Quantum physics is intrinsically probabilistic, where the Born rule yields the probabilities associated with a state that deterministically evolves. The entropy of a quantum state quantifies the amount of randomness (or information loss) of such a state. The degrees of freedom of a quantum state are position and spin. We focus on the spin degree of freedom and elucidate the spin-entropy. Then, we present some of its properties and show how entanglement increases spin-entropy. A dynamic model for the time evolution of spin-entropy concludes the paper. Full article

This study investigates the in vitro activity of Nα-aroyl-N-aryl-phenylalanine amides (AAPs), previously identified as antimycobacterial RNA polymerase (RNAP) inhibitors, against a panel of 25 non-tuberculous mycobacteria (NTM). The compounds, including the hit compound MMV688845, were selected based on their structural diversity and previously described activity against mycobacteria. Bacterial strains, including the M. abscessus complex, M. avium complex, and other clinically relevant NTM, were cultured and subjected to growth inhibition assays. The results demonstrate significant activity against the most common NTM pathogens from the M. abscessus and M. avium complexes. Variations in activity were observed against other NTM species, with for instance M. ulcerans displaying high susceptibility and M. xenopi and M. simiae resistance to AAPs. Comparative analysis of RNAP β and β′ subunits across mycobacterial species revealed strain-specific polymorphisms, providing insights into differential compound susceptibility. While conservation of target structures was observed, differences in compound activity suggested influences beyond drug–target interactions. This study highlights the potential of AAPs as effective antimycobacterial agents and emphasizes the complex interplay between compound structure, bacterial genetics, and in vitro activity. Full article

Respiratory tract diseases caused by influenza virus and SARS-CoV-2 can represent a serious threat to the health of pregnant women. Immunological remodulation for fetus tolerance and physiological changes in the gestational chamber expose both mother and child to fearful complications and a high risk of hospitalization. Vaccines to protect pregnant women from influenza and COVID-19 are strongly recommended and vaccine co-administration could be advantageous to increase coverage of both vaccines. The attitude to accept both vaccines is affected by several factors: social, cultural, and cognitive-behavioral. In Palermo, Italy, during the 2021–2022 influenza season, a cross-sectional study was conducted to evaluate pregnant women’s intention to adhere to co-administration of influenza and COVID-19 vaccines. The determinants of vaccination attitude were investigated through the administration of a questionnaire and the Health Action Process Approach theory was adopted to explore the cognitive behavioral aspects. Overall, 120 pregnant women were enrolled; mean age 32 years, 98.2% (n = 118) of Italian nationality and 25.2% (n = 30) with obstetric or pathological conditions of pregnancy at risk. Factors significantly associated with the attitude to co-administration of influenza and COVID-19 vaccines among pregnant women were: high level of education (OR = 13.96; p < 0.001), positive outcome expectations (OR = 2.84; p < 0.001), and self-efficacy (OR = 3.1; p < 0.001). Effective strategies to promote the co-administration of the influenza vaccine and the COVID-19 vaccine should be based on the communication of the benefits and positive outcomes of vaccine co-administration and on the adequate information of pregnant women. Full article

The waterfowl industry represents a narrow, yet economically significant, sector within the poultry industry. Although less prominent, the waterfowl sector is nonetheless of equal importance to any other livestock sector in terms of antimicrobial resistance and animal health issues. This study assesses the antimicrobial resistance profile of Pasteurella multocida bacterial strains isolated from clinical cases in Hungary’s duck and goose populations, determining the minimal inhibitory concentration (MIC) of 27 samples collected from 15 different locations. The results indicate that the isolated strains were susceptible to most antibiotics, except for notable resistance to enrofloxacin. These findings support that Pasteurella multocida largely retained its susceptibility. However, the observed resistance to enrofloxacin suggests overuse of fluoroquinolones, which indicates the potential need for stricter regulation of their use in the poultry industry. Full article

Biodiesel stands at the forefront as a replacement for fossil diesel in compression ignition engines, particularly in the transportation sector where diesel engines are the primary movers. However, biodiesel production is hampered by poor heat and mass transfer during the transesterification reaction, leading to long production times and high costs due to inefficient energy utilisation. This study targets heat and mass transfer issues during the production of biodiesel via a synergic approach that combines microwave-assisted heating and microfluidics via a polyethylene terephthalate glycol (PETG) microchannel reactor. The transesterification reaction of palm oil and methanol was investigated using a full factorial design of experiments (DOE) method. Biodiesel yield was quantified via gas chromatographic analysis, and the results were optimised using statistical analysis. Optical analysis of slug quantification within the microchannel revealed that small slugs, smaller than 1 mm, accelerated the transesterification reaction. The composite-optimised experimental results, aimed at minimising energy costs and environmental impacts while maximising fatty acid methyl ester (FAME) yield, indicate a reaction temperature of 50 °C, a catalyst loading of 1.0 wt.%, and a 3:1 methanol to oil molar ratio. Regression analysis revealed that the reaction temperature was statistically insignificant when utilising the PETG microchannel reactor. This key finding positively impacts biodiesel production as it relates to significantly reduced energy intensity, costs, and emissions. Overall, this research work paves a pathway toward an energy-efficient and sub-minute rapid transesterification reaction, highlighting the effectiveness of microwave heat delivery and effects of microfluidics via the PETG microchannel reactor in overcoming heat and mass transfer barriers in biodiesel production. Full article

Neointimal hyperplasia is the main cause of vascular graft failure in the medium term. Vitamin D receptor activation modulates the biology of vascular smooth muscle cells and has been reported to protect from neointimal hyperplasia following endothelial injury. However, the molecular mechanisms are poorly understood. We have now explored the impact of the selective vitamin D receptor activator, paricalcitol, on neointimal hyperplasia, following guidewire-induced endothelial cell injury in rats, and we have assessed the impact of paricalcitol or vehicle on the expression of key cell stress factors. Guidewire-induced endothelial cell injury caused neointimal hyperplasia and luminal stenosis and upregulated the expression of the growth factor growth/differentiation factor-15 (GDF-15), the cytokine receptor CD74, NFκB-inducing kinase (NIK, an upstream regulator of the proinflammatory transcription factor NFκB) and the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Immunohistochemistry confirmed the increased expression of the cellular proteins CD74 and NIK. Paricalcitol (administered in doses of 750 ng/kg of body weight, every other day) had a non-significant impact on neointimal hyperplasia and luminal stenosis. However, it significantly decreased GDF-15, CD74, NIK and MCP-1/CCL2 mRNA expression, which in paricalcitol-injured arteries remained within the levels found in control vehicle sham arteries. In conclusion, paricalcitol had a dramatic effect, suppressing the stress response to guidewire-induced endothelial cell injury, despite a limited impact on neointimal hyperplasia and luminal stenosis. This observation identifies novel molecular targets of paricalcitol in the vascular system, whose differential expression cannot be justified as a consequence of improved tissue injury. Full article

Urban tailwater typically has a low carbon-to-nitrogen ratio and adding external carbon sources can effectively improve the denitrification performance of wastewater. However, it is difficult to determine the dosage of additional carbon sources, leading to insufficient or excessive addition. Therefore, it is necessary to prepare solid slow-release carbon source (SRC) materials to solve the difficulty in determining the dosage of carbon sources. This study selected two SRCs of slow-release carbon source 1 (SRC1) and slow-release carbon source 2 (SRC2), with good slow-release performance after static carbon release and batch experiments. The composition of SRC1 was: hydroxypropyl methylcellulose/disodium fumarate/polyhydroxy alkanoate (HPMC/DF/PHA) at a ratio of 3:2:4, with an Fe₃O₄ mass fraction of 3%. The composition of SRC2 was: HPMC/DF/PHA with a ratio of 1:1:1 and an Fe₃O₄ mass fraction of 3%. The fitted equations of carbon release curves of SRC1 and SRC2 were y = 61.91 + 7190.24e^−0.37t and y = 47.92 + 8770.42e^−0.43t, respectively. The surfaces of SRC1 and SRC2 had a loose and porous morphological structure, which could increase the specific surface area of materials and be more conducive to the adhesion and metabolism of microorganisms. The experimental nitrogen removal by denitrification with SRCs showed that when the initial total nitrogen concentration was 40.00 mg/L, the nitrate nitrogen (NO₃⁻-N) concentrations of the SRC1 and SRC2 groups on the 10th day were 2.57 and 2.66 mg/L, respectively. On the 20th day, the NO₃⁻-N concentrations of the SRC1 and SRC2 groups were 1.67 and 2.16 mg/L, respectively, corresponding to removal efficiencies of 95.83% and 94.60%, respectively. The experimental results indicated that SRCs had a good nitrogen removal effect. Developing these kinds of materials can provide a feasible way to overcome the difficulty in determining the dosage of carbon sources in the process of heterotrophic denitrification. Full article

In this paper, we consider a low-latency Mobile Edge Computing (MEC) network where multiple User Equipment (UE) wirelessly reports to a decision-making edge server. At the same time, the transmissions are operated with Finite Blocklength (FBL) codes to achieve low-latency transmission. We introduce the task of Age upon Decision (AuD) aimed at the timeliness of tasks used for decision-making, which highlights the timeliness of the information at decision-making moments. For the case in which dynamic task generation and random fading channels are considered, we provide a task AuD minimization design by jointly selecting UE and allocating blocklength. In particular, to solve the task AuD minimization problem, we transform the optimization problem to a Markov Decision Process problem and propose an Error Probability-Controlled Action-Masked Proximal Policy Optimization (EMPPO) algorithm. Via simulation, we show that the proposed design achieves a lower AuD than baseline methods across various network conditions, especially in scenarios with significant channel Signal-to-Noise Ratio (SNR) differences and low average SNR, which shows the robustness of EMPPO and its potential for real-time applications. Full article

This research explores Indigenous land-based perspectives on environmental sustainability, centering on the Khasis Indigenous community in Bangladesh. With a critical connection to their land-based cultural heritage and environment, the Khasis community offers a distinctive perspective for examining environmental challenges. Emphasizing the traditional land-based knowledge and practices of the Khasis, as well as their insights on environmental challenges, this study employs a land-based theoretical framework. It sheds light on the adaptive strategies of Khasis Indigenous communities amidst shifting environmental conditions, illustrating how they integrate sustainable practices into daily life by drawing upon Indigenous land-based knowledge and practices to mitigate environmental risks. Additionally, the research scrutinizes the challenges faced by the Khasis in preserving their land-based knowledge, practices, and identity in the face of a global environmental crisis. The findings contribute to broader discussions on Indigenous land-based knowledge and practices and their significance in contemporary climate discourse. By amplifying the voices of the Khasis Indigenous community’s land-based knowledge and practices, this study advocates for the incorporation of Indigenous perspectives into climate policies and interventions. It underscores the necessity for a more inclusive and culturally sensitive approach to environmental sustainability, one that acknowledges and respects the resilience of Indigenous communities like the Khasis in Bangladesh. Full article

Due to limited infrastructure and remote locations, rural areas often need help providing reliable and high-quality network connectivity. We propose an innovative approach that leverages Software-Defined Wide Area Network (SD-WAN) architecture to enhance reliability in such challenging rural scenarios. Our study focuses on cases in which network resources are limited to network solutions such as Long-Term Evolution (LTE) and a Low-Earth-Orbit satellite connection. The SD-WAN implementation compares three tunnel selection algorithms that leverage real-time network performance monitoring: Deterministic, Random, and Deep Q-learning. The results offer valuable insights into the practical implementation of SD-WAN for rural connectivity scenarios, showing its potential to bridge the digital divide in underserved areas. Full article

Household food insecurity (HFI) and poorer prenatal diet quality are both associated with adverse perinatal outcomes. However, research assessing the relationship between HFI and diet quality in pregnancy is limited. A cross-sectional online survey was conducted to examine the relationship between HFI and diet quality among 1540 pregnant women in Australia. Multiple linear regression models were used to examine the associations between HFI severity (marginal, low, and very low food security compared to high food security) and diet quality and variety, adjusting for age, education, equivalised household income, and relationship status. Logistic regression models were used to assess the associations between HFI and the odds of meeting fruit and vegetable recommendations, adjusting for education. Marginal, low, and very low food security were associated with poorer prenatal diet quality (adj β = −1.9, −3.6, and −5.3, respectively; p < 0.05), and very low food security was associated with a lower dietary variety (adj β = −0.5, p < 0.001). An association was also observed between HFI and lower odds of meeting fruit (adjusted odds ratio [AOR]: 0.61, 95% CI: 0.49–0.76, p < 0.001) and vegetable (AOR: 0.40, 95% CI: 0.19–0.84, p = 0.016) recommendations. Future research should seek to understand what policy and service system changes are required to reduce diet-related disparities in pregnancy. Full article

The production of materials with a high affinity for oxidation using the direct metal deposition (DMD) process requires an extended process examination that goes beyond the usual, purely energetic consideration, with the aim of providing sufficient energy to melt the substrate and the powder material supplied. This is because the DMD process does not allow any conclusions to be drawn as to whether it and its respective selected parameters result in an oxidation critical process. To assess this, a superposition of the temperature field with the existing spatial oxygen concentration is required. This work uses this approach to develop an oxidation model that reduces oxidation during the DMD process. In addition to the numerical model, an analytical model is derived, with which the temperature of a material element can be calculated analytically and the resulting boundary oxygen concentration calculated using Fick’s 2nd law. The model also takes into account two-stage oxidation kinetics for Ti alloys. The effect of too high a travel speed (with the same specific energy of the other experiments) is shown visually in the numerical calculation of the temperature field. However, if the process model is taken into account, the components do fulfil the specified requirements. Finally, the effect of oxidation on the microstructure, microhardness, ultimate strength, yield strength and elongation at failure of Ti6Al4V structures produced using DMD is also investigated, and further supports our conclusions regarding the effectiveness of the proposed model. Full article

A theoretical foundation for implementing surface self-cleaning can be provided by analyzing the motion of adhering droplets in airflow. When driving in rainy circumstances, self-cleaning windshield technology can efficiently guarantee driver safety. In this study, the CLSVOF method is employed to simulate a three-dimensional wind tunnel model, enabling an investigation into the dynamics of droplets adhering to a windshield under the influence of airflow. Subsequent analysis mainly focuses on the impacts of wind velocity and droplet size on the motion patterns and morphological characteristics of the droplets. The temporal evolution of the forces acting on the droplets is examined, along with a comparative analysis of the predominant forces driving droplet motion against other forms of resistance. The results demonstrate that the motion patterns of the droplets can be broadly categorized into three phases: accelerated decline, forces equilibrium, and accelerated climb. As wind speed increases, there is a noticeable reduction in the wetting length L_d, while the height of the droplets H and the dominant force influencing their motion shift from gravitational component F_gsinα to wind traction force F_wind. Moreover, an increase in droplet size accentuates the lag in changes to wetting length, droplet height, and the contact angle. Full article

In regions of China experiencing severe cold, the duration of the winter heating season significantly contributes to elevated heating energy consumption in rural dwellings. This study focuses on typical brick-and-concrete rural homes in the Wusu area. Utilizing the Rhino–Grasshopper parametric modeling platform, it aims to minimize heating-related carbon emissions and the overall costs associated with retrofitting. The approach involves improving the insulation properties of the building envelope to reduce energy requirements. Additionally, the study incorporates solar photovoltaic systems atop rural homes, building upon low-carbon, passive, energy-efficient design principles. By examining the influence of various factors on rural housing energy consumption, the research employs the entropy weight method to identify the most effective design solutions. The goal is to explore strategies for the energy-efficient retrofitting of rural dwellings in areas faced with harsh winter conditions, aligning with the objectives and preferences of Applied Sciences. The simulation results reveal the following: (1). In comparison with the baseline scenario, 42.2% of the optimized solutions within the Pareto frontier satisfy the current standards for 75% energy savings in energy-efficient residential design. (2). The lowest recorded thermal consumption index for the buildings can reach 12.427 W/m², at which point the rate of energy savings is elevated to 79.5%. (3). Within the solutions identified by the Pareto frontier, 80% exhibit initial investments that are lower than the cost savings over the lifecycle due to reduced energy consumption ( < 0), demonstrating the economic feasibility of the proposed retrofitting strategies. Full article

The exploration of religious beliefs within the confines of Chinese prisons presents a nuanced inquiry into the intersection of faith, correctional policies, and human rights. This study delves into the underexplored domain of how religious practices and beliefs are navigated within the Chinese penal system. Despite constitutional assurances for religious freedom, practical applications within prison walls reveal a nuanced tapestry of control, accommodation, and, at times, suppression. This paper aims to shed light on these complexities through interviews with prison officers, offering a rare glimpse into the ‘hidden corners’ of religious observance in Chinese prisons. It critically examines the balance between state control, the rehabilitation agenda, and the individual’s right to spiritual belief and practice, proposing a more inclusive approach to fostering religious diversity and freedom within the correctional environment. Full article

Two cohorts of Atlantic bluefin tuna (Thunnus thynnus) larvae were sampled in 2017 and 2018 during the peak of spawning in the Gulf of Mexico (GOM). We examined environmental variables, daily growth, otolith biometry and stable isotopes and found that the GOM18 cohort grew at faster rates, with larger and wider otoliths. Inter and intra-population analyses (deficient vs. optimal growth groups) were carried out for pre- and post-flexion developmental stages to determine maternal and trophodynamic influences on larval growth variability based on larval isotopic signatures, trophic niche sizes and their overlaps. For the pre-flexion stages in both years, the optimal growth groups had significantly lower δ¹⁵N, implying a direct relationship between growth potential and maternal inheritance. Optimal growth groups and stages for both years showed lower C:N ratios, reflecting a greater energy investment in growth. The results of this study illustrate the interannual transgenerational trophic plasticity of a spawning stock and its linkages to growth potential of their offsprings in the GOM. Full article

The administration of mesenchymal stem cells (MSCs) has a positive effect on wound healing; however, the lack of adequate MSC engraftment at the wound site is a major limiting factor in current MSC-based therapies. In this study, a biosheet prepared using in-body tissue architecture (iBTA) was used as a material to address these problems. This study aimed to assess and evaluate whether biosheets containing somatic stem cells would affect the wound healing process in dogs. Biosheets were prepared by subcutaneously embedding molds in beagles. These were then evaluated grossly and histologically, and the mRNA expression of inflammatory cytokines, interleukins, and Nanog was examined in some biosheets. Skin defects were created on the skin of the beagles to which the biosheets were applied. The wound healing processes of the biosheet and control (no biosheet application) groups were compared for 8 weeks. Nanog mRNA was expressed in the biosheets, and SSEA4/CD105 positive cells were observed histologically. Although the wound contraction rates differed significantly in the first week, the biosheet group tended to heal faster than the control group. This study revealed that biosheets containing somatic stem cells may have a positive effect on wound healing. Full article

Designing and installing efficient grounding systems in power distribution networks is considered a complex and crucial task to ensure the reliable operation of power-protective schemes while mitigating hazardous potentials arising from faults, thereby safeguarding both personnel and equipment. This paper aims to offer guidance on designing effective grounding systems in distribution networks by assessing the influence of parameters such as soil structure, fault current magnitude, and fault clearing time. This involves proposing a more precise methodology for calculating hazardous potentials, leveraging software tools like PowerFactory, to accurately determine short-circuit (SC) currents and fault clearing times at specific locations where grounding grids are to be installed. Consequently, Distribution System Operators (DSOs) can design tailored grounding systems that optimize techno-economic considerations without unnecessary over-dimensioning, accounting for the unique characteristics of the Medium-Voltage (MV) Line and soil structure. Full article

The present research work introduces a novel mixture optimization methodology for biodiesel fuels using an Evolutionary Computation method inspired by biological evolution. Specifically, the optimal biodiesel composition is deduced from the application of a nature-inspired adaptive genetic algorithm that first examines percentages of the ingredients in the optimal mixtures. The innovative approach’s effectiveness lies in problem simulation with improvements in the evaluation of the specific function and the way to define and tune the genetic algorithm. Environmental imperatives in the era of climate change currently impose the optimized production of alternative environmentally friendly biofuels to replace fossil fuels. Biodiesel in particular, appears to be more attractive in recent years, as it originates from renewable bio-derived resources. The main ingredients of the specific biofuel mixture investigated in this research are diesel and biodiesel (100% from bioresources). The assessment of the new biodiesel examined was performed using a fitness function that estimated both the density and cost of the fuel. Beyond the evaluation criterion of cost, density also influences the suitability of this biofuel for commercial use and market sale. The outcomes from the modeling process can be beneficial in saving cost and time for new biodiesel production by using this novel decision-making tool in comparison with randomized laboratory experimentations. Full article

The main aim of this article is to derive certain continuity and boundedness properties of the coupled fractional Fourier transform on Schwartz-like spaces. We extend the domain of the coupled fractional Fourier transform to the space of tempered distributions and then study the mapping properties of pseudo-differential operators associated with the coupled fractional Fourier transform on a Schwartz-like space. We conclude the article by applying some of the results to obtain an analytical solution of a generalized heat equation. Full article

The study investigated the impact of nonsteroidal anti-inflammatory drugs (NSAIDs) on burn-induced coagulopathy in severely burned patients. Patients with a greater than 20% TBSA were identified in the TriNetX research network and categorized into receiving or not receiving NSAIDs in the first week after the burn. The statistical significance of the rate of burn-induced coagulopathy, mortality and sepsis in the week following injury was analysed. We observed 837 severely burned patients taking NSAIDS during the week following the burn and 1036 patients without. After matching for age, gender and race, the risk of burn-induced coagulopathy significantly decreased (p < 0.0001) in patients taking NSAIDs (17.7%) compared to those without (32.3%). Patients taking NSAIDs were also less likely to develop sepsis (p < 0.01) and thrombocytopenia (p < 0.001) or die the week following injury (p < 0.0001). In conclusion, the early protective effects of NSAIDs at reducing the risk of coagulopathy as well as sepsis and mortality occur during the acute phase of burns. Full article

The underwater phase (UP) is highly important for overall swimming performance in most swimming events. However, the metabolic effects of the prolonged UP remain unclear. The purpose of this cross-sectional study was to compare the blood lactate response to submaximal front-crawl swimming with short and extended UP. Twelve (four females) junior competitive swimmers (aged 15.4 (1.4) years) undertook 200 m front-crawl swim trials in a 25 m pool at a pre-determined “anaerobic threshold” velocity on two occasions using short (<5 m) and extended (12.5 m) UP after each turn. Pacing and total time were ensured to be identical between the trials. Capillary blood lactate response was measured. Testing for 25 m swim time with <5 m and 12.5 m UP was conducted on a separate occasion. When athletes undertook and extended UP after each propulsion from the wall, their post-exercise blood lactate concentration reached 7.9 (2.1) mmol/L, more than two times higher than the response to trial with short UP (p < 0.001). All-out 25 m swimming with <5 m or 12.5 m UP disclosed no difference in locomotion velocity (p > 0.05). In conclusion, extending UP of submaximal front-crawl swimming close to maximally allowed during the races substantially increases blood lactate accumulation, i.e., increases the reliance on anaerobic metabolism. Therefore, extended UP is most likely counterproductive for the performance in long-distance swimming, at least for the athletes with a FINA score of <800. On the other hand, the extension of UP could be an effective strategy to train ‘lactate tolerance’, lactate shuttling, removal, and recycling. Full article