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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Translational Neuroscience of Speech and Language Disorders: State of the Art. -2. Translational Neuroscience of Aphasia and Adult Language Rehabilitation. -3. Treatment and intervention approaches for the improvement of language abilities in neurodegenerative diseases -- 4. Neural and Genetic Mechanisms of Dyslexia -- 5. The role of memory systems in neurodevelopmental disorders of language -- 6. Transcranial direct current stimulation (tDCS) and Language/Speech: Can patients benefit from a combined therapeutic approach? -- 7. Transcranial Magnetic Stimulation in Aphasia Rehabilitation -- 8. The Cerebellum: A Therapeutic Target in Treating Speech and Language Disorders -- 9. Navigated rTMS for Mapping the Language Network in Preoperative Settings: Current Status and Future Prospects -- 10. Presurgical Language fMRI in Epilepsy: An Introduction -- 11. Lesion-symptom mapping in speech and language disorders: a translational perspective.
    Abstract: This edited volume provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative conditions on speech and language. It brings together contributions from several leading experts in a markedly broad range of disciplines, including Speech and Language Therapy, Neuropsychology and Neurology, but also Neurosurgery, Neuroimaging and Neurostimulation, as well as Engineering and Genetics.
    Type of Medium: Online Resource
    Pages: XVII, 290 p. 18 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030356873
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 2
    Keywords: Medical genetics. ; Genetics. ; Biotechnology. ; Medical Genetics. ; Genetics and Genomics. ; Chemical Bioengineering.
    Description / Table of Contents: Section I: The physiology of the gene/environment interaction -- Nutrition -- Physical Exercise -- Circadian Rhythm -- Toxicants: Smoke, Alcohol and Heavy Metals -- Hormones -- Section II: Gene-Environment Interaction and Disease Susceptibility -- Obesity and Metabolic Syndromes -- Cancer -- Neurological and Psychiatric Disorders -- Asthma and allergic disorders -- Lamarck Versus Darwin: The Concept of Aquired Epigenetic Inheritance -- Section III: Genome/Epigenome -- Genetic Contribution to Epigenetic Inheritance -- The Controversial Role of DNA Methylation in Epigenetic Inheritance -- Small Non-Coding RNAs -- Chromatin Modifiers -- Soma-to-Germline Information Transfer: Questions and Promises.
    Abstract: The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy. This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.
    Type of Medium: Online Resource
    Pages: VIII, 266 p. 11 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030352134
    DDC: 616.042
    Language: English
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  • 3
    Keywords: Conservation biology. ; Ecology . ; Molecular ecology. ; Animal migration. ; Animal culture. ; Biodiversity. ; Biotic communities. ; Population biology. ; Conservation Biology. ; Molecular Ecology. ; Animal Migration. ; Animal Science. ; Biodiversity. ; Community and Population Ecology.
    Description / Table of Contents: (1) Introduction on different applications of molecular tools to answer novel questions in the field of population genetics/genomics of endangered mammals (Mike Bruford, School of Biosciences, Cardiff University, UK) -- (2) Climate change impact at the genetic level: patterns in the Couesi's rice rat Oryzomys couesi (Ella Vázquez Domínguez, Instituto de Ecología, UNAM, Mexico) -- (3) Use of molecular and demographic data to prioritize populations of black-tailed prairie dogs (Cynomys ludovicianus) from Chihuahua, Mexico for conservation (Luis Eguiarte Fruns, Instituto de Ecología, UNAM, Mexico) -- (4) Anthropogenic and Historic Movements of American Black Bears Shape Contemporary Population Structure (Emily Puckett, Division of Molecular Sciences, University of Missouri, USA) -- (5) How many ESUs are of conservation interest within some species of Neotropical carnivores (Felidae, Canidae, Ursidae, Mustelidae and Procyonidae)? : Individual mitocondrial genes versus mitogenomics (Manuel Ruiz García, Departamento de Biología, Pontificia Universidad Javeriana, Spain) -- (6) Phylogeographic footprint of armadillo colonization in North America (María Clara Arteaga, Departamento de Biología de la Conservación, Mexico) -- (7) Koala conservation in Queensland: a role for a living genome bank in genetic rescue? (Jenny Seddon, School of Veterinary Science, The University of Queensland, Australia) -- (8) Noninvasive genetics sheds light on the status, phylogeography, and evolution of the most elusive carnivores: The case of the snow leopard (Jan Janecka, Department of Biological Sciences, Duquesne University, USA) -- (9) Documenting genetic diversity in changing populations for management and conservation (Jennifer Leonard, Conservation and Evolutionary Genetics, Estación Biológica de Doñana, Spain) -- (10) Conservation genetic of gray brocket deer (Mazama gouazoubira) in the southern of the distribution range (Susana González, Departamento de Biodiversidad y Genética, Universidad de Uruguay) -- (11) Noninvasive Genetic Monitoring of the Elusive European Wildcat as a Tool for Science-Based Wildlife Conservation (Katharina Steyer, Seckenberg Research Institute, Germany) -- (12) Conservation genetics in bats: current progress and future prospects (Serena Dool, University of Greifswald, Germany) -- (13) From dung to demography: Using noninvasive methods to study elephants inside and outside protected areas (Lori Eggert, Division of Biological Sciences, University of Missouri, USA) -- (14) Effect of the habitat connectivity in the genetic variability of the Volcano rabbit (Romerolagus diazi) (Jorge Ortega/Leslie Montes/José Antonio Guerrero, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional) -- (15) Different immune system diversity for city life: comparing major histocompatiblity complex alleles in San Joaquin kit fox (Vulpes macrotis mutica) (Jesus Maldonado/Tammy R Wilbert, Masoumeh Sikaroodi, Brian Cypher, Christine Van Horn Job, Katherine Ralls, and Patrick M. Gillevet, Center for Conservation Genomics, Smithsonian Institue, Washington, DC, USA) -- (16) Conclusion: current state and future prospects of conservation genomics in mammals (Jorge Ortega, Jesus Maldonado).
    Abstract: This book focuses on the use of molecular tools to study small populations of rare and endangered mammals, and presents case studies that apply an evolutionary framework to address innovative questions in the emerging field of mammalian conservation genomics using a highly diverse set of novel molecular tools. Novel and more precise molecular technologies now allow experts in the field of mammology to interpret data in a more contextual and empirical fashion and to better describe the evolutionary and ecological processes that are responsible for the patterns they observe. The book also demonstrates how recent advances in genetic/genomic technologies have been applied to assess the impact of environmental/anthropogenic changes on the health of small populations of mammals. It examines a range of issues in the field of mammalian conservation genomics, such as the role that the genetic diversity of the immune system plays in disease protection and local adaptation; the use of noninvasive techniques and genomic banks as a resource for monitoring and restoring populations; the structuring of population by physical barriers; and genetic diversity. Further, by integrating research from a variety of areas – including population genetics, molecular ecology, systematics, and evolutionary and conservation biology – it enables readers to gain a deeper understanding of the conservation biology of mammals that are at increasing risk of extinction at local, regional and global scales. As such, it offers a unique resource for a broad readership interested in the conservation biology of mammals and conservation management strategies to better preserve biodiversity.
    Type of Medium: Online Resource
    Pages: VII, 378 p. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030333348
    DDC: 333.9516
    Language: English
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  • 4
    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Challenge and Promise: A Snap-Shot on the Molecular Biology of Notch Signaling -- Overview of Basic Mechanisms of Notch Signaling in Development and Disease -- Ligand-induced cis-inhibition of Notch signaling: the role of an extracellular region of Serrate -- Phosphorylation and proteolytic cleavage of Notch in canonical and non-canonical Notch signaling -- Maheshvara a conserved RNA helicase regulates Notch signaling in Drosophila melanogaster -- Molecular Regulation of Notch Signaling by Gremlin -- Regulation of Notch Signaling in Drosophila melanogaster: the role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex -- Interaction of Long Non-Coding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss -- Insulin–dependent non-canonical activation of Notch in Drosophila: a story of Notch-induced muscle stem cells proliferation -- Molecular mechanisms of Notch signaling in lymphoid cell lineages development: NF-κB and beyond -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
    Type of Medium: Online Resource
    Pages: XIII, 172 p. 32 illus., 31 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030364229
    Series Statement: Advances in Experimental Medicine and Biology, 1227
    DDC: 571.978
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Invertebrates. ; Biotechnology. ; Biomaterials. ; Invertebrate Zoology. ; Biotechnology. ; Biomaterials.
    Description / Table of Contents: 1. Polyphenols and flavonoids from honey: Biological applications -- 2. Chemistry and application of lac and its by-products -- 3. Silk: an amazing biomaterial for future medication -- 4. Insect Chitin and Chitosan: Structure, Properties, Production and Implementation Prospective -- 5. Recent advances in the arthropod natural product chemistry -- 6. Silkworm: A Unique Creature for Natural Products -- 7. Present and future prospects on nutritious feeding using insects -- 8. Insect Pheromones and its applications in management of pest population -- 9. Non-Protein chemical compounds from Lepidopteran insect cocoons. .
    Abstract: This book reviews the latest research on bioproducts from various economically important insects, such as silkworms, honey bees, lac and drosophila, and termites, and discusses their general, biomedical and industrial applications in detail. It includes chapters focusing on insects as a food source, probiotics, silk-based biomaterials, insect pheromones, insects as biomedicine source, pupa oil chemistry, non-protein compounds from Lepidopteran insects, insect chitin and chitosan, polyphenols and flavonoids. Model insects like Bombyx mori or bees were domesticated in Asian countries thousands of years ago. Over time, natural products from these animals became industrialized and today they attracting increasing attention thanks to their sustainability and their manifold applications in agriculture and biomedicine. The book is intended for entomologists, material scientists, natural product researchers and biotechnologists. .
    Type of Medium: Online Resource
    Pages: X, 156 p. 44 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030366100
    DDC: 592
    Language: English
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  • 6
    Keywords: Agriculture. ; Agriculture Economic aspects. ; Power resources. ; Food science. ; Sustainability. ; Agriculture. ; Agricultural Economics. ; Natural Resource and Energy Economics. ; Food Science. ; Sustainability.
    Description / Table of Contents: Chapter 1. Food systems in Sri Lanka: components, evolution, challenges and opportunities -- Chapter 2. Nutrition transition in Sri Lanka: a meta-analysis of the nutrition profile -- Chapter 3. Cascaded tank-village system: present status and prospects -- Chapter 4. Soil survey, classification and mapping in Sri Lanka – past, present and future -- Chapter 5. Milestones in the history of rice improvement in Sri Lanka -- Chapter 6. Vegetable breeding in Sri Lanka in retrospect -- Chapter 7. Genetic improvement for sustainability of coconut production: the Sri Lankan experience -- Chapter 8. Breaking the mould: pave the way for future cereals -- Chapter 9. Recent developments in vegetable production technologies in Sri Lanka -- Chapter 10. Input intensification in food crops production and food security -- Chapter 11. A cross section of century-long experiences in entomological research in crop sectors: directions for future research -- Chapter 12. Animal feed production in Sri Lanka: past present and future -- Chapter 13. Livestock and poultry to assure sustainability in the food system -- Chapter 14. Fisheries sector contribution for sustainable food system: past, present and future -- Chapter 15. Evolution of agricultural extension system in Sri Lanka -- Chapter 16. Performance and potential of agricultural insurance: global and Sri Lankan perspectives -- Chapter 17. Agricultural research for sustainable food systems – recommendations with special reference to Sri Lanka.
    Abstract: A food system comprises the entire range of actors and interlinked activities related to food production, processing, distribution, marketing and trade, preparation, consumption, and disposal. When a food system operates without compromising the needs of future generations, it is considered to be a “Sustainable Food System.” The present-day food systems in Sri Lanka are diverse, and the natural and physical environment, infrastructure, institutions, society and culture, and policies and regulations within which the food systems operate, as well as the technologies employed, have shaped their outcomes. Agricultural research is a key factor in terms of innovation and technological advances. Innovation has been the main driver of food systems’ transformation over the past few decades and will be critical to addressing the needs of a rapidly growing population in a context of climate change and scarcity of natural resources. In addition, agricultural research must help meet the rising demand for food at affordable prices. Comprising 17 chapters written by specialist(s) in their respective subject-areas, this Contributed Volume on “Agricultural Research for Sustainable Food Systems in Sri Lanka: A Historical Perspective” shares the scientific knowledge accumulated by the National Agricultural Research System of Sri Lanka, including universities, and offers recommendations on how to make food systems more sustainable in order to address the current needs of Sri Lankan society. It presents perspectives on four key thematic areas, namely: (i) Crop and animal production, management, and improvement, (ii) Agro-product processing technologies, (iii) Natural resource management, and (iv) Socio-economic development and agri-business management.
    Type of Medium: Online Resource
    Pages: XIX, 394 p. 63 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811521522
    DDC: 630
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Anatomy. ; Internal medicine. ; Cytology. ; Biochemistry. ; Neuroscience. ; Anatomy. ; Internal Medicine. ; Cell Biology. ; Biochemistry.
    Description / Table of Contents: Neurosecretion: A Historical Overview -- Neurosecretion: Hypothalamic Somata versus Neurohypophysial Terminals -- Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus -- Somato-Dendritic Secretion of Neuropeptides -- Neurosecretory Vesicles: Structure, Distribution, Release and Breakdown -- Molecular Controls on Regulated Neurotransmitter and Neurohormone Secretion -- Secretory Astrocytes -- Action Potential-Induced Ca2+ Influx for Both Acute and Sustained Insulin Secretion in Pancreatic Beta Cells -- Plasticity in the Morphology of Lactotrophs and Folliculo-Stellate Cells and Prolactin Secretion -- Neuroendocrine and Metabolic Regulation of Plasma Growth Hormone Secretory Profiles -- Role of the TWIK-Related Potassium (TREK)-1 Channels in the Regulation of Adrenocorticotropic Hormone (ACTH) Secretion from Pituitary Corticotropes -- How Do Bacterial Neurotoxins Affect Neurosecretion? -- Secretory Mechanisms in Paramecium.
    Abstract: How do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: state‐dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted. While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows. This is the eighth volume in the Masterclass in Neuroendocrinology series* - now a co-publication between Springer Nature and the INF (International Neuroendocrine Federation). *Volumes 1-7 published by Wiley.
    Type of Medium: Online Resource
    Pages: XIII, 307 p. 65 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030229894
    Series Statement: Masterclass in Neuroendocrinology, 8
    DDC: 612.8
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Microbial genetics. ; Evolution (Biology). ; Population genetics. ; Microbial ecology. ; Medical genetics. ; Genetics. ; Microbial Genetics. ; Evolutionary Biology. ; Population Genetics. ; Microbial Ecology. ; Medical Genetics. ; Genetics and Genomics.
    Description / Table of Contents: Part 1: Genomic diversity and the pan-genome concept -- Chapter 1: The pan-genome: a data-drivendiscovery in biology -- Chapter 2: The prokaryotic species concept and challenges -- Chapter 3: Bacterial guide on how to design a diversified gene portfolio -- Chapter 4: A review of pan-genome tools and recent studies -- Part 2: Evolutionary biology of pan-genomes -- Chapter 5: Structure and dynamics of bacterial populations: pan-genome ecology -- Chapter 6: Bacterial microevolution and the pan-genome -- Chapter 7: Pan-genomes and selection: the public goods hypothesis -- Chapter 8: A pan-genomic perspective on the emergence, maintenance and predictability of antibiotic resistance -- Part 3: Pan-genomics: an open, evolving discipline -- Chapter 9: Metapangenome: at the crossroad of pangenomics and metagenomics -- Chapter 10: Pan-genome flux balance analysis towards pan-phenomes -- Chapter 11: Bacterial epigenomics: epigenetics in the age of population genomics -- Chapter 12: Eukaryotic pan-genomes -- Chapter 13: Computational strategies for eukaryotic pan-genome analyses.
    Abstract: This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
    Type of Medium: Online Resource
    Pages: XIV, 307 p. 47 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030382810
    DDC: 579.135
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant genetics. ; Plant biotechnology. ; Agriculture. ; Plant Genetics. ; Plant Biotechnology. ; Agriculture.
    Description / Table of Contents: Citrus origin, diffusion and economic importance -- Genetic resources of Citrus and related genera -- Conventional breeding of cultivated varieties -- Conventional breeding of rootstocks -- Ploidy manipulation as breeding strategy -- Markers, maps and marker-assisted selection -- From the draft genome of sweet orange toward a pan-genome -- New Breeding Techniques for Citrus -- From flower to fruit in citrus -- Genetic control of ripening -- Pigments in citrus: importance and genetic background -- Essential oils in citrus -- Abiotic stress resistance -- Biotechnological approaches for the resistance to citrus huanglongbling -- Genetic basis of canker resistance -- Molecular mechanisms for resistance to biotic stresses -- Future perspectives.
    Abstract: This book reviews how the release of the citrus genome facilitates the investigation of ancestral species, the study of their complex biological features, and the genetic basis of agronomic traits of paramount importance for their sustainable cultivation. The first chapters discuss citrus origin and distribution, and the economic importance and varietal composition of the cultivated species, providing an overview of citrus and related genera genetic resources. The book then describes the role of traditional breeding techniques (for scion and rootstocks) as well as the potential of genomic breeding and innovative protocols for biotechnological approaches. The second part provides essential information on the genus Citrus, the attributes of pure citrus species, genetic admixtures, hybrids and citrus relatives, and on the horticultural classification of cultivated species, varieties and rootstocks. The third part then focuses on the different molecular mechanisms, covering various aspects of citrus biology, including the role of beneficial compounds of citrus fruits. In addition, it examines the molecular responses of citrus to abiotic stresses and to field and post-harvest diseases. Providing insights gained in recent years, it is a valuable guide for those who are interested in gene discovery, comparative genomics, molecular breeding and new breeding techniques. It is particularly useful for scientists, breeders and students at universities and public sector institutes involved in research for the citrus industry.
    Type of Medium: Online Resource
    Pages: XIV, 294 p. 33 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030153083
    Series Statement: Compendium of Plant Genomes,
    DDC: 581.35
    Language: English
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  • 10
    Keywords: Medical microbiology. ; Industrial microbiology. ; Plant genetics. ; Pharmacology. ; Microbial genetics. ; Medical Microbiology. ; Industrial Microbiology. ; Plant Genetics. ; Pharmacology. ; Microbial Genetics.
    Description / Table of Contents: Chapter 1. The Artemisia genus: Panacea to Several Maladies -- Chapter 2. Bacopa monnieri: the Neuroprotective Elixir from the East: Phytochemistry, Pharmacology and Biotechnological Improvement -- Chapter 3. Current knowledge of Cinnamomum species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies -- Chapter 4. Swertia spp. : A potential source of high-value bioactive components, Pharmacology and Analytical techniques -- Chapter 5. The Genus Calophyllum: Review of Ethnomedicinal uses, Phytochemistry and Pharmacology -- Chapter 6. Plant Derived Quinones as a Source of Antibacterial and Anticancer Agents -- Chapter 7. Drugging protein-protein interaction interface with natural products: a computational approach -- Chapter 8. CQDs derived from natural sources: Excellent bio-imaging agents -- Chapter 9. Microbial Natural products: Recent insights into novel applications -- Chapter 10. Bioactive peptides and carbohydrates from natural products: a source of functional foods and nutraceuticals -- Chapter 11. Metabolites of fluorescent pseudomonads and their antimicrobial and anticancer potentials -- Chapter 12. Medicinal fungi: A natural source of pharmacologically important metabolites -- Chapter 13. Ganoderma: A propitious medicinal poroid mushroom -- Chapter 14. Pharmaceutically important metabolites from marine Fungi -- Chapter 15. Endophytic fungi: a trove of novel bioactive compounds -- Chapter 16. Novel Products from Microalgae -- Chapter 17. Lactic Acid Production and its Application in pharmaceuticals -- Chapter 18. Microbial Clot Busters: an Overview of Source, Production, Properties and Fibrinolytic Activity -- Chapter 19. Carbohydrate biopolymers: Diversity, applications and challenges -- Chapter 20. Biotechnological aspects of nanoparticles driven from natural products for drug delivery system and other applications -- Chapter 21. Methods and Techniques for the Chemical Profiling and Quality Control of Natural Products and Natural Product Driven Drugs -- Chapter 22. Characterization of Bioactive Secondary Metabolites of Fungal Endophytes -- Chapter 23. Modulation of Cellular Protein Quality Control Pathways Using Small Natural Molecules -- Chapter 24. Elaborating on the potential for mushroom-based products market expansion: Consumers’ attitudes and purchasing intentions -- Chapter 25. The Role of Algae in Nutraceutical and Pharmaceutical Production -- Chapter 26. Microbial interventions to induce secondary metabolites biosynthesis in medicinal and aromatic plants -- Chapter 27. Peptaibols: Antimicrobial peptides from Fungi.
    Abstract: This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.
    Type of Medium: Online Resource
    Pages: XII, 733 p. 96 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811513947
    DDC: 616.9041
    Language: English
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  • 11
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Cardiology. ; Therapeutics. ; Heart Surgery. ; Pharmacology. ; Cardiology. ; Therapeutics. ; Cardiac Surgery.
    Description / Table of Contents: Coronary Artery Disease: From Mechanism to Clinical Practice -- Evidence in guidelines for treatment of coronary artery disease -- Revascularization For Coronary Artery Disease: Principle And Challenges -- Antithrombotic drugs: pharmacology and perspectives -- Lipid modifying drugs: pharmacology and perspectives -- Anti-hypertensive drugs: pharmacology and perspectives -- Pharmaceutical treatment for Heart failure -- Drug discovery for coronary artery disease.
    Abstract: This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.
    Type of Medium: Online Resource
    Pages: IX, 339 p. 7 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811525179
    Series Statement: Advances in Experimental Medicine and Biology, 1177
    DDC: 615
    Language: English
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  • 12
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Animal culture. ; Physiology. ; Biochemistry. ; Conservation biology. ; Ecology . ; Embryology. ; Animal Science. ; Animal Physiology. ; Chemical Biology. ; Conservation Biology. ; Embryology.
    Description / Table of Contents: Chapter 1: Reproductive physiology in fishes -- Chapter 2: Endocrine regulation of reproduction with special emphasis on gametogenesis in fishes -- Chapter 3: Factors influencing milt quality in fishes and its usefulness to cryopreservation -- Chapter 4: Energetics of fish spermatozoa -- Chapter 5: Fish sperm quality evaluation after cryopreservation -- Chapter 6: Cryopreservation – History and Development -- Chapter 7: Cryopreservation of fish gametes- an overview -- Chapter 8: Cryopreservation and short duration storage of germ cells and male gametes of freshwater fishes -- Chapter 9: Cryopreservation of marine fish sperm -- Chapter 10: Sperm cryopreservation in crustaceans -- Chapter 11: State of the art in cryopreservation of bivalve spermatozoa -- Chapter 12: Cryopreservation of germ stem cells in fishes -- Chapter 13: Cryopreservation and storage of oocytes, embryos and embryonic cells of fish -- Chapter 14: Potential of fish gamete cryopreservation in conservation programs in Bangladesh -- Chapter 15: Gamete manipulation and conservation for genetic improvement in penaeid shrimp.
    Abstract: Understanding the reproductive physiology and endocrinology of fishes is essential for captive maturation and seed production in the field of aquaculture. Studying the spermatology of fishes is a comparatively new focus in aquaculture, which has emerged as an important area of fish research over the past two decades. In this regard, the cryopreservation of fish gametes is a crucial aspect. Moreover, energetics studies of gametes have become essential, considering the loss of vigour in the spermatozoa after cryopreservation. The latest development in this context is the cryopreservation of spermatogonial stem cell, which is also covered in the book, along with detailed information on embryo cryopreservation in fishes and crustaceans. The role of cryopreservation in conservation programmes is another important aspect, one that will especially interest biologists. This book addresses central issues in fish gamete cryopreservation and breeding, while also reviewing the history of cryopreservation. Its most unique feature is the breadth of its coverage, from basic information on reproduction in fishes, to such advanced topics as embryo cryopreservation. Chiefly intended as a handy troubleshooting guide, the book represents a valuable resource for research students in related fields.
    Type of Medium: Online Resource
    Pages: IX, 352 p. 54 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811540257
    DDC: 636
    Language: English
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  • 13
    Keywords: Biotechnology. ; Plant diseases. ; Microbial ecology. ; Bacteria. ; Biology Technique. ; Biotechnology. ; Plant Pathology. ; Microbial Ecology. ; Bacteria. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Hairy Roots Biotechnology Unzipped: A Journey of Reality and Promises -- Chapter 2. Hairy Roots as a Source of Tropane Alkaloids -- Chapter 3. Induction, Metabolite Analysis and Transgenesis of Hairy Roots From Coleus Forskohlii -- Chapter 4. Establishment of Hairy Roots of Endangered Himalayan Plantswertiachirata: A Sustainable Alternative to Extraction from Nature -- Chapter 5. A Protocol for the Selection of Spontaneous Variants From Established Catharanthusroseus Hairy Root Cultures -- Chapter 6. Strategies for the Optimization of Culture Conditions for Increasing Metabolite Production Through Hairy Root Cultures. Monoterpenoid Indole Alkaloid Production in Catharanthus Roseus Hairy Roots -- Chapter 7. Protocol for Enhanced Withaferin-a Production in Elicited Withania Somnifera (l.)Dunal Hairy Root Cultures -- Chapter 8. Establishment of Hairy Root Cultures of Pentalinonandrieuxii for the Production of Betulinic Acid -- Chapter 9. Tropane Alkaloid Production by the Establishment Of Hairy Root Cultures of Brugmansia Candida and Elicitation -- Chapter 10. Elicitation as an Essential Strategy For Enhancing Anthraquinone Accumulation In Hairy Root Cultures of Rubia Tinctorum -- Chapter 11. Establishment of Hairy Root Cultures for the Production of Biopharmaceuticals and Optimization of Methods for Recombinant Protein Secretion In The Culture Medium -- Chapter 12. An Improved Protocol for Agrobacterium Rhizogenes-Mediated Transformation of Recalcitrant Plants for Root Biology Studies: A Case Study of Tea Plants (Camellia Sinensis Var. Sinensis) -- Chapter 13 Functional Analysis of Plant Genes Related to Arbuscular Mycorrhiza Symbiosis Using Agrobacterium Rhizogenes-Mediated Root Transformation and Hairy Root Production -- Chapter 14. Functional Characterization of Genes Involved in Legume Nodulation Using Hairy Root Cultures -- Chapter 15. Fluidigm Biomark Diagnostic Panel for Analysis of the Expression of Nicotiana Tabacum Genes, Associated with Alkaloid Synthesis. .
    Abstract: The book discusses the various methods and protocols available in hairy root culture-based research. The utilization of Agrobacterium mediated genetic transformation and establishment of hairy root cultures has paved the way for large-scale secondary metabolite production in medicinal plants. Presenting recent research and offering insights from eminent research groups, the book covers a range of topics related to hairy root-based applications, including (i) establishment of hairy roots and native production of SM (ii) yield enhancement strategies for increased SM production, like elicitation (iii) hairy roots as a tool for value-added applications such as plant-microbe interaction, characterization of plant genes and root biology studies. As such it is an informative guide and experimental manual for researchers in diverse fields of plant biology.
    Type of Medium: Online Resource
    Pages: XIV, 237 p. 47 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811540554
    Series Statement: Rhizosphere Biology,
    DDC: 660.6
    Language: English
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  • 14
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Surfaces (Physics). ; System theory. ; Zoology. ; Botany. ; Biology Technique. ; Computational and Systems Biology. ; Surface and Interface and Thin Film. ; Complex Systems. ; Zoology. ; Plant Science. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Various methods of pattern formation -- Chapter 3. Clusterization of biological structures with high aspect ratio -- Chapter 4. Contact between biological attachment devices and rough -- Chapter 5. Anisotropic friction in biological systems -- Chapter 6. Mechanical interlocking of biological fasteners -- Chapter 7. Biomechanics at the microscale -- Chapter 8. Nanoscale pattern formation in biological surfaces -- Chapter 9. Ecology and evolution.
    Abstract: Basic laws of nature are rather simple, but observed biological structures and their dynamic behaviors are unbelievably complicated. This book is devoted to a study of this “strange” relationship by applying mathematical modeling to various structures and phenomena in biology, such as surface patterns, bioadhesion, locomotion, predator-prey behavior, seed dispersal, etc. and revealing a kind of self-organization in these phenomena. In spite of diversity of biological systems considered, two main questions are (1) what does self-organization in biology mean mathematically and (2) how one can apply this knowledge to generate new knowledge about behavior of particular biological system? We believe that this kind of “biomimetics” in computer will lead to better understanding of biological phenomena and possibly towards development of technical implications based on our modeling.
    Type of Medium: Online Resource
    Pages: XVIII, 317 p. 151 illus., 69 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030415280
    Series Statement: Biologically-Inspired Systems, 16
    DDC: 570.285
    Language: English
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  • 15
    Keywords: Invertebrates. ; Invertebrate Zoology.
    Description / Table of Contents: 1. Agriculture and Impact of Invasive Species to Productivity in Africa -- 2. Bioassay-Guided Isolation of Active Phytochemicals Against Tuta Absoluta (Meyrick) from Turraea Floribunda and Caesalpinia Welwitschiana -- 3. Tuta Absoluta (Meyrick): Seasonal Abundance and Susceptibility of some Tomato Genotypes in Gezira State, Sudan -- 4. Evaluation of Resistance and Toxicity of different Insecticides on Tuta absoluta Meyrick Populations in Major Tomato Growing States of Nigeria -- 5. The First Effort at Adopting Integrated Pest Management IPM to Contain the Infestation of the Tuta Absoluta in Nigeria -- 6. New Record of Tuta Absoluta on Cowpea Vigna Unguiculata, Gezira State, Sudan -- 7. Efficacy of a Sudanese Strain of Entomopathogenic Fungus, Metarhizium Anisopliae Met. Sorokin on Puparia of Bactrocera Dorsalis Hendel, under Laboratory Conditions -- 8. Taxonomic keys to Economic Fruit Flies (Diptera: Tephritidae) of the Sudan -- 9. Injury and Yield Losses due to the Maize Stem Borer Busseola Fusca (Fuller) (Lepidoptera: Noctuidae) on Smallholder farms. -- 10. Establishment of an Exotic Parasitoid Cotesia vestalis in Coastal Areas of Kenya as Biological Control Agent of Plutella Xylostella -- 11. Enhancing Monitoring Efficiency and Management of Vectors of Maize Lethal Necrosis Disease in Kenya -- 12. Outbreak of fall Armyworm (Spodoptera Frugiperda) and its Impact in Rwanda Agriculture Production -- 13. Farmers’ Perceptions and Preferences on Pesticide use in the Management of Fall armyworm in Rwanda -- 14. Chronological Review of Fruit Fly Research and Management Practices in Sudan -- 15. Integrated Pest Management for Control the Date Palm Green Pit Scale Insect Palmapsis Phoenicis Ra (Homoptera: Asterolecaniidae) in Sudan -- 16. Use of Para-Pheromone Methyl Eugenol for Suppression of the Mango Fruit Fly, Bactrocera Dorsalis (Hendel) (Diptera:Tephritidae) in Southern Ethiopia -- 17. Sudan Thematic Implementation Plan for the Management of Invasive Red Palm Weevil (RPW), Rhynchophorus Ferrugineus (Olivier) -- 18. Management of Pests of Quarantine Importance in Ghana’s Export Vegetables (Chili, Eggplant and Ridged Gourds) -- 19. The Role of Plantwise in Improving Detection and Action on Pest Situations -- 20. Semiochemical-Baited Autodissemination Device for Managing BFT on Cowpea -- 21. Influence of Predatory Mites, Phytoseiulus Longipes Evans. on the Within-Plant Diurnal Migration and Distribution of the Red Spider Mite, Tetranychus Evansi, Baker and Pritchard on African Nightshade, Solanum Scabrum -- 22. Effects and Persistence of Endophytic Beauveria Bassiana in Tomato Varieties on Mite Density Tetranychus Evansi in the Screenhouse -- 23. Flight Behaviour and Activity Time of Tuta absoluta (Meyrick) Males Trapped on Tomato and Miscellaneous Crops, Gezira State, Sudan.
    Abstract: Invasive species, generally, affect economically important crops, thus affecting the livelihoods of millions of people along crop value chains. Typically, invasive species have high migratory capabilities and, because of plant material exchanges made during trade, they cannot be contained by one country. Usually, African countries react after a pest has invaded and established itself in the country, making the cost of mitigating the pest even more expensive. This book presents a pan-African view of the impacts of invasive insect pests on agriculture and of how invasive species impact on productivity in Africa. It not only describes their importance, but also presents a diversity of research findings in the field, ranging from the use of early warning and monitoring systems for quarantine purposes, agricultural extension, all the way to control strategies. The IPM arsenal presented in this book includes the use of botanical bioactive compounds, semiochemicals, resistant varieties, biological control agents such as entomopathogens, endophytes, predators, and natural enemies. Aspects of technology transfer strategies, regional coordination, and farmers’ perceptions have not been overlooked, because these affect the adoption of mitigation strategies. The book also presents measures that would help agricultural research services to estimate the damage and take actions for preparedness and readiness to face invasive insect pests. This starts with a basic knowledge of taxonomy to enable concerned persons to describe the insects and the vast inventory of affected crops. Physiological and ecological aspects of invasive pests are strongly highlighted to strengthen Integrated Pest Management Strategies. The threat of invasive species will remain permanent; therefore, the book encourages knowledge exchange and collaboration between researchers and scientists on the continent, while encouraging the establishment of a platform or a fund for preparedness and rapid response.
    Type of Medium: Online Resource
    Pages: XXVI, 303 p. 64 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030410834
    Series Statement: Sustainability in Plant and Crop Protection, 14
    DDC: 592
    Language: English
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  • 16
    Keywords: Evolution (Biology). ; Astrobiology. ; Planetary science. ; Evolutionary Biology. ; Astrobiology. ; Planetary Science.
    Description / Table of Contents: Preface -- Chapter 1. What is astrobiology? -- Chapter 2. Astrobiology and Planetary Sciences in Mexico -- Chapter 3. Was LUCA a Hyperthermophilic Prokaryote? The Impact-Bottleneck Hypothesis Revisited -- Chapter 4. Stromatolites, Biosignatures, and Astrobiological Implications -- Chapter 5. The global distribution of modern microbialites: not so uncommon after all -- Chapter 6. The importance of the rare biosphere for astrobiological studies and the diversification and resilience of life on Earth -- Chapter 7. Bacterial communities from deep-hydrothermal systems: the southern Gulf of California as an example of primeval environments -- Chapter 8. Andean Microbial Ecosystems: traces in hypersaline lakes about life origin -- Chapter 9. Stromatolites in crater-lake Alchichica and Bacalar lagoon -- Chapter 10. The origin and early evolution of life on Earth: A laboratory in the School of Science -- Chapter 11. Cuatro Ciénegas as an Archaean Astrobiology Park -- Index.
    Abstract: Astrobiology not only investigates how early life took hold of our planet but also life on other planets – both in our Solar System and beyond – and their potential for habitability. The book take readers from the scars on planetary surfaces made by space rocks to the history of the Solar System narrated by those space rocks as well as exoplanets in other planetary systems. But the true question is how life arose here or elsewhere. Modern comparative genomics has revealed that Darwin was correct; a set of highly conserved genes and cellular functions indicate that all life is related by common ancestry. The Last Universal Common Ancestor or LUCA sits at the base of the Tree of Life. However, once that life took hold, it started to diversify and form complex microbial communities that are known as microbial mats and stromatolites. Due to their long evolutionary history and abundance on modern Earth, research on the biological, chemical and geological processes of stromatolite formation has provided important insights into the field of astrobiology. Many of these microbialite-containing ecosystems have been used as models for astrobiology, and NASA mission analogs including Shark Bay, Pavilion and Kelly Lakes. Modern microbialites represent natural laboratories to study primordial ecosystems and provide proxies for how life could evolve on other planets. However, few viral metagenomic studies (i.e., viromes) have been conducted in microbialites, which are not only an important part of the community but also mirror its biodiversity. This book focuses on particularly interesting sites such as Andean lake microbialites, a proxy of early life since they are characterized by very high UV light, while Alchichica and Bacalar lakes are characterized by high-salt and oligotrophic waters that nurture stromatolites. However, it is only the oasis of Cuatro Ciénegas Basin in México that stored past life in its marine sediments of the Sierra de San Marcos. This particular Sierra has a magmatic pouch that moves the deep aquifer to the surface in a cycle of sun drenched life and back to the depths of the magmatic life in an ancient cycle that now is broken by the overexploitation of the surface water as well as the deep aquifer in order to irrigate alfalfa in the desert. The anthropocene, the era of human folly, is killing this unique time machine and with it the memory of the planet.
    Type of Medium: Online Resource
    Pages: VIII, 232 p. 41 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030460877
    Series Statement: Cuatro Ciénegas Basin: An Endangered Hyperdiverse Oasis,
    DDC: 576.8
    Language: English
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  • 17
    Keywords: Agriculture. ; Microtechnology. ; Microelectromechanical systems. ; Environmental chemistry. ; Nanochemistry. ; Environmental policy. ; Agriculture. ; Microsystems and MEMS. ; Environmental Chemistry. ; Nanochemistry. ; Environmental Policy.
    Description / Table of Contents: Chapter 1 - State of the art of the development of nanopesticides and their potential benefits -- Chapter 2 - Understanding the interaction of nanopesticides with plants -- Chapter 3 - Study of the interaction of nanopesticides with soil microbiota -- Chapter 4 - Methods for understanding the interaction of nanopesticides with soil and water -- Chapter 5 - State of the art in ecotoxicological assays to study the effects of nanopesticides against non-target organisms -- Chapter 6 - Nanoherbicides -- Chapter 7 - Nanoinsecticides -- Chapter 8 - Nanofungicides -- Chapter 9 - Alternative models for initial screening of nanopesticides safety -- Chapter 10 - Methods for the evaluation toxicological effects of nanopesticides in humans -- Chapter 11 - Use of DNA/RNA and nanotechnology aiming pest control -- Chapter 12 - Regulatory issues regarding Nanopesticides Chapter 13 - Nanopesticides: from the bench to the market -- Chapter 14 - Nanopesticides: risk analysis.
    Abstract: This book explores the development of nanopesticides and tests of their biological activity against target organisms. It also covers the effects of nanopesticides in the aquatic and terrestrial environments, along with related subjects including fate, behaviour, mechanisms of action and toxicity. Moreover, the book discusses the potential risks of nanopesticides for non-target organisms, as well as regulatory issues and future perspectives.
    Type of Medium: Online Resource
    Pages: XXI, 360 p. 56 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030448738
    DDC: 630
    Language: English
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  • 18
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Pediatrics. ; Pharmacology. ; Pediatrics.
    Description / Table of Contents: Anti-epileptic drugs in pediatrics -- Current and new therapies for Duchenne Muscular Dystrophy -- Lysosomal diseases -- Mitochondriopathies -- Endocrinology thyroid, pituitary, growth stimulant, growth reduction -- Bone disease – bisphosphonates -- Diabetes type 1 and 3 (insulin; sulfonylurea; others) -- Diabetes type 2 (metformin etc.) -- Dermatology – part 1 urticaria, atopic dermatitis -- Dermatology part 2, ichtyosis, psoriasis -- Cardiovascular part 1- catcholamines, inotropic -- Cardiovascular part 2 – antiarhythmica, anti hypertensives -- Nephrology – dialysis -- How to use drugs in obese children and adolescents -- Haematology – CSFs, erythropoietin -- Antiretroviral/HIV -- Clinical pharmacology and pharmacometrics to better understand physiological changes during pregnancy and neonatal life -- Antihelminth treatment -- Inflammatory bowel disease -- Constipation; laxatives -- Psychiatric diseases in children and adolescents -- Oncology – cell reducing agents part 1, part 2, part 3 -- Immunosuppressants – organ transplantation -- Bone marrow/stem cell transplantation -- Narcotic sparing approaches and the shift towards paracetamol in neonatal intensive care -- Disorders of puberty: pharmacotherapeutic strategies for management.
    Abstract: This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.
    Type of Medium: Online Resource
    Pages: VIII, 538 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504946
    Series Statement: Handbook of Experimental Pharmacology, 261
    DDC: 615
    Language: English
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  • 19
    Keywords: Evolution (Biology). ; Plant genetics. ; Genetics. ; Microbial genetics. ; Evolutionary Theory. ; Plant Genetics. ; Genetics and Genomics. ; Microbial Genetics.
    Abstract: This book presents a comprehensive overview of DNA barcoding and molecular phylogeny, along with a number of case studies. It discusses a number of areas where DNA barcoding can be applied, such as clinical microbiology, especially in relation to infection management; DNA database management; and plant -animal interactions, and also presents valuable information on the DNA barcoding and molecular phylogeny of microbes, algae, elasmobranchs, fishes, birds and ruminant mammals. Furthermore it features unique case studies describing DNA barcoding of reptiles dwelling in Saudi Arabian deserts, genetic variation studies in both wild and hatchery populations of Anabas testudineus, DNA barcoding and molecular phylogeny of Ichthyoplankton and juvenile fishes of Kuantan River in Malaysia, and barcoding and molecular phylogenetic analysis of indigenous bacteria from fishes dwelling in a tropical tidal river. Moreover, since prompt identification and management of invasive species is vital to prevent economic and ecological loss, the book includes a chapter on DNA barcoding of invasive species. Given its scope, this book will appeal not only to researchers, teachers and students around the globe, but also to general readers.
    Type of Medium: Online Resource
    Pages: VI, 267 p. 41 illus., 23 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030500757
    DDC: 576.801
    Language: English
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  • 20
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Agriculture. ; Plant physiology. ; Plant Science. ; Agriculture. ; Plant Physiology.
    Description / Table of Contents: Chapter 1. Introduction to MAPs in the North America -- Chapter 2. Dr. Duke's Phytochemical and Ethnobotanical databases, a cornerstone in the validation of ethnoveterinary medicinal plants, as demonstrated by data on pets in British Columbia -- Chapter 3. Pharmacopoeial Wild Medicinal Plants of North America -- Chapter 4. Medicinal Plant Products, a Discussion of Actual or Probable versus Perceived Sources -- Chapter 5. Juniper species in North America to the same species in Europe with respect to phytochemistry and bioactivity -- Chapter 6. Mentha Genetic Diversity at the US National Clonal Germplasm Repository in Corvallis, Oregon -- Chapter 7. Advances in the research of basil -- Chapter 8. Advances in ther research of catnip -- Chapter 9. Diversity, conservation and sustainable harvest of medicinal plants in North America -- Chapter 10. The Great botanist, Jim Duke -- Chapter 11. TBC -- Chapter 12. Taxol or the story of the American yew -- Chapter 13. The Indian Tobacco -- Chapter 14. The American Elderberry -- Chapter 15. The American Ginseng.
    Abstract: This volume is aimed at offering an insight into the present knowledge of the vast domain of Medicinal and Aromatic Plants with a focus on North America. In this era of global climate change the volume is meant to provide an important contribution to a better understanding of the diverse world of Medicinal and Aromatic Plant research, production and utilization.
    Type of Medium: Online Resource
    Pages: VIII, 342 p. 59 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030449308
    Series Statement: Medicinal and Aromatic Plants of the World, 6
    DDC: 580
    Language: English
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  • 21
    Keywords: Invertebrates. ; Applied ecology. ; Biodiversity. ; Microbial ecology. ; Conservation biology. ; Ecology . ; Forestry. ; Invertebrate Zoology. ; Applied Ecology. ; Biodiversity. ; Microbial Ecology. ; Conservation Biology. ; Forestry.
    Description / Table of Contents: 1. Preface -- 2. Improving the efficacy of biological control by ecostacking -- 3. Integrative biological control approaches in Chinese agriculture, Biodiversity enhancement for improving biological control -- 4. Perennial wildflower strips to enhance natural enemies of insect pests in Belgium -- 5. Flower strips for ecosytem services in Switzerland, Felix Herzog, Agroscope, Zurich Switzerland -- 6. Enhancement of natural control functioning of rice insect pests by manipulating biodiversity in rice-based ecosystems -- 7. Cover crops enhance biological control of insect pests in apple orchards in China -- 8. Enhancement of natural control function in aphids by intercropping and infochemical releasers in wheat ecosystem -- 9. Crop diversity and disease control,Specific techniques to enhance ecostacking -- 10. Ecological enhancement of arthropod natural enemy application in biological control -- 11. Chemical ecology of egg parasitoids in crop protection -- 12. Current knowledge on the migratory moth Autographa gamma as basis for future chemo-ecological research -- 13. The development of biocontrol products and their applications in the field -- 14. Effects of insecticides on pollen beetles (Brassicogethes aeneus) and their tersilochine parasitoids in Germany -- 15. How microbiome approaches can assist market development for biological control -- 16. Successful use of entomopathogenic nematodes to control a defoliator outbreak in an environmentally sensitive area -- 17. Bees and medicinal plants -- 18. Climate change implications -- 19. Night warming on predator-prey interactions: implications for biological control -- 20. Landscape-level drivers of biocontrol and case study from local to regional scale under climate change in China -- 21. Spotted Wing Drosophila-blueberry interactions.
    Abstract: This book is the first to integrate biological control into a conceptual framework – ecostacking - uniting all aspects of biological control and ecosystem services. In 2018 the "First International Congress of Biological Control" was organised and held in Beijing, China. The chapters highlight some of the achievements presented at the congress, worldwide. Of particular significance are the numerous contributions by Chinese researchers illustrating the remarkable progress made on developing and adopting multiple biological control strategies over vast agricultural areas, largely replacing chemical pesticides for sustainable agricultural and horticultural production. In many parts of the world including Europe, fragmented research based on short-term funding has been unable to answer to the needs to develop sustainable long-term solutions to crop protection, while colleagues in China have been successful in implementing programs that exemplify the power of the ecostacking approach. Key contributions by European and US specialists combined with the expertise and experiences by the Chinese contributors comprise the building blocks for the integration of biological control approaches into the overall frame of ecostacking. This book will lead the way to a broader, integrated adoption of biological control techniques in sustainable pest, disease and weed management supporting also the functioning of other key ecosystem services. Chapter 2 of this book is available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 248 p. 63 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030448387
    Series Statement: Progress in Biological Control, 20
    DDC: 592
    Language: English
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  • 22
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Surgery. ; Neurology . ; Nervous system Radiography. ; Neuropsychology. ; Neurosurgery. ; Neurology. ; Neuroradiology. ; Neuropsychology.
    Description / Table of Contents: History of Epilepsy Surgery -- Epilepsy: Clinical, Epidemiological, and Therapeutical Aspects -- Presurgical Evaluation -- Surgical Tools and Techniques -- Anesthesia -- Temporal Lobe Resections -- Extratemporal Resections -- Hemispherical Procedures -- Long-Term Epilepsy-Associated Tumors (LEATs) -- MRI-Negative Epilepsies -- Pediatric Epilepsy Surgery -- Reoperations after failed surgery -- Pathology in Epilepsy Surgery -- Non-Resective Epilepsy Surgery -- Complications -- Cost-Effectiveness of Epilepsy Surgery -- The current Place of Epilepsy Surgery -- A personal view.
    Abstract: This book fills the gap between the increasing demand for epilepsy surgical experience and limited training facilities in this area. It comprehensively describes surgical techniques, including tricks and pitfalls, based on the author’s 30 years of experience, providing optimal and effective training for young neurosurgeons by avoiding learning by trial and error. Moreover, it also includes useful information for epileptologists and other professionals involved in the epilepsy surgical program to allow them to gain a better understanding of possibilities and limitations of epilepsy surgery. .
    Type of Medium: Online Resource
    Pages: XXI, 404 p. 154 illus., 111 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030487485
    DDC: 617.48
    Language: English
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  • 23
    Keywords: Conservation biology. ; Ecology . ; Environment. ; Biotechnology. ; Pollution. ; Earth sciences. ; Geography. ; Conservation Biology. ; Environmental Sciences. ; Biotechnology. ; Pollution. ; Earth and Environmental Sciences.
    Description / Table of Contents: Preface -- Concerns and Threats of Heavy Metals Contamination on Aquatic Ecosystem -- Pollution in Aquatic Environs: Sources and consequences -- A Recent Scenario of Groundwater Quality in Northwest Himalaya, India -- Polycyclic aromatic hydrocarbons: Toxic Effects and their Bioremediation Strategies -- Mechanisms and importance of phytoremediation -- Role of Soil Biota and Associated Threats -- Viability of in-situ and ex-situ bioremediation approaches for degradation of noxious substances in stressed environs -- Bioremediation: A viable approach for degradation of petroleum hydrocarbon -- Application of macrophytes for remediation of wastewater in constructed wetlands -- Application of Biotechnology for restoration of degraded environs -- Role of Free Floating Aquatic Macrophytes in abatement of the disturbed Environs -- Genetically Modified Microbes as Biofertilizers -- Nanotechnology: A Modern Waste management approach -- Restoration of Heavy Metal Contaminated Environs through Ectomycorrhizal Symbiosis -- Index.
    Abstract: The rapid thriving of industries, conversion of agricultural land to residential areas, habitat destruction, deforestation and use of recalcitrant synthetic substances enhanced the rate of degradation of the environment. Although there are various conventional techniques for degradation and cleaning of noxious pollutants from disturbed environs, they are energy inefficient and costly to install. Bioremediation has emerged recently as an alternative and novel approach to manage and control environmental pollutants. This volume focuses explicitly on the remediation of noxious substances in stressed environs. It includes expert-contributed chapters on bio-monitoring by way of evaluating the relationship of biota with the polluted/stressed environs, sustainable plant-based degradation of noxious pollutants, and the application of biotechnologies to achieve tailored responses. Academicians, researchers, scientists and students will find this work essential for sustainable treatment of noxious pollutants. This book also serves as a core guide for training, teaching and research in conservation biology and environmental rehabilitation.
    Type of Medium: Online Resource
    Pages: XX, 340 p. 41 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030486907
    DDC: 333.9516
    Language: English
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  • 24
    Keywords: Biodiversity. ; Agriculture. ; Forestry. ; Plant biotechnology. ; Plant diseases. ; Energy policy. ; Energy and state. ; Biodiversity. ; Agriculture. ; Forestry. ; Plant Biotechnology. ; Plant Pathology. ; Energy Policy, Economics and Management.
    Description / Table of Contents: Genetically modified organisms (GMOs) impact and current status in Latin America: technological sovereignty or dependence? -- New biotechnology promising approaches for disease control on bananas and plantains -- Complementation of bananas conventional breeding programs through biotechnological genetic improvement -- The stress as inducer of heritable changes in micropropagated banana: the hypothesis of cytokinin accumulation -- Somatic embryogenesis for clonal propagation and associated molecular studies in cacao (Theobroma cacao L.) -- Use of biotechnology in Forestry breeding programs for natural resources and biodiversity conservation; Creating super trees for the future -- Stress modulation in Pinus spp. Somatic embryogenesis as model for climate change mitigation; Stress is not always a problem -- A Protective Role for Accumulated Dry Matter Reserves in Seeds During Desiccation: Implications for Conservation -- Biodiversity in Ecuador and its immense potential for agricultural pest control -- Native biodiversity: a strategic resource to accelerate bioeconomy development in Latin America and the Caribbean -- Low cost crop waste biosorbent technology for removing toxic and pollutants from wastewater -- The status of plant and plant-microbe interactions related to medicinal agents -- Bringing new function to packaging materials by agricultural byproducts -- Use of banana crop wastes to develop products in the aquaculture and plastic sectors -- Use of agroindustrial biomass for biofuels, enzymes discovery and production -- Temperature Profiles during the Fermentation of Cacao ‘Nacional’ to understand chocolate quality -- Ethno Phytopharmacology. Product validation process based on traditional knowledge of medicinal plants -- Biological control as a key tool for the management of invasive species in Latin America and the Caribbean -- Current research on Andean fruit crop diseases -- Biotechnological tools for the development of Foc TR4-resistant or tolerant Musa spp. Cultivars -- Integrated pest management of whitefly crop-free periods can reduce the Begomovirus transmission in tomato.
    Abstract: Food security, crop protection, biodiversity, and human and environmental health are among the main needs and concerns of society. Modern biotechnology and life sciences represent a constantly evolving area that is key for the rational use of natural resources – resources that in turn are indispensable for societal development. This book features the outcomes of the IV International Biotechnology and Biodiversity Congress, held in Guayaquil, Ecuador, 2018. It includes extensive reviews of the trends in agricultural and forestry biotechnology, molecules and materials biodiscovery, ethnomedicine, environmental impact and bioindustry research, describing many of these topics from the Latin America perspective and showing how the biodiversity and ancient knowledge of these countries are vital for worldwide sustainable development. .
    Type of Medium: Online Resource
    Pages: XIX, 460 p. 82 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030513580
    DDC: 333.95
    Language: English
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  • 25
    Keywords: Neurosciences. ; Otorhinolaryngology. ; Neuroscience. ; Otorhinolaryngology.
    Description / Table of Contents: Ch 1: Listening to All Voices: Interdisciplinary Approaches to Understanding Hearing in Aging -- Ch 2: Genetic and Molecular Aspects of the Aging Auditory System -- Ch 3: The Aging Cochlea and Auditory Nerve -- Ch 4: Age-Related Changes in the Auditory Brainstem and Inferior Colliculus -- Ch 5: Age related changes in the primate auditory cortex -- Ch 6: The Aging Auditory System: Electrophysiology -- Ch 7: Age-Related Changes in Segregation of Sound Sources -- Ch 8: Causes and Consequences of Age-Related Hearing Loss -- Ch 9: Age-Related Changes in Speech Understanding: Peripheral versus Cognitive Influences -- Ch 10: Aging, Hearing Loss, and Listening Effort: Imaging Studies of the Aging Listener -- Ch 11: Functional Consequences of Impaired Hearing in Older Adults and Implications for Intervention -- Ch 12: Emerging Clinical Translational Treatment Strategies for Age-Related Hearing Loss.
    Abstract: This volume provides contemporary discussions on new developments in aging research. It serves as an important update on the current state of research on the aging auditory system. Listening to All Voices: Interdisciplinary Approaches to Understanding Hearing in Aging Karen S. Helfer and Edward L. Bartlett Genetic and Molecular Aspects of the Aging Auditory System Shinichi Someya and Mi-Jung Kim The Aging Cochlea and Auditory Nerve Kevin K. Ohlemiller and Christopher Spankovich Age-Related Changes in the Auditory Brainstem and Inferior Colliculus Josef Syka Age-Related Changes in the Primate Auditory Cortex Gregg Recanzone The Aging Auditory System: Electrophysiology Kelly C. Harris Age-Related Changes in Segregation of Sound Sources Frederick J. Gallun and Virginia Best Causes and Consequences of Age-Related Hearing Loss Jennifer A. Deal, Nicholas S. Reed, Emily C. Pedersen, and Frank R. Lin Age-Related Changes in Speech Understanding: Peripheral versus Cognitive Influences Sandra Gordon-Salant, Maureen J. Shader, and Arthur Wingfield Aging, Hearing Loss, and Listening Effort: Imaging Studies of the Aging Listener Stefanie E. Kuchinsky and Kenneth I. Vaden, Jr. Functional Consequences of Impaired Hearing in Older Adults and Implications for Intervention Larry E. Humes, M. Kathleen Pichora-Fuller, and Louise Hickson Emerging Clinical Translational Treatment Strategies for Age-Related Hearing Loss Robert D. Frisina, Carlos J. Cruz, Tanika T. Williamson, Xiaoxia Zhu, and Bo Ding .
    Type of Medium: Online Resource
    Pages: XVII, 323 p. 62 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030493677
    Series Statement: Springer Handbook of Auditory Research, 72
    DDC: 612.8
    Language: English
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  • 26
    Keywords: Paleoecology. ; Paleontology . ; Bioinformatics. ; Archaeology. ; Earth sciences. ; Paleoecology. ; Paleontology. ; Computational and Systems Biology. ; Archaeology. ; Earth Sciences.
    Description / Table of Contents: Chapter 1-Introduction -- Chapter 2-Historical perspective -- Chapter 3-Geology and stratigraphy -- Chapter 4-Indian late cretaceous dinosaur nesting sites -- Chapter 5-Discussion. Chapter -- 6-Summary and conclusions.
    Abstract: This book documents analyses of the Late Cretaceous dinosaur nesting sites of the Lameta Formation at Jabalpur, Districts Dhar and Jhabua, Madhya Pradesh; Districts Kheda and Panchmahal (Gujarat); and the Pisdura, Dongargaon and Pavna sectors in the Chandrapur Districts of Maharashtra, which are exposed in India along an east-west and central axis. In this work, special emphasis has been given to the dinosaur nesting sites of the east-central Narbada River region, including its regional geology. The work was undertaken to provide detailed information concerning dinosaur eggs, eggshell fragments, nests and clutches found in the Lameta Formation of peninsular India. Prior to the present work there had been no detailed review of systematic work on the taxonomy, and of micro- and ultrastructural studies of dinosaur eggs and eggshells from the Lameta Formation. The study documents the field and laboratory investigations that facilitated the reconstruction of the morphotaxonomy, models for the burial pattern of eggs and eggshells, taphonomic implications,and the palaeoenvironmental context and palaeoecological conditions during the Late Cretaceous at the time of the extrusion of the Deccan traps, which may have been partly responsible for the extinction of the dinosaurs. The need to follow a parataxonomic classification for Indian dinosaur eggs and eggshell types is very apparent, and this book addresses this aspect in some detail. The emphasis on the application of parataxonomic schemes is based on the description of new oospecies and their comparison with previously known forms. The present work has led to the recovery of numerous nests, many collapsed eggs and hundreds of dinosaur eggshell fragments from the localities situated near the east, west and central Narbada River regions. It will be of interest to academics and professional palaeontologists, and all students of dinosaurs.
    Type of Medium: Online Resource
    Pages: XX, 280 p. 92 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030564544
    Series Statement: Topics in Geobiology ; 51
    DDC: 560.45
    Language: English
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  • 27
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant diseases. ; Agriculture. ; Conservation biology. ; Ecology . ; Plant Pathology. ; Agriculture. ; Conservation Biology.
    Description / Table of Contents: I. Biology of Plant defence -- 1.Plant defense in biological pest control -- 2. Specialized metabolites and plant defence -- 3.Sources of variation in defensive traits in Quercus species -- 4.Glycans as Modulators of Plant Defense -- 5.Biological Control and Need of a Strategic Shift -- II. Use of natural compounds -- 6.Polyphenolic Compounds Obtained from OMWW -- 7.small molecules of natural origin -- 8.Pinus polyphenols and antifungal activities -- 9.stilbenoid-enriched grape cane extracts in biocontrol -- III. Use of biological agents -- 10.Biological control of postharvest diseases -- 11.Sorghum allelopathy for sustainable weed management -- 12.Chaetomium as biocontrol agent on plant pathogens -- 13.Fusaria strains as biocontrol agents -- 14. Fungi as biological control -parasitic nematodes -- 15.Control of pepper powdery mildew -- 16.Molecular Mechanisms of Nematode- Microbe Interactions -- VI. Market and commercialization -- 17.Trends for commercialization of Biocontrol Agent.
    Abstract: Insects, pests and weeds are responsible for substantial loss of crops and reduced food supplies, poorer quality of agricultural products, economic hardship for growers and processor. Generally, chemical control methods are neither always economical nor are they effective and may have associated unwanted health, safety and environmental risks. Biological control involves use of beneficial biological agents to control pests and offers an environmental friendly approach to the effective management of plant diseases and weeds. The chapters are written by well recognized group leaders in the field. This book provides a comprehensive account of interaction of host and pests, and development of biological control agents for practical applications in crops management utilizing inherent defence mechanism, induced stimulation and biological control agents. The contents are divided into the following sections: General biology of plant defence, Use of natural compounds for biological control, Use of biological agents, Mechanism of action and Commercial aspects. The book will be useful for academicians, researcher and industries involved in study and manufacturing these products.
    Type of Medium: Online Resource
    Pages: X, 478 p. 72 illus., 54 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030510343
    Series Statement: Progress in Biological Control, 22
    DDC: 571.92
    Language: English
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  • 28
    Keywords: Medical microbiology. ; Diseases. ; Microbiology. ; Medical Microbiology. ; Diseases. ; Microbiology.
    Description / Table of Contents: Chapter 1: The INFECT-project: An international multidisciplinary project on necrotizing soft tissue infections -- Chapter 2: Necrotizing Soft Tissue Infections: case reports from the patients prospective -- Chapter 3: Necrotizing soft tissue infections: Case-reports, from the clinician’s perspectives -- Chapter 4: Necrotizing soft tissue infections: clinical features and diagnostic aspects -- Chapter 5: Microbiological etiology of necrotizing soft tissue infections -- Chapter 6: Beta-hemolytic streptococci and necrotizing soft tissue infections -- Chapter 7: Treatment of necrotizing soft tissue infections: Antibiotics -- Chapter 8: Treatment of necrotizing soft tissue infections: IVIG -- Chapter 9: Pathogenic mechanisms of streptococcal necrotizing soft tissue infections -- Chapter 10: Systems genetics approaches in mouse models of Group A Streptococcal necrotizing soft tissue infections -- Chapter 11: Systems biology and biomarkers in necrotizing soft tissue infections -- Chapter 12: Systems and precision medicine in necrotizing soft tissue infections.
    Abstract: This volume aims to enhance the current understanding of clinical features, treatment and pathogenic aspects in necrotizing soft tissue infections. Various representative case studies are discussed to enhance the readers’ understanding of these complex diseases. Necrotizing soft tissue infections are rapidly spreading infections that may cause extensive soft tissue or limb loss, multiorgan failure and are associated with a considerable fatality rate. It is undisputed that rapid diagnosis and prompt intervention is directly related to survival. The initial presentation may be limited to unspecific symptoms such as tenderness, swelling, erythema and pain. Thus, diagnosis and management are challenging due to heterogeneity in clinical presentation, in co-morbidities, in microbiological aetiology, as well as in the pathogenic mechanisms. An international and multidisciplinary consortium, INFECT, has for the last 6 years been pursuing research aimed to advance the understanding of the clinical and pathogenic aspects of these infections. A central part has been to create a comprehensive clinical registry and associated biobank which have also formed the basis for the experimental studies. Using the INFECT patient cohort, as well as an integrated systems biology approach in patients and clinically relevant experimental models, an advanced insight of diagnostic features, causative microbial agents, treatment strategies, and pathogenic mechanisms (host and bacterial disease traits and their underlying interaction network) has been obtained.
    Type of Medium: Online Resource
    Pages: VIII, 207 p. 60 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030576165
    Series Statement: Advances in Experimental Medicine and Biology, 1294
    DDC: 616.9041
    Language: English
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  • 29
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biomaterials. ; Nucleic acids. ; Bioinformatics. ; Biology Technique. ; Nucleic Acid. ; Computational and Systems Biology. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Strategies in Life sciences -- Chapter 2. Management and Manufacturing process of biologics -- Chapter 3. Downstream processes -- Chapter 4. Bioprinting -- Chapter 5. Biopharmaceuticals: New Frontier.
    Abstract: Tailoring of biomolecules using protein engineering technology, and host cells culture techniques are among the most sophisticated and elegant achievements of modern applied life sciences in which the basic fundamentals biotechnology are applicable for the development and manufacturing of biologics and other related bio-molecules for a hurdle free life with good health. A majority of biologics derived from genetically modified host cells in the current market are bio-formulation such as antibodies, nucleic acid products and vaccines. Such bio-formulations are developed mainly in two steps i.e. upstream process and downstream process. The first volume of this series begins with the latest information on how the classical stepwise host cells culture (mammals, animals, plants, and bacteria) methodology has been changed to fully continuous or partially continuous host cells culture process in order to economise the biopharmaceutical products manufacturing process. In addition this volume narrates a brief history on conceptual development of new thoughts in designing biotechnology industries for commercial production of variety of therapeutic proteins with structural modification on the basis of clinical requirements. The readers will feel exited by going through the latest discovery and development in applied life sciences for designing innovative biomolecules for health care with utmost safe. The most interesting part of this volume is newly developed concept on bioprinting. It explains how to design and fabricate animate objects by fusing or depositing material of interest in the form of powders, solid dusts, metal, liquid or even living cells or tissues by layers to produce 3D objectives. The first volume ends with the latest information on the current trend in biologics market, market dynamic, drives, and opportunities with challenges.
    Type of Medium: Online Resource
    Pages: XV, 189 p. 84 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811575907
    Series Statement: New Paradigms of Living Systems, 1
    DDC: 620.19
    Language: English
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  • 30
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: MicroRNAs in the tumor microenvironment -- The Impact of Estrogen in the Tumor Microenvironment -- The non-bone related role of RANK/RANKL signaling in cancer -- Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment -- Exosomes: Novel Players of Therapy Resistance in Neuroblastoma -- COX-2 Signaling in the Tumor Microenvironment -- Renin–angiotensin system in the tumor microenvironment -- Stem cell secreted factors in the tumor microenvironment -- Tight interplay between therapeutic monoclonal antibodies and the tumor microenvironment in cancer therapy -- Tumor Microenvironment & Nitric Oxide: Concepts and Mechanisms -- Index.
    Abstract: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIV, 162 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030502249
    Series Statement: Advances in Experimental Medicine and Biology, 1277
    DDC: 571.978
    Language: English
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  • 31
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Atoms. ; Molecules. ; Biotechnology. ; Atomic, Molecular and Chemical Physics.
    Description / Table of Contents: Photonic crystals for biomolecule sensing applications -- Recent advances in Surface Plasmon Resonance for biosensing applications and future prospects -- Surface-enhanced Raman Scattering for biology and medicine -- Nanophotonic techniques for single cell analysis -- Biointerface Characterization by Nonlinear Optical Spectroscopy -- Chemiluminescence and its biomedical applications -- Luminescent Conjugated Polymer Dots for Biomedical Applications -- Dark-Field Hyperspectral Imaging (DF-HSI) Modalities for Characterization of Single Molecule and Cellular Processes -- Additive Manufacturing Technologies based on Photopolymerization.
    Abstract: This book summarizes the latest advances in nanophotonics for biomedical applications, including biomolecular sensing and imaging, additive fabrications, and biophotonics. The engineering of nanophotonics will have significant impacts on the life sciences and medicine alike. Given its scope, the book offers a valuable asset for researchers, scientists, engineers, and graduate students in the fields of biomedical engineering, electrical engineering, materials sciences, optics, biology, and medicine.
    Type of Medium: Online Resource
    Pages: V, 282 p. 160 illus., 126 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811561375
    DDC: 660.6
    Language: English
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  • 32
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Botany. ; Plant genetics. ; Plant ecology. ; Plant Science. ; Plant Genetics. ; Plant Ecology.
    Description / Table of Contents: Preface -- Acknowledgement -- Chapter 1. Taxonomic History -- Chapter 2. Morphology -- Chapter 3. Biology -- Chapter 4. Economic Importance -- Chapter 5. Phylogeny, classification, and biogeography -- Chapter 6. Taxonomic revision -- Chapter 7. Conservation status.
    Abstract: This book provides essential information on the morphology, biology, phytochemistry, pharmaceutical prospects, evolution, phylogeny, biogeography, and taxonomy of Paris (Melanthiaceae), a morphologically distinctive plant genus with great economic importance. Since the establishment of this genus, 70 species and 24 subspecific taxa have been described, resulting in considerable confusion in species delimitation. In this book, the taxonomy of all described taxa is carefully revised. Based on multi-disciplinary evidences, a revised classification system of Paris containing five sections is outlined. Every species is provided with a concise but diagnostic description, a color illustration, photographs that highlight distinguishing characters, examined specimens and distribution range. The interspecific relationships are clarified with an identification key. This monograph offers taxonomists, evolutionary biologists, ecologists, horticulturalists, phytochemists, and practitioners a thorough and up-to-date overview about this interesting plant group. It is equally valuable for undergraduate and graduate students, teachers and professionals engaged in related fields.
    Type of Medium: Online Resource
    Pages: XIII, 203 p. 134 illus., 110 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811579035
    DDC: 580
    Language: English
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  • 33
    Keywords: Conservation biology. ; Ecology . ; Biotic communities. ; Population biology. ; Animal migration. ; Conservation Biology. ; Theoretical and Statistical Ecology. ; Community and Population Ecology. ; Animal Migration.
    Description / Table of Contents: Chapter 1. The conservation issue -- Chapter 2. Development of hierarchical spatial models for assessing ungulate abundance and habitat relationships -- Chapter 3. Model-based assessment of ungulate-habitat relationships -- Chapter 4. Assessing threats to ungulates and management responses -- Chapter 5. Conservation of tropical forest ungulates: the way forward.
    Abstract: Large ungulates in tropical forests are among the most threatened taxa of mammals. Excessive hunting, degradation of and encroachments on their natural habitats by humans have contributed to drastic reductions in wild ungulate populations in recent decades. As such, reliable assessments of ungulate-habitat relationships and the spatial dynamics of their populations are urgently needed to provide a scientific basis for conservation efforts. However, such rigorous assessments are methodologically complex and logistically difficult, and consequently many commonly used ungulate population survey methods do not address key problems. As a result of such deficiencies, key parameters related to population distribution, abundance, habitat ecology and management of tropical forest ungulates remain poorly understood. This book addresses this critical knowledge gap by examining how population abundance patterns in five threatened species of large ungulates vary across space in the tropical forests of the Nagarahole-Bandipur reserves in southwestern India. It also explains the development and application of an innovative methodology – spatially explicit line transect sampling – based on an advanced hierarchical modelling under the Bayesian inferential framework, which overcomes common methodological deficiencies in current ungulate surveys. The methods and results presented provide valuable reference material for researchers and professionals involved in studying and managing wild ungulate populations around the globe. .
    Type of Medium: Online Resource
    Pages: XXVII, 195 p. 46 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811569340
    DDC: 333.9516
    Language: English
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  • 34
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Conservation biology. ; Ecology . ; Agriculture. ; Environmental health. ; Botany. ; Landscape ecology. ; Conservation Biology. ; Agriculture. ; Environmental Health. ; Plant Science. ; Landscape Ecology.
    Description / Table of Contents: Chapter1. Taming the Land, A Historical Perspective -- Chapter2. The Ecological Connection in Farming, Ranching, and Gardening -- Chapter3. Hydrology and Erosion Processes -- Chapter4. Cover Crop Dynamics on Hydrology and Erosion -- Chapter5. Vegetation Effects on Hydrology and Erosion: Grazinglands -- Chapter6. Organic Matter: The Whole Truth and Nothing but the Truth -- Chapter7. Soil-Hydrology-Plant Assessment Technologies for Cropland, Rangeland, Pastureland, and Gardens.
    Abstract: This book explores the importance of soil health in croplands, rangelands, pasturelands, and gardens, and presents new methods and technologies for assessing soil dynamics and health in these different land types. Through perspectives of agriculture, soil management, and ecological sustainability, the book provides accurate and up-to-date information on soil health assessment and maintenance that is often missing from current literature on conservation and environmental management and preservation. The book is written in a clear and concise format, and will appeal to non-scientists interested in soil health, as well as professional farmers, ranchers and gardeners. The book begins by discussing soil health from a historical perspective, and in terms of how it is covered in the news currently. Then the author addresses the ecological implications of soil health in farming, ranching and gardening, and comprehensively details the physical, chemical and biological properties of soil as they apply in various land types. The book then examines soil health assessment using new diagnostic and analytic technologies, and how these new innovations will be necessary going forward to maintain and improve soil health. .
    Type of Medium: Online Resource
    Pages: IX, 370 p. 119 illus., 69 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030403980
    DDC: 333.9516
    Language: English
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  • 35
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Biochemical markers. ; Immunotherapy. ; Cancers. ; Biomarkers. ; Immunotherapy.
    Description / Table of Contents: 1 Tumor heterogeneity: challenges and perspectives for gastrointestinal cancer therapy -- 2 immune composition of gastrointestinal tract of Gut -- 3 Immunomarkers for detection of GI malignancies -- 4 Immuno-therapeutics of gastrointestinal malignancies -- 5 Immune cell therapy against gastrointestinal tract cancers -- 6 Immune checkpoint inhibitors in gastrointestinal malignancies -- 7 Monoclonal Antibody therapy against gastrointestinal tract cancers -- 8 Therapeutic Vaccines for Gastrointestinal Malignancies -- 9 Immuno-Oncology of Oesophageal Cancer -- 10 Association between IL6 gene polymorphisms and gastric cancer risk: A meta-analysis of case-control studies -- 11 Immuno-oncology of colorectal cancer -- 12 Immune targets in colorectal cancer -- 13 Applications of computational biology in gastrointestinal malignancies. .
    Abstract: This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies. .
    Type of Medium: Online Resource
    Pages: XII, 251 p. 34 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811564871
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    DDC: 571.978
    Language: English
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  • 36
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Reproduction. ; Physiology. ; Anatomy. ; Cytology. ; Human Physiology. ; Reproductive Physiology. ; Anatomy. ; Cell Biology.
    Description / Table of Contents: Chapter 1: Introduction -- Chapter 2: Origin and development of the breast -- Chapter 3: Structure of the lactating breast -- Chapter 4: Breast function during the initial period of lactation (lactogenesis I and II) -- Chapter 5: The period of established lactation (lactogenesis III).
    Abstract: This comprehensive Monograph examines all peripheral and central mechanisms of regulating the secretion of milk from the lactating breast. The author reviews the complete female breast development, starting with the early childhood, up to pregnancy and lactation. Structural and ultrastructural data on the alveolar-ductal system, together with details of breast innervation, are used to investigate the physiological process of lactation. Readers will appreciate the special focus on reflexes, both in the child and the mother, that help to regulate maternal milk production and secretion. Following this, the author sheds a light on the composition and dynamics of milk components during the different periods of lactation. The final section of this volume focusses on practical aspects of modern breastfeeding, like the use of breast pumps or galactogogues, to influence the productivity of milk production. These fundamental principles and structural details will be particularly useful for physiologists and clinicians working in gynecology and pediatrics.
    Type of Medium: Online Resource
    Pages: VIII, 254 p. 87 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030663643
    DDC: 612
    Language: English
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  • 37
    Keywords: Microbiology. ; Biotechnology. ; Refuse and refuse disposal. ; Microbiology. ; Biotechnology. ; Waste Management/Waste Technology.
    Description / Table of Contents: Part 1 Introductory Chapters -- 1 Emerging Frontiers of Microbes as Agro-waste Recycler -- 2 Microbes: the next generation bioenergy producers -- 3 Emerging and eco-friendly approaches for waste management -- 4 Ecofriendly microbial biofuel production from waste -- 5 Bioremediation: Current research trends and applications -- 6 Bioremediation: an approach for environmental pollutants detoxification -- 7 Bioethanol extraction and its production from agricultural residues for sustainable development -- Part 2 Biotechnological approaches -- 8 Byproduct valorization of vegetable oil industry through biotechnological approach -- 9 Omics tools: Approaches for microbiomes analysis to enhance bioenergy production -- 10 Omics (genomics, proteomics, metabolomics etc.) tools to study the environmental microbiome and Bioremediation -- Part 3 Industrial waste management -- 11 Microalgae: Omics approaches for biofuel production and biomedical research -- 12 Waste Utilization and Minimization in Food Industry.-13 Ligninolytic microbes and their role in effluent management of pulp and paper industry -- 14 Production of Polyhydroxyalkanoates using waste as raw materials. 15 Newer Aspects of Waste-to-Valorisation Technologies in Food Industry -- 16 Xylanase in waste management and its industrial applications -- 17 Organic Acid Production from Agricultural Waste. .
    Abstract: This book addresses waste generation problems from various sectors, including industries, agriculture, and household. It focuses on how modern biotechnological approaches could help manage waste in an eco-friendly manner and generate precious bioenergy. It discusses the inadequate waste management systems damaging the environment and its adverse impacts on climate change-related problems. This book covers all the essential information regarding various types of waste and their management. It is a comprehensive compilation for understanding the efficient generation of bioenergy. It is a relevant reading material (resource) for anyone who wishes to study waste management as Chemist, Biologist, Biotechnologist, Industrialist, Ecologist, Microbiologist, Economist, and all disciplines related to the environment.
    Type of Medium: Online Resource
    Pages: VIII, 438 p. 60 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813343474
    DDC: 579
    Language: English
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  • 38
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Food Microbiology. ; Food science. ; Food Microbiology. ; Food Science.
    Description / Table of Contents: Chapter One Why encapsulate antioxidants in emulsion-based systems, where they are located, and how location affects their efficiency -- Chapter Two High-energy emulsification methods for encapsulation of lipid-soluble antioxidants -- Chapter Three Low-energy emulsification methods for encapsulation of antioxidants -- Chapter Four Nanoemulsions as carriers for natural antioxidants: formulation development and optimization -- Chapter Five Microemulsions as antioxidant carriers -- Chapter Six Membrane emulsification for encapsulation of bioactives: Application to the encapsulation of antioxidants -- Chapter Seven Encapsulation of antioxidants using double emulsions -- Chapter Eight Stability and release behavior of bioactive compounds (with antioxidant activity) encapsulated by Pickering emulsion -- Chapter Nine Advances in the oxidative stability mechanisms of emulsions -- Chapter Ten The role of antioxidants and encapsulation processes in omega-3 stabilization -- Chapter Eleven Encapsulation of pigmented lipophilic antioxidants through micro and nanoemulsions -- Chapter Twelve Characterization techniques for emulsion-based antioxidant carriers with biomedical applications.
    Abstract: The limited aqueous solubility of bioactive pharmaceutical ingredients presents a tremendous challenge in the development of new drugs. In recent years, methods have been developed to protect these sensitive bioactive compounds, namely antioxidants, with the aim of increasing the public sanitation grades. Emulsion-based systems are particularly interesting as colloidal delivery encapsulation systems, because they can easily be created from food-grade ingredients using relatively simple processing protocols. It is one of the most favorable delivery systems to increase the solubility of phytochemicals, nutraceuticals and food additives. Emulsion‐based Encapsulation of Antioxidants: Design and Performance advances the field of colloid science through the investigation of the effects of formulation and process parameters that influence emulsion production. The book offers a deeper comprehension of the technological and biological aspects of the incorporation of encapsulated compounds in food matrices and explication of their activity. Chapters provide an overview of the status of emulsion-based formulations to encapsulate antioxidants, fabrication, properties, applications, and biological fate with emphasis on systems suitable for utilization within industry. Special emphasis is placed on the antioxidant activity of the carriers being the key advantage of these emulsion-based systems. The main aim of the book is to inspire and to guide fellow scientists and students in this field. Filled with illustrations, figures, case studies, practical examples, and historical perspectives, the book can also be used as a practical handbook or graduate textbook. For industry professionals, the book presents easy-to-achieve approaches to industrial pharmaceutical production. .
    Type of Medium: Online Resource
    Pages: XIII, 473 p. 96 illus., 75 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030620523
    Series Statement: Food Bioactive Ingredients,
    DDC: 664.001579
    Language: English
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  • 39
    Keywords: Pharmacology. ; Cardiology. ; Neurosciences. ; Clinical biochemistry. ; Pharmacology. ; Cardiology. ; Neuroscience. ; Medical Biochemistry.
    Description / Table of Contents: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.
    Abstract: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 425 p. 70 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030685102
    Series Statement: Handbook of Experimental Pharmacology, 264
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Proteins . ; Biotechnology. ; Enzymology. ; Bioorganic chemistry. ; Protein Biochemistry. ; Chemical Bioengineering. ; Enzymology. ; Bioorganic Chemistry.
    Description / Table of Contents: Preface -- Chapter 1: Introduction -- Chapter 2: Enzyme Cascade Design – Retrosynthesis Approach -- Chapter 3 : Multi-Enzymatic Cascades in vitro -- Chapter 4: Multi-Enzymatic Cascades in vivo -- Chapter 5: Chemo-Enzymatic Cascades -- Chapter 6: Enzyme Cascade Kinetic Modelling -- Chapter 7: Enzyme Cascade Reaction Engineering -- Chapter 8: Enzyme Cascade Process Design and Modelling -- Chapter 9: Enzyme Cascade Reaction Monitoring And Control -- Chapter 10: Cascade reactions in non-conventional media -- Chapter 11: Perspectives.
    Abstract: This book provides a comprehensive overview of the recent developments achieved in the field of chemo/enzymatic cascades with topics spanning from design (in vitro and in vivo) to kinetic- and process modelling as well as process control. Opportunities and challenges of building multi-step chemo/enzymatic reactions are discussed, whereby the latter are critically assessed in each chapter and methods to ease the implementation are explored. Both, multi-enzymatic cascades and chemo-enzymatic cascades are presented with the motivation of combining the strengths of these two worlds (e.g. selectivity, activity and robustness) not neglecting the obstacles and challenges of such endeavour. Furthermore, the use of non-conventional media for catalytic cascade reactions, recent achievements and potential for future developments in a technical environment are addressed.
    Type of Medium: Online Resource
    Pages: VII, 181 p. 103 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030657185
    DDC: 572.6
    Language: English
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  • 41
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Radiology. ; Spectrum analysis. ; Pharmaceutical chemistry. ; Nutrition   . ; Biomedical Research. ; Radiology. ; Spectroscopy. ; Pharmaceutics. ; Nutrition.
    Description / Table of Contents: Ch 1: Electron Spin Resonance- An Introdcution -- Ch 2: ESR – Applications in Healthcare and Pharmaceutical Science -- Ch 3: ESR Applications in Paleontology and Geochronology -- Ch 4: ESR Applications in Food Science.
    Abstract: This book introduces the audience with basic theoretical and experimental aspects of Electron Spin Resonance (ESR) Spectroscopy. It further talks about ESR spectroscopy applications in Healthcare & Pharmaceutical Science, Paleontology & Geochronology and Food Science. Mathematical details have been kept to a necessary minimum and emphasis is given to highlight the applications of the technique.
    Type of Medium: Online Resource
    Pages: X, 72 p. 32 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030641986
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    DDC: 610.72
    Language: English
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  • 42
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Bioinformatics. ; Immunology. ; Cancer Biology. ; Computational and Systems Biology. ; Immunology.
    Description / Table of Contents: 1. Introduction: Introduction of lipids, lipid metabolism and tumor immunity -- 2. ipid metabolism and lipidomics -- 3. Applications of lipidomics in tumour immunity.-4. Overview: Lipid metabolism in tumour microenvironment -- 5. Lipid metabolism in cancer cells -- 6. Lipid metabolism in tumour-associated NK -- 7. Lipid metabolism in tumour-associated macrophages -- 8. Lipid metabolism in tumour-associated MDSCs -- 9. Lipid metabolism in tumour-associated fibroblasts -- 10. Lipid metabolism in tumour-associated B cells -- 11. Lipid metabolism in tumour-infiltrating T cells -- 12. Lipid metabolism and angiogenesis -- 13. Lipid metabolism and tumor antigen-presenting -- 14. Lipid metabolism and immune checkpoints.
    Abstract: This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery. .
    Type of Medium: Online Resource
    Pages: XI, 211 p. 24 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813367852
    Series Statement: Advances in Experimental Medicine and Biology, 1316
    DDC: 571.978
    Language: English
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  • 43
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Human physiology. ; Radiology. ; Diseases. ; Bioinformatics. ; Immunology. ; Human Physiology. ; Radiology. ; Diseases. ; Computational and Systems Biology. ; Immunology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. The Economics of Obesity-A Public Policy Perspective -- Chapter 3. Obesity and skin problems -- Chapter 4. Obesity and endometriosis -- Chapter 5. Hypogonadism -- Chapter 6. Effect of obesity in cardiovascular system -- Chapter 7. Impact of obesity on vaccination -- Chapter 8. Obesity-linked diseases (Comorbidities) -- Chapter 9. Imaging as a tool for measuring body fat -- Chapter 10. Extrapolation from clinical trial to practice: current pharmacotherapy on obesity -- Chapter 11. Nanotechnology in the context of obesity -- Chapter 12. Computational approach in drug development for obesity.
    Abstract: This book summarizes the effects of obesity on health and its correlation with a wide range of debilitating and life-threatening conditions in humans. It discusses the possible pathological mechanisms that are involved in the development of obesity and highlights obesity-associated molecular mechanisms that contribute to reproductive dysfunctions in men and women. The book provides mechanistic insights on the role of obesity in cardiovascular and respiratory disorders, and examines the role of the complementary molecular mechanism of the gut microbiota in the development of obesity. It also reviews the interaction between the metabolic system and immune cells in the pathogenesis of obesity-associated diseases. Lastly, it assesses the latest advances in nanomedicine as an emerging strategy for the treatment of obesity.
    Type of Medium: Online Resource
    Pages: XVI, 181 p. 13 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813364080
    DDC: 612
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Proteins . ; Cytology. ; Biomedical Research. ; Protein Biochemistry. ; Cell Biology.
    Description / Table of Contents: Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and Cancer Immunotherapy -- Chaperonin Hsp60 and Cancer Therapies -- Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment -- Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Therapeutics -- Multifaceted Roles of Heat Shock Factor 1 (HSF1) in Cancer -- Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer -- Heat Shock Proteins in Atrial Fibrillation -- Threading Microarrays into Novel Applications -- Regulation of Kaposi’s Sarcoma-associated Herpesvirus Biology by Host Molecular Chaperones -- Role of Heat Shock Factors in Diseases and Immunity -- Heat Shock Proteins and Pain -- Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway -- Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with diverse Cellular and Molecular Functions -- Roles of Heat Shock Proteins on Antigen Presentation -- Heat shock proteins mediate anastasis and plasticity of thermotolerant cells.
    Abstract: The book Heat Shock Proteins in Human Diseases provides the most comprehensive review on contemporary knowledge on the role of heat shock proteins (HSP) in various types of human diseases including cancer, cardiovascular disease, microbiology and inflammation. These diseases were specifically chosen due to their dismal prognosis, the survival benefit offered by the current standards do not greatly impact the overall survival statistics with the disease and are associated with toxicity. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in human diseases. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 297 p. 31 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030622893
    Series Statement: Heat Shock Proteins, 21
    DDC: 610.72
    Language: English
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  • 45
    Online Resource
    Online Resource
    Tokyo :Springer Japan :
    Keywords: Urban ecology (Biology). ; Landscape architecture. ; Human geography. ; Landscape ecology. ; Civil engineering. ; Sustainability. ; Urban Ecology. ; Landscape Architecture. ; Human Geography. ; Landscape Ecology. ; Civil Engineering. ; Sustainability.
    Description / Table of Contents: PART I Chapter 1 Approach For Ecological Landscape And Urban Biodiversity -- Chapter 2 Diversity And Design On A Former Freight Rail-Yard -- Chapter 3 Biodiversity In The Day To Day Practice Of The Landscape Architect -- Chapter 4 Edible Landscapes: Relocalising Food And Bringing Nature Into North London -- Chapter 5 Landscape Design For Nature Restoration And In Urban Areas In Japan -Planning Process Of Designing A River Bank Fishway And Surroundings- -- PART II Chapter 6 Nature In The Cities - Places For Play And Learning -- Chapter 7 Greening School Grounds: Schools’ Role In A Biodiversity Process -- Chapter 8 Nature Environment And Management For Children’S Play And Learning In Kindergarten In Urban Forest, Kyoto, Japan -- Chapter 9 Ecological Evaluation Of Landscape Components Of The Tokushima Central Park Through Red-Clawed Crab (Chiromantes Haematocheir) -- Chapter 10 Developing Urban Green Spaces And Effective Use Of Rooftop Spaces For Cooling And Urban Biodiversity -- PART III Chapter 11 Addressing Climate Change And Biodiversity Loss From An Urban Perspective: Linking Climate Co-Benefits And Urban Ecosystem Services In Sao Paulo City, Brazil -- Chapter 12 Evaluation Of Habitat Functions Of Fragmented Urban Forests For Wildlife ~ The Case Of Kitakyushu City -- Chapter 13 The Effects And Functions Of Spatial And Structural Characteristics Of Shrine Forests As Urban Green Space -- Chapter 14 Green Infrastructure As A Planning Response To Urban Warming A Case Study Of Taipei Metropolis -- Chapter 15 Green Infrastructure Planning For Asian Cities: The Planning Strategies, Guidelines, And Recommendations.
    Abstract: This book highlights various designs for urban green spaces and their functions. It provides an interesting meeting point between Asian, European and North America specialists (researchers, planners, landscape architects) studying urban biodiversity; urban biodiversity and green space; relations between people and biodiversity. The most important feature of this book is the unique point of view from each contributor towards “the relationship between nature and people in urban areas”, in the context of the ecosystem and biodiversity in urban areas and how to manage them. All chapters explore and consider the relationship between humans and nature in cities, a subject which is taking on increasing importance as new cities are conceptualized and planned. These discussion and examples would be useful for urban ecology researchers, biologists, city planners, government staff working in city planning, architects, landscape architects, and university instructors. This book can also be used as a textbook for undergraduate and postgraduate city planning, architecture or landscape architecture courses. .
    Type of Medium: Online Resource
    Pages: X, 375 p. 196 illus., 134 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9784431568568
    DDC: 577.56
    Language: English
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  • 46
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plants Evolution. ; Plants Development. ; Plant ecology. ; Plant biotechnology. ; Plant diseases. ; Plant Evolution. ; Plant Development. ; Plant Ecology. ; Plant Biotechnology. ; Plant Pathology.
    Description / Table of Contents: Preface -- Afghanistan -- Azerbaijan -- Bangladesh -- Bhutan -- Brunei Darussalam -- Cambodia -- China -- Cyprus -- India -- Indonesia -- Iran -- Iraq -- Israel -- Japan -- Jordan -- Korean -- Kyrgyzstan -- Laos -- Lebanon -- Malaysia -- Mauritius -- Myanmar. -Nepal -- Pakistan -- Palestine -- Philippines -- Russia -- Saudi Arabia -- Singapore -- South Korea -- Sri Lanka -- Taiwan -- Tajikistan -- Thailand -- Turkey -- Uzbekistan -- Vietnam -- Index.
    Abstract: Natural resources and associated biological diversity provide the basis of livelihood for human population, particularly in the rural areas and mountain regions across the globe. Asia is home to the world's highest mountain regions including the Himalayas, Karakorum and Hindukush. These regions are renowned around the globe because of their unique beauty, climate, and biocultural diversity. Because of geoclimatic conditions, the mountains of Asia are medicinal and food plant diversity hot spots. The indigenous communities residing in the valleys of these mountains have their own culture and traditions, and have a long history of interaction with the surrounding plant diversity. Local inhabitants of these mountains areas possess significant traditional knowledge of plant species used as food, medicine, and for cultural purposes. So far, many workers have reported traditional uses of plant species from different regions of Asia including some mountain areas; however, there is not one inclusive document on the ethnobotany of mountains in Asia. This book provides a comprehensive overview on ethno-ecological knowledge and cross cultural variation in the application of plant species among various communities residing in the mountains of Asia; cross cultural variation in traditional uses of plant species by the mountain communities; high value medicinal and food plant species; and threats and conservation status of plant species and traditional knowledge. This book should be useful to researchers of biodiversity and conservation, ethnobiologists, ethnoecologists, naturalists, phytochemists, pharmacists, policy makers, and all who have a devotion to nature.
    Type of Medium: Online Resource
    Pages: XIV, 439 p. 152 illus., 148 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030554941
    Series Statement: Ethnobiology,
    DDC: 581.38
    Language: English
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    Keywords: Pharmacology. ; Medical genetics. ; Pathology. ; Pharmacology. ; Clinical Genetics. ; Pathology.
    Description / Table of Contents: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.
    Abstract: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
    Type of Medium: Online Resource
    Pages: VIII, 323 p. 70 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030700638
    Series Statement: Handbook of Experimental Pharmacology, 265
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Immunology. ; Medical sciences. ; Cytology. ; Biochemistry. ; Nutrition   . ; Immunology. ; Health Sciences. ; Cell Biology. ; Biochemistry. ; Nutrition.
    Description / Table of Contents: Prelims -- One-carbon metabolism and development of the conceptus during pregnancy: Lessons from studies with sheep and pigs -- Cell-specific expression of enzymes for serine biosynthesis and glutaminolysis in farm animals -- Amino acids in beef cattle nutrition and production (author to be identified) -- Amino acid nutrition and reproductive performance in ruminants -- Amino acids in the nutrition and production of sheep and goats -- Amino acids in swine nutrition and production -- Amino acid nutrition and metabolism in chickens -- Nutrition and functions of amino acids in fish -- Nutrition and functions of amino acids in aquatic crustaceans -- Amino acids in dog nutrition and health -- Amino acids in the nutrition, metabolism, and health of domestic cats -- Amino acid nutrition for optimum growth, development, reproduction, and health of zoo animals.
    Abstract: This edited volume comprehensively highlights recent advances in the metabolism, nutrition, physiology, and pathobiology of amino acids in companion (dogs and cats), zoo (carnivores, herbivores, and omnivores), and farm (including cattle, pigs, sheep, goats, chickens, fish, and crustaceans) animals. It enables readers to understand the crucial roles of amino acids and their metabolites in the growth, development, health, and metabolic diseases of these animals. Readers will learn from well-written chapters that amino acids are not only the building blocks of protein but are also signaling molecules and key regulators of gene expression and whole body homeostasis in companion, domestic, aquatic, and captive animals. The book also provides new and useful information on the optimum requirements of the animals for dietary amino acids. This knowledge will guide nutritional practices and daily management to improve the health and survival of all species and to enhance the productivity of livestock, poultry, and aquaculture enterprises worldwide to produce high-quality protein for human consumption. Editor of this volume is an internationally recognized expert in the biochemistry, nutrition and physiology of amino acids. He has over 38 years of experience with research and teaching at world-class universities in the area of amino acid biochemistry, nutrition, and physiology. He has published more than 625 papers in peer-reviewed journals, 62 chapters in books, and authored two text/reference books, with an H-index of 117 and more than 55,000 citations in Google Scholar. This publication is a useful reference for professionals and pet owners, as well as undergraduate and graduate students in animal science, aquaculture, zoology, wildlife, veterinary medicine, biology, biochemistry, food science, nutrition, pharmacology, physiology, toxicology, and other related disciplines. In addition, all chapters provide general and specific references to amino acid nutrition and metabolism for researchers and practitioners in animal agriculture, aquaculture, zoos, biomedicine, and plant science, and for government policy makers. Chapter 7 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VI, 256 p. 36 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030544621
    Series Statement: Advances in Experimental Medicine and Biology, 1285
    DDC: 571.96
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant biotechnology. ; Plant genetics. ; Agriculture. ; Plant Biotechnology. ; Plant Genetics. ; Agriculture.
    Description / Table of Contents: Preface -- Mango: The King of Fruits -- Botanical descriptions -- Propagation practices -- Germplasm and genetic resources -- Genetic diversity analysis -- Alternate flowering -- Classical genetics and breeding -- In Vitro Culture and genetic transformation -- Molecular mapping and breeding in mango -- Genome sequence -- Sequencing of organellar genomes -- Functional genomics -- Genomic resources and database.
    Abstract: This book represents the first comprehensive compilation of deliberations on botany; genetic resources; genetic diversity analysis; classical genetics & traditional breeding; in vitro culture & genetic transformation; detailed information on molecular maps & mapping of economic genes and QTLs; whole genome sequencing of the nuclear genome and sequencing of chloroplast genome; and elucidation of functional genomics. It also addresses alternate flowering, a unique problem in mango, and discusses currently available genomic resources and databases. Gathering contributions by globally reputed experts, the book will benefit the students, teachers, and scientists in academia and at private companies interested in horticulture, genetics, breeding, pathology, entomology, physiology, molecular genetics and breeding, in vitro culture & genetic engineering, and structural and functional genomics.
    Type of Medium: Online Resource
    Pages: XXVIII, 228 p. 41 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030478292
    Series Statement: Compendium of Plant Genomes,
    DDC: 631.52
    Language: English
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  • 50
    Keywords: Botanical chemistry. ; Alternative medicine. ; Biotechnology. ; Agricultural biotechnology. ; Biomaterials. ; Food science. ; Plant Biochemistry. ; Complementary and Alternative Medicine. ; Biotechnology. ; Agricultural Biotechnology. ; Plant Materials. ; Food Engineering.
    Abstract: Before the concept of history began, humans undoubtedly acquired life benefits by discovering medicinal and aromatic plants (MAPs) that were food and medicine. Today, a variety of available herbs and spices are used and enjoyed throughout the world and continue to promote good health. The international market is also quite welcoming for MAPs and essential oils. The increasing environment and nature conscious buyers encourage producers to produce high quality essential oils. These consumer choices lead to growing preference for organic and herbal based products in the world market. As the benefits of medicinal and aromatic plants are recognized, these plants will have a special role for humans in the future. Until last century, the production of botanicals relies to a large degree on wild-collection. However, the increasing commercial collection, largely unmonitored trade, and habitat loss lead to an incomparably growing pressure on plant populations in the wild. Therefore, medicinal and aromatic plants are of high priority for conservation. Given the above, we bring forth a comprehensive volume, “Medicinal and Aromatic Plants: Healthcare and Industrial Applications”, highlighting the various healthcare, industrial and pharmaceutical applications that are being used on these immensely important MAPs and its future prospects. This collection of chapters from the different areas dealing with MAPs caters to the need of all those who are working or have interest in the above topic.
    Type of Medium: Online Resource
    Pages: XIV, 783 p. 10 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030589752
    DDC: 572.2
    Language: English
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    Keywords: Ecology . ; Agriculture. ; Zoology. ; Veterinary medicine. ; Epidemiology. ; Ecology. ; Agriculture. ; Zoology. ; Veterinary Science. ; Epidemiology.
    Description / Table of Contents: Part 1 Introduction -- 1 Host Community Interfaces: The Wildlife-Livestock -- 2 Natural And Historical Overview Of The Animal Wildlife-Livestock Interface -- 3 The Ecology Of Pathogens Transmission At The Wildlife-Livestock Interface: Beyond Disease Ecology, Towards Socio-Ecological System Health -- Part 2 Regional Perspectives Of Disease At The Wildlife-Livestock Interface -- 4 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In Europe -- 5 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In Asia -- 6 Characteristics And Perspectives Of Disease At Wildlife-Livestock Interface In Africa -- 7 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In Oceania -- 8 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In North America -- 9 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In Central And South America -- Part 3 Characterization Of The Wildlife-Livestock Interface -- 10 Collecting Data To Assess The Interactions Between Livestock And Wildlife -- 11 Characterization Of Wildlife-Livestock Interfaces: The Need For Interdisciplinary Approaches And A Dedicated Thematic Field -- 12 Quantifying Transmission Between Wild And Domestic Populations -- Part 4 Synthesis And Conclusions -- 13 Synthesis And Future Perspectives Of The Study And Management Of Diseases At The Wildlife-Livestock Interface.
    Abstract: Shared diseases among wildlife, livestock and humans, often transboundary, are relevant to public health and global economy, as being highlighted currently relative to the global COVID19 pandemic. Diseases at these interfaces also impact the conservation of biodiversity and must be considered when managing wildlife. While wildlife and domestic livestock have coexisted in dynamic systems for thousands of years, spillover disease risks are higher today than in the past due to global patterns of increasing close contact and interactions among wildlife, livestock and humans in the context of complex, diverse and numerous circumstances. Multidisciplinary studies of animal interfaces, especially those involving wildlife, therefore, must be brought to the forefront so that knowledge gaps can be realized and filled to inform managers and policy makers. In the first part of the book authors illustrate and discuss ecological and epidemiological concepts related to the interfaces, with a vision towards socio-ecological system health. In addition, the history of past animal interfaces provides the necessary perspective to focus current questions, better understand present situations, and informs how we can best approach the future. The second part discusses the myriad of similar and differing wildlife- livestock interfaces found around the world from a regional point of view. The third part focuses on how to assess the spatial and temporal overlap between livestock and wildlife, and authors present new technical innovations about how inter-transmissions between wild and domestic populations can be quantified. An overview of main modeling approaches available to quantify multi-host disease transmission at the wildlife/livestock interface, illustrated with specific-case studies, is also presented. Finally, the need for interdisciplinary approaches and a dedicated thematic field to approach the wildlife/livestock interfaces and create opportunities to promote wildlife–livestock coexistence is emphasized. The concluding chapter presents perspectives and directions to better understanding disease dynamics at the wildlife/livestock interface, global change and implications for the future. The changing distribution of interfaces, ongoing human and environmental changes (e. g. climate warming, changes in animal production systems, etc.) and their likely impacts and consequences for the interfaces and disease transmission processes are all discussed.
    Type of Medium: Online Resource
    Pages: XVI, 421 p. 77 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030653651
    Series Statement: Wildlife Research Monographs, 3
    DDC: 577
    Language: English
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  • 52
    Keywords: Agricultural biotechnology. ; Nanobiotechnology. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Agricultural Biotechnology. ; Nanobiotechnology. ; Environmental Engineering/Biotechnology.
    Description / Table of Contents: Preface -- Biobased Nanotechnology for Green Applications -- Characterization and Biocompatibility of a Poly Lactic Acid (PLA) 3D-Printed Scaffold -- Implications of Nanoscopic Surface Modification on Protein Adsorption and Cell Adhesion -- Biosurfactant-Based Nanoscale Micelles Extraction of Bio-Molecules -- Nanoemulsion of Herbal Bioactives -- Current Aspects of Nanotechnology in Agriculture -- Novel Strategies for Environmental Remediation of Pesticides Using Nano-Catalysts -- Bio-Nanoconjugates for Their Potential Role in Medical Science and Pharmaceuticals -- Enzymes in Nanoemulsion: A Way Forward for the Bioremediation of Organopollutants -- Biochar-Based Nanocomposites: A Sustainable Solution for Wastewater Treatment -- Bacteriocins as Nanoparticle Forms and Their Applications -- Dry Deposition of Atmospheric Nanoparticles -- Carbon Dots and Their Theranostic Applications -- Magnetic Nanoparticlles from Bacteria -- Exploring the Protective Efforts of Silver Nanoparticles as Bionanofungicide Against Soil-Borne Sclerotium rolfsii Infection in Wheat Plants -- A Green Synthetic of Magnetite Nanoparticles to Treat Heavy Metal Stress in Oryza sativa L. -- Synthesis of Novel Metal/Metal Oxide-Based Nanomaterials Using Plant Sources and Their Potential Environmental Applications -- Structural Model and Diagram Electro-Magnetoelastic Actuator for Nanobiotechnology -- Bionanocomposites for Green Applications -- Importance of Nanotechnologies in Changing Climatic Conditions -- Nanotechnology for Biofuels: Progress and Pitfalls -- Metal Organic Framework Nanomaterials -- Nanobubble Liposome Complexes: Significance in Diagnostic Imaging and Ultrasound-Triggered Drug Delivery -- Benefits of Chitosan-Based and Cellulose-Based Nanocomposites in Food Protection and Food Packaging -- Index.
    Abstract: Investigation on biobased nanomaterials has provided new insights into the rapidly advancing fields of the biomedical and environmental sciences by showing how these nanomaterials are effective in biomedicine and environmental remediation. These particles hold tremendous prospective applications, and are likely to become the next generation of particles in these areas. As such, research is ongoing and the data generated should have the potential for a sustainable future in both the environmental and biomedical fields. This book presents important findings on the role of and identification of novel applications of biobased nanomaterials. Unlike other books in this field, this book focuses entirely on sustainable application and remediation in biomedicine and environmental science. The chapters are written in such a way as to make them accessible to the reader, and furthermore, the volume can be readily adopted as a reference, or used as a guide for further research. This project was based on recent research (the last 5 years) and developed through an extensive literature search. The editors have also compiled some advanced, outstanding texts that should be of benefit to graduate students in their research.
    Type of Medium: Online Resource
    Pages: XX, 668 p. 89 illus., 66 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030619855
    Series Statement: Nanotechnology in the Life Sciences,
    DDC: 630
    Language: English
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  • 53
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Drug delivery systems. ; Regenerative medicine. ; Biomedical Research. ; Pharmacology. ; Drug Delivery. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Approaches Towards Synthetic Signal Transduction in Phospholipid Bilayers -- Development of Novel Versatile Theranostic Platforms Based on Titanate Nanotubes: Towards Safe Nanocarriers for Biomedical Applications -- Metal-organic Framework—Polymer Mixed-Matrix Membranes -- Insights into Adaptive Selforganized Supramolecular Structures from Molecular Modeling and Visualization -- Self-Assembled Metallacages as Drug Delivery Systems: Design Concepts and Challenge -- Functional Microporous Polymer Networks: Synthesis and Applications -- A Story on Carbon Dioxide and its Hydration -- Inverse Design and Hierarchical Multiscale Modelling of Biological Matter -- DNA-Directed Self-assembly of Macromolecular Structures -- Luminescent Complexes and their Assemblies : from Understanding to Artificial Virus -- Tailor-Made Polymers and Nanoparticles for Applications in Nanomedicine -- Squalene-based Nanomedicines : An Original and Efficient Approach for the Treatment of Neurological Disorders without Crossing the Blood-Brain Barrier -- Biodegradable Nanoparticles for Specific Drug Transport -- Multivalent rotaxanes designed as antibiofilm agents -- Measuring Ionic Transport through Lipid Bilayers -- Polymeric Carriers for Transporting Nucleic Acids - Contributions to the Field -- Smart Polymeric Materials for Drug Delivery -- Supramolecular Guanosine-quadruplex Hydrogels and Hydrogel Composites for Cell Growth Applications -- Hydrogelation of Chitosan with Monoaldehydes towards Biomaterials with Tuned Properties -- Inorganic Nanoarticles as Free Radical Scavengers -- A Microbiological Epilogue - Nosocomial Infections -- Molecular Dynamic Simulations and In Silico Analysis of Supramolecular Self-Assembled Structures -- Validation of the Non Toxicity of Non Viral Genetic -- Kinetics Transport of Ions/Water Through Nano-Scale Channels : Review And Update.
    Abstract: This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations. The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to treat the disease. Another interest concerns new ways to administer gene therapy. If genes are often delivered to their target cells by adapted viruses, the supramolecular non-viral ‘vectors’ using dynamic nano-frameworks and nano-structures are presented. In addition, it is important to reconstruct damaged tissues by mimicking natural processes in cells and polymers, such as tissue engineering and self-healing. Different options are here discussed: e.g. hydrogels based on chitosan, a carbohydrate polymer, are proving especially promising for tissue engineering and drug delivery. For controlled delivery of drugs or other biologically active compounds, hydrogels sensitive to the most important stimuli in the human body, such as temperature, pH, ionic strength, glucose and biomolecules released by the organism in pathological conditions have been developed. Finally, to assist and validate the experimental studies, computer modelling and simulations of large-sized molecular structures and systems using different molecular dynamics and quantum mechanical techniques are developed based on the experimental and chemistry synthesis. This book is of great interest for graduate students, researchers and health professionals interested in acquiring a better understanding of the mechanisms of medical treatments. In addition, it provides numerous tools to develop better therapies for human diseases.
    Type of Medium: Online Resource
    Pages: XII, 371 p. 174 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030574567
    DDC: 610.72
    Language: English
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    Keywords: Regenerative medicine. ; Stem cells. ; Nervous system Regeneration. ; Biomaterials. ; Cells. ; Regenerative Medicine and Tissue Engineering. ; Stem Cell Biology. ; Regeneration and Repair in the Nervous System. ; Biomaterials-Cells.
    Description / Table of Contents: Chapter 1. Regeneration and tissue microenvironment -- Chapter 2. Non stem cell mediated tissue regeneration and repair -- Chapter 3. Immunological Perspectives Involved in Tissue Engineering -- Chapter 4. Advances in Medical Imaging for Wound Repair and Regenerative Medicine -- Chapter 5. Role of Biosensors in Regenerative Therapeutics: Past, Present & Future Prospects -- Chapter 6. Acute and Chronic Wound Management: Assessment, Therapy and Monitoring Strategies -- Chapter 7. Stem cells and therapies in cardiac regeneration -- Chapter 8. Hydrogel-based Tissue-mimics for Vascular Regeneration and Tumor Angiogenesis -- Chapter 9. Advances in 3D Printing Technology for Tissue Engineering -- Chapter 10. Adult Neurogenesis: A Potential Target for Regenerative Medicine -- Chapter 11. Regenerative approaches in the nervous system -- Chapter 12. Prenatal interventions for the treatment of congenital disorders -- Chapter 13. Understanding LncRNAs in biomaterials development for osteointegration -- Chapter 14. Current approaches in vertical bone augmentation and large bone deficiencies in the oro-facial region -- Chapter 15. In-vitro and in-vivo tracking of cell-biomaterial interaction to monitor the process of bone regeneration -- Chapter 16. The Prospects of RNAs and Common Significant Pathways in Cancer Therapy and Regenerative Medicine.
    Abstract: This book focuses on the recent innovations and therapeutic potentials of regenerative medicine and discusses the applications of stem cells, biomaterials, and tissue engineering in regenerative medicine. The book covers essential aspects of regenerative medicine, including tissue microenvironment, immunological perspectives, stem, and non-stem cell-mediated approaches, imaging techniques, biomarkers, and 3D printing technology. It also reviews the applications of biosensing technologies in regenerative medicine, including biomanufacturing, organ-on-a-chip technologies, and as indicators of therapeutic efficacy. Further, it focuses on the regenerative medicine approaches for diseases of the central nervous system. It also provides the therapeutic potential of regenerative medicine to improve soft tissue and wound healing, cardiovascular, neural, bone, and orofacial regeneration.
    Type of Medium: Online Resource
    Pages: XV, 390 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811960086
    DDC: 612.028
    Language: English
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  • 55
    Keywords: Biodiversity. ; Biotic communities. ; Conservation biology. ; Ecology . ; Vertebrates. ; Invertebrates. ; Biodiversity. ; Ecosystems. ; Conservation Biology. ; Vertebrate Zoology. ; Invertebrate Zoology.
    Description / Table of Contents: 1.1 General Introduction Principal -- 2. Zoloogical Groups -- 2.1 Arachnids -- 2.2 Insects: Migrants, endemics, and old to new pests -- 2.3 Freshwater decapod crustaceans: the challenges of documenting and preserving a very diverse fauna -- 2.4 Mexican molluscs: In the process of a 'silent extinction' -- 2.5 Amphibians and reptiles -- 2.6 Anthropocene impacts on the Mexican freshwater fish fauna -- 2.7 Mexican avifaunas of the Anthropocene -- 2.8 Marine birds -- 2.9 Terrestrial mammals -- 2.10 Marine mammals -- 2.11Mexican bats: conservation challenges in the Anthropocene -- 3. Ecosytems -- 3.1 The impact of the growth of urban environments on Mexican fauna -- 3.2 Anchialine fauna of the Yucatan Peninsula -- 3.3 Semi-terrestrial and aquatic invertebrates and fish in mangroves in México -- 3.4 Defaunation of Mexican tropical forests3.5 Mezcal boom and extinction debts in Mexican arid ecosystems -- 3.6 Deep sea life -- 3.7 The importance of agroecosystems for the Mexican fauna -- 3.8 The salamanders of the Mexican cloud forest -- 3.9 Human effects on caves in Mexico -- 3.10 Fauna of lakes and rivers -- 3.11 Coral reef faunal assemblages in the Mexican Caribbean: assessing the cryptic biodiversity -- 4 Processes -- 4.1 Contemporary climate change impacts on Mexican fauna -- 4.2 Invasive alien species of invertebrates and fishes introduced to Mexican freshwater systems -- 4.3 Are marine fisheries sustainable? -- 4.4 Pest dynamics in Mexican forests -- 4.5 Pollination by wild and managed animal vectors -- 4.6 Social participation strategies for the conservation of Mexican fauna -- 4.7 Citizen science for deep ocean biodiversity: a crowdsourcing tool in support of conservation -- 4.8 Legal actions for the conservation of fauna.
    Abstract: This contributed volume presents an analysis of the current conservation status of major faunal groups in Mexico. The chapters describe a prognosis of future challenges, and also explore the expanding threats inherent in the Anthropocene within the context of the unique physical, biological and cultural aspects of the nation. Covering 27 chapters, and written by Mexican and international authors, this book analyzes a wide range of vertebrate and invertebrate animal taxa, their ecosystems and the critical processes related to their present conservation status. This volume is an important reference material for researchers, conservationists and students interested in the biological and ecological processes shaping the Mexican fauna.
    Type of Medium: Online Resource
    Pages: XVII, 597 p. 50 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031172779
    DDC: 333.95
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Water. ; Hydrology. ; Biotic communities. ; Social sciences. ; Humanities. ; Environmental management. ; Freshwater and Marine Ecology. ; Water. ; Ecosystems. ; Humanities and Social Sciences. ; Environmental Management.
    Description / Table of Contents: Part I. Introduction -- Chapter 1. Southern Baltic Coastal Systems Analysis: Questions, Conceptions and Red Threads -- Chapter 2. Coastal Ecosystems from a Social-Ecological Perspective -- Part II. Ecological Structures and Functions of the German Baltic Sea Coast -- Chapter 3. The Abiotic Background: Climatic, Hydrological and Geological Conditions of the Southern Baltic -- Chapter 4. Geological and Sedimentary Conditions -- Chapter 5. Environmental Conditions at the Coast: The Terrestrial Ecosystems -- Chapter 6. Environmental Conditions at the Coast: Shoreline Ecosystems -- Chapter 7. Ecosystem and Landscape Functions of the Coast: Recent Research Results -- Chapter 8: Benthic Habitats and Their Inhabitants -- Part III. Ecological Structures and Functions of Coastal Water and Offshore Ecosystems -- Chapter 9. Introducing the Ecological Aspects -- Chapter 10. Baltic Sea Aquatic Ecosystems in a Gradient from Land to Open Sea -- Chapter 11. Comparison of Abiotic Parameters and Dominant Primary Producers Between the Two Main Investigation Areas -- Chapter 12. Short-Term Variability, Long-Term Trends and Seasonal Aspects in the Darß-Zingst Bodden Chain -- Chapter 13. Carbon Fluxes/Food-Webs: Effect of Macrophytes on Food Web Characteristics in Coastal Lagoons -- Chapter 14. Ecological Structure in Benthic Habitats of Offshore Waters -- Chapter 15. Patterns of Bioturbation and Associated Matter Fluxes -- Chapter 16. Seasonal Aspects and Short-Term Variability of the Pelagic Offshore Ecosystems -- Chapter 17. Long-Term Trends of the Offshore Ecosystems -- Chapter 18. Nutrient and Limitation Regimes in Coastal Water Ecosystems -- Part IV. Combining the Aspects: Ecosystem Service Assessment -- Chapter 19. The Human Factor: Coastal Social-Ecological Systems -- Chapter 20. Introduction: The Concept of Ecosystem Service Assessment Applied to Coastal Systems -- Chapter 21. The Missing Links in Ecosystem Service Research -- Chapter 22. Eudaimonic Valuation of Cultural Ecosystem Services -- Chapter 23. Economic Valuation of Cultural Ecosystem Services -- Chapter 24. Spatial Ecosystem Service Assessment Across the Land-Sea-Interface -- Chapter 25. Temporal Changes in Aquatic Ecosystem Services Provision: Approach and Examples -- Chapter 26. Assessing Temporal Changes in Ecosystem Service Provisions: Conceiving Future Pathways -- Part V. Synthesis: Assessment as a Tool for Managing Coastal Ecosystems? -- Chapter 27. Applying the Integrated Approach -- Chapter 28. Mechanisms of Ecosystem Service Production: An Outcome of Ecosystem Functions and Ecological Integrity in Coastal Lagoons -- Chapter 29. Ecosystem Service Assessment in European Coastal and Marine Policies -- Chapter 30. Ecosystem Services and Sustainable Development: The Case for Strong Sustainability -- Chapter 31. Concluding Remarks.
    Abstract: This book gives an overall analysis of the current knowledge status about structures, functions, utilization for German Baltic coast ecosystems. The main focus of this book is on the aquatic area, but land/sea interactions as well as river outfalls are included as well. Characteristic for this book is the inclusion of social science aspects. Approximately one third of its extent will be about the ecosystem services. In this segment the results of the last 6 years are presented in which a comprehensive quantification of the social relevance of ecosystems was carried out covering the entire area of the German Baltic Sea. This part builds directly on the results of scientific investigations and are in relation to social ideals. The assessment will not only be economically and ethically but also the mechanisms that are used for the valorisation of the ecosystem services will be evaluated. Both sub-areas, the classic natural science part as well as the part of social science aspects, deal with the changes caused by increasing anthropogenic influence and social (including demographic) changes. This will be among others in the sense of an exemplary historical outline. The final chapter of the synthesis therefore not only presents a summary of the level of knowledge gained and a deduction of the research needs. It further contains a presentation of the application aspects resulting from the analysis of the social relevance gained from basic scientific research. The book is aimed at scientists (and students) of natural, life and social sciences, analysing functioning and structures of coastal ecosystems with regard to sustainable use and nature protection, including aspects of coastal protection. Besides, it is thought to become a reference for all levels of decision makers and stakeholders in coastal and marine management of the Baltic and North Sea region, providing also a blueprint for system analysis respecting for societal as well as biological aspects world-wide.
    Type of Medium: Online Resource
    Pages: XV, 387 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031136825
    Series Statement: Ecological Studies, Analysis and Synthesis, 246
    DDC: 577.6
    Language: English
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  • 57
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Human physiology. ; Neurology . ; Life sciences. ; Physiology. ; Neuroscience. ; Human Physiology. ; Neurology. ; Life Sciences. ; Animal Physiology. ; Life Sciences.
    Description / Table of Contents: Part I: HISTORY -- Chapter 1: Transmissible Spongiform Encephalopathy: from its beginnings to Daniel Carleton Gajdusek -- Part II: GENERAL ASPECTS OF PRIONS -- Chapter 2: The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein -- Chapter 3: Mammalian Prion Structures -- Chapter 4: Insoluble Cellular Prion Protein and Other Neurodegeneration-related Misfolded Protein Aggregates in the Brain of Asymptomatic Individuals -- Part III: CONVERSION AND STRAIN OF PRIONS -- Chapter 5: Prion Conversion and Deformed Templating -- Chapter 6: Prion Strain Interference -- Chapter 7: Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins -- Chapter 8: Cofactor Involvement in Prion Propagation -- Chapter 9: Prion Protein Conversion and Lipids -- Part IV: ENVIRONMENT AND TRANSMISSION OF PRIONS -- Chapter 10: Prions in the Environment -- Chapter 11: Environmentally Acquired Transmissible Spongiform Encephalopathy -- Chapter 12: Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion -- Chapter 13: Species Barriers in Prion Disease -- Part V: MODELLING OF PRIONS -- Chapter 14: Modeling the Cell Biology of Prions -- Chapter 15: Transgenic Mice Modelling in Prion Diseases -- Chapter 16: Stem Cell Models in Prion Research -- Chapter 17: Drosophila Models of Prion Diseases -- Part VI: HUMAN PRION DISEASES AND OTHER PATHOLOGIES -- Chapter 18: Human Sporadic Prion Diseases -- Chapter 19 Genetic Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker Diseases -- Chapter 20: Glycoform-selective Prions in Sporadic and Inherited Variably Protease-sensitive Prionopathies -- Chapter 21: The Spectrum of Tau Pathology in Human Prion Disease -- Chapter 22: Prion Protein Complex with mGluR5 Mediates Amyloid-ß Synaptic Loss in Alzheimer’s Disease -- Chapter 23: Prion and Cancers -- Chapter 24: Protective Role of Cellular Prion Protein in Tissue Ischemic/Reperfusion Injury -- Part VII: ANIMAL PRION DISEASES -- Chapter 25: Bovine Spongiform Encephalopathy -- Chapter 26: Classical and Atypical Scrapie in Sheep and Goats -- Chapter 27: Research models for studying chronic wasting disease -- Part VIII: YEAST PRIONS -- Chapter 28: Introduction to Yeast and Fungal Prions -- Chapter 29: Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems -- Part IX: DIAGNOSIS AND HUMAN PRION SURVEILLANCE -- Chapter 30: Real-time quaking-induced conversion (QuIC) assays for the detection and diagnosis of human prion diseases -- Chapter 31: Protein Misfolding Cyclic Amplification -- Chapter 32: Skin Misfolded Proteins as Biomarkers for Diagnosis of Prion and Prion-like Diseases -- Chapter 33: Diagnosis of Prion Disease: Conventional Approaches -- Chapter 34: Human Prion Disease Surveillance -- Part X: TREATMENT -- Chapter 35: Overview on Treatment of Prion Diseases and Decontamination of Prions -- Chapter 36: Gene Therapy Strategies for Prophylactic and Therapeutic Treatments of Human Prion Diseases -- Chapter 37: Immunomodulation.
    Abstract: Transmissible spongiform encephalopathies (TSE), now known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains the most authoritative views about the past, present, and future of prions and prion diseases covering fresh perspectives on important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
    Type of Medium: Online Resource
    Pages: XII, 793 p. 81 illus., 62 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031205651
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Regenerative medicine. ; Medicine Research. ; Biology Research. ; Genetics. ; Epigenetics. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Genetics. ; Epigenetics.
    Description / Table of Contents: Chapter 1. Genetics and Epigenetics of Ageing and Age Associated Diseases -- Chapter 2. Coenzyme Q as an anti aging strategy -- Chapter 3. Autophagy as a Promising Therapeutic Target in Age-Associated Neurodegenerative Disorders -- Chapter 4. Glycolytic inhibitors as Caloric Restriction Mimetics (CRM) -- Chapter 5. Anti-aging and rejuvenation based on stem cell therapy -- Chapter 6. Novel strategies for metformin as an anti-aging drug in skin aging -- Chapter 7. Anti-inflammatory-dependent anti-aging strategies -- Chapter 8. Spermidine, an autophagy inducer, as a therapeutic anti-aging strategy -- Chapter 9. Melatonin in Aging and Aging Related Disorders -- Chapter 10. Intermittent fasting as an anti- aging strategy -- Chapter 11. The role of curcumin as an anti-aging compound -- Chapter 12. The Role of Telomerase Activators in Anti-Aging Strategies and Their Clinical Potential -- Chapter 13. Clinical Laboratories and Their Role in Anti-Aging Strategies -- Chapter 14. Antiaging strategies based on sirtuin activation -- Chapter 15. A vaccine for the pandemic of ageing? Conceptual and ethical issues -- Chapter 16. Cognitive and emotional ageing across the life span: Implications for building the cognitive reserve and resilience -- Chapter 17. Tissue reconstructive & regenerative medicine approach as an anti-ageing intervention: Relevance to age-induced Osteoarthritis -- Chapter 18. Age-Adjustment Expertise in Animal Models of Human Diseases.
    Abstract: The book focuses on the emerging anti-aging approaches for maintaining better health in old age. It provides a current understanding of the underlying principle, possible targets, implementation approaches, and efficacy of the various anti-aging strategies. The chapters include a wide range of topics incorporating the major advances in anti-aging strategies, including telomerase activation, stem cell therapy, autophagy induction, sirtuin activation, and dietary restrictions. Further, it discusses the epigenetic mechanisms underlying aging-related processes and epigenetic strategies to delay and reverse aging-related diseases. The book covers the strategy based on tissue engineering and regenerative medicine for understanding the complexity of aging and restoring the functionalities of organ systems. It further presents the applications of melatonin supplementation-based anti-aging therapeutic intervention. Finally, the book reviews the ethical dimension of anti-aging intervention strategies. This book is immensely useful to scientists and researchers from various disciplines in the life sciences. .
    Type of Medium: Online Resource
    Pages: XIV, 340 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811974434
    DDC: 612.028
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Regenerative medicine. ; Veterinary medicine. ; Animal biotechnology. ; Biomedical engineering. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Veterinary Science. ; Animal Biotechnology. ; Biomedical Engineering and Bioengineering. ; Biotechnology.
    Abstract: Do cephalopods change color when under distress? Is the reptilian heart analogous to a diaphragm positive displacement pump? Are digital twins the answer for animal experimentation? This book explores the new field of veterinary engineering science and discusses how to better measure vital signs in exotic and companion animals. A vast opportunity exists for developing novel technologies that target reductions to the number of invasive procedures patients are subjected to. We examine improvements to animal care and enhancement of animal welfare while creating a more sustainable veterinary healthcare ecosystem. The authors address the challenges engineers face in designing healthcare equipment for animals and how the field of veterinary engineering contributes to traditional veterinary medicine. This book brings a novel field of engineering to train future veterinarians and engineers on design and application of technology to veterinary medicine.
    Type of Medium: Online Resource
    Pages: XI, 156 p. 25 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031228056
    DDC: 612.028
    Language: English
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  • 60
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biology Technique. ; Experimental immunology. ; Pharmaceutical chemistry. ; Medicine Research. ; Biology Research. ; Cytology. ; Clinical biochemistry. ; Immunological Techniques. ; Pharmaceutics. ; Biomedical Research. ; Cell Biology. ; Medical Biochemistry.
    Description / Table of Contents: Antibody-Drug Conjugates Basic Concepts and Structures -- Relationship between target and specific action of antibody-drugs conjugates -- The internalization and therapeutic activity of antibody drug conjugate -- The internalization and intracellular trafficking of ADC -- Distribution and metabolism of antibody-drug conjugates -- Application of Antibody fragments in ADCs -- Novel Targeting Carriers in Antibody-drug Conjugates -- Site-specified Conjugating Technology and Application -- Determination of drug-to-antibody ratio of ADCs -- Pharmacokinetic study of antibody-drug conjugates.
    Abstract: This book summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and structure of ADCs, and the relationship between the targets of ADCs and their specific functions. The second part mainly introduces the endocytosis and intracellular metabolism of ADCs, including the relationship between endocytosis and ADC activity, the endocytosis and intracellular transport of ADCs, the distribution and metabolism of ADC in vivo. Then it discusses the new formats and research technology of ADCs, including the application of miniaturized antibodies in ADC synthesis, novel carriers for ADC design, the technology and application of site-specific conjugation, and approaches for analyzing the drug: antibody ratio (DAR), the study of pharmacokinetics of ADCs. This book combines the basic theory with the research technology. It can be used as a reference book for students, teachers and researchers of biomedical field.
    Type of Medium: Online Resource
    Pages: IX, 135 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811956386
    DDC: 571.96028
    Language: English
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  • 61
    Keywords: Forestry. ; Agriculture. ; Agronomy. ; Subsistence farming. ; Forestry. ; Agriculture. ; Agronomy. ; Subsistence Agriculture.
    Description / Table of Contents: Part I: Progress Towards Sustainable Intensification and Climate Change -- Chapter 1. Introduction: Agroforestry for Sustaining the Global Agriculture in Changed Environment -- Chapter 2. Agroforestry Matches the Evolving Climate Change Mitigation and Adaptation Agenda in Asia and Africa -- Chapter 3. Farmer Managed Natural Regeneration in Africa: Evidence for Climate Change Mitigation and Adaptation in Drylands -- Chapter 4. Urban and Peri-urban Agroforestry to Sustain Livelihood and Food Security in the Face of Global Environmental Change and Epidemic Threats -- Part II. Landscape Restoration and Combating Desertification -- Chapter 5. Agroforestry for Climate Change Resilience in Degraded Landscapes -- Chapter 6. The Great Green Wall Initiatives and Opportunities for Integration of Dryland Agroforestry to Mitigate Desertification -- Chapter 7. Silvopastoral Systems on Degraded Lands for Soil Carbon Sequestration and Climate Change Mitigation -- hapter 8. Utilization of Saline and Other Poor-quality Waters to Sustain Agroforestry Production -- Chapter 9. Potential of Agroforestry Systems for Food Security, Climate Change Mitigation, Landscape Restoration and Disaster Risk Reduction in Nepal -- Part III: Biodiversity and Ecosystem Services -- Chapter 10. The Role of Agroforestry Systems for Enhancing Biodiversity and Provision of Ecosystem Services in Agricultural Landscapes in Southeast Asia -- Chapter 11. Potentials of Indigenous Fruit Trees in Enhancing Nutrition, Income and Biodiversity Conservation in African Agroforestry -- Chapter 12. Ethnic Homestead Gardens: Diversity, Management and Conservation -- Chapter 13. Agroforestry for Plant Diversity and Livelihood Security in Southwest Asia -- Chapter 14. Achieving Biodiversity Conservation, Livelihood Security and Sustainable Development Goals through Agroforestry in Coastal and Island Regions of India and South East Asia -- Chapter 15. Biodiversity and Ecosystems Services of the Agroforestry Systems of the Himalayan Region: An Overview -- Chapter 16. Soil Biodiversity and Litter Decomposition in Agroforestry Systems of the Tropical Regions of Asia and Africa -- Part IV: Analytical Approaches and Policy Perspective -- Chapter 17. Agroforestry Suitability Mapping: A Geospatial Approach for Quantifying Land Potential for Intensification -- Chapter 18. Agroforestry as a Climate-Smart Agriculture: Strategic Interventions, Current Practices and Policies -- Chapter 19. Agroforestry as a Key Intervention to Achieve Nationally Determined Contribution (NDC) Targets -- Chapter 20. Potential of Traditional Agroforestry Systems for Intensification of Agriculture and Meeting Global Goals: Lessons from Asia and Africa -- Chapter 21. A Framework for Analysing Spatial Patterns and Extent of Influence by Single Trees on Ecosystem Properties in Agroforestry -- Chapter 22. Integrating Moringa oleifera and Moringa stenopetala in Agroforestry for Adaptation and Mitigation of Climate Change in Asia and Africa -- Chapter 23. Payment for Ecosystem Services from Agroforestry: Case Studies and Lessons -- Chapter 24. Agroforestry for Sustaining Industrial Raw Materials: Experience from a Value Chain Leveraged Consortium Model -- Chapter 25. Synthesis: Agroforestry for Sustainable Intensification of Agriculture in Asia and Africa.
    Abstract: This edited book opens up new vistas for sustainable intensification in agriculture to provide food to ever growing population as well as adapting to the risks of global environmental change. Diverting from conventional agriculture, the book explores new dimensions and concepts that have been identified for future research and development in sustaining agriculture in Asia and Africa regions. The chapters are written by leading researchers and practitioners in the field of agroforestry. The book demonstrates how agroforestry could be instrumental in bringing stability and sustainability in agricultural production. It offers sustainable solutions for the impending problems of climate change, ecosystem degradation, declining agricultural productivity, and uncertain food security. It is an essential resource for students in agroforestry courses, as well as a valuable introduction to the field for professionals in related areas.
    Type of Medium: Online Resource
    Pages: XXII, 816 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811946028
    Series Statement: Sustainable Agriculture and Food Security,
    DDC: 634.9
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Agriculture. ; Control engineering. ; Robotics. ; Automation. ; Geographic information systems. ; Food science. ; Agriculture. ; Control, Robotics, Automation. ; Geographical Information System. ; Food Science.
    Description / Table of Contents: Fundamentals of Tree and Vine Physiology -- Mechanical Management of Modern Planar Fruit Tree Canopies -- Orchard Water Management -- Vineyard Water Management -- Pests and diseases management -- Advanced Technologies for Crop-load Management -- Mechanical Harvesting -- Autonomous Platforms -- Management Information Systems and Emerging Technologies -- Economic and Societal Aspects.
    Abstract: Modern tree fruit orchards and vineyards constitute complex production systems that are exposed to highly dynamic and stochastic natural, financial and societal forces, and face demands for increased production using fewer resources, with reduced environmental impact. Successful operation of orchards and vineyards under these conditions is practically impossible without careful and extensive use of state-of-the-art automation technologies and careful planning of future operations (e.g., training systems when replanting) that can be enabled by knowledge of emerging technologies and future trends. Also, improvement of existing automation technologies and development of novel future systems cannot be accomplished without a working understanding of the tree and vine biological production systems, their management needs, and the capabilities and limitations of existing automation systems. The book aims to provide the necessary knowledge to achieve the above goals in a way that can engage readers without engineering or horticultural backgrounds. .
    Type of Medium: Online Resource
    Pages: VII, 241 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031269417
    Series Statement: Agriculture Automation and Control,
    DDC: 630
    Language: English
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  • 63
    Keywords: Pharmacology. ; Immunology. ; Pharmacology. ; Immunology.
    Description / Table of Contents: Preface Chapter 1: Overview of the Immune System and its Pharmacological Targets -- Chapter 2: Modulation of the Innate Immune System -- Chapter 3: Modulation of the Adaptive Immune System -- Chapter 4: Respiratory Disorders of the Immune System and their Pharmacological Treatment -- Chapter 5: Inflammation of the Skin and its therapeutic topics -- Chapter 6: Inflammatory Diseases of the Gastrointestinal Tract and Pharmacological Treatments -- Chapter 7: Mechanisms of Autoimmunity and Pharmacologic Treatments -- Chapter 8: Transplantation: Immunologic Principles and Pharmacologic Agents -- Chapter 9: Immunopathogenesis, Immunization, and Treatment of Infectious Diseases -- Chapter 10: Cancer Immunotherapy.
    Abstract: Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are discussed in detail. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.” Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.
    Type of Medium: Online Resource
    Pages: XIX, 399 p. 118 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030199227
    DDC: 615
    Language: English
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    Keywords: Biodiversity. ; Water. ; Hydrology. ; Freshwater ecology. ; Marine ecology. ; Biotic communities. ; Animal culture. ; Science Study and teaching. ; Biodiversity. ; Water. ; Freshwater and Marine Ecology. ; Ecosystems. ; Animal Science. ; Science Education.
    Description / Table of Contents: 1. Science for the Future: The Use of Citizen Science in Marine Research and Conservation -- 2. A Literature Review on Stakeholder Participation in Coastal and Marine Fisheries -- 3. Law and Policy Dimensions of Ocean Governance -- 4. Status and Threats to Marine Biodiversity in the Anthropocene -- 5. Challenges in Marine Restoration Ecology: How Techniques, Assessment Metrics and Ecosystem Valuation can lead to Improved Restoration Success -- 6. Understanding how Microplastics Affect Marine Biota on the Cellular Level is Important for Assessing Ecosystem Function – A Review -- 7. Chemical Biodiversity and Bioactivities of Saponins in Echinodermata with an Emphasis on Sea Cucumbers (Holothuroidea) -- 8. Secondary Metabolites of Marine Microbes: From Natural Products Chemistry to Chemical Ecology -- 9. Sponges Revealed: A Synthesis of their Overlooked Ecological Functions within Aquatic Ecosystems -- 10. Theories, Vectors, and Computer Models – Marine Invasion Science in the Anthropocene -- 11. Benthos-Pelagos Interconnectivity: Antarctic Shelf Examples -- 12. Investigating the Land-Sea Transition Zone -- 13. Fisheries and Tourism: Social, Economic and Ecological Trade-offs in Coral Reef Systems -- 14. Progress in Microbial Ecology in Ice Covered Seas -- 15. Complex Interactions Between Aquatic Organisms and Their Chemical Environment Elucidated from Different Perspectives.
    Abstract: This open access book summarizes peer-reviewed articles and the abstracts of oral and poster presentations given during the YOUMARES 9 conference which took place in Oldenburg, Germany, in September 2018. The aims of this book are to summarize state-of-the-art knowledge in marine sciences and to inspire scientists of all career stages in the development of further research. These conferences are organized by and for young marine researchers. Qualified early-career researchers, who moderated topical sessions during the conference, contributed literature reviews on specific topics within their research field. .
    Type of Medium: Online Resource
    Pages: XIX, 370 p. 78 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030203894
    DDC: 333.95
    Language: English
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    Keywords: Agriculture. ; Nutrition   . ; Plant biotechnology. ; Food science. ; Agriculture Economic aspects. ; Agriculture. ; Nutrition. ; Plant Biotechnology. ; Food Science. ; Agricultural Economics.
    Description / Table of Contents: Preface -- Global Food Security, Contributions from Sustainable Potato Agri-Food Systems -- The Potato and its Contribution to the Human Diet -- Enhancing Value Chains through Collective Actions: Lessons From the Andes, Africa and Asia -- Ex situ Conservation of Potato [Solanum Section Petota (Solanaceae)] Genetic Resources in Genebanks -- The Genes and Genomes of the Potato -- Potato Breeding -- Genetics and Cytogenetics of Potato -- Insect Pests Affecting Potatoes in Tropical, Subtropical and Temperate Regions -- Fungal, Oomycete and Plasmodiophorid Diseases of Potato -- Bacterial Diseases of Potato -- Viral Diseases in Potato -- Potato Seed Systems -- Participatory Research (PR) at CIP with Potato Farming Systems in the Andes: Evolution and Prospects -- Gender Topics on Potato Research and Development -- Index. .
    Abstract: This book is open access under a CC BY 4.0 license. This book provides a fresh, updated and science-based perspective on the current status and prospects of the diverse array of topics related to the potato, and was written by distinguished scientists with hands-on global experience in research aspects related to potato. The potato is the third most important global food crop in terms of consumption. Being the only vegetatively propagated species among the world’s main five staple crops creates both issues and opportunities for the potato: on the one hand, this constrains the speed of its geographic expansion and its options for international commercialization and distribution when compared with commodity crops such as maize, wheat or rice. On the other, it provides an effective insulation against speculation and unforeseen spikes in commodity prices, since the potato does not represent a good traded on global markets. These two factors highlight the underappreciated and underrated role of the potato as a dependable nutrition security crop, one that can mitigate turmoil in world food supply and demand and political instability in some developing countries. Increasingly, the global role of the potato has expanded from a profitable crop in developing countries to a crop providing income and nutrition security in developing ones. This book will appeal to academics and students of crop sciences, but also policy makers and other stakeholders involved in the potato and its contribution to humankind’s food security. .
    Type of Medium: Online Resource
    Pages: XVII, 518 p. 99 illus., 91 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030286835
    DDC: 630
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Microbiology. ; Biotechnology. ; Evolution (Biology). ; Biomaterials. ; Nucleic acids. ; Cytology. ; Microbiology. ; Biotechnology. ; Evolutionary Biology. ; Nucleic Acid. ; Cell Biology.
    Description / Table of Contents: Reduced and Minimal Cell Factories in Bioprocesses: Towards a Streamlined Chassis -- Construction of minimal genomes and synthetic cells -- Engineering reduced-genome strains of Pseudomonas putida for product valorization -- Genome-reduced Corynebacterium glutamicum fit for biotechnological applications -- Reduction of the Saccharomyces cerevisiae genome: challenges and perspectives -- The use of in silico genome-scale models for the rational design of minimal cells -- From minimal to minimized genomes: Functional design of microbial cell factories -- Resource allocation principles and minimal cell design.
    Abstract: This book provides a comprehensive overview of the design, generation and characterization of minimal cell systems. Written by leading experts, it presents an in-depth analysis of the current issues and challenges in the field, including recent advances in the generation and characterization of reduced-genome strains generated from model organisms with relevance in biotechnology, and basic research such as Escherichia coli, Corynebacterium glutamicum and yeast. It also discusses methodologies, such as bottom-up and top-down genome minimization strategies, as well as novel analytical and experimental approaches to characterize and generate minimal cells. Lastly, it presents the latest research related to minimal cells of serveral microorganisms, e.g. Bacillus subtilis. The design of biological systems for biotechnological purposes employs strategies aimed at optimizing specific tasks. This approach is based on enhancing certain biological functions while reducing other capacities that are not required or that could be detrimental to the desired objective. A highly optimized cell factory would be expected to have only the capacity for reproduction and for performing the expected task. Such a hypothetical organism would be considered a minimal cell. At present, numerous research groups in academia and industry are exploring the theoretical and practical implications of constructing and using minimal cells and are providing valuable fundamental insights into the characteristics of minimal genomes, leading to an understanding of the essential gene set. In addition, research in this field is providing valuable information on the physiology of minimal cells and their utilization as a biological chassis to which useful biotechnological functions can be added.
    Type of Medium: Online Resource
    Pages: VII, 230 p. 35 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030318970
    DDC: 579
    Language: English
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    Keywords: Genetics. ; Radiation dosimetry. ; Cancer. ; Radiology. ; Human physiology. ; Biophysics. ; Genetics and Genomics. ; Radiation Dosimetry and Protection . ; Cancer Biology. ; Radiology. ; Human Physiology. ; Biophysics.
    Description / Table of Contents: Part 1. The Environmental Pollution Caused by the Fukushima Daiichi Nuclear Power Plant (FNPP) Accident -- 1. Estimation of Dose Rate for the Large Japanese Field Mice (Apodemus speciosus) Distributed in the “Difficult-to-Return Zones” in Fukushima Prefecture -- 2. Impacts of the Fukushima Nuclear Accident on Fishery Products and Fishing Industry -- 3. Incorporation and Accumulation of Strontium-90 in the Hard Tissue of Animals and Their Relationship with Strontium-90 Pollution in the Environment -- Part 2. Radiation Exposure and Its Effects on Wild Organisms after the FNPP Accident -- 4. Radioactive Cesium Contamination of Arthropods and Earthworms after the FNPP accident -- 5. Delayed Recovery from Declines in the Population Densities and Species Richness of Intertidal Invertebrates near the Fukushima Daiichi Nuclear Power Plant -- 6. Mutations observed in mitochondrial DNA of salmon collected in Mano River, Fukushima Prefecture, Japan -- 7. Influence of the FNPP Accident on Coniferous Trees: A Review -- Part 3. Radiation Exposure and Its Effects on Livestock after the FNPP Accident -- 8. Analysis of Ovaries and Fertilities in Domestic Animals affected by the Fukushima Daiichi Nuclear Power Plant Accident -- 9. Transgenerational Effects on Calf Spermatogenesis and Metabolome Associated with Paternal Exposure to the FNPP Accident -- 10. The Effect of Radiation on the Immune System in Pigs Affected by the Fukushima Daiichi Nuclear Power Plant Accident -- 11. Assessment of DNA Damage Induction in Farm Animals after the Fukushima Daiichi Nuclear Power Plant Accident -- Part 4. Dose Evaluation in Association with the FNPP Accident -- 12. Preliminary Study on Electron Spin Resonance Dosimetry Using Affected Cattle’s Teeth due to the Fukushima Daiichi Nuclear Power Plant Accident -- 13. Estimation of External and Internal Exposure in Japanese Macaques after the Fukushima Daiichi Nuclear Power Plant Accident -- Part 5. New Perspectives Raised after the FNPP Accident -- 14. Properties of Radioactive Cs-bearing Particles Released by the Fukushima Daiichi Nuclear Power Plant Accident and Trace Element Analysis -- 15. Cellular Effects of Insoluble Particles Containing Radioactive Cesium -- 16. Preparation and Genome Analysis of Immortalized Cells Derived from Wild Macaques Affected by the Fukushima Daiichi Nuclear Power Plant Accident -- 17. Effects of Radioactive Cesium-containing Water on Mice -- Prt 6. Overview of the FNPP accident -- 18. Comparison of Radioactivity Release and Contamination from the Fukushima and Chernobyl Nuclear Power Plant Accidents -- 19. The Pale Grass Blue Butterfly as an Indicator for the Biological Effect of the Fukushima Daiichi Nuclear Power Plant Accident -- 20. What We Learned and are Learning from the Affected Animal Dose Assessment Project. .
    Abstract: This open access book summarizes the latest scientific findings regarding the biological effects of the Fukushima Daiichi Nuclear Power Plant (FNPP) accident in 2011. Various cases of changes in animals and organisms have been reported since the FNPP accident. However, it is often unknown whether they are actually due to radiation, since the dose or dose-rate are not necessarily associated with the changes observed. This book brings together the works of radiation biologists and ecologists to provide reliable radioecology data and gives insight into future radioprotection. The book examines the environmental pollution and radiation exposure, and contains valuable data from abandoned livestock in the ex-evacuation zone and from wild animals including invertebrates and vertebrates, aqueous and terrestrial animals, and plants that are subjected to long-term exposure in the area still affected by radiation. It also analyzes dose evaluation, and offers new perspectives gained from the accident, as well as an overview for future studies to promote radioprotection of humans and the ecosystem. Since the biological impact of radiation is influenced by various factors, it is difficult to scientifically define the effects of low-dose/low-dose-rate radiation. However, the detailed research data presented can be combined with the latest scientific and technological advances, such as artificial intelligence, to provide new insights in the future. This book is a unique and valuable resource for researchers, professionals and anyone interested in the impact of exposure to radiation or contamination with radioactive materials.
    Type of Medium: Online Resource
    Pages: XV, 264 p. 90 illus., 65 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811382185
    DDC: 576.5
    Language: English
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    Keywords: Evolution (Biology). ; Environment. ; History. ; Conservation biology. ; Ecology . ; Ethics. ; Environmental sciences Social aspects. ; Evolutionary Biology. ; Environmental Sciences. ; History. ; Conservation Biology. ; Moral Philosophy and Applied Ethics. ; Environmental Social Sciences.
    Description / Table of Contents: Part I. Biology and Culture -- Chapter 1. Speciesism in Biology and Culture: How Human Exceptionalism is Pushing Planetary Boundaries -- Chapter 2. Race and Human Genomic Variation -- Chapter 3. Science Without Species: Doing Science With Tree-Thinking -- Part II. Culture and History -- Chapter 4. The Colonization of Islands as Microcosms for Human Impacts on an Interplanetary Scale -- Chapter 5. Species, God, and Dominion -- Chapter 6. Symbols and How We Came to be Human -- Part III. Conservation and Law -- Chapter 7. Law and Nature: Human, Nonhuman, and Ecosystem Rights -- Chapter 8. A Phylogenetic Approach to Conservation: Biodiversity and Ecosystem Functioning for a Changing Globe -- Part IV. Sustainability and the Future -- Chapter 9. Energy and Society: Toward a Sustainable Future.
    Abstract: This open access book explores a wide-ranging discussion about the sociopolitical, cultural, and scientific ramifications of speciesism and world views that derive from it. In this light, it integrates subjects across the natural sciences, social sciences, and humanities. The 21st-century western world is anthropocentric to an extreme; we adopt unreasonably self-centered and self-serving ideas and lifestyles. Americans consume more energy resources per person than most other nations on Earth and have little concept of how human ecology and population biology interface with global sustainability. We draw upon religion, popular culture, politics, and technology to justify our views and actions, yet remain self-centered because our considerations rarely extend beyond our immediate interests. Stepping upward on the hierarchy from “racism,” “speciesism” likewise refers to the view that unique natural kinds (species) exist and are an important structural element of biodiversity. This ideology manifests in the cultural idea that humans are distinct from and intrinsically superior to other forms of life. It further carries a plurality of implications for how we perceive ourselves in relation to nature, how we view Judeo-Christian religions and their tenets, how we respond to scientific data about social problems such as climate change, and how willing we are to change our actions in the face of evidence. .
    Type of Medium: Online Resource
    Pages: XVI, 203 p. 28 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030990312
    DDC: 576.8
    Language: English
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    Keywords: Zoology. ; Human evolution. ; Anthropology. ; Physical anthropology. ; Animal culture. ; Zoology. ; Evolutionary Anthropology. ; Physical-Biological Anthropology. ; Animal Science.
    Description / Table of Contents: Introduction -- Part 1-Human Influences on Primate Habitats -- Forest Fragmentation -- Primates in Regenerating Forest -- Responses of primates to roads: Dispersal barriers, mortality, and secondary effects -- Hunting by humans -- Primate-dog interactions -- Primate Tourism -- Infectious disease -- Climate change impacts on non-human primates – what have we modelled and what do we do now? -- PART 2: PRIMATES IN HUMAN-DOMINATED LANSCAPES -- Community-based conservation strategies to promote primate conservation in agricultural landscapes -- Translocated primate populations -- Translocated primate populations -- Exploring the human-primate interface -- Planning primate conservation in shared landscapes -- Non-pathogenic influences on primate health and behaviour -- PART 3: PRIMATES IN CAPTIVITY -- Anthropogenic and observer effects on primate behaviour: Perspectives on the continuum of wild-captive behaviour -- The primate pet trade -- Rescue, rehabilitation, and reintroduction.
    Abstract: The field of primatology has expanded substantially in the last twenty years, particularly with regard to studies of primates in human-altered landscapes. This text aims to review the recent literature on anthropogenic (of human origin) influences on non-human primates, bringing an overview of this important area of primatology together for students. Chapters are grouped into three sections, representing the many ways anthropogenic activities affect primate populations. The first section, ‘Human Influences on Primate Habitat’, covers ways in which wild primates are affected by human actions, including forest fragmentation, climate change, and the presence of dogs. Section two, ‘Primates in Human-Dominated Landscapes’, looks at situations where non-human primates and humans share space; this includes primates in urban environments, primate tourism, and primates in agroecosystems. The final section, ‘Primates in Captivity’, looks at primate behaviour and welfare in captive situations, including zoos, the primate pet trade, and in entertainment.
    Type of Medium: Online Resource
    Pages: XIII, 346 p. 36 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031117367
    Series Statement: Developments in Primatology: Progress and Prospects,
    DDC: 590
    Language: English
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    Keywords: Immunology. ; Medicine History. ; Medicine Research. ; Biology Research. ; Immunology. ; History of Medicine. ; Biomedical Research.
    Description / Table of Contents: A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Z.
    Abstract: Hundreds of eponyms are used within the field of immunology—Petri dish, Crohn’s disease, Bence Jones protein, Kupffer cells, Freund's adjuvant, Ouchterlony immunodiffusion, to name just a few—but most of us don't know much about the individuals who gave their names to these terms. Where were they born and educated, what other accomplishments are they credited with, why has history chosen to remember them, or not? This book presents the first comprehensive collection of immunologic eponyms, and through them tells the story of this fascinating field, from its earliest beginnings to present day. Organized by surname and meticulously cross-referenced and indexed, this book offers historical anecdotes and little-known facts which scientists, clinicians, students, and general readers will find captivating and memorable. A one-of-a-kind introduction to immunology that serves as both a history lesson and current reference on the diseases, treatments, and individuals who have been crucial to this field.
    Type of Medium: Online Resource
    Pages: XXVIII, 405 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031145292
    DDC: 571.96
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biology Technique. ; Food Microbiology. ; Food science. ; Biological Techniques. ; Food Microbiology. ; Food Science.
    Description / Table of Contents: Chapter 1. History and Technology of Chinese Liquor -- Chapter 2. Classification of Chinese Baijiu -- Chapter 3.Baijiu-Making Equipments -- Chapter 4. Process Principles and Engineering of Solid-State Fermentation of Chinese Liquor -- Chapter 5. Solid-state Distillation of Chinese Liquor (Baijiu) -- Chapter 6. History and advance of flavour research of Baijiu -- Chapter 7. Sensory Properties of Baijiu -- Chapter 8. Chemical Components of Chinese Baijiu -- Chapter 9. Microbial Diversities During Chinese Liquor Fermentations -- Chapter 10. Composition and Succession of the Microbiota in Light-Aroma Baijiu Production -- Chapter 11. Diversity and Succession of the Microbiota in Sauce-Aroma Baijiu -- Chapter 12. Composition, Succession and Key Species of Microbiota in Strong-Aroma Baijiu Production -- Chapter 13. Functional Microorganisms Associated with Baijiu Fermentation -- Chapter 14. Microbial interaction in Chinese liquor fermentation -- Chapter 15. Regulation of the microbiota in Chinese liquor fermentation process -- Chapter 16. Challenges and Perspectives (Strategies).
    Abstract: This book provides a cutting-edge scientific overview of Chinese liquor, also known as Baijiu. Chinese liquor is one of the world’s most ancient fermented alcoholic beverages. Fermented foods and beverages are consumed worldwide as an indispensable constituent in our daily life. However, most fermented foods rely on traditional techniques with limited known scientific knowledge. These indigenous processes are typically empirical without scientifically-based control and technological insights. The book analyses Chinese liquor processing on the three most important disciplines of fermented foods: process technology/engineering, flavor chemistry, and microbiology. It also addresses the perspectives and future research needs associated with spontaneous fermented foods. This book offers a deep understanding of the science of Chinese liquor production to students, researchers, and related practitioners both in the academic and the industry. It would also benefit many other fields of fermented foods for their optimization, standardization, and modernization.
    Type of Medium: Online Resource
    Pages: XIX, 608 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811921957
    DDC: 570.28
    Language: English
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    Keywords: Microbial ecology. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Water. ; Hydrology. ; Sustainability. ; Biotic communities. ; Microbial Ecology. ; Environmental Engineering/Biotechnology. ; Water. ; Sustainability. ; Ecosystems.
    Description / Table of Contents: Preface -- Foreword -- 1. Concerns and Threats of Contamination on Aquatic Ecosystems -- 2. Effect of Pesticides on Fish Fauna: Threats, Challenges and Possible Remedies -- 3. Impact of Invasive Plants in Aquatic Ecosystems -- 4. Role of Modern Innovative Techniques for Assessing and Monitoring Environmental Pollution -- 5. Global Scenario of Remediation Techniques to Combat Environmental Pollution -- 6. Biopesticides: clean and viable technology for healthy environment -- 7. Inoculum addition in the presence of plant rhizosphere for petroleum polluted soil remediation -- 8. Vermicomposting: An Eco-friendly Approach for Recycling /Management of Organic Wastes -- 9. Bio-Fertilizers: Ecofriendly Approach for Plant and Soil Environment -- 10. Phytoremediation of heavy metals: an ecofriendly and sustainable approach -- 11. Credibility of in situ Phytoremediation for Restoration of Disturbed Environments -- 12. Role of White Willow (Salix alba L.) for Cleaning up the Toxic Metal Pollution -- 13. Mycoremediation: a Sustainable Tool for Abating Environmental Pollution -- 14. Microbial Biofilm Cell Systems for Remediation of Wastewaters -- 15. Pollution remediation by way of using genetically modified plants (GMP) -- Index.
    Abstract: Toxic substances threatens aquatic and terrestrial ecosystems and ultimately human health. The book is a thoughtful effort in bringing forth the role of biotechnology for bioremediation and restoration of the ecosystems degraded by toxic and heavy metal pollution. The introductory chapters of the book deal with the understanding of the issues concerned with the pollution caused by toxic elements and heavy metals and their impacts on the different ecosystems followed by the techniques involved in monitoring of the pollution. These techniques include use of bio-indicators as well as modern techniques for the assessment and monitoring of toxicants in the environment. Detailed chapters discussing the role of microbial biota, aquatic plants, terrestrial plants to enhance the accumulation efficiency of these toxic and heavy metals are followed by remediation techniques involving myco-remediation, bio-pesticides, bio-fertilizers, phyto-remediation and rhizo-filtration. A sizable portion of the book has been dedicated to the advanced bio-remediation techniques which are finding their way from the laboratory to the field for revival of the degraded ecosystems. These involve bio-films, micro-algae, genetically modified plants and filter feeders. Furthermore, the book is a detailed comprehensive account for the treatment technologies from unsustainable to sustainable. We believe academicians, researchers and students will find this book informative as a complete reference for biotechnological intervention for sustainable treatment of pollution.
    Type of Medium: Online Resource
    Pages: XVIII, 327 p. 47 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030356910
    DDC: 579.17
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant genetics. ; Plant biotechnology. ; Agriculture. ; Plant Genetics. ; Plant Biotechnology. ; Agriculture.
    Description / Table of Contents: Introduction -- Botanical descriptions -- Medicinal properties: bioactives and their actions -- Genetic resources and genetic diversity -- Cytogenetical analysis of bitter gourd genome -- Sex determination -- Tissue culture, genetic engineering & nanotechnology -- Classical genetics and traditional breeding -- Molecular linkage mapping: Map construction and mapping of genes/QTLs -- Genome sequence and its comparative study with other Cucurbitaceae genome -- Functional genomics: metabolomics, transcriptomics (including biochemical study of interaction with parasite) -- Future Prospects.
    Abstract: This book focusing on the bitter gourd genome is the first comprehensive compilation of knowledge on the botany, cytogenetical analysis, genetic resources and diversity, traditional breeding, tissue culture and genetic transformation, whole genome sequencing and comparative genomics in the Cucurbitaceae family. It discusses the biochemical profile of the bioactives present in this horticultural crop, used both as a vegetable and as a medicine, and also addresses sex determination in bitter gourd. Written by respected international experts, the book is useful to students, teachers and scientists in academia, as well as seed companies and pharmaceutical industries.
    Type of Medium: Online Resource
    Pages: XXI, 135 p. 25 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030150624
    Series Statement: Compendium of Plant Genomes,
    DDC: 581.35
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Nanotechnology. ; Microtechnology. ; Microelectromechanical systems. ; Genetics. ; Biotechnology. ; Nanotechnology. ; Microsystems and MEMS. ; Genetics and Genomics. ; Chemical Bioengineering.
    Description / Table of Contents: Introduction: DNA basics (a primer on DNA) -- Hiding and storing messages and data in DNA -- DNA as a nanoscale building material -- DNA machines and nanobots -- DNA-based nanoelectronics -- Concluding remarks.
    Abstract: This is the first book portraying to a wide readership many fields of DNA in the world of materials altogether in a single volume. The book provides underlying concepts and state-of-art developments in the emerging fields of DNA electronics, structural DNA nanotechnology, DNA computing and DNA data storage, DNA machines and nanorobots. Future possibilities of innovative DNA-based technologies, such as DNA cryptography, DNA identity tags, DNA nanostructures in biosensing and nanomedicine, as well as DNA-based nanoelectronics are all covered, too. This book is valuable for university students studying engineering and technology; biotech, nanotech, and medical device R&D managers, practitioners and investors; and IP analysts who would like to extend their background in advanced DNA technologies. It is nicely illustrated, which makes it very readable, and it conveys science and principles in a lively language to appeal to a broad audience, from professionals and academics to students and lay readers. Advance Praise for DNA Beyond Genes: “Most students of DNA, and lay readers as well, are interested in the absolutely essential role it plays in biology. However, the properties which make DNA the carrier of genetic information also make it an extraordinary material that can be used as the backbone for a wide variety of nanoengineering applications – these range from information storage and computation to molecular machines and devices to artfully designed logos and symbols. The perfect self-recognition of DNA sequences makes it an ideal building block to synthesize more and more elaborate constructions and imaginative scientists have probably only just scratched the surface of what can eventually be created. Here for the first time in this wonderful book Vadim Demidov explores the full range of the non-biological applications of DNA.” Charles R. Cantor Professor Emeritus of Biomedical Engineering, Boston University Member of the USA National Academy of Sciences.
    Type of Medium: Online Resource
    Pages: XX, 107 p. 66 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030364342
    DDC: 660.6
    Language: English
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    Keywords: Plants Development. ; Landscape ecology. ; Plants Evolution. ; Biodiversity. ; Plant physiology. ; Plant Development. ; Landscape Ecology. ; Plant Evolution. ; Biodiversity. ; Plant Physiology.
    Description / Table of Contents: Part 1.Cryopreservation and Biotechnology -- 1.Cryopreservation Development of some endangered Thai Orchid species -- 2.Status of Orchid Industry in India -- 3.Cryobiotechnological studies in Vanilla, the orchid of multi- industrial uses -- 4.In vitro propagation and germplasm conservation of wild orchids from South America -- 5.Postharvest Technology of cut-flowers of Orchids -- 6.Cryobiotechnology of Korean orchid biodiversity: a case study using Cymbidium kanra -- Part 2.Orchid Biodiversity and Conservation -- 7.Species diversity and distribution of Orchids in district Rudraprayag, Uttarakhand, North East Himalaya, India -- 8.Status of genetic diversity and its characterization in genus Bulbophyllum (Orchidaceae) from North-Eastern India -- 9.Orchid diversity in Darjeeling Himalaya, India: Present status and conservation -- 10.Orchid Diversity in the Eastern Ghats of Northern Andhra Pradesh, India -- 11.History and Scientific Potential of the Orchid Collection of the Stoсk Greenhouse of the Main Botanical Garden RAS (Moscow, Russia) -- 12.Status of Orchid Diversity, Conservation, Research and Development in Arunachal Pradesh – An Overview -- Part 3. Anatomy and Physiology -- 13.Orchid mycorrhizal fungi- structure, function, and diversity -- 14.Orchid Seed Ultra structure: Ecological and Taxonomic Implications with reference to Epidendroideae (Orchidaceae) -- 15.Structural Adaptations of Bulbophyllum and Dendrobium (Orchidaceae) to the Epiphytic Habitat and their Phylogenetic Implications -- 16.Physiological response of Dendrobium cv. Earsakul to plant growth promoters and growing systems -- 17.Anatomical studies in some Indian Coelogyneae (Orchidaceae)., Part 4. Pollination Biology -- 18.Beauty of Orchid Flowers: Are not adequate to lure Indian biologists? -- 19.Evolution of Organismal Female Wasp Mimics in Sexually Deceptive Orchid genus Chiloglottis (Orchidaceae) -- 20.Pollination studies in the genus Habenaria Willd. (Orchidaceae) from Western Ghats -- Part 5. Orchid Chemicals and Bioactive Compounds -- 21.Phytochemical analysis, antioxidant and anti-inflammatory activity of Eria tomentosa (Koen.) Hook. f -- 22.Medicinal orchids: production of bioactive compounds and biomass -- 23.Ethnomedicinal aspects of some Orchids from Darjeeling Himalaya, India -- 24.Evaluation of Phytoconstituents and Antibacterial activity of Vanda tessellata using in vitro model -- 25.Screening of Bioactive Phytochemicals in some Indigenous Epiphytic Orchids of Bangladesh -- 26.GC-MS analysis of organic extracts of Cymbidium aloifolium (L.) Sw. (Orchidaceae) leaves from Eastern Ghats of India -- 27.Anticancer property in Acampe praemorsa and Aerides odorata (Orchidaceae), an in vitro approach -- 28.Phytochemical Screening and Evaluation of Antimicrobial Potential of Dendrobium fimbriatum Hook.
    Abstract: This book on “Orchid Biology: Recent Trends & Challenges” reviews the latest strategies for the preservation and conservation of orchid diversity and orchid germplasm. It is an outcome of the Proceedings of the International Symposium on “Biodiversity of Medicinal Plants & Orchids: Emerging Trends and Challenges” held on 9-11 February 2018 at Acharya Nagarjuna University, India. In addition, eminent orchid experts from around the globe were invited to contribute to this book. All chapters were peer-reviewed by international experts. The Orchidaceae are one of the largest families of flowering plants, comprising over 700 genera and 22,500 species and contributing roughly 40 percent of monocotyledons. They also represent the second-largest flowering plant family in India, with 1,141 species in 166 genera, and contribute roughly 10% of Indian flora. Orchids comprise a unique group of plants and their flowers are among the most enchanting and exquisite creations of nature. Phylogenetically and taxonomically, the Orchidaceae are considered to be a highly evolved family among angiosperms. They show incredible diversity in terms of the shape, size and colour of their flowers, and are of great commercial importance in floriculture markets around the globe. Millions of cut flowers of Cymbidium, Dendrobium, Cattleya, Paphiopedilum, Phalaenopsis, Vanda etc., besides potted orchid plants, are sold in Western Countries and thus, the orchid cut flower industry has now become a multimillion-dollar business in Europe, the USA and South East Asia. Besides their ornamental value, orchids hold tremendous pharmaceutical potential. Root tubers of Habenaria edgeworthii form an important component of the ‘Astavarga’ group of drugs in Ayurvedic medicine. It is an established fact that tubers of some terrestrial orchids have been used to treat diarrhoea, dysentery, intestinal disorders, cough, cold and tuberculosis. Some orchids, particularly those belonging to the genera Aerides, Arachnis, Cattleya, Cymbidium, Dendrobium, Epidendrum, Oncidium, Paphiopedilum, Phalaenopsis, Renanthera, Vanda etc. have been extensively used to produce internationally acclaimed hybrids. Yet paradoxically, Indian orchids are victims of their own beauty and popularity. As a result, their natural populations have been declining rapidly because of unbridled commercial exploitation in India and abroad. In fact, some orchids are now at the verge of extinction, e.g. Renanthera imschootiana, Diplomeris hirsuta, Paphiopedilum fairrieanum, Cypripedium elegans, Taeniophylum andamanicum etc. Given the global importance of orchids in terms of securing human health and wealth, this comprehensive compilation, prepared by international experts, is highly topical. Its content is divided into five main sections: (I) Cryopreservation & Biotechnology, (II) Orchid Biodiversity & Conservation, (III) Anatomy & Physiology, (IV) Pollination Biology and (V) Orchid Chemicals & Bioactive Compounds. All contributions were written by eminent orchid experts/professors from around the world, making the book a valuable reference guide for all researchers, teachers, orchid enthusiasts, orchid growers and students of biotechnology, botany, pharmaceutical sciences and ethnomedicine. It will be equally valuable for readers from the horticultural industry, especially the orchid industry, agricultural scientists and policymakers.
    Type of Medium: Online Resource
    Pages: XVIII, 547 p. 133 illus., 113 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813294561
    DDC: 571.82
    Language: English
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  • 76
    Keywords: Conservation biology. ; Ecology . ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Water. ; Hydrology. ; Sustainability. ; Applied ecology. ; Agriculture. ; Conservation Biology. ; Environmental Engineering/Biotechnology. ; Water. ; Sustainability. ; Applied Ecology. ; Agriculture.
    Description / Table of Contents: Preface -- 1. Causes and Effects of Pesticide and Metal Pollution on Different Ecosystems -- 2. Ecotoxicology of Heavy Metals: Sources, Effects and Toxicity -- 3. Role of Modern Innovative Techniques for Assessing and Monitoring Heavy Metal and Pesticide Pollution in Different Environments -- 4. Global Scenario of Remediation Techniques to Combat Pesticide Pollution -- 5. Mycoremediation: A Sustainable Approach for Pesticide Pollution Abatement -- 6. Bio-pesticides: Application and Possible Mechanism of Action -- 7. Values of Biofertilizers for Sustainable Management in Agricultural Industries -- 8.Role of Macrophytes in Spontaneous Lacustrine Phytofiltration -- 9. Phytoremediation of Heavy Metals Using Salix (Willows) -- 10. Photo catalysis: An Effective Tool for Treatment of Dyes Contaminated Wastewater -- 11. Removal of dyes from waste water by Micellar Enhanced Ultrafiltration -- 12. Biofilm: an innovative modern technology for aquatic pollution remediation -- 13. Heavy Metal Soil Contamination and Bioremediation -- 14. Environmental Biotechnology: For Sustainable Future -- 15. Global Environmental Regulations for Management of Pesticides -- Index.
    Abstract: This book addresses the grave concerns stemming out due to conventional treatment techniques. The main focus of this book revolves round the central kernel of novel technology (bioremediation and biotechnology) which has emerged as an independent warrior to clean up and restore the disturbed environs. Furthermore, this book is a coherent assortment of diverse chapters relevant to the role of biotechnology and bioremediation for restoration of the ecosystems degraded by pesticide and heavy metal pollution. The inaugural chapters deal with the quantification of problem and its magnitude due to pesticides and heavy metals, followed by innovative modern biotechnological and bioremediation treatment technologies and sustainable techniques to remediate the persistent pollutants. It is a detailed comprehensive account for the treatment technologies from unsustainable to sustainable. Academicians, researchers and students shall find it as a complete wrap up regarding biotechnological intervention for sustainable treatment of pollution and shall suffice for the diverse needs of teaching and research.
    Type of Medium: Online Resource
    Pages: XVI, 278 p. 38 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030403331
    DDC: 333.9516
    Language: English
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  • 77
    Keywords: Bacteria. ; Biomaterials. ; Nucleic acids. ; Proteins. ; Medical microbiology. ; Bacteria. ; Nucleic Acid. ; Proteins. ; Medical Microbiology.
    Description / Table of Contents: Part I:Biochemistry/Structural Biology – Enzymes -- Chapter 1: Cyclic Dinucleotide Signaling In Mycobacteria -- Chapter 2: Structure and regulation of EAL domain proteins -- Chapter 3: Insights into the molecular basis of biofilm dispersal from crystal structures of di-domain containing proteins -- Chapter 4: Structure and function of HD-GYP phosphodiesterases -- Chapter 5: A unified catalytic mechanism for c-di-NMP hydrolysis by DHH/DHHA1 phosphodiesterases -- Chapter 6: Enzymatic degradation of linear dinucleotide intermediates of cyclic dinucleotides -- Part II:Biochemistry/Structural Biology – Receptors -- Chapter 7: Detection of cyclic dinucleotide binding proteins -- Chapter 8: Non-canonical c-di-GMP binding modes -- Part III:Biochemistry/Structural Biology – Sensing -- Chapter 9: Sensory domains that control cyclic di-GMP-modulating proteins: a critical frontier in bacterial signal transduction -- Part IV:Cyclic di-AMP biochemistry and physiology -- Chapter 10: Metabolic regulation by cyclic di-AMP signaling -- Chapter 11: Osmoregulation via cyclic-di-AMP signaling -- Part V:Population diversity -- Chapter 12: Measuring individual cell c-di-GMP: Identifying population diversity and c-di-GMP heterogeneity.-Part VI:Cyclic di-GMP and exopolysaccharide regulation -- Chapter 13: Activation of bacterial cellulose biosynthesis by cyclic-di-GMP -- Chapter 14: The Regulation of Alginate Biosynthesis viaC-di-GMPSignaling -- Part VII:Environmental bacteria -- Chapter 15: Cyclic di-GMP Signaling in Bacillus subtilis -- Chapter 16: C-di-GMP signaling systems in the Gram-positive Bacillus cereus group -- Chapter 17: Cyclic-di-AMP in Bacillus subtilisbiofilm formation.-Chapter 18: Regulation by c-di-GMP in Myxococcusxanthus -- Chapter 19: Light-regulated nucleotidesecond messenger signalingin cyanobacteria -- Chapter 20: C-di-GMP-dependent regulation of antibiotic biosynthesis in Lysobacter -- Chapter 21: Cyclic di-GMP signalingin extreme acidophilic bacteria -- Part VIII:Pathogens -- Chapter 22: Signals modulating cyclic di-GMP pathways in Vibrio cholera -- Chapter 23: Cyclic di-GMP regulation of gene expression -- Chapter 24: Cyclic di-GMP signaling in Salmonella enterica serovar Typhimurium -- Chapter 25: Cyclic di-GMP signaling in the phytopathogen Xanthomonas campestris pv. Campestris -- Chapter 26: Cyclic di-AMP in Mycobacterium tuberculosis -- Chapter 27: Cyclic di-AMP signaling in Streptococcus pneumonia -- Part IX:Gram-negative bacteria -- Chapter 28: Regulation of cyclic-di-GMP signaling in Pseudomonas aeruginosa -- Chapter 29: Unconventional Cyclic di-GMPSignalling in Escherichia coli -- Chapter 30: Cyclic di-GMP in Burkholderia spp -- Chapter 31: Cyclic di-GMP and the regulation of biofilm dispersion -- Part X:Cyclic di-GMP signaling in eukaryotes -- Chapter 32: Cyclic-di-GMP activates adenylate cyclase A and protein kinase A to induce stalk formationin Dictyostelium -- Part XI:Interference Strategies -- Chapter 33: Targeting cyclic di-nucleotide signaling with small molecules -- Part XII:Novel cyclic di-nucleotides -- Chapter 34: Cyclic di-GMP signaling gone astray: cGAMP signaling via Hypr GGDEF and HD-GYP enzymes -- Chapter 35: Microbial cyclic GMP-AMP signaling pathways.-Part XIII:Honorary cyclic nucleotides -- Chapter 36: 2’,3’-cyclic mononucleotide metabolism and possible roles in bacterial physiology -- Part XIV:Horizontal gene transfer -- Chapter 37: Horizontal transfer of c-di-GMP associated genes. Theoretical underpinnings and future perspectives.-Part XV:Conclusion -- Chapter 38: Conclusion. .
    Abstract: This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described. In turn, the various aspects of bacterial physiology affected by these signaling systems– e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis – are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior. Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions.
    Type of Medium: Online Resource
    Pages: XVIII, 657 p. 108 illus., 96 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030333089
    DDC: 579.3
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical sciences. ; Statistics . ; Social sciences. ; Humanities. ; Biomedical Research. ; Health Sciences. ; Statistics. ; Humanities and Social Sciences.
    Description / Table of Contents: Preface -- Section I Cluster and Classification Models -- Hierarchical Clustering and K-means Clustering to Identify Subgroups in Surveys (50 Patients) -- Density-based Clustering to Identify Outlier Groups in Otherwise Homogeneous Data (50 Patients) -- Two Step Clustering to Identify Subgroups and Predict Subgroup Memberships in Individual Future Patients (120 Patients) -- Nearest Neighbors for Classifying New Medicines (2 New and 25 Old Opioids) -- Predicting High-Risk-Bin Memberships (1445 Families) -- Predicting Outlier Memberships (2000 Patients) -- Data Mining for Visualization of Health Processes (150 Patients) -- Trained Decision Trees for a More Meaningful Accuracy (150 Patients) -- Typology of Medical Data (51 Patients) -- Predictions from Nominal Clinical Data (450 Patients) -- Predictions from Ordinal Clinical Data (450 Patients) -- Assessing Relative Health Risks (3000 Subjects) -- Measurement Agreements (30 Patients) -- Column Proportions for Testing Differences between Outcome Scores (450 Patients) -- Pivoting Trays and Tables for Improved Analysis of Multidimensional Data (450 Patients) -- Online Analytical Procedure Cubes for a More Rapid Approach to Analyzing Frequencies (450 Patients) -- Restructure Data Wizard for Data Classified the Wrong Way (20 Patients) -- Control Charts for Quality Control of Medicines (164 Tablet Desintegration Times) -- Section II (Log) Linear Models -- Linear, Logistic, and Cox Regression for Outcome Prediction with Unpaired Data (20, 55, and 60 Patients) -- Generalized Linear Models for Outcome Prediction with Paired Data (100 Patients and 139 Physicians) -- Generalized Linear Models for Predicting Event-Rates (50 Patients) -- Factor Analysis and Partial Least Squares (PLS) for Complex-Data Reduction (250 Patients) -- Optimal Scaling of High-sensitivity Analysis of Health Predictors (250 Patients) -- Discriminant Analysis for Making a Diagnosis from Multiple Outcomes (45 Patients) -- Weighted Least Squares for Adjusting Efficacy Data with Inconsistent Spread (78 Patients) -- Partial Correlations for Removing Interaction Effects from Efficacy Data (64 Patients) -- Canonical Regression for Overall Statistics of Multivariate Data (250 Patients) -- Multinomial Regression for Outcome Categories (55 Patients) -- Various Methods for Analyzing Predictor Categories (60 and 30 Patients) -- Random Intercept Models for Both Outcome and Predictor Categories (55 Patients) -- Automatic Regression for Maximizing Linear Relationships (55 Patients) -- Simulation Models for Varying Predictors (9000 Patients) -- Generalized Linear Mixed Models for Outcome Prediction from Mixed Data (20 Patients) -- Two Stage Least Squares for Linear Models with Problematic Predictors (35 Patients) -- Autoregressive Models for Longitudinal Data (120 Monthly Population Records) -- Variance Components for Assessing the Magnitude of Random Effects (40 Patients) -- Ordinal Scaling for Clinical Scores with Inconsistent Intervals (900 Patients) -- Loglinear Models for Assessing Incident Rates with Varying Incident Risks (12 Populations) -- Loglinear Models for Outcome Categories (445 Patients) -- More on Polytomous Outcome Regressions (450 Patients) -- Heterogeneity in Clinical Research: Mechanisms Responsible (20 Studies) -- Performance Evaluation of Novel Diagnostic Tests (650 and 588 Patients) -- Quantile - Quantile Plots, a Good Start for Looking at Your Medical Data (50 Cholesterol Measurements and 52 Patients) -- Rate Analysis of Medical Data Better than Risk Analysis (52 Patients) -- Trend Tests Will Be Statistically Significant if Traditional Tests Are not (30 and 106 Patients) -- Doubly Multivariate Analysis of Variance for Multiple Observations from Multiple Outcome Variables (16 Patients) -- Probit Models for Estimating Effective Pharmacological Treatment Dosages (14 Tests) -- Interval Censored Data Analysis for Assessing Mean Time to Cancer Relapse (51 Patients) -- Structural Equation Modeling with SPSS Analysis of Moment Structures (Amos) for Cause Effect Relationships I (35 Patients) -- Structural Equation Modeling with SPSS Analysis of Moment Structures (Amos) for Cause Effect Relationships II (35 Patients) -- Firth's Bias-adjusted Estimates for Biased Logistic Data Models (23 Challenger launchings) -- Omics Research (125 Patients, 24 Predictor Variables) -- Sparse Canonical Correlation Analysis (12209 Genes in 45 Glioblastoma Carriers) -- Eigenvalues, Eigenvectors and Eigenfunctions (45 and 250 Patients) -- Section III Rules Models -- Neural Networks for Assessing Relationships that are Typically Nonlinear (90 Patients) -- Complex Samples Methodologies for Unbiased Sampling (9,678 Persons) -- Correspondence Analysis for Identifying the Best of Multiple Treatments in Multiple Groups (217 Patients) -- Decision Trees for Decision Analysis (1004 and 953 Patients) -- Multidimensional Scaling for Visualizing Experienced Drug Efficacies (14 Pain-killers and 42 Patients) -- Stochastic Processes for Long Term Predictions from Short Term Observations -- Optimal Binning for Finding High Risk Cut-offs (1445 Families) -- Conjoint Analysis for Determining the Most Appreciated Properties of Medicines to Be Developed (15 Physicians) -- Item Response Modeling for Analyzing Quality of Life with Better Precision (1000 Patients) -- Survival Studies with Varying Risks of Dying (50 and 60 Patients) -- Fuzzy Logic for Improved Precision of Pharmacological Data Analysis (9 Induction Dosages) -- Automatic Data Mining for the Best Treatment of a Disease (90 Patients) -- Pareto Charts for Identifying the Main Factors of Multifactorial Outcomes (2000 Admissions to Hospital) -- Radial Basis Neural Networks for Multidimensional Gaussian Data (90 persons) -- Automatic Modeling for Drug Efficacy Prediction (250 Patients) -- Automatic Modeling for Clinical Event Prediction (200 Patients) -- Automatic Newton Modeling in Clinical Pharmacology (15 Alfentanil dosages, 15 Quinidine time-concentration relationships) -- Spectral Plots for High Sensitivity Assessment of Periodicity (6 Years’ Monthly C Reactive Protein Levels) -- Runs Test for Identifying Best Analysis Models (21 Estimates of Quantity and Quality of Patient Care) -- Evolutionary Operations for Health Process Improvement (8 Operation Room Settings) -- Bayesian Networks for Cause Effect Modeling (600 Patients) -- Support Vector Machines for Imperfect Nonlinear Data (200 Patients) -- Multiple Response Sets for Visualizing Clinical Data Trends (811 Patient Visits) -- Protein and DNA Sequence Mining -- Iteration Methods for Crossvalidation (150 Patients) -- Testing Parallel-groups with Different Sample Sizes and Variances (5 Parallel-group Studies) -- Association Rules between Exposure and Outcome (50 and 60 Patients) -- Confidence Intervals for Proportions and Differences in Proportions (100 and 75 Patients) -- Ratio Statistics for Efficacy Analysis of New Drugs 50 Patients) -- Fifth Order Polynomes of Circadian Rhythms (1 Patient) -- Gamma Distribution for Estimating the Predictors of Medical Outcomes (110 Patients) -- Index.
    Abstract: Adequate health and health care is no longer possible without proper data supervision from modern machine learning methodologies like cluster models, neural networks, and other data mining methodologies. The current book is the first publication of a complete overview of machine learning methodologies for the medical and health sector, and it was written as a training companion, and as a must-read, not only for physicians and students, but also for any one involved in the process and progress of health and health care. In this second edition the authors have removed the textual errors from the first edition. Also, the improved tables from the first edition, have been replaced with the original tables from the software programs as applied. This is, because, unlike the former, the latter were without error, and readers were better familiar with them. The main purpose of the first edition was, to provide stepwise analyses of the novel methods from data examples, but background information and clinical relevance information may have been somewhat lacking. Therefore, each chapter now contains a section entitled "Background Information". Machine learning may be more informative, and may provide better sensitivity of testing than traditional analytic methods may do. In the second edition a place has been given for the use of machine learning not only to the analysis of observational clinical data, but also to that of controlled clinical trials. Unlike the first edition, the second edition has drawings in full color providing a helpful extra dimension to the data analysis. Several machine learning methodologies not yet covered in the first edition, but increasingly important today, have been included in this updated edition, for example, negative binomial and Poisson regressions, sparse canonical analysis, Firth's bias adjusted logistic analysis, omics research, eigenvalues and eigenvectors. .
    Type of Medium: Online Resource
    Pages: XXX, 667 p. 548 illus., 131 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030339708
    DDC: 610.72
    Language: English
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  • 79
    Keywords: Medical microbiology. ; Parasitology. ; Microbiology. ; Medicine Research. ; Biology Research. ; Medical Microbiology. ; Parasitology. ; Microbiology. ; Biomedical Research.
    Description / Table of Contents: Eukaryome: Emerging field with profound translational potential -- Resolving amoebozoan encystation from Dictyostelium evo-devo and amoebozoan comparative genomics -- Integrative omics analysis of the effect of bacteria on the resistance of Entamoeba histolytica to oxidative stress -- Histomonas meleagridis molecular traits –from past to future -- Exploring the biology and evolution of Blastocystis and its role in the microbiome -- Advances in the study of Blastocystis spp. in Mexico: prevalence, genetic diversity, clinical association and their possible role in the human intestine -- Cryptosporidium infection in Bangladesh children -- The current molecular epidemiological scenario of Cryptosporidium, Giardia and Blastocystis in Spain. Implication for public health -- The protozoome of the periodontal sulcus: from health to disease -- Tritrichomonas spp. and Their Impact on Gut Immune Homeostasis -- Contribution of host immunity to the development of Entamoeba histolytica-induced liver abscess -- Oxidative Stress And Heat Stress In Experimental Amoebic Liver Abscess -- Role of Extracellular Traps promoted by intestinal parasites. Relationship with virulence -- Parasite secretory molecules in host-parasite interaction -- The Role of Host PKCα during Intracellular Cryptosporidium Infection -- Immune response triggered by Entamoeba histolytica in a 3D-intestinal model -- Receptors for phagocytosis and trogocytosis in Entamoeba histolytica -- PtdIns(3,4,5)P3 binding protein screening reveals unique molecules involved in endocytic processes -- Molecular insights into E. histolytica mediated host tissue invasion -- Vesicular trafficking in Entamoeba histolytica is essential for its virulence -- MOLECULAR CHARACTERIZATION OF Entamoeba histolytica tRNA GENES -- Gene silencing and overexpression to study pathogenicity factors of Entamoeba histolytica -- Polyadenylation machineries in intestinal parasites: latest advances in the protozoan parasite Entamoeba histolytica -- Probiotics as anti-Giardia defenders: Overview on putative control mechanisms -- A protocol to quantify cellular morphodynamics: from cell labelling to automatic image analysis.-.
    Abstract: The intestine is home to diverse bacterial communities forming the microbiome that influences host nutrition, immune functions and health. DNA-based methods have been instrumental to gain insight into the microbial eukaryotic diversity of the human gut. For instance, the microbiome share the intestinal ecosystem with a population of uni- and multi-cellular eukaryotic organisms. These eukaryotic organisms are very common and often very abundant in individuals with intestinal healthy conditions as well as those with intestinal diseases. The impact of the relationship between bacterial and eukaryotic organisms within the intestinal ecosystem on homeostasis and intestinal diseases is limited and can be considered an important emerging field of research. In addition, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called “intestinal eukaryome”, that include fungi, protists and helminths. All these organisms and their interplay with bacteria and the human immune system are a challenge to assess the impact (present and future) of intestinal infectious diseases on public health. This book presents an overview of the science presented and discussed in the First Eukaryome Congress, held from October 16th to 18th, 2019 at Pasteur Institute in Paris, France. This contributed volume is of special interest for PhD students, postdoctoral fellows, researchers and clinicians interested in the effect of the eukaryotic microbiome on human health.
    Type of Medium: Online Resource
    Pages: XVII, 367 p. 60 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030448264
    DDC: 616.9041
    Language: English
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  • 80
    Keywords: Biotechnology. ; Regenerative medicine. ; Pharmaceutical chemistry. ; Neurosciences. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Pharmaceutics. ; Neuroscience. ; Chemical Bioengineering.
    Description / Table of Contents: Part I. Novel Bioinspired Biomaterials for Regenerative Medicine -- Chapter 1. Natural Sources and Applications of Demineralized Bone Matrix in the Field of Bone and Cartilage Tissue Engineering -- Chapter 2. Application of Gellan Gum-based Scaffold for Regenerative Medicine -- Chapter 3. Natural Fibrous Protein for Advanced Tissue Engineering Applications: Focusing on Silk Fibroin and Keratin -- Part II. Bioinspired 3D Bioprinting Hydrogel for Regenerative Medicine -- Chapter 4. Silk Fibroin Bioinks for Digital Light Processing (DLP) 3D Bioprinting -- Chapter 5. 3D-Bioprinting of Tissue Models with Customized Bioinks -- Chapter 6. Visible Light-curable Hydrogel Systems for Tissue Engineering and Drug Delivery -- Part III. Regulation of Stem Cell Fate by Bioinspired Biomaterials -- Chapter 7. Scaffolds for Cartilage Regeneration: To Use or Not to Use -- Chapter 8. Bio-application of Inorganic Nanomaterials in Tissue Engineering -- Chapter 9. Directional Cell Migration Guide for Improved Tissue Regeneration -- Part IV. Cutting-Edge Enabling Technology for Regenerative Medicine -- Chapter 10. Extracellular Vesicles: The Next Frontier in Regenerative Medicine and Drug Delivery -- Chapter 11. Application of Tissue Engineering and Regenerative Medicine in Maternal-fetal Medicine -- Chapter 12. Fundamentals and Current Strategies for Peripheral Nerve Repair and Regeneration -- Chapter 13. Protein-based Drug Delivery in Brain Tumor Therapy -- Chapter 14. Human Hair: Scaffold Materials for Regenerative Medicine.
    Abstract: This book is the first of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. Topics addressed in this volume, which is devoted to bioinspired biomaterials, range from novel biomaterials for regenerative medicine through to emerging enabling technologies with applications in, for example, drug delivery, maternal–fetal medicine, peripheral nerve repair and regeneration, and brain tumor therapy. New bioinspired hydrogels receive detailed attention in the book, and a further focus is the use of bioinspired biomaterials in the regulation of stem cell fate. Here the coverage includes the role of scaffolds in cartilage regeneration, the bioapplication of inorganic nanomaterials in tissue engineering, and guidance of cell migration to improve tissue regeneration. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials. .
    Type of Medium: Online Resource
    Pages: X, 229 p. 45 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811532580
    Series Statement: Advances in Experimental Medicine and Biology, 1249
    DDC: 660.6
    Language: English
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  • 81
    Keywords: Biotechnology. ; Regenerative medicine. ; Pharmaceutical chemistry. ; Neurosciences. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Pharmaceutics. ; Neuroscience. ; Chemical Bioengineering.
    Description / Table of Contents: Part I. Novel Biomimicked Biomaterials for Regenerative Medicine -- Chapter 1. Bone Regeneration using Duck’s Feet Derived Collagen Scaffold as an Alternative Collagen Source -- Chapter 2. Decellularized Extracellular Matrices for Tissue Engineering and Regeneration -- Part II. Novel Biomimicked Hydrogel for Regenerative Medicine -- Chapter 3. Injectable in situ-forming Hydrogels for Protein and Peptide Delivery -- Chapter 4. Alginate Hydrogels as 3D Cell Encapsulation Matrices for Tissue Engineering and Regenerative Medicine -- Chapter 5. Design of Advanced Polymeric Hydrogels for Tissue Regenerative Medicine: Oxygen-controllable Hydrogel Materials -- Chapter 6. Enhancing Osteochondral Tissue Regeneration of Gellan Gum by Incorporating Gallus Gallus var Domesticus Derived Demineralized Bone Particle -- Part III. Control of Stem Cell Fate by Biomaterials for Regenerative Medicine -- Chapter 7. The Development of Extracellular Vesicles-Integrated Biomaterials for Bone Regeneration -- Chapter 8. In vivo Evaluation of the Biocompatibility of Biomaterial Device -- Chapter 9. Cell Response to Materials for Biomedical Engineering -- Chapter 10. Regulation of Stem Cell Functions by Micro-patterned Structures -- Part IV. Nano-Intelligent Biocomposites for Regenerative Medicine -- Chapter 11. Natural Polyphenols as Modulators of the Fibrillization of Islet Amyloid Polypeptide -- Chapter 12.Recent Advances of Biphasic Calcium Phosphate Bioceramics for Bone Tissue Regeneration -- Chapter 13. Surface-modifying Polymers for Blood-Contacting Polymeric Biomaterials.
    Abstract: This book is the second of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. In this volume, which is devoted to biomimetic biomaterials, the opening section discusses bone regeneration by means of duck’s feet-derived collagen scaffold and the use of decellularized extracellular matrices. The role of various novel biomimetic hydrogels in regenerative medicine is then considered in detail. The third section focuses on the control of stem cell fate by biomimetic biomaterials, covering exosome-integrated biomaterials for bone regeneration, cellular responses to materials for biomedical engineering, and the regulation of stem cell functions by micropatterned structures. Finally, the use of nano-intelligent biocomposites in regenerative medicine is addressed, with discussion of, for example, recent advances in biphasic calcium phosphate bioceramics and blood-contacting polymeric biomaterials. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.
    Type of Medium: Online Resource
    Pages: X, 198 p. 60 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811532627
    Series Statement: Advances in Experimental Medicine and Biology, 1250
    DDC: 660.6
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Immunology. ; Medical microbiology. ; Molecular genetics. ; Stem cells. ; Cell death. ; Cancer Biology. ; Immunology. ; Medical Microbiology. ; Molecular Genetics. ; Stem Cell Biology. ; Cell Death.
    Description / Table of Contents: Chapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy – An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.
    Abstract: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
    Type of Medium: Online Resource
    Pages: VII, 280 p. 38 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811569302
    DDC: 571.978
    Language: English
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  • 83
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Cytology. ; Nanoscience. ; Biotechnology. ; Cell Biology. ; Nanophysics.
    Description / Table of Contents: Chapter 1: Introduction: Fluorescent materials for cell imaging -- Chapter 2: Semiconductor quantum dots for cell imaging -- Chapter 3: Carbon nanodots for cell imaging -- Chapter 4: Silicon nanoparticles for cell imaging -- Chapter 5: Fluorescent metal nanoclusters for bioimaging -- Chapter 6: Lanthanide-based upconversion nanoparticles for bioimaging applications -- Chapter 7: Conjugated polymers and polymer dots for cell imaging -- Chapter 8: Aggregation-induced emission (AIE) probes for cell imaging -- Chapter 9: Luminescent coordination compounds for cell imaging.
    Abstract: This book focuses on the latest fluorescent materials for cell imaging. Cell imaging is a widely used basic technique that helps scientists gain a better understanding of biological functions through studies of cellular structure and dynamics. In the past decades, the development of a variety of new fluorescent materials has significantly extended the applications of cellular imaging techniques. This book presents recently developed fluorescent materials, including semiconductor quantum dots, carbon dots, silicon nanoparticles, metal nanoclusters, upconversion nanoparticles, conjugated polymers/polymer dots, aggregation-induced emission (AIE) probes, and coordination compounds, used for various cellular imaging purposes. It will appeal to cell biologists and other researchers in academia, industry and clinical settings who are interested in the technical development and advanced applications of fluorescence imaging in cells, tissues and organisms to explore the mechanisms of biological functions and diseases.
    Type of Medium: Online Resource
    Pages: V, 247 p. 140 illus., 128 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811550621
    DDC: 660.6
    Language: English
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  • 84
    Keywords: Fungi. ; Mycology. ; Microbiology. ; Plant biotechnology. ; Renewable energy sources. ; Biology Technique. ; Plant diseases. ; Fungi. ; Plant Biotechnology. ; Microbiology. ; Renewable Energy. ; Biological Techniques. ; Plant Pathology.
    Description / Table of Contents: Preface -- Biofuels: challenges and the promises of fungi in biofuel production -- Plant pathogenic fungi for bioethanol production: mechanisms of actions -- Plant pathogenic fungi for biodiesel production -- Plant pathogenic fungi for VOCs production -- Plant probiotic fungi as a new source for Bioethanol Production -- Endophytic fungi for biofuel production -- Brown and white rot fungi for biofuel production -- Gut fungi for biofuel production -- Consolidated bioprocessing: highly efficient fungi for biofuel production -- Process design in fungal-based biofuel production systems -- Life cycle assessment (LCA) of fungal-based biofuel production systems -- Thermodynamics aspects of fungal-based biofuel production systems -- Modeling and optimization to enhance fungal-based biofuel production -- Index.
    Abstract: Due to the huge quantity and diverse nature of their metabolic pathways, fungi have great potential to be used for the production of different biofuels such as bioethanol, biobutanol, and biodiesel. This book presents recent advances, as well as challenges and promises, of fungal applications in biofuel production, subsequently discussing plant pathogenic fungi for bioethanol and biodiesel production, including their mechanisms of action. Additionally, this book reviews biofuel production using plant endophytic fungi, wood-rotting fungi, fungal biocontrol agents, and gut fungi, and it investigates highly efficient fungi for biofuel production and process design in fungal-based biofuel production systems. Finally, life cycle assessment of fungal-based biofuel production systems are discussed in this volume.
    Type of Medium: Online Resource
    Pages: XI, 233 p. 35 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030444884
    Series Statement: Fungal Biology,
    DDC: 579.5
    Language: English
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  • 85
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Life sciences. ; Ecology . ; Environment. ; Agriculture. ; Pharmacology. ; Life Sciences. ; Ecology. ; Environmental Sciences. ; Agriculture. ; Pharmacology.
    Description / Table of Contents: 1. What is the problem? Pesticides in our everyday life -- 2. Pesticide impacts on the environment, and humans -- 3. Where are the solutions to the pesticide problem?
    Abstract: This book is a sound science report about the consequences of pesticides to nature, health and environment. The book shares essential insights into the use of pesticides in agriculture, discusses the politics, rhetoric and profits involved, addresses the potential health and ecological risks of pesticides in our daily lives, and debates possible solutions. Is agriculture without pesticides possible at all? Moreover, the author gives insight into his scientific work, the set-up of the experiments, and also writes about his very own experiences with the media and press after publication of his studies. For many years, Johann G. Zaller, an ecologist at the University of Natural Resources and Life Sciences in Vienna, and his team, have been researching applied chemicals and their effects on the environment. Their findings, together with relevant literature and media reports, are presented in this book, which offers a unique resource for anyone who wants to know the nature and background of pesticides and how we come into contact with them in our daily lives. Ever ate an apple? Read this book!
    Type of Medium: Online Resource
    Pages: XV, 305 p. 9 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030505301
    DDC: 570
    Language: English
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  • 86
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Pharmacy. ; Medical sciences. ; Drug development. ; Pharmacology. ; Pharmacy. ; Preclinical Research.
    Description / Table of Contents: Chapter 1. Introduction to mammalian circadian clock system -- Chapter 2. Introduction to pharmacokinetics -- Chapter 3. Circadian clock and metabolic diseases -- Chapter 4. Circadian clock and CYP metabolism -- Chapter 5. Circadian clock and non-CYP phase I metabolism -- Chapter 6. Circadian clock and phase II metabolism -- Chapter 7. Circadian clock and uptake transporters -- Chapter 8. Circadian clock and efflux transporters -- Chapter 9. Role of pharmacokinetics in chronotherapeutics -- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.
    Abstract: This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.
    Type of Medium: Online Resource
    Pages: VII, 253 p. 59 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811588075
    DDC: 615
    Language: English
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  • 87
    Keywords: Botanical chemistry. ; Microbiology. ; Environmental chemistry. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Environmental management. ; Plant Biochemistry. ; Microbiology. ; Environmental Chemistry. ; Environmental Engineering/Biotechnology. ; Environmental Management.
    Description / Table of Contents: Chapter 1. Impact of fermentation types on enzymes used for biofuels production -- Chapter 2. Downstream Processing; Applications and Recent Updates -- Chapter 3. Role of bioreactors in bio-fuel generations -- Chapter 4. Bioprocess for Algal Biofuels Production -- Chapter 5. Effect of Bioprocess Parameters on Biofuel Production -- Chapter 6. Role of substrate to improve biomass to bio fuel production technologies -- Chapter 7. Techno-economic analysis of second-generation bio-fuel technologies -- Chapter 8. Recent advances in metabolic engineering and synthetic biology for microbial production of isoprenoid-based biofuels: an overview -- Chapter 9. Applications of biosensors for metabolic engineering of microorganisms and its impact on biofuel production -- Chapter 10. Recent progress in CRISPR-based technologies applications for biofuels production.
    Abstract: Converting biomass to biofuels involves hydrolyzing cellulose to sugars using cost-intensive commercial enzymes – an expensive step that makes large-scale production economically non-viable. As such, there is a need for low-cost bioprocessing. This book critically evaluates the available bioprocessing technologies for various biofuels, and presents the latest research in the field. It also highlights the recent developments, current challenges and viable alternative approaches to reduce the overall cost of producing biofuels.
    Type of Medium: Online Resource
    Pages: XII, 231 p. 53 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811570704
    Series Statement: Clean Energy Production Technologies,
    DDC: 572.2
    Language: English
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  • 88
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotic communities. ; Biodiversity. ; Plant ecology. ; Animal migration. ; Ecosystems. ; Biodiversity. ; Plant Ecology. ; Animal Migration.
    Description / Table of Contents: 1. Introduction: Randall W. Myster -- 2. Dynamics of Andean Treeline Ecotones: Between Cloud Forest and Páramo Geocritical Tropes. Fausto O. Sarmiento -- 3. ANÁLISIS REGIONAL EN ECOSISTEMAS DE MONTAÑA EN COLOMBIA:Una mirada desde la funcionalidad del paisaje y los servicios ecosistémicos. Paola Isaacs-Cubides, Julián Díaz and Tobias Leyva-Pinto -- 4. Ecohydrology of Tropical Andean Cloud Forests. Conrado Tobon Martin -- 5. Litterfall in Andean forests: Quantity, composition, and environmental drivers. Wolfgang Wilcke -- 6. Arbuscular Mycorrhizal Fungi and Ectomycorrhizas in the Andean Cloud Forest of South Ecuador. Ingeborg Haug, Sabrina Setaro, Juan Pablo Suárez -- 7. Nesting ecology of the Tucuman Amazon (Amazona tucumana) in the cloud forest of Northwestern Argentina. Luis Rivera and Natalia Politi -- 8. Adaptive strategies of frugivore bats to Andean cloud forests. Adriana Ruiz and Pascual J. Soriano -- 9. Diversification and dispersal of Neotropical fauna: Processes and patterns in Andean species diversity. Juan C. Garcia-Ramirez and Angela M. Mendoza-Henao -- 10. Mapping Hydrological Ecosystem Services and Impacts of Scenarios for Deforestation and Conservation of Lowland, Montane and Cloud-Affected Forests. Mark Mulligan -- 11. Randall W. Myster. Conclusions, synthesis and future directions.
    Abstract: A book focused solely on Andean Cloud Forests (ACF) has never been published. ACF are high biodiversity ecosystems in the Neotropics with a large proportion of endemic species, and are important for the hydrology of entire regions. They provide water for large parts of the Amazon basin, for example. Here I take advantage of my many years working in ACF in Ecuador, to edit this book that contains the following sections: (1) ACF over space and time, (2) Hydrology, (3) Light and the Carbon cycle, (4) Soil, litter, fungi and nutrient cycling, (5) Plants, (6) Animals, and (7) Human impacts and management. Under this premise, international experts contributed chapters that consist of reviews of what is known about their topic, of what research they have done, and of what needs to be done in the future. This work is suitable for graduate students, professors, scientists, and researcher-oriented managers.
    Type of Medium: Online Resource
    Pages: X, 223 p. 61 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030573447
    DDC: 577
    Language: English
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  • 89
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Proteins. ; Proteins.
    Description / Table of Contents: The Degron Architecture of Squalene Monooxygenase and How Specific Lipids Calibrate Levels of This Key Cholesterol Synthesis Enzyme -- Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology -- Collagen IV Exploits a Cl- Step Gradient for Scaffold Assembly -- Roles of Slit Ligands and Their Roundabout (Robo) Family of Receptors in Bone Remodeling -- Characterization of C. elegans Chondroitin Proteoglycans and Their Large Functional and Structural Heterogeneity; Evolutionary Aspects on Structural Differences Between Humans and the Nematode- Structural Basis of a Conventional Recognition Mode of IGHV1-69 Rheumatoid Factors -- Regulated Alternative Translocation: A Mechanism Regulating Transmembrane Proteins Through Topological Inversion- Interleukin-36: Structure, Signaling and Function.
    Abstract: The Protein Reviews series serves as a publication vehicle for reviews that focus on crucial contemporary and vital aspects of protein structure, function, evolution and genetics. Volumes are published online first, prior to publication in a printed book. Chapters are selected according to their importance to the understanding of biological systems, relevance to the unravelling of issues associated with health and disease, or impact on scientific or technological advances and developments. Volume 21 presents eight review chapters authored by experts in the related fields. The first chapter covers the enzyme squalene monooxygenase and lipid levels and its relevance in health and disease. Chapter two presents a systematic analysis of the structural and functional aspects of heteromeric solute carriers. The third chapter provides a review of the role of CI- in type IV collagen assembly, function, and disease, including future directions for studies. This is followed by a summary in chapter four about the recent progress on defining the roles of the Slit-Robo signaling in bone metabolism and the possible roles of the interaction between Robo and neural epidermal growth factor-like proteins. Chapter five discusses recent data about the evolutionary aspects on structural differences between humans and the nematode in relation to previous knowledge of core proteins and GAG-attachment sites in Chn and CS proteoglycans of C.elegans and humans. The sixth chapter summarizes the immunochemical character of the IGHV1-69-derived RFs and the recognition mechanism of the IGHV1-69-derived RFs. Chapter seven covers regulated alternative translocation and its role as an emerging mechanism to regulate transmembrane proteins. Finally, chapter eight reviews current progress on IL-36 protein and biology and novel investigative tools. This volume is intended for research scientists, clinicians, physicians and graduate students in the fields of biochemistry, cell biology, molecular biology, immunology and genetics. .
    Type of Medium: Online Resource
    Pages: VII, 213 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030678142
    Series Statement: Protein Reviews, 21
    DDC: 572.6
    Language: English
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  • 90
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Animal culture. ; Embryology. ; Veterinary medicine. ; Microfluidics. ; Animal Science. ; Embryology. ; Veterinary Science. ; Microfluidics.
    Description / Table of Contents: Chapter 1. Introduction to Microfluidics and animal reproductive techniques -- Chapter 2. Principles, materials and fabrication methods of microfluidics -- Chapter 3. Microfluidics and non-microfluidics methods of sperm sorting and sperm analysis -- Chapter 4. Applications of microfluidcs for in vitro fertilization and embryo Culture -- Chapter 5. Microlfuidics in cryoreservation of animal gametes and embryos -- Chapter 6. New hope for sperm sexing: possible role of microfluidics.
    Abstract: This book describes the fundamentals of microfluidics and fabrication methods of microfluidic devices that can be adopted for animal-assisted reproduction. It presents microfluidic methods for sorting highly fertile spermatozoa. This book also describes the application of microfluidics in vitro fertilization and embryo culture. It discusses the use of microfluidics in sperm sexing and the cryopreservation of animal gametes and embryos. Lastly, the book examines the potential opportunities of microfluidics in infertility diagnosis, sperm selection and guidance, oocyte selection, insemination, and embryo monitoring.
    Type of Medium: Online Resource
    Pages: XVII, 109 p. 31 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813348769
    DDC: 636
    Language: English
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  • 91
    Keywords: Life sciences. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Genetics. ; Bioinformatics. ; Biomedical engineering. ; Life Sciences. ; Biomedical Research. ; Biotechnology. ; Genetics and Genomics. ; Computational and Systems Biology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Introduction -- Epigenetics in Leukemia -- Genetic and Epigenetic Alterations in Leukemia -- Epigenetic Modifiers and Their Inhibitors in Leukemia Treatment -- Chromatin Remodeling during Leukemia Cell Proliferation and Differentiation -- DNA Methylation and Epigenetic Regulation -- Chromatin Functional Regulation by Histone Modification -- Approaches to Epigenetic Treatment of Leukemia -- Proteomics in Leukemia -- Proteome in Leukemic vs. Differentiated Leukemia Cells -- Protein Phosphorylation in Leukemia -- Computational Methods for Proteome Analysis -- 2DE Fractionation and Visualization -- Proteomic Data Processing -- Proteomic Data Analysis -- Image Acquisition and Data Analysis -- Image Acquisition and Data Analysis -- Protein Localization in Leukemia -- Protein Translocation into the Nucleus during Leukemia Cell Differentiation -- Protein Visualization in Leukemic Cells -- Computational Methods for Protein Localization Estimation -- Fluorescent Image Processing -- Fluorescent Image Acquisition and Analysis -- Future Therapy in Leukemia -- Index.
    Abstract: This book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy. Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.
    Type of Medium: Online Resource
    Pages: LIX, 406 p. 156 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030687083
    DDC: 570
    Language: English
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  • 92
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biology. ; Zoology. ; Cognition in animals. ; Neurosciences. ; Physiology. ; Psychology. ; Biological Sciences. ; Zoology. ; Animal Cognition. ; Neuroscience. ; Animal Physiology. ; Behavioral Sciences and Psychology.
    Description / Table of Contents: Preface -- The struggle for insight -- How research on honeybee communication began -- Research on Bees Flourishes with Karl von Frisch -- The dance language remains a controversial idea -- James L. Gould’s experiments explain some but not all difficulties -- Research focuses on the inside of the hive -- Measurement of the dance figures in Space and Time -- Bees and vectors -- Robo-bees and radar techniques -- An interim balance sheet -- Swarm behaviour shows bees communicate not only through the dance -- Rethinking communication between bees -- Conclusion -- Appendix.
    Abstract: How Do Bees Find Flowers? During the history of bee research, scientists have peered deep into the inner life of bee colonies and learned much about the behaviour of these insects. Above all, the bee waggle dance has become a famous and extensively discussed phenomenon. Nevertheless, recent insights reveal that while bees are social insects inside the hive they also communicate with one another outside the hive. In this book, Jürgen Tautz, renowned German bee researcher, provides an entertaining, fresh and enlightened account for lay and professional readers, not only about the fascinating dance language but also about additional remarkable phenomena concerning information exchange between bees.
    Type of Medium: Online Resource
    Pages: XI, 165 p. 67 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030994846
    DDC: 570
    Language: English
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  • 93
    Keywords: Biotechnology. ; Early childhood education. ; Communication. ; Biotechnology. ; Early Childhood Education. ; Media and Communication.
    Description / Table of Contents: Chapter 1. Introduction (Karen Murcia) -- Part I: The Early Childhood Home. Chapter 2. “The Tablet is my Best Friend!”: Practices and Perceptions of Young Children and Their Parents (Patricia Dias) -- Chapter 3. Family Mediating Practices and Ideologies: Spanish and Portuguese Parents of Children Under Three and Digital Media in Homes (Mitsuko Matsumoto) -- Chapter 4. Digital Parenting and Transnational Migration: Cultural and Emotional Drives for Digital Media Use (Teresa Castro) -- Chapter 5. Children’s Rights To ‘Good’ and ‘Bad’ Screen Time: Parental Narratives of how Children do Family Online (Helga Sadowski) -- Chapter 6. Taking Over the Home: Children's Mobile Media Play in Domestic Space (Will Balmford) Chapter 7. Think of the Parents: Parental Controls in Digital TV and Family Implications (Maureen Mauk) -- Chapter 8. Screening Language Acquisition Skills in a Mediated Childhood (Kylie Stevenson) -- Part II: Learning and Teaching -- Chapter 9. Media Arts in Early Childhood: A Framework for Developing Young Children’s Creative Participation in the Digital World (Judith Dinham) -- Chapter 10. The Impact of Digital Technologies on the Role of the Early Childhood Teacher (Vicki Schriever) -- Chapter 11. Bridging Communities: Developing Digital Literacies and Introducing Digital Technologies in the Montessori Early Childhood Education Classroom (Samantha Owen) -- Chapter 12. Understanding the Mutuality of Play and Media Literacy in Young Children: An Ethnographic Investigation of Pre-Primary School Children’s Perspectives on Media Literacy as Seen Through the Lens of Play (Helle Hovgaard Jørgensen) -- Chapter 13. Digital Technologies and Children: Does more Digital Interactivity make for Better Learning? (Jo Li Marie-Joelle Tay) -- Chapter 14. Disability and Remote Learning During COVID-19 (Katie Ellis) -- Part III: Connected Toys at Home and School -- Chapter 15. Internet of Toys and Forms of Play Early Education: A Longitudinal Study of Preschoolers’ Toy-Based Learning Experiences (Pirita Ihamäki) -- Chapter 16. Digital Play Objects as Part of Preschool Children’s Imaginative Play (Kristín Dýrfjörð) -- Chapter 17. Co-Creating Hybrid Toys as an Approach to Understand Children’s Needs in Play Experience (Tamara Pinos Cisneros) -- Chapter 18. Assessing Developmental Difficulties in Children Through Connected Smart Toys (Diego Rivera) -- Chapter 19. Young Children Learning to Code: A Digital Technologies Framework for the Early Years (Karen Murcia) -- Part IV: Privacy and Protection -- Chapter 20. Researching Representations of Children and Childhood on Instagram: Ethical and Methodological Considerations (Madeleine Dobson) -- Chapter 21. The “Sharent” Trap: Parenting in the Digital Age and a Child’s Right to Privacy (Anna Potter) -- Chapter 22. Santa’s Little Helper and Star of Instagram, Elf on the Shelf: Gendered Labour; Normalising Surveillance and Digitising a Childhood Phenomenon (Catherine Archer) -- Chapter 23.Digital Predictions: Children's Futures, Opportunities and Obstacles (Michele Willson) -- Chapter 24. Research Ethics and Digitising Early Childhood (Madeleine Dobson).
    Abstract: This volume focuses on very young children’s (aged 0-8) rights in a digital world. It gathers current research from around the globe that focuses on young children’s rights as agental citizens to the provision of and participation in digital devices and content—as well as their right to protection from harm. The UN Digital Rights Framework of 2014 addresses children’s needs, agency and vulnerability to harm in today’s digital world and implies roles and responsibilities for a variety of social actors including the state, families, schools, commercial entities, researchers and children themselves. This volume presents a broad range of research, including chapters on parental supervision and control, the changing forms of play, early childhood education, media and cultural studies, law, design, health, special-needs education, and engineering. Implicit within this book is the acknowledgement that children of various ages, abilities, socioeconomic and geographic backgrounds should have equal access to, and positive / non-harmful experiences with, new digital technologies and content—as well as adult support and expertise that enhances these experiences. This wonderful book has global relevance, balancing children’s embrace of digital content with adult responsibilities for education, privacy and protection. Professor Lelia Green, Professor of Communications, Edith Cowan University, Perth, Western Australia.
    Type of Medium: Online Resource
    Pages: XV, 341 p. 47 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030659165
    Series Statement: Children’s Well-Being: Indicators and Research, 23
    DDC: 660.6
    Language: English
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  • 94
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant genetics. ; Plant biotechnology. ; Agriculture. ; Plant Genetics. ; Plant Biotechnology. ; Agriculture.
    Description / Table of Contents: Chapter 1. World Trade and Economic Importance of Apple -- Chapter 2. Botany, Taxonomy, and Origins of the Apple -- Chapter 3. Apple Genetic Resources: Diversity and Conservation -- Chapter 4. Ploidy, Genome Size, and Cytogenetics of Apple -- Chapter 5. Genetics and Breeding of Apple Scions -- Chapter 6. Genetics, Breeding, and Genomics of Apple Rootstocks -- Chapter 7. Genetic and Physical Mapping of the Apple Genome -- Chapter 8. The Apple Genome and Epigenome -- Chapter 9. Regulatory Sequences in Apple -- Chapter 10. Genome Editing in Apple -- Chapter 11. Flowering and Juvenility in Apple -- Chapter 12. Genetics and Genomics of Cold Hardiness and Dormancy -- Chapter 13. Genetics and Genomics of Fruit Color Development in Apple -- Chapter 14. Genomics of Fruit Acidity and Sugar Content in Apple -- Chapter 15. Metabolomic Approaches for Apple Fruit Quality Improvement -- 16. The Apple Microbiome: Structure, Function, and Manipulation for Improved Plant Health -- Chapter 17. Origin of the Domesticated Apple -- Chapter 18. Future Prospects of ‘Omics’ and of Other Technologies for Genetic Improvement of Apple.
    Abstract: This book covers information on the economics; botany, taxonomy, and origin; germplasm resources; cytogenetics and nuclear DNA; genetic improvement efforts of scion cultivars; genetic and genomic improvement efforts of rootstocks; genetic and physical mapping; genomic resources; genome and epigenome; regulatory sequences; utility of whole-genome sequencing and gene editing in trait dissection; flowering and juvenility; cold hardiness and dormancy; fruit color development; fruit acidity and sugar content; metabolomics; biology and genomics of the microbiome; apple domestication; as well as other ‘omics’ opportunities and challenges for genetic improvement of the apple. The cultivated apple (Malus x domestica Borkh.) is one of the most important tree fruit crops of temperate regions of the world. It is widely cultivated and grown in North America, Europe, and Asia. The apple fruit is a highly desirable fruit due to its flavor, sugar and acid content, metabolites, aroma, as well as its overall texture and palatability. Furthermore, it is a rich source of important nutrients, including antioxidants, vitamins, and dietary fiber.
    Type of Medium: Online Resource
    Pages: XXV, 412 p. 76 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030746827
    Series Statement: Compendium of Plant Genomes,
    DDC: 581.35
    Language: English
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  • 95
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant genetics. ; Plant biotechnology. ; Agriculture. ; Plant Genetics. ; Plant Biotechnology. ; Agriculture.
    Description / Table of Contents: Economic and Academic Importance -- Botanical descriptions -- Oil composition and nutrition -- Genetic Resources -- Classical Genetics -- Germplasm creation and breeding -- Genetic Inkage maps, mapping of genes and QTLs -- Cytological details of genome -- Structural & functional genomic resources developed -- Requirement of whole-genome sequencing -- Background history of the national and international genome initiatives, public and private partners involved -- Strategies & tools for sequencing -- Enumeration of sequences -- Assembly -- Repetitive sequences -- Gene annotation -- Genome duplication -- Synteny with allied & model genomes -- Comparison of gene families -- Impact on germplasm characterization & gene discovery -- Impact on plant breeding -- Future Prospects.
    Abstract: This book is the first comprehensive compilation of deliberations on whole genome sequencing of sesame including genome assembly, annotation, structure and synteny analysis, and sequencing of its chloroplast genome and also its wild species. It presents narratives on classical genetics and breeding, tissue culture and genetic transformation, molecular mapping and breeding. Other chapters describe the beneficial components in sesame protein and oil, botanical depictions and cytological features. Prospects of designed breeding in the post-genomics era including gene discovery have also been enumerated. Altogether, the book contains 19 chapters authored by globally reputed experts on the relevant field in this crop. This book is useful to the students, teachers, and scientists in the academia and relevant private companies interested in classical and molecular genetics, biotechnology, breeding, biochemistry, traditional and molecular breeding, and structural and evolutionary genomics. The work is also useful to seed and oil industries.
    Type of Medium: Online Resource
    Pages: XIX, 296 p. 124 illus., 96 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783319980980
    Series Statement: Compendium of Plant Genomes,
    DDC: 581.35
    Language: English
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  • 96
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Medicine Research. ; Biology Research. ; Biology Technique. ; Biotechnology. ; Biomedical Research. ; Experimental Organisms.
    Description / Table of Contents: Morphology Study – Optical Microscopy Imaging, Electron Microscopy Imaging, Confocal Microscopy Imaging, Live Cell Imaging -- Methods to Detect Autophagic Flux -- Biomarkers in Autophagy -- Drugs and Molecular Biology Technology in Autophagy Study -- Animal Models in Autophagy Study.
    Abstract: This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 3 focuses on the technical aspects of autophagy research. It is comprised of two parts. The first part discusses the basic process of autophagy, including its overall classification and individual stages in the life cycle of autophagosomes. The second part discusses the tools, strategies, and model systems in current autophagy research, including cell and animal models, detection and manipulation methods, as well as screening, genomic, proteomic and bioinformatic approaches. The book is written and edited by a team of active scientists. It is intended as a practical reference resource for interested researchers to get started on autophagy studies.
    Type of Medium: Online Resource
    Pages: XIV, 453 p. 85 illus., 79 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811628306
    Series Statement: Advances in Experimental Medicine and Biology, 1208
    DDC: 660.6
    Language: English
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  • 97
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Psychobiology. ; Human behavior. ; Sex. ; Behavioral Neuroscience. ; Gender Studies.
    Description / Table of Contents: 1-Measuring Sex Differences and Similarities -- 2-Prenatal Steroid Hormones and Sex Differences in Juvenile Rhesus Macaque Behavior -- 3-Biological Approaches to Studying Gender Development -- 4-Social Influences on Gender Development: Theory and Context -- 5-Contemporary Cognitive Approaches to Gender Development: New Schemas, New Directions, and New Conceptualizations of Gender -- 6-Origins and Consequences of Childhood Gender Segregation: Towards an Integrative Developmental Systems Model -- 7-Gender, Toys, and Play: How Gendered Early Experiences Shape Later Development -- 8-Family Gender Socialization in Childhood and Adolescence -- 9-Gender Stereotypes and Education -- 10-Gender-Based Discrimination in Childhood and Adolescence -- 11-Gender and Sexuality in Disorders/Differences of Sex Development -- 12-Sexuality Development in Childhood -- 13-Sexual Pleasure in Adolescence: A Developmental Sexual Embodiment Perspective -- 14-Pornography Use in Adolescence and Young Adulthood -- 15-A Review of Theoretical Models and Lifespan Approaches to the Study of Sexual Offending -- 16-Learned but Not Chosen: A Reward Competition Feedback Model for the Origins of Sexual Preferences and Orientations -- 17-Carving the Biodevelopment of Same-Sex Sexual Orientation at Its Joints -- 18-Mental Health Among LGBT Youth -- 19-Asexuality: When Sexual Attraction is Lacking -- 20-Erotic Target Identity Inversions -- 21-Consensual Non-monogamy from a Developmental Perspective.
    Abstract: This book showcases a wealth of knowledge and insight on gender and sexuality development. With contributions from leading researchers, it covers a comprehensive set of topics at the forefront of the field and strikes a balance between traditional and emerging areas of study. Given that gender and sexuality are shaped by myriad influences, this book is modelled on an interdisciplinary perspective and delves into biological, comparative, psychological, cognitive, social, cultural, and clinical approaches. In so doing, this collection conveys the rich tapestry of gender and sexuality science and will hold value for many. For those already in the field, this book provides an excellent resource for brushing up on the latest and for inspiring the next phases of scientific investigation. Those who are newer to the field, including undergraduate and graduate students, stand to gain tremendously from not only the thoughtful and informative content, but also from the interdisciplinary approach modelled throughout the book. Beyond academia, this book is a valuable resource for clinicians and policy makers who deal with child and adolescent issues.
    Type of Medium: Online Resource
    Pages: XXIII, 636 p. 21 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030842734
    Series Statement: Focus on Sexuality Research,
    DDC: 612.8
    Language: English
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  • 98
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Agriculture. ; Biotechnology. ; Plant biotechnology. ; Food science. ; Plant genetics. ; Agriculture. ; Biotechnology. ; Plant Biotechnology. ; Food Science. ; Plant Genetics.
    Description / Table of Contents: Chapter 1. Plant transformation techniques -- Chapter 2. Strategies to enhance the expression of the transgene in plants -- Chapter 3. Cisgenics and crop improvement -- Chapter 4. Transgenics and crop improvement -- Chapter 5. Molecular pharming -- Chapter 6. Future prospects of GM plants.
    Abstract: This book presents up-to-date information on various vector-less/direct (physical, chemical) and vector-mediated/indirect (Agrobacterium-mediated) plant transformation techniques. It summarizes various strategies that facilitate a gene from lower organism to be expressed in higher plants and also in silico designing of synthetic gene for higher expression. It also highlights the importance of strong promoters to drive the expression of transgene(s). This book encompasses the advantages and drawbacks of cisgenesis and transgenesis, their implications towards sustainable crop improvement, and their future prospects. The importance, limitations, challenges, recent developments, and future prospects of molecular pharming is also discussed. The book concludes with a chapter that summarizes the major contribution of GM-crops towards global food security and economy, advances in genome editing for crop improvement, challenges and risk associated with the release of GM-crops, and the future of GM technology. This book is meant for students and researchers in the field of life sciences, food science, and agriculture. .
    Type of Medium: Online Resource
    Pages: XXIII, 424 p. 92 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811921193
    DDC: 630
    Language: English
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  • 99
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Food science. ; Fungi. ; Mycology. ; Microbiology. ; Pharmacology. ; Ecology . ; Food Science. ; Fungi. ; Pharmacology. ; Ecology.
    Description / Table of Contents: Ch-01 : Introduction -- Ch-2. Ecology of Fungal Food Spoilage -- Ch 3. Naming and Classifying Fungi -- Ch-4 Methods for Enumeration, Isolation and Identification -- Ch-5 Primary Keys and Miscellaneous Fungi -- Ch 6- Zygomycetes -- Ch 7 Penicillium and Talaromyces -- Ch 8 Aspergillus and Related Teleomorphs -- Ch 9 Xerophiles -- Ch 10 - Yeasts -- Ch 11: Fresh and Perishable Foods -- Ch 12- Spoilage of Stored, Processed and Preserved Foods -- Ch 13: Mycotoxins.
    Abstract: The first three editions of Fungi and Food Spoilage established, then consolidated, a reputation as the leading book on foodborne fungi. It details media and methods for isolation and identification, descriptions of species, and information on their physiology, ecology and mycotoxin formation. It is an invaluable reference for food microbiologists investigating fungal food spoilage problems, both in field crops and processed foods, and the likelihood of mycotoxin production in either. The Fourth Edition incorporates major differences from the Third: multiple changes in nomenclature due to changes in the International Code of Nomenclature for algae, fungi and plants; many taxonomic changes due to improvements in, and more widespread application of, molecular methods in taxonomy; the introduction of colour colony photographs where appropriate; and a new chapter on mycotoxins. The introductory chapters of the book deal with the ecology of food spoilage, and provide an overview of how food processing, packaging and storage parameters influence fungal growth. A subsequent chapter overviews the fundamentals of naming and classifying fungi. Morphological methods and media suitable for low cost and effective isolation, enumeration and identification of foodborne fungi are provided, together with many more specialised media and techniques. The major part of the book provides keys, descriptions and illustrations of all yeasts and filamentous fungi commonly encountered in foods. Other known characteristics of the species, including physiology and ecology are included. Chapters on the types and species of fungi likely to be found in fresh, harvested and variously processed foods are followed by a new chapter on mycotoxins, both major and minor, their sources, both fungal and food, and their implications for human health. The broad and practical nature of the coverage will appeal to microbiologists, mycologists and biotechnologists in the food industry, as well scientists in academic, research and public health institutions. Drs Pitt and Hocking worked for CSIRO Food for more than 100 years combined. Both are now retired from CSIRO: Dr Pitt continues to work part time with Microbial Screening Technologies, a biodiscovery company.
    Type of Medium: Online Resource
    Pages: XXI, 645 p. 186 illus., 110 illus. in color. , online resource.
    Edition: 4th ed. 2022.
    ISBN: 9783030856403
    DDC: 641.3
    Language: English
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  • 100
    Keywords: Agriculture. ; Biodiversity. ; Plant propagation. ; Food science. ; Agricultural genome mapping. ; Agriculture. ; Biodiversity. ; Plant Domestication. ; Food Science. ; Agricultural Genetics.
    Description / Table of Contents: Chapter. 1. Introduction -- Chapter. 2. Domestication and Evolution of Ancient Wheats -- Chapter. 3. Origin, Taxonomy and Distribution of Ancient Wheats in Turkey -- Chapter. 4. Genetic Diversity in Ancient Wheats -- Chapter. 5. Conservation Strategies -- Chapter. 6. Chemical Composition of Einkorn (Triticum monococcum ssp. monococcum), Emmer (Triticum dicoccum), and Spelt (Triticum spelta) -- Chapter. 7. Nutritional and Technological Aspects of Ancient Wheat -- Chapter. 8. From hologenomes to biofertilizers in wheat production -- Chapter. 9. Wild relatives and their contributions to wheat breeding -- Chapter. 10. Socio-economic evaluation of einkorn wheat production.
    Abstract: Wheat (Triticum L.), an annual herbaceous plant in Poacae (Gramineae) family, settles in the Triticeae (Hordeae) subfamily. The grasses (Poaceae Barnhart) are the fifth largest (monocotyledonous flowering) plant family and of great importance for human civilization and life. Cereal crops such as maize, wheat, rice, barley, and millet are the domesticated ones in the family. It is still the most vital economical plant family in modern times, providing food, forage, building materials (bamboo, thatch), and fuel (ethanol). Wheat has many accessions in national and international gene banks. The estimated number of wheats by FAO in 2010 is 856,000, and, followed by rice (774,000), and barley (467,000). However, the recent consumer's (misdirected) focus on gluten content and nutritional value urges scientists to reexamine their knowledge about wheat (i.e., origin, evolution, and general and special quality characteristics), as well as their wild relatives and landraces for newer possible genetic resources. Cultured or non-cultured ancestral wheats: einkorn, emmer, wild emmer, spelt, macha, and vavilovii are still limitedly grown on the higher areas in Turkey, Italy, Germany, Morocco, Israel, and Balkan countries. They are exploited mostly for their desired agronomic, and specific quality. In some cultures, wheat species are believed to be therapeutic, with bioactive compounds that reduce and inhibit stubborn illnesses such as diabetes, cancer, Alzheimer, and cardiovascular diseases. In this book, we summarize the importance of ancestral wheat species, and provide a prospect for their future with special considerations in terms of species conservation and improvement. .
    Type of Medium: Online Resource
    Pages: XVII, 260 p. 76 illus., 67 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031072857
    DDC: 630
    Language: English
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