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Effect of piperazine on central and peripheral cholinergic synapses of the frog

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Summary

The anthelmintic agent piperazine did not antagonize carbachol-induced depolarizations of the frog sartorius muscle but depressed root potentials and acetylcholine release from the frog spinal cord. We suggest that piperazine has a presynaptic site of action at central cholinergic nerve-terminals.

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Author notes

  1. A. Nistri

    Present address: Department of Research in Anaesthesia, McGill University, 3655 Drummond Street, H3G 1Y6, Montreal, Canada

Authors and Affiliations

  1. Department of Pharmacology, St. Bartholomew's Hospital Medical College, University of London, EC1M 6BQ, London, England

    A. Nistri & M. S. Arenson

Authors
  1. A. Nistri
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  2. M. S. Arenson
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Nistri, A., Arenson, M.S. Effect of piperazine on central and peripheral cholinergic synapses of the frog. Experientia 34, 1046–1047 (1978). https://doi.org/10.1007/BF01915338

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