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Another brick in the wall

Nature Structural Biology volume 7, pages 94–96 (2000)Cite this article

Abstract

The X-ray crystal structure of Mycobacterium tuberculosis antigen 85C elucidates the structural basis of fibronectin binding and catalysis of mycolic acid transfer by this potential drug target.

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Figure 1: Trehalose dimycolate (TDM) or cord factor is comprised of trehalose (2 D-glucose residues joined by their anomeric carbons) esterifed through their 6- and 6′- hydroxyl groups to two mycolic acid residues.
Figure 2: Schematic representation of the mycobacterial cell wall.
Figure 3: Ribbon diagram of ag85C with other members of the α/β hydrolase fold superfamily of enzymes.
Figure 4

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  1. the Department of Chemistry, State University of New York at Stony Brook, Stony Brook, 11794-3400, New York, USA

    Peter J. Tonge

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Tonge, P. Another brick in the wall. Nat Struct Mol Biol 7, 94–96 (2000). https://doi.org/10.1038/72458

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