Summary
Streptomyces olivaceus TÜ 2718 produces the siderophore desferrioxamine E. Production depends on l-lysine and iron concentrations in the medium. With optimized conditions the yield of desferrioxamine E could be increased to 12g/1 in feeding fermentations. Supplementation of the basic production medium with natural and synthetic precursors of desferrioxamine E led to the production of twelve new analogues of desferrioxamine E.
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Meiwes, J., Fiedler, HP., Zähner, H. et al. Production of desferrioxamine E and new analogues by directed fermentation and feeding fermentation. Appl Microbiol Biotechnol 32, 505–510 (1990). https://doi.org/10.1007/BF00173718
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DOI: https://doi.org/10.1007/BF00173718