Abstract
ONE of the most significant advances in cellular radiobiology was the development by Puck and Marcus1 of a technique by means of which the survival from irradiation of animal cells in culture was placed on a quantitative basis. Survival has usually been expressed arbitrarily as the ability of an irradiated cell to produce, over a 10–20-day period, a macroscopic clone of descendants comprising at least 50 ‘normal’ (that is, non-giant) cells.
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Puck, T. T., and Marcus, P. I., J. Exp. Med., 103, 653 (1956).
Greenblatt, C. L., Intern. J. Rad. Biol., 4, 185 (1961).
Barendsen, G. W., in The Initial Effects of Ionizing Radiation on Cells, edit. by Harris, R. J. C., 183 (New York: Academic Press, 1961).
Taylor, J. H., J. Cell. Comp. Physiol., 62, Suppl. 1, 149, 150 (1963).
Tolmach, L. J., J. Cell. Comp. Physiol., 62, Suppl. 1, 150 (1963).
Archambeau, J. D., Drew, R. M., and Robertson, J. S., The Biological Effects of Neutron and Proton Irradiations, 1, 343 (Vienna: Intern. Atomic Energy Agency, 1964).
Whitmore, G. F., and Till, J. E., Ann. Rev. Nucl. Sci., 14, 347 (1964).
Elkind, M. M., and Sinclair, W. K., in Current Topics in Radiation Research, edit. by Ebert, M., and Howard, A., 1, 165 (Amsterdam: New Holland Publishing Co., 1965).
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ROBINSON, D. ‘Cell Killing’ in Radiobiology. Nature 208, 500 (1965). https://doi.org/10.1038/208500a0
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DOI: https://doi.org/10.1038/208500a0
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