Summary
Studies reporting a suspected association between breast cancer and rauwolfia derivatives were first published in 1974 and more recent studies have produced conflicting results. A further study is described in which groups of investigators from Aberdeen, Dundee and London attempted to ascertain the previous exposure to rauwolfia derivatives of female patients discharged from hospital with a confirmed diagnosis of breast cancer. Their exposure as recorded in the hospital and general practitioners' records was compared with that in two control groups, matched by general practitioner, age, year of admission to hospital and marital state, the first comprising patients with a cancer other than breast cancer and the second, patients with a non-malignant disorder. For patients with breast cancer compared with those with a non-malignant disorder the overall estimate of the relative risk of breast cancer in patients exposed to rauwolfia derivatives is 0.94 (95 patients exposed). The occurrence of hypertension and use of hypotensive agents and prolactin stimulators was also noted. Possible sources of bias were examined and none appeared to be significant. The problems created by the multicentre approach are also discussed.
Similar content being viewed by others
References
Boston Collaborative Drug Surveillance Program: Reserpine and breast cancer. Lancet1974 II, 669–671
Armstrong, B., Stevens, N., Doll, R.: Retrospective study of the association between use of rauwolfia derivates and breast cancer in English women. Lancet1974 II, 672–675
Heinonen, O.P., Shapiro, S., Tuominen, L., Turunen, M.: Reserpine use in relation to breast cancer. Lancet1974 II, 675–677
O'Fallon, W.M., Labarthe, D.R., Kurkland, L.T.: Rauwolfia derivates and breast cancer. Lancet1975 II, 292–296
Laska, E.M., Siegel, C., Meisner, M., Fischer, S.: Matchedpairs study of reserpine use and breast cancer. Lancet1975 II, 296–300
Mack, T.M., Henderson, B.E., Gerkins, V.R., Arthur, M., Babtischa, J., Pire, M.C.: Reserpine and breast cancer in a retirement community. New Engl.J.Med.292, 1366–1371 (1975)
Armstrong, B., Skegg, D., White, G., Doll, R.: Rauwolfia derivates and breast cancer in hypertensive women. Lancet1976 II, 8
Aromaa, A., Hakama, M., Hakulinen, M., Saxen, E., Teppo, L., Idanpaan-Heikkila, J.: Breast cancer and use of antihypertensives in hypertensive patients. Int. J. Cancer in press
Author information
Authors and Affiliations
Consortia
Additional information
Members of the Group: L.J. Christopher, J. Crooks, Dept. of Pharmacology and Therapeutics, University of Dundee, Scotland, J.F. Davidson, Z.G. Erskine, S.C. Gallon, D.C. Moir, R.D. Weir, Department of Community Medicine, University of Aberdeen, Scotland.
Bristol Royal Infirmary, England
Rights and permissions
About this article
Cite this article
Christopher, L.J., Crooks, J., Davidson, J.F. et al. A multicentre study of rauwolfia derivates and breast cancer. Eur J Clin Pharmacol 11, 409–417 (1977). https://doi.org/10.1007/BF00562930
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00562930