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  • 1
    Online Resource
    Online Resource
    Hepatobiliary Cancers: An Interdisciplinary Approach (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Immunotherapy. ; Cancer Genetic aspects. ; Stem cells. ; Cancer Biology. ; Cancer Therapy. ; Tumour Immunology. ; Immunotherapy. ; Cancer Genetics and Genomics. ; Cancer Stem Cells.
    Description / Table of Contents: Interdisciplinary Approach in Hepatobiliary Cancers -- Liver Cancer: Interdisciplinary Approach -- The Immune System in Liver Cancer: From Beginning to Progression -- The Tumor Microenvironment in Hepatocellular Carcinoma -- Metabolic Alterations of Hepatocellular Cancer Stem Cells -- Τhe Role of Senescence in NASH-related HCC -- Regulators of Genetic Risk for the Progression of Non-alcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Reconstruction of Transcriptional Network and Signature-Based Metabolic Profiling -- Tumor Microenvironment and Immunotherapy in Advanced Biliary Tract Cancers -- Fibrosis and Immunotherapy in Hepatocellular Carcinoma -- Liver Cancer and the Curative Potential of Nanomedicine -- Locoregional Therapies for Hepatocellular Carcinoma -- Drug Resistance in Hepatocellular Carcinoma -- Liver Stereotactic Body Radiotherapy.
    Abstract: Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.
    Type of Medium: Online Resource
    Pages: XI, 365 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031445286
    Series Statement: Interdisciplinary Cancer Research, 3
    URL: https://doi.org/10.1007/978-3-031-44528-6
    DOI: 10.1007/978-3-031-44528-6
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    Therapeutic potential of Cell Cycle Kinases in Breast Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancers. ; Cancer Therapy. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Chapter 1 An introduction to breast cancer -- Chapter 2 Current treatment approaches to breast cancer. Chapter 3 Introduction to cell cycle and its regulators -- Chapter 4 Cell cycle and cancer -- Chapter 5 cell cycle dysregulation in breast cancer -- Chapter 6 Molecular Subtypes of breast cancer and CDK dysregulation -- Chapter 7 Breast tumor micro environment and CDks -- Chapter 8 CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis -- Chapter 9 CDK1 Dysregulation in Breast Cancer -- Chapter 10 CDK4/CDK6 dysregulation in estrogen positive receptor breast cancers -- Chapter 11 Therapeutic implications of CDKs in Breast Cancer -- Chapter 12 Novel CDK Inhibitors in Breast Cancer -- Chapter 13 Targeting CDKs with other chemotherapeutic drugs- A combinatorial approach -- Chapter 14 CDKs in cell-cycle progression and therapeutic strategies in Human breast cancer -- Chapter 15 CDk inhibitor for treatment of breast cancer -- Chapter 16 Response of therapy in cell cycle regulatory genes in breast cancer -- Chapter 17 Different cyclins and their significance in Breast cancer.
    Abstract: This book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.
    Type of Medium: Online Resource
    Pages: XVII, 373 p. 133 illus., 92 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811989117
    URL: https://doi.org/10.1007/978-981-19-8911-7
    DOI: 10.1007/978-981-19-8911-7
    DDC: 571.978
    Language: English
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  • 3
    Online Resource
    Online Resource
    Genetics and Epigenetics of Breast Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Genetic aspects. ; Cancer Treatment. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Cancer Therapy.
    Description / Table of Contents: Chapter 1. Breast cancer -- Chapter 1.1. Epidemiology -- Chapter 1.2. Etiology -- Chapter 1.3. Types of breast cancer -- Chapter 1.4. Signs and symptoms -- Chapter 1.5. Stages -- Chapter 1.6. Diagnosis -- Chapter 1.7. Treatment -- Chapter 2. Genetic landscape of breast carcinogenesis -- Chapter 2.1. Hormone receptor positive breast cancer -- Chapter 2.1. Her2 positive breast cancer -- Chapter 2.2. Triple negative breast cancer -- Chapter 3. Epigenetic involvement in breast carcinogenesis -- Chapter 3.1. Histone modification -- Chapter 3.2. DNA methylation -- Chapter 3.3. miRNA -- Chapter 4. Breast cancer control -- Chapter 4.1. Conventional drugs targeting Genetic and Epigenetics in Breast cancer -- Chapter 4.2. Pitfalls of conventional therapy -- Chapter 4.3. Natural remediation -- Chapter 5. Conclusion.
    Abstract: This book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. It also reviews the potential of translating the epigenetic alterations into diagnosis, prognosis, and breast cancer therapy. The initial chapters explore the epigenetics, etiology, and conventional treatment strategies for breast cancer. The subsequent chapters discuss the genetic landscape and cover three main epigenetic modulation mechanisms; histone modification, DNA methylation, and miRNA silencing. Further, the book explores the potential of epigenetic drugs in treating breast cancer. Lastly, it covers the phytochemicals targeting epigenetic modulators in breast cancer treatment. This book is an essential source for researchers and practitioners interested in exploring the potential of epigenetics modulators in breast cancer treatment.
    Type of Medium: Online Resource
    Pages: X, 87 p. 13 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811999253
    URL: https://doi.org/10.1007/978-981-19-9925-3
    DOI: 10.1007/978-981-19-9925-3
    DDC: 571.978
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cancer Stem Cells: Basic Concept and Therapeutic Implications (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Stem cells. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Stem Cells. ; Cancer Therapy. ; Cancer Biology. ; Cancer Genetics and Genomics.
    Description / Table of Contents: 1. Introduction and perspective in carcinogenesis -- 2. Origin and Development of Cancer Stem Cells -- 3. Detection and Isolation of Cancer Stem Cells -- 4. The genetic and epigenetic landscape of cancer stem cells -- 5. Metabolism of Cancer Stem Cell -- 6. Plasticity of Cancer Stem Cell -- 7. Cancer Stem Cells in Cancer Initiation and Progression -- 8. Cancer Stem Cells and Metastasis -- 9. Roles of Cancer Stem Cells in Therapy resistance and Disease Recurrence -- 10. Novel therapeutics targeting cancer stem cell surface markers -- 11. Therapeutics targeting cancer stem cells signalling pathways -- 12. Cancer stem cells therapeutics delivery and EPR effect -- 13. Immunotherapy against cancer stem cells -- 14. Engineering nanobody targeting cancer stem cells -- 15. Biological barriers for drug delivery to cancer stem cells -- 16. Cancer Stem Cell Markers in Haematological Malignancies -- 17. Diagnostic and Prognostic Significance of Cancer Stem Cells Surface Markers -- 18. Diagnostic and prognostic implications of cancer stem cells transcription factors -- 19. Diagnostic and prognostic significance of intracellular markers of CSCs in patients with cancers. .
    Abstract: This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.
    Type of Medium: Online Resource
    Pages: XVI, 372 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819931859
    URL: https://doi.org/10.1007/978-981-99-3185-9
    DOI: 10.1007/978-981-99-3185-9
    DDC: 571.978
    Language: English
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  • 5
    Online Resource
    Online Resource
    Breast Cancer: From Bench to Personalized Medicine (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Epidemiology. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Epidemiology. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Module 1_Overview of Breast Cancer -- Module 2_Cell and Molecular Biology of Breast Cancer-Diagnosis and Prognosis -- Module 3_Breast Cancer Treatment.
    Abstract: This book provides detailed information on the etiology, pathogenesis, diagnosis, prognosis, and treatment strategies for breast cancer. The first section of the book presents epidemiology, risk factors, histopathological, immunohistochemistry, and molecular subtypes of breast cancer based on the receptor status. It also discusses the association of breast cancer with other hormone-sensitive cancers. The second section of the book covers cover BRCA1 and BRCA2-associated breast carcinogenesis, early-stage progression of breast cancer, and noninvasive biomarkers for the early detection of breast cancer. It also discusses the role of epigenetic modifications and non-coding RNAs in breast cancer metastasis and explores these as the biomarkers and therapeutic targets for breast cancer therapy. Further, it discusses the role of fibrinolytic mechanisms and circulating tumor cells in breast cancer diagnosis, prognosis, and treatment. The book also provides an update on oral poly(ADP-ribose) polymerase (PARP) inhibitors to treat breast cancer. Finally, it offers potential new options for personalized therapies for breast cancer patients, including optimizing drug dosage and identifying genetic changes associated with cancer symptom occurrence and severity.
    Type of Medium: Online Resource
    Pages: XVII, 536 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811901973
    URL: https://doi.org/10.1007/978-981-19-0197-3
    DOI: 10.1007/978-981-19-0197-3
    DDC: 571.978
    Language: English
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  • 6
    Online Resource
    Online Resource
    Oncology: Genomics, Precision Medicine and Therapeutic Targets (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Genetic aspects. ; Oncology. ; Therapeutics. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Oncology. ; Therapeutics.
    Description / Table of Contents: Chapter 1 Evolution of translational cancer therapeutics -- Chapter 2 Oncology: Way forward from clinical and molecular diagnosis to treatment -- Chapter 3 Oncogenic genomics alterations in cancer patient -- Chapter 4 Altered mRNA expression profiles in cancer patients -- Chapter 5 microRNAs and long non-coding RNAs as key targets -- Chapter 6 Oncogenic alterations translated into diagnostics -- Chapter 7 Precision medicine in oncology -- Chapter 8 Precision medicine – translation of individualistic treatment in oncology -- Chapter 9Pharmacogenetics and Pharmacogenomics in Precision Medicine -- Chapter 10 Pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines -- Chapter 11 Biomarkers in Precision Medicine in oncology -- Chapter 12 Bioinformatics and biostatistics in Precision Medicine -- Chapter 13 Omics in Precision medicine -- Chapter 14 Translational therapeutic targets : from bench to clinical trials -- Chapter 15 Strength of integartive genomic alterations, precision medicine and therapeutic targets as treatment choice in patient care.
    Abstract: This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.
    Type of Medium: Online Resource
    Pages: XVI, 274 p. 23 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819915293
    URL: https://doi.org/10.1007/978-981-99-1529-3
    DOI: 10.1007/978-981-99-1529-3
    DDC: 571.978
    Language: English
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  • 7
    Online Resource
    Online Resource
    Evolutionary Dynamics of Malignancy : The Genetic and Environmental Causes of Cancer (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Animal models. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Models. ; Cancer Therapy. ; Cancer Genetics and Genomics. ; Cancer Microenvironment.
    Description / Table of Contents: Chapter 1: Cancer as a Disease of Cell Proliferation -- Chapter 2: Genetic and Chromosomal Instability -- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function -- Chapter 4: The DNA Damage Checkpoint -- Chapter 5: Dynamics of the Spindle Assembly Checkpoint -- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance -- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy -- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy -- Chapter 9: The Cancer Stem Cell and Tumour Progression -- Chapter 10: Evading the antitumour immune response -- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention -- Chapter 12: In science, all conclusions are provisional.
    Abstract: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.
    Type of Medium: Online Resource
    Pages: XIV, 269 p. 96 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031325731
    URL: https://doi.org/10.1007/978-3-031-32573-1
    DOI: 10.1007/978-3-031-32573-1
    DDC: 571.978
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cancer Diagnostics and Therapeutics : Current Trends, Challenges, and Future Perspectives (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Tumors Blood-vessels. ; Blood-vessels Growth. ; Cancer Imaging. ; Cancer Genetic aspects. ; Cancer Biology. ; Tumour Angiogenesis. ; Cancer Imaging. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Part I: Basic Background -- Chapter 1. Fighting with Cancer: A Common Man’s Dilemma -- Chapter 2. Introduction to Cell Biology and Cell Behavior in Cancer -- Chapter 3. Tumor Biology: An Introduction -- Chapter 4. Role of Angiogenesis in Tumours -- Chapter 5. Biology, Chemistry and Physics of Cancer Cell Motility and Metastasis -- Part II: Diagnostics and Theory -- Chapter 6. MRI, CT and PETSCAN: Engineer’s Perspective -- Chapter 7. Diffusion, MRI and Cancer Diagnosis: Physicist’s Outlook -- Chapter 8. Oncology: Radiation Oncologist’s View -- Chapter 9. Oncology: Biochemists’ Perspective -- Chapter 10. Oncology: Pathologist’s View -- Part III: Cancer Therapeutics -- Chapter 11. Surgical Oncology: An Overview -- Chapter 12. Medical Oncology in Cancer Treatment -- Chapter 13. Chemotherapy Effects on Immune System -- Chapter 14. Telomerase and its therapeutic implications in Cancer -- Chapter 15. Pain Management in Oncology -- Part IV: Emerging Trends in Cancer Research -- Chapter 16. New Approaches in Cancer Research: Stem-cell research, Translational Research, Immuno-therapy, and others -- Chapter 17. Cancer Cell Lines: Its Implication for Therapeutic Use -- Chapter 18. Genomics of Cancer -- Chapter 19. Chapter 19: Diabetes and Cancer -- Chapter 20. Oncology Informatics, AI, and Drug Discovery -- Chapter 21. Radiomics: Cropping More from the Images -- Part V: Epidemiology and Statistics of Cancer -- Chapter 22. Statistics in Cancer: Diagnosis, Disease Progression, Treatment Efficacy and Patient Survival Studies -- Chapter 23. Epidemiology of Cancer: Asian Perspective -- Chapter 24. Cancer Genomics and Diagnostics: Northeast Indian Scenario.
    Abstract: This book presents multiple facets of cancer biology, including cancer diagnosis, therapeutics to the latest developments in cancer informatics, and applications of artificial intelligence for improving oncologic care. The initial section of the book discusses factors contributing to the development and causes of cancer. The subsequent sections discuss the basic principle of imaging and therapeutic techniques, including MRI, CT, and positron emission tomography (PET) Scan. The book further, explores the implications of cancer chemotherapy on the immune system and emphasizes the effective management of cancer-related pain. Towards the end, it covers recent advancements in cancer treatment, including targeted therapy, immunotherapy, interventional radiotherapy, and stem cell-based therapy. Lastly, it summarizes essential strategic elements of cancer informatics for improving patient outcome.
    Type of Medium: Online Resource
    Pages: XIX, 529 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811647529
    URL: https://doi.org/10.1007/978-981-16-4752-9
    DOI: 10.1007/978-981-16-4752-9
    DDC: 571.978
    Language: English
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