual Specificity Tyrosine Phosphorylation Regulated Kinase1A (DYRK1A) Inhibitors: The Quest for a Disease-Modifying Treatment for Alzheimer’s Disease -- Chapter 5. β-secretase as a primary drug target of Alzheimer disease: Function, Structure, and Inhibition -- Chapter 6. Endocrine Receptors: The Potential Therapeutic Targets for Alzheimer’s -- Chapter 7. Calcium Channels as a Potential Therapeutic Target for Alzheimer’s Disease -- Chapter 8. Traversing Through the Trajectory of Pathogenic Astrocytes in Alzheimer’s Disease -- Chapter 9. Targeting Mitochondrial Dynamics as a Restorative Approach in the Treatment of Alzheimer’s Disease -- Chapter 10. Epigenetic Therapy for Alzheimer’s Disease -- Chapter 11. Exploring the Diverse Roles of GSK-3ß Kinase in Alzheimer’s Disease -- Chapter 12. Role of Target Fishing in Discovery of Novel Anti-Alzheimer’s Agents: In Silico Applications -- Chapter 13. Multi-Target Directed Ligand Approach in Anti-Alzheimer’s Drug Discovery -- Chapter 14. Investigating the Role of Tau Proteins in Alzheimer’s Disease-From Typical Functioning MAPs to Aberrant Fibrillary Deposits in the Brain -- Chapter 15. The Overview of Drugs Used in Alzheimer’s Disease and Their Molecular Targets.
    Abstract: This book explains the fundamental characteristics and biofunctionality of Alzheimer’s Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer’s Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer’s disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer’s disease treatment.
    Type of Medium: Online Resource
    Pages: XV, 381 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819926572
    DDC: 610.72
    Language: English
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  • 31
    Keywords: Botany. ; Plants. ; Botanical chemistry. ; Stress (Physiology). ; Plant Science. ; Plant Signalling. ; Plant Biochemistry. ; Plant Stress Responses.
    Description / Table of Contents: Preface -- I. Melatonin as an antioxidant -- Chapter 1. Melatonin and the metabolism of reactive oxygen species (ROS) in higher plants -- II. Melatonin, biosynthesis, plant growth, development and reproduction -- Chapter 2. Melatonin in Plants: Biosynthesis, Occurrence and Role in plants -- Chapter 3. Abiotic stress-induced modulation of melatonin biosynthesis accompanying phytohormonal crosstalk in plants -- Chapter 4. Role of melatonin in embryo, seed development and germination -- Chapter 5. Melatonin metabolism in seeds: physiological and nutritive aspects -- Chapter 6. Melatonin in plant growth and signaling -- Chapter 7. Functions and prospects of melatonin during pre-fertilization reproductive stages in plants -- Chapter 8. Melatonin and fruit ripening physiology: crosstalk with ethylene, nitric oxide, hydrogen peroxide and hydrogen sulfide -- Chapter 9. Melatonin and postharvest biology of fruits and vegetables: augmenting the endogenous molecule by exogenous application -- Chapter 10. Melatonin language in postharvest life of horticultural crops -- III. Melatonin and its signaling in biotic and abiotic stress -- Chapter 11. Melatonin-mediated regulation of biotic stress responses in plants -- Chapter 12. Emerging roles of melatonin in mitigating pathogen stress -- Chapter 13. Eco-physiological and morphological adaptive mechanisms induced by melatonin and hydrogen sulfide under abiotic stresses in plants -- Chapter 14. Melatonin in plants under UV stress conditions -- Chapter 15. Molecular physiology of melatonin induced temperature stress tolerance in plants -- Chapter 16. Melatonin-mediated salt tolerance in plants -- Chapter 17. Role of phytomelatonin in promoting ion homeostasis during salt stress -- Chapter 18. Positive regulatory role of melatonin in conferring drought resistance to plants -- Chapter 19. Potential, mechanism and molecular insight of melatonin in phytoremediation.
    Abstract: The new edited volume on phytomelatonin and its diverse roles in plants under a challenging environment shall be an important reference book with updated information and future perspectives on the involvement of this biomolecule in stress resilience in plants. Investigations on different aspects of melatonin in plants have undergone a prolific surge in the last decade. In view of such a considerable volume of investigations in melatonin, the proposed new volume will collate its role in different aspects of plants signaling, growth and metabolism. In this context, it has been important to understand its function as a stress priming molecule that executes associative synergistic relation with various other plant growth regulators (viz. nitric oxide, hydrogen sulfide, inorganic ions, and enzymes). Thus, crop management under diverse stressful environments can be better achieved by elucidating our current understanding of the role of melatonin and its interplay with various plant metabolites. The book shall provide a collation of recent advancements in genomic, transcriptomic, and metabolomic approaches to decipher the molecular mechanisms of melatonin signaling and its agronomic importance in plants. .
    Type of Medium: Online Resource
    Pages: IX, 386 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031401732
    Series Statement: Plant in Challenging Environments, 4
    DDC: 580
    Language: English
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  • 32
    Keywords: Botany. ; Agriculture Economic aspects. ; Alternative medicine. ; Pharmacology. ; Agronomy. ; Agriculture. ; Plant Science. ; Agricultural Economics. ; Complementary and Alternative Medicine. ; Pharmacology. ; Agronomy. ; Agriculture.
    Description / Table of Contents: 1. Khikeya Semy*, Ruokuonuo Kuotsu -- Ethnobotanical study of medicinal herbs used by the Naga tribals of Eastern Himalayas -- khikeyasemy@gmail.com -- 2. Ahirrao YA1, Patil MV2 and DA Patil3* -- Ethnomedicinal Use-reports of Seeds As Tapped From Herbal Vendors In North Maharashtra (India) -- dapatil_10aug@yahoo.com -- 3. Pious Soris Tresina, Murugeswaran Santhiya Selvam, Vallinayagam Sornalakshmi and Veerababu Ramasamy Mohan -- Ethnobotanical Study of Medicinal Plants Used by Traditional Healers in Grizzled Squirrel Wildlife Sanctuary -- vrmohanvoc@gmail.com -- 4. Jayalekshmi C V 1† , Reshma K Ramesh 1† , Vijai M 2† & Suresh V* -- Ethnomedicinal Plants used by Irula Tribal Settlement of Attappady in Palakkad District Kerala, India -- 5. Jayalekshmi C V 1† , Reshma S 2† & Suresh V* -- Folk Medicine Of Chittur Taluk In Palakkad District, -- 6. R. Manikandan 1 , S.P. Nithya, R. Mehala Devi -- Checklist Flora of Sunderdhunga Valley, Western Himalaya, with Emphasis on Ethno-Medicinal Plants -- 7. Pinki Gogoi, Pyonim Lungphi, A.P. Das & Ayam Victor Singh * -- Phytomedicines Used In Respiratory Diseases By Traditional Healers Of Lakhimpur & Dhemaji Districts Of Assam, India -- 8. Lydia Yeptho*, T. Ajungla -- Understanding phytomedicinal gastronomic culture of the Nagas in Nagaland, India -- 9. Ritee Basu, Sukanya Dasgupta, Spoorthy N Babu, Ayesha Noor* -- Medicinal Plants in the Indian Traditional Medicine and Current Practices -- 10. Rajeev Ranjan Kumar, Jaidev Chauhan, Vijay Kant Purohit and Pratti Prasad -- Conservation of RET Medicinal and Aromatic plants, for their Appraisal in Traditional Medicines and Current practices in Indian Himalayan Region -- 11. Neva Chaudhary 1* , Suresh K. Ghimire 2 and Ram P. Chaudhary -- Traditional Amchi Medicinal Practice in trans-Himalayas of Nepal: Conservation and Bioprospecting -- 12. Salman Majeed 1* , Muhammad Zafar 1 , Mushtaq Ahmad 1,2 , Shazia Sultana 1 , Muhammad Fethi, Ozdemir 3 , Omer Kilic 4 , Ghulam Yaseen 5 , Nabila 1 -- Appraisal of Medicinal Plants Diversity Inhabited in Deserts Areas -- 13. Karma Yeshi, Phurpa Wangchuk -- Bush Medicinal Plants of the Australian Wet Tropics and Their Biodiscovery Potential -- 14. Kausar Rashid1*, Sufiya Rashid1, Aijaz Hassan Ganie2, Irshad A. Nawchoo1, Mudasir A. Tantry3, Anzar A. Khuroo4 -- Trillium govanianum, a promising endemic medicinal herb of the Himalaya -- 15. K. Abirami, P. Revathi, K. Thenmozhi* and K. Sowndhararajan -- Comprehensive Review on Wild Basil Genus Orthosiphon of Lamiaceae -- 16. T. Soumya, P. R. Jayasree and P. R. Manish Kumar -- Zingiberaceae plants – a cornucopia of promising chemotherapeuticals for cancer cure -- 17. Nikita Patel and Ramar Krishnamurthy -- Moringa oleifera Accessions: Perspectives and application as nutraceuticals and phytomedicines -- 18. Sreeja Puthanpura Sasidharanc, Xuefei Yanga,b, Karuppusamy Arunachalama,b* -- An overview of ethnobotany, phytochemicals and pharmacological properties of Ficus species -- 19. Sunil Kumar 1 , Bikarma Singh 2,3 -- Phytochemistry and pharmacology of Catharanthus roseus (L.) G. Don and Rauvolfia serpentina (L.) Benth. ex Kurz -- 20. Naveen Dhingra* 1 , Shaligram Sharma 2 , Pratima Kumari 3 and Anand Kar 4 -- Resilience Activity of Glycyrrhiza glabra in Relation to Cancer: Chemistry and Mechanism -- 21. Reshmi Chembrammal 1 *, Aswathi Pokkadath 2 and John Ernest Thoppil 3 -- Strobilanthes: A plethora of phytomedicine -- 22. Sonia Mol Joseph* And Amala Dev A.R -- Annonaceae: Tropical medicinal plants with potential anticancer compounds: An overview -- 23. Suman Thamburaj † , Chayanika Sarma † , Anju Mariam Johnson † , Akhila Etikala † and Suresh Kumar Kalakandan* -- Biocolorant from Anisochilus carnosus: A natural food preservative -- 24. Azhagu Saravana Babu. P 1 , Vajiha Aafrin. B 2 , Sagorika Goyali 1 , Geethika. M 1 , Sugumari.V 1 , M. Sukumar -- Therapeutic properties of Nardostachys jatamansi and its applications in Post Chemotherapy induced hair loss in cancer patients -- 25. Marney Pascoli Cereda -- Phototherapeutic potential of cassava (Manihot esculenta, Crantz). -- 26. Saranya Surendran and *Raju Ramasubbu -- Phytochemistry and Pharmacological studies of Indian Cinnamomum Schaeff. -- 27. Silvy Mathew, Reshma Rajan -- Medicinal properties and population studies on Sarcostigma kleinii Wight &Arn. -- 28. Anjana Krishnan1, Jomy Joseph2 and Sudha Kalyanikutty1*, -- The Utility of Natural Mucilage from the Medicinal plant, ‘Patha’ (Cyclea peltata) as an Alternative for Solidifying Agent in Cell Growth Media -- 29. S. N. Preethamol 1 * and John E Thoppil 2 -- Secondary metabolites in Ophiorrhiza brunonis Wight &Arn. (Rubiaceae): A lead towards its anticancer potential -- 30. Kajal Chakraborty -- Marine macroalgae as a treasure house of bioactive compounds and nutraceuticals -- 31. Kapish Kapoor †1* , Priyal Jain †2 Joohee Pradhan †1* -- Plant metabolites as new leads to herbal drug discovery: Approaches and Challenges -- 32. Mudasir Maqbool 1 , Kitika Shenmar 2 , Ansab Akther 3 , Reyaz Hassan Mir 2 , Adil Farooq Wali 4* , Roohi Mohi-ud-din 5* -- Biochanin A Chemistry, Structural Modifications, and Therapeutic Applications: An Update -- 33. Biswajit Patra 1 , Nibedita Das 2 , Mohammad Zaki Shamim 3 , Tapan Kumar Mohanta 4, Bishwambhar Mishra 4 , Yugal Kishore Mohanta 5* -- Dietary Natural Polyphenols Against Bacterial and Fungal Infections: An Emerging Gravity in Health care and Food industry -- 34. Joohee Pradhan 1 * Purnima Paliwal 2† Sunita Panchawat 1† Rohini Trivedi 3† , and Devshree Gayakwad 4† -- Phyto-constituents as Potential Leads for the Development of Novel Antiepileptic Drugs -- 35. Hitesh Chopra 1 , Shabana Bibi 2 , Yugal Kishore Mohanta 3 , Sony Kumari 3 , Atif Amin Baig 4* -- Role of Polyphenols in Cardiovascular diseases -- 36. Alankar Shrivastava -- Steam Distillation: Principle And Applications For The Extraction Of Essential Oils From Plants -- 37. Durga Prasad Barik -- Factors Influencing Agrobacterium-Mediated Transformation Efficiency In Plants – A Case Study -- 38. Dr T V Binu, C B Athira -- Evaluation Of Medicinal Planttager With Reference To Its Substitute -- 39. Shipra Jha1, Shilpi Yadev2 -- Biotechnology: Production of Natural Bioactive Compounds from Leguminous Plants & Disease Management -- 40. Pawan Mulani*, Dr.Sweta S.Koka, Anirudh Padiyar, Dr. R.K. Maheshwari, Dr. G.N. Darwhekar -- Novel Ecofriendly Method Of Extraction For Fixed Oils Using Solvent Action Of Solid Solubilizers -- 41. 1Yasotha Jeyaram, 2Priya Prasannan, 1Arjun Pandian, 2*Ramasubbu Raju -- Conservation attempts of woody medicinal plants of India by Biotechnological tools -- 42. M.V Lakshmi, S. Jeyaraj, and T.S Swapna -- Conservation of endangered medicinal plants by in-vitro propagation methods -- 43. Nadia Iqbal 1* , Sidra Nisar Ahmed 2 , Urooj subhan 1 , Nageen Arif 1 , Humaira Saleem 1 , Farah Deeba 1 -- Application of biotechnology to produce plant-derived biologically important compounds -- 44. Mehmet Zeki Kocak 1 * , Mustafa Güven Kaysim 2 -- Appraisal of Medicinal Plants for Pharmacological Properties -- 45. Yuhong Zheng 1 , Xin Shi 2 , Li Fu 3* -- Pharmacological properties and tissue culture method of endangered medicinal plants -- 46. Morvarid Noormohammadi 1 , Farzad Shidfar 2* -- Natural compounds with pharmacological properties in clinical trials -- 47. Aswathi Pokkadath1, Reshmi Chembrammal2, and John Ernest Thoppil3 -- Phytopharmacological aspects of the genus Terminalia -- 48. Priyanka Soni 1 , Md. Sajid Ghufran 2 and Govinda Rao Duddukuri 3 * -- Anticancer potential of plant-derived compounds: An overview of their epigenetic mode of action -- 49. Nikita Kale -- Treatment of Cancer Using Combination of Herbal & Novel Drug Delivery System -- 50. Nisha Sam Nirmala* 1 , Navina Bala Krishnan 1 , Vaishnavi Vivekanandan 1 , Krishnaraj Thirugnanasambantham -- Anti-Inflammatory Potential Of Lead Compounds And Their Derivatives From Medicinal Plants -- 51. Tanima Bhattacharya a,b# , Debashrita Das c# , Hitesh Chopra d , Atif Amin Baig* e -- Alzheimer disease treatment using natural foods: A perspective overview -- 52. Anjali Saharan 1 , Harkiran Nehra 2 , Chander Parkash 3 , Rakesh Kumar Sindhu 4 , Inderjeet Verma 3 -- Natural products used for the treatment of an autoimmune disorder -- 53. Cristina M. Pérez Zamora 1,2*† , Carola A. Torres 1,2*† and Ana M. Gonzalez 3 -- Strategies to improve antimicrobial activity of natural products: approaches and challenges -- 54. Sinimol Thekkekkoottumughath Peethambaran1* -- Plants Described In Ayurveda With Immunomodulatory Potential -- 55. B Sumithra 1*, Sanjeeb Kumar Mandal 1, B Bishwambhar Mishra 1, Mounika KVSSN 1, Caleb Joel Raj J 1, Aishwarya CVS 1. -- Plant-derived drugs for Alzheimer’s and other neurological disorders -- 56. Afroze Naveed Basha 1 , Ramya Subramanian 2 , Kandeepan Chithan 1 , Gopinath Gurulingam, Vincent 3 , Karthigeyan Murugesan 3 , Ananthavalli Ramachandran 3 , Sivakumar Pethanan 3 , Mani, Panagal 4 , Chella Perumal Palanisamy 5* , Jayakumararaj Ramaraj 6* -- Properties and mechanism of antimicrobial agents from plant derived essential oils -- 57. Thomson Alex 1 , Alankar Shrivastava 2* , Damanpreet Kaur Lang 3 , Rakhi Khabiya 4, Sweta S. Koka 4 , Yasmin Sultana 1* -- Nanotechnological Modus Operandi For The Delivery Of Cytotoxic Phytochemicals -- 58. a Arun John and b Rinu Elizabeth Roy -- Plant Based Green Nano Particles In Cancer Diagnosis And Chemotherapy -- 59. Jeyanthi Palanivelu, R. Sai Nandhini, Kalpana Shree S, Phalguni Maity, G.S.Madhumathi, Anindita Bhar , Jeyanthi Palanivelu* -- Use Of Nanoparticles In Cancer Therapy Using Plant Resources -- 60. Md. Sajid Ghufran 1* , Priyanka Soni 2 and Govinda Rao Duddukuri 3 -- The global concern for cancer emergence and its prevention: A systematic unveiling of the present scenario -- 61. Shaikh Ajij Ahmed Makbul 1,* Sayeedur Rahman 2 -- Regularly used poisonous medicinal pl.
    Abstract: This book focuses on natural products, in particular medicinal plants and their derived products, as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery . There are several advantages for plant-derived therapeutics, including wide availability, diverse pharmacological actions, and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying the efficacy and safety of medicinal plants and phytochemicals in treating human diseases. A plethora of basic studies has also unraveled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products, and drug interactions remain to be systematically documented. Bioprospecting of Tropical Medicinal Plants represents a comprehensive analysis of natural products, mainly medicinal plants and phytochemicals. It includes detailed medicinal properties and pharmacological action from in vitro models to clinical trials. The goal is to present the readers a carefully curated collection of plant-derived natural products and their underlying molecular mechanisms.
    Type of Medium: Online Resource
    Pages: XVII, 1544 p. 150 illus., 132 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031287800
    DDC: 580
    Language: English
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  • 33
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Genetics. ; Biotechnology. ; Agriculture. ; Plant Science. ; Genetics and Genomics. ; Biotechnology. ; Agriculture.
    Description / Table of Contents: Origin of watermelon -- Whole genome sequencing of watermelon and other relevant genomic resources -- Watermelon Genetic Resources and Diversity -- Watermelon genomic resources for disease resistance -- - The NLR family of disease resistance genes in cultivated watermelon and other cucurbits: opportunities and challenges -- Mapping of economic and quality related loci in watermelon -- Genetics and genomics of fruit and quality traits of watermelon -- Genetics and genomics of host resistance and develop disease tolerant cultivars of watermelon -- Molecular and Metabolic Regulation of Nutraceuticals in Watermelon -- Challenges of Traditional breeding in watermelon.
    Abstract: This book is the first comprehensive compilation of deliberations on botany, genetic resources and diversity, classical genetics and traditional breeding, genetic transformation, and detailed enumeration on molecular maps and mapping of economic genes and QTLs, whole genome sequencing and comparative genomics in watermelon, and elucidation on functional genomics. The genomic resources for disease resistance, genomics of fruit and quality traits of watermelon, and molecular and metabolic regulation of nutraceuticals in watermelon are discussed. Mapping of quality traits, and biotic and abiotic resistance is also to be discussed. The genome draft of watermelon and application of genome editing are covered. The book contains approximately 250 pages and over 10 chapters authored by globally reputed experts on the relevant field in this crop. This book is useful to the students, teachers, and scientists in academia and relevant private companies interested in horticulture, genetics, breeding, pathology, entomology, physiology, molecular genetics and genomics, in vitro culture and genetic engineering, and structural and functional genomics. This book is also useful for seed industries. .
    Type of Medium: Online Resource
    Pages: V, 172 p. 33 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031347160
    Series Statement: Compendium of Plant Genomes,
    DDC: 580
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Biological transport. ; Cell membranes. ; Biomedical Research. ; Translational Research. ; Cell Biology. ; Membrane Trafficking.
    Description / Table of Contents: Section I. Extraction Methods -- Chapter 1. Updated Methods of Extracellular Vesicles Isolation -- Section II. Extracellular Vesicles in Cardiovascular Disease -- Chapter 2. Extracellular Vesicles and Pathological Cardiac Hypertrophy -- Chapter 3. Extracellular Vesicles and Cardiac Aging -- Chapter 4. Extracellular Vesicles and Ischemic Cardiovascular Diseases -- Chapter 5. Extracellular Vesicles and Hypertension -- Chapter 6. Extracellular Vesicles and Coronary Artery Disease -- Chapter 7. Extracellular Vesicles and Vascular Inflammation -- Chapter 8. Extracellular Vesicles and Muscle Atrophy Treatment -- Section III. Extracellular Vesicles in Metabolic Diseases -- Chapter 9. Extracellular Vesicles and Fatty Liver -- Chapter 10. Extracellular Vesicles and Obesity -- Chapter 11. Extracellular Vesicles in Bone Remodeling and Osteoporosis -- Section IV. Therapeutic Implications -- Chapter 12. Diagnosis of Extracellular Vesicles in Cardiovascular and Metabolic Diseases -- Chapter 13. Therapeutics of Extracellular Vesicles in Cardiovascular and Metabolic Diseases -- Chapter 14. Gene Therapy of Extracellular Vesicles in Cardiovascular and Metabolic Diseases -- Section V. Future Prospects -- Chapter 15. Prospective Advances of Extracellular Vesicles Investigation in Cardiovascular and Metabolic Research -- Chapter 16. Effects of Exercise on Circulating Extracellular Vesicles in Cardiovascular and Metabolic Diseases -- Chapter 17. Extracellular Vesicle Release from Platelets and their Contributions to Thrombosis.
    Abstract: This book provides the latest research progress on Extracellular vesicles (EVs) in cardiovascular and metabolic diseases. EVs are small bilayer lipid membrane vesicles released by cells and function for intercellular communication. Increasing evidence has shown that EVs play crucial roles in cardiovascular and metabolic diseases, which seriously threaten human health worldwide. The book contains four sections: 1) Extraction Methods; 2) EVs in Cardiovascular Diseases; 3) EVs in Metabolic Diseases; and 4) Therapeutic Implications. This book is useful for biologists, cardiologists, cardiovascular surgeons, endocrinologists, internists, nurses, undergraduate and graduate students in medicine and cell biology, and others interested in cardiovascular and metabolic medicine.
    Type of Medium: Online Resource
    Pages: VIII, 275 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819914432
    Series Statement: Advances in Experimental Medicine and Biology, 1418
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Microbial ecology. ; Biotic communities. ; Agriculture. ; Industrial microbiology. ; Biomedical Research. ; Microbial Ecology. ; Ecosystems. ; Agriculture. ; Industrial Microbiology.
    Abstract: The book explores the challenges and opportunities associated with high-altitude agro-ecosystems and the factors that influence them. It discusses the various indigenous agricultural practices and approaches, as well as the microbiology of mountain & hill agro-ecosystems, providing a comprehensive overview of the various factors that control the microbiome at high altitudes. The contributions examine microbiological advances, such as use of “omics” technologies for hill agriculture and environmental sustainability, and explore the use of nanotechnology for agricultural and environmental sustainability at higher altitudes. The book also describes various aspects of low-temperature microbiology in the context of high-altitude farming and environmental sustainability.
    Type of Medium: Online Resource
    Pages: XIII, 491 p. 62 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811519024
    Series Statement: Rhizosphere Biology,
    DDC: 610.72
    Language: English
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  • 36
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Medical sciences. ; Pharmacology. ; Biomedical Research. ; Cell Biology. ; Health Sciences. ; Pharmacology.
    Description / Table of Contents: Autophagy and Alzheimer’s Disease -- Autophagy and Parkinson’s Disease -- Autophagy and Motor Neuron Diseases -- Autophagy and Prion Disease -- Autophagy and Lysosome Storage Disorders -- Autophagy and Mitochondrial Encephalomyopathies -- Autophagy and Ischemic Stroke -- Autophagy and Hemorrhagic Stroke -- Autophagy and Polyglutamine Disease -- Autophagy and Epilepsy -- Autophagy in Neurodevelopmental Disorders -- Autophagy and Pituitary Adenoma -- Autophagy in Schizophrenia -- Autophagy and Hypertension -- Autophagy and Myocardial Ischemia -- Autophagy and Heart Failure -- Autophagy, Myocarditis and Cardiomyopathy -- Autophagy, Hyperlipidemia and Atherosclerosis -- Application of Autophagy in Cardiovascular Diseases -- Autophagy and Tumorigenesis -- Autophagy and Tumour Stem Cells -- Autophagy and Tumour Metastasis -- Autophagy and Tumor Cell Death -- Autophagy and Tumour Chemotherapy -- Autophagy and Tumour Radiotherapy -- Autophagy and Inflammatory Diseases -- Autophagy and Immune-related Diseases -- Autophagy and Autoimmune Diseases -- Autophagy and Bacterial Infection -- Autophagy and Viral Infection -- Autophagy and Thyroid Disease -- Autophagy and Obesity and Diabetes -- Autophagy and Obesity-related Reproductive Dysfunction -- Autophagy and Acute Kidney Injury -- Autophagy and Glomerular Diseases -- Autophagy and Diabetic Nephropathy -- Autophagy and Liver Diseases -- Autophagy and Gastrointestinal Diseases -- Chronic Obstructive Pulmonary Disease and Autophagy -- Autophagy and Pulmonary Fibrosis -- Asthma and Autophagy -- Autophagy and Other respiratory diseases -- Autophagy and Leukemia -- Autophagy and Lymphoma -- Autophagy and Myeloma -- The Function and Mechanisms of Autophagy in Traumatic Brain Injury -- The Function and Mechanisms of Autophagy in Spinal Cord Injury -- The Function and Mechanisms of Autophagy in Trauma of Other Parts of the Body -- The Prospects of Therapeutic Potential and Drug Development Targeting Autophagy in Cancer -- Progress of Anti-aging Drugs Targeting Autophagy -- Drug Development and Treatment of Autophagy in Other Diseases -- Systems Biology Approaches in Autophagy Research -- Natural Product Regulates Autophagy in Cancer -- Regulation of Autophagy in Neurodegenerative Diseases by Natural Products -- Regulation of Autophagy in Cardiovascular Diseases by Natural Products.
    Abstract: This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine.
    Type of Medium: Online Resource
    Pages: XXXVI, 736 p. 50 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811542725
    Series Statement: Advances in Experimental Medicine and Biology, 1207
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Cancer. ; Technology Sociological aspects. ; Genomics. ; Biomedical Research. ; Cancer Biology. ; Emerging Technologies. ; Genomics.
    Description / Table of Contents: Chapter 1. Introduction to emerging technologies in biomedical sciences -- Chapter 2. Bioprospecting : boon or curse -- Chapter 3. Growing need for interdisciplinary biomedical research -- Chapter 4. Interplay between theory and experiment : a future approach for biomedical research -- Chapter 5.past, present and future perspectives of biomedical innovation in india -- Chapter 6. Systems biology approaches to study disease comorbidities -- Chapter 7. Bioinformatics the interactome of multidisciplinary approaches -- Chapter 8. Role of artificial intelligence in diagnosis of infectious diseases -- Chapter 9. Dna digital data storage breakthroughs in biomedical research. Chapter 10. Biomedical applications cloud-based iot -- Chapter 11. Next generation sequencing in cancer research -- Chapter 12. Crispr: genome editing and beyond -- Chapter 13. Omics in tuberculosis diagnosis : today and tomorrow -- Chapter 14. Advances in proteomic approaches for chronic kidney disease -- Chapter 15. 3 d bioprinting of tissues and organs : a new paradigm in regenerative medicine and biomedical engineering -- Chapter 16. Virtual planning, rapid prototyping and 3-d printing in orthopedic surgery -- Chapter 17. Tissue chips: contemporary applications and advancementstissue chips: contemporary applications and advancements -- Chapter 18. Flow cytometry for measuring neutrophil function -- Chapter 19. Flow cytometer for understanding genome size variation among medicinal herbs and non-edible oil trees of northeast india -- Chapter 20. Raman spectroscopy applications for bacterial detection -- Chapter 21. Microfluidic point-of-care diagnostic devices: a contemporary relevance. Chapter 22. Fluorescent dots for breast cancer management -- Chapter 23. Molecular mimicry : unravelling the role of autoantibodies in autoimmune diseases and infertility -- Chapter 24. Strategies of vaccine development -- Chapter 25. Preclinical models of intimal hyperplasia and restenosis to predict clinical events and develop novel therapies -- Chapter 26. Sphingolipids : a roadmap from biomarker identification to clinical application -- Chapter 27. Future of gastrointestinal endoscopy -- Chapter 28. Beating heart in a box : the future of cardiac transplant -- Chapter 29. The journey of coronary stent technology -- Chapter 30. Materiovigilance in clinical surgery.
    Abstract: This book, which is the first volume of Biomedical Translational Research, summarizes emerging technologies in healthcare. The book reviews the advancements in biomedical sciences in genomics, immunology, stem cell, tissue engineering, nanotechnology, computational and structural biology, biomedical engineering, and telemedicine biology. The book highlights the applications of artificial intelligence in the diagnosis of infectious diseases and examines the role of system biology approaches for understanding human complexity, variability, and its influence on health and diseases. It presents the applications of flow cytometry in monitoring the progression and treatment of disease. It covers emerging technologies in cancer research, including CRISPR-Cas9, NGS, and nanotechnology. This book is a useful source of information for clinical researchers, basic scientists, biomedical engineers, and computational biologists.
    Type of Medium: Online Resource
    Pages: XIII, 505 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811643453
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Bioinformatics. ; Cancer. ; Biomedical Research. ; Bioinformatics. ; Cancer Biology.
    Description / Table of Contents: Values of single-cell sequencing and methylation in molecular diagnosis and therapy -- Single-cell sequencing in human diseases -- Single-cell sequencing of T cell receptors: A perspective on the technological development and translational application -- DNA Methylation in pulmonary fibrosis -- Molecular regulation and clinical significance of caveolin-1 methylation in chronic lung diseases -- Research advances on DNA methylation in idiopathic pulmonary fibrosis -- DNA Methylation in Chronic Obstructive Pulmonary Disease -- Single cell sequencing: a new dimension in cancer diagnosis -- The Role of Methylation in the CpG Island of the ARHI Promoter Region in Cancers -- Clinical Significance of P16 Gene Methylation in Lung Cancer -- Application of single-cell RNA sequencing in pancreatic cancer and the endocrine pancreas -- Single Cell Sequencing in GU Malignancies -- PI3K Isoform-Selective Inhibitors in Cancer -- Single cell RNA sequencing in human disease: Renal, pancreatic, and viral diseases -- Single-cell sequencing in human genital infections -- PI3kinase Inhibitors in Thrombosis and Cardiovascular Disease -- Use of single-cell microfluidic technology towards therapeutic antibody discovery from single B cells.
    Abstract: With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients.
    Type of Medium: Online Resource
    Pages: VIII, 247 p. 117 illus., 114 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811544941
    Series Statement: Advances in Experimental Medicine and Biology, 1255
    DDC: 610.72
    Language: English
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  • 39
    Keywords: Medicine Research. ; Biology Research. ; Therapeutics. ; Medical informatics. ; Translational Research. ; Therapeutics. ; Health Informatics.
    Description / Table of Contents: Introduction: The importance of regionalized management of medicine -- Alcohol use disorders -- Public-private partnerships management in health care: The Portuguese experience -- Management of Clinical Precision Medicine -- Artificial Intelligence in medical management -- Advanced Demand Forecasting and Inventory Management Methods in Hospital Pharmacy -- Clinical Application of Cell-Based Therapies Opportunities and Challenges -- Management of Next-Generation Sequencing (NGS) in Precision Medicine -- Exploration on the Reform of County Medical Integration -- The Regionalization of Medical Management: The Practice and Exploration of Established Fudan-Minhang Medical Alliance -- Bed-occupancy management and hospital planning: a handbook -- Management of severe childhood pneumonia in low resource setting -- The role of mitochondrial-targeted antioxidant, MitoQ, in neurodegenerative disease -- Progression of mitochondria research for clinical potentials -- DNA methylation in pulmonary inflammatory diseases -- Synthetic lethality and lung cancer.
    Abstract: The Book mainly focuses on various aspects of regionalized management of medicine, related with updates of new biotechnology, application of therapeutic strategy, and understanding of disease-associated molecular mechanisms. The book also discusses how medical informatics, systems analysis, database sharing, and artificial intelligent can be applied for improving the quality of hospital managements, disease therapies, regional collaborations, and medical services. This book serves as a professional reference book to clinicians and experts who are interested in medical informatics and artificial intelligence for diseases therapies and therapeutic strategy, better systems analysis and database sharing, and more efficient regional collaborations and medical services.
    Type of Medium: Online Resource
    Pages: X, 226 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811678936
    Series Statement: Translational Bioinformatics, 17
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Biomedical Research. ; Medical Genetics. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. General Overview of the Origins and Pathology of Ovarian Cancer -- Chapter 2_An Introduction to the Current Management of Ovarian Cancer in the Era of Precision Oncology -- Chapter 3_The Hallmarks of Ovarian Cancer: Actionable Genetics, Targetable Pathways and Predictive Biomarkers -- Chapter 4_Genetic Alterations in Ovarian Cancer as Prognostic and Predictive Biomarkers of Therapy Response and Surgical Outcomes -- Chapter 5_The Emergence of Circulating Tumor DNA in the Management of Ovarian Cancer -- Chapter 6_Proteomic Biomarkers for Early Detection and Patients’ Stratification in Ovarian Cancer -- Chapter 7_Cutting-edge Technologies and Ovarian Cancer.
    Abstract: This book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. The initial chapter discusses our current understanding of the origin, development, progression and tumorigenesis of ovarian cancer. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer. The book then reviews the role of deep molecular and cellular profiling to overcome challenges that are associated with the treatment of ovarian cancer. It explores the use of genome-wide association analysis to identify genetic variants for the evaluation of ovarian carcinoma risk and prognostic prediction. Lastly, it highlights various diagnostic and prognostic ovarian cancer biomarkers for the development of molecular-targeted therapy.
    Type of Medium: Online Resource
    Pages: XV, 229 p. 9 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811618734
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Drugs Design. ; Pharmaceutical chemistry. ; Genomics. ; Bioinformatics. ; Biomedical Research. ; Structure-Based Drug Design. ; Pharmaceutics. ; Genomics. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Emerging Technologies : Gateway to Understand Molecular Insight of Diseases, Newer Drugs, Their Design and Targeting -- Chapter 2. Polypharmacology: New Paradigms in Drug Development -- Chapter 3. Drug Repurposing in Biomedical Research : Benefits and Challenges -- Chapter 4. Computational Methods for Drug Repurposing -- Chapter 5. Genomic Approaches for Drug Repositioning -- Chapter 6. Organ-On-A- Chip: Novel in-Vitro Model For Drug Discovery -- Chapter 7. Precision Radiomolecular Oncology: Challenging the Classical Statistical Evidence Based Medicine -- Chapter 8. Drug Repositioning of the Phenylpiperazine Derivative Naftopidil in Prostate Cancer Treatment -- Chapter 9. Biomarker Based Drug Discovery and Reverse Translational Approach -- Chapter 10. Nanotechnology in Dentistry -- Chapter 11. Nanoparticles a Potential Breakthrough in Counteracting Multidrug-Resistant Bacterial Infections: A Holistic View on Underlying Mechanisms and Antibacterial Properties -- Chapter 12. Emerging Role of Cannabinoid System Modulators in Treatment of Cancer -- Chapter 13. Nanodrugs : A Futuristic Approach for Treating Nephrolithiasis -- Chapter 14. Lipo Dermaceuticals : Technological Transformation -- Chapter 15. The Importance of Drug Dose Adjustment in Elderly Patients with Special Considerations for Patients on Diverse Co-Medications and Antidepressants -- Chapter 16. Role of Microfluidics and Nano Fluidics in Managing CAD -- Chapter 17. Targeted Gene Delivery Through Magnetofection: The New Face of Medicine -- Chapter 18. Qbd-Steered Systematic Development of Drug Delivery Nanoconstructs : Vital Precepts, Retrospect and Prospects -- Chapter 19. Nanoemulsions: A Potential Advanced Nanocarrier Platform for Herbal Drug Delivery -- Chapter 20. Sirna Encapsulated Nanoparticles for Targeting Dorsal Root Ganglion (Drg) in Diabetic Neuropathic Pain -- Chapter 21. EGFR Targeted Quinazoline Clubbed Heterocycles as Anti-Cancer Agents. Chapter 22. Therapeutic Human Monoclonal Antibodies -- Chapter 23. Hydroxyapatites and Their Biomedical Applications -- Chapter 24. Recent Progress in Applications of Magnetic Nanoparticles in Medicine: A Review -- Chapter 25. Chimeric Antigen Receptor T-Cell Therapy: A Cutting Edge Therapy for Multiple Myeloma -- Chapter 26. Nanoparticles-Associated Lipopeptides: A New Class of Antimicrobials -- Chapter 27. Antimicrobial Applications of Engineered Metal-Based Nanomaterials -- Chapter 28. Strengthening Immunity-Ayurveda & Medicinal Plants -- Chapter 29. The Pathophysiology of Liver Disorders and Pharmacotherapy Options with Special Reference to Traditional Herbal Medicines: A Comprehensive Review -- Chapter 30. Polymeric Vehicles for Controlled Delivery of Ayurvedic Drugs for Wound Management.
    Abstract: This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents.
    Type of Medium: Online Resource
    Pages: XII, 599 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811692321
    DDC: 610.72
    Language: English
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    Keywords: Botany. ; Agriculture. ; Genetics. ; Biotechnology. ; Plant Science. ; Agriculture. ; Genetics and Genomics. ; Biotechnology.
    Description / Table of Contents: Chapter 1: Breeding Field Crops – History, Current Status And Introspections -- Chapter 2: Wheat Breeding -- Chapter 3: Rice Breeding -- Chapter 4: Maize Breeding -- Chapter 5: Barley Breeding -- Chapter 6: Pearl Millet Breeding. Chapter 7: Sorghum Breeding. Chapter 8: Small Millets Breeding -- Chapter 9: Sugarcane Breeding -- Chapter 10: Jute Breeding -- Chapter 11: Cotton Breeding -- Chapter 12: Maintenance Breeding Of Pusa Basmati Varieties -- Chapter 13: Maintenance Breeding -- Chapter 14: Efficient Breeding Of Crop Plants -- Chapter 15: Brassica Breeding -- Chapter 16: Groundnut Breeding -- Chapter 17: Soybean Breeding -- Chapter 18: Castor Breeding -- Chapter 19: Sunflower Breeding -- Chapter 20: Chickpea Breeding -- Chapter 21: Pigeonpea Breeding -- Chapter 22: Mungbean Breeding -- Chapter 23: Urdbean Breeding -- Chapter 24: Lentil Breeding -- Chapter 25: Fieldpea Breeding -- Chapter 26: Lathyrus Breeding.
    Abstract: This book is an advanced textbook and a reference book for the post-graduate plant-breeding students and the plant breeders. It consolidates fundamental concepts and also the latest advances in plant-breeding practices including development in crop genomics. It contains crop wise explanation on origin, reproduction, genetics of yield contributing traits, biotic and abiotic stresses, nutritional improvement and crop specific plant-breeding procedures and techniques. The chapters are planned to describe crop-focused breeding procedure for the major crop plants as per their economic importance. The recent developments in breeding of field crops have been reported. The recent progress made in mapping traits of economic importance has been critically reviewed for each crop. The progress made in markers assisted selected in few crops has been summarized. This book bridges the knowledge gap and bring to the researchers and students information on modern breeding tools for developing biotic and abiotic stress tolerant, climate resilient and micronutrient rich varieties of field crops. The chapters in book are contributed by experienced Plant Breeders.
    Type of Medium: Online Resource
    Pages: XIV, 1389 p. 109 illus., 98 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811692574
    DDC: 580
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Analytical chemistry. ; Toxicology. ; Biomedical Research. ; Analytical Chemistry. ; Toxicology.
    Description / Table of Contents: Microplastic research publications from 1991 to 2020 -- Characterization and toxicology of microplastics in soils, water and air -- Coral feeding behavior on microplastics -- Microplastics remediation in the aqueous environment -- Removal of environmental microplastics by advanced oxidation processes -- Techniques for removal and degradation of microplastics -- Occurrence and removal of microplastics in wastewater treatment plants -- Microplastic souces, transport, exposure, analysis and removal -- Airborne microplastics in outdoor and indoor environments -- Nanoplastic sources, characterization, ecological impact, remediation and policies -- Microplastics in soil-plant systems.
    Abstract: Microplastics and nanoplastics have been recently found in most environmental media and in living organisms, thus representing a serious health concern of yet poorly known adverse consequences. This book summarizes recent findings on the sources, behavior, transformation, toxicity and remediation of microplastics, with focus on soils, water, wastewater, air, soils, plants and corals. Advanced methods for sampling, characterization, removal and degradation of microplastics.
    Type of Medium: Online Resource
    Pages: VIII, 282 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031363511
    Series Statement: Environmental Chemistry for a Sustainable World, 73
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Forensic sciences. ; Toxicology. ; Biomedical Research. ; Forensic Science. ; Toxicology.
    Description / Table of Contents: 1 Forensic Dna Analysis: A Powerful Investigative Tool -- 2 “Crime Scene Management Within Forensic Science-Forensic Techniques For Criminal Investigations -- 3 Small Size, Big Impact: Insects For Cadaver Examination -- 4 Dermatoglyphics & Other Impressions: Deciphering The Potential Of A Unique Hominid Niche -- 5 Postmortem Toxicology: A facet of drugs of expedites crimes -- 6 Forensic Biology: A Passport For Biological Evidence -- 7 Sexual offences: Recent methods of Investigation -- 8 Investigation Of Disaster Victim Identification -- 9 Review On Clinical Forensic Medicine -- 10 Firearms and Ammunitions: A sentient approach in criminal investigation -- 11 Digital and Cyber Forensics: A Contemporary evolution in Forensic Sciences -- 12 Fire Investigation: Arson Or Accidental -- 13 Psychological Evaluations: An Indoor game of Criminal Minds -- 14 Competence of Evidences: A Pragmatic Approach in Court of Law -- 15 Penology: A friend or foe for criminal justice system -- 16 Chain Of Custody: Scaling The Investigation To The Event. .
    Abstract: This book, the second volume of Crime Scene Management in Forensic Sciences, reviews the role and impact of forensic evidence in criminal investigations. It also addresses the importance of post mortem examination in criminal cases. The book investigates the use of insects and arthropods to estimate post mortem intervals during forensic investigations. Further, it discusses the physiological effects of xenobiotics at the time of death, based on their concentration and distribution in the body at autopsy. Importantly, it also discusses digital forensic investigation, which can be used for the analysis of digital evidence produced at a court of law. Lastly, it defines the structure and legal framework of these forensic evidences for the effective administration of the criminal justice system. It is an excellent source of information for forensics scientists and legal professionals.
    Type of Medium: Online Resource
    Pages: VIII, 418 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811666834
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Research Methodology. ; Clinical medicine Research. ; Biomedical Research. ; Research Skills. ; Clinical Research.
    Description / Table of Contents: Section I: Understanding Grant Writing: What is your Aim (Ambition-Interest-Mission), and what you want to do -- What is a grant? How to prepare for writing a grant proposal application -- Funders Perspective: What the funding body expects from researchers? -- Funding organizations for science and healthcare -- Obtaining letters of support -- Section II: The process for grant writing: Writing a Grant Proposal for a Single Centre Study: step-by-step approach -- Budgeting the project-detailing the required funding and expenditure -- Proving the competency of the researcher and the adequacy of the infrastructure to carry out the research -- Agreement and MOU – ethical and legal aspects of funding for healthcare research -- Write an impressive cover page (Covering letter) and abstract for the grant proposal application -- Surveillance plan and site visit – Roles and rights of the researcher and the funding agency -- Sources of funding and acknowledgment – Good Clinical Practice Guidelines -- Writing a grant proposal for a Collaborative study -- Checklist for grant proposal – Mandatory elements -- Tips for improvising the chance of getting the grant -- Dealing with The Rejected Grant Proposal- Learning From The Mistakes -- Section III: Grant writing for specific regional funding organizations: Preparing a grant proposal for medical research in the UK -- Preparing a grant proposal for the USA -- Preparing a Grant Proposal for Australia -- Proposal Writing for Grant Application in Malaysia -- Grant writing for other Asian countries.
    Abstract: Conducting research requires resources to meet the research need. The resources in the research institutes/ centers are often inadequate, limiting the research outcome. Research grants help overcome those limitations and help the researchers carry out quality research without any restriction. Grant proposal writing is an essential skill to be mastered by every researcher. However, the majority of the medical schools, except the few research institutes, do not have a structured learning module for obtaining grants. On most occasions, the skill of writing grant proposals goes by self-learning. For students, it is burdening due to the tremendous time consumed to learn the craft of writing the grant proposal and the exhausting clinical and academic work. This book is carefully prepared to keep in mind the difficulties faced by the young researchers and the students concerning choosing a funding agency, grant makers' expectations, budgeting, surveillance and site visits, rights of the researcher and the funding agency, and ethical and legal aspects of obtaining the grant. The book also covers the alternate plan for partial funding or interruption of the financing, reporting the source of funding and acknowledgment, good clinical practice guidelines, and dealing with the rejected grant proposal. The research projects are often dropped or modified extensively due to the limited resources in the existing facility. The researchers are forced to compromise the research objective due to expensive requirements. There is a shortage of awareness regarding the availability of funding and grant for the conduct of research. Even if the researchers are aware of obtaining the financing, there is a lack of training in grant proposal writing, which is essential in getting the research funding. This book on grant proposal writing for medical and healthcare professionals covers such difficulties and deficiencies. It will provide complete companionship from knowing the funding agency to obtaining the grant. .
    Type of Medium: Online Resource
    Pages: XX, 247 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811970184
    DDC: 610.72
    Language: English
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  • 46
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Human physiology. ; Medical sciences. ; Life sciences. ; Biomedical Research. ; Human Physiology. ; Health Sciences. ; Life Sciences.
    Description / Table of Contents: Part I What is Molecular Hydrogen Medicine? -- Chapter 1 The power of hydrogen molecules uncovered -- Chapter 2 Development of Molecular Hydrogen Medicine -- Chapter 3 From the front-line of research – Interviews -- Chapter 4 Physiological effects of the hydrogen molecule -- Chapter 5 Some fundamental properties of hydrogen and water -- Chapter 6 Functions of heavy water in living organisms -- Chapter 7 The future of Molecular Hydrogen Medicine -- Part II Tracing the History of Life and Hydrogen -- Chapter 8 The genesis of life in the world of hydrogen, Eons ago- Chapter 9 Drastic changes of living organisms in the oxygen age -- Chapter 10 Since the appearance of humans.
    Abstract: This book provides a comprehensive account of the current status of molecular hydrogen medicine, a young field that emerged with the discovery that inhalation of hydrogen gas leads to the elimination of harmful reactive oxygen species in rats. Various physiologic effects have since been demonstrated, and possible medical applications identified. Numerous clinical projects have now been undertaken, yielding startling results. Despite this, molecular hydrogen medicine remains underappreciated among the medical community at large. The author aims to rectify this situation by fairly but critically evaluating the potential clinical benefits based on the latest scientific research. In addition, the observed physiological effects of hydrogen gas are considered within the broad context of the evolution of life on earth, offering new perspectives and helping to place molecular hydrogen medicine legitimately within the framework of life sciences. Written in an accessible manner, the book will be of value to students, researchers, clinicians, and the general public.
    Type of Medium: Online Resource
    Pages: XI, 179 p. 89 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811571572
    DDC: 610.72
    Language: English
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  • 47
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Diagnosis. ; Molecular biology. ; Cancer. ; Biomedical Research. ; Clinical Genetics. ; Diagnosis. ; Molecular Biology. ; Cancer Biology.
    Description / Table of Contents: Chapter 1. Age-Rage Stress In The Pathophysiology Of Atherosclerosis And Its Treatment -- Chapter 2. Stem Cells In Dermatology: What The Future May Hold -- Chapter 3. Current Advances And Future Avenues In Endocrinology -- Chapter 4. Autologous Conditioned Serum In Lumbar And Cervical Radiculopathy: A Systematic Review -- Chapter 5. Bench To Bedside In Ophthalmology -- Chapter 6. Rapid Eye Movement In Sleep And Dream Sleep -- Chapter 7. Novel Cellular-Stress Models With Implications In Understanding And Treating Ent Pathologies -- Chapter 8. Respiratory Disorders : Contemporary Issues In 2020 -- Chapter 9. Discovery Of Hepatitis Viruses And Two Nobel Prizes : A Tale Of Observations Serendipity Collaboration Research Institute Inter Predated And Game Changing Innovation. Chapter 10. Conventional And Modern Approaches For Clinical And Laboratory Diagnosis Of Tuberculosis -- Chapter 11. Gut Microbes In Cardiovascular Diseases -- Chapter 12. Heart Failure – Future Perspectives -- Chapter 13. IL-10 : A Key Molecular In The Mitigation Of Heart Failure -- Chapter 14. Gene Therapy In Liver Disease : Challenges And Outcomes -- Chapter 15. Interrupting Crystal To Calculus Conversion : The Future Of Research In Urolithiasis -- Chapter 16. Stem Cells – Medical Marvel In Management Of Kidney Diseases -- Chapter 17. Deciphering The Code Of Male Infertility : Genetic Tests, Counselling And Molecular Basis Of Spermatogenic Failure -- Chapter 18. Translational Epidemiology In Cancer Research : The Less Travelled Path -- Chapter 19. Adenosine Pathway In Genitourinary Malignancies: A Promising Immunotherapeutic Target -- Chapter 20. Immune Checkpoint Inhibitors In Cancer Therapy: A Ray Of Hope -- Chapter 21. Recent Developments In The Immunotherapeutic Approaches For Cancer Treatment. Chapter 22. Thrombotic Complications In Women : Risks And Prevention -- Chapter 23. Biomedical Science And Women Health -- Chapter 24. Advances In The Role Of Macronutrients In Human Health And Diseases.
    Abstract: The second volume of the Biomedical translational research discusses advancements in biomedical research for understanding the pathophysiology of various diseases towards improving diagnosis and treatment. It presents the integration of molecular-based technologies, clinical genomics, and medical informatics to improve diagnostic and treatment strategies. Further, the book reviews molecular genomics approaches for diagnosis and managing tuberculosis. It also covers the innovative strategies for cancer treatment through targeting metabolic pathways, tumor microenvironment, cancer stem cells, and immune cells. It also illuminates novel strategies for heart failure diagnosis and therapeutic approaches for the treatment of heart failure. It discusses improvements in translational research for discovery of new diagnostic tests, identifying novel biomarkers and drugable targets, and predicting optimal treatments based on understanding the underlying molecular basis of the disease. Lastly, it reviews the preclinical models of restenosis and their application and limitation in the evaluation of device-based interventional technologies for the treatment of coronary artery diseases.
    Type of Medium: Online Resource
    Pages: XIV, 491 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811688454
    DDC: 610.72
    Language: English
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  • 48
    Keywords: Botany. ; Biology Technique. ; Biotechnology. ; Plant Science. ; Biological Techniques. ; Biotechnology.
    Description / Table of Contents: Chapter 1 Science and philosophy -- Chapter 2 Student’s proposal, dissertation, or thesis -- Chapter 3 Research integrity and publication ethics -- Chapter 4 Good Research Practices -- Chapter 5 Publication 101 -- Chapter 7 Lessons learned from Nature’s reports -- Chapter 8 Success can be learned.
    Abstract: This monograph offers a comprehensive guide to good research practices and mindsets, covering a wide range of topics across 8 chapters. Readers will find numerous themes and strategies that can help them develop their research skills and achieve their objectives, from effective proposal writing to stress management and upskilling. This book explains the purpose, process, tips, and mistakes of writing proposals, theses, articles, and reviews in clear and straightforward language, allowing readers to develop good research plans. By applying the advice and insights offered in this book, students and researchers can improve the quality of their work, cultivate research integrity, and develop good publication plans, write well, and reduce rejection rates. Research outputs will be more likely to be of high quality if students and researchers are encouraged to cultivate these pieces of advice. The focus of the book is not solely on the outcomes of research. Rather, it also delves into mindset, habits, adaptability, time management, stress management, recent tools for upskilling, planning, and execution. Throughout the book, the author seeks to instill a growth mindset in the readers, encouraging them to develop positive research habits and behaviors. KPIs, particularly publications, shall not be used as a reason to erode research integrity and ethnicity; therefore, plagiarism, self-citation, falsifying data, exaggerating findings, authorship in publications, the use of AI tools, CRediT, and COPE are discussed. This book contains interviews with high-profile researchers, top management at institutions, policy advisers, etc., whose opinions and advice the readers will find valuable. Overall, this all-in-one guide is an essential resource for postgraduate students, post-doctoral fellows, and academics who are struggling to find a survival strategy in the rapidly changing research environment. The book assists readers in developing right mindset, planning their research and publications, and in achieving their predetermined objectives. .
    Type of Medium: Online Resource
    Pages: XXIII, 241 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819928125
    DDC: 580
    Language: English
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  • 49
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Proteins. ; Biomaterials. ; Nanomedicine. ; Biomedical engineering. ; Biomedical Research. ; Biomaterials-Proteins. ; Nanomedicine and Nanotoxicology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Part 1 -- 1 Interactions between the physiological environment and titanium-based implant materials – from understanding to control -- 2 Nanoscale surface Engineering and Characterization of Biomaterial -- 3 Progress of Nanotechnology-based Detection and Treatment of Alzheimer’s Disease Biomarkers -- 4 Biomaterials: Types and Applications -- Part 2 -- 5 Additive Manufacturing of Ti and its alloy-based Bioimplants for Orthopaedic Applications -- 6 Physico-chemical Modifications of Magnesium and Alloys for Biomedical Applications -- 7 Metallic Foams in Bone Tissue Engineering -- 8 Surface modification of metallic biomaterials for cardiovascular cells regulation and biocompatibility improvement -- 9 Advancement of spinel ferrites for biomedical application -- Part 3 -- 10 Functionalized 3D bioactive polymeric materials in tissue engineering and regenerative medicine -- 11 Polymer matrixes used in wound healing applications. 12 Conductive Polymers for Cardiovascular Applications -- 13 Engineered polymeric materials/nanomaterials for growth factor/drug delivery in bone tissue engineering applications -- 14 Surface engineering of polymeric materials for bone tissue engineering -- 15 Antibacterial Surface Modification to Prevent Biofilm Formation on Polymeric Biomaterials -- 16 Polymer Surface Engineering in the Food Packaging Industry -- 17 Polymeric Membranes in Waste-water Treatment -- 18 Functionalized Fluoropolymer Membrane for Fuel Cell Applications -- Part 4 -- 19 Bioceramics for Biomedical Applications -- 20 Applications of nanomaterials in the textile industry -- 21 Properties and characterization of advanced composite materials -- 22 Properties and characterization of advanced composite materials -- 23 Nano composites application in sewage treatment and degradation of persistent pesticides used in agriculture -- 24 Biomimetic Mineralization of Electrospun PCL based Composite Nanofibrous Scaffold for hard tissue Engineering. .
    Abstract: This book provides a comprehensive overview of the latest advances in a wide range of biomaterials for the development of smart and advanced functional materials. It discusses the fundamentals of bio-interfacial interactions and the surface engineering of emerging biomaterials like metals and alloys, polymers, ceramics, and composites/nanocomposites. In turn, the book addresses the latest techniques and approaches to engineering material surfaces/interfaces in, e.g., implants, tissue engineering, drug delivery, antifouling, and dentistry. Lastly, it summarizes various challenges in the design and development of novel biomaterials. Given its scope, it offers a valuable source of information for students, academics, physicians and particularly researchers from diverse disciplines such as material science and engineering, polymer engineering, biotechnology, bioengineering, chemistry, chemical engineering, nanotechnology, and biomedical engineering for various commercial and scientific applications.
    Type of Medium: Online Resource
    Pages: X, 704 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811636677
    DDC: 610.72
    Language: English
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  • 50
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Nanobiotechnology. ; Biomedical Research. ; Cell Biology. ; Nanobiotechnology.
    Description / Table of Contents: Chapter 1. Nanomaterials and Stem Cells for Bone Tissue Engineering -- Chapter 2. The Application of Nanomaterial in Skeletal Muscle Regeneration -- Chapter 3. Application of Nanomaterials in Neurodegenerative Diseases -- Chapter 4. Application of Nano Drug Delivery Systems in Inhibition of Tumors and Cancer Stem Cells -- Chapter 5. The Application and Problems of Tetrahedral Framework Nucleic Acids as a Drug Carrier in Biomedicine Fields -- Chapter 6. Research Progress on Antibacterial Application with Nucleic Acid and Nucleic Acid Materials -- Chapter 7. The Application of DNA Nanostructures in Vaccine Technology.-.
    Abstract: This book aims to comprehensively summarize the current research status of nanomaterials and cell biology. It highlights the biological effects and biomedical applications of nanomaterials for specific diseases, bone tissue engineering, and skeletal muscle regeneration. It also provides the details of the biomedical applications of nucleic acid nanomaterials in drug delivery carriers, antimicrobial therapy, vaccine, and neurodegenerative diseases. Therefore, this book renders the audience a better understanding of nanomaterials along with the diverse applications in the cell biology field from recent works to perspectives.
    Type of Medium: Online Resource
    Pages: IX, 219 p. 13 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811626661
    DDC: 610.72
    Language: English
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  • 51
    Keywords: Medicine Research. ; Biology Research. ; Statistics . ; Biometry. ; Biomedical Research. ; Applied Statistics. ; Biostatistics.
    Description / Table of Contents: Design of Clinical Research and its Practical Approach -- Advanced Design of Experiment Approach to Clinical and Medical Research -- Random Forest and Concept of Decision Tree Model -- Application of Machine Learning in Medical Research -- Statistical Genetic and its Application in Drug Trail -- Statistical Implications for Estimation of Genetic Traits in Human Vaccine Trail -- Statistical Implications and its Practical Approach to Research Methodology -- Statistical Models Approach to Life Threatened Diseases -- Meta Analysis in Clinical and Life Science Research -- Pharmokinitic and Statistical Modelling -- Imputation Methods Approach to Clinical and Life Science Research Data Sets -- Ethical Perspective of Medical Research.
    Abstract: Recent Statistical techniques are one of the basal evidence for clinical research, a pivotal in handling new clinical research and in evaluating and applying prior research. This book explores various choices of statistical tools and mechanisms, analyses of the associations among different clinical attributes. It uses advanced statistical methods to describe real clinical data sets, when the clinical processes being examined are still in the process. This book also discusses distinct methods for building predictive and probability distribution models in clinical situations and ways to assess the stability of these models and other quantitative conclusions drawn by realistic experimental data sets. Design of experiments and recent posthoc tests have been used in comparing treatment effects and precision of the experimentation. This book also facilitates clinicians towards understanding statistics and enabling them to follow and evaluate the real empirical studies (formulation of randomized control trial) that pledge insight evidence base for clinical practices. This book will be a useful resource for clinicians, postgraduates scholars in medicines, clinical research beginners and academicians to nurture high-level statistical tools with extensive scope.
    Type of Medium: Online Resource
    Pages: XXXV, 356 p. 190 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811582103
    DDC: 610.72
    Language: English
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  • 52
    Online Resource
    Online Resource
    Berlin, Heidelberg :Springer Berlin Heidelberg :
    Keywords: Botany. ; Microbiology. ; Biodiversity. ; Applied ecology. ; Plants Evolution. ; Plant ecology. ; Plant Science. ; Microbiology. ; Biodiversity. ; Applied Ecology. ; Plant Evolution. ; Plant Ecology.
    Description / Table of Contents: Introduction: Façades colonized by aerophytic microorganisms -- Façades as a functional part of a building -- The environment façade -- History of aerobiology, in respect of research on man-made surfaces -- Tools/Methods -- Experimental investigations and the assessment of primary growth of microorganisms on modern buiding structures -- Assessment of starter germ load of materials. Germ counts for specimens -- Culture based taxonomic analysis -- Taxonomy -- Pre-culture investigation -- Sample collection and preparation -- Establishment of pure cultures -- Background concentrations -- Air germ measurement -- Sedimentation -- Germ load of precipitation -- Ecophysiologic data -- Testing methods in respect of ths susceptibility of building products against colonisation by microorganisms -- Aerophytic organisms colonizing façades: their diversity and taxonomy with recognition of ecophysiological characteristics -- Regnum Eubacteria – non oxygen phosynthetic active groups -- Regnum Archaea -- Division Rhodophyta – Class Rhodophyceae -- Division Stramenopiles (Heterokonta), Class Bacillariophyceae -- Division Stramenopiles (Heterokonta), Class Xanthophyceae -- Division Stramenopiles (Heterokonta), Class Eustigmatophyceae -- Division (Infraregnum) Chlorophyta, Class Chlorophyceae -- Division (Infraregnum) Streptophyta -- Class Bryopsida – Musci -- Class Pteridopsida -- Subregnum Eumycota -- Division Archemycota -- Class Zygomycetes -- Division Ascomycota -- Class Ascomycetes -- Division Basidiomycota -- Class Basidiomycetes -- Form of organisation Lichenes -- Formgroup Ascolichenes -- Synopsis -- Summary -- Acknowledgements -- Glossary 1 -- Glossary 2 (important technical terms) -- Literature.
    Abstract: This book provides a detailed overview of the microorganisms that form the initial growth on the exterior façades of buildings. It deals with the ecophysiological properties that characterize the basic conditions under which these microorganisms can occur on façades. In addition to an identification key for the types and forms of microorganisms, this book provides a detailed description of the individual organisms, stating their ecological range. Furthermore, the various ecological parameters are discussed in short chapters. Measures to prevent and combat the colonization of façades with microorganisms are also addressed. Specialists (architects, construction experts), builders, scientists and master students can find all the information they need on facade algae and fungi here. The authors Dr. Wolfgang Karl Hofbauer is chief scientist (taxonomy, ecophysiology and genetics) of the department Environment, Sensors and Hygiene at the Fraunhofer Institute for Building Physics. His professional research areas are taxonomy and ecophysiology of organisms on building surfaces, about which he did his doctorate in 2008, genetic barcoding of building relevant (micro)organisms and greening of building surfaces. Retired Prof. Dr. Dr.h.c Georg Gärtner worked and researched at the University of Innsbruck on the cultivation and taxonomy of soil-and airborne. algae for many years. In 2012, Prof. Gärtner was awarded an honorary doctorate by Sofia University for his services to the cooperation in algal studies between the botanical institutes of the University of Innsbruck and the University of Sofia.
    Type of Medium: Online Resource
    Pages: XI, 323 p. 185 illus., 110 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783662548332
    DDC: 580
    Language: English
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  • 53
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Botany. ; Plants Evolution. ; Plants Development. ; Plant Science. ; Plant Evolution. ; Plant Development.
    Description / Table of Contents: Chapter 1. The two contrary theories about organogenesis in morphology of the higher plants.-chapter 2. Saunders’ Leaf-skin Theory of Stem -- Chapter 3. Leaves are split axes -- Chapter 4. Re-evaluation of the evidences for the Telome Theory -- Chapter 5. What do hooded-awn barley, bitter bamboo, tortoise shell bamboo, paspalum and crabgrass show us? -- Chapter 6. The ontogenesis of higher plants -- Chapter 7. The organogenesis of higher plants -- Chapter 8. Conclusion.
    Abstract: This book written by Professor Chi Yen of Sichuan Agricultural University in Chinese was published by China Agriculture Press (ISBN 978-7-109-22791-0). It describes a new theory on the constitution of organs of the higher plants based on experimental evidence, the multiple secondary axis theory. This theory states that all organs of the higher plants are the constitution of multiple secondary axes. The primary axis extends bipolarly to initiate the above- and the below-ground parts of a plant, from which secondary axes develop. Leaves are split, expanded upper ends of terminal secondary axes. Stems are merged lower ends of the secondary axes, Vascular bundles are secondary structures developed within the axes which interconnect with each other to form the central core of the stem and branches and the veins in the leaves. Roots form through the downward extension of the lower ends of the axes toward or within the underground and branch roots are unsplit secondary axes. All new axes emerge from the inner side of existing, split axes. All floral organs including fruits, seeds and vegetative reproduction organs such as bulbils and plantlets, are deformed axes. This theory is significant in guiding the scientific design of the ideotype of crops to optimize the development of the economically important organ(s) of a crop.
    Type of Medium: Online Resource
    Pages: XII, 160 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811916854
    DDC: 580
    Language: English
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  • 54
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Cancer. ; Tumors Immunological aspects. ; Biomedical Research. ; Cancer Biology. ; Cancer Microenvironment. ; Tumour Immunology.
    Description / Table of Contents: Chapter 1: Interactions in cancer ecosystem -- Chapter 2: Local niche construction -- Chapter 3: Pre-metastatic niche -- Chapter 4: Emerging concepts in cluster metastasis -- Chapter 5: Neuronal regulation in cancer ecosystem -- Chapter 6: Endocrinal regulation in cancer ecosystem -- Chapter 7: Innate immune system in cancer ecosystem -- Chapter 8: Adaptive immune system in cancer ecosystem -- Chapter 9: Inflammation in cancer ecosystem -- Chapter 10: Metabolic regulation in cancer ecosystem -- Chapter 11: Vascular regulation in cancer ecosystem -- Chapter 12: Microbial interaction in cancer ecosystem -- Chapter 13: Viral interaction in cancer ecosystem -- Chapter 14: Evolution of cancer ecosystem -- Chapter 15: Driving force of cancer ecosystem -- Chapter 16: Modeling, visualizing and subtyping the cancer ecosystem -- Chapter 17: Bio-engineering methods to mimic cancer ecosystem -- Chapter 18: Cancer ecosystem-directed therapeutic strategies.
    Abstract: This book intends to report new concept of onco-spheres in cancer ecosystem. Onco-spheres are defined as where cancer cells (living organisms) dynamically interact with nontumor cellular (other living organisms) and noncellular components (non-living environmental factors) in the ‘host’ internal environment (habitat) to construct a self-sustainable cancer ecosystem, which can be scoped at three different levels: primary/regional, distal and systemic onco-spheres. Cancer cells should be conceived as ‘living organisms’, interacting with cellular or noncellular components in the host internal environment, not only with the local tumor microenvironment (TME) but also constantly communicating with a distant organ niche as well interacting with the host’s nervous, endocrine and immune systems, to construct a self-sustainable ‘biosphere’, as we termed the tumor ecosystem. By looking at the interaction of cancer and host as a unique ecosystem, we will use ecology principles to further delineate the features of the dynamics of the tumor ecosystem. As the pioneer in proposing this concept, we feel that this full-scale overview of the tumor ecosystem is able to inform the readers about this concept, and to pave the way for designing novel therapeutic strategies on actionable targets within tumor ecosystem. The book is likely to be of interest to immunologist, biologist, medical students, researchers and general public who wish to learn more on this new concept of tumor ecosystem, and how this could be applied in many fields of research.
    Type of Medium: Online Resource
    Pages: XIX, 701 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819911837
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Microtechnology. ; Microelectromechanical systems. ; Pharmaceutical chemistry. ; Biotechnology. ; Medical sciences. ; Biomedical Research. ; Microsystems and MEMS. ; Pharmaceutics. ; Biotechnology. ; Health Sciences.
    Description / Table of Contents: Part A: Applications of Nano Biotechnology in the development of Nano Medicine -- Chapter 1. Nanobiotechnology and its application in Nanomedicine: An Overview -- Chapter 2. Nanobiotechnology for therapeutic targeting of circulating tumor cells in the blood -- Chapter 3. Application of Nanobiotechnology in clinical diagnosis -- Chapter 4. Anti-diabetic Nano formulation from herbal source -- Chapter 5. Nanomaterials for alternative antibiotic therapy -- Part B: Nano Medicine: concept, development, clinical applications and evidences -- Chapter 6. Nano medicines and Nano drug delivery systems: trends and perspectives -- Chapter 7. Nano medicines in drug delivery from synthetic/natural sources to their clinical applications -- Chapter 8. Transdermal Nanomedicines for Reduction of Dose And Site-Specific Drug Delivery -- Chapter 9. Multifunctional mesoporous silica nanoparticles for biomedical applications -- Chapter 10. Advances in pulmonary Nano medicine for therapeutic management of respiratory diseases -- Chapter 11. Nanoemulsion Delivery of Herbal Products: Prospects and Challenges -- Chapter 12. Stimuli-responsive polymers for cancer Nano medicines -- Chapter 13. Carbohydrate-Derived Tailorable Interfaces: Recent Advances and Applications -- Chapter 14. Multifunctional Nano scale particles for theranostic application in healthcare -- Chapter 15. Ligand nanoparticle conjugation approach for targeted cancer chemotherapy -- Chapter 16. Tunable Biopolymeric Drug Carrier Nanovehicles and Their Safety -- Chapter 17. Nano medicine for challenging solid tumors: Recent trends and future ahead -- Part C: Regulatory, safety and marketing aspects of Nano Medicine -- Chapter 18. Recent trends for Nano medicine safety -- Chapter 19. Nano toxicity and risk assessment of Nano medicines -- Chapter 20. Clinical toxicity of Nano medicines -- Chapter 21. Nano Medicine: Risk, Regulation, Safety and Public Health -- Chapter 22. New deliveries and nanomedicines: Commercial aspects and business perspectives -- Chapter 23. Global growth of Nano medicines and what role it will play for economically weak countries.
    Abstract: This book reviews the application of Nanobiotechnology in the development of Nanomedicine, while also discussing the latest trends and challenges in the clinical translation of Nanomedicine. Nanomedicine refers to the application of Nanotechnology to medicine and holds tremendous potential for achieving improved efficiency, bioavailability, dose response, personalized medicine and enhanced safety as compared to conventional medicines. The book first introduces readers to the basic concepts of Nanomedicine, and to technological advances in and applications of Nanotechnology in treatment, diagnosis, monitoring, and drug delivery. In turn, it reviews the current status of multi-functionalization strategies for using Nanoparticles in the targeted delivery of therapeutic agents. The book’s third and final section focuses on the regulatory and safety challenges posed by Nanomedicine, including industry and regulatory agencies’ efforts to address them.
    Type of Medium: Online Resource
    Pages: XVI, 635 p. 57 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811562556
    DDC: 610.72
    Language: English
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  • 56
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Human physiology. ; Life sciences. ; Pharmacology. ; Biomedical Research. ; Human Physiology. ; Life Sciences. ; Pharmacology.
    Description / Table of Contents: Chapter 1: HDL Structure -- Chapter 2: HDL and Cholesterol ester transfer protein (CETP) -- Chapter 3: HDL and Endothelial Function -- Chapter 4: HDL and lipid metabolism -- Chapter 5: HDL and oxidation -- Chapter 6: Scavenger Receptor Class B Type I and HDL -- Chapter 7: ABCA1, ABCG1 and cholesterol homeostasis -- Chapter 8: HDL and ASCVD -- Chapter 9: HDL and Diabetes -- Chapter 10: HDL and sepsis -- Chapter 11: HDL mimetic peptides -- Chapter 12: HDL and microRNAs -- Chapter 13: HDL-kidney diseases -- Chapter 14: HDL and therapy -- Chapter 15: High-density lipoprotein and Surgery.
    Abstract: This book focuses on both high-density lipoproteins (HDL) metabolism and related diseases from the perspectives of the world-class experts in HDL. Several chapters in this book provide the overall information about HDL metabolism via detailed discussion of HDL structures as well as several key molecules involved in its functions, such as SR-B1 and Cholesteryl Ester Transfer Protein Inhibitors and so on. The rest of this book illustrates the connection between HDL and several diseases that are the major concerns of people’s health in many countries, and devotes to exploring the therapies of HDL related diseases. With a better understanding of the HDL metabolism and diseases, this book will benefit the audiences with interest in HDL from biomedicine to clinical practice.
    Type of Medium: Online Resource
    Pages: X, 195 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811915925
    Series Statement: Advances in Experimental Medicine and Biology, 1377
    DDC: 610.72
    Language: English
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  • 57
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Medical jurisprudence. ; Biomaterials. ; Nucleic acids. ; Biomedical Research. ; Forensic Medicine. ; Nucleic Acid.
    Description / Table of Contents: 1 Initial response at crime scenes and prioritization of efforts -- 2 Crime scene processing: documentation and evaluation -- 3 Crime Scene Searching: An Exploration of Forensic Evidence -- 4 Collection, Preservation and Packaging: Forensic Evidence Management -- 5 Paint, Soil and Glass Evidences: A Silent Witnesses -- 6 Questioned Document Examination: A Prevalent Dispute -- 7 Medicolegal Examination: A Guide to the Criminal Investigation System -- 8 Examination of Tampered Voice. .
    Abstract: This book provides deep insight into the significance of various forensic techniques underlying the methodical approaches in criminal investigations. The book comprises numerous case studies, examples, and reference materials. It emphasizes on the better practices for criminal investigations including contemporary examinations. The book also describes various methods for investigation of crime scene and evidence collection including biological evidences to the resources of law enforcement agencies. This book encompasses the procedure for crime scene-documentation through photography, video, and diagrams and highlights the best practices of packaging the biological evidences at a crime scene. Further, it summarizes the role of forensic autopsy to the criminal investigation system. As such, the book is helpful for forensic scientists, medical practitioners, educators and law enforcement personnel.
    Type of Medium: Online Resource
    Pages: V, 239 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811640919
    DDC: 610.72
    Language: English
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  • 58
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Bioinformatics. ; Data mining. ; Application software. ; Biomedical Research. ; Bioinformatics. ; Data Mining and Knowledge Discovery. ; Computer and Information Systems Applications.
    Description / Table of Contents: Chapter 1. Integrative Bioinformatics: History and Perspective -- Chapter 2. From Genotypes to Phenotypes - A Plant Perspective on Current Developments in Data Management and Data Publication -- Chapter 3. Research data resources for epidemiology -- Chapter 4. Data Warehousing of Life Science Data -- Chapter 5. Automation in Graph-Based Data Integration and Mapping -- Chapter 6. DaTo: an Integrative Web Portal for Biological Databases and Tools -- Chapter 7. The Use of Data Integration and Knowledge Graphs in Modern Molecular Plant Breeding -- Chapter 8. Integrative data analysis and exploratory data mining in biological knowledge graphs -- Chapter 9. Exploring plant transcription factor regulatory networks -- Chapter 10. Microbiome and big-data mining -- Chapter 11. Data Integration Applications in Medical Information Systems -- Chapter 12. Visualising Metabolic Pathways and Networks: Past,Present,Future -- Chapter 13. Comprehensive open-source Petri net toolchain for modeling and simulation in systems biology -- Chapter 14. Immersive Exploration of Cell Localization Scenarios using VR, Spatialized Video Communication and Integrative Bioinformatics -- Chapter 15. IoS: a Needed Platform for Scientific Workflow Management -- Chapter 16. Revealing genotype-phenotype interactions: The AgroLD experience and challenges -- Chapter 17. Interactive Data Analyses Using Tbtools -- Chapter 18. Analyzing multi-omic data with integrative platforms.
    Abstract: This book provides an overview of the history of integrative bioinformatics and the actual situation and the relevant tools. Subjects cover the essential topics, basic introductions, and latest developments; biological data integration and manipulation; modeling and simulation of networks; as well as a number of applications of integrative bioinformatics. It aims to provide basic introduction of biological information systems and guidance for the computational analysis of systems biology. This book covers a range of issues and methods that unveil a multitude of omics data integration and relevance that integrative bioinformatics has today. It contains a unique compilation of invited and selected articles from the Journal of Integrative Bioinformatics (JIB) and annual meetings of the International Symposium on Integrative Bioinformatics.
    Type of Medium: Online Resource
    Pages: XI, 386 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811667954
    DDC: 610.72
    Language: English
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  • 59
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Radiology. ; Spectrum analysis. ; Pharmaceutical chemistry. ; Nutrition   . ; Biomedical Research. ; Radiology. ; Spectroscopy. ; Pharmaceutics. ; Nutrition.
    Description / Table of Contents: Ch 1: Electron Spin Resonance- An Introdcution -- Ch 2: ESR – Applications in Healthcare and Pharmaceutical Science -- Ch 3: ESR Applications in Paleontology and Geochronology -- Ch 4: ESR Applications in Food Science.
    Abstract: This book introduces the audience with basic theoretical and experimental aspects of Electron Spin Resonance (ESR) Spectroscopy. It further talks about ESR spectroscopy applications in Healthcare & Pharmaceutical Science, Paleontology & Geochronology and Food Science. Mathematical details have been kept to a necessary minimum and emphasis is given to highlight the applications of the technique.
    Type of Medium: Online Resource
    Pages: X, 72 p. 32 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030641986
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    DDC: 610.72
    Language: English
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  • 60
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical policy. ; Quality of life. ; Biomedical Research. ; Health Policy. ; Quality of Life Research.
    Description / Table of Contents: Foreword: Challenges & Opportunities for LGBT Populations and Cancer in Global Oncology -- Introduction -- Africa -- A Double Dose Of Stigma – Being Gay And Living With Cancer In Kenya -- Sexual Orientation, Gender Identity and Cancer in South Africa -- Americas -- Making the Situation of TLGBI People around Cancer visible: Observations from the Andean Region -- Cancer Care Challenges for the LGBT Population in Brazil -- Cancer and the SGM Population in Canada and the United States of America -- South-East Asia -- The South-East Asia Region: Societal Conditions for LGBT Health and Cancer Research -- Europe -- Foreword: The Eurocentralasian Lesbian* Community Perspective on Cancer and LBQ women: Advocating for more Research and Activism Collaboration -- LGBT+ and Cancer in the WHO European Region: Current Situation in 12 Eastern European and Central Asian Countries -- Sexual and Gender Minorities and Cancer in Germany: The Striking Absence of Understanding their Cancer-related Needs -- LGBT Populations and Cancer in the UK -- Eastern Mediterranean -- LGBT Populations and Cancer in the Eastern Mediterranean Region: Insights and Challenges with a Focus on Lebanon -- Western Pacific -- LGBT Populations and Cancer in Australia and New Zealand -- Challenges in Cancer Control Confronting the LGBT Population in China: Health Risks, Unique Barriers, and Unmet Needs -- What Have We Learned about Cancer and the Global LGBT Community? -- Index.
    Abstract: Lesbian, Gay, Bisexual, and Transgender (LGBT) also known as sexual and gender minority (SGM) populations have been the focus of global attention. Most importantly, LGBT populations have been addressed in the context of human rights in multiple reports and other activities by the United Nations and other international organizations. There is great variation among countries in the recognition of LGBT individuals’ human rights. A global focus on LGBT populations’ health is still limited, with the notable exception of HIV research. This book on LGBT populations and cancer in the global context is, therefore, an important step in that it will broaden the focus on LGBT populations’ health. Globally, cancer is the second leading cause of death. Cancer morbidity and mortality are increasing disproportionately among populations in lower-income countries. A review conducted by the World Health Organization (WHO) found that of the 82% of member states (158) countries, only 35% of the national cancer control plans addresses vulnerable population, including LGBT populations. These findings reflect an increasing awareness about equity when addressing cancer prevention and control, including LGBT populations. This book addresses LGBT populations’ cancer burden across countries that range from high- to low-income countries to support efforts in diverse countries that are working towards reducing LGBT populations’ cancer burden. It documents place-specific challenges that impede progress towards reducing the LGBT cancer burden as well as critically assesses the variation in cancer control efforts that target LGBT populations and cancer to support progress at a global scale. This book includes six sections that cover the six WHO regions, with each chapter written by an author from the specific region s/he is covering. Each chapter makes use of a template that contextualizes the region, local data collection/availability, risk factors, cancer prevention, detection, diagnosis, treatment, and survivorship.
    Type of Medium: Online Resource
    Pages: X, 335 p. 3 illus., 2 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031065859
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Medical genetics. ; Cancer. ; Lipids. ; Biomedical Research. ; Pharmacology. ; Medical Genetics. ; Cancer Biology. ; Lipidology.
    Description / Table of Contents: Preface -- Introduction of Druggable Lipid Signaling Pathway -- Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Development -- Druggable Prostanoid Pathway -- Targeting Leukotrienes as a Therapeutic Strategy to Prevent Comorbidities Associated with Metabolic Stress -- Epoxy Fatty Acids are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation -- Druggable Sphingolipid Pathway -- Druggable Lysophospholipid Pathway -- Druggable targets in endocannabinoid signaling -- Drugging the phosphoinositide 3-kinase (PI3K) and phosphatidylinositol 4-kinase (PI4K) family of enzymes for treatment of cancer, immune disorders, and viral/parasitic infections -- Druggable Lipid GPCRs: Past, Present, and Prospects. .
    Abstract: This edited work presents a series of reviews focusing on Druggable Lipid Signaling Pathways. It enables researchers in both academic institutions and industry as well as physicians to understand historical aspects of lipid signaling and future directions of drug discovery targeting lipid signaling pathways. This book provides 9 pathways including acyltransferases, prostanoids, leukotrienes, epoxy fatty acids, sphingolipids, lysophospholipids, endocannabinoids, phosphoinositides, and lipid GPCRs. Readers will discover the importance of each lipid signaling pathway that contributes to broad range of diseases including neurological and neuropsychiatric diseases, pain, metabolic syndromes, cardiovascular diseases, cancer, dermatological diseases, fibrosis, inflammation, etc. Also, readers will recognize that many drugs targeting lipid signaling have been clinically used. Drugs currently under development are also discussed in each chapter, which includes some information about clinical trials and strategic drug designs. .
    Type of Medium: Online Resource
    Pages: VI, 260 p. 33 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030506216
    Series Statement: Advances in Experimental Medicine and Biology, 1274
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Internal medicine. ; Hematology. ; Biomedical Research. ; Cell Biology. ; Internal Medicine. ; Hematology.
    Description / Table of Contents: Live Donors of Tissue -- Deceased Tissue Donors -- Banking and Use of Umbilical Cord Blood -- Ocular tissue banking -- Banking of Heart Valves -- Cryopreservation and Banking of Haematopoietic Progenitor Cells -- Storage, Processing and Preservation -- Cryopreservation in tissue banking -- Sterilisation by Irradiation -- Screening the tissue donor for infectious agents -- Contamination in the Tissue Way -- Establishing a Quality System in a Tissue Establishment -- IT System requirements for Tissue and Cell Banking -- Ethical and Regulatory Aspects of Cell and Tissue Banking -- Human embryonic stem cell banking for clinical applications – 20 years from their isolation.
    Abstract: It has been 10 years since the first edition of ‘Essentials of Tissue Banking’ has been published. There is still relatively little published on the technical and scientific principles on routine tissue and cell banking based on scientific principles. The 1st edition was very successful and, after a 10 year gap, there is a need of an update and an expansion of the book’s remit. The format of the book follows that of the previous edition- split into 5 sections. Management of donors and the banking of common tissues and cells; Principles of storage and processing of tissues and cells; Ensuring the safety of the products by testing the donor, the tissues and the environment, supported by a quality system and an IT infrastructure- all working within the constraints of current regulatory and ethical environments. This edition however provides a significant update. Many the chapters have been completely rewritten by different experts. Like the 1st edition, they were given a free hand in the way they wrote their chapter, with a guideline that they had to be concise, clear and up to date. The authors were also asked to provide the scientific and technical basis that provides the rationale of the processes they describe. Also, the scope of the book has been somewhat extended. In view of the fact that many cellular therapies are now routinely practiced, 2 new chapters have been added: one on the banking of haematopoietic stem cells and one on human embryonic stem cells. They have been deliberately chosen to illustrate the extreme spectrum of cellular therapies from one of the simplest to one of the most complex. The intention of the book has remained the same: to cover and update banking of current practices in essential tissue and cell banking. It is therefore hoped that by keeping the book as concise and up to date as possible, it will find a place on the shelves of many tissue establishments.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 48 illus., 28 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030716219
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biochemistry. ; Genetics. ; Biomedical Research. ; Biochemistry. ; Genetics and Genomics.
    Description / Table of Contents: Central dogma of molecular biology -- Impact of chromatin structure -- Epigenetics enables gene expression -- Gene regulation in the context of nuclear architecture -- Core promoter -- TATA box and other core promoter elements -- Genome-wide core promoter identification -- TFIID and Mediator as paradigms of multi-protein complexes -- Site-specific transcription factors and their domains -- Classification of transcription factors -- Activation of transcription factors -- Programing cellular differentiation by transcription factors -- Inflammatory signaling via NF-KB -- Sensing cellular stress via p53 -- The nuclear receptor superfamily -- Molecular interactions of nuclear receptors -- Physiological role of nuclear receptors -- Next-generation sequencing -- Gene regulation in the context of Big Biology -- Exploring genome-wide transcription factor binding -- Integrating epigenome-wide datasets -- Cytosines and their methylation -- Histone modifications -- Gene regulation via chromatin modifiers -- Sensing energy metabolism via chromatin modifiers -- Epigenetics and chromatin -- Genome-wide understanding of epigenetics -- CTCF and genetic imprinting -- Epigenetics in health and disease -- Nucleosome positioning at promoters -- Chromatin remodeling -- Transcriptional dynamics in the presence of chromatin -- Organization of the nucleus -- Non-coding RNAs -- miRNAs and their regulatory potential -- Long ncRNAs -- Enhancer RNAs.
    Abstract: This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.
    Type of Medium: Online Resource
    Pages: XVI, 149 p. 71 illus., 70 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030523213
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Internal medicine. ; Biochemistry. ; Physiology. ; Biomedical Research. ; Cell Biology. ; Internal Medicine. ; Biochemistry. ; Physiology.
    Description / Table of Contents: Preface -- Part 1 Basics on coenzyme Q -- Introduction. The current coenzyme Q science and knowledge -- Molecular structure, biosynthesis, and distribution of coenzyme Q -- Coenzyme Q function in mitochondria -- Extramitochondrial coenzyme Q10 in aging -- Regulation of the synthesis of Coenzyme Q10 -- Part 2 Coenzyme Q in aging studies -- Coenzyme Q and aging in C. elegans -- Coenzyme Q and aging in the fruit fly Drosophila melanogaster -- The aging process and coenzyme Q: clk-1 mouse models -- Reduced coenzyme Q10 decelerates senescence and age-related hearing loss in senescence-accelerated mice by activating mitochondrial functions -- Part 3 Age-related diseases and coenzyme Q -- Coenzyme Q, mtDNA and mitochondrial dysfunction during aging -- Coenzyme Q10 and metabolic syndrome -- Coenzyme Q and age-related neurodegenerative disorders: Parkinson and Alzheimer diseases -- Immunosenescence and CoQ10 -- Coenzyme Q10 in fertility and reproduction -- Part 4 Prolongevity effectors and Coenzyme Q -- Calorie restriction, longevity and coenzyme Q -- Age dependent changes of coenzyme Q levels and its induction in experimental systems -- Effects of coenzyme Q10 supplementation on elderly people -- Index.
    Abstract: This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging. The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants. The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice. Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction. The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation. Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.
    Type of Medium: Online Resource
    Pages: XII, 369 p. 50 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030456429
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Reproductive health. ; Cytology. ; Biomedical Research. ; Reproductive Medicine. ; Cell Biology.
    Description / Table of Contents: Ch 1: The seminiferous epithelial cycle of spermatogenesis: Role of non-receptor protein kinases -- Ch 2: Sertoli cells: immunology and spermatogenesis -- Ch 3: Innate immunity and spermatogenesis -- Ch 4: Cell apoptosis and spermatogenesis -- Ch 5: Transcriptional regulation of spermatogenesis -- Ch 6: Sertoli cell cytoskeleton and spermatogenesis -- Ch 7: Leydig cell and spermatogenesis -- Ch 8: Cross-talk of cell junctions to support spermatogenesis -- Ch 9: Coordination of F-actin- and MT-based cytoskeletons to support spermatogenesis -- Ch 10: Regulation of the blood-testis barrier by basement membrane laminin-α2 chain -- Ch 11: Regulation of spermatogenesis by collagens -- Ch 12: Androgen regulation of spermatogenesis -- Ch 13: Use of molecular modeling to study spermatogenesis -- Ch 14: Acrosome biogenesis during spermatogenesis -- Ch 15: Stem cells and spermatogenesis -- Ch 16: Advances in our understanding of spermatogenesis in humans -- Ch 17: Leydig cell function in aging men -- Ch 18: Regulation of human spermatogenesis.
    Abstract: This new edition provides an update on the molecular mechanisms that regulate spermatogenesis. In addition to the rodent as a study model, chapters also include research on studies in humans. It includes the latest approaches of studying spermatogenesis, such as the use of bioinformatics, molecular modeling and others which are not commonly found in published materials. It also reviews the latest developments in the field, such as studies on the role of regulatory RNAs on spermatogenesis. Due to the declining fertility rate among men, a brand new chapter highlights the impact of environmental toxicants on spermatogenesis.
    Type of Medium: Online Resource
    Pages: X, 319 p. 44 illus., 40 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030777791
    Series Statement: Advances in Experimental Medicine and Biology, 1381
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Cardiovascular system. ; Physiology. ; Cardiology. ; Clinical biochemistry. ; Biomedical Research. ; Cardiovascular Physiology. ; Cardiology. ; Medical Biochemistry.
    Description / Table of Contents: Past, present and future perspectives of renin angiotensin system -- Biochemical pathways of renin angiotensin system -- Structure-function relationships of angiotensin II receptors -- Signal transduction mechanism of angiotensin II -- Renin angiotensin system: Pathophysiology and clinical implications in cardiovascular disease COVID-19 infection -- Angiotensin II and the pathogenesis of hypertension -- Signaling transduction of angiotensin II in hypertension -- Role of angiotensin II type 1 receptors in vascular remodeling in hypertension -- Molecular and cellular mechanisms of renin-angiotensin system in hypertension -- Tissue renin-angiotensin system and risks in hypertension -- Oxidative stress and angiotensin II-induced hypertension -- Angiotensin II: inflammatory system disorder and hypertension -- Therapeutic approaches for angiotensin receptor blockers in hypertension -- Renin-angiotensin systems: A pivotal role in the development of atherosclerosis -- Angiotensin II induced intracellular signaling pathways in pathogenesis of atherosclerosis -- Cellular and molecular mechanisms of Ang II: Contribution to atherosclerotic plaque vulnerability -- Role of angiotensin II, nitric oxide and reactive oxygen species in atherosclerosis -- The renin-angiotensin system and inflammatory processes in atherosclerotic lesion formation -- Role of renin-angiotensin system in alterations in blood lipids and gene expression in atherogenesis -- Effects of angiotensin-converting enzyme and receptors in atherosclerosis -- Effects of angiotensin II on cardiac arrhythmia and signal transduction -- Angiotensin II induced oxidative stress contribute to ventricular arrhythmias -- Modulation of renin angiotensin system: Beneficial effect on ventricular arrhythmias -- ACE inhibitor and ventricular arrhythmia in ischemic heart disease -- The renin-angiotensin system modulators and cardiac arrhythmias -- Angiotensin receptor blockers in the treatment of arrhythmias -- Angiotensin II induced cardiac hypertrophy and heart failure -- Renin-angiotensin system: Role in cardiac remodeling and subcellular defects in heart failure -- Renin-angiotensin system: Molecular and cellular mechanisms in heart failure -- Role of angiotensin II receptor mRNA expression in heart failure -- Renin angiotensin system: Mitochondrial dysfunction in the progression of heart failure -- Angiotensin II type 1 receptor: Genetic polymorphisms and heart failure -- Angiotensin converting enzyme 2 and angiotensin metabolism in heart failure -- Cellular and molecular mechanisms of renin-angiotensin system blockade in heart failure: An update -- Angiotensin II receptor antagonists: Modulation of the extracellular matrix regulatory system in heart failure.
    Abstract: This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.
    Type of Medium: Online Resource
    Pages: XVIII, 452 p. 71 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031149528
    Series Statement: Advances in Biochemistry in Health and Disease, 24
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Geriatrics. ; Ophthalmology. ; Pathology. ; Cytology. ; Pharmacy. ; Biomedical Research. ; Geriatrics. ; Ophthalmology. ; Pathology. ; Cell Biology. ; Pharmacy.
    Description / Table of Contents: Chapter 1. Literature review -- Chapter 2. Results of experimental studies of short peptides (cytogens) in ophthalmology -- Chapter 3. Results of the clinical study of short peptides (cytogens) in ophthalmology -- Conclusion.
    Abstract: This book discusses the pathology of the retina, and reviews current research on the use of cell replacement therapy and short peptides to restore functional activity in retinal neurons. As the book describes, pathologies of the retina, including age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, present a long-standing challenge in the practice of clinical ophthalmology. Modern treatment for these conditions, which lead to irreversible blindness, includes laser exposure, surgical intervention, and drugs. These treatments aim to reduce the risk of new complications in the eye; pathogenetic therapy of degenerative diseases of the retina is practically absent in current ophthalmic practice. The first section of the book reviews the molecular mechanisms of age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, and reports on methods of treatment. The second section presents the results of recent experimental studies of the effects of short peptides on pluripotent embryonic cells; on proliferative activity in retinal cells and pigment epithelium; on expression of markers of differentiation or retinal neurons and pigment epithelium; and on the course of hereditary retinal pigmentation in Campbell rats. The third section offers results of clinical studies on the effectiveness of short peptides in patients with macular degeneration, and in patients with retinitis pigmentosa. The author concludes that the regular use of peptides in the treatment of degenerative diseases of the retina can slow the progression of the pathological process and preserve the patient’s vision for some 10-15 years. In addition, in 80 percent of patients, it is possible to increase visual function by increasing visual acuity, improving the boundaries of the visual field and the fundus.
    Type of Medium: Online Resource
    Pages: VI, 90 p. 17 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030501600
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medicine Philosophy. ; Medical sciences. ; Science Philosophy. ; Biomedical Research. ; Philosophy of Medicine. ; Health Sciences. ; Philosophy of Science.
    Abstract: This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final part looks at more clinical or practical perspectives. It thereby gathers, across 30 chapters, diverse perspectives from the broad fields of evolutionary and systems biology, immunology, and biogerontology, more specific areas such as odontology, cardiology, neurology, and public health, as well as philosophical reflections on mental health, sexuality, authenticity and medical theories. The overarching aim is to inform, inspire and encourage intellectuals from various disciplines to assess whether explanations in these disparate fields and across biological levels can be sufficiently systematized and unified to clarify the complexity of health. It will be particularly useful for medical graduates, philosophy graduates and research professionals in the life sciences and general medicine, as well as for upper-level graduate philosophy of science students.
    Type of Medium: Online Resource
    Pages: XVII, 555 p. 30 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030526634
    Series Statement: Healthy Ageing and Longevity, 12
    DDC: 610.72
    Language: English
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    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Metabolism Disorders. ; Genetics. ; Cardiovascular system. ; Physiology. ; Biomedical Research. ; Metabolic Disease. ; Genetics and Genomics. ; Cardiovascular Physiology.
    Description / Table of Contents: An overview of genome editing in cardiovascular and metabolic diseases -- Bioinformatics research methodology of genome editing in cardiovascular and metabolic diseases -- Online databases of genome editing in cardiovascular and metabolic diseases -- Application of systems biology for genome editing involved in regulating of cardiovascular and metabolic diseases -- Bioinformatics for reducing off-targets in cardiovascular and metabolic diseases -- Genome editing and cardiac regeneration -- Genome editing and myocardial development -- Genome editing and heart failure -- Genome editing and pathological cardiac hypertrophy -- Genome editing and cardiac remodeling -- Genome editing and diabetic cardiomyopathy -- Genome editing and cardiac arrhythmias -- Genome editing and atrial fibrillation -- Genome editing and muscle atrophy -- Genome editing and obesity -- Genome editing and fatty liver -- Genome editing and diabetes -- Genome editing and gout -- Genome editing and protein energy malnutrition -- Genome therapy and cardiovascular diseases -- Therapeutics in metabolic diseases -- Gene editing and human iPSCs in cardiovascular and editing diseases -- Prospective advances in genome editing investigation.
    Abstract: This book provides the latest research progress on genome editing in cardiovascular and metabolic diseases and includes bioinformatics research methodology of genome editing. Genome editing is a genetic engineering technique precisely modified specific target genes of organism genome, which has been applied to basic theoretical research and production applications from plants and animals to gene therapy of human beings. Cardiovascular and metabolic diseases have become major factors affecting human health worldwide. This book contains information about bioinformatics, genome editing in cardiovascular diseases, genome editing in metabolic diseases and therapeutic effects. It will be useful for biologist, cardiologist, cardiovascular surgeons, endocrinologist, internists, nurses, undergraduate and graduate students in medicine and cell biology and others interested in cardiovascular and metabolic medicine.
    Type of Medium: Online Resource
    Pages: XII, 339 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811956423
    Series Statement: Advances in Experimental Medicine and Biology, 1396
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Biochemistry. ; Psychology. ; Dentistry. ; Endocrinology. ; Biomedical Research. ; Medical Biochemistry. ; Biochemistry. ; Behavioral Sciences and Psychology. ; Dentistry. ; Endocrinology.
    Description / Table of Contents: Part 1: What is Salivary Bioscience, Why is it Important, and How Do We Study It? -- Chapter 1: Foundations of Interdisciplinary Salivary Bioscience: An Introduction (Granger et al.) -- Chapter 2: Salivary Gland Anatomy and Physiology (Hernández et al.) -- Chapter 3: Saliva Collection, Handing, Transport, and Storage: Special Considerations and Best Practices for Interdisciplinary Salivary Bioscience(Padilla et al.) -- Chapter 4: Analytical Strategies and Tactics in Salivary Bioscience (Riis et al.) -- Part 2: Physiology and Development Research and Applications (Part 2 Editor: Dr. Jenna Riis) -- Chapter 5: Salivary Bioscience, Human Stress, and the Hypothalamic Pituitary Adrenal Axis (Clow et al.) -- Chapter 6: The Use of Saliva for Genetics and Epigenetics Research (Nemoda et al.) -- Chapter 7: Saliva as a Window Into the Human Oral Microbiome and Metabolome(Whiteson et al.) -- Chapter 8: Salivaomics, saliva Exo-somics, and Saliva Liquid Biopsy (Wong et al.) -- Chapter 9: Salivary Bioscience, Immunity, and Inflammation (Riis et al.) -- Chapter 10:Salivary Bioscience and Human Development (Hibel et al.) -- Part 3: Biomedical Research and Related Applications (Part 3 Editor: Dr. Elizabeth Thomas) -- Chapter 11: Biomedical Research and Related Applications:Current Assay Methods and Quality Requirements in Oral Fluid Diagnostics Applications (Granger S. et al.) -- Chapter 12: Salivary Biomarkers and Neurodegenerative Conditions (Thomas et al.) -- Chapter 13: The Use of Antibodies in Saliva to Measure PathogenExposure and Infection(Heaney et al.) -- Chapter 14: Salivary Bioscience and Pain (Payne et al.) -- Chapter 15: Salivary Bioscience and Environmental Exposure Assessment (Panuwet et al.) -- Chapter 16: Saliva and Drugs of Abuse (Navazesh et al.) -- Chapter 17: Therapeutic Drug Monitoring in Saliva (Thomas) -- Chapter 18: Salivary Bioscience and Periodontal Medicine (Freire et al.) -- Chapter 19: Salivary Bioscience and Cancer (Navazesh et al.) -- Part 4: Psychosocial Research and Applications(Part 4 Editor: Dr. Kate Ryan Kuhlman) -- Chapter 20: Salivary Bioscience in Clinical Psychologyand Psychiatry(Kuhlman) -- Chapter 21: Salivary Bioscience Research in Health Psychology and Behavioral Medicine (Hoyt et al.) -- chapter 22: The Neuroscience of Human Social Behavior: A Review of How Testosterone and Cortisol Underpin Competition and Affiliation Dynamics (Kornienko et al.) -- chapter 23: Salivary Studies of the Social Neuroscience of Human-animal Interaction (Pendry et al.) -- Part 5: Population Health Research and Applications(Part 5 Editor: Dr. Marcus Taylor) -- Chapter 24: Salivary Bioscience and Military, Space, and OperationalResearch(Roma et al.) -- Chapter 25: Salivary Bioscience Research Related to Prenatal Adversity (Eiden et al.) -- Chapter 26: Salivary Bioscience and Pediatrics (Johnson et al.) -- Chapter 27: Use of saliva to better understand the experience of adulthood and aging(Almeida et al.) -- Chapter 28: Salivary Bioscience and Research on Animal Welfare and Conservation Science(Staley et al.) -- Part 6: The Way Forward: Future Directions for the Science and Practice of Salivary Bioscience -- Chapter 29:Applications of Salivary Bioscience to Precision Medicine (Kuhlman) -- Chapter 30:Public Health and IndustryApplications of Salivary Bioscience (Riis et al.) -- Chapter 31: Envisioning the Future of Interdisciplinary Salivary Bioscience (Granger et al.).
    Abstract: This book provides the first comprehensive overview of the emerging field of interdisciplinary salivary bioscience. It serves as a foundational reference guide to the collection, analysis, and interpretation of salivary data, as well as its myriad applications in medicine, surveillance and public health. The ease and non-invasive nature of saliva collection makes it highly useful in diverse fields such as pediatrics, dentistry, neuroscience, psychology, animal welfare and precision medicine. This book introduces students and scientists alike to the vast potential of salivary bioscience in both research and practice.
    Type of Medium: Online Resource
    Pages: XIV, 751 p. 56 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030357849
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical microbiology. ; Parasitology. ; Biomedical Research. ; Medical Microbiology. ; Parasitology.
    Description / Table of Contents: Preface -- Chapter1. Advances in experimental research about periodontitis: lessons from the past, ideas for the future (Julien Santi-Rocca) -- Part I: Periodontal microbiota -- Chapter 2. Microbiota in Periodontitis: advances in the omic era (Shao Bing Fong, Emile Boyer, Martine Bonnaure-Mallet, Vincent Meuric) -- Chapter 3. Aggregatibacter actinomycetemcomitans: from basic to advanced research (Abdelhadi Hbibi, Amal Bouziane, Badiaa Lyoussi, Mimoun Zouhdi, Driss Benazza) -- Chapter 4. Meta-analyses on the Periodontal Archaeome (Jéssica Alves de Cena, Yuri Silvestre-Barbosa, Aline Belmok, Cristine Miron Stefani, Cynthia Maria Kyaw, Nailê Damé-Teixeira) -- Chapter 5. Parasites in periodontal health and disease: a systematic review and meta-analysis (David Felipe Martin-Garcia, Malik Sallam, Gabriela Garcia, Julien Santi-Rocca) -- Chapter 6. Fungi - a component of the oral microbiome involved in periodontal diseases (Justyna Karkowska-Kuleta, Dorota Satala, Magdalena Smolarz, Marcin Zawrotniak, Maria Rapala-Kozik) -- Chapter 7. Herpesviruses in periodontitis: An umbrella review (Aleksandar Jakovljevic, Miroslav Andric, Jelena Jacimovic, Jelena Milasin, Javier Enrique Botero) -- Part II: Periodontitis pathophysiology -- Chapter 8. Recent updates on microbial biofilms in periodontitis: an analysis of in vitro biofilm models (Maick Meneguzzo Prado, Nathalia Figueiredo, Andréa Pimenta, Tamires Szeremeske Miranda, Magda Feres, Luciene Cristina Figueiredo, Josiane de Almeida, Bruno Bueno-Silva) -- Chapter 9. Update on B cell response in periodontitis (Julien Demoersman, Jacques Olivier Pers) -- Chapter 10. Polarization profiles of T lymphocytes and macrophages responses in periodontitis (Franco Cavalla, Marcela Hernández) -- Chapter 11. Complementary experimental methods in genetics open up new avenues of research to elucidate the pathogenesis of periodontitis (Arne S. Schaefer) -- Part III: Periodontitis-associated conditions -- Chapter 12. Update on the bidirectional link between diabetes and periodontitis (Leila Salhi, Michèle Reners) -- Chapter 13. Periodontitis as a risk factor for Alzheimer’s disease: the experimental journey so far, with hope of therapy (Alice Harding, Shalini Kanagasingam, Richard Welbury, Sim K. Singhrao) -- Chapter 14. Cardiovascular diseases and periodontitis (Peter Riis Hansen, Palle Holmstrup) -- Part IV: Therapeutic management of periodontitis -- Chapter 15. Update on the role of cytokines as oral biomarkers in the diagnosis of periodontitis (Triana Blanco-Pintos, Alba Regueira-Iglesias, Carlos Balsa-Castro, Inmaculada Tomás) -- Chapter 16. Non-surgical periodontal treatment: SRP and innovative therapeutic approaches (Alexia Vinel, Antoine Al Halabi, Sébastien Roumi, Hélène Le Neindre, Pierre Millavet, Marion Simon, Constance Cuny, Jean-Sébastien Barthet, Pierre Barthet, Sara Laurencin-Dalicieux) -- Chapter 17. Update on the roles of oral hygiene and plaque control on periodontal disease (Leila Salhi, Bruno De Carvalho, Michèle Reners) -- Chapter 18. Multi-photonic adjunctive therapy for the management of periodontitis: recent advances and new treatment approach (Marco Giannelli, Daniele Bani) -- Chapter 19. Probiotics during the therapeutic management of periodontitis (Flavia Furlaneto, Karin Hitomi Ishikawa, Michel Reis Messora, Marcia P A Mayer) -- Chapter 20. Periodontal cell therapy: a systematic review and meta-analysis (Antoine Dubuc, Valérie Planat-Bénard, Mathieu Marty, Paul Monsarrat, Philippe Kémoun) -- Index.
    Abstract: Periodontitis is a disease that affects more than half the adult population in the world. Treatment is often based on ancient recommendations consisting in mechanically removing material from damaged zones. However, novel therapeutic management strategies exist, from prevention to efficient treatment, and regeneration. The need of integrative approaches to circumvent this worldwide pledge can be achieved through: A better understanding of this complex disease by promoting scientific research and a comprehensive multidisciplinary approach, including epidemiology, microbiology, immunology, physiology, therapeutics, psychology, etc. A better outreach by promoting vulgarization and recommendations for health professionals. A better information of the empowered patients, leading them to consider prevention and to take part in their therapeutic course. The book “Periodontitis: Advances in Experimental Research” includes a timely collection of chapters covering all the fields of research about periodontitis, consisting in concise reviews by the best specialists themselves and with clinical perspectives for periodontitis. Recent technological advances have allowed to explore shadowed areas of periodontology. The book “Periodontitis: Advances in Experimental Research” is a unique occasion to set a milestone for a more integrated field of periodontitis, with a broad scientific, medical, and public audience thanks to dedicated sections in each chapter: Abstract and main body (scientific audience and expert clinicians) Highlights (scientific audience and clinicians) Impact for Practice (clinicians and economical/political decision makers) Summary for Patients (patients and economical/political decision makers).
    Type of Medium: Online Resource
    Pages: XIII, 402 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030968816
    Series Statement: Advances in Experimental Medicine and Biology, 1373
    DDC: 610.72
    Language: English
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  • 72
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Medical microbiology. ; Microbial genetics. ; Industrial microbiology. ; Microbiology. ; Biomedical Research. ; Medical Microbiology. ; Microbial Genetics. ; Industrial Microbiology. ; Microbiology.
    Description / Table of Contents: Chapter 1. Epidemiology of Oral Squamous Cell Carcinoma in Indian Scenario -- Chapter 2. Risk factors for Oral Squamous Cell Carcinoma in the Indian population -- Chapter 3. Molecular Carcinopathogenesis in Oral Squamous Cell Carcinoma -- Chapter 4. Inflammation and Infection in Cancer -- Chapter 5. Role of Inflammation and Infection in Oral Squamous Cell Carcinoma -- Chapter 6. Normal Microbiome of Oral cavity -- Chapter 7. Oral Microbiome in Oral Squamous Cell Carcinoma -- Chapter 8. Microbial Dysbiosis in Oral Squamous Cell Carcinoma -- Chapter 9. Bacteria induced carcinopathogenesis in Oral Squamous Cell Carcinoma -- Chapter 10. Virus induced carcinopathogenesis in Oral Squamous Cell Carcinoma -- Chapter 11. Fungi: Culprits or Bystanders in Oral Squamous Cell Carcinoma -- Chapter 12. Microbial ‘omics’ in Oral Squamous Cell Carcinoma -- Chapter 13. Implications and Future perspectives.
    Abstract: This book helps in understanding the relationship between microorganisms and oral carcinogenesis, and the possible oncogenic mechanisms enhancing the association. The book highlights the association between oral cancer, primarily oral squamous cell carcinoma (OSCC), a major global health problem with high incidence and low survival rates with infection and inflammation. Establishing the association of the oral microbiome with cancer risk may lead to significant advances in the understanding cancer etiology, potentially opening a new research paradigm for cancer prevention. The book takes the readers through interesting topics such as the epidemiology and etiology of OSCC, the hallmarks of cancer, and the role of inflammation in OCSS. It presents the difference between the normal and diseased oral microbiome. It further describes the carcino-pathogenesis of various groups. Finally, it discusses the clinical correlation of the observations and what the future looks like for this area of research. The book is interesting for medical students, researchers and clinicians, alike. The knowledge from the book can be exploited practically and used for designing further experiments.
    Type of Medium: Online Resource
    Pages: XIII, 172 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811905926
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Medical education. ; Anatomy. ; Virtual reality. ; Augmented reality. ; Biomedical Research. ; Medical Education. ; Anatomy. ; Virtual and Augmented Reality.
    Description / Table of Contents: Chapter 1. Pandemic-Era Digital Education: Insights from an Undergraduate Medical Programme -- Chapter 2. Use of Lt Systems in Large Class Lab Delivery -- Chapter 3. COVID-19 Adaptations for Biomedical Teaching and Assessment Within the Undergraduate Dental Curriculum -- Chapter 4. One Size Does Not Fit All in Remote Anatomy Teaching -- Chapter 5. From Lecture Halls to Zoom Links: How Can Educational Theory Help Us to Deliver Effective and Engaging Teaching in an Online Environment? -- Chapter 6. Collaborative, Two-Directional Live Streaming to Deliver Hands-on Dissection Experience during the COVID-19 Lockdown -- Chapter 7. Livestreaming Can Augment the Observation of Veterinary Post-mortem Examinations -- Chapter 8. Virtual Reality for Anatomy and Surgical Teaching -- Chapter 9. Can Synchronous Online Near-Peer Teaching Offer the Same Benefits as the Face-to-Face Version When Used in Clinical Neuroanatomy Education? -- Chapter 10. COVID-19 Adaptations with Virtual Microscopy -- Chapter 11. The Challenges of Visualisation During Delivery and Assessment of Clinical Teaching Under COVID-19: A Reflective Account of Problem Solving -- Chapter 12. Not for Room 101.
    Abstract: This book focuses on the challenges to biomedical education posed by the lockdowns and restrictions to on campus teaching brought about by the COVID-19 pandemic and highlights the tools and digital visualization technologies that have been successfully developed and used for remote teaching. Biomedical education for science, medical, dental and allied health professionals relies on teaching visual and tactile knowledge using practice-based approaches. This has been delivered for decades via on-campus lectures, workshops and laboratories, teaching practical skills as well as fundamental knowledge and understanding. However, the arrival of the COVID-19 pandemic meant that education across the globe had to pivot very quickly to be able to deliver these skills and knowledge in a predominantly online environment. This brought with it many challenges, as Higher Education staff, had to adapt to deliver these visual subjects remotely. This book addresses the challenges and solutions faced by Higher Education staff in teaching visual content in distance education. Chapters include literature reviews, original research, and pedagogical reflections for a wide range of biomedical subjects, degrees such as medicine, dentistry and veterinary sciences with examples from undergraduate and postgraduate settings. The goal of the book is to provide a compendium of expertise based on evidence gathered during the COVID-19 pandemic, as well as reflections on the challenges and lessons learned from this dramatic shift in teaching. It also presents new examples of best practices that have emerged from this experience to ensure that they are not lost as we return to on-campus learning in a new era of biomedical teaching. This book will be of interest to anyone looking for a helpful reference point when designing online or blended teaching for visual practice-based subjects.
    Type of Medium: Online Resource
    Pages: X, 228 p. 56 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031171352
    Series Statement: Advances in Experimental Medicine and Biology, 1397
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Biomedical Research. ; Cell Biology.
    Description / Table of Contents: Chapter 1. Magnetic Field Parameters and Biological Sample Differences that Lead to Differential Bioeffects -- Chapter 2. Static Magnetic Field Direction-induced Differential Biological Effects -- Chapter 3. Magnetic Properties of Biological Samples -- Chapter 4. Molecular Mechanisms for Electromagnetic Field Biosensing -- Chapter 5. Controlling Cell Membrane Potential with Static Non-uniform Magnetic Fields -- Chapter 6. Impact of Static Magnetic Fields on Cells -- Chapter 7. Impact of Static Magnetic Fields on Microorganisms, Plants and Animals -- Chapter 8. Static Magnetic Fields on Human Bodies -- Chapter 9. Potential Applications of Static Magnetic Fields in Cancer Treatment -- Chapter 10. Effects of Static Magnetic Fields on Diabetes and Its Complications -- Chapter 11. Impacts of Static Magnetic Field on Bone Health -- Chapter 12. Effects of Static Magnetic Fields on the Immune System -- Chapter 13. Biological Effects of Static Magnetic Fields on the Nervous System -- Chapter 14. The Biological Effects of Long-term Static Magnetic Field Exposure -- Chapter 15. Prospects, Pitfalls, and Opportunities for Human Static Magnetic Field Therapy.
    Abstract: The book summarizes the emerging topic about the effects of SMF on biological samples ranging from single molecules, subcellular compartments, and cells to whole organisms. It also discusses the potential application of SMF in clinical treatment of cancer, pain, diabetes and other diseases. With the development and growing popularity of modern appliances like MRI in hospitals, the potential impact of magnetic fields on human health is invoking increasing concerns. At the same time, SMF has been explored in the treatment of tumor and other diseases for decades. Nevertheless, there are still some reservations and uncertainties about these treatments, which are largely due to the differential biological effects reported in the literature. These experimental inconsistencies are mainly caused by variations such as different magnetic field types, intensities, treatment time, as well as biological samples examined. The second edition added eight new chapters about new progress in this field including impacts of SMFs, magnetism of biomolecules, and potential of SMFs in the management of bone, pain, diabetes, and immune systems. This volume will help clarify some dilemmas in this field and encourage further investigations in order to achieve a better understanding of the biological effects of SMF, aiming for a rational application of SMF in clinical therapy in the near future. The book is useful for scientists, doctors, and students who are interested in magnetic fields and life sciences.
    Type of Medium: Online Resource
    Pages: XV, 420 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789811988691
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Proteins . ; Cytology. ; Proteins. ; Biomedical Research. ; Protein Biochemistry. ; Cell Biology. ; Proteins.
    Description / Table of Contents: Introduction -- Myosin Structure -- Cargo Binding by Unconventional Myosins -- Cryo-EM of Actin-Myosin Structures -- Small Molecule Effectors of Myosin Function -- Single-Molecule Biophysical Techniques to Study Actomyosin Force Transduction -- High-Speed Atomic Force Microscopy to Study Myosin Motility -- How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches -- How Actin Tracks Affect Myosin Motors -- Myosins in the Nucleus -- Myosins in Cytokinesis -- Myosins and Disease -- Myosins and Hearing -- The Actomyosin Systems in Apicomplexa -- Approaches to Identify and Characterise MYO6-Cargo Interactions -- Class IX Myosins: Motorized RhoGAP Signaling Molecules -- Myosin X -- Myosin XVI -- Myosin XVIII -- Myosin XIX.
    Abstract: Myosins are molecular motors that use the energy from ATP hydrolysis to move and exert tension on actin filaments. Although the best-known myosin is myosin II, which powers skeletal muscle contraction, there are at least two dozen classes of myosins, and cells generally express multiple isoforms. Myosins are involved in multiple cellular activities including cell structure, cell migration, intracellular trafficking, and cell-cell contact. Importantly, loss of function and mutation are associated with diseases including myopathies, hearing impairment, glomerulosclerosis, and cancer. Written by international experts in myosin motors and the approaches used to study them, this book is expected to provide a comprehensive assessment of the current status of our understanding of the structure and molecular mechanism of myosins and their cellular roles.
    Type of Medium: Online Resource
    Pages: XI, 455 p. 116 illus., 97 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030380625
    Series Statement: Advances in Experimental Medicine and Biology, 1239
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Biomedical Research. ; Pharmacology.
    Description / Table of Contents: Part 1 General and Principles of Toxicology -- A Historical Glimpse and Stalwarts -- General Toxicology -- Principles of Toxicology -- Mechanism of Toxicity -- Part 2 Disposition and Kinetics -- Disposition of Toxicants -- Toxicokinetic of Xenobiotics -- Part3 Organ Toxicity -- Target Organ Toxicity -- Part4 Non-Organ-Directed Toxicity -- chemical carcinogenesis -- Genetic Toxicology -- Developmental Toxicology -- Part5 Toxic Agents -- Pesticides -- Metals and Micronutrients -- Solvents. Gasses and Vapors -- Toxicology of Nanomaterial Particles -- Toxic Effects of Calories -- Part6 Plants, Biotoxins and Food Poisonings -- Plant Toxicity -- Biotoxins and Venomous Organisms -- Poisonous Foods and Food Poisonings -- Part7 Radioactive Materials -- Radiation and Radioactive Materials -- Part8 Applications of Toxicology -- Food Toxicology -- Ecotoxicology -- Environmental Toxicology -- Analytical and Clinical Toxicology -- Occupational Toxicology. .
    Abstract: The book provides easy-to-understand diverse specialized topics in toxicology using self- study questions and answers. The answers are in the form of text along with custom made diagrams and explanations that help the student audience to understand and grasp the matter easily. Problem Solving Questions in Toxicology is written specifically as a study guide for the toxicology board and other examinations. .
    Type of Medium: Online Resource
    Pages: XV, 346 p. 46 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504090
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Nutrition   . ; Food science. ; Chemistry, Organic. ; Biomedical Research. ; Nutrition. ; Food Science. ; Organic Chemistry.
    Description / Table of Contents: Part I: An overview of cancer and its mechanisms -- 1-A brief overview of cancer, its mechanisms, and prevention methods -- 2-MECHANISMS INVOLVED IN CARCINOGENESIS -- Part II: Functional foods/nutraceuticals as chemo preventive agents -- 3-Tomato (lycopene and β-carotene) and cancer -- 4-Essential Oils from Aromatic Plants in cancer prevention and treatment -- 5-Bee propolis (caffeic acid phenethyl ester) against cancer -- 6-Brown Algae (Fucoxanthin) Against Cancer -- 7-Cruciferous vegetables (indole-3-carbinol, isothiocyanates) against cancer -- 8-Crustacea (carotenoids namely astaxanthins) against cancer -- 9-Curcuma and breast cancer: a focus on cell signaling pathways -- 10-FRUITS AND VEGETABLES IN CANCER -- 11-Garlic: Allyl Sulfur Compounds and Cancer Prevention -- 12-Ginger (gingerols and 6-shogaol) against cancer -- 13-Saffron (crocins) against cancer -- 14-OLIVE LEAF (OLEUROPEIN) AND ITS ROLE IN CANCER: THERAPEUTIC UPDATES -- 15-Honey against cancer -- 16-Soybeans and phytoestrogen rich foods (genistein, daidzein) against cancer -- 17-Tea (catechins including (-)-epigallocatechin-3-gallate) and cancer -- 18-Probiotics and Cancer -- Part III: The role of nutrients in the prevention of cancer -- 19-Vitamins (C, D and E) against cancer -- 20-Minerals (namely selenium) and cancer -- 21-Dietary fibers/beta-glucan and cancer -- 22-Omega-3 Polyunsaturated Fatty Acids and Cancer.
    Abstract: Today's consumers are looking for food products with health-promoting roles in addition to nutritional benefits. With current research showing that nutraceuticals and functional foods rich in specific bioactives may have chemopreventative effects, these products are increasingly popular. However, while much in the literature supports the health-promoting features of these foods, few texts focus on their bioactive agents and their mode of action in cancer signaling. Nutraceuticals and Cancer Signalling: Clinical Aspects and Mode of Action explains the link between nutraceuticals and cancer in terms of clinical trials and modes of action. This book gives an overview of common cancers and their mechanisms, and the most common functional foods and their bioactive components. Individual chapters focus on specific functional foods--including tomatoes, garlic, honey, tea, yoghurt, and many more--their prominent bioactive compounds, and their mode of action in cancer signaling and chemoprevention. Recent findings on cancer-prevention roles of different vitamins and minerals are also discussed. For food scientists, nutritionists, and pharmaceutical experts looking to understand how functional foods can play a role in fighting cancer, this text serves as a one-stop reference.
    Type of Medium: Online Resource
    Pages: IX, 652 p. 52 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030740351
    Series Statement: Food Bioactive Ingredients,
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Biomedical engineering. ; Toxicology. ; Cytology. ; Biomedical Research. ; Biomedical Devices and Instrumentation. ; Toxicology. ; Cell Biology.
    Description / Table of Contents: Chapter 1. A Historical and Technological Background to Organs-on-a-Chip -- Chapter 2. Applications of microfluidics -- Chapter 3. Microfluidics based Organ-on-a-chip for cell biology studies -- Chapter 4. Microfluidics in Chemical biology -- Chapter 5. Role of microfluidics in drug delivery -- Chapter 6. Microfluidics in drug discovery -- Chapter 7. Microfludic based sensors -- Chapter 8. Background and Organs-on-a-Chip -- Chapter 9. Culture and co-culture of cells for multi organ on chip -- Chapter 10.Cells and organs on a chip in biomedical sciences -- Chapter 11. Futuristic aspects of organ on a chip -- Chapter 12. Development of Human on a chip -- Chapter 13. Multi-organ on a chip for personalized medicine -- Chapter 14. Development and application of Microfluids in organoid formation -- Chapter 15. Liver on a chip -- Chapter 16. Placenta on Chip: A Modern approach to probe feto-maternal interface -- Chapter 17. Microfluidic retina-on-chip -- Chapter 18. Heart on a chip -- Chapter 19. Kidney on a chip -- Chapter 20. Lungs on a chip -- Chapter 21. Brain on a chip -- Chapter 22. Skin on a chip -- Chapter 23. Organs-on-a-chip in preclinical studies -- Chapter 24. Application of organ on chip in blood brain barrier model -- Chapter 25. Multi organs on a chip in disease modeling -- Chapter 26. Prospects of Medical device on a chip -- Chapter 27. Lab on a chip for precision Medicine -- Chapter 28. Tumour-on-a-chip : Perfusion systems to model the extracellular breast tumour microenvironment:from tumour progression to metastasis formation -- Chapter 29. Building Human In Vitro 3D Models to Replace Animal Studies: During Drug Discovery Reearch: Scientific, Ethical and Regulatory Considerations.
    Abstract: This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.
    Type of Medium: Online Resource
    Pages: IX, 717 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811913792
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Diseases. ; Genetics. ; Immunology. ; Biomedical Research. ; Diseases. ; Genetics and Genomics. ; Immunology.
    Description / Table of Contents: Ch 1: Overview of Microbial NGS -- Ch 2: WGS for Bacterial Identification and Susceptibility Testing -- Ch 3: WGS for Bacterial Virulence Assessment -- Ch 4: Epidemiological Typing by WGS -- Ch 5: Bioinformatics Approaches for WGS Analysis -- Ch 6: WGS for Clinical Virology -- Ch 7: WGS for Clinical Mycology -- Ch 8: WGS for Clinical Parasitology -- Ch 9: Long Read Sequencing -- Ch 10: Aspects of WGS Integration -- Ch 11: Microbiome Analysis -- Ch 12: Metagenomics of Environmental Samples -- Ch 13: Clinical Metagenomics -- Ch 14: Metagenomics for Pathogen Discovery -- Ch 15: Advanced Applications for MALDI-TOF: Typing -- Ch 16: Advanced Applications for MALDI-TOF: Infectious Diseases and Antibiotic Susceptibility Testing (AST) -- Ch 17: Omics for Food and Water Microbiology -- Ch 18: Omics for Forensic and Post-Mortem Microbiology -- Ch 19: Omics for Antimicrobial Resistance Surveillance -- Ch 20: Total Laboratory Automation.
    Abstract: Various “omics” methods have recently revolutionized molecular diagnostics. Next-generation sequencing (NGS) makes it possible to sequence a human genome in just one day. Whole genome sequencing (WGS) greatly improves the ability to investigate the outbreaks of numerous pathogens. Metagenomics helps to analyze the microbiome, which aids greatly in identifying the pathogenesis of infectious diseases. Proteomic-based methods, namely matrix-assisted laser desorption-ionization time of flight mass spectrometry (MALDI-TOF-MS), have a promising role in identifying myctobacteria and fungi, and predicting antimicrobial resistance. While there are numerous scientific publications on “omics” applications for microbiology, there are relatively few books that review this topic from a clinical diagnostics perspective. This book looks at this field from a holistic viewpoint, instead of limiting by type of “omics” technology, in order to cover the body of knowledge needed for practitioners and academics interested in clinical and public health microbiology. Additionally, it addresses the management, economical, regulatory and operational aspects of integrating these technologies into routine diagnostics.
    Type of Medium: Online Resource
    Pages: VI, 240 p. 17 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030621551
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biotechnology. ; Biomedical engineering. ; Biomedical Research. ; Biotechnology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Graviola Fruit Extraction by Ionic Liquid Microwave-assisted Extraction (IL-MAE) -- Role of Ionic Liquids in the Enzyme Stabilization: A Case Study with Trichoderma ressie Cellulase -- Role of Ionic Liquids in the Processing of Lignocellulosic Biomass -- Proliferation of rat amniotic stem cell (AFSC) on modified surface microcarrier -- Application of spectroscopic methods for the analysis of non-halal meats in food products: A narrative review -- Identification of Potential Biomarkers of Porcine Gelatin -- Gamma Ray Mutagenesis on Bacteria Isolated from Shrimp Farm Mud for Microbial Fuel Cell Enhancement and Degradation of Organic Waste -- Effect of temperature on antibacterial activity and fatty acid methyl esters of Carica papaya seed extract -- Solid-state Fermentation of Agro-industrial Waste Using Heterofermentative Lacti Acid Bacteria -- Synthesis of chitosan-folic acid nanoparticles as a drug delivery system for propolis compounds.
    Abstract: This contributed volume, “Multifaceted Protocols in Biotechnology, Volume 2”, consists of multidisciplinary methods and techniques commonly used in biotechnology studies. There are two sections covered in this book – Ionic Liquid Related Techniques & Evergreen Biotechnology Techniques. A brief introduction supports each protocol to allow easy learning and implementation. The first section consists of three chapters covering studies in modern biotechnology focusing on the role of ionic liquid techniques in extracting secondary metabolites, enzyme stabilization and biomass processing. The second section covers evergreen methodologies. It comprises five chapters covering topics on microcarrier technology for cell culture; Polymerase Chain Reaction for non-halal sources detection in food; ELISA for biomarker identification; gamma ray-induced mutagenesis for enhancing microbial fuel cells; and the effect of temperature on antibacterial activity of Carica papaya seed extract. This book will be useful to graduate students, researchers, academics, and industry practitioners working in the area of biotechnology.
    Type of Medium: Online Resource
    Pages: VII, 159 p. 45 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030755799
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biophysics. ; Senses and sensation. ; Nanoscience. ; Biotechnology. ; Biomedical Research. ; Sensory Systems. ; Nanophysics. ; Chemical Bioengineering.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Bioreceptors -- Chapter 3. Catalytic Biosensors -- Chapter 4. Affinity Biosensors -- Chapter 5. Affinity Biosensors -- Chapter 6. Label-free Biosensors -- Chapter 7. Bioreceptor Immobilization -- Chapter 8. Biochips. Chapter 9. Genome Sequencing -- Chapter 10. Genome Sequencing -- Chapter 11. Micro Electrode Arrays, Implants and Organs-on-a-Chip -- Appendix.
    Abstract: This textbook describes the basic principles and mechanism of action of biosensor systems, and introduces readers to the various types of biosensors; from affinity biosensors to catalytic, optical and label-free biosensors, the most common systems are explained in detail. Dedicated advanced sections focus on biochips and genome sequencing methods as well as organs-on-a-chip. The textbook helps readers to understand the elementary components of biosensors, and to identify and illustrate each function in the biosensor information flow, from recognition to transduction and transmission. Furthermore, readers will receive guidance in critically analyzing published studies on biosensor research, helping them to develop appropriate concepts and independently propose their own solutions. The textbook is intended for master’s students in bioengineering, biophysics, biotechnology and pharmacology that need a solid grasp of biosensor system technologies and applications, as well as students in related medical technological fields.
    Type of Medium: Online Resource
    Pages: XVIII, 328 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030764692
    Series Statement: Learning Materials in Biosciences,
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Life sciences. ; Cytology. ; Internal medicine. ; Biomedical Research. ; Medical Genetics. ; Life Sciences. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: Part I. Search for novel tumor epitopes related to carbohydrates -- Chapter 1.1. The ganglioside structures: chemistry and biochemistry -- Chapter 1.2. Fucosylated proteins as cancer biomarkers -- Part II. Assembly of glycoconjugates -- Chapter 2.1. Siglec-7 and synthetic sialylpolymer -- Chapter 2.2. Role of Sialyl-Tn antigen in Cancer Metastasis -- Chapter 2.3. Insights into the Role of Chondroitin Sulfate in Cancer -- Part III. Signaling pathways modulated by glycosylation -- Chapter 3.1. Significance of FUT8in pancreatic cancer and others -- Chapter 3.2. Effects of Bullfrog sialic acid-binding lectin in cancer cells -- Part IV. Interaction between carbohydrate and carbohydrate-recognizing molecules -- Chapter 4.1. Opposite functions of mono- and disialylated glycosphingolipids on the membrane of cancer cells -- Chapter 4.2. Tumor progression through interaction of mucins with lectins and subsequent signal transduction -- Part V. Clinical trials targeting glycosignals -- Chapter 5.1. Immunotherapy of Neuroblastoma Targeting GD2 and Beyond.
    Abstract: This book, now in an extensively revised second edition, provides a comprehensive summary of the latest knowledge regarding glycosignals and a thorough analysis of their involvement in not only cancers but also other refractory conditions such as chronic inflammatory disorders. Many relevant topics are covered, including the search for novel tumor epitopes related to carbohydrates, the assembly of glycoconjugates, the modulation of signaling pathways by glycosylation, and interactions between complex carbohydrates and their recognition molecules. The role of various research approaches, for example advanced mass spectrometry, high-resolution imaging, and bioinformatics, is closely examined, and the results of novel therapeutic trials targeting glycosignals are discussed. The book will be essential reading for students and young researchers with an interest in glycoscience. In presenting new results and approaches and identifying areas for future research, it will also be of benefit for specialists in the field.
    Type of Medium: Online Resource
    Pages: VI, 238 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789811977329
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Physiology. ; Internal medicine. ; Biomedical Research. ; Medical Genetics. ; Physiology. ; Internal Medicine.
    Description / Table of Contents: Basic structure, physiology and biochemistry of connective tissues and extracellular matrix collagens -- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life -- Basic Components of Connective Tissues and Extracellular Matrix: Fibronectin, Fibrinogen, Laminin, Elastin, Fibrillins, Fibulins, Matrilins, Tenascins and Thrombospondins -- Proteoglycans and Diseases of Soft Tissues -- Growth Factor Roles in Soft Tissue Physiology and Pathophysiology -- Connective Tissue Disorders and Cardiovascular Complications: The Indomitable Role of Transforming Growth Factor-β Signaling -- The Pathophysiology and Pathogenesis of Marfan Syndrome -- Ehlers-Danlos syndromes, joint hypermobility and hypermobility spectrum disorders -- Ehlers–Danlos Syndrome Associated with Glycosaminoglycan Abnormalities -- Loeys-Dietz Syndrome -- Meester-Loeys syndrome -- Clinical and Molecular Delineation of Cutis Laxa Syndromes: Paradigms for Elastic Fiber Homeostasis -- Collagen VI Muscle Disorders: Mutation Types, Pathogenic Mechanisms and Approaches to Therapy -- Connective Tissue Disorders in Domestic Animals.
    Abstract: This volume represents a substantially revised and updated 2nd edition of a reference handbook on major structural components of soft connective tissues and a whole slew of heritable diseases of soft connective tissues. The number of clearly identifiable and distinct disorders has grown somewhat since the 1st edition in 2014, e.g., Ehlers-Danlos syndrome has now 13 entities. A brand new syndrome, Meester Loeys syndrome carrying the name of Bart Loeys was added as a companion to Loeys-Dietz syndrome. Numerous variations of cutis laxa and joint mobility disorders have been discovered taking advantage of recent advancements in genetic analysis. We have acquired better understanding of pathogenesis and biochemical changes in some other, more established entities, such as Marfan and collagen VI myopathies where better management and possible treatment are on the horizon. Even in the case of connective tissue diseases in domestic animals some progress has been made. All these updates were contributed by a group of distinguished and preeminent physicians and scientists, all of them not just working in the field but making new discoveries described by them. Readers will notice that seemingly there is an overlap among many of these disorders. And indeed, many of them, if not most are interconnected because of the prominent roles of TGFβ, of fibrillin microfibrils and collagen fibril assembly (and other molecules) playing in connective tissues physiology, and by extension in pathogenesis of many disorders described in the book. What I found particularly helpful that author(s) of each chapter bring their own perspective even when described closely related mechanism of the disease. These observations should help with diagnosis and management of such cases. The first chapters are more general, concentrating more on the physiology, structure and biochemistry of normal soft tissues. That should help in better understanding of the pathophysiology. Last but not least, the chapters are very readable, more like detective stories than dry description of genetic/biochemical defects. I do hope that basic scientists and clinicians with similar and diverse interests alike will appreciate this volume and will be inspired by it to develop their research in the field.
    Type of Medium: Online Resource
    Pages: IX, 343 p. 1 illus. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030806149
    Series Statement: Advances in Experimental Medicine and Biology, 1348
    DDC: 610.72
    Language: English
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  • 84
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Life sciences. ; Chemistry, Organic. ; Enzymology. ; Biochemistry. ; Biomedical Research. ; Life Sciences. ; Organic Chemistry. ; Enzymology. ; Biochemistry.
    Description / Table of Contents: 1. Alkanes, composition, constitution, and configuration -- 2. Functional groups -- 3. Electronic structure of organic molecules -- 4. Alkenes and alkynes -- 5. Substitutions on saturated carbon atom -- 6. Nucleophilic additions -- 7. Stereochemistry, symmetry, and molecular chirality -- 8. Derivatives of carboxylic acids -- 9. Electrophilic substitutions -- 10. Pericyclic reactions -- 11. Organic natural products -- 12. Organic supramolecular and supermolecular structures.
    Abstract: This textbook is designed for students of biology, molecular biology, ecology,medicine, agriculture, forestry and other professions where the knowledge of organic chemistry plays an important role. The work may also be of interest to non-professionals, as well as to teachers in high schools. The book consists of 13 chapters that cover the essentials of organic chemistry, including - basic principles of structure and constitution of organic compounds, - the elements of the nomenclature, - the concepts of the nature of chemical bond, - introductions in NMR and IR spectroscopy, - the concepts and main classes of the organic reaction mechanisms, - reactions and properties of common classes or organic compounds, - and the introduction to the chemistry of the natural organic products followed by basic principles of the reactions in living cells. This second edition includes revisions and suggestions made by the readers of the first edition and the author's colleagues. In addition, it includes substantial changes compared to the first edition. The chapter on Cycloaddition has been completed by including the other pericyclic reactions (sigmatropic rearrangements, electrocyclic reactions). The chapter on Organic Natural Products has been extended to include new section covering the principles of organic synthesis. New chapter "Organic Supramolecular and Supermolecular Structures" is added. This chapter covers the basic knowledge about the molecular recognition, supramolecular structures, and the mechanisms of the enzyme catalyzed reactions.
    Type of Medium: Online Resource
    Pages: XV, 205 p. 339 illus., 114 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030924386
    DDC: 610.72
    Language: English
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    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Food science. ; Nanotechnology. ; Biomedical Research. ; Food Science. ; Food Engineering. ; Food Nanotechnology.
    Description / Table of Contents: Chapter 1. Chapter 1. Food packaging industry - An introduction -- Chapter 2. Toward Smarter Food Packaging -- Chapter 3. Novel packaging development, assessment and authentication using smart technologies, non-invasive biometric sensory tools, and artificial intelligence -- Chapter 4. Biodegradable packaging materials and techniques to improve their performance -- Chapter 5. Smart Freshness Indicator for Animal Based Products Packaging - Current Status.-Chapter 6. Packaging of dairy products-Emerging strategies -- Chapter 7. Functional packaging materials for fishery products applications -- Chapter 8. Edible films and coatings: Major challenges and potential applications in food Packaging: A Review.-Chapter 9. Role of sensors to improve food/beverage packaging -- Chapter 10. Functional nanomaterials for food packaging applications -- Chapter 11. Rules and regulations related with packaging.
    Abstract: This book reviews the science and technology of food packaging and covers the potential innovations in the food packaging sector. At the same time, it highlights the issues and prospects for linking the laboratory research to the market. In addition to typical packaging requirements such as food quality, shelf life, protection, communication, and marketing, the book emphasizes the need for novel packaging materials, including biodegradable packaging for a variety of food products. A wide range of food products has been kept in focus and includes animal-based food products such as dairy products and sea foods. The book presents the next level of packaging solutions i.e., smart packaging with the applications of potential tools such as intelligent and active packaging, and includes the latest research on emerging digital technologies for packaging development, assessment, and acceptability. It further highlights the strategies including blends, reinforcing agents, cold plasma, UV light applications, chemical, and enzymatic methods and explores the new opportunities leading to improvement in the packaging performance. Smart freshness indicator applications, including gas and time-temperature indicators for quality and safety of packaged products, have been covered in detail. The book also includes the functional characteristics of edible films and coatings, including their bioactive characteristics. Finally the book presents the rules and regulation related to packaging.
    Type of Medium: Online Resource
    Pages: XI, 286 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811671968
    DDC: 610.72
    Language: English
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  • 86
    Keywords: Medicine Research. ; Biology Research. ; Virology. ; Clinical medicine Research. ; Epidemiology. ; Public health. ; Biomedical Research. ; Virology. ; Clinical Research. ; Epidemiology. ; Public Health.
    Description / Table of Contents: Clinical features, diagnostic evaluation and management of COVID-19 patients -- Outbreak of COVID-19: A Detailed Overview and Its Consequences -- A paradigm gap in host-pathogen interaction studies: Lesson from the COVID-19 pandemic -- SARS/CoV-2: Behavioral Host Manipulation -- Management of COVID-19 in the Intensive Care Unit -- First wave of Covid-19 pandemic in Italy: data and evidence -- Risk factors for COVID-19: diabetes, hypertension and obesity -- Current challenges for the effective management of the COVID-19 pandemic -- COVID-19 Outbreak Challenges in Indian Migrant Pregnant and Lactating Mothers: Learnt Lesson Demands Phronesis and Hierarchical Strategies for Such Future Pandemics -- COVID-19 and Extracorporeal Membrane Oxygenation -- COVID-19's Clinical-Pathological Evidence in Relation to its Repercussion on the Central and Peripheral Nervous System -- Anatomopathological Aspects and Clinical Correlation of COVID-19: A Systematic Review -- SARS-CoV-2 liability: the hidden mystery behind its presentation in children.
    Abstract: The book Coronavirus Therapeutics Volume II provides the most comprehensive review on contemporary knowledge on the consequences during the outbreak of Coronavirus. This also describes the clinical features, diagnostic evaluation and management of Coronavirus patients. Using an integrative approach to the understanding of paradigm gap in host-pathogen interaction studies to the management of Coronavirus patients in the Intensive Care Unit to the current challenges for the effective management of Coronavirus pandemic risk factors including diabetes, hypertension, obesity and repercussion on the central and peripheral nervous system. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 241 p. 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030851132
    Series Statement: Advances in Experimental Medicine and Biology, 1353
    DDC: 610.72
    Language: English
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  • 87
    Keywords: Medicine Research. ; Biology Research. ; Virology. ; Clinical medicine Research. ; Epidemiology. ; Biomedical Research. ; Virology. ; Clinical Research. ; Epidemiology.
    Description / Table of Contents: Origin and structural biology of Novel Coronavirus (SARS-CoV-2) -- The Molecular Virology of Coronaviruses with Special Reference to SARS-CoV-2 -- Epidemiology, transmission and molecular immunopathology of SARS-CoV-2 -- Epidemiology and Etiopathogeny of Covid-19 -- Immunological and Hematological Response in COVID-19 -- Toll-like receptors (TLRs) as Therapeutic Targets for Treating SARS-CoV-2: An Immunobiological Perspective -- Potential drug strategies to target Coronaviruses -- Possible therapeutic intervention strategies for COVID-19 by manipulating the cellular proteostasis network -- The potential impact of statins in the treatment of patients with COVID-19 infection -- Anticoronavirus activity of water-soluble pristine C60 fullerenes: in vitro and in silico screening -- Application of Nanoscale materials and nanotechnology against viral infection: A special focus on Coronaviruses -- Obesity: A Risk Factor for Covid-19 -- Cytokine Storm and Failed Resolution in COVID-19: Taking Cue from Multiple Sclerosis.
    Abstract: The book Coronavirus Therapeutics Volume I provides the most comprehensive review on contemporary knowledge on the origin, structural biology and molecular aspects of Coronaviruses. It also describes the etiology and pathogeny and therapeutic targets including vaccine drug candidates against Coronaviruses in the light of current scientific knowledge. Using an integrative approach to the understanding of Coronaviruses structure, function and immunobiology, the contributors provide a synopsis of novel mechanisms by which Coronaviruses can be treated. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 222 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030851095
    Series Statement: Advances in Experimental Medicine and Biology, 1352
    DDC: 610.72
    Language: English
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  • 88
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Internal medicine. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Internal Medicine. ; Physiology.
    Description / Table of Contents: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges -- Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer -- Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk -- Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics -- Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research -- Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions -- Ion Transport and Radioresistance -- Ion Transporting Proteins and Cancer: Progress and Perspectives.
    Abstract: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges Alina L. Capatina, Dimitris Lagos, and William J. Brackenbury Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer Ana Ramírez, Janice García-Quiroz, Luis Aguilar-Eslava, Yesennia Sánchez-Pérez, and Javier Camacho Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk Jerry J. Fan and Xi Huang Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics Umberto Banderali, Luigi Leanza, Najmeh Eskandari, and Saverio Gentile Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research Marie Potier-Cartereau, William Raoul, Gunther Weber, Karine Mahéo, Raphael Rapetti-Mauss, Maxime Gueguinou, Paul Buscaglia, Caroline Goupille, Nelig Le Goux, Souleymane Abdoul-Azize, Thierry Lecomte, Gaëlle Fromont, Aurélie Chantome, Olivier Mignen, Olivier Soriani, and Christophe Vandier Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions Jason T. Anderson, Kevin M. Huang, Maryam B. Lustberg, Alex Sparreboom, and Shuiying Hu Ion Transport and Radioresistance Bastian Roth and Stephan M. Huber Ion Transporting Proteins and Cancer: Progress and Perspectives Mustafa B. A. Djamgoz.
    Type of Medium: Online Resource
    Pages: X, 277 p. 30 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031039942
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 183
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Molecular biology. ; Metabolism. ; Genetics. ; Cytology. ; Biomedical Research. ; Molecular Biology. ; Metabolism. ; Genetics and Genomics. ; Cell Biology.
    Description / Table of Contents: Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index.
    Abstract: This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.
    Type of Medium: Online Resource
    Pages: XII, 346 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031118364
    Series Statement: Advances in Experimental Medicine and Biology, 1390
    DDC: 610.72
    Language: English
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  • 90
    Keywords: Botany. ; Food Safety measures. ; Plant diseases. ; Agriculture. ; Environment. ; Public health. ; Plant Science. ; Food Safety. ; Plant Pathology. ; Agriculture. ; Environmental Sciences. ; Public Health.
    Description / Table of Contents: Introduction -- Ancient Spores -- Spores of My Life -- Scary Spores -- Spores of the Future -- Conclusions.
    Abstract: This book aims to describe, though in a quite light way, the social role of plant diseases, letting the reader know the topical importance of plant pathology, as well as the role of plant pathologists in our society. Plant diseases caused, in the past, significant economic losses, deaths, famine, wars, and migration. Some of them marked the history of entire countries. One example among many: the potato late blight in Ireland in 1845. Today plant diseases are still the cause of deaths, often silent, in developing countries, and relevant economic losses in the industrialized ones. This book, written with much passion, neither wants to be a plant pathology text. On the contrary, it wants to describe, in simple words, often enriched by the author's personal experience, various plant diseases that, in different times and countries, did cause severe losses and damages. Besides the so-called “historical plant diseases”, in the process of writing this book, she wanted to describe also some diseases that, though not causing famine or billions of losses, because of their peculiarity, might be of interest for the readers. Thus, this book has not been conceived and written for experts, but for a broader audience, of different ages, willing to learn more about plant health and to understand the reasons why so many people in the past and nowadays choose to be plant pathologists. This is because plants produce most of the food that we consume, that we expect healthy and safe, and because plants make the world beautiful. The title “Spores” is evocative of the reproduction mean of fungi. Spores are small, light structures, often moving fast. The chapters of this book are short and concise. Just like spores!
    Type of Medium: Online Resource
    Pages: XXVI, 289 p. 174 illus., 166 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030699956
    DDC: 580
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Proteins . ; Cytology. ; Biomedical Research. ; Protein Biochemistry. ; Cell Biology.
    Description / Table of Contents: Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and Cancer Immunotherapy -- Chaperonin Hsp60 and Cancer Therapies -- Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment -- Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Therapeutics -- Multifaceted Roles of Heat Shock Factor 1 (HSF1) in Cancer -- Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer -- Heat Shock Proteins in Atrial Fibrillation -- Threading Microarrays into Novel Applications -- Regulation of Kaposi’s Sarcoma-associated Herpesvirus Biology by Host Molecular Chaperones -- Role of Heat Shock Factors in Diseases and Immunity -- Heat Shock Proteins and Pain -- Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway -- Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with diverse Cellular and Molecular Functions -- Roles of Heat Shock Proteins on Antigen Presentation -- Heat shock proteins mediate anastasis and plasticity of thermotolerant cells.
    Abstract: The book Heat Shock Proteins in Human Diseases provides the most comprehensive review on contemporary knowledge on the role of heat shock proteins (HSP) in various types of human diseases including cancer, cardiovascular disease, microbiology and inflammation. These diseases were specifically chosen due to their dismal prognosis, the survival benefit offered by the current standards do not greatly impact the overall survival statistics with the disease and are associated with toxicity. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in human diseases. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 297 p. 31 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030622893
    Series Statement: Heat Shock Proteins, 21
    DDC: 610.72
    Language: English
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  • 92
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Drug delivery systems. ; Regenerative medicine. ; Biomedical Research. ; Pharmacology. ; Drug Delivery. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Approaches Towards Synthetic Signal Transduction in Phospholipid Bilayers -- Development of Novel Versatile Theranostic Platforms Based on Titanate Nanotubes: Towards Safe Nanocarriers for Biomedical Applications -- Metal-organic Framework—Polymer Mixed-Matrix Membranes -- Insights into Adaptive Selforganized Supramolecular Structures from Molecular Modeling and Visualization -- Self-Assembled Metallacages as Drug Delivery Systems: Design Concepts and Challenge -- Functional Microporous Polymer Networks: Synthesis and Applications -- A Story on Carbon Dioxide and its Hydration -- Inverse Design and Hierarchical Multiscale Modelling of Biological Matter -- DNA-Directed Self-assembly of Macromolecular Structures -- Luminescent Complexes and their Assemblies : from Understanding to Artificial Virus -- Tailor-Made Polymers and Nanoparticles for Applications in Nanomedicine -- Squalene-based Nanomedicines : An Original and Efficient Approach for the Treatment of Neurological Disorders without Crossing the Blood-Brain Barrier -- Biodegradable Nanoparticles for Specific Drug Transport -- Multivalent rotaxanes designed as antibiofilm agents -- Measuring Ionic Transport through Lipid Bilayers -- Polymeric Carriers for Transporting Nucleic Acids - Contributions to the Field -- Smart Polymeric Materials for Drug Delivery -- Supramolecular Guanosine-quadruplex Hydrogels and Hydrogel Composites for Cell Growth Applications -- Hydrogelation of Chitosan with Monoaldehydes towards Biomaterials with Tuned Properties -- Inorganic Nanoarticles as Free Radical Scavengers -- A Microbiological Epilogue - Nosocomial Infections -- Molecular Dynamic Simulations and In Silico Analysis of Supramolecular Self-Assembled Structures -- Validation of the Non Toxicity of Non Viral Genetic -- Kinetics Transport of Ions/Water Through Nano-Scale Channels : Review And Update.
    Abstract: This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations. The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to treat the disease. Another interest concerns new ways to administer gene therapy. If genes are often delivered to their target cells by adapted viruses, the supramolecular non-viral ‘vectors’ using dynamic nano-frameworks and nano-structures are presented. In addition, it is important to reconstruct damaged tissues by mimicking natural processes in cells and polymers, such as tissue engineering and self-healing. Different options are here discussed: e.g. hydrogels based on chitosan, a carbohydrate polymer, are proving especially promising for tissue engineering and drug delivery. For controlled delivery of drugs or other biologically active compounds, hydrogels sensitive to the most important stimuli in the human body, such as temperature, pH, ionic strength, glucose and biomolecules released by the organism in pathological conditions have been developed. Finally, to assist and validate the experimental studies, computer modelling and simulations of large-sized molecular structures and systems using different molecular dynamics and quantum mechanical techniques are developed based on the experimental and chemistry synthesis. This book is of great interest for graduate students, researchers and health professionals interested in acquiring a better understanding of the mechanisms of medical treatments. In addition, it provides numerous tools to develop better therapies for human diseases.
    Type of Medium: Online Resource
    Pages: XII, 371 p. 174 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030574567
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical care. ; Human physiology. ; Biomedical Research. ; Health Care. ; Human Physiology.
    Description / Table of Contents: Targeted Drug Delivery from Titanium Implants: A Review of Challenges and Approaches -- Reliability of Magnetic Resonance Tractography in Predicting Early Clinical Improvements in Patients with Diffuse Axonal Injury -- Integrated Thermal Rehabilitation: a New Therapeutic Approach for Disabilities -- The Cat Pet as a Source Intensification of Atopic Dermatitis -- Clinical Course and Outcome of Community Acquired Bacterial Meningitis in Cancer Patients -- Influence of Coping Strategy on Perception of Anxiety and Depression in Patients with Non-Small Cell Lung Cancer -- Inflammatory Markers during Continuous High Cut-Off Hemodialysis in Patients with Septic Shock and Acute Kidney Injury -- Body Composition and Biochemical Markers of Nutrition in Non-Dialysis Dependent Chronic Kidney Disease -- Biocompatibility of hemodialysis -- Decreasing Vaccination Coverage Rates against Hepatitis B and Tuberculosis in Newborns -- Virological and Epidemiological Situation in the Influenza Epidemic Seasons 2016/17 and 2017/18 in Poland -- Epidemic Influenza Seasons from 2008 to 2018 in Poland: A Focused Review of Virological Characteristics.
    Abstract: This book addresses hot issues in the research and management of difficult-to-treat medical disorders that are commonly encountered, but for which the underlying mechanisms are often unknown. These include the adverse effects of hemodialysis and its biocompatibility in chronic kidney insufficiency, particularly related to malnutrition and inflammation, or the vulnerability of cancer patients to bacterial meningitis, the infection that remains underdiagnosed due to limited expression of symptoms. The book also covers other key topics, such as the psychological care of lung cancer patients; difficulties in the diagnosis of diffuse axonal injury in traumatic brain injury – a disorder with a poor prognosis and high mortality rate; and the virological aspects of seasonal influenza epidemic outbreaks – a perennial modern scourge. Further, it addresses recent developments in targeted drug delivery from titanium implants and a novel integrated thermal approach to rehabilitation of neurodegeneration-related disabilities. Featuring the latest interdisciplinary trends in biomedicine, this book connects research, theory and practice to help alleviate suffering caused by a variety of diseases. It is a resource for medical professionals, including academics, practitioners and all allied healthcare workers.
    Type of Medium: Online Resource
    Pages: VI, 121 p. 25 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030412197
    Series Statement: Clinical and Experimental Biomedicine, 1251
    DDC: 610.72
    Language: English
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  • 94
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Artificial intelligence. ; Bioinformatics. ; Biomedical Research. ; Artificial Intelligence. ; Bioinformatics.
    Description / Table of Contents: 1-Dimensional Convolution Neural Network Classification Technique for Gene Expression Data -- Classification of Sequences with Deep Artificial Neural Networks: Representation and Architectural Issues -- A Deep Learning Model for MicroRNA-Target Binding -- Recurrent Neural Networks Architectures for Accidental Fall Detection on Wearable Embedded Devices -- Medical Image Retrieval System using Deep Learning Techniques -- Medical Image Fusion using Deep Learning -- Deep Learning for Histopathological Image Analysis -- Innovative Deep Learning Approach for Biomedical Data Instantiation and Visualization -- Convolutional Neural Networks in Advanced Biomedical Imaging Applications -- Deep Learning for Lung Disease Detection from Chest X-Rays Images -- Deep Learning in Multi-Omics Data Integration in Cancer Diagnostic -- Using Deep Learning with Canadian Primary Care Data for Disease Diagnosis -- Brain Tumor Segmentation and Surveillance with Deep Artificial Neural Networks.
    Abstract: This book is the first overview on Deep Learning (DL) for biomedical data analysis. It surveys the most recent techniques and approaches in this field, with both a broad coverage and enough depth to be of practical use to working professionals. This book offers enough fundamental and technical information on these techniques, approaches and the related problems without overcrowding the reader's head. It presents the results of the latest investigations in the field of DL for biomedical data analysis. The techniques and approaches presented in this book deal with the most important and/or the newest topics encountered in this field. They combine fundamental theory of Artificial Intelligence (AI), Machine Learning (ML) and DL with practical applications in Biology and Medicine. Certainly, the list of topics covered in this book is not exhaustive but these topics will shed light on the implications of the presented techniques and approaches on other topics in biomedical data analysis. The book finds a balance between theoretical and practical coverage of a wide range of issues in the field of biomedical data analysis, thanks to DL. The few published books on DL for biomedical data analysis either focus on specific topics or lack technical depth. The chapters presented in this book were selected for quality and relevance. The book also presents experiments that provide qualitative and quantitative overviews in the field of biomedical data analysis. The reader will require some familiarity with AI, ML and DL and will learn about techniques and approaches that deal with the most important and/or the newest topics encountered in the field of DL for biomedical data analysis. He/she will discover both the fundamentals behind DL techniques and approaches, and their applications on biomedical data. This book can also serve as a reference book for graduate courses in Bioinformatics, AI, ML and DL. The book aims not only at professional researchers and practitioners but also graduate students, senior undergraduate students and young researchers. This book will certainly show the way to new techniques and approaches to make new discoveries.
    Type of Medium: Online Resource
    Pages: VI, 359 p. 130 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030716769
    DDC: 610.72
    Language: English
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  • 95
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Anatomy. ; Medical education. ; Virtual reality. ; Augmented reality. ; Biomedical Research. ; Anatomy. ; Medical Education. ; Virtual and Augmented Reality.
    Description / Table of Contents: Part I. Healthcare -- Chapter 1. Is It Time to FONA Friend? A Novel Mixed Reality Front of Neck Access Simulator -- Chapter 2. “Learning About Skin Breakdown” – Design, Development and Evaluation of an Augmented Reality Application to Inform about Pressure Ulcers (sores) and Moisture Lesions -- Chapter 3. The Use of 3D-Printing and Injection Moulding in the Development of a Low-Cost, Perfused Renal Malignancy Model for Training of Robot-Assisted Laparoscopic Partial Nephrectomy -- Chapter 4. The Co-IMMUNicate App: An Engaging and Entertaining Education Resource on Immunity to Respiratory Viruses -- Part II. Education -- Chapter 5. Application of AR and 3D Technology for Learning Neuroanatomy -- Chapter 6. Communicative Powers of Interactive Digital Mediums in the Field of Polyomics -- Chapter 7. SkilletonVR: Canine Skeleton VR -- Chapter 8. Using Holograms to Engage Young People with Anatomy -- Chapter 9. The Digital Dolphin: Are 3D Mobile Based and Interactive Models a Useful Aid to Volunteers on Stranding Schemes Learning the Basic Anatomy and Pathology of Cetaceans? -- Chapter 10. The Impact of the COVID Crisis on Anatomical Education: A Systematic Review.
    Abstract: This edited book explores the use of technology to enable us to visualize the life sciences in a more meaningful and engaging way. It will enable those interested in visualization techniques to gain a better understanding of the applications that can be used in visualization, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualization techniques and technologies for the historical and forensic settings. The reader will be able to explore the utilization of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences. We have something for a diverse and inclusive audience ranging from healthcare, patient education, animal health and disease and pedagogies around the use of technologies in these related fields. The first four chapters cover healthcare and detail how technology can be used to illustrate emergency surgical access to the airway, pressure sores, robotic surgery in partial nephrectomy, and respiratory viruses. The last six chapters in the education section cover augmented reality and learning neuroanatomy, historical artefacts, virtual reality in canine anatomy, holograms to educate children in cardiothoracic anatomy, 3D models of cetaceans, and the impact of the pandemic on digital anatomical educational resources.
    Type of Medium: Online Resource
    Pages: IX, 323 p. 270 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031067358
    Series Statement: Biomedical Visualization, 1
    DDC: 610.72
    Language: English
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  • 96
    Keywords: Medicine Research. ; Biology Research. ; Vocational guidance. ; Career education. ; School management and organization. ; School administration. ; Biomedical Research. ; Career Counseling. ; Career Skills. ; Organization and Leadership.
    Description / Table of Contents: Part 1: Setting the scene -- Chapter 1: Life after Academia: Launching your Pharma/Biotech Career -- Chapter 2: Competences for Pharmacists -- Chapter 3: Job and Career Opportunities in the Pharmaceutical Industry: An Overview -- Part 2: Opportunities along the drug/product life cycle -- Chapter 4: Career Opportunities in Toxicology -- Chapter 5: Job Possibilities in Clinical Research -- Chapter 6: How to Get and Develop a Career in a Market Access Role in the Medical Devices Industry -- Chapter 7: Job Opportunities in Pharmaceutical Marketing -- Chapter 8: Working in Medical Affairs and Clinical Operations: Life-Changing Careers -- Chapter 9: The Role of Medical Science Liaison -- Chapter 10: Career Development for Physicians in the Biopharmaceutical Industry -- Part 3: Opportunities in Supportive Functions -- Chapter 11: Job and Career Opportunities in Regulatory Affairs/Science -- Chapter 12: Job Opportunities in Clinical Research Quality Assurance -- Chapter 13: Job Opportunities in Quality Assurance Related to Manufacturing of Medicinal Products -- Part 4: Other Opportunities in the Pharmaceutical and Biomedical Sector -- Chapter 14: Careers Perspective in a Science and Technology Park -- Chapter 15: To be or not to be: Entrepreneurship and Enterprise Creation as a Way to Innovate in Life Sciences -- Chapter 16: How to Become a Successful Hospital and Community Pharmacist -- Part 5: Practical tips and tricks -- Chapter 17: A Successful Career in the Life Sciences Industry: How to Write your Strongest Resumé and Ace that Interview -- Chapter 18: Skill Building for Career Advancement: Public Speaking and Networking -- Chapter 19: Training Opportunities for a Career in the Pharmaceutical and Biomedical Industry/Sector.
    Abstract: Written by dedicated and active professionals from different areas of the pharmaceutical, biomedical, and medtech sectors, this book provides information on job and career opportunities in various life sciences industries. It also contains useful tips to launch your own startup. The pharmaceutical, biomedical and medical technology sectors offer a wide range of employment opportunities to talented and motivated young graduates. However, many of these employment prospects are not well known to early career scientists, who concentrate primarily on the scientific and academic content of their fields of interest. The book is divided into five parts: Part 1 provides an academic perspective that focuses on the specific preparation required in the final years of study to embark on a successful career in the pharmaceutical and biomedical industries. In Part 2, industry experts discuss employment possibilities all along the drug or product life cycle, from discovery research and development to commercialisation. Part 3 follows, highlighting opportunities in support functions such as regulatory affairs or quality assurance. Part 4 focuses on additional opportunities in the wider biomedical sector, while Part 5 contains practical tips and training opportunities for entering the pharmaceutical and biomedical industries. In the epilogue, the authors reflect on this fascinating field and its career prospects. The book offers a multidisciplinary perspective on career opportunities in the pharmaceutical and biomedical industry to a wide range of students and young life scientists. .
    Type of Medium: Online Resource
    Pages: XXI, 328 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031149115
    DDC: 610.72
    Language: English
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  • 97
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Clinical medicine Research. ; Epidemiology. ; Diseases Causes and theories of causation. ; Biomedical Research. ; Clinical Research. ; Epidemiology. ; Pathogenesis.
    Description / Table of Contents: 1. Introduction on Tuberculosis: Integrated Studies for a Complex Disease -- 2. Global Tuberculosis Epidemiology -- 3. Heterogeneity in Tuberculosis -- 4. The Unequivocal Relationship between Tuberculosis and Tobacco: Integration of Two Maladies -- 5. Relationship between Pre-existing Cancer and Tuberculosis -- 6. Laboratory Diagnosis of Tuberculosis -- 7. The Role of Diagnostic Microdevices in the Fight Against Tuberculosis -- 8. Immunodiagnostics of Tuberculosis: Recent Discoveries -- 9. Role of Bronchoscopy in Diagnostics and Treatment of Tuberculosis -- 10. Diagnosis of Childhood Tuberculosis in Low- and Middle-income Countries -- 11. Pediatric Tuberculosis: Current Evidence for Laboratory Diagnosis -- 12. A Multidisciplinary Approach Towards Finding and Treating All Tuberculosis Patients -- 13. Chemotherapy for Drug-Susceptible Tuberculosis -- 14. The Pharmacokinetic and Pharmacodynamic Properties of Antitubercular Medications -- 15. Immune Approaches In Tuberculosis Treatment -- 16. Inhalation Therapy in Pulmonary Tuberculosis -- 17. Role of Micronutrients in Tuberculosis Management -- 18. Drug Resistance in Tuberculosis: Mechanisms, Diagnosis, New Responses, and the Need for An Integrated Approach -- 19. Resistance in Tuberculosis: Molecular Mechanisms and Modulation -- 20. Personalized Tuberculosis Care for Drug-Resistant Tuberculosis -- 21. Important Targets and Inhibitors of Mycobacterium Tuberculosis -- 22. P-type ATPases: A Relevant Component in Mycobacterium tuberculosis Viability -- 23. The Challenges of Antitubercular Drug Discovery -- 24. Exploring Decaprenylphosphoryl-β-D-ribose 2’-Epimerase 1 (DprE1): A Target for Anti-Tubercular Drugs -- 25. Energy Pathways in Mycobacterium Tuberculosis -- 26. Drug Discovery for Non-Tuberculous Mycobacteria: Recent Updates -- 27. Challenges for Contact Tracing and Tuberculosis Preventive Therapy Scale-up -- 28. Exploring Problematizations Underlying Tuberculosis Control Strategies: A Cross-Country Analysis of India and Kenya -- 29. Challenges in Prevention and Management of Tuberculosis -- 30. Tuberculosis in Contacts and Healthcare Workers -- 31. Tuberculosis Among People Who Use Drugs: Multilevel Considerations for Prevention, Diagnosis, and Treatment -- 32. Anti-Tumor Necrosis Factor-α Antagonists and Tuberculosis -- 33. Breast Tuberculosis -- 34. Central Nervous System Tuberculosis: Pathogenesis, Diagnosis, and Management -- 35. Pleural Tuberculosis -- 36. Ocular Tuberculosis -- 37. Ocular Tuberculosis: Biomarkers for Risk Stratification -- 38. Bone and Joint Tuberculosis -- 39. Abdominal Tuberculosis: Pathogenesis, Clinical Features, and Diagnosis -- 40. Bovine Tuberculosis at The Interface of Cattle, Wildlife, and Humans -- 41. Evolution and Molecular Characteristics of Mycobacterium Tuberculosis and Mycobacterium Bovis -- 42. Animal Tuberculosis: Gross Lesions and Anatomopathological Diagnosis -- 43. Estimation of Microbial Mutation Rates in Tuberculosis Research -- 44. The Role of Epigenetics in the Development of Anti-Tuberculosis Drug Resistance -- 45. Multiomics Integration of Tuberculosis Pathogenesis -- 46. Lung Microbiome in Tuberculosis -- 47. The Correlation of Microbiota and Host Epigenome in Tuberculosis -- 48. The Pathogenesis and Progression of Sarcoidosis from The Standpoint of Tuberculosis -- 49. Tuberculosis: A Historical and Global Bioethical Perspective -- 50. The Problem of Tuberculosis: Myths, Stigma, and Mimics -- 51. Tuberculosis: Integrated Studies for a Complex Disease 2050.
    Abstract: Tuberculosis have been documented since antiquity and the search of the microbes that cause this disease started more than three hundred years ago. Nevertheless, tuberculosis remains an important global health issue, with millions of people affected per year in addition to millions that remain undiagnosed and untreated. Patients with tuberculosis face the full range of recurrence, reinfection, and resistance due to diagnostic, prophylactic, and therapeutic procedures that are not as effective as they should be. In addition, variability in susceptibility to tuberculosis pose a complex problem with numerous interrelated variables. This volume is devoted to the understanding of Tuberculosis focusing on its heterogeneity, its transmission, manifestations, related conditions, diagnosis, treatments, drug resistance and prevention.
    Type of Medium: Online Resource
    Pages: XXIV, 1116 p. 363 illus., 239 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031159558
    Series Statement: Integrated Science, 11
    DDC: 610.72
    Language: English
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  • 98
    Keywords: Botany. ; Food science. ; Cancer Prevention. ; Nutrition   . ; Plant Science. ; Food Science. ; Cancer Prevention. ; Nutrition.
    Description / Table of Contents: 1. Etiology of obesity, cancer, and diabetes -- 2. Pathophysiology of Obesity and Diabetes -- 3. Pathophysiology of obesity and cancer: Drugs and signaling targets -- 4. Peptides Involved in body weight regulation -- 5. Insulin resistance- a link between obesity and cancer -- 6. Role of the cytoskeletal protein, actin in various diseases -- 7. Diabetes mellitus and its management with plant-based therapy -- 8. Fruits and vegetables as sources of functional phytochemicals for the management of obesity, diabetes, and cancer -- 9. Spices in diabetes, cancer and obesity treatment -- 10. MicroRNAs as Targets of Dietary Phytochemicals in Obesity and Cancer -- 11. Natural phenolic compounds as anti-obesityand anti-cardiovascular disease agent -- 12. Harnessing the Potential of Phytochemicals for Breast Cancer Treatment.
    Abstract: This book presents comprehensive coverage on the importance of good nutrition in the treatment and management of obesity, cancer and diabetes. Naturally occurring bioactive compounds are ubiquitous in most dietary plants available to humans and provide opportunities for the management of diseases. The text provides information about the major causes of these diseases and their association with nutrition. The text also covers the role of dietary phytochemicals in drug development and their pathways. Later chapters emphasize novel bioactive compounds as anti-diabetic, anti-cancer and anti-obesity agents and describe their mechanisms to regulate cell metabolism. Written by global team of experts, Dietary Phytochemicals: A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes describes the potentials of novel phytochemicals, their sources, and underlying mechanism of action. The chapters were drawn systematically and incorporated sequentially to facilitate proper understanding. This book is intended for nutritionists, physicians, medicinal chemists, drug developers in research and development, postgraduate students and scientists in area of nutrition and life sciences.
    Type of Medium: Online Resource
    Pages: VIII, 265 p. 22 illus., 18 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030729998
    DDC: 580
    Language: English
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  • 99
    Keywords: Medicine Research. ; Biology Research. ; Biomedical engineering. ; Industrial microbiology. ; Bioinformatics. ; Synthetic Biology. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Industrial Microbiology. ; Computational and Systems Biology. ; Synthetic Biology.
    Description / Table of Contents: Part 1 Introduction to Microbial Engineering -- 1 Exploring the Potential of Microbial Engineering: The Prospect, Promise and Essence -- Part 2 Microbial Engineering Approaches -- 2 Role of System Biology in Microbial System -- 3 Synthetic Biology: Refining Human Health -- 4 Probiotic Engineering: A focus on Inflammatory Bowel Disease -- 5 Engineering microbes for smart diagnostics & Lab on Chip -- 6 Bacteriophage and Virus Engineering -- 7 CRISPR Technologies: A tool for Engineering Microbes -- Part 3 Health Benefits -- 8 Recombinant Vaccines: The Revolution Ahead -- 9 Microbe-Host Metabolic Interaction- Probiotic Approach -- 10 Designer Microbes: Oncotherapy approach -- 11 The human gut microbiome in health, disease and therapeutics -- 12 Use of Engineered Bacteria for Production of Green Chemicals & Pharmaceuticals -- 13 Fat Fighting Microbes. Part 4 Innovation & Translation -- 14 Scale-up of engineering strain for industrial applications -- 15 Affordable therapeutics through Engineered Microbes -- 16 COVID-19: Lesson Learnt from Diagnostics to therapeutics. .
    Abstract: This book highlights the recent advances in the field of microbial engineering and its application in human healthcare. It underscores the systemic and synthetic biology approaches for engineering microbes and discusses novel treatments for inflammatory bowel diseases based on engineered probiotics. The book also reviews the different options and methods for engineering microbes, ranging from recombinant DNA technology to designing microbes for targeting specific sites and delivering therapeutics. Further, it discusses genetically engineered microorganisms for smart diagnostics and describes current approaches in microbial gene editing using CRISPR-Cas9-based tools. Lastly, it summarizes the potential applications of human microbiome engineering in improving human health and explores potential strategies for scaling-up the production of engineered microbial strains for commercial purposes, as well as the challenges. Given its scope, this book is a valuable resource for students, researchers, academics and entrepreneurs interested in understanding microbial engineering for the production of commercial products.
    Type of Medium: Online Resource
    Pages: XI, 374 p. 45 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811939792
    DDC: 610.72
    Language: English
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  • 100
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Nanotechnology. ; Immunology. ; Human physiology. ; Stem cells. ; Biomedical Research. ; Nanotechnology. ; Immunology. ; Human Physiology. ; Stem Cell Biology.
    Description / Table of Contents: Chapter 1_Introduction to NanoScience, NanoTechnology, and NanoParticles -- Chapter 2_NanoScience and Bioprospecting -- Chapter 3_Nanomaterials and their use in Biomedicine -- Chapter 4_Nano scaffolds and Tissue Engineering -- Module 5_NanoScience Research in Regenerative Medicine -- Chapter 6_Nanomaterials in Food: Probiotics -- Chapter 7_Eco-compatible Single format Nanobioantibody -- Chapter 8_ NanoScience and DNA barcoding.
    Abstract: This book comprehensively reviews the history of nanotechnology, and describes the physiochemical properties of various nanoparticles and their biomedical applications. Covering the biotoxicity of nanoparticles, their bio-distribution and release kinetics, and their role in diagnosis, pre-clinical drug discovery and disease prevention, it also examines the application of nanoscaffolds in tissue engineering and as cell culture templates. Further, the book discusses several fabrication methodologies for regenerative medicine, and explores nanotechnology-based stem cell therapeutics, including stem cell transfection, stem cell delivery, and stem cell expansion for promoting tissue regeneration. Lastly, it addresses the use of DNA barcoding technology from nanosamples for the detection, identification and validation of emerging pathogens, biodiversity and ancient remnants of living specimens, and highlights various strategies for the plant-mediated synthesis of nanoparticles. Given its scope, it is a valuable reference resource for graduate students and researchers interested in understanding the diverse range of biomedical applications of nanoparticles. .
    Type of Medium: Online Resource
    Pages: XVIII, 134 p. 13 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811552748
    DDC: 610.72
    Language: English
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