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  • 1
    Online Resource
    Online Resource
    Essentials of Tissue and Cells Banking (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Internal medicine. ; Hematology. ; Biomedical Research. ; Cell Biology. ; Internal Medicine. ; Hematology.
    Description / Table of Contents: Live Donors of Tissue -- Deceased Tissue Donors -- Banking and Use of Umbilical Cord Blood -- Ocular tissue banking -- Banking of Heart Valves -- Cryopreservation and Banking of Haematopoietic Progenitor Cells -- Storage, Processing and Preservation -- Cryopreservation in tissue banking -- Sterilisation by Irradiation -- Screening the tissue donor for infectious agents -- Contamination in the Tissue Way -- Establishing a Quality System in a Tissue Establishment -- IT System requirements for Tissue and Cell Banking -- Ethical and Regulatory Aspects of Cell and Tissue Banking -- Human embryonic stem cell banking for clinical applications – 20 years from their isolation.
    Abstract: It has been 10 years since the first edition of ‘Essentials of Tissue Banking’ has been published. There is still relatively little published on the technical and scientific principles on routine tissue and cell banking based on scientific principles. The 1st edition was very successful and, after a 10 year gap, there is a need of an update and an expansion of the book’s remit. The format of the book follows that of the previous edition- split into 5 sections. Management of donors and the banking of common tissues and cells; Principles of storage and processing of tissues and cells; Ensuring the safety of the products by testing the donor, the tissues and the environment, supported by a quality system and an IT infrastructure- all working within the constraints of current regulatory and ethical environments. This edition however provides a significant update. Many the chapters have been completely rewritten by different experts. Like the 1st edition, they were given a free hand in the way they wrote their chapter, with a guideline that they had to be concise, clear and up to date. The authors were also asked to provide the scientific and technical basis that provides the rationale of the processes they describe. Also, the scope of the book has been somewhat extended. In view of the fact that many cellular therapies are now routinely practiced, 2 new chapters have been added: one on the banking of haematopoietic stem cells and one on human embryonic stem cells. They have been deliberately chosen to illustrate the extreme spectrum of cellular therapies from one of the simplest to one of the most complex. The intention of the book has remained the same: to cover and update banking of current practices in essential tissue and cell banking. It is therefore hoped that by keeping the book as concise and up to date as possible, it will find a place on the shelves of many tissue establishments.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 48 illus., 28 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030716219
    URL: https://doi.org/10.1007/978-3-030-71621-9
    DOI: 10.1007/978-3-030-71621-9
    DDC: 610.72
    Language: English
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  • 2
    Online Resource
    Online Resource
    Coenzyme Q in Aging (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Internal medicine. ; Biochemistry. ; Physiology. ; Biomedical Research. ; Cell Biology. ; Internal Medicine. ; Biochemistry. ; Physiology.
    Description / Table of Contents: Preface -- Part 1 Basics on coenzyme Q -- Introduction. The current coenzyme Q science and knowledge -- Molecular structure, biosynthesis, and distribution of coenzyme Q -- Coenzyme Q function in mitochondria -- Extramitochondrial coenzyme Q10 in aging -- Regulation of the synthesis of Coenzyme Q10 -- Part 2 Coenzyme Q in aging studies -- Coenzyme Q and aging in C. elegans -- Coenzyme Q and aging in the fruit fly Drosophila melanogaster -- The aging process and coenzyme Q: clk-1 mouse models -- Reduced coenzyme Q10 decelerates senescence and age-related hearing loss in senescence-accelerated mice by activating mitochondrial functions -- Part 3 Age-related diseases and coenzyme Q -- Coenzyme Q, mtDNA and mitochondrial dysfunction during aging -- Coenzyme Q10 and metabolic syndrome -- Coenzyme Q and age-related neurodegenerative disorders: Parkinson and Alzheimer diseases -- Immunosenescence and CoQ10 -- Coenzyme Q10 in fertility and reproduction -- Part 4 Prolongevity effectors and Coenzyme Q -- Calorie restriction, longevity and coenzyme Q -- Age dependent changes of coenzyme Q levels and its induction in experimental systems -- Effects of coenzyme Q10 supplementation on elderly people -- Index.
    Abstract: This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging. The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants. The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice. Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction. The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation. Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.
    Type of Medium: Online Resource
    Pages: XII, 369 p. 50 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030456429
    URL: https://doi.org/10.1007/978-3-030-45642-9
    DOI: 10.1007/978-3-030-45642-9
    DDC: 610.72
    Language: English
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  • 3
    Online Resource
    Online Resource
    Molecular Mechanisms in Spermatogenesis (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Reproductive health. ; Cytology. ; Biomedical Research. ; Reproductive Medicine. ; Cell Biology.
    Description / Table of Contents: Ch 1: The seminiferous epithelial cycle of spermatogenesis: Role of non-receptor protein kinases -- Ch 2: Sertoli cells: immunology and spermatogenesis -- Ch 3: Innate immunity and spermatogenesis -- Ch 4: Cell apoptosis and spermatogenesis -- Ch 5: Transcriptional regulation of spermatogenesis -- Ch 6: Sertoli cell cytoskeleton and spermatogenesis -- Ch 7: Leydig cell and spermatogenesis -- Ch 8: Cross-talk of cell junctions to support spermatogenesis -- Ch 9: Coordination of F-actin- and MT-based cytoskeletons to support spermatogenesis -- Ch 10: Regulation of the blood-testis barrier by basement membrane laminin-α2 chain -- Ch 11: Regulation of spermatogenesis by collagens -- Ch 12: Androgen regulation of spermatogenesis -- Ch 13: Use of molecular modeling to study spermatogenesis -- Ch 14: Acrosome biogenesis during spermatogenesis -- Ch 15: Stem cells and spermatogenesis -- Ch 16: Advances in our understanding of spermatogenesis in humans -- Ch 17: Leydig cell function in aging men -- Ch 18: Regulation of human spermatogenesis.
    Abstract: This new edition provides an update on the molecular mechanisms that regulate spermatogenesis. In addition to the rodent as a study model, chapters also include research on studies in humans. It includes the latest approaches of studying spermatogenesis, such as the use of bioinformatics, molecular modeling and others which are not commonly found in published materials. It also reviews the latest developments in the field, such as studies on the role of regulatory RNAs on spermatogenesis. Due to the declining fertility rate among men, a brand new chapter highlights the impact of environmental toxicants on spermatogenesis.
    Type of Medium: Online Resource
    Pages: X, 319 p. 44 illus., 40 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030777791
    Series Statement: Advances in Experimental Medicine and Biology, 1381
    URL: https://doi.org/10.1007/978-3-030-77779-1
    DOI: 10.1007/978-3-030-77779-1
    DDC: 610.72
    Language: English
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  • 4
    Online Resource
    Online Resource
    Molecular Mechanisms of Retina Pathology and Ways of its Correction (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Geriatrics. ; Ophthalmology. ; Pathology. ; Cytology. ; Pharmacy. ; Biomedical Research. ; Geriatrics. ; Ophthalmology. ; Pathology. ; Cell Biology. ; Pharmacy.
    Description / Table of Contents: Chapter 1. Literature review -- Chapter 2. Results of experimental studies of short peptides (cytogens) in ophthalmology -- Chapter 3. Results of the clinical study of short peptides (cytogens) in ophthalmology -- Conclusion.
    Abstract: This book discusses the pathology of the retina, and reviews current research on the use of cell replacement therapy and short peptides to restore functional activity in retinal neurons. As the book describes, pathologies of the retina, including age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, present a long-standing challenge in the practice of clinical ophthalmology. Modern treatment for these conditions, which lead to irreversible blindness, includes laser exposure, surgical intervention, and drugs. These treatments aim to reduce the risk of new complications in the eye; pathogenetic therapy of degenerative diseases of the retina is practically absent in current ophthalmic practice. The first section of the book reviews the molecular mechanisms of age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, and reports on methods of treatment. The second section presents the results of recent experimental studies of the effects of short peptides on pluripotent embryonic cells; on proliferative activity in retinal cells and pigment epithelium; on expression of markers of differentiation or retinal neurons and pigment epithelium; and on the course of hereditary retinal pigmentation in Campbell rats. The third section offers results of clinical studies on the effectiveness of short peptides in patients with macular degeneration, and in patients with retinitis pigmentosa. The author concludes that the regular use of peptides in the treatment of degenerative diseases of the retina can slow the progression of the pathological process and preserve the patient’s vision for some 10-15 years. In addition, in 80 percent of patients, it is possible to increase visual function by increasing visual acuity, improving the boundaries of the visual field and the fundus.
    Type of Medium: Online Resource
    Pages: VI, 90 p. 17 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030501600
    URL: https://doi.org/10.1007/978-3-030-50160-0
    DOI: 10.1007/978-3-030-50160-0
    DDC: 610.72
    Language: English
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  • 5
    Online Resource
    Online Resource
    Autophagy: Biology and Diseases : Clinical Science (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Medical sciences. ; Pharmacology. ; Biomedical Research. ; Cell Biology. ; Health Sciences. ; Pharmacology.
    Description / Table of Contents: Autophagy and Alzheimer’s Disease -- Autophagy and Parkinson’s Disease -- Autophagy and Motor Neuron Diseases -- Autophagy and Prion Disease -- Autophagy and Lysosome Storage Disorders -- Autophagy and Mitochondrial Encephalomyopathies -- Autophagy and Ischemic Stroke -- Autophagy and Hemorrhagic Stroke -- Autophagy and Polyglutamine Disease -- Autophagy and Epilepsy -- Autophagy in Neurodevelopmental Disorders -- Autophagy and Pituitary Adenoma -- Autophagy in Schizophrenia -- Autophagy and Hypertension -- Autophagy and Myocardial Ischemia -- Autophagy and Heart Failure -- Autophagy, Myocarditis and Cardiomyopathy -- Autophagy, Hyperlipidemia and Atherosclerosis -- Application of Autophagy in Cardiovascular Diseases -- Autophagy and Tumorigenesis -- Autophagy and Tumour Stem Cells -- Autophagy and Tumour Metastasis -- Autophagy and Tumor Cell Death -- Autophagy and Tumour Chemotherapy -- Autophagy and Tumour Radiotherapy -- Autophagy and Inflammatory Diseases -- Autophagy and Immune-related Diseases -- Autophagy and Autoimmune Diseases -- Autophagy and Bacterial Infection -- Autophagy and Viral Infection -- Autophagy and Thyroid Disease -- Autophagy and Obesity and Diabetes -- Autophagy and Obesity-related Reproductive Dysfunction -- Autophagy and Acute Kidney Injury -- Autophagy and Glomerular Diseases -- Autophagy and Diabetic Nephropathy -- Autophagy and Liver Diseases -- Autophagy and Gastrointestinal Diseases -- Chronic Obstructive Pulmonary Disease and Autophagy -- Autophagy and Pulmonary Fibrosis -- Asthma and Autophagy -- Autophagy and Other respiratory diseases -- Autophagy and Leukemia -- Autophagy and Lymphoma -- Autophagy and Myeloma -- The Function and Mechanisms of Autophagy in Traumatic Brain Injury -- The Function and Mechanisms of Autophagy in Spinal Cord Injury -- The Function and Mechanisms of Autophagy in Trauma of Other Parts of the Body -- The Prospects of Therapeutic Potential and Drug Development Targeting Autophagy in Cancer -- Progress of Anti-aging Drugs Targeting Autophagy -- Drug Development and Treatment of Autophagy in Other Diseases -- Systems Biology Approaches in Autophagy Research -- Natural Product Regulates Autophagy in Cancer -- Regulation of Autophagy in Neurodegenerative Diseases by Natural Products -- Regulation of Autophagy in Cardiovascular Diseases by Natural Products.
    Abstract: This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine.
    Type of Medium: Online Resource
    Pages: XXXVI, 736 p. 50 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811542725
    Series Statement: Advances in Experimental Medicine and Biology, 1207
    URL: https://doi.org/10.1007/978-981-15-4272-5
    DOI: 10.1007/978-981-15-4272-5
    DDC: 610.72
    Language: English
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  • 6
    Online Resource
    Online Resource
    Biological Effects of Static Magnetic Fields (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Biomedical Research. ; Cell Biology.
    Description / Table of Contents: Chapter 1. Magnetic Field Parameters and Biological Sample Differences that Lead to Differential Bioeffects -- Chapter 2. Static Magnetic Field Direction-induced Differential Biological Effects -- Chapter 3. Magnetic Properties of Biological Samples -- Chapter 4. Molecular Mechanisms for Electromagnetic Field Biosensing -- Chapter 5. Controlling Cell Membrane Potential with Static Non-uniform Magnetic Fields -- Chapter 6. Impact of Static Magnetic Fields on Cells -- Chapter 7. Impact of Static Magnetic Fields on Microorganisms, Plants and Animals -- Chapter 8. Static Magnetic Fields on Human Bodies -- Chapter 9. Potential Applications of Static Magnetic Fields in Cancer Treatment -- Chapter 10. Effects of Static Magnetic Fields on Diabetes and Its Complications -- Chapter 11. Impacts of Static Magnetic Field on Bone Health -- Chapter 12. Effects of Static Magnetic Fields on the Immune System -- Chapter 13. Biological Effects of Static Magnetic Fields on the Nervous System -- Chapter 14. The Biological Effects of Long-term Static Magnetic Field Exposure -- Chapter 15. Prospects, Pitfalls, and Opportunities for Human Static Magnetic Field Therapy.
    Abstract: The book summarizes the emerging topic about the effects of SMF on biological samples ranging from single molecules, subcellular compartments, and cells to whole organisms. It also discusses the potential application of SMF in clinical treatment of cancer, pain, diabetes and other diseases. With the development and growing popularity of modern appliances like MRI in hospitals, the potential impact of magnetic fields on human health is invoking increasing concerns. At the same time, SMF has been explored in the treatment of tumor and other diseases for decades. Nevertheless, there are still some reservations and uncertainties about these treatments, which are largely due to the differential biological effects reported in the literature. These experimental inconsistencies are mainly caused by variations such as different magnetic field types, intensities, treatment time, as well as biological samples examined. The second edition added eight new chapters about new progress in this field including impacts of SMFs, magnetism of biomolecules, and potential of SMFs in the management of bone, pain, diabetes, and immune systems. This volume will help clarify some dilemmas in this field and encourage further investigations in order to achieve a better understanding of the biological effects of SMF, aiming for a rational application of SMF in clinical therapy in the near future. The book is useful for scientists, doctors, and students who are interested in magnetic fields and life sciences.
    Type of Medium: Online Resource
    Pages: XV, 420 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789811988691
    URL: https://doi.org/10.1007/978-981-19-8869-1
    DOI: 10.1007/978-981-19-8869-1
    DDC: 610.72
    Language: English
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  • 7
    Online Resource
    Online Resource
    Myosins : A Superfamily of Molecular Motors (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Proteins . ; Cytology. ; Proteins. ; Biomedical Research. ; Protein Biochemistry. ; Cell Biology. ; Proteins.
    Description / Table of Contents: Introduction -- Myosin Structure -- Cargo Binding by Unconventional Myosins -- Cryo-EM of Actin-Myosin Structures -- Small Molecule Effectors of Myosin Function -- Single-Molecule Biophysical Techniques to Study Actomyosin Force Transduction -- High-Speed Atomic Force Microscopy to Study Myosin Motility -- How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches -- How Actin Tracks Affect Myosin Motors -- Myosins in the Nucleus -- Myosins in Cytokinesis -- Myosins and Disease -- Myosins and Hearing -- The Actomyosin Systems in Apicomplexa -- Approaches to Identify and Characterise MYO6-Cargo Interactions -- Class IX Myosins: Motorized RhoGAP Signaling Molecules -- Myosin X -- Myosin XVI -- Myosin XVIII -- Myosin XIX.
    Abstract: Myosins are molecular motors that use the energy from ATP hydrolysis to move and exert tension on actin filaments. Although the best-known myosin is myosin II, which powers skeletal muscle contraction, there are at least two dozen classes of myosins, and cells generally express multiple isoforms. Myosins are involved in multiple cellular activities including cell structure, cell migration, intracellular trafficking, and cell-cell contact. Importantly, loss of function and mutation are associated with diseases including myopathies, hearing impairment, glomerulosclerosis, and cancer. Written by international experts in myosin motors and the approaches used to study them, this book is expected to provide a comprehensive assessment of the current status of our understanding of the structure and molecular mechanism of myosins and their cellular roles.
    Type of Medium: Online Resource
    Pages: XI, 455 p. 116 illus., 97 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030380625
    Series Statement: Advances in Experimental Medicine and Biology, 1239
    URL: https://doi.org/10.1007/978-3-030-38062-5
    DOI: 10.1007/978-3-030-38062-5
    DDC: 610.72
    Language: English
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  • 8
    Online Resource
    Online Resource
    Microfluidics and Multi Organs on Chip (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Biomedical engineering. ; Toxicology. ; Cytology. ; Biomedical Research. ; Biomedical Devices and Instrumentation. ; Toxicology. ; Cell Biology.
    Description / Table of Contents: Chapter 1. A Historical and Technological Background to Organs-on-a-Chip -- Chapter 2. Applications of microfluidics -- Chapter 3. Microfluidics based Organ-on-a-chip for cell biology studies -- Chapter 4. Microfluidics in Chemical biology -- Chapter 5. Role of microfluidics in drug delivery -- Chapter 6. Microfluidics in drug discovery -- Chapter 7. Microfludic based sensors -- Chapter 8. Background and Organs-on-a-Chip -- Chapter 9. Culture and co-culture of cells for multi organ on chip -- Chapter 10.Cells and organs on a chip in biomedical sciences -- Chapter 11. Futuristic aspects of organ on a chip -- Chapter 12. Development of Human on a chip -- Chapter 13. Multi-organ on a chip for personalized medicine -- Chapter 14. Development and application of Microfluids in organoid formation -- Chapter 15. Liver on a chip -- Chapter 16. Placenta on Chip: A Modern approach to probe feto-maternal interface -- Chapter 17. Microfluidic retina-on-chip -- Chapter 18. Heart on a chip -- Chapter 19. Kidney on a chip -- Chapter 20. Lungs on a chip -- Chapter 21. Brain on a chip -- Chapter 22. Skin on a chip -- Chapter 23. Organs-on-a-chip in preclinical studies -- Chapter 24. Application of organ on chip in blood brain barrier model -- Chapter 25. Multi organs on a chip in disease modeling -- Chapter 26. Prospects of Medical device on a chip -- Chapter 27. Lab on a chip for precision Medicine -- Chapter 28. Tumour-on-a-chip : Perfusion systems to model the extracellular breast tumour microenvironment:from tumour progression to metastasis formation -- Chapter 29. Building Human In Vitro 3D Models to Replace Animal Studies: During Drug Discovery Reearch: Scientific, Ethical and Regulatory Considerations.
    Abstract: This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.
    Type of Medium: Online Resource
    Pages: IX, 717 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811913792
    URL: https://doi.org/10.1007/978-981-19-1379-2
    DOI: 10.1007/978-981-19-1379-2
    DDC: 610.72
    Language: English
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  • 9
    Online Resource
    Online Resource
    Glycosignals in Cancer : Molecular Assembly and Recognition (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Life sciences. ; Cytology. ; Internal medicine. ; Biomedical Research. ; Medical Genetics. ; Life Sciences. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: Part I. Search for novel tumor epitopes related to carbohydrates -- Chapter 1.1. The ganglioside structures: chemistry and biochemistry -- Chapter 1.2. Fucosylated proteins as cancer biomarkers -- Part II. Assembly of glycoconjugates -- Chapter 2.1. Siglec-7 and synthetic sialylpolymer -- Chapter 2.2. Role of Sialyl-Tn antigen in Cancer Metastasis -- Chapter 2.3. Insights into the Role of Chondroitin Sulfate in Cancer -- Part III. Signaling pathways modulated by glycosylation -- Chapter 3.1. Significance of FUT8in pancreatic cancer and others -- Chapter 3.2. Effects of Bullfrog sialic acid-binding lectin in cancer cells -- Part IV. Interaction between carbohydrate and carbohydrate-recognizing molecules -- Chapter 4.1. Opposite functions of mono- and disialylated glycosphingolipids on the membrane of cancer cells -- Chapter 4.2. Tumor progression through interaction of mucins with lectins and subsequent signal transduction -- Part V. Clinical trials targeting glycosignals -- Chapter 5.1. Immunotherapy of Neuroblastoma Targeting GD2 and Beyond.
    Abstract: This book, now in an extensively revised second edition, provides a comprehensive summary of the latest knowledge regarding glycosignals and a thorough analysis of their involvement in not only cancers but also other refractory conditions such as chronic inflammatory disorders. Many relevant topics are covered, including the search for novel tumor epitopes related to carbohydrates, the assembly of glycoconjugates, the modulation of signaling pathways by glycosylation, and interactions between complex carbohydrates and their recognition molecules. The role of various research approaches, for example advanced mass spectrometry, high-resolution imaging, and bioinformatics, is closely examined, and the results of novel therapeutic trials targeting glycosignals are discussed. The book will be essential reading for students and young researchers with an interest in glycoscience. In presenting new results and approaches and identifying areas for future research, it will also be of benefit for specialists in the field.
    Type of Medium: Online Resource
    Pages: VI, 238 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9789811977329
    URL: https://doi.org/10.1007/978-981-19-7732-9
    DOI: 10.1007/978-981-19-7732-9
    DDC: 610.72
    Language: English
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  • 10
    Online Resource
    Online Resource
    Nuclear Receptors in Human Health and Disease (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Molecular biology. ; Metabolism. ; Genetics. ; Cytology. ; Biomedical Research. ; Molecular Biology. ; Metabolism. ; Genetics and Genomics. ; Cell Biology.
    Description / Table of Contents: Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index.
    Abstract: This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.
    Type of Medium: Online Resource
    Pages: XII, 346 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031118364
    Series Statement: Advances in Experimental Medicine and Biology, 1390
    URL: https://doi.org/10.1007/978-3-031-11836-4
    DOI: 10.1007/978-3-031-11836-4
    DDC: 610.72
    Language: English
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  • 11
    Online Resource
    Online Resource
    Heat Shock Proteins in Human Diseases (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Proteins . ; Cytology. ; Biomedical Research. ; Protein Biochemistry. ; Cell Biology.
    Description / Table of Contents: Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and Cancer Immunotherapy -- Chaperonin Hsp60 and Cancer Therapies -- Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment -- Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Therapeutics -- Multifaceted Roles of Heat Shock Factor 1 (HSF1) in Cancer -- Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer -- Heat Shock Proteins in Atrial Fibrillation -- Threading Microarrays into Novel Applications -- Regulation of Kaposi’s Sarcoma-associated Herpesvirus Biology by Host Molecular Chaperones -- Role of Heat Shock Factors in Diseases and Immunity -- Heat Shock Proteins and Pain -- Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway -- Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with diverse Cellular and Molecular Functions -- Roles of Heat Shock Proteins on Antigen Presentation -- Heat shock proteins mediate anastasis and plasticity of thermotolerant cells.
    Abstract: The book Heat Shock Proteins in Human Diseases provides the most comprehensive review on contemporary knowledge on the role of heat shock proteins (HSP) in various types of human diseases including cancer, cardiovascular disease, microbiology and inflammation. These diseases were specifically chosen due to their dismal prognosis, the survival benefit offered by the current standards do not greatly impact the overall survival statistics with the disease and are associated with toxicity. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in human diseases. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 297 p. 31 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030622893
    Series Statement: Heat Shock Proteins, 21
    URL: https://doi.org/10.1007/978-3-030-62289-3
    DOI: 10.1007/978-3-030-62289-3
    DDC: 610.72
    Language: English
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  • 12
    Online Resource
    Online Resource
    Oxidative Stress : Human Diseases and Medicine (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Pharmacology. ; Biomedical Research. ; Cell Biology. ; Pharmacology.
    Description / Table of Contents: Oxidative stress and anti-oxidant strategies in human diseases -- Oxidative stress in the tumorimmune microenvironment -- Oxidative stress-mediated stem cell aging -- Stress proteins: Biological functions, human diseases and virus infections -- Importance of mitochondrial quality controls in Parkinson’s disease: the potential interplay of mitochondrial unfolded protein response and mitophagy -- Autophagy in cellular stress responses -- Cysteine metabolism in cancer progression and therapy resistance -- Stress and circadians -- ROS, glucose and lipid metabolism -- Drug repurposing: An avenue towards stress medicine in cancer therapy -- Redox regulation of metabolic enzymes in cancer -- Stress and inflammation -- Oxidative stress in cell signaling and cell fate determination under glucose starvation.
    Abstract: This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.
    Type of Medium: Online Resource
    Pages: VI, 323 p. 43 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811605222
    URL: https://doi.org/10.1007/978-981-16-0522-2
    DOI: 10.1007/978-981-16-0522-2
    DDC: 610.72
    Language: English
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  • 13
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    Online Resource
    Ferroptosis: Mechanism and Diseases (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Cytology. ; Lipids. ; Biomedical Research. ; Medical Genetics. ; Cell Biology. ; Cell Biology. ; Lipidology.
    Description / Table of Contents: Foreword -- Ferroptosis: Concepts and Definitions -- Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT inhibitors -- Iron Homeostasis and Metabolism: Two Sides of a Coin -- The Role of NCOA4-mediated Ferritinophagy in Ferroptosis -- Emerging Role for Ferroptosis in Infectious Diseases -- Small Molecule Regulators of Ferroptosis -- Necroptosis, The other main Caspase-Independent Cell Death.
    Abstract: This book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ferroptosis. It will enable readers to choose molecules for experimental design for in vitro and in vivo studies of ferroptosis. Furthermore, this volume highlights the aspects of iron metabolism and its connection to ferritinophagy, a ferritin selective autophagy, with profound implications in neurodegenerative diseases such as Alzheimer, Parkinson, Huntington and ALS. Lastly, it describes necroptosis, another important form of cell death, along with its connections to human disorders and potential crosstalk with ferroptosis. While covering basic concepts, the book delves into mechanisms and modulation of ferroptosis for treating a wide variety of human diseases thus offering a valuable and informative resource for both, scientists and clinical researchers.
    Type of Medium: Online Resource
    Pages: IX, 140 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030620264
    Series Statement: Advances in Experimental Medicine and Biology, 1301
    URL: https://doi.org/10.1007/978-3-030-62026-4
    DOI: 10.1007/978-3-030-62026-4
    DDC: 610.72
    Language: English
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  • 14
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    Online Resource
    Inflammation and Metastasis (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Human physiology. ; Immunology. ; Cytology. ; Biomedical Research. ; Human Physiology. ; Immunology. ; Cell Biology.
    Description / Table of Contents: Chapter 1 General Thinking About Inflammation -- Chapter 2 Inflammation from the Standpoint of Leukocytes -- Chapter 3 Vessels and Coagulation -- Chapter 4 Sterile Inflammation -- Chapter 5 Issue of Self and Non-self -- Chapter 6 Extension of Endogenous Field -- Chapter 7 Evidence for Existence of Endogenous TLR4 Ligands -- Chapter 8 Autoinflammatory Disorders -- Chapter 9 Cancer in General -- Chapter 10 Basic Research -- Chapter 11 Tumor Microenvironment -- Chapter 12 Whole-Body Matter -- Chapter 13 Premetastatic Microenvironment -- Chapter 14 What Is Homeostasis? -- Chapter 15 Explanation of Metastasis by Homeostatic Inflammation -- Chapter 16 Therapeutic Potential.
    Abstract: This book, now in a thoroughly revised and updated second edition, provides the latest information on cancer metastasis from the perspective of inflammation and presents new ideas on the complicated mechanisms of metastasis and potential therapeutic targets. Key features include discussion of mechanisms recently identified to be involved in the resolution phase of inflammation, presentation of the latest evidence regarding the roles of endogenous TLR4 ligands in metastasis, and thorough explanation of the concept of homeostatic inflammation and current understanding of the significance of its dysregulation for metastasis. Structure-based thinking is another important element of the book, and it is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, at the center of which cancer is located. Examples of the many additional specific topics covered in this edition include the functional involvement of new types of RNA in cancer, the insights offered by recent advances in bioinformatics, and the potential of a casein kinase 1α inhibitor in the treatment of acute myeloid leukemia. The book will be a valuable update and resource for both experienced and younger researchers. Homeostasis, originated from an idea of internal milieu by Claude Bernard, is eventually maintained by endogenous elements. The essential features of inflammation are leukocyte mobilization and increased vascular permeability, which could take place in many homeostatic or physiological conditions at low levels. Homeostatic inflammation is a concept to explain pathological settings such as metastasis in which irrespective of its level those inflammatory features are misused with endogenous molecules (see Chap. 14,15). As inflammation comprises many biological fields, targeting a single molecule for a disease could potentially make a therapeutic contribution to other diseases. For example, one focus is applied here to the roles of calprotectin in lung metastasis, which is implicated in psychiatric disorders and COVID-19 as shown by recent evidence.
    Type of Medium: Online Resource
    Pages: XX, 518 p. 81 illus., 33 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9789811617577
    URL: https://doi.org/10.1007/978-981-16-1757-7
    DOI: 10.1007/978-981-16-1757-7
    DDC: 610.72
    Language: English
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  • 15
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    Online Resource
    Cell Culture Engineering and Technology : In appreciation to Professor Mohamed Al-Rubeai (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Biology Technique. ; Regenerative medicine. ; Biomedical engineering. ; Biomedical Research. ; Cell Biology. ; Biological Techniques. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Biopharmaceuticals Produced from Cultivated Mammalian Cells -- Remote Control of Mammalian Therapeutic Designer Cells -- Next generation cell engineering using microRNAs -- An Omic’s data-driven approach towards engineering mammalian cell factories and bioprocesses for biopharmaceutical production -- Redesigning spent media from cell culture bioprocess to feed new bacterial fermentations -- Monoclonal antibody glycoengineering for biopharmaceutical quality assurance -- Next-generation cell engineering platform for improving recombinant protein production in mammalian cells -- Manufacturing human pluripotent stem cells and differentiated progenitors -- Biomanufacturing of Mesenchymal Stromal Cell for Therapeutic Applications -- Process Design for hMSC Products in Stirred Tank Bioreactors -- Bio-production of Adeno-associated virus for gene therapy -- Scale-up (and scale-down) of CHO cell culture, with a focus on how to adjust the various culture parameters/setpoints across different systems from lab-scale to manufacturing-scale -- Intensified and Continuous mAb Production with Single-Use Systems -- Mathematical modelling of cell culture processes -- Model-assisted design concepts for mammalian cell culture processes -- Bioprocess monitoring and control -- Industrial Monitoring of Cell Culture.
    Abstract: This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.
    Type of Medium: Online Resource
    Pages: X, 550 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030798710
    Series Statement: Cell Engineering, 10
    URL: https://doi.org/10.1007/978-3-030-79871-0
    DOI: 10.1007/978-3-030-79871-0
    DDC: 610.72
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  • 16
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    Online Resource
    Advances in Nanomaterials-based Cell Biology Research (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Nanobiotechnology. ; Biomedical Research. ; Cell Biology. ; Nanobiotechnology.
    Description / Table of Contents: Chapter 1. Nanomaterials and Stem Cells for Bone Tissue Engineering -- Chapter 2. The Application of Nanomaterial in Skeletal Muscle Regeneration -- Chapter 3. Application of Nanomaterials in Neurodegenerative Diseases -- Chapter 4. Application of Nano Drug Delivery Systems in Inhibition of Tumors and Cancer Stem Cells -- Chapter 5. The Application and Problems of Tetrahedral Framework Nucleic Acids as a Drug Carrier in Biomedicine Fields -- Chapter 6. Research Progress on Antibacterial Application with Nucleic Acid and Nucleic Acid Materials -- Chapter 7. The Application of DNA Nanostructures in Vaccine Technology.-.
    Abstract: This book aims to comprehensively summarize the current research status of nanomaterials and cell biology. It highlights the biological effects and biomedical applications of nanomaterials for specific diseases, bone tissue engineering, and skeletal muscle regeneration. It also provides the details of the biomedical applications of nucleic acid nanomaterials in drug delivery carriers, antimicrobial therapy, vaccine, and neurodegenerative diseases. Therefore, this book renders the audience a better understanding of nanomaterials along with the diverse applications in the cell biology field from recent works to perspectives.
    Type of Medium: Online Resource
    Pages: IX, 219 p. 13 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811626661
    URL: https://doi.org/10.1007/978-981-16-2666-1
    DOI: 10.1007/978-981-16-2666-1
    DDC: 610.72
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  • 17
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    Online Resource
    Principles of Light Microscopy: From Basic to Advanced (2022)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Life sciences. ; Cytology. ; Spectrum analysis. ; Biomedical Research. ; Life Sciences. ; Cell Biology. ; Spectroscopy.
    Description / Table of Contents: Chapter 1. The physical principles of light propagation and light-matter interactions -- Chapter 2. Design, alignment and usage of infinity-corrected microscope -- Chapter 3. Epifluorescence Microscopy -- Chapter 4. Basic digital image design, processing, analysis, management, and presentation -- Chapter 5. Confocal Microscopy -- Chapter 6. Live-cell Imaging: A Balancing Act Between Speed, Sensitivity and Resolution -- Chapter 7. Structured Illumination Microscopy -- Chapter 8. Stimulated Emission Depletion Microscopy -- Chapter 9. Two-Photon Imaging -- Chapter 10. Modern microscopy image analysis: quantifying colocalization on a mobile device -- Chapter 11. Spinning Disk Microscopy -- Chapter 12. Light Sheet Fluorescence Microscopy -- Chapter 13. Localization microscopy: a review of the progress in methods and applications.
    Abstract: This textbook is an excellent guide to microscopy for students and scientists, who use microscopy as one of their primary research and analysis tool in the laboratory. The book covers key microscopy principles and explains the various techniques such as epifluorescence microscopy, confocal/live cell imaging, SIM/light sheet microscopy, and many more. Easy-to-understand protocols provide helpful guidance for practical implementation in various commercially available imaging systems. The reader is introduced to histology and further be guided through advanced image acquisition, classification and analysis. The book is written by experienced imaging specialists from the UK, other EU countries, the US and Asia, and is based on advanced training courses for master students and PhD students. Readers are not expected to be familiar with imaging and microscopy technologies, but are introduced to the subject step by step. This textbook is indented for biomedical and medical students, as well as scientists and postdocs who want to acquire a thorough knowledge of microscopy, or gain a comprehensive overview of modern microscopy techniques used in various research laboratories and imaging facilities. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 324 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031044779
    URL: https://doi.org/10.1007/978-3-031-04477-9
    DOI: 10.1007/978-3-031-04477-9
    DDC: 610.72
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  • 18
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    Online Resource
    Microscopy Techniques for Biomedical Education and Healthcare Practice : Principles in Light, Fluorescence, Super-Resolution and Digital Microscopy, and Medical Imaging (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical education. ; Materials Microscopy. ; Anatomy. ; Cytology. ; Education Data processing. ; Biomedical Research. ; Medical Education. ; Microscopy. ; Anatomy. ; Cell Biology. ; Computers and Education.
    Description / Table of Contents: Part I. Advances in Microscopy for Visualization, Education and Healthcare Practice -- Chapter 1. Visualizing the Invisible: Microscopy and How It Affects Our Understanding of Cells and Tissues -- Chapter 2. Morphometric Image Analysis and Its Applications in Biomedicine Using Different Microscopy Modes -- Chapter 3. The Shift in Power from Conventional to Digital and Virtual Microscopy -- Chapter 4. How Visualizations Have Revolutionized Taxonomy: From Macroscopic, to Microscopic, to Genetic -- Chapter 5. Bright New World: Principles of Fluorescence and Applications in Spectroscopy and Microscopy -- Chapter 6. An Introduction to Particle Tracking Techniques with Applications in Biomedical Research -- Chapter 7. An Exploration of the Practice of CT Modalities to Evaluate Anterior Cranial Deformities in Craniosynostosis -- Part II. Anatomical and Cell Biology Education -- Chapter 8. The Use of Biomedical Imaging in Visuospatial Teaching of Anatomy -- Chapter 9. Ultrasound Imaging for Musculoskeletal Research -- Chapter 10. Skill Acquisition in Histology Education.
    Abstract: This edited book has a strong focus on advances in microscopy that straddles research, medical education and clinical practice. These advances include the shift in power from conventional to digital microscopy. The first section of this book covers imaging techniques and morphometric image analysis with its applications in biomedicine using different microscopy modes. Chapters highlight the rich development of fluorescence methods and technologies; particle tracking techniques with applications in biomedical research and nanomedicine; the way in which visualizations have revolutionized taxonomy from gross anatomy to genetics; and the psychology of perception and how it affects our understanding of cells and tissues. The book’s first section concludes by exploring the use of CT modalities to evaluate anterior deformities in craniosynostosis. In the second section of the book, chapters on anatomical and cell biology education explore the history of anatomical models and their use in educational settings. This includes examples in 3D printing and functional human anatomical models that can be created using easily available resources and the use of biomedical imaging in visuospatial teaching of anatomy; the novel use of ultrasound in medical education and practice; and skill acquisition in histology education using a flowchart called a ‘decision tree’. This book will appeal to histologists, microscopists, cell biologists, clinicians and those involved in anatomical education and biomedical visualization, as well as students in those respective fields.
    Type of Medium: Online Resource
    Pages: XIV, 228 p. 107 illus., 94 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031368509
    Series Statement: Biomedical Visualization, 2
    URL: https://doi.org/10.1007/978-3-031-36850-9
    DOI: 10.1007/978-3-031-36850-9
    DDC: 610.72
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  • 19
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    Online Resource
    Cullin-RING Ligases and Protein Neddylation : Biology and Therapeutics (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Post-translational modification. ; Cytology. ; Biomedical Research. ; Post-translational Modifications. ; Cell Biology.
    Description / Table of Contents: Chapter 1 Introduction of Protein Ubiquitination and Cullin/RING Ubiquitin Ligases: introduce the protein ubiquitination system briefly; discuss the family of Cullin/RING Ubiquitin Ligases -- Chapter 2 Assembly and Regulation of CRL ubiquitin ligases: discuss the assembly process of CRL ubiquitin ligases by CAND1; elaborate the regulation of CRL ubiquitin ligases by neddylation -- Chapter 3 Protein structure of CRL and Neddylation complex -- Chapter 4 The roles of CRL ubiquitin ligases and neddylation in human diseases -- Chapter 5 The roles of CRL ubiquitin ligases in stem cell biology: Briefly introduce concept and potential application of stem cells; analyze a few example for CRL ubiquitin ligases to control stem cell biology -- Chapter 6 The biology of F-box proteins: introduce the history of SCF ubiquitin ligases; discuss the overall functions of F-box proteins (emphasize phospho-degron concept) -- Chapter 7 The roles of Fbxw7 in human diseases: discuss the roles of Fbw7 in cancer; elaborate the roles of Fbxw7 in other diseases -- Chapter 8 Mouse models of CRL1 components to study their biological function -- Chapter 9 Cullin2 and cancer: introduce Cullin2 ubiquitin ligases; discuss VHL ubiquitin ligase and its roles in cancer -- Chapter 10 Cullin3 and tumorigenesis: introduce Cullin3 ubiquitin ligases; discuss a few examples of Cullin3 ubiquitin ligases in control of tumorigenesis -- Chapter 11 Cullin4-DCAF proteins in tumorigenesis: Discovery of DCAF proteins; discuss a few examples of DCAF’s biological functions -- Chapter 12 Cullin4 ubiquitin ligases in DNA damage responses: Introduce Cullin4 ubiquitin ligases; discuss the roles of Cullin4 ubiquitin ligases in DNA damage responses -- Chapter 13 Coordinating the roles of Cullin5 ubiquitin ligases by SAG and UBE2F: introduce Cullin5 ubiquitin ligases; discuss how SGA and UBE2F mediates the functions of Cullin5 -- Chapter 14 Cullin5 in anti-virus infection: mechanism and drug target -- Chapter 15 The roles of Cul7 in cancer biology: introduce Cullin7 ubiquitin ligase7; discuss a few examples of Cullin7 ubiquitin ligases in cancer -- Chapter 16 Coordinating functions of p97 and CRL ubiquitin ligases in protein turnover: introduce the interactions between p97 and CRL ubiquitin ligases; discuss the coordinating roles between p97 and CRL ubiquitin ligases in protein turnover -- Chapter 17 Interaction between CRL ubiquitin ligases and COP9 Signalosome: introduce Cop9 signalosome; discuss how Cop9 signalosome regulates CRL ubiquitin ligases -- Chapter 18 Drug discovery effort to target Cullin-3 neddylation: discuss inhibitor of Cullin3 neddylation and its application -- Chapter 19 Targeting neddylation modification: Briefly introduce protein neddylation; discuss the roles of neddylation in cancer -- Chapter 20 Targeting CRL ubiquitin ligases: discuss current progress in targeting CRL ubiquitin ligases; discuss the application of CRL ubiquitin ligases in Protac drug development.
    Abstract: This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.
    Type of Medium: Online Resource
    Pages: VIII, 372 p. 119 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811510250
    Series Statement: Advances in Experimental Medicine and Biology, 1217
    URL: https://doi.org/10.1007/978-981-15-1025-0
    DOI: 10.1007/978-981-15-1025-0
    DDC: 610.72
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  • 20
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    The Extraordinary Biology of the Naked Mole-Rat (2021)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Biology Technique. ; Physiology. ; Evolution (Biology). ; Cytology. ; Vertebrates. ; Biomedical Research. ; Experimental Organisms. ; Animal Physiology. ; Evolutionary Biology. ; Cell Biology. ; Vertebrate Zoology.
    Description / Table of Contents: Dedication -- About the editors -- Preface (Jarvis JUM) -- Chapter 1. Social evolution in African mole-rats - a comparative overview (Faulkes CG & Bennett NC) -- Chapter 2. Social behavior in naked mole-rats: individual differences in phenotype and proximate mechanisms of mammalian eusociality (Holmes MM & Goldman BD) -- Chapter 3. Neuropeptidergic and neuroendocrine systems underlying eusociality and the concomitant social regulation of reproduction in naked mole-rats: a comparative approach (Coen CW, Bennett N, Holmes MM, & Faulkes CG) -- Chapter 4. Adult neural plasticity in naked mole-rats: implications of fossoriality, longevity and sociality on the brain’s capacity for change (Mooney SJ, Forger NG, & Holmes MM) -- Chapter 5. Sensory Systems of the African Naked Mole-Rat (Vice EN, Lagestee S, Browe BM, Deb D, Smith ESJ, Park TJ) -- Chapter 6. Hearing and vocalizations in the naked mole-rat (Barker AJ, Koch, U, Lewin GR, Pyott, SJ) -- Chapter 7. The somatosensory world of the African naked mole-rat (Lewin GR, Smith ESJ, Reznick J, Debus K, Barker A, and Park TJ) -- Chapter 8. The idiosyncratic physiological traits of the naked mole-rat; a resilient animal model of aging, longevity, and healthspan (Buffenstein R and Craft W) -- Chapter 9. African Naked Mole-Rats Demonstrate Extreme Tolerance to Hypoxia and Hypercapnia (Park TJ, Smith ESJ, Reznick J, Bennett NC, Applegate DT, Larson J, Lewin GR) -- Chapter 10. A sweet story of metabolic innovation in the naked mole-rat (Reznick J, Park TJ, and Lewin GR) -- Chapter 11. Insights into the molecular basis of genome stability and pristine proteostasis in naked mole-rats (Narayan V, McMahon M, O’Brien J, McAllister F and Buffenstein R) -- Chapter 12. The Unusual Immune System of the Naked Mole-Rat (Lin TD and Buffenstein R) -- Chapter 13 -- Induced Pluripotent Stem Cells from Cancer-Resistant Naked Mole-rats (Miura. K, Oiwa Y, and Kawamura Y) -- Chapter 14. Naked mole-rats: resistant to developing cancer or good at avoiding it? (Hadi F, Smith ESJ and Khaled WT) -- Chapter 15. Spontaneous Disease and Pathology of Naked Mole-rats (Delaney MA, Imai DM, Buffenstein R) -- Chapter 16. Managed Care of Naked Mole-rats (Smith M, and Buffenstein¬ R) -- Chapter 17. Some exciting future directions for work on naked mole-rats (Smith ESJ, ParkTJ, Holmes MM and Buffenstein R).
    Abstract: This volume focuses on the huge advances in the last 25 years on the use of this animal model for biomedical research (cancer, heart disease and neurodegeneration), fundamental neuroscience and basic subterranean biology. In 2013, Science magazine named the naked mole-rat as the Vertebrate of the Year. This was partly due to research carried out documenting its extreme longevity, negligible senescence, and prolonged maintenance of cancer free, good health well into old age as well as seminal work on mechanisms involved in these processes, pain and hypoxia resistance. In addition to this research focus on longevity and chronic diseases such as cancer and cardiovascular disease, the naked mole-rat has also made a substantial contribution to the fields of ecophysiology, neuroscience and behavior. With international contributions, this book provides a valuable text for zoological students, behavioral scientists and biomedical researchers.
    Type of Medium: Online Resource
    Pages: XIV, 445 p. 188 illus., 139 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030659431
    Series Statement: Advances in Experimental Medicine and Biology, 1319
    URL: https://doi.org/10.1007/978-3-030-65943-1
    DOI: 10.1007/978-3-030-65943-1
    DDC: 610.72
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  • 21
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    Breakthroughs in Space Life Science Research : From Apollo 16 to the ISS (2021)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Solar system. ; Aerospace engineering. ; Astronautics. ; Biomedical Research. ; Cell Biology. ; Space Physics. ; Aerospace Technology and Astronautics.
    Description / Table of Contents: Chapter 1. Introduction: Space Life Sciences – Basic Research and Applications under Extraordinary Conditions -- Chapter 2. A Long Way for Europe and Germany: From Apollo 16 to the International Space Station ISS -- Chapter 3. Success Stories: Incremental Progress and Scientific Breakthroughs in Life Science Research -- Chapter 4. Success Stories: Innovative Developments for Biomedical Diagnostics and Preventative Health Care -- Chapter 5. Space Life Sciences in the Exploration Era: An Outlook on Future Challenges and Opportunities.-.
    Abstract: This last volume of the SpringerBriefs in Space Life Sciences series is setup in 5 main parts. The 1st part shortly summarizes the history of life science research in space from the late 40s until today with focus on Europe and Germany, followed by a part on describing flight opportunities including the Space Shuttle/Spacelab system and the International Space Station ISS; in the 3rd part it focuses on extraordinary success stories of this constantly challenging research program and highlights some important key findings in space life science research. The book introduces in the 4th part innovative developments in non-invasive biomedical diagnostics and training methods for astronauts that emerge from this program and are of benefit for people on Earth especially in the aging society. Last but not least in its 5th part it closes with an outlook on the future of space life sciences in the upcoming era of space exploration. The book is intended for students and research scientists in the life sciences and biomedicine as well as for interested lay persons, who wish to get an overview of space life science research: its´ early days, current status and future directions.
    Type of Medium: Online Resource
    Pages: XVII, 155 p. 34 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030740221
    Series Statement: SpringerBriefs in Space Life Sciences,
    URL: https://doi.org/10.1007/978-3-030-74022-1
    DOI: 10.1007/978-3-030-74022-1
    DDC: 610.72
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  • 22
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    Online Resource
    Extracellular Vesicles in Cardiovascular and Metabolic Diseases (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Biological transport. ; Cell membranes. ; Biomedical Research. ; Translational Research. ; Cell Biology. ; Membrane Trafficking.
    Description / Table of Contents: Section I. Extraction Methods -- Chapter 1. Updated Methods of Extracellular Vesicles Isolation -- Section II. Extracellular Vesicles in Cardiovascular Disease -- Chapter 2. Extracellular Vesicles and Pathological Cardiac Hypertrophy -- Chapter 3. Extracellular Vesicles and Cardiac Aging -- Chapter 4. Extracellular Vesicles and Ischemic Cardiovascular Diseases -- Chapter 5. Extracellular Vesicles and Hypertension -- Chapter 6. Extracellular Vesicles and Coronary Artery Disease -- Chapter 7. Extracellular Vesicles and Vascular Inflammation -- Chapter 8. Extracellular Vesicles and Muscle Atrophy Treatment -- Section III. Extracellular Vesicles in Metabolic Diseases -- Chapter 9. Extracellular Vesicles and Fatty Liver -- Chapter 10. Extracellular Vesicles and Obesity -- Chapter 11. Extracellular Vesicles in Bone Remodeling and Osteoporosis -- Section IV. Therapeutic Implications -- Chapter 12. Diagnosis of Extracellular Vesicles in Cardiovascular and Metabolic Diseases -- Chapter 13. Therapeutics of Extracellular Vesicles in Cardiovascular and Metabolic Diseases -- Chapter 14. Gene Therapy of Extracellular Vesicles in Cardiovascular and Metabolic Diseases -- Section V. Future Prospects -- Chapter 15. Prospective Advances of Extracellular Vesicles Investigation in Cardiovascular and Metabolic Research -- Chapter 16. Effects of Exercise on Circulating Extracellular Vesicles in Cardiovascular and Metabolic Diseases -- Chapter 17. Extracellular Vesicle Release from Platelets and their Contributions to Thrombosis.
    Abstract: This book provides the latest research progress on Extracellular vesicles (EVs) in cardiovascular and metabolic diseases. EVs are small bilayer lipid membrane vesicles released by cells and function for intercellular communication. Increasing evidence has shown that EVs play crucial roles in cardiovascular and metabolic diseases, which seriously threaten human health worldwide. The book contains four sections: 1) Extraction Methods; 2) EVs in Cardiovascular Diseases; 3) EVs in Metabolic Diseases; and 4) Therapeutic Implications. This book is useful for biologists, cardiologists, cardiovascular surgeons, endocrinologists, internists, nurses, undergraduate and graduate students in medicine and cell biology, and others interested in cardiovascular and metabolic medicine.
    Type of Medium: Online Resource
    Pages: VIII, 275 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819914432
    Series Statement: Advances in Experimental Medicine and Biology, 1418
    URL: https://doi.org/10.1007/978-981-99-1443-2
    DOI: 10.1007/978-981-99-1443-2
    DDC: 610.72
    Language: English
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