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  • Books  (2,386)
  • bic Book Industry Communication::M Medicine  (1,213)
  • bic Book Industry Communication::J Society & social sciences::JN Education  (1,175)
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  • Books  (2,386)
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  • 1
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    Electrospun and Electrosprayed Formulations for Drug Delivery (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
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    Beverage Consumption Habits around the World: Association with Total Water and Energy Intakes (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 3
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    Messung von Experimentierfähigkeiten (2022)
    Logos Verlag Berlin | Logos Verlag Berlin
    Details
    Publication Date: 2023-02-02
    Description: Die vorliegende Arbeit beschäftigt sich mit der Validierung eines neuen Tests zur Messung von Experimentierfähigkeit in Large-Scale-Assessments. Die Testaufgaben erfordern die Planung, Durchführung und Auswertung typischer physikalischer Schülerexperimente der Sekundarstufe I. Anstelle von Realexperimenten werden interaktive Simulationen zum Aufbau von Experimenten und zur Durchführung von Messungen eingesetzt. Die Bearbeitung der Testaufgaben erfolgt vollständig am Computerbildschirm. Diesen Bearbeitungen werden in der Auswertung Punkte (Testwerte) zugewiesen. In der heute gültigen Vorstellung ist Validierung im Wesentlichen als ein theorie- und evidenzbasierter Argumentationsprozess aufzufassen. Nach der Nennung und Begründung notwendiger Validierungsschritte erfolgt eine schlüssige Validitätsargumentation. Ein Validierungsschritt kann z. B. darin bestehen, zu überprüfen, in wieweit zur erfolgreichen Bearbeitung der Testaufgaben Experimentierfähigkeiten eingesetzt werden. Die Ergebnisse der Validierungsschritte lassen sich wie folgt zusammenfassen: die Aufgabeninhalte und -anforderungen des Tests passen zum Physikunterricht der Sekundarstufe I; die Schüler denken und handeln bei der Bearbeitung der Testaufgaben experimentell; der verwendete Bewertungsmaßstab misst Experimentierfähigkeit; die erreichten Testwerte korrelieren mit den Testwerten, die bei inhaltlich identischen Realexperimenten erreicht werden. Zusammenfassend ist festzuhalten, dass der computerbasierte Test das Spektrum der in Large-Scale Assessments erfassbaren Experimentierfähigkeiten erweitert.
    Keywords: Education ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: German
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  • 4
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    Neuroimmune Interface in Health and Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 5
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    Vierte „Tagung der Fachdidaktik“ 2019 (2021)
    innsbruck university press
    Details
    Publication Date: 2021-02-10
    Description: This volume includes research contributions presented in May 2019 at the Leopold-Franzens University of Innsbruck and the Pädagogische Hochschule Tyrol as part of the "Fourth Conference of Subject Specific Education - Interdisciplinary Talks on Education for Sustainable Development". It documents the wide range of approaches, questions and methods with which education research is concerned at both institutions. The fourth conference served as an interdisciplinary platform and this volume contains the plenary lecture as well as seven presentations which show the variety of questions subjects specific education can deal with in the canon of education for sustainable development.; Der vorliegende Band umfasst Forschungsbeiträge, die im Rahmen der „Vierten Tagung der Fachdidaktik: Interdisziplinäre fachdidaktische Diskurse zur Bildung für nachhaltige Entwicklung“ an der Leopold-Franzens-Universität Innsbruck und der Pädagogischen Hochschule Tirol im Mai 2019 präsentiert wurden. Er dokumentiert die breite Fülle an Ansätzen, Fragestellungen und Methoden, mit der sich fachdidaktische Forschung am Hochschulstandort Innsbruck beschäftigt. Die vierte Tagung der Fachdidaktik diente dem interdisziplinären Diskurs und enthält neben der Verschriftlichung des einleitenden Plenarvortrages sieben Vor­träge, die beispielgebend aufzeigen, welche Beiträge die einzelnen Unterrichtsfächer zum Bildungskanon einer nachhaltigen Entwicklung leisten können.
    Keywords: Didactics ; Teaching ; School ; Didaktik ; Unterrichten ; Schule ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::Y Children's, Teenage & educational::YQ Educational material::YQS Educational: Sciences, general science
    Language: German
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  • 6
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    Pedagogía, afrocolombianidad y cine (2022)
    Universidad Santiago de Cali
    Details
    Publication Date: 2022-06-08
    Description: Published
    Description: La inspiración del presente libro surge de los procesos investigativos que cada autor presenta en diferentes escenarios: pedagógico, semiótico, hermenéutico, y enfoques sobre la alfabetización tecnológica: étnicos y normativos del cine. Es un producto de los métodos didácticos, del saber pedagógico que encuentra su espacio en el ámbito de lo educativo, sirviendo como una herramienta pedagógica para uso de maestros, estudiantes y comunidad en general, que se ocupa de un entramado gnoseológico complejo para indagar sobre el estudio de las ciencias sociales y humanas
    Keywords: Cine ; Enseñanza ; Cine en la educación ; Afrocolombianos ; Cultura popular ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: Spanish
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  • 7
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    Recursos Críticos: história da cooperação técnica Opas-Brasil em recursos humanos para a saúde (1975-1988) (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Um livro valioso, que analisa com clareza o papel fundamental dos recursos humanos para a saúde e o desenvolvimento, bem como o contexto e o impacto da reforma sanitária e a relação entre as iniciativas internacionais, nacionais e locais em prol da mudança dos serviços de saúde. Além de examinar os antecedentes e os principais atores da área de recursos humanos e explicar com detalhes as negociações que visavam transformar em prioridade nacional a formação de recursos humanos e a distribuição dos trabalhadores de saúde no território, Recursos Críticos está apoiado em uma sólida pesquisa bibliográfica, testemunhos fascinantes e análise original, que fazem da obra uma contribuição significativa no campo da memória da saúde pública e uma ferramenta indicativa de perspectivas de futuro para trabalhadores na área da saúde. É uma pesquisa histórica de grande qualidade, voltada para a análise da cooperação Opas-Brasil, e um incentivo à realização de novos estudos sobre as interfaces entre a atuação de agências internacionais e os interesses nacionais, partindo do conceito de arenas ou espaços de negociação.
    Keywords: R5-920 ; Brasil ; Recursos humanos em saúde ; Planos e programas de saúde ; Cooperação técnica ; Organização Pan-Americana da Saúde ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 8
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    Inhibiting PARP as a Strategic Target in Cancer (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 9
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    Holding still, together (2024)
    Radboud University Press
    Details
    Publication Date: 2024-03-29
    Description: This book provides unique insights into how health professionals and people with Parkinson’s disease shape care together. It shows both the courage and vulnerabilities of those who have to face this disease. It consists of photos of people with Parkinson’s disease and their care professionals, both of their interaction and portrayed individually, interwoven with fragments of their dialogue about meaningful care. This book is an integral part of a research project at Radboud university medical center into person-centred care. With it, we hope to contribute to a positive, hopeful vision of ever-improving Parkinson’s care.
    Keywords: Parkinson; Education; Perspective; Learning; Photography; Person-centred care ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology ; bic Book Industry Communication::A The arts::AJ Photography & photographs ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology ; thema EDItEUR::A The Arts::AJ Photography and photographs
    Language: English
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  • 10
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    International Perspectives on Health and Safety Among Dairy Workers Challenges, Solutions and the Future (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 11
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    From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders；celiac disease；gluten intolerance ; bic Book Industry Communication::M Medicine
    Language: English
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  • 12
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    Microglia in Health and Disease: A Unique Immune Cell Population (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 13
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    HLA-G-mediated Immune Tolerance: Past and New Outlooks (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
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  • 14
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    Technik – Kultur – Bildung (2023)
    Springer Nature | Springer VS
    Details
    Publication Date: 2023-11-17
    Description: In diesem Open-Access-Buch geht der Autor der Frage nach, warum Technik als wesentlicher Bestandteil der Kultur in der Bildung nur eine untergeordnete Bedeutung hat und begründet mit Hilfe technikphilosophischer Analysen einen Kulturreihenansatz für die Auswahl von Inhalten für den Technikunterricht. Aus dem Doppelauftrag von Schule, Persönlichkeitsbildung und Enkulturation wird zunächst ein Interaktionsmodell für Bildung und Erziehung abgeleitet. Das Problem der Inhaltsauswahl jeder Fachdidaktik wird mit einem Modell zur Verknüpfung von Allgemeiner Didaktik und Fachwissenschaften gelöst. Darin wird die Technikphilosophie als fehlende Bezugswissenschaft identifiziert, um Aussagen zum Wesen der Technik zu ermöglichen. Durch die Analyse technikphilosophischer Ansätze wird der Technikbegriff um eine ästhetische und eine Sinn- und Wertperspektive erweitert. Aus diesem Technikbegriff ergeben sich pädagogische Perspektiven für den Technikunterricht, die schließlich über einen Kulturreihenansatz zu einem Kern Technischer Allgemeinbildung führen. Durch den Kulturreihenansatz wird begründet umrissen, wie die kulturelle Bedeutung der Technik bildungswirksam werden kann.
    Keywords: Technik ; Technikphilosophie ; Erziehung ; Kultur ; Bildung ; Fachdidaktik ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: German
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  • 15
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    Schnittstelle Kunst - Vermittlung (2021)
    transcript Verlag
    Details
    Publication Date: 2024-03-29
    Description: Sieben Kunstschulen in Niedersachsen führten in den Jahren 2005 und 2006 Projekte entlang der Schnittstelle von Kunstproduktion und Bildungsarbeit durch. Dabei setzten sie sich mit Strategien der Gegenwartskunst auseinander, die auf Prozess, Kooperation und Intervention basieren. Das Buch bietet eine Reflexion und Theoretisierung dieser Projekterfahrungen und zeigt sowohl die Probleme als auch die Potenziale der Arbeit im Zwischenraum von Kunst und Bildung auf. Es möchte neue Impulse für die Kunstvermittlung geben, zu eigenen Experimenten und zum Weiterdenken anregen. Der partizipativ angelegte Forschungsprozess belegt, dass es möglich ist, die Komplexität der Prozesse in solchen Projekten zu analysieren und zu beschreiben und dabei die Beteiligung der Akteure und Akteurinnen als konstitutiv für den Erkenntnisprozess zu verstehen.
    Keywords: Kunst ; Bildung ; Vermittlung ; Kunstdidaktik ; Kulturmanagement ; Kunstmanagement ; Kulturelle Bildung ; Museumspädagogik ; Arts ; Education ; Cultural Management ; Art Management ; Cultural Education ; Museum Education ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: German
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  • 16
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    Aux heures suisses de l'école républicaine : Un siècle de transferts culturels et de déclinaisons pédagogiques dans l'espace franco-romand (2021)
    Demopolis
    Details
    Publication Date: 2023-12-20
    Description: Contrairement à une idée répandue, l'école de Jules Ferry n'est pas une invention made in France qui se serait élaborée en vase clos. Comme pour la plupart des espaces pédagogiques qui se consolident durant le XIXe siècle, les structures scolaires mises en place sous la IIIe République résultent d'un jeu d'absorptions et de réinterprétations de références étrangères. En décloisonnant ces espaces pour reformuler des connexions oubliées, cet ouvrage propose une relecture des relations (pédagogiques) franco-suisses. Dans ce sens, il répond à la nécessité de réévaluer l'histoire des nations occidentales afin d'en éclairer les racines étrangères et les dettes culturelles. Accepter que notre histoire soit aussi celle des autres constitue assurément un défi de taille pour l'ego-citoyen du XXIe siècle.
    Keywords: L7-991 ; pédagogie ; influence étrangère ; Suisse ; France ; XIXème siècle ; école laïque ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: French
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  • 17
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    Current Trends and Future Directions in Prosthetic and Implant Dentistry in the Digital Era (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
    Language: English
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  • 18
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    COVID-19: Current Status and Future Prospects (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Learning and Teaching in Adult Education (2021)
    Verlag Barbara Budrich
    Details
    Publication Date: 2022-04-28
    Description: Learning is a key issue in education. Being familiar with contemporary learning theory, therefore, is an essential prerequisite for education scholars and practitioners alike.
    Keywords: Adult Learning ; Adult Education ; Teaching techniques ; Behaviorism ; Cognition ; Didactic method ; Didacticism ; Lifeworld ; Phenomenography ; Pragmatism ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: English
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    Equity Policies in Global Higher Education (2022)
    Springer Nature | Palgrave Macmillan
    Details
    Publication Date: 2022-03-16
    Description: This book discusses and analyses global policies and practices aimed at promoting equity in higher education participation and attainment. Although the massification of higher education systems has facilitated the participation of students from deprived backgrounds, socioeconomic inequalities persist in access to the most prestigious institutions and programmes. Privileged students benefit from a number of advantages in the competition for selective and scarce places: access to information, lower aversion to debt, higher expectations, better previous schooling and higher academic achievement. The chapters present a critical analysis of equity policies in different countries – with or without affirmative action policies, within a context of neoliberal policies or within a social democratic model – and the reasons why they have failed to promote equity and fairness, preventing students from achieving their full educational potential. This is an open access book.
    Keywords: equity in higher education ; access to higher education ; participation in higher education ; attainment and retention ; higher education policy ; Open Access ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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    De Al-Ricotí al Rector Sabater: estudios históricos sobre la Universidad de Murcia y sus antecedentes (2021)
    Universidad Carlos III de Madrid. Figuerola Institute of Social Science History
    Details
    Publication Date: 2023-12-20
    Description: Recoge este libro, De Al-Ricotí al rector Sabater, complementarios acercamientos a la evolución de la enseñanza superior en Murcia, acercamientos que acaban, en conjunto, por ofrecer un friso más o menos integral de su desarrollo histórico, desde el foco islámico encontrado por los castellanos al someter el territorio en el siglo XIII, pasando por los colegios regulares y episcopales de la Baja Edad Media y la Edad Moderna, así como por las experiencias universitarias libres de la centuria decimonónica, hasta alcanzar la Universidad erigida en 1915 con su desenvolvimiento hoy ya centenario.
    Keywords: L7-991 ; Historia de las universidades ; Universidad de Murcia ; Universidades ; Historia ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: Spanish
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    Chapter 9 Between joyride and high-stakes examination (2021)
    Taylor & Francis | International Perspectives on Writing Curricula and Development | Routledge
    Details
    Publication Date: 2023-09-12
    Description: This chapter analyses how writing and writing development has been and currently is prescribed and enacted in the curriculum for Danish as a subject (L1) in Years 1–9. Highlighting historical points of impact for writing in curricula from the early–nineteenth century through frequent reforms in the twentieth and twenty-first centuries, we focus empirically on the 2014 ruling curricular document Common Standards and auxiliary documents framing writing assessment at the school-leaving exam, as well as empirical classroom studies. Analyses of steering documents indicate that there has been an unprecedented push towards outcome-based and competence-oriented writing curricula. Following Ivanič's Discourses of Writing (DoW) framework, process writing is found to be the most dominant discourse from Grades 1–7. The analysis of the enacted writing curriculum, which focuses on empirical studies from 2009 until now, reveals that the enacted curriculum is misaligned with the prescriptive curriculum and tends to position the student in ambiguous ways—from joyful writer to a writer tested in high-stakes exams. For discussion, we call for a more coherent writing curriculum. Methodologically, we argue that the DoW framework needs to be complemented with a Nordic Bildung tradition, which accentuates personal formation, and a multimodal framework informing the Danish curriculum.
    Keywords: writing studies, writing development, cross-national writing research, school writing, curricular analysis, curriculum, assessment tools, national education ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: English
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    Pathogenesis and Targeted Therapy of Epilepsy (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Cross Talk between Lymph Node Lymphatic Endothelial Cells and T Cells in Inflammation and Cancer (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Language: English
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    Lenguajeando mediación pedagógica (2022)
    Universidad Santiago de Cali
    Details
    Publication Date: 2024-03-29
    Description: Published
    Description: Si lo titulado anteriormente debiera ubicarse dentro de lo que la metodología tradicional considera como un ‘Resumen’, a continuación va entonces lo que en clave podría referirse sobre las ‘Palabras Clave’: brotes porque es lo que surge de las tierras, enacción quizá en el mejor sentido inglés de ‘to enact’, y rizomas en razón de los nacientes tejidos. Anotando al respecto que, si bien Deleuze (2005) acuñó el término en Francia en medio de sus referentes biológicos, es aquí en nuestra denominada Latinoamérica donde los rizomas los hemos ‘platanizado’. Porque aquí los hemos vivenciado y encontrado, hurgando con los dedos entre la tierra. A veces árida y en espera de las gotas de lluvia.
    Keywords: Mediación ; Realidad ; Comunidad ; Sustentable ; Afrocolombianos ; Identificación ; Recuperación ; Región Pacífico ; Valores Ancestrales ; Cognición ; Desarrollo humano ; Conocer ; Educarse ; Hermenéutica ; Sensorialidad ; Expresión ; Lenguajes ; Diversidad cultural ; Cartografía social ; Mapa parlante ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: Spanish
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    Espressioni dell'identità (2021)
    FrancoAngeli
    Details
    Publication Date: 2021-02-10
    Description: The book develops a reflection, shared by the authors, regarding some pedagogical phenomena which individuals and social groups have been involved in, thanks to theoretical and empirical analyses centred on case studies and articulated on two fronts. On the one hand, the topic is that of identity devices connected with specific educational processes, between being and having to be; on the other hand, there is the topic of the body as privileged observation point and region of identity. Different research experiences converge here in a shared path, aimed at an audience that is interested in the educational processes of today and the past, in its relationship with the controversial concept of identity.
    Keywords: identity ; education ; history of educational processes ; philosophy of education ; pedagogical devices ; body as region of identity ; bic Book Industry Communication::J Society & social sciences ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: Italian
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    Transmucosal Absorption Enhancers in the Drug Delivery Field (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
    Language: English
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    Researches in Adult Learning and Education: the European Dimension (2022)
    Firenze University Press
    Details
    Publication Date: 2022-06-02
    Description: The book represents several contributions that guide the readers in the comprehension of the paradigmatic shift from adult/lifelong education, to adult/lifelong learning. At the same time it presents the contexts where adults learn: the organized contexts, such as the institutions and services, and the informal contexts. The book is one of a series dedicated to adult learning and education developed under the auspices of ESRALE (European Studies and Research in Adult Learning and Education) an EU supported project. Its companion books are Maria Slowey (ed.) Comparative Adult Education and Learning. Authors and Texts and Vanna Boffo, Paolo Federighi, Ekkehard Nuissl, Empirical Research Methodology in Adult Learning and Education. Authors and Texts.
    Keywords: bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNA Philosophy & theory of education
    Language: English
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    Marxismo(s) e educação (2021)
    SciELO Books - Editora UEPG
    Details
    Publication Date: 2023-12-20
    Description: Este livro reúne reflexões de diferentes autores do campo educacional que se valem das contribuições de Karl Marx e da tradição marxista para problematizar a educação e o seu importante papel de mediação na formação de homens e mulheres capazes de compreender os antagonismos sociais imanentes à sociedade capitalista e de forjar possibilidades de sua superação.
    Keywords: L7-991 ; EDUCATION ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: Portuguese
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    Offene Kinder- und Jugendarbeit in Krisenzeiten aus Sicht von Jugendlichen (2023)
    Verlag Barbara Budrich
    Details
    Publication Date: 2024-03-29
    Description: Based on extensive data, including 800 hours of interview material, online questionnaires and group discussions, the second volume of results from the research transfer project "Child and Youth Work in Corona Times" at HAW Hamburg presents fascinating insights into the perspectives of young people between the ages of 13 and 25 on open child and youth work. The authors thus make a valuable contribution to the analysis of the significance of these institutions during the Corona era.
    Description: Kinder- und Jugendarbeit ist ein wichtiger gesellschaftlicher Ermöglichungs- und Unterstützungsort für junge Menschen. Basierend auf Gruppendiskussionen mit 87 Jugendlichen präsentiert der zweite Ergebnisband des Forschungstransferprojektes „Kinder- und Jugendarbeit in Corona-Zeiten“ der HAW Hamburg faszinierende Einblicke in die Perspektiven junger Menschen zwischen 13 und 25 Jahren auf Einrichtungen der Offenen Kinder- und Jugendarbeit – ein wertvoller Beitrag zur Analyse der Bedeutung dieser Orte für junge Menschen in Krisenzeiten.
    Keywords: child and youth work;Kinder- und Jugendarbeit;social work;Soziale Arbeit;Einrichtungen;institutions;Jugendliche;young people;practice work;Praxisarbeit;Fachkräfte;professionals;Teenager;teenagers ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JK Social services & welfare, criminology::JKS Social welfare & social services::JKSB Welfare & benefit systems::JKSB1 Child welfare ; bic Book Industry Communication::J Society & social sciences::JN Education::JNL Schools::JNLA Pre-school & kindergarten ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKS Social welfare and social services::JKSB Welfare and benefit systems::JKSB1 Child welfare and youth services ; thema EDItEUR::J Society and Social Sciences::JN Education::JNL Schools and pre-schools::JNLA Pre-school and kindergarten
    Language: German
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    Recent Progress of Nanomedicine and Targeted Drug Delivery for Cancer Treatment (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Language: English
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    Prognostic Factors for Pediatric Tumors (2024)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    One world, many knowledges (2023)
    African Minds
    Details
    Publication Date: 2024-03-29
    Description: Various forms of academic co-operation criss-cross the modern university system in a bewildering number of ways, from the open exchange of ideas and knowledge, to the sharing of research results, and frank discussions about research challenges. Embedded in these scholarly networks is the question of whether a global template for the management of both higher education and national research organisations is necessary, and if so, must institutions slavishly follow the high-flown language of the global knowledge society or risk falling behind in the ubiquitous university ranking system? Or are there alternatives that can achieve a better, more ethically inclined, world? Basing their observations on their own experiences, an interesting mix of seasoned scholars and new voices from southern Africa and the Nordic region offer critical perspectives on issues of inter- and cross-regional academic co-operation. Several of the chapters also touch on the evolution of the higher education sector in the two regions. An absorbing and intelligent study, this book will be invaluable for anyone interested in the strategies scholars are using to adapt to the interconnectedness of the modern world. It offers fresh insights into how academics are attempting to protect the spaces in which they can freely and openly debate the challenges they face, while aiming to transform higher education, and foster scholarly collaboration. The Southern African-Nordic Centre (SANORD) is a partnership of higher education institutions from Denmark, Finland, Iceland, Norway, Sweden, Botswana, Namibia, Malawi, South Africa, Zambia and Zimbabwe. SANORDs primary aim is to promote multilateral research co-operation on matters of importance to the development of both regions. Our activities are based on the values of democracy, equity, and mutually beneficial academic engagement.
    Keywords: higher educaton ; university ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNH Education: care & counselling of students ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy::JNFC Counselling and care of students ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education
    Language: English
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    Polymer Materials in Biomedical Application (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-03-21
    Description: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Keywords: hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
    Language: English
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    How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
    Language: English
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    Friedenspädagogik und Gewaltfreiheit (2021)
    Verlag Barbara Budrich
    Details
    Publication Date: 2024-03-29
    Description: Peace has to be learned again and again - and peace education has to deal with the conditions for this in a new way. In this volume, current lines of argumentation of non-violence and peace education are measured in the cpmtext of world society and thus innovative perspectives for peace education in the 21st century are presented.
    Keywords: Peace Education ; Nonviolence ; Global Learning ; Friedenserziehung ; Gewaltfreiheit ; Globales Lernen ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: German
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    Modelos de enseñanza comunitaria: un planteamiento desde la construcción del bien común (2023)
    Instituto de Investigación y Capacitación Profesional del Pacífico - IDICAP PACÍFICO | Desafíos y perspectivas de la educación (Tomo 2)
    Details
    Publication Date: 2024-03-29
    Description: Published
    Description: El concepto de bien común en los modelos de enseñanza implica un ámbito comunitario que se ha perdido en las instituciones de educación, derivado de la desvinculación del entorno, los actores y el contexto; sin embargo, las Escuelas Normales Rurales han sido resilientes al incorporar características del bien común. Esta investigación realiza una valoración desde los postulados de Jutta Bluert y Fuentes (2011) y Christian Felber (2012) para verificar la viabilidad de la incorporación del concepto de bien común a los modelos de enseñanza a través del fortalecimiento del sentido de pertenencia, la conciencia y perspectiva de la generación y uso de los recursos, la salvaguarda de las tradiciones y los saberes colectivos; así como el cuidado de la naturaleza poniendo en el centro de la toma de decisiones a la comunidad y su entorno. Con ello, fomentar modelos de enseñanza comunitarios como políticas públicas, implica incorporar las características de bien común.
    Keywords: Bien común ; educación ; enseñanza ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: Spanish
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    Avaliação e sociedade: a negociação como caminho (2021)
    SciELO Books - EDUFBA
    Details
    Publication Date: 2024-03-29
    Description: O livro é uma coletânea de artigos produzidos nos dois últimos anos pelo Grupo de Avaliação da FACED. São 11 artigos produzidos por 16 autores, imprimindo um caráter multidisciplinar e interdisciplinar ao conjunto da obra.
    Keywords: L7-991 ; EDUCATION ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: Portuguese
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    International and Comparative Studies in Adult and Continuing Education (2022)
    Firenze University Press
    Details
    Publication Date: 2022-06-02
    Description: This volume gives theoretical and practical insights in international and comparative research in the field of adult and continuing education. The 16 contributions of this volume give three perspectives on international and comparative adult education. The first perspective focuses on the question how internationalisation and comparative adult and continuing education can be taught. The second perspective gives insights into the results of comparative research that has been conducted throughout a two-week Winter School that took place in February 2019 in Würzburg. The third perspective complements the two perspectives with insights into international projects and practices in adult and continuing education. The authors of this volume are contributing to the transnational Winter School International and comparative studies in adult and continuing education in Würzburg, Germany since 2014.
    Keywords: comparative studies ; adult education ; continuing education ; good practices ; international adult education ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNA Philosophy & theory of education
    Language: English
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    La leçon de choses : Naissance de l’enseignement des sciences (2021)
    Presses universitaires du Septentrion
    Details
    Publication Date: 2024-03-29
    Description: La loi du 28 mars 1882, celle-même qui établit l’obligation d’instruction et la laïcité des enseignements, prévoit l’introduction dans les programmes obligatoires de l’école primaire des sciences physiques et naturelles. Quel sens peut avoir pour l’école républicaine cette nouveauté ? N’est-ce que l’aboutissement normal d’une scolarisation primaire organisée depuis Guizot, ou bien est-ce un indice significatif du "nouveau régime" que Jules Ferry annonçait pour l’école ? Rupture ou continuité ? L’analyse fait apparaître une tension remarquable entre la réalité des prescriptions (textes officiels, programmes, etc.), qui maintiennent les sciences dans la tradition modeste et utilitaire de l’école du peuple, et les représentations idéales d’un projet éducatif et culturel qui se veut inédit et qui tend à enrôler l’enseignement scientifique primaire au service de l’humanisme moral, rationaliste, laïque et scientiste qui a marqué la IIIe République naissante. L’analyse de la leçon de choses, méthode exemplaire et universellement préconisée d’un tel enseignement, témoigne de cette tension dialectique originale entre le rêve et la réalité de l’éducation scientifique primaire.
    Keywords: L7-991 ; enseignement ; étudiant ; science ; éducation ; professeur ; école ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: French
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    Ett skritt fram og ett tilbake (2021)
    Cappelen Damm Akademisk/NOASP (Nordic Open Access Scholarly Publishing)
    Details
    Publication Date: 2024-03-29
    Description: This book presents research results from the international comparative study TIMSS Advanced 2015, which investigates the competence of students taking the most advanced courses in mathematics and/or physics in the last year of upper secondary school. This is the third TIMSS Advanced study in which Norway has participated. As a result, we have good data for analyzing trends in competence from the nineties until 2015 for the students in question, which we may call experts in these subjects.
    Keywords: mathematics ; timss advanced 2015 ; physics ; upper secondary school ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: Miscellaneous languages
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    La formazione incorporata nei contesti lavorativi (2022)
    Firenze University Press
    Details
    Publication Date: 2022-06-02
    Description: Learning devices can be embedded into organizational contexts. Through them learning processes can be intentionally activated as to transform employees while working. Workplaces have their own learning potential due to their high level of structuring and regulation. Their learning potential transform organizational actors while they are in the productive actions. Identifying embedded learning processes helps in intercepting learning valencies of workplace experiences and observing learning actions that can lead to transformative processes. Results of related research activities are presented in the volume. They have been carried out in more than ten years of research implemented in three types of organisations: business, museum, prison. Research experiences are analysed by using a model of study that is based on the reconstruction of the learning processes as they are experienced by the actors considered. Moreover the model is based on the analysis of learning actions that are embedded into the productive and service provision processes. Factors and conditions are analysed as well through which organisations can act on employees transformation.
    Keywords: Embedded learning ; organizational learning ; workplace learning ; post-museum ; prison education ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNA Philosophy & theory of education
    Language: Italian
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    Rheumatic Diseases: Pathophysiology, Targeted Therapy, Focus on Vascular and Pulmonary Manifestations (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-05-06
    Description: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Keywords: systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Recent advances in γδ T cell biology: New ligands, new functions, and new translational perspectives (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
    Language: English
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    Traditional Medicines and Globalisation (2021)
    Maven Publishers
    Details
    Publication Date: 2022-04-28
    Description: The development of natural products requires the confluence of the modern techniques and integrated approaches in various fields of science and technology. Intention of this book is to highlight different aspects of globalization of traditional medicine with the focus on some crucial and contemporary issues on validation of natural products. Eminent scientists around the globe have contributed for this book on different issues of ethnopharmacology, traditional medicine and globalization. Given the importance on promotion and development of natural products, this book covers various aspects on revitalization of traditional medicines. The contributors have provided an insight into the modem aspects and future of traditional medicine inspired drug development, validation, safety related quality issues, sustainability and globalization. Bringing together expertise from academia and industry, this edited volume provides an overview of traditional medicine with wisdom and know-how in both innovation and commercialization, placing natural product research in a broader sense for readers. This edited volume contains 68 chapters emphasizing several thrust areas of ethnopharmacology and natural products. A wide diversity of chapters has been contributed by eminent personalities throughout the world including Dr. A. P. J. Abdul Kalam, Sri. Shekhar Dutt, Dr. Marco Leonti, Dr. G. A. Cordell, Dr. R. Verpoorte, Dr. P. J. Houghton, Dr. P. Pushpangadan, Dr. Y. K. Gupta, Dr. A.K.S. Rawat, Dr. S.K. Kulkarni, Dr. Colin W. Wright, Dr. S. C. Mandal, Dr. C. K. Katiyar, Dr. T. K. Mukherjee, Dr. S. Rajan, Dr. G. Schemda, Dr. P. K. Debnath, Dr. Bob Alkin, Dr. Elfin Y. Sukandar, Dr. N. Maity, Dr. A. K. Mitra, Dr. E. Hossain, Dr. H. Fukui, Dr. S.Bhadra, Dr. N. Neema, Dr. H. Mizuguchi, Dr. D. Chattopadhyay, Dr. T. Sen, Dr. Erdem Yesilada, Dr. S.K.Mitra, Dr. S.C. Bachar, Dr. S. Karmakar, Dr. G. B. J. Bailly, Dr. P. Haldar, Dr. Y. Oztruk, Dr. S. Pandit, and others. All representing the-state-of-the-art of the field, and thus would be interesting sources for information. This book will be of enormous help to the undergraduate and postgraduate students, researchers and academia and all others working in the area of Ethnopharmacology and natural product research. It will be an imperative addition to the libraries of technical and administrative personnel in the industries and Universities as a potential resource to update their knowledge.
    Keywords: Globalization ; traditional medicine ; bic Book Industry Communication::M Medicine
    Language: English
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    Power to Teach (2021)
    Taylor & Francis
    Details
    Publication Date: 2023-09-12
    Description: This book illustrates hitherto unexamined connections between the present state of teacher education in the UK and past models of practice. It locates contemporary debates within ongoing historical tensions over what constitutes a sound and proper start to a career in teaching. Questions as to the constituents of a professional training, the essential skills, knowledge and attitudes desired of an effective teacher, the most suitable locus of expertise, the relative roles of participants, and the balance of theory and practice lie at the heart of this book. The book reviews apprenticeship and teach-exemplar models of training, expert-novice relationships, model and demonstration teaching, school-based practice and the elaboration of core pedagogical principles in educational debate and research. These developments are assessed against recent initiatives in ITT, such as partnership models of ITT, school-based mentoring, advanced skills teaching, training schools, a standards-driven model of assessment for student teachers and models of effective teaching. Central to the book is the concept of the power to teach. By reclaiming this notion, the book offers challenging new perspectives on current policy and practice in teacher education today and adds to existing histories of teacher training of the past.
    Keywords: training ; college ; student ; teacher ; trainers ; institutions ; pupil ; system ; catherine ; dodd ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: English
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    Research Topics in Medicines and How Our Board Members Are Engaged in Them (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-06-21
    Description: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Keywords: Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Investing in Our Children (2023)
    RAND Corporation
    Details
    Publication Date: 2023-10-05
    Description: There is increasing evidence that the first few years after birth are particularly important in child development and present opportunities for enrichment but also vulnerabilities do to poverty and other social stressors. Elected officials have begun proposing potentially costly programs to intervene early in the lives of disadvantaged children. Have such interventions been demonstrated to yield substantial benefits? To what extent might they pay for themselves through lower welfare and criminal justice costs incurred by participating children as they grow into adults? This study synthesizes the results of a number of previous evaluations in an effort to answer those questions. Conclusions are that under carefully controlled conditions, early childhood interventions can yield substantial advantages to recipients in terms of emotional and cognitive development, education, economic well-being, and health. (The latter two benefits apply to the children's families as well.) If these interventions can be duplicated on a large scale, the costs of the programs could be exceeded by subsequent savings to the government. However, the more carefully the interventions are targeted to children most likely to benefit, the more likely it is that savings will exceed costs. Unfortunately, these conclusions rest on only a few methodologically sound studies. The authors argue for broader demonstrations accompanied by rigorous evaluations to resolve several important unknowns. These include the most efficient ways to design and target programs, the extent to which effectiveness is lost on scale-up, and the implications of welfare reform and other safety net changes.
    Keywords: Education ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: English
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    Proposition pour une rythmologie de la mobilité et des sociétés contemporaines (2021)
    Editions Alphil Presses universitaires suisses
    Details
    Publication Date: 2021-02-10
    Description: Il est 21 heures, Barbara et Maxime s’écroulent dans le canapé. Ils viennent de coucher le petit dernier. Il leur faut encore s’organiser pour la journée de demain. Maxime quittera la maison à l’aube pour éviter les embouteillages et Barbara suivra pour une présentation du travail d’une année à ses employeurs. Qui s’occupera des enfants ? Les esprits s’échauffent autour du même débat : il faut que l’un d’eux passe à 80% pour prendre soin des enfants et de la maison. Comme nombre de nos contemporains, Barbara et Maxime ressentent de plus en plus le manque de temps pour leur travail, leurs enfants et leur couple. Ils se sentent souvent prisonniers d’un rythme de vie toujours plus soutenu, soumis à des arbitrages permanents entre vie professionnelle, vie familiale et vie personnelle. Issu des recherches en cours sur l’accélération sociale et les rythmes de vie individuels ou collectifs, cet ouvrage milite pour un changement de regard sur les sociétés contemporaines en proposant une approche rythmique de la mobilité et des modes de vie. Cette proposition s’appuie sur l’analyse des comportements spatio-temporels et du rapport au temps chez des couples biactifs qui doivent concilier famille, travail et mobilité quotidienne. Les résultats mettent en perspective les importantes tensions liées à la gestion des temps quotidiens et suggèrent des formes de vulnérabilités temporelles qu’il s’agit de prendre en compte. Ils témoignent aussi des aptitudes développées par les couples pour gérer ces contraintes et des formes de mobilisation des ressources déployées dans la conduite de la vie quotidienne.
    Keywords: Rythmes de vie ; Mobilité ; Travailleurs frontaliers ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: French
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    Assessment in Mathematics Education: Large-Scale Assessment and Classroom Assessment (2021)
    Springer Nature
    Details
    Publication Date: 2024-03-29
    Description: Mathematics Education; Learning; Teaching
    Keywords: Mathematics Education ; Learning ; Teaching ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::P Mathematics and Science
    Language: English
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    Entscheidungsprozesse am inklusiven Übergang (2023)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: Based on a qualitative, longitudinal and constructivist research approach, the project at hand explores the decision-making process within the inclusive transition from secondary school I to further education from the perspectives of teenagers with disabilities and parents (with/without disabilities). The narratives of 5 families (3 teenagers with disabilities, 3 fathers, 5 mothers with/without disabilities) are of interest. The interviews were conducted three times (every year) during the transition-/decision-making process along the method of intensive interviewing (Charmaz 2014). The analysis of the qualitative data (32 interviews) was based on the coding process according to Charmaz (2014). Through data analysis three types of decision-making could be identified (giving up decision, forcing decision, taking over decision) as subforms of two higher-level decision-making mechanisms named make an independent decision and make a(n) (independent) decision with support. The expectation of an independent decision-making individual is central for teenagers with disabilities and their parents. Different types of “volition” are connected to the decision-making processes, depending on if the teenagers with disabilities make an independent decision (really want it), make a decision with support ((don’t) want it) or make a decision owing to given opinions (have to). Due to the longitudinal research design the educational trajectories of teenagers with disabilities are also reconstructed.
    Description: Ausgehend von einem qualitativ, längsschnittlich und konstruktivistischen Forschungsdesign untersucht die vorliegende Studie das Erleben von Entscheidungsprozessen am inklusiv verstandenen Übergang von Sekundarstufe I in weitere schulische Bildung aus Sicht von Jugendlichen mit Behinderung und Eltern (mit/ohne Behinderung). Im Mittelpunkt stehen die Erzählungen von 5 Familien (3 Jugendliche mit Behinderung, 3 Väter, 5 Mütter mit/ohne Behinderung), die im Übergangs-/Entscheidungsprozess drei Mal im Abstand von einem Jahr mittels intensiv interviewing (Charmaz 2014) befragt wurden. Zur Auswertung des qualitativen Datenmaterials (32 Interviews) wurde auf die Kodierschritte von Charmaz (2014) zurückgegriffen. Die Datenanalyse offenbart drei Varianten des Entscheidens (entscheiden abgeben, entscheiden forcieren, entscheiden müssen) als Ausdifferenzierungen der übergeordneten Entscheidungsformen selbstständig entscheiden und unterstützend (selbstständig) entscheiden. Zentral ist die Erwartung eines selbstständigen Entscheidungssubjekts, an der sich die Jugendlichen mit Behinderung und Eltern orientieren. Damit einher gehen unterschiedliche Varianten des Wollens, wenn Jugendliche mit Behinderung als Entscheidungssubjekte selbstständig (es wirklich wollen), mit Unterstützung (es (nicht) wollen) oder innerhalb vorselektierter Optionen (es müssen) eine Wahl treffen. Durch das längsschnittliche Forschungsdesign können zudem die Bildungsverläufe der Jugendlichen mit Behinderung nachgezeichnet werden.
    Keywords: Schulpädagogik; Sekundarstufe I, empirische Studie, Übergang, Entscheidungsprozesse, weiterführende Schule, Bildungsverlauf, Behinderung, Jugendliche, Heterogenität ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: German
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    Chapter 2 Practical gender in critical pedagogy (2021)
    Taylor & Francis | Intersectional Pedagogy | Routledge
    Details
    Publication Date: 2024-03-29
    Description: This chapter offers a theoretical and methodological framework for implementing feminist critical pedagogy in compulsory courses in gender studies. The method examined presents a gender analysis of daily objects by students as a means of dealing with resistance to gender studies and feminist theory, as well as creating a consciousness-changing experience for the participants.
    Keywords: Creative ; Education ; Gal ; Gender ; Harmat ; Intersectional ; Peace ; Pedagogy ; Practices ; Work ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: English
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    La relación médico-paciente (2021)
    Publicacions i Edicions de la Universitat de Barcelona
    Details
    Publication Date: 2023-12-21
    Description: La relación médico-paciente está sometida a varias presiones. La financiación de la asistencia sanitaria puede determinar tanto la percepción colectiva del acceso a los recursos sociales (prestaciones económicas, centros de atención especializada, ayudas a domicilio, entre otros) como la prescripción de medicamentos y de pruebas complementarias. Además de las prioridades del financiador o de los beneficiarios de los resultados económicos, las campañas publicitarias influyen también en el criterio del paciente, al que la industria farmacéutica halaga convenciéndolo de que posee conocimientos de medicina y de que es un consumidor con el poder de escoger, cuando en realidad decide porque tiene los medios económicos para pagar su elección. En este libro se analizan las razones que empujan a los profesionales de la sanidad hacia una parcialidad interesada, así como las consecuencias éticas que ello tiene sobre el individuo y sobre la eficiencia del sistema sanitario.
    Keywords: R5-920 ; RA1-1270 ; BJ1-1725 ; Relacions metge-pacient ; Medicina ; Dret ; bic Book Industry Communication::M Medicine
    Language: Spanish
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    Global health issues of aflatoxins in food and agriculture: Challenges and opportunities (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
    Language: English
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    Emerging Materials for Additive Manufacturing (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    Marine Compounds and Cancer (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
    Language: English
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    Personalized Medicine for Parkinson's Disease (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
    Language: English
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    Urological Cancer 2022 (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    Scuole in movimento (2021)
    FrancoAngeli
    Details
    Publication Date: 2021-02-10
    Keywords: pedagogy ; architecture ; design ; pedagogical research ; school design processes ; education ; bic Book Industry Communication::J Society & social sciences ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: Italian
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    Chapter La Pedagogia Civile per uno sviluppo territoriale sostenibile (2023)
    Firenze University Press
    Details
    Publication Date: 2024-03-29
    Description: Nowadays poverty can be defined as a construct that can no longer be ascribed to the material scarcity of resources but to the lack of all available relational, social and cultural resources, that are an expression of a “suffering” territory. This fragility testifies to a problem of educational sustainability that requires an exit from the emergency logic of “buffer interventions” by activating social, training and professional networks, capable of responding to the educational needs expressed by the territory. For this reason, in the epistemic framework of Civil and Digital-Civil Pedagogy, the need emerges for new professional profiles capable of being “managers” of integrated territorial development, educators-planners of territorial educational services with a view to social sustainability and the educational human transition.
    Keywords: Civil Pedagogy ; territoriality ; well-being ; social sustainability ; educational transition ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: Italian
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    Epigenetics of B Cells and Antibody Responses (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
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    Metodologías narrativas en educación (2021)
    Publicacions i Edicions de la Universitat de Barcelona
    Details
    Publication Date: 2024-03-29
    Description: La narración es una herramienta educativa de primer orden. Con el denominado «giro narrativo» en el ámbito de las ciencias sociales, el interés por sus diversas formas y contextos no ha dejado de aumentar, hasta el punto de generar una nueva disciplina: la narratología. Sin embargo, su repercusión tanto en el ámbito educativo de la escuela, como en la educación social y el trabajo social, no ha sido tan amplia. Este libro expone teorías pedagógicas, metodologías con ejemplos de su aplicación: desde las historias de vida y las autobiografías hasta los relatos digitales, en varios contextos sociales y etapas vitales (el aula, la prisión, la inmigración, la formación de profesionales, la vejez), y recoge aportaciones de autores italianos, sudamericanos y españoles, todos con una vasta experiencia en este campo.
    Keywords: L7-991 ; HM401-1281 ; Autobiografia ; Sociologia de l'educació ; Narració (Retòrica) ; Narrativa digital ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: Spanish
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    Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
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    The Governing-Evaluation-Knowledge Nexus (2021)
    Springer Nature
    Details
    Publication Date: 2021-02-10
    Description: This Open Access book analyses the interplay between governing, evaluation and knowledge with an empirical focus on Swedish higher education. It investigates the origins, logics, and mechanisms of evaluation and quality assurance reforms and their dynamic interactions with institutional, national and European policy contexts. The chapters report findings from extensive empirical studies that offer detailed insight into the work of governing in higher education, by giving voice to actors at various levels and positions including the ministry, national agency and University employees. Central themes include the influence of European policy, changing system designs, media relations and quality assurance enactments in University institutions. The book also explores the ways in which an emerging professional cadre, labelled qualocrats, enacts and mediates evaluation and quality assurance policy and practice. Taken together, the expanding evaluation machinery in Swedish higher education highlights the pivotal role of knowledge as a governing resource, and points to special features of evaluation as a particular form of practice that makes knowledge work for governing.
    Keywords: Education ; Higher education ; Assessment ; Educational policy ; Education and state ; Educational sociology ; School management and organization ; School administration ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education::JNKD Examinations & assessment ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education
    Language: English
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    Higher Education in Romania: Overcoming Challenges and Embracing Opportunities (2022)
    Springer Nature | Springer
    Details
    Publication Date: 2022-03-16
    Description: This open access book includes a series of relevant policy research articles, elaborared in the framework of the “Quality in higher education: internationalisation and databases to enhance the Romanian education system” project, implemented by the Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI), together with the Ministry of Education. The project aims to develop and implement systemic measures at tertiary education level, leading to an increased quality of the overall higher education system and universities better prepared for labour market requirements and international standards. The book focuses on areas of interest for Romanian higher education, such as systemic measures to improve access, participation and completion for (vulnerable) students, better promotion of the Romanian higher education to attract students, as well as instruments for a more efficient use of data at higher education level. Each article includes evidence-based policy proposals that could support new strategic initiatives in higher education, including new legislation. Additionally, the collection of articles tells a comprehensive story about the audacity of a higher education system which went through significant challenges to align itself with both European and international trends, as well as respond to national imperatives. Over the last three decades, since the fall of the Iron Curtain, Romanian higher education has undergone significant transformations, aiming to align itself to the latest developments and trends at European and international level. The National Law on Education no. 1/2011 has set the stage for a full implementation of the Bologna Process action lines, taking into account that Romania was already a part of the largest European intergovernmental process – currently the European Higher Education Area (EHEA) – as a founding member. However, since the adoption of this normative framework, the law suffered numerous amendments, making it challenging to observe and achieve coherence in its implementation. Furthermore, Romania is also currently redesigning the strategy for the alocation of European structural funds 2021-2027, based on two strategic documents - the new Education and Employment Operational Programme and the National Recovery and Resilience Plan which highlight the reform and investment priorities at a national level. At the same time, 2021 is a good time to analyze the level of implementation for the objectives and measures included in the National Strategy for Tertiary Education 2015-2020, the Europe 2020 Strategy, and the Bologna Process action lines in the 2010 – 2020 timeframe. Therefore, the present moment may be an important time to assess the impact of strategic documents and actions in the last decade and, possibly, to draft a new National Education Law, better adapted to current realities, starting from the recent initiative by the President of Romania – the Educated Romania strategic vision which was also politically assumed by the Romanian Government.
    Keywords: Romanian Higher Education ; Future Direction of European Higher Education ; Internationalization of Higher Education ; Digital Technology in Higher Education ; Educational Policy Romania ; European Policies Higher Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy
    Language: English
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    Saúde, trabalho e formação profissional (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Reúne textos de especialistas das áreas de Saúde e de Educação com longa, competente e comprometida atuação na luta por mudanças sociais, preocupados com um (con)viver humano mais solidário. A obra mostra ser possível a constituição de serviços de saúde com profissionais sensíveis e preparados para atuar em tempos de novas exigências técnicas e de capacitação profissional. Por instigar a (re)pensar o aperfeiçoamento técnico e ético do trabalho, com idéias e propostas originais e atuais, trata-se, certamente, de contribuição de relevância para aqueles que, direta ou indiretamente, encontram-se engajados na causa do Sistema Único de Saúde.
    Keywords: R5-920 ; Pessoal técnico de saúde-educação ; Ocupação em saúde ; educação profissional ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Immune responses to AAV vectors, from bench to bedside (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
    Language: English
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    Refiguring Prose Style (2023)
    University Press of Colorado | Utah State University Press
    Details
    Publication Date: 2024-03-29
    Description: For about two decades, say Johnson and Pace, the discussion of how to address prose style in teaching college writing has been stuck, with style standing in as a proxy for other stakes in the theory wars. The traditional argument is evidently still quite persuasive to some-that teaching style is mostly a matter of teaching generic conventions through repetition and practice. Such a position usually presumes the traditional view of composition as essentially a service course, one without content of its own. On the other side, the shortcomings of this argument have been much discussed-that it neglects invention, revision, context, meaning, even truth; that it is not congruent with research; that it ignores 100 years of scholarship establishing composition's intellectual territory beyond "service." The discussion is stuck there, and all sides have been giving it a rest in recent scholarship. Yet style remains of vital practical interest to the field, because everyone has to teach it one way or another. A consequence of the impasse is that a theory of style itself has not been well articulated. Johnson and Pace suggest that moving the field toward a better consensus will require establishing style as a clearer subject of inquiry. Accordingly, this collection takes up a comprehensive study of the subject. Part I explores the recent history of composition studies, the ways it has figured and all but effaced the whole question of prose style. Part II takes to heart Elbow's suggestion that composition and literature, particularly as conceptualized in the context of creative writing courses, have something to learn from each other. Part III sketches practical classroom procedures for heightening students' abilities to engage style, and part IV explores new theoretical frameworks for defining this vital and much neglected territory. The hope of the essays here-focusing as they do on historical, aesthetic, practical, and theoretical issues-is to awaken composition studies to the possibilities of style, and, in turn, to rejuvenate a great many classrooms.
    Keywords: Education ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs::JNSV Teaching of students with English as a second language (TESOL) ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNU Teaching of a specific subject
    Language: English
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    Content Embedded Literacy in the Workplace (2022)
    Firenze University Press
    Details
    Publication Date: 2022-06-02
    Description: The topic of embedded literacy, closely connected to embedded learning on one hand, and training in the workplace on the other, is a central theme for reflection on adult education in Europe and around the world. The Council of Europe indicates knowledge as a pivotal element for the economic and social development of the EU countries and the workplace is an important place for the learning and production of know-how and knowledge. The problem of achieving the competences needed for entering the current labour market concerns a large part of the adult population. And this is where embedded literacy comes in, a topic which the volume tries to deal with from a twofold viewpoint: through theoretical reflection outlining the theme against the development of the European labour market, and reflection on hands-on experiences resulting from a project financed by the European Community called CELiNE, Content Embedded Literacy Education for the New Economy, carried out between 2007-2009.
    Keywords: Pedagogia ; Workplace ; Adult Education ; CELiNE ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNA Philosophy & theory of education
    Language: English
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    Bildung im digitalen Wandel (2021)
    Waxmann Verlag
    Details
    Publication Date: 2024-03-29
    Description: Published
    Description: Für die Umsetzung von Konzepten zur digitalen Bildung spielt der Prozess der Organisationsentwicklung eine entscheidende Rolle. Organisationsentwicklung setzt in Bildungseinrichtungen an mehreren Ebenen an und zielt auf Veränderungen in den Bereichen technische Infrastruktur, strategische Planung, Management, Kompetenzförderung und Ausgestaltung neuer Lernumgebungen. Entsprechend stellt der Gesamtprozess der Organisationsentwicklung große Anforderungen an die Leitungen von Bildungseinrichtungen, die die Digitalisierung idealerweise als ihre Kernaufgabe betrachten, Strategieprozesse anstoßen, als Gemeinschaftsprojekt in der Einrichtung verankern und die Umsetzung einzelner Maßnahmen begleiten. Die verschiedenen Beiträge betrachten diese Veränderungsprozesse in den Sektoren Bildung in Kindheit, Jugend und Familie, allgemeinbildende Schule, Lehrkräfteausbildung, in der Berufsbildung sowie der Erwachsenen- und Weiterbildung und stellen – bei unterschiedlicher Schwerpunktsetzung – aktuelle Entwicklungen der Forschung in Form von Critical Reviews zusammen. Dieser Sammelband mit fünf Reviews zur Organisationsentwicklung und Digitalisierung sowie einer Darstellung und Diskussion der methodischen Vorgehensweise ist der zweite Teil einer mehrteiligen Reihe mit Reviews zur Digitalisierung in der Bildung, deren Anliegen es ist, aktuelles Forschungswissen zu synthetisieren und zu strukturieren.
    Keywords: Critical Reviews ; Bildungsforschung ; Digitalisierung ; digitale Medien; Lehrpersonen; Lehrerbildung; Schule; Berufsbildung; Erwachsenenbildung; Weiterbildung; Weiterbildungsmanagement; Reviewverfahren; frühe Bildung; Kita; digitale Medien im Unterricht; Professionalisierung; Lehramtsstudium; digital Leadership; Schullentwicklung; Schulleitung; Hochschulentwicklung ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNK Educational administration and organization
    Language: German
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    Marine Natural Products as Anticancer Agents 2.0 (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Die Umsetzung von Bildung für nachhaltige Entwicklung im Sachunterricht (2023)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2023-12-08
    Description: The central “epoch-typical key problems” (Klafki 1993) that school education should address include the global challenges of socially produced inequality within our societies as well as the careful and responsible use of resources, both now and in the future. In view of this, as well as rapid processes of social change and increasingly complex challenges, the innovative capacity of the school as an institution is gaining in importance, because it has the task of enabling children and young people to actively shape an ecologically sustainable, economically efficient and socially just environment, considering global aspects. The presented dissertation ties in with this educational mission in schools. Based on findings that indicate that, firstly, education for sustainable development (ESD) is not yet sufficiently structurally anchored in schools and teaching, especially in the primary school sector, and secondly, that teachers and their motivation are decisive in the transfer of innovations and the implementation of programmatic models of school education, the present work investigates the question of which biographical dispositions and motives are evident in primary school teachers, implementing ESD in subject “Sachunterricht”. Thus, the work lies at the intersection of biographical professionalization, sustainability and school implementation research. In the theoretical references, the discourse on sustainability and corresponding educational concepts as well as approaches of implementation, innovation, implementation research as well as (biographical) professionalization research are used. For the empirical study, problem-centered interviews with primary school teachers in Lower Saxony were conducted and evaluated using sequence analysis based on objective hermeneutics. The aim is to reconstruct different case-specific patterns of orientation and interpretation as well as motives in relation to the implementation of ESD and to investigate connections between biographical and social structures and the motives for implementing education for sustainable development in “Sachunterricht” among teachers.
    Description: Als zentrale „epochaltypische Schlüsselprobleme“ (Klafki 1993), denen sich schulische Bildung zuwenden sollte, können u.a. die globalen Herausforderungen der gesellschaftlich produzierten Ungleichheit innerhalb unserer Gesellschaften sowie der sowohl gegenwärtig als auch zukünftig schonende und verantwortungsvolle Umgang mit Ressourcen gelten. Angesichts dessen sowie rascher gesellschaftlicher Wandlungsprozesse und zunehmend komplexerer Herausforderungen gewinnt die Innovationsfähigkeit der Institution Schule an Bedeutung, denn ihr kommt die Aufgabe zu, Kinder und Jugendliche zur aktiven Gestaltung einer ökologisch tragfähigen, wirtschaftlich leistungsfähigen und sozial gerechten Umwelt unter Berücksichtigung globaler Aspekte zu befähigen. An diesen schulischen Bildungsauftrag knüpft die vorgelegte Dissertationsschrift an. Ausgehend von Befunden, die darauf verweisen, dass erstens insbesondere im Grundschulbereich Bildung für nachhaltige Entwicklung (BNE) in Schule und Unterricht noch nicht hinreichend strukturell verankert ist und zweitens Lehrkräfte und ihre Motivation entscheidend beim Transfer von Innovationen und der Implementierung programmatischer Leitbilder schulischer Bildung sind, wird in der vorliegenden Arbeit der Frage nachgegangen, welche biographischen Dispositionen und Motive sich bei Grundschullehrkräften zeigen, die BNE im Sachunterricht umsetzen. Damit liegt die Arbeit im Schnittfeld von biographischer Professionalisierungs-, Nachhaltigkeits- und schulischer Implementationsforschung. In den theoretischen Bezügen werden zunächst der Diskurs um Nachhaltigkeit und entsprechende Bildungskonzeptionen sowie ferner Ansätze der Implementations-, Innovations-, Umsetzungsforschung sowie der (biographischen) Professionalisierungsforschung herangezogen. Für die empirische Untersuchung wurden problemzentrierte Interviews mit Grundschullehrkräften in Niedersachsen geführt und sequenzanalytisch in Anlehnung an die Objektive Hermeneutik ausgewertet. Ziel ist es, unterschiedliche fallspezifische Orientierungs- und Deutungsmuster sowie Motivlagen in Bezug auf die Umsetzung von BNE zu rekonstruieren und Zusammenhänge zwischen biographischen und sozialen Strukturen und den Motiven zur Umsetzung von Bildung für nachhaltige Entwicklung im Sachunterricht bei Lehrer*innen zu untersuchen.
    Keywords: BNE; Nachhaltige Pädagogik; Sachunterricht; Lehrkräftebildung; Professionsforschung; Rekonstruktive Sozialforschung; Lehrerbildung; Lehrerinnenbildung; Professionalisierung; ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: German
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    Lernwerkstattarbeit als Prinzip (2023)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: The present work "Lernwerkstatt als Prinzip - Möglichkeiten für Lehre und Forschung" (Learning Workshop as Principle - Possibilities for Teaching and Research), as the third volume of the series "Lernen und Studieren in Lernwerkstätten" (Learning and Studying in Learning Workshops), takes up the question of the possibilities of the principle of learning workshop work as a productive moment of developments in higher education didactics. Currently, there are controversial efforts to place the education of future pedagogues and educational scientists in a closer practical and research context. In this context, learning workshops as higher education institutions play a central role. Despite diverse forms and foundations, university learning workshops are united by a fundamental understanding: learning workshop work as a principle. In the contributions to this volume, the authors explore the potential of learning workshops for teaching and research in the context of science.
    Description: Das vorliegende Werk „Lernwerkstatt als Prinzip – Möglichkeiten für Lehre und Forschung“ greift als dritter Band der Reihe „Lernen und Studieren in Lernwerkstätten“ die Frage nach den Möglichkeiten des Prinzips Lernwerkstattarbeit als produktivem Moment hochschuldidaktischer Entwicklungen auf. Aktuell existieren kontrovers diskutierte Bemühungen, die Ausbildung von angehenden PädagogInnen und ErziehungswissenschaftlerInnen in einen engeren Praxis- sowie Forschungszusammenhang zu stellen. Hierbei nehmen Lernwerkstätten als Hochschuleinrichtungen eine zentrale Rolle ein. Trotz diverser Formen und Grundlagen werden Hochschullernwerkstätten von einem grundlegenden Verständnis geeint: Lernwerkstattarbeit als Prinzip. In den Beiträgen dieses Bandes loten die AutorInnen das Potenzial von Lernwerkstattarbeit für Lehre und Forschung im Wissenschaftskontext facettenreich aus.
    Keywords: Hochschuldidaktik; Hochschullernwerkstatt; Lehrerbildung; Lernwerkstatt ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: German
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    Dokumentarische Schulforschung (2023)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: Documentary school research establishes a research direction in which the interrelationship of subject-related knowledge acquisition and methodological-methodological aspects is reflexively examined. This volume is the prelude to several anthologies that have been produced in theDFG-funded network ""Documentary School Research"" (NeDoS) and are dedicated to this interrelationship. Three subject areas of documentary school research are the focus of this first volume: School Development, School Culture and School as Organisation. Fundamental questions are raised and dealt with in conceptual contributions. The current research situation is systematically presented in study reviews for each of the three subject areas as well as for existing English-language studies. Current approaches and results of school research operating with the documentary method are also presented in empirical contributions. Finally, the anthology also shows gaps and desiderata in school research using the documentary method and encourages further work in this field of research.
    Description: Mit der Dokumentarischen Schulforschung wird eine Forschungsrichtung begründet, in der das Wechselverhältnis von gegenstandsbezogener Erkenntnisgewinnung und methodisch-methodologischen Aspekten reflexiv in den Blick genommen wird. Der vorliegende Band bildet den Auftakt mehrerer Sammelbände, die imDFG-geförderten Netzwerk „Dokumentarische Schulforschung“ (NeDoS) entstanden sind und sich diesem Wechselverhältnis widmen. Drei Gegenstandsfelder einer Dokumentarischen Schulforschung stehen im Mittelpunkt dieses ersten Bandes: Schulentwicklung, Schulkultur und Schule als Organisation. In konzeptionellen Beiträgen werden grundlegende Fragen aufgeworfen und bearbeitet. Zu jedem der drei Gegenstandsfelder sowie zu vorliegenden englischsprachigen Studien wird über Studienreviews die aktuelle Forschungslage systematisch dargestellt. Aktuelle Zugänge und Ergebnisse einer mit der Dokumentarischen Methode operierenden Schulforschung werden darüber hinaus in empirischen Beiträgen präsentiert. Der Sammelband zeigt abschließend auch Leerstellen und Desiderate einer mit der Dokumentarischen Methode operierenden Schulforschung und regt zur Fortsetzung der Arbeit in diesem Forschungsfeld an.
    Keywords: education ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: German
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    Mediación en Espacios Virtuales Inmersivos (2022)
    Universidad Santiago de Cali | Lenguajeando mediación pedagógica
    Details
    Publication Date: 2022-06-24
    Description: Getting to know us today has other nuances very different from yesteryear times; to know something or to know a anyplace somewhere we used to use books, stories, print paper versions or grandmother ́s stories to shape distant spaces, places or things that we did not fully understand, we came to assume many things; today technology does not open a door to the world instead it opens a great gate show even more things, more stories and culture that in a life-time we ́ve could had not know. The issues is how to mediate knowledge and new ways of communicating in a globalized world that points out to individuality, how to make that an advantage to improve it and endow it with a holistic and complex view for the harmony of living beings that inhabit this planet for now.
    Description: Published
    Description: Conocernos hoy tiene otros matices muy distintos a tiempos de antaño; para saber de algo o algún lugar recurríamos a libros, a relatos, a versiones impresas en papel o a los cuentos de la abuela para dar forma a espacios lejanos, a lugares o cosas que no comprendíamos del todo, llegábamos a suponer muchas cosas; hoy la tecnología no abre una puerta al mundo sino un gran portón a todas sus anchas para mostrar aún más cosas, más historias y culturas que en una vida no podríamos conocer. El tema es cómo mediar el conocimiento y las nuevas formas de comunicarnos en un mundo globalizado y que apunta a la individualidad, como hacer de eso un plus para mejorar y dotarlo de una visión holística y compleja para la armonía de los seres vivos que habitamos este planeta por ahora.
    Keywords: Holismo ; Inmersión ; Mediación ; Realidad ; Virtualidad ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: Spanish
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    CD4+ T cell differentiation in infection: amendments to the Th1/Th2 axiom (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Keywords: R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Student Misconceptions and Errors in Physics and Mathematics (2021)
    Springer Nature
    Details
    Publication Date: 2021-02-10
    Description: This open access report explores the nature and extent of students’ misconceptions and misunderstandings related to core concepts in physics and mathematics and physics across grades four, eight and 12. Twenty years of data from the IEA’s Trends in International Mathematics and Science Study (TIMSS) and TIMSS Advanced assessments are analyzed, specifically for five countries (Italy, Norway, Russian Federation, Slovenia, and the United States) who participated in all or almost all TIMSS and TIMSS Advanced assessments between 1995 and 2015. The report focuses on students’ understandings related to gravitational force in physics and linear equations in mathematics. It identifies some specific misconceptions, errors, and misunderstandings demonstrated by the TIMSS Advanced grade 12 students for these core concepts, and shows how these can be traced back to poor foundational development of these concepts in earlier grades. Patterns in misconceptions and misunderstandings are reported by grade, country, and gender. In addition, specific misconceptions and misunderstandings are tracked over time, using trend items administered in multiple assessment cycles. The study and associated methodology may enable education systems to help identify specific needs in the curriculum, improve inform instruction across grades and also raise possibilities for future TIMSS assessment design and reporting that may provide more diagnostic outcomes.
    Keywords: Education ; International education  ; Comparative education ; Assessment ; Science education ; Mathematics ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education::JNKD Examinations & assessment ; bic Book Industry Communication::J Society & social sciences::JN Education::JNU Teaching of a specific subject ; bic Book Industry Communication::P Mathematics & science::PB Mathematics ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: English
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    Framing in Sustainability Science (2021)
    Springer Nature
    Details
    Publication Date: 2021-02-10
    Description: This open access book offers both conceptual and empirical descriptions of how to “frame” sustainability challenges. It defines “framing” in the context of sustainability science as the process of identifying subjects, setting boundaries, and defining problems. The chapters are grouped into two sections: a conceptual section and a case section. The conceptual section introduces readers to theories and concepts that can be used to achieve multiple understandings of sustainability; in turn, the case section highlights different ways of comprehending sustainability for researchers, practitioners, and other stakeholders. The book offers diverse illustrations of what sustainability concepts entail, both conceptually and empirically, and will help readers become aware of the implicit framings in sustainability-related discourses. In the extant literature, sustainability challenges such as climate change, sustainable development, and rapid urbanization have largely been treated as “pre-set,” fixed topics, while possible solutions have been discussed intensively. In contrast, this book examines the framings applied to the sustainability challenges themselves, and illustrates the road that led us to the current sustainability discourse.
    Keywords: Environment ; Sustainable development ; Regional planning ; Urban planning ; Nature conservation ; Economic development—Environmental aspects ; Environmental education ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNK Conservation of the environment ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNU Sustainability ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RP Regional & area planning
    Language: English
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    Communicating Medicine (2021)
    Ledizioni
    Details
    Publication Date: 2023-12-21
    Description: This study investigates eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in such reference works as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole. A vast amount of reference works was produced for experts and non-experts alike: medical topics were common in social settings, in personal and communal letters, in specialised journals, in pamphlets and in magazines. All this unprecedented activity certainly contributed to the vernacularisation, and the dissemination of medicine in different kinds of works and different text types. The texts examined in the study are representative of their authors’ effort to expand medical knowledge and to define medicine as an independent science based on strict observation, as well as to establish intelligibility within and outside the disciplinary discourse community.
    Keywords: R5-920 ; english ; medicine ; language ; communication ; bic Book Industry Communication::M Medicine
    Language: English
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    Good Health, Quality Education, Sustainable Communities, Human Rights (2022)
    Firenze University Press
    Details
    Publication Date: 2022-06-02
    Description: The publication collects the contributions presented during the International Symposium of the Italian UNESCO Chairs (CONIUS) entitled Human Rights and Sustainable Development Goals 2030, which took place on 16 November 2018 at the University of Florence. The contributions of national and international experts address the Global Aims for Sustainable Development of the UNESCO including Sustainable Development Goals (SDGs) n. 3 Improvement of the ‘Global Health’, n. 4 ‘Quality Education’, n. 11 ‘Cities and Inclusive Human Sett lements’ and n. 16 ‘Peace and Justice’, using transdisciplinary and transnational perspectives and implemented through theoretical studies and good practices.
    Keywords: bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNA Philosophy & theory of education
    Language: English
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    Open and Distance Education in Asia, Africa and the Middle East (2021)
    Springer Nature
    Details
    Publication Date: 2024-03-29
    Description: This book is open access under a CC BY 4.0 license. This book describes the history, structure and institutions of open and distance education in six countries: China, India, Russia, Turkey, South Africa and South Korea. It describes how open and distance education is evolving in a digital age to reflect the needs and circumstances of the national higher education systems in these countries. It also explores the similarities and differences between how their open and distance higher education systems are managed and structured. This book is the second in a series, following Open and Distance Education in Australia, Europe and the Americas (Springer 2018). Both books compare and draw conclusions about the nature of open and distance education in the context of various national higher education systems. In a digital era characterized by the growing use of online, open and distance education, this book will prove particularly valuable for policy-makers and senior administrators who want to learn about establishing or expanding open and distance education services. In addition, it offers a valuable reference guide for researchers, academics and students interested in understanding the different approaches to open and distance education.
    Keywords: Education ; Learning ; Instruction ; Educational technology ; International education  ; Comparative education ; Higher education ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNT Teaching skills & techniques ; bic Book Industry Communication::J Society & social sciences::JN Education::JNV Educational equipment & technology, computer-aided learning (CAL) ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNT Teaching skills and techniques ; thema EDItEUR::J Society and Social Sciences::JN Education::JNV Educational equipment and technology, computer-aided learning (CAL)
    Language: English
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    Transitionen im Jugend- und jungen Erwachsenenalter (2021)
    Seismo
    Details
    Publication Date: 2024-03-21
    Description: Much like the first volume published in 2011, the second volume of this anthology series gathers a selection of analyses which are empirically based on the data of the Swiss panel study TREE (Transitions from Education to Employment). The contributions of this volume carry on the investigation of the critical transitions during youth and young adulthood, drawing on sociological, economic, psychological and pedagogical research questions and thus highlighting the analytic and pluri-disciplinary research potential of the TREE data. One of the topical foci is the longterm influence of social origin on education and labour market pathways, particularly with regard to access to higher education.
    Keywords: education ; youth ; transitions ; adulthood ; employment ; labour market ; high education ; Cannabis als Rauschmittel ; Deutschland ; Einwanderung ; Kulturelles Kapital ; PISA-Studien ; Schweiz ; Soziale Herkunft ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: German
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    Três ensaios de bioética (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Leitores interessados no desenvolvimento teórico da bioética e, ao mesmo tempo, em sua aplicação na solução de conflitos morais certamente encontrarão neste livro materiais de grande valor. Cada capítulo coloca a bioética em um contexto diferente: na clínica, na genômica e na biossegurança. No primeiro ensaio, discutem-se as possibilidades dessa ‘caixa de ferramentas’ chamada bioética para compreender e tentar resolver conflitos de interesses e valores no âmbito das relações entre profissionais e usuários dos serviços de saúde. No segundo, o autor aplica as ferramentas da bioética ao caso dos conflitos morais que envolvem a genômica, contemplando argumentos favoráveis e contrários às práticas da engenharia genética e contribuindo para o raciocínio crítico e sem preconceitos sobre o tema. Por fim, o terceiro capítulo trata da interface entre a bioética e a biossegurança, que têm preocupações comuns, como a questão dos riscos, mas abordagens distintas – enquanto a bioética se ocupa dos valores morais, a biossegurança lança mão de medidas técnicas, administrativas e legais.
    Keywords: R5-920 ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Extracellular Vesicles: Biology and Potentials in Cancer Therapeutics (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-02-01
    Description: Extracellular vesicles (EVs) are particles wrapped in a lipid bilayer membrane and are naturally released from cells. This kind of cargo vessel is a nanostructure that mainly transfers lipids, proteins, various nucleic acid fragments, and metabolic components to neighboring cells or distant parts of the body through the circulatory system. EVs are of great significance to the communication mechanism between cells. This book collects feature articles to enhance our understanding of the biological characteristics of EVs and their potential applications.
    Keywords: extracellular vesicle ; precision oncology ; cancer biomarker ; prostate cancer ; drug delivery ; extracellular vesicles ; lysosome ; nanocarriers ; ultrasound ; size exclusion chromatography ; differential ultracentrifugation ; head and neck squamous cell carcinoma (HNSCC) ; exosomes ; cancer ; biomarker ; diagnostic ; therapy ; liquid biopsy ; small extracellular vesicles (sEV) ; tumor-derived exosomes (TEX) ; melanoma cell-derived exosomes (MTEX) ; proteomics ; tumor microenvironment ; biomarkers ; ectosomes ; neoplasia ; microvesicles ; small extracellular vesicles ; isolation ; purification ; size-exclusion chromatography ; ultracentrifugation ; sucrose density cushion ; lymph node ; spleen ; solid tissue ; microvesicle ; exosome ; cancer therapeutic ; drug carrier ; flow cytometry ; immunophenotyping ; swarm detection ; tumor-associated macrophages ; macrophage polarization ; mannose receptor ; HIV-1 Nef ; glioblastoma ; microRNA ; immunoprecipitation ; CD44 ; human milk ; nutrient ; microbiota ; microRNAs ; nanocommunicator ; diagnostic biomarker ; drug delivery vehicle ; personalized cancer immunotherapy ; therapeutic agents ; cell-to-cell communication ; ionising radiation ; non-targeted effects ; signalling ; imaging flow cytometry ; biomarker reservoirs ; cancer diagnostics ; disease monitoring ; large EVs ; ovarian cancer cells ; ES-2 ; OAW-42 ; adipose tissue origin mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Lipid Signaling in T Cell Development and Function (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.
    Keywords: R5-920 ; RC581-607 ; eicosanoid ; Inositol ; diacylglyerol ; PI3K ; Vitamin D ; T cell ; SHIP ; Pten ; Adipokine ; Lipid ; bic Book Industry Communication::M Medicine
    Language: English
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    Questões sociocientíficas na prática docente: ideologia, autonomia e formação de professores (2021)
    SciELO Books - Editora UNESP
    Details
    Publication Date: 2024-03-29
    Description: Com desenvoltura e conhecimento teórico aprofundado, Leonardo Fabio Martinéz Pérez percorre questões ligadas ao ensino de Ciências a partir de uma perspectiva histórica e crítica do próprio conhecimento científico. Ao desenvolver suas ideias, o autor transcende o lugar comum sobre esse tema e apresenta, por meio das lentes da filosofia e da epistemologia, o ensino de Ciências de maneira reflexiva. No segundo momento, Pérez recorre à análise do discurso para avaliar diferentes cursos de licenciatura e mestrado e sua influência na formação crítica de professores e na autonomia docente. Um livro que demonstra as dificuldades, os sucessos, as contradições e os limites impostos pela lógica disciplinar ditada pelo currículo de Ciências e as implicações dessa limitação no desempenho do professor ao preparar e ministrar suas aulas.
    Keywords: L7-991 ; EDUCATION ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: Portuguese
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    Foundations of Paleoparasitology (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Unprecedented initiative in the world, the book compiles the available knowledge on the subject and presents the state-of-the-art in paleoparasitology – term coined about 30 years ago by Brazilian Fiocruz researcher Luiz Fernando Ferreira, pioneer in this science which is concerned with the study of parasites in the past. Multidisciplinary by essence, paleoparasitology gathers contributions from social scientists, biologists, historians, archaeologists, pharmacists, doctors and many other professionals, either in biomedical or humanities fields. With varied applications such as in evolutionary or migration studies, their results often depend on the association between laboratory findings and cultural remains. The book is divided into four parts - Parasites, Hosts, and Human Environment; Parasites Remains Preserved in Various Materials and Techniques in Microscopy and Molecular Diagnostics; Parasite Findings in Archeological Remains: a paleographic view; and Special Studies and Perspectives. Signed by authors from various countries such as Argentina, USA, Germany and France, the book has chapters devoted to the discoveries of paleoparasitology on all continents.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: English
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    Cultura e professionalità educative nella società complessa (2022)
    Firenze University Press
    Details
    Publication Date: 2022-06-02
    Description: The keynote of the recent history of the faculty of educational science of Florence University is change. This has emerged in response to the demands for education expressed by a new knowledge society, spawned by the processes of globalisation, and the social need to foster interculturalism and the dialogue between diversities. In this new dimension of change, education becomes the framework for preparation, but also for re-integrating and updating life itineraries that are swift and precarious, veined with insecurity and disillusionment. Even in the new approach, the scientific and cultural benchmark continues to be a consistent adherence to the secular, historic-pedagogic and educational tradition represented by the masters of the "Florence School". Since its creation in 1996, the new faculty has staked forcefully on the centrality of training in relation to the traditional focus on the professionalism of primary and secondary school teachers, and on the new extra-scholastic training issues: the educational professions; pedagogic care; the social education of adults; the technologies of education and instruction; the philosophic, sociological, psychological and anthropological dimension of education; the broad sphere of hardship and marginalisation and the different faces of diversity.
    Keywords: Pedagogia ; Formazione ; Educazione ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNA Philosophy & theory of education
    Language: Italian
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    Facebook e educação: publicar, curtir, compartilhar (2021)
    SciELO Books - EDUEPB
    Details
    Publication Date: 2024-03-29
    Description: A obra apresenta elementos capazes de instigar a reflexão sobre a mídia social Facebook nos mais diversos contextos e situações, envolvendo os usos que as pessoas fazem dessa mídia; os temas que surgem e como esses se configuram enquanto objeto de estudo num ambiente de diálogo; os potenciais sociotécni­cos e educacionais da rede, enquanto espaços de subjetivação, sociabilidade e diferença; bem como os usos do Facebook no ensino superior e na formação continuada de professores.
    Keywords: L7-991 ; EDUCATION ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: Portuguese
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    Advances in the Diagnosis and Treatment of Thyroid Carcinoma (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-10-25
    Description: This reprint is related to the latest research in the field of thyroid surgery, including molecular and imaging diagnosis, surgical treatment, and the treatment of recurrent disease and advanced thyroid carcinoma.
    Keywords: thyroid carcinoma ; prophylactic central lymph node dissection ; lymph node metastases ; RET ; medullary thyroid carcinoma ; clinical management ; variants of uncertain significance ; differentiated thyroid cancer ; papillary thyroid cancer ; minimal extrathyroidal extension ; radioactive iodine therapy ; prognosis ; TNM ; histology ; multifocality ; lymph node metastasis ; vascular invasion ; autoimmune thyroid diseases ; radioiodine refractory ; Lenvatinib ; 18F-FDG-PET/CT ; cost-benefit analysis ; economics ; medical ; thyroid neoplasms ; radiomics ; ultrasound ; magnetic resonance imaging ; computer tomography ; prediction ; classification ; angiogenic microenvironment ; prognostic factors ; antiangiogenic therapy ; therapeutic target ; tumor microenvironment ; tumor behavior ; proliferation pathways ; cell cycle control pathways ; angiogenesis process ; thyroid cancer ; Gal-3 expression ; NIFTP ; EFVPTC ; lymphocytic thyroiditis (LT) ; immunohistochemical (IHC) analysis ; molecular imaging ; theranostics ; companion diagnostics ; immunoPET ; anaplastic thyroid cancer ; poorly thyroid cancer ; genetic landscape ; genetically guided therapy ; fluorodeoxyglucose F18 (18F-FDG) ; positron emission tomography (PET) ; magnetic resonance imaging (MRI) ; recurrence ; neoplasm metastasis ; thyroid surgery ; hypoparathyroidism ; fluorescence-guided surgery ; near-infrared autofluorescence ; PRKAR1A ; PKA ; Carney complex ; cAMP ; bone metastasis ; metastasectomy ; stereotactic radiosurgery ; ultrasound imaging ; thyroid nodule ; fine-needle aspiration ; papillary thyroid carcinoma ; lobectomy ; operative extent ; CONUT score ; tyrosine kinase inhibitors ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    Análisis comparativo de la competencia digital en estudiantes de educación secundaria (2022)
    Instituto de Investigación y Capacitación Profesional del Pacífico - IDICAP PACÍFICO
    Details
    Publication Date: 2022-10-12
    Description: La competencia digital es una temática que el contexto de pandemia a nivel mundial ha movilizado diferentes aspectos tanto sociales, culturales, educativos, salud, trabajo entre otros. Por lo que las personas en general se han visto obligados a adaptarse bruscamente a estos cambios. En ese sentido, en el ámbito educativo tanto docentes como estudiantes, hasta padres de familia se han visto inmersos en los entornos virtuales, desarrollando la competencia digital empíricamente o en algunos casos con apoyo. Por ello, el estudio estuvo orientado a determinar las diferencias existentes en la competencia digital de los estudiantes del primer al tercer grado de secundaria de cuatro instituciones educativas públicas, durante el periodo 2022. Es un estudio de carácter cuantitativo por que se recurrió al uso de la estadística descriptiva para el análisis de datos, de naturaleza empírica, según su finalidad fue una investigación básica con diseño no experimental y transversal, y de nivel descriptivo comparativo. Se utilizó la técnica de la encuesta que fue remitida vía on line a través de un cuestionario con opciones múltiples para la respuesta de los 256 participantes de la muestra. Uno de los principales resultados evidencia que dos grupos son diferentes en su competencia digital, el nivel predominante es intermedio. Se concluye que la competencia digital se desarrolla en niveles diferentes en dos grupos de estudio, resaltando que dichos grupos también guardan una marcada diferencia social, cultural y contextual.
    Description: Published
    Keywords: Competencia digital ; estudiantes ; manejo de información ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: Spanish
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    Biomedical Insights that Inform the Diagnosis of ME/CFS (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
    Keywords: R5-920 ; RM1-950 ; fatigue syndrome ; n/a ; work rehabilitation ; tryptophan metabolism ; substrate inhibition ; myalgic encephalomyelitis ; 3-dioxygenase ; ME (Myalgic Encephalomyelitis) ; assessment ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; muscles ; hypoacetylation ; circadian rhythm ; immune system ; chronic ; CFS (Chronic Fatigue Syndrome) ; energy metabolism ; ME/CFS ; immunological ; cytokine ; bistability ; diagnosis ; biomarker ; symptoms ; kynurenine pathway ; inflammation and immunity ; metabolism ; neuro-inflammation ; pathology ; signaling ; exercise ; Epstein Barr virus ; methylhistidine ; hypothalamic–pituitary–adrenal axis ; potential biomarkers ; critical point ; inflammation ; histone deacetylation ; participatory research ; neurology ; neuroimmune ; activin ; mitochondria ; patient-driven questionnaire ; medical retirement ; machine learning ; prognosis ; gut microbiota ; post-exertional malaise ; chronic fatigue syndrome ; mathematical model ; reference intervals ; diagnostic biomarker ; indoleamine-2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Programming the HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.
    Keywords: R5-920 ; RC648-665 ; RC321-571 ; Q1-390 ; HPA axis ; Vulnerability ; resilience ; early life stress ; materna ; bic Book Industry Communication::M Medicine
    Language: English
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    The Challenges of COVID-19 with Obesity-Related Cancers (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-05-11
    Description: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research.
    Keywords: COVID-19 ; neutropenia ; G-CSF treatment ; respiratory failure ; colorectal neoplasms ; gastrointestinal neoplasms ; immune checkpoint inhibitors ; neoplasms ; oncogenic viruses ; oncolytic virotherapy ; post-acute COVID-19 syndrome ; reactive oxygen species ; tumor escape ; SARS-CoV-2 ; thyroid cancer ; differentiated thyroid cancer ; COVID-19 severity ; inflammation ; immunity ; oxidative stress ; obesity ; SARS-Cov-2 ; oncology ; cancer screening ; clinical trials ; melanoma ; management ; pandemic ; teledermatology ; diagnostic delay ; immunotherapy ; vaccination ; lymph adenopathy ; cancer ; nutraceuticals ; supplements ; colorectal ; meta-analysis ; gynecologic oncology ; malignancy ; blood cancer ; hematologic malignancy ; leukemia ; lymphoma ; multiple myeloma ; myelodysplasia ; breast cancer ; cancer care ; screening ; surgery ; psychological distress ; cancer therapies ; immunogenicity ; safety ; vaccine hesitancy ; tumor subtype ; mortality ; intensive care unit ; medico-administrative data ; France ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Sumář dobré praxe (2023)
    Masaryk University Press | Masaryk University
    Details
    Publication Date: 2024-03-29
    Description: Title in English: Summary of Best Practice : Experiences in Inclusive Education An inclusive school strives to involve all actors in the life of the school. Management, faculty, assistants and counselors, pupils, parents and carers are all seen as important partners in education and upbringing. The basis of this partnership is mutual trust and belief in a common goal – the development of the educational potential and personality of each student. The school, which manages to build a positive climate, thus provides a pleasant environment in which all actors feel good and are themselves interested in participating in the life of the school. The publication is based on the best practice of schools in the Czech Republic. We convey their experiences, the challenges they faced and the ways in which they dealt with them. The Summary contains interesting ideas, tips for specific activities and proven measures.
    Keywords: Inclusive education ; elementary school ; school climate ; best practice cooperation ; well-being ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: Czech
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    Student Politics in Africa (2021)
    African Minds
    Details
    Publication Date: 2024-03-29
    Description: The second volume of the African Higher Education Dynamics Series brings together the research of an international network of higher education scholars with interest in higher education and student politics in Africa. Most authors are early career academics who teach and conduct research in universities across the continent, and who came together for a research project and related workshops and a symposium on student representation in African higher education governance. The book includes theoretical chapters on student organising, student activism and representation; chapters on historical and current developments in student politics in Anglophone and Francophone Africa; and in-depth case studies on student representation and activism in a cross-section of universities and countries. The book provides a unique resource for academics, university leaders and student affairs professionals as well as student leaders and policy-makers in Africa and elsewhere.
    Keywords: higher education ; Africa ; student governance ; governance ; Amateur Athletic Union ; Democracy ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: English
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    Riskante Nähe (2023)
    Springer Nature | Springer VS
    Details
    Publication Date: 2023-11-17
    Description: Ausgangspunkt der Arbeit ist eine neue, mediale Thematisierung sexueller Gewalt durch pädagogische Fachkräfte seit 2010. Dieser wird zu Beginn der Arbeit als Gegenstand seine ambivalenten Folgen dargestellt. Zum einen entwickelte sich ein großes Potential für Prävention, Intervention und längst überfällige Aufarbeitung. Zum anderen kommt es zu einem gesellschaftlichen Generalverdacht gegen pädagogische Fachkräfte. Vor diesem Hintergrund stellt die Arbeit die Frage: Vor welchen Herausforderungen stehen pädagogische Fachkräfte der Heimerziehung angesichts des neuen, öffentlichen Diskurses über sexuelle Gewalt gegen Schutzbefohlene? Anhand von sechs Gruppendiskussionen mit Teams, aus der Heimerziehung, wird mittels der Dokumentarischen Methode rekonstruiert, dass die Fachkräfte sich im Zuge des öffentlichen Diskurses unter Generalverdacht gestellt fühlen. Empirisch kann gezeigt werden, dass das Thema sexuelle Gewalt durch diesen und fünf weitere Anlässe für die Fachkräfte relevant wird (Ausbildung, biografische Betroffenheit, institutionelle Bedingungen, Tatverdacht/Gewalttaten und kindliche Bedürfnisse nach Versorgung und Nähe). Der subjektiv wahrgenommene Generalverdacht geht für die Fachkräfte einher mit der Angst vor Repressalien gegen die eigene Person oder Kolleg*innen. Kindliche Bedürfnisse nach Nähe werden für die Fachkräfte vor dem Hintergrund zum Risiko. Gehen sie den Bedürfnissen fachlich angemessen nach, glauben sie Gefahr zu laufen, sexueller Gewalt bezichtigt zu werden. Sie stehen vor einem professionellen Dilemma und müssen den Schutz der eigenen Person gegen die Nähebedürfnisse der Kinder und Jugendlichen abwägen. Die Folge ist distanziert(ere)s und technokratisches Handeln, welches je nach konzeptioneller Perspektive unprofessionell und im Hinblick auf die Bedürfnisse der Kinder und Jugendlichen verletzend sein kann. Um der Herausforderung zu begegnen, haben die Fachkräfte Bewältigungsstrategien entwickelt. Diese sind davon abhängig, (1) ob die Fachkräfte sich vorstellen können, dass eine*r ihrer Kolleg*innen sexuelle Gewalt verübt, (2) inwieweit sich Fachkräfte für ein Nähebedürfnis der Kinder und Jugendlichen verantwortlich fühlen (familienanalog vs. nicht familienanalog) und (3) wie sich der Umgang der Organisation mit der medialen Thematisierung darstellt. Als ein weiterer Ergebnisstrang kann in der Arbeit gezeigt werden, dass sexuelle Gewalt durch eigene Kolleg*innen nicht, bzw. nur sehr schwer vorstellbar ist. Diese „Undenkbarkeit“ ist in die Sprache der Beforschten eingeschrieben. Die Arbeit zeigt, wie dieser fehlende Wahrnehmungshorizont das Handeln der Fachkräfte beeinflusst. Dies ist ein Open-Access-Buch.
    Keywords: sexuelle Gewalt in pädagogischen Institutionen ; Generalverdacht ; Heimerziehung ; Dokumentarische Methode ; pädagogische Nähe ; Denkunmöglichkeit sexueller Gewalt ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: German
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    Økokritiske dialoger (2024)
    Scandinavian University Press (Universitetsforlaget)
    Details
    Publication Date: 2024-03-15
    Description: Published
    Description: Dagens læreplaner legger stor vekt på det å utforske tekster, steder, faglige temaer og ulike typer miljø og materiale, og anerkjenner utforskningens potensial i kunnskapstilegnelse. For å være en dyktig lærer i dagens og fremtidens skole, er det dermed viktig å oppøve gode strategier og ha hensiktsmessige metodiske redskaper for å drive utforskende undervisning. Dialogisk undervisning er grunnleggende utforskende. Denne boken viser hvordan økokritiske dialoger, som kombinerer en dialogisk tilnærming med perspektiver fra økokritikk, kan være en måte å utforske og videreutvikle det tverrfaglige temaet bærekraftig utvikling på i lærerutdanningene. Kapitlene i boken eksemplifiserer hvordan man kan arbeide med og ta i bruk økokritiske dialoger innenfor ulike lærerutdanningsfag og i skolen. Målet er å gi lærerutdannere, lærerstudenter og lærere i skolen faglige eksempler på, og verktøy til å gjennomføre, dialogisk undervisning der samspillet mellom mennesker og natur står sentralt. Bokens bidragsytere er Nina Goga, Lykke Guanio-Uluru, Kristine Kleveland, Hege Emma Rimmereide, Marcus Axelsson, Rikke Frøyland, Sissel Høisæter, Lisa Källström, Elisabeth Alne Olsen, Kaisu Rättyä, Marianne Røskeland og Inger Marie Vik.
    Keywords: bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNU Sustainability ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: Norwegian
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    Educare oltre confine. Storie narrazioni intercultura (2021)
    FrancoAngeli
    Details
    Publication Date: 2024-03-29
    Description: The volume is based upon the pedagogical intercultural project "L'Aquila oltre i confini", a set of educational programs on the active and participatory citizenship, on the prevention and the overcoming of all forms of discrimination and intolerance. The path propose methodologies that can be contextualized within schools and universities and used for training of educational and social professionals.
    Description: Il volume prende le mosse dal progetto pedagogico-interculturale “L’Aquila oltre i confini”, che ha visto la partnership dell’Università dell’Aquila insieme all’associazione capofila Bibliobus, con Arci, Koinonia e il Coordinamento territoriale Ricostruire Insieme, tutte operanti nel capoluogo abruzzese. L’esperienza nasce dalla volontà di progettare e condividere un percorso di realizzazione di programmi di formazione sulla cittadinanza attiva e partecipata, oltre che sulla prevenzione e sul superamento di tutte le forme di discriminazione e di intolleranza, tramite l’utilizzo di metodologie che possano essere trasversalmente contestualizzate all’interno della formazione scolastica, di quella universitaria e della formazione delle professionalità educative e sociali in generale. L’approccio di ricerca-azione e l’asse Associazioni-Scuola-Università si ritrova nell’ossatura dell’intero volume che, ad una prima parte di orientamento teorico in cui ci si sofferma sugli elementi cardine del nostro discorso pedagogico (intercultura, integrazione, narrazione), fa seguire altre tre sezioni a carattere operativo-metodologico descritte da tutti gli attori protagonisti del progetto.
    Keywords: active citizenship ; pedagogy ; social inclusion ; italy ; study ; studio ; integration ; integrazione ; cittadinanza attiva ; l'aquila ; students ; interculturalità ; university ; università ; pedagogia ; italia ; inclusione sociale ; studenti ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: Italian
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