Abstract
An experimental Keratitis study of Aspergillus fumigatus was performed in 130 rabbits divided into 12 groups of ten animals each. Three antifungal drugs (myconazole, amphotericin B and pimaricin) were tested using two procedures (topical drops and subconjunctival injections) and two different concentrations (500 and 10 000 times the MIC). In each case, the drugs were applied every 3 h starting 14 h after inoculation.
Miconazole was useful at 10 mg/ ml concentration by topical drops and subconjunctival injections, but was less useful at 5 mg/ ml.
Amphotericin B was useful at 5 mg/ ml concentration by topical drops and less useful at 2 mg/ ml.
No differences were found between the two concentrations by subconjunctival administration.
Pimaricin was useful by topical drops at 50 mg/ ml concentration and less useful at 10 mg/ ml as well as by subconjunctival injections.
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References
Abraham, J. E., 1975. Treatment with Miconazole eye cream. Janssen Phamaceutica. Depart. of Coumentation B-2340 Beerse (Belgium).
Allen, H. S., 1972. Amphotericin B and exogenous mycotic endophthalmitis after cataract extraction. Arch. Ophthalmol. 88: 640–644.
Anderson, B. & Chick, E. W., 1963. Mycokeratitis: Treatment of fungal corneal ulcers with Amphotericin B and mechanical debridement. South. Med. J. 56: 270–274.
Arrechea, A. & Zapater, R. C., 1973. Tratamiento químico de la queratomicosis. Arch. Oftalmol. 48: 229–233.
Arrechea, A. & Zapater, R. C., 1977. Tratamiento con miconazol de una-queratitis por Fusarium oxysporum. Arch. Soc. Oftalmol. 52: 141–143.
Ellison, A. C., Newmark E. & Kaufman, H. E., 1969. Chemotherapy of experimental Keratomycosis. Am. J. Ophthalmol. 68: 812–819.
Ellison, A. C. & Newmark, E., 1973. Effects of subconjunctival pimaricin in experimental Keratomycosis. Am. J. Ophthalmol. 75: 790–792.
Foster, R. K. & Rebell, G., 1975. The diagnosis and management of Keratomycoses. II. Medical and surgical management. Arch. Ophthalmol. 93: 1134–1136.
Foster, C. S. & Stefanyszyn, M., 1979. Intraocular penetration of miconazole in rabbits. Arch. Ophthalmol. 97: 1703–1706.
Jones, D. B., Forster, R. K. & Rebell, G., 1972. Fusarium solanii keratitis treated with natamycin. Arch. Ophthalmol. 88: 147–152.
Jones, B. R., Richards, A. B. & Clayton, Y. M., 1974. Clotrimazole in the treatment of ocular infection by Aspergillus fumigatus. Postgraduate Med. J.: 39–45.
Mangiaracine, A. B. & Liebman, S. D., 1957. Fungus Keratitis (Aspergillus fumigatus). Arch. Ophthalmol. 58: 695–698.
Manning, L. K. & Robertson, L., 1959. A case of Aspergillosis treated with nystain. Br. Med. J. 16: 345–346.
Montana, J. A. & Sery, T. W., 1955. Corneal infections after cortison therapy. Br. J. Ophthalmol. 39: 462–465.
Newmark, E., Ellison, A. C. & Kauffman, H. E., 1970. Pimaricin therapy of Cephalosporin and Fusarium Keratitis. Am. J. Ophthalmol. 69: 458–466.
Newmark, E., Ellison, A. C. & Kauffman, H. E., 1971. Combined pimaricin and dexamethasone therapy of Keratomycosis. Am. J. Ophthalmol. 71: 718–722.
Palma, L., Ramirez Fasoli, G. & Zapater, R. C., 1975. Tratamiento con miconazol de dos queratomicosis originadas por Aspergillus flavus. Arch. Oftalmol. 50: 145–148.
Palma, L., Ramirez Fasoli, G. & Zapater, R. C., 1977. Tratamiento con miconazol de dos Queratomicosis originadas por Aspergillus flavus. Arch. Oftalmol. 52: 145–148.
Stern, G. A., Okumoto, M. & Smolin, G., 1979. Combined amphotericin B and rifampin treatment of experimental Candida albicans Keratitis. Arch. Ophthalmol. 97: 721–722.
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de Lomas, J.G., Fons, M.A., Nogueira, J.M. et al. Chemotherapy of Aspergillus fumigatus keratitis: An experimental study. Mycopathologia 89, 135–138 (1985). https://doi.org/10.1007/BF00447021
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DOI: https://doi.org/10.1007/BF00447021