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New resorbable polymeric systems with antithrombogenic activity

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Abstract

The synthesis and application as resorbable coatings of vascular grafts of a new polyacrylic derivative of Triflusal (2-acetyloxy-4-trifluoromethyl)benzoic acid, a commercial drug with antithrombogenic properties, are described. The high-molecular-weight polyacrylic system is rather stable in physiological conditions and provides a chemical support for the slow release of the pharmacologically active compound, Triflusal, or its main metabolite (2-hydroxy-4-trifluoromethyl)benzoic acid (HTB). Experiments of deposition and retention of platelets in static basal conditions using plasma-rich medium from blood of sheep, seem to indicate that the polymeric coating of the polyacrylic derivative of Triflusal improves the antiaggregating character for platelets of the surface of small-diameter vascular grafts without the application of other antithrombogenic drugs.

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References

  1. D. Basmadjian, M. V. Sefton and S. A. Baldwin, Biomaterials 18 (1997) 1511.

    Google Scholar 

  2. E. W. Davie, K. Fujikawa and W. Kisiel, Biochemistry 30 (1991) 10 363.

    Google Scholar 

  3. K. Ishihara, Trends Polym. Sci. 5 (1997) 401.

    Google Scholar 

  4. Z. Zdanowski, B. Koul, E. Hallberg and C. Schalen, J. Biomater. Sci. Polym. Ed. 8 (1997) 825.

    Google Scholar 

  5. J. A. Chinn, J. A. Sauter, R. E. Phillips, W. J. Kao, J. M. Anderson, S. R. Hanson and T. R. Ashton, J. Biomed. Mater. Res. 39 (1998) 130.

    Article  Google Scholar 

  6. H. Noguchi, H. Iwata and Y. Ikada, J. Biomed. Mater. Res. 39 (1998) 621.

    Google Scholar 

  7. Y. Ito, L. S. Lin, R. Matsno and Y. Imanishi, J. Biomed. Mater. Res. 26 (1992) 1065.

    Google Scholar 

  8. T. Matsuda, H. Iwata, H. Noda, T. Toyosaki, H. Talcano and T. Akutsu, Trans. Amer. Soc. Artif. Intern. Organs 31 (1985) 244.

    Google Scholar 

  9. T. Matsuda and S. Ito, Biomaterials 15 (1994) 417.

    Article  PubMed  Google Scholar 

  10. S. W. Kim and J. Feijen, CRC Crit. Rev. Biocompat. 1 (CRC Press, Boca Raton FL, 1985).

    Google Scholar 

  11. J. H. Lee, H. B. Lee and J. D. Andrade, Prog. Polym. Sci. 20 (1995) 1043.

    Article  Google Scholar 

  12. J. H. Chesebro, V. Fuster and L. R. Flueback, N. Engl. J. Med. 310 (1984) 209.

    Google Scholar 

  13. S. M. Rajah, M. C. P. Salter and D. R. Donaldson, J. Thorac. Cardiovasc. Surg. 90 (1985) 373.

    Google Scholar 

  14. B. B. Weksler, S. B. Pett and D. Alonso, N. Engl. J. Med. 308 (1983) 800.

    Google Scholar 

  15. J. San RomaÂn, M. C. Escudero, A. Gallardo, R. Santa Cruz, E. Jorge, J. De Haro, L. Alvarez, J. MillaÂn, J. BujaÂn, J. M. BelloÂn and J. C. Castilloolivares, Biomaterials 15 (1994) 759.

    Article  Google Scholar 

  16. J. San RomaÂn, J. BujaÂn, J. M. BelloÂn, A. Gallardo, M. C. Escudero, E. Jorge, J. De Haro, L. Alvarez and J. C. Castillo-Olivares, J. Biomed. Mater. Res. 32 (1996) 19.

    Article  Google Scholar 

  17. P. Guiteras, J. Altimiras, A. Aris, J. M. Auge, T. Bassons, J. Bonal, J. M. Casalps, C. Castellarnau, C. Crexells, M. Masotti, A. Oriol, J. M. Padro and M. Rutllant, Eur. Heart J. 10 (1989) 159.

    Google Scholar 

  18. J. P. De La Cruz, M. A. Villalobos, P. J. GarciÂa, J. M. Smith-Agreda and F. SaÂnchez De La Cuesta, Eur. J. Clin. Pharmacol. 47 (1995) 497.

    Google Scholar 

  19. R. J. Fort and T. M. Polyzoidis, Eur. Polym. J. 12 (1976) 685.

    Article  Google Scholar 

  20. J. Ramis, J. Torrent, R. Mis, L. Conte, M. J. Barbanoj, J. Jane and J. Forn, Int. J. Clin. Pharm. Ther. Tox. 28 (1990) 344.

    Google Scholar 

  21. Y. Imanishi, Y. Ito, L. S. Lin and M. Kajihara, J. Macromol. Sci. Chem. A 25 (1998) 555.

    Google Scholar 

  22. J. Mathew, S. Q. Lin and M. Kodama, Biomaterials 14 (1993) 57.

    Article  Google Scholar 

  23. A. Kishida, H. I. Iwata, Y. Tamada and Y. Ikada, Biomaterials 12 (1991) 786.

    Article  Google Scholar 

  24. C. Nojini, T. Okano, H. A. Jacobs, K. D. Park, S. F. Mohamad, D. B. Olsen and S. W. Kim, J. Biomed. Mater. Res. 24 (1990) 1151.

    PubMed  Google Scholar 

  25. T. Yoneyama, K. I Shihara, N. Nakabayashi, M. Ito and Y. Mishima, Appl. Biomater. 43 (1998) 15.

    Article  Google Scholar 

  26. E. Kulik and Y. Ikada, Appl. Biomater. 30 (1996) 295.

    Article  Google Scholar 

  27. P. A. Liso, M. Rebuelta, J. San RomanÂ, A. Gallardo and A. M. Villar, J. Controlled Release 33 (1995) 429.

    Article  Google Scholar 

  28. E. W. Merril, P. W. Pekala and N. A. Mahmud, in “Hydrogels in medicine and pharmacy” Vol. 3, edited by N. A. Peppas (CRC Press, Boca Raton, 1987) p. 1.

    Google Scholar 

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Authors and Affiliations

  1. Instituto de Ciencia y Tecnologı´a de Polı´meros, CSIC, c/Juan de la Cierva 3, 28006, Madrid, Spain

    G. Rodri´guez, A. Gallardo & J. San Roma´n

  2. Department of Pharmacology, Faculty of Pharmacy, UCM, Madrid, Spain

    M. Rebuelta & P. Bermejo

  3. Department of Surgery, Faculty of Medicine, UAH, Madrid, Spain

    J. Buja´n, J. M. Bello´n & N. G. Honduvilla

  4. Experimental Surgery, Clinica Puerta de Hierro, Madrid, Spain

    C. Escudero

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  1. G. Rodri´guez
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  2. A. Gallardo
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  3. J. San Roma´n
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  4. M. Rebuelta
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  7. J. M. Bello´n
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Rodri´guez, G., Gallardo, A., Roma´n, J.S. et al. New resorbable polymeric systems with antithrombogenic activity. Journal of Materials Science: Materials in Medicine 10, 873–878 (1999). https://doi.org/10.1023/A:1008985302826

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  • DOI: https://doi.org/10.1023/A:1008985302826

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