Publication Date:
1982-09-03
Description:
The transforming protein of Kirsten murine sarcoma virus (Ki-MuSV) is a virally encoded 21-kilodalton protein called p21 kis. The sequences encoding p21 kis were genetically localized to a 1.3-kilobase segment near the 5' end of the viral genome by assaying the capacity of a series of defined deletion mutants of molecularly cloned Ki-MuSV DNA to induce focal transformation of mouse cells. Nucleotide sequencing of a portion of this region has led to the identification of an open reading frame of 567 nucleotides coding for p21 kis protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsuchida, N -- Ryder, T -- Ohtsubo, E -- CA-22701/CA/NCI NIH HHS/ -- CA21124/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):937-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6287573" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
Cell Transformation, Viral
;
Cells, Cultured
;
DNA Restriction Enzymes
;
DNA, Recombinant
;
DNA, Viral/genetics
;
Genes, Viral
;
Kirsten murine sarcoma virus/*genetics
;
Mice
;
Mice, Inbred BALB C
;
Molecular Sequence Data
;
Mutation
;
Oncogene Protein p21(ras)
;
RNA, Viral/genetics
;
Sarcoma Viruses, Murine/*genetics
;
Viral Proteins/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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