Skip to main content
SpringerLink
Log in

The effects of beta-endorphin on arginine-8-vasopressin and oxytocin levels in rat brain areas

  • Research Articles
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Measurements were made of the effects of intracerebroventricular treatment with beta-endorphin (BE; 100 ng) on the arginine-8-vasopressin (AVP) and oxytocin contents of rat hypothalamic and limbic brain areas (hippocampus, amygdala and septum). The hormone concentrations were determined by radioimmunoassay. The administration of BE resulted in a significant reduction of the AVP level in the amygdala in a naloxone-reversible manner. Naloxone (Nal) administered subcutaneously significantly increased the AVP content in the septum. The results revealed that BE and Nal had regionally specific effects on the activity of the vasopressinergic system but not on that of the oxytocinergic system in the brain.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ten Haaf, J. A., Van Wimersma Greidanus, Tj. B., Maigret, C., and De Wied, D., Neuroendocrinology44 (1986) 102.

    Article  PubMed  Google Scholar 

  2. Van Wimersma Greidanus, Tj. B., and Ten Haaf, J. A., in: Oxytocin: Clinical and Laboratory Studies, p. 145. Eds. J. A. Amico and A. G. Robinson. Elsevier, Amsterdam 1985.

    Google Scholar 

  3. Pittman, J. Q., Hatton, J. D., and Bloom, F. E., Proc. natl. Acad. Sci. USA77 (1980) 5527.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Wuarin, J. P., Dubois-Dauphin, M., Raggenbass, M., and Dreifuss, J. J., Brain Res.445 (1988) 289.

    Article  CAS  PubMed  Google Scholar 

  5. Khachaturian, H., Lewis, M. E., Kang Tsou, and Watson, S. J., in: GABA and Neuropeptides in the CNS. Handbook of Chemical Neuroanatomy, vol. 4, p. 231. Eds A. Björklund and T. Hökfelt. Elsevier, Amsterdam 1985.

    Google Scholar 

  6. Petrus, P., Merchenthaler, I., and Maderdrut, J. L., in: GABA and Neuropeptides in the CNS. Handbook of Chemical Neuroanatomy, vol. 4, p. 273. Eds A. Björklund and T. Hökfelt. Elsevier, Amsterdam 1985.

    Google Scholar 

  7. Clarke, G., Wood, P., Merrick, L., and Lincoln, D. W., Nature282 (1979) 746.

    Article  CAS  PubMed  Google Scholar 

  8. Bicknell, R. J., and Leng, G., Nature298 (1982) 161.

    Article  CAS  PubMed  Google Scholar 

  9. Kovács, G. L., Laczi, F., Vecsernyés, M., Hódi, K., Telegdy, G., and László, F. A., Exp. Brain Res.65 (1987) 307.

    Article  PubMed  Google Scholar 

  10. Kovács, G. L., and De Wied, D., in: Endogenous Peptides and Memory Processes, p. 231. Eds J. Martinez Jr, H. Rigter, J. Jenssen, R. B. Messing and J. L. McGauh. Academic Press, New York 1981.

    Chapter  Google Scholar 

  11. Gispen, W. H., Schotman, P., and De Kloet, E. R., Neuroendocrinology9 (1972) 285.

    Article  CAS  PubMed  Google Scholar 

  12. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem.193 (1951) 265.

    Article  CAS  PubMed  Google Scholar 

  13. Dogterom, J., Snijdevint, F. G. M., and Buijs, R. M., Neurosci. Lett.9 (1978) 341.

    Article  CAS  PubMed  Google Scholar 

  14. Laczi, F., Vesernyés, M., Kovács, G. L., Szabó, G., Janáky, T., Telegdy, G., and László, F. A., Brain Res.403 (1987) 155.

    Article  CAS  PubMed  Google Scholar 

  15. Van Leeuwen, F., and Caffe, R., Cell Tiss. Res.228 (1983) 525.

    Article  Google Scholar 

  16. Badawy, A. A., Evans, M., Punjani, N. F., and Morgan, C. J., Life Sci.33, suppl. (1983) 739.

    Article  CAS  PubMed  Google Scholar 

  17. Dingledine, R., Iversen, L. L., and Breuker, E., Eur. J. Pharm.47 (1978) 19.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Endocrine Unit and Research Laboratory, First Department of Medicine, Albert Szent-Györgyi Medical University, POB 469, H-6701, Szeged, Hungary

    M. Vecsernyés, F. Laczi & T. Janáky

  2. Central Laboratory, Markusovszky Teaching Hospital, Szombathely, Hungary

    G. L. Kovács

  3. Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary

    G. Szabó & G. Telegdy

  4. Department of Comparative Physiology, Attila József University of Sciences, Szeged, Hungary

    F. A. László

Authors
  1. M. Vecsernyés
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Laczi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. L. Kovács
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Szabó
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. Janáky
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. Telegdy
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. F. A. László
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vecsernyés, M., Laczi, F., Kovács, G.L. et al. The effects of beta-endorphin on arginine-8-vasopressin and oxytocin levels in rat brain areas. Experientia 45, 472–474 (1989). https://doi.org/10.1007/BF01952034

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01952034

Key words

Search

Navigation