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  • 1
    Keywords: Sustainability. ; Industrial design. ; Manufactures. ; Environmental sciences Social aspects. ; Industrial management Environmental aspects. ; Industrial engineering. ; Production engineering. ; Sustainability. ; Industrial Design. ; Machines, Tools, Processes. ; Environmental Social Sciences. ; Corporate Environmental Management. ; Industrial and Production Engineering.
    Description / Table of Contents: 1. Modeling local product development through multidisciplinary collaboration: A case study in Nagara, Chiba Prefecture in Japan -- 2. Developing reusable packaging for FMCG: Consumers’ perceptions of benefits and risks of refillable and returnable packaging systems -- 3. Design, evaluation, and acceptance of advanced energy efficient houses for Thailand -- 4. Explore the Framework Construction of Gamification Applied to Basic Design Teaching -- 5. Future Design Based Policy Making Card Game For High School Education -- 6. Frugal innovation in BoP communities: co-design of a technical solution to support community agriculture in Mexico -- 7. Exploring frugal innovation as an eco-design strategy: a case study of a water access solution at the BoP -- 8. A methodical concept for the development of sustainable products through radical innovations -- 9. Thinking Model for Japanese Small and Medium-sized Enterprises Innovation Explicated by OntoIS -- 10. Applying regenerative sustainability principles in manufacturing -- 11. The Potential for Reverse Innovation in Sustainable Development: A Knowledge-Directed Outlook -- 12. Finding applications for secondary raw materials -- 13. Digital product passports in circular economy – case battery passport -- 14. Data Platforms as tools for circular economy -- 15. Artificial Intelligence for Process Control In Remanufacturing -- 16. Machine Recognition of ICs in Recycling Process of Small-sized Electronics -- 17. Exploring new way media information of the product that promote sustainable consumption and production -- 18. Towards digital circular design -- 19. Circular furniture design: A case study from Swedish furniture industry -- 20. Current challenges in the lifetime extension of smartphones -- 21. Dielectric Elastomer Transducer (High Efficiency Actuator and Power Generation System) -- 22. Sustainable Services in Convenience Stores: a case study of food loss label -- 23. An Overview of Sustainability Held During 1992 to 2021 in China - An Industrial Design Perspective -- 24. Increased personal protective and Medical Equipment manufacturing to fight COVID-19: an egregious approach for the environment -- 25. Silver Recovery from Spent Photovoltaic Panel Sheets using Electrical Wire Explosion -- 26. Procedure Model to support the Recycling-oriented Design of Lithium-Ion Batteries for Electric Vehicles -- 27. Holistic Eco-design Framework Developed Through a Case Study in the Automotive Industry -- 28. Depth and detail or quick and easy? Benefits and drawbacks of two approaches to define sustainability criteria in product development -- 29. Designing Interventions for Sustainability: A conceptual framework for information scoping in the design research phase -- 30. A Sustainable Product Service System (PSS) Design for Retail Food Loss and Waste: Research Through Design -- 31. Environmental and Economical Design Problem of Upgrading and Remanufacturing Option Selection -- 32. Renewable Energy System in the Off-grid Communities: The Systems' Characteristics and Storage Technologies -- 33. Optimal Cooling Strategy for Energy Management using Multi-Temperature Acquisition Points in a Protected Cropping Facility -- 34. Price – based demand response programs considering fixed and dynamic price elasticity matrix (PEM) of demand in the wholesale market in Japan -- 35. Wind Turbine Minimum Power Loss Optimization, using Nonlinear Mathematical Programming.
    Abstract: This 2-volume book highlights cutting-edge ecodesign research and covers broad areas ranging from individual product and service design to social system design. It includes business and policy design, circular production, life cycle design and management, digitalization for sustainable manufacturing, user behavior and health, ecodesign of social infrastructure, sustainability education, sustainability indicators, and energy system design. Featuring selected papers presented at EcoDesign 2021: 12th International Symposium on Environmentally Conscious Design and Inverse Manufacturing, it also includes diverse, interdisciplinary approaches to foster ecodesign research and activities. In the context of Sustainable Development Goals (SDGs), in particular SDG 12 (Responsible Consumption and Production), it addresses design innovations for sustainable value creation, considering technological developments, legislation, and consumer lifestyles. Further, the book discusses the concept of circular economy, which aims to develop circular business models for resource efficient society by taking advantage of digital technologies including artificial intelligence, internet of things, digital twin, data analysis and simulation. Written by experts from academia and industry, Volume 1 highlights sustainable design such as product and process design, collaborative design, sustainable innovation, digital technologies, design methodology for sustainability, and energy system design. The methods, tools, and practices described are useful for readers to facilitate value creation for sustainability.
    Type of Medium: Online Resource
    Pages: X, 525 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819938186
    DDC: 304.2
    Language: English
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  • 2
    Keywords: Cancer. ; Molecular genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology. ; Cancer Biology. ; Molecular Genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology.
    Description / Table of Contents: Chapter 1. Potential Role of Biomarkers, Biosensors, Technologies and Computational Methods in Early Detection of Gastrointestinal Cancer -- Chapter 2. Biomarkers as the Promising Tools for Early Detection of Gastrointestinal Cancer -- Chapter 3. Development and Evaluation of Biomarkers for Early Detection of Cancer -- Chapter 4. Prognostic Molecular Markers for Gastrointestitinal cancer -- Chapter 5. Metabolic Markers for Early Detection of Gastrointestinal Cancer -- Chapter 6. Current Status of MicroRNA-based Biomarkers for Gastric Cancer -- Chapter 7. Genetic Susceptibility Markers of Gastrointestinal Cancer -- Chapter 8. Approaches For Early Detection Of Gastrointestinal Cancer -- Chapter 9. Biosensors and its Applications for Early Detection of Gastrointestitinal Cancer -- Chapter 10. Application of Nanotechnology in Early Detection of Gastrointestinal Cancer -- Chapter 11. Genetic Marker Identification for the Detection of Early-Onset Gastrointestitinal Cancer Through Genome Wide Association Studies -- Chapter 12. Big Data Analytics to Discover Diagnostics and Therapeutics for Gastrointestitinal Cancer -- Chapter 13. System Biology Approach for Early Prognosis of Gastrointestinal Cancer.
    Abstract: This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.
    Type of Medium: Online Resource
    Pages: XXIII, 231 p. 38 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811544316
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    DDC: 571.978
    Language: English
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  • 3
    Keywords: Sustainability. ; Information technology Management. ; Business. ; Management science. ; Artificial intelligence. ; Sustainability. ; Business IT Infrastructure. ; Business and Management. ; Artificial Intelligence.
    Description / Table of Contents: - One Planet One Compliance: Stakeholder Perception Analysis on the Efficacy of the IR Framework of ESG Disclosure -- Sustainable Influence of Instagram and Its Linkages on the Gen Z's Purchase Intention -- “Neuro Marketing: An Astonishing Addition to the Marketing World” -- Impact of Digital Transformation on Impulse Buying Behavior with Special Reference To FMCG Sector In Sustainable Environment -- A Case Study of Sustainable Service Based Marketing Strategy of Food Delivery Business in India -- A Study on Consumer Behaviour Purchasing Pattern on Durable Products in Sustainable Consumer Market -- A Study of Financial Literacy as a Sustainable Factor among Micro Entrepreneurs in Coimbatore District of Tamilnadu -- Techno Stress and Students in Sustainable Work Environment: An Empirical Study -- Indian Economic Crisis: Covid-19 Vs. Russia-Ukrainian War -- Digital Transformation in Sustainable Digital Marketing: Trends, Opportunities, and Challenges in Targeting Millennial Consumers -- A Study on Impact of Exchange Rate of Sustainable Currencies on the Indian Stock Market -- Blended Learning as a Sustainable Strategy in Digital Transformation -A Study of Challenges Faced by Parents at Sultanate of Oman -- A Study on Work-Life Balance of Teaching Women Employees Through Sustainable Training Programs in Government First-Grade Colleges in Chitradurga District -- Way Forward for Sustainable Digital Marketing: A Bibliometric Analysis -- Impact of Digital Taxation for Sustainability among Taxpayers with Special Reference to Bangalore -- A Study on Price Discovery of Jeera and Mustard Seeds Sustainable Trading In NCDEX -- Rational Influence of Debt Structure Patterns on Sustainable Profitability: A Pragmatic Evidence From Tata Steel -- Synthesis of Factors Impacting Usage of OTT Platforms: Sustainability of OTT Industry Post Pandemic -- Digital Transformation for Sustainability in Bengaluru: Is It Happening in a Smarter Way? -- Investment Perception of Working Age Population towards Crypto currency in Sustainable Financial Market. .
    Abstract: This book explores how digital technologies can be used to drive sustainable business practices and achieve long-term business success. It offers insights and practical strategies and guidance that can help businesses adapt to the digital age, optimize their operations, and create new opportunities for growth. The book further provides real-world examples that illustrate how businesses can leverage digital technologies to achieve long-term sustainability and success. The book is an essential read for business leaders, managers, academician, practitioners and entrepreneurs who are looking to drive sustainable digital transformation within their organizations. The book covers a wide range of topics, including: 1) Understanding the digital landscape: The book provides an overview of the digital technologies that are transforming business operations, such as artificial intelligence, cloud computing, and the Internet of Things. It explores how these technologies can be leveraged to create sustainable business practices that benefit both the organization and society. 2) Building a digital strategy for sustainability: The book offers guidance on how businesses can develop a digital strategy that aligns with their sustainability goals. It covers topics such as identifying digital opportunities, setting targets, and measuring performance. 3) Embedding sustainability into digital operations: The book explores how businesses can integrate sustainability into their digital operations, such as data management, supply chain management, and product design. It provides examples of companies that have successfully implemented sustainable digital practices. 4) Digital innovation for sustainability: The book discusses how businesses can use digital innovation to create new opportunities for sustainability. It covers topics such as circular economy business models, sustainable product design, and social innovation. 5) Leading for sustainable digital transformation: The book offers insights on how business leaders can drive sustainable digital transformation within their organizations. It covers topics such as leadership skills, organizational culture, and stakeholder engagement.
    Type of Medium: Online Resource
    Pages: VI, 231 p. 30 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819970582
    Series Statement: Contributions to Environmental Sciences & Innovative Business Technology,
    DDC: 304.2
    Language: English
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  • 4
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Sustainability. ; Energy policy. ; Energy and state. ; Human geography. ; Sustainability. ; Energy Policy, Economics and Management. ; Human Geography.
    Description / Table of Contents: Part One Guideline for community energy planning compilation Establishing energy planning objectives -- Energy demand analysis and prediction -- Available energy resource assessment -- Integrated energy system optimization -- Cost-effectiveness analysis of planning proposal -- Implementation management and post-assessment -- Part Two Topical subject research Building energy consumption baseline -- Models for energy demand prediction -- Relationship between community morphology and energy consumption -- Integrated energy system optimization models for community energy plan -- Energy bus system design -- Fuel cell and its application in community energy system -- Policies for community energy -- Energy system optimization in urban renewal.
    Abstract: This book systematically introduces readers to the operator method, which can be used in different stages of urban planning. Energy planning should ideally be accompanied by urban planning, ranging from comprehensive planning and detailed planning, to the design of individual construction projects. This book discusses a range of methods and models for defining energy planning objectives; analyzing and predicting energy demand; assessing available energy resources; optimizing integrated energy systems; analyzing the cost-effectiveness of proposals; implementation management; and post-assessment. Part one focuses on energy planning in different urban planning stages, while part two provides detailed discussions of key issues related to energy planning.
    Type of Medium: Online Resource
    Pages: XXI, 557 p. 254 illus., 193 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811396007
    DDC: 304.2
    Language: English
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  • 5
    Keywords: Ecology . ; Water. ; Hydrology. ; Sustainability. ; Environmental management. ; Agriculture. ; Terrestial Ecology. ; Water. ; Sustainability. ; Environmental Management. ; Agriculture.
    Description / Table of Contents: Part I. Soils, Geographical and Climatic Features, Eco-Resources, and Desertification -- Chapter 1. Potential Threats to Soil Functions and Mitigation Options for Sustainable Uses -- Chapter 2. Perspectives of Geography, Environment, and Physiography of Kuwait -- Chapter 3. Climate and Climate Change Aspects of Kuwait -- Chapter 4. Ecological Footprint and Biocapacity of Kuwait and Proposed Eco-Resources Management Strategies – A Review -- Chapter 5. Desertification – A Central Problem to Restore Ecosystems -- Part II. Water Resources, Salinization Aspects and Modeling -- Chapter 6. Current Status, Challenges and Future Management Strategies for Water Resources of Kuwait -- Chapter 7. Groundwater Salinization in Kuwait: A Major Threat to Indigenous Ecosystems -- Chapter 8. Predicting the Behavior of the Salt/Fresh-Brackish Water Transition Zone During Scavenger Well Pumping: 1. Numerical Model Development and Testing -- Chapter 9. Predicting the Behavior of the Salt/Fresh-Brackish Water Transition Zone During Scavenger Well Pumping: 2. Model Application in Kuwait and Pakistan -- Part III. Terrestrial Ecosystems and their Management -- Chapter 10. Terrestrial Habitats and Ecosystems of Kuwait -- Chapter 11. Native Vegetation and Flora of Kuwait -- Chapter 12. Wildlife of the Terrestrial Ecosystems of Kuwait -- Chapter 13. Major Threats to the Terrestrial Ecosystems and Proposed Conservation Practices -- Chapter 14. Kuwait Deserts and Ecosystems in the Context of Changing Climate -- Part IV. Agriculture, Food Security and Water Footprint of Crops -- Chapter 15. Prospective of Agricultural Farming in Kuwait and Energy-Food-Water-Climate Nexus -- Chapter 16. Agricultural Water Footprint of Major Crops in Kuwait Compared to the World Average – A Review.
    Abstract: This book is an outcome of collaborative efforts of a multidisciplinary team of scientists. The core objective of this book is to provide cross-sectoral information on the different aspects of the terrestrial environment and ecosystems of Kuwait. The book will be considered as a ready source of information for those seeking information on the terrestrial environment and ecosystems, assessment and restoration, as well as sustainable uses and management. In spite of Kuwait’s hyper-arid environment, it is rich in natural resources including a wide range of native plants, animal species, different habitats, protected areas, diversified soils and water and oil resources. While the desert of Kuwait constitutes various features, such as sand sheet, sand dunes, nebkhas, inland and coastal sabkhas, rock outcrop, wadis and farming areas, it is rich in flora and fauna (native plants, mammals, birds, reptiles, etc.). Due to changing climate, deserts of Kuwait as well as other countries are under severe threat of degradation and the degradation may be irreversible. To realize these impacts, an effort is being made to provide a ready source of information to highlight the potential threats to the terrestrial ecosystems and formulate adaptation and mitigation strategies for long-term ecosystems services in Kuwait as well as other countries located in a desert environment, such as Gulf Cooperation Council Countries, Africa and countries in the Arab region. The book includes sixteen chapters covering multidiscipline subjects (such as natural resources, climate and climate change, geographical features, terrestrial habitats, ecosystems and threats, water and soil resources, agriculture, food security, water-energy-food-climate nexus, green-grey-blue water footprints of various crops, etc.). Thus, this book is a unique resource that provides the latest scientific information in a single volume.
    Type of Medium: Online Resource
    Pages: XXV, 420 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031462627
    DDC: 577
    Language: English
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  • 6
    Keywords: Sustainability. ; Environmental management. ; Environment. ; Energy policy. ; Energy and state. ; Economic geography. ; Environmental monitoring. ; Sustainability. ; Environmental Management. ; Environmental Sciences. ; Energy Policy, Economics and Management. ; Economic Geography. ; Environmental Monitoring.
    Description / Table of Contents: Chapter 1. Use of The Nexus Approach as a Tool for Resources Management in Resilient Cities and Multi-functional Land Use Systems (Hülsmann and Jampani) -- Chapter 2. How to Best Apply Information Technology to Realize a Transdisciplinary Water-Soil-Waste Nexus Approach (Bouma) -- Chapter 3. Nutrient Recovery for Use in Agriculture: Economic Assessment of Decentralized Compost Business Model in Nairobi (Gebrezgabher, Taron and Amewu) -- Chapter 4. Sustainable and Safe Reuse of Wastewater for Food Production in Peri-urban Areas of Karnataka, India (Ramakrishna and Hanisch) -- Chapter 5. Multi-functional Historical Data for Improved Management of Reservoirs (Sang and Maina) -- Chapter 6. Usefulness of Surface Water Retention Reservoirs Inspired by 'Permaculture Design'. A Case Study in Southern Spain Using Bucket Modelling (Fiebrig and Van De Wiel) -- Chapter 7. Economic Valuation of Environmental Services Associated with Agriculture in the Watershed of Lake Lagdo, Cameroon (Nje and Ayuk) -- Chapter 8. he Energy-Water Nexus in Iran: The Political Economy of Energy Subsidies for Groundwater Pumping (Jaghdani and Kvartiuk) -- Chapter 9. Political Economy of Energy Subsidies for Groundwater Irrigation in Mendoza, Argentina (Riera, Brümmer and Gennari) -- Chapter 10. Rural Resources (Including Forestry) in the Local Development of Low Carbon Economy: a Case Study of Poland (Wiśniewski) -- Chapter 11. Opportunities and Challenges to Adopt Sustainable Watershed Management Interventions: An Overview of Experiences from Ethiopia (Tesfahunegn and Ayuk) -- Chapter 12. The Potential Contribution of Cultural Ecological Knowledge in Resources Management of a Volcanic River Basin (Ariyanti, Scholten and Edelenbos) -- Chapter 13. Nexus-Oriented Approach for Sharing Water Resources: Development of Eco-industrial Parks in the Catchment of Zayandeh Rud River, Iran (von Koerber, Raber and Schneider) -- Chapter 14. City-to-City Learning within City Networks to Cater City Needs to Climate Adaptation - Results of a Preliminary Study (Haupt, Zevenbergen and van Herk) -- Chapter 15. A Participatory Multi-stakeholder Approach to Implementing the Agenda 2030 for Sustainable Development: Theoretical Basis and Empirical Findings (Eichhorn, Hans and Schön-Chanishvili).
    Abstract: This book explores how integrated management of environmental resources via a nexus approach can help in achieving the respective Sustainable Development Goals (SDGs). It provides conceptual considerations but mainly practical examples on how to implement a nexus approach in cities and multifunctional land-use systems to increase resource use efficiency and develop a low carbon economy. After sketching out the background and conceptual outline, contributions to the book explore key aspects of the nexus implementation. Specifically, they • Demonstrate how to sustainably use organic waste and wastewater for agriculture, • Explore examples on how to manage multifunctional land-use systems including multipurpose reservoirs, • Highlight the importance of economic incentives for successful nexus implementation, and • Provide a comprehensive perspective on challenges and opportunities of implementation, considering peer-to-peer learning, indigenous knowledge, and stakeholder participation. The chapters in this book shed a new light on key aspects of the interrelation between SDGs and the nexus approach in resilient cities and multifunctional land-use systems, and provide specific examples on how to advance sustainable resources management. .
    Type of Medium: Online Resource
    Pages: VI, 256 p. 64 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030575304
    DDC: 304.2
    Language: English
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  • 7
    Keywords: Sustainability. ; Climatology. ; Agriculture. ; Human geography. ; Anthropology. ; Sustainability. ; Climate Sciences. ; Agriculture. ; Human Geography. ; Anthropology.
    Description / Table of Contents: Introduction -- Glaciers of Central Ladakh: Distribution, Changes and Relevance in the Indian Trans-Himalaya -- Floods and Debris Flows in Ladakh: Past History and Future Hazards -- Impact of 2010 Leh Cloudburst: a Psychological Perspective -- Traditional Mathematical Theories of Rainfall Prediction through Lotho as Practised in Ladakh -- The Contribution of Czech Researchers to the Botanical Survey of Ladakh -- The Adaptations of High-Altitude Mushrooms in the Cold Desert of Ladakh -- A Brief Description of Sacred Trees (lhachang) -- Environmental Change in Ladakh’s Changthang: a Local, Regional and Global Phenomenon -- Wildlife versus Livestock: Conservation Dilemma of the Pastoralists of Changthang -- Harnessing Traditional Knowledge for Wildlife Conservation in the Ladakh Trans-Himalaya -- Changing Production, Changing Consumption: Food System Transformation in Ladakh -- Eating Habits In and Around Leh Town -- Seeds of Change: A Review of Agricultural Developments in Central Zangskar -- Influences of Tourism, Indian Administration and Army on Community Identity Processes in Padum (Zangskar) -- “We Are Puppets in the Hands of Nature”: Road Construction and the Transformation of People-Environment Relationships in Ladakh -- Trade-Off between Continuity and Change in Leh District: an Emergy Evaluation in Time Series: 1999-2011.
    Abstract: The Trans-Himalayan region of Ladakh has witnessed important changes linked to its geo-strategic importance, the rapid development of means of communication with other parts of India, socio-economic transformation processes and the effects of climate change. The sixteen chapters document these key changes, ranging from melting glaciers and extreme weather events to the exponential increase in infrastructure, tourist and military activities. The book examines the impact these changes are having on the environment and on the socio-economics and identity of Ladakhi communities. The book also attempts to evaluate the likely direction of future changes, identify some of the main environmental challenges faced by Ladakh in the 21st century, and provide perspectives for sustainable development of the high mountain region.
    Type of Medium: Online Resource
    Pages: X, 283 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031424946
    Series Statement: Advances in Asian Human-Environmental Research,
    DDC: 304.2
    Language: English
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  • 8
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Immunology. ; Medical microbiology. ; Molecular genetics. ; Stem cells. ; Cell death. ; Cancer Biology. ; Immunology. ; Medical Microbiology. ; Molecular Genetics. ; Stem Cell Biology. ; Cell Death.
    Description / Table of Contents: Chapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy – An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.
    Abstract: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
    Type of Medium: Online Resource
    Pages: VII, 280 p. 38 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811569302
    DDC: 571.978
    Language: English
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  • 9
    Keywords: Sustainability. ; Industrial engineering. ; Production engineering. ; Management. ; Social choice. ; Welfare economics. ; Developmental psychology. ; Sustainability. ; Industrial and Production Engineering. ; Management. ; Social Choice and Welfare. ; Developmental Psychology.
    Description / Table of Contents: Chapter 1. Functional Unit Definition Criteria in Life Cycle Assessment and Social Life Cycle Assessment: A Discussion (Arzoumanidis) -- Chapter 2. Towards a Taxonomy For Social Impact Pathway Indicators (Weidema) -- Chapter 3. A New Scheme For The Evaluation Of Socio-Economic Performance Of Organizations: A Well-Being Indicator Approach (di Cesare) -- Chapter 4. Structure of a Net Positive Analysis For Supply Chain Social Impacts (Norris) -- Chapter 5. Weighting and Scoring In Social Life Cycle Assessment (Telles do Carmo) -- Chapter 6. Beyond a CSR Context Towards Methodological Pluralism in S-LCA: Exploring Alternative Social Theoretical Perspectives (Baumann) -- Chapter 7. Sustainable Guar Initiative, Social Impact Characterization of an Integrated Sustainable Project (vuaillat). Chapter 8. Generation, Calculation and Interpretation of Social Impacts with the Social Analysis Of Seebalance® (Saling) -- Chapter 9. Proposal of Social Indicators to Assess The Social Performance of Waste Management Systems in Developing Countries: A Brazilian Case Study (Ibañez-Forés) -- Chapter 10. Social Assessment in the Design Phase of Automotive Component Using the Product Social Impact Assessment Method (Zanchi) -- Chapter 11. Social Life Cycle Assessment in Agricultural Systems – U.S. Corn Production as a Case Study (Frank).
    Abstract: This book gives a selection of contributions from the 6th Social Life Cycle Assessment (S-LCA) Conference in Pescara, Italy. S-LCA is a social (real and potential) impact assessment method that aims to drive improvements in order to increase the value of products and services. It helps organizations to plan better, implement more effectively, and promote scale initiatives. More in general, the assessment activity also facilitates accountability and supports stakeholder communication. Consumers are greatly aware of the provenance of the goods they purchase. They have greater access to product information than ever before, also thanks to the new digital platforms. They are also empowered to make more responsible purchase decisions about what concerns sustainability aspects. Therefore the need to linger on the social aspects has been emerging recently. Although the business evolution of environmental methods and metrics has advanced significantly over the past decades, tools and metrics to estimate the social aspects of products and services are in progress. In this volume several sections provide methodological developments and tool focus, contextualizing S-LCA scientifically and explore the fields of applications. Through current development (conferences, articles, seminars and industry group publications), the method is spreading, evolving and gaining in maturity. However, it still is an evolving field, and main developments foresee, both at the level of methodology and results, interpretation and communication in order to find a path forward. S-LCA has been changing since the beginnings. From our observations as educators, researchers, practitioners, and peer reviewers in the S-LCA community, there are trends that are of importance us. .
    Type of Medium: Online Resource
    Pages: VIII, 129 p. 37 illus., 9 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030015084
    Series Statement: SpringerBriefs in Environmental Science,
    DDC: 304.2
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Oncology. ; Cancer Biology. ; Oncology.
    Description / Table of Contents: Role of specific phytochemicals against gastrointestinal malignancies -- Role of phytochemicals on growth and metastasis of GI cancer -- Cancer Stem Cells as Therapeutic Targets for Gastrointestinal cancers -- Phytochemicals plus checkpoint inhibitors in GI cancers -- Crucial role of curcumin on gut microbiota associated with GI cancers -- Cellular and Molecular mechanisms of garlic compounds in common GI cancers -- Combination of Phytochemicals with Nanotechnology for Targeting GI Cancer Therapy -- Emerging Roles of Phytochemicals in the Pathobiology and Management of Esophageal Cancer -- Gastric Cancer: Role of Phytochemicals and Tyrosine Kinase Inhibitors -- Therapeutic Efects Of Curcumin Against Colorectal Cancer -- Molecular Pathways Involved in the Pathogenesis of Pancreatic Cancer: Role of Phytochemicals in Targeting the Clinical Outcomes -- Role of Dietary Supplementation of Natural products in the Prevention and Treatment of Liver Diseases -- Emerging Roles of Phytochemicals in Hepatocellular Carcinoma -- Phytochemicals: Current Understandings of the Modern Therapeutic Approaches for Hepatocellular Carcinoma -- Index.
    Abstract: Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.
    Type of Medium: Online Resource
    Pages: XI, 340 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030484057
    DDC: 571.978
    Language: English
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