ExLibris header image
SFX Logo
Title: RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
Source:

Proceedings of the National Academy of Sciences of the United States of America [0027-8424] Picaud, S yr:2013


Collapse list of basic services Basic
Full text
Full text available via PubMed Central
GO
Document delivery
Request document via Library/Bibliothek GO
Users interested in this article also expressed an interest in the following:
1. Chung, C. "Discovery and characterization of small molecule inhibitors of the BET family bromodomains." Journal of medicinal chemistry 54.11 (2011): 3827-3838. Link to Full Text for this item Link to SFX for this item
2. Mirguet, O. "Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains." Journal of medicinal chemistry 56.19 (2013): 7501-7515. Link to Full Text for this item Link to SFX for this item
3. Hay, D. "The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains." MedChemComm 4.1 (2013): 140-144. Link to Full Text for this item Link to SFX for this item
4. Singer, Dinah S. "BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain." Proceedings of the National Academy of Sciences of the United States of America 109.18 (2012): 6927-6932. Link to Full Text for this item Link to SFX for this item
5. Capone, Stefania a. "Electrophilic S-trifluoromethylation of cysteine side chains in α- and β-peptides: isolation of trifluoromethylated Sandostatin (octreotide) derivatives." Helvetica chimica acta 91.11 (2008): 2035-2056. Link to Full Text for this item Link to SFX for this item
6. Gosmini, R. "The Discovery of I-BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor." Journal of medicinal chemistry 57.19 (2014): 4294967295-31. Link to Full Text for this item Link to SFX for this item
7. Weinmann, B. "Bromodomains and Their Pharmacological Inhibitors." ChemMedChem 9.3 (2014): 438-464. Link to Full Text for this item Link to SFX for this item
8. Nicodeme, E. "Naphthyridines as Novel BET Family Bromodomain Inhibitors." ChemMedChem 9.3 (2013): 580-589. Link to Full Text for this item Link to SFX for this item
9. Kwon, Yong-Uk k. "Encoded combinatorial libraries for the construction of cyclic peptoid microarrays." Chemical communications 44 (2008): 5704-5706. Link to Full Text for this item Link to SFX for this item
10. Stanek, K. "Reactivity of a 10-I-3 Hypervalent Iodine Trifluoromethylation Reagent With Phenols." Journal of organic chemistry 73.19 (2008): 7678-7685. Link to Full Text for this item Link to SFX for this item
11. Haynes, S R R. "The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins." Nucleic acids research 20.10 (1992): 2603-2603. Link to Full Text for this item Link to SFX for this item
12. Mai, A. "Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties." Journal of medicinal chemistry 49.23 (2006): 6897-6907. Link to Full Text for this item Link to SFX for this item
13. Chung, Chun-wa W. "The use of biophysical methods increases success in obtaining liganded crystal structures." Acta crystallographica. Section D, Biological crystallography 63.Pt 1 (2006): 62-71. Link to Full Text for this item Link to SFX for this item
14. Goldberg, Aaron D. D. "Epigenetics: A landscape takes shape." Cell 128.4 (2007): 635-638. Link to SFX for this item
15. Borg, S. "Synthesis of 1,2,4-Oxadiazole-, 1,3,4-Oxadiazole-, and 1,2,4-Triazole-Derived Dipeptidomimetics." Journal of organic chemistry 60.10 (1995): 3112-3120. Link to Full Text for this item Link to SFX for this item
16. Hewings, David S. "Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions." Journal of medicinal chemistry 55.22 (2012): 9393-9413. Link to Full Text for this item Link to SFX for this item
17. Mochizuki, K., Nishiyama, A., Jang, M. K., Dey, A., K. "The Bromodomain Protein Brd4 Stimulates G1 Gene Transcription and Promotes Progression to S Phase." The Journal of biological chemistry 283.14 (2008): 9040-9048. Link to Full Text for this item Link to SFX for this item
18. Filippakopoulos, P. "Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening." Journal of medicinal chemistry 56.Copyright (C) 2013 American Chemical Society (ACS). All Rights Reserved. (2013): 8073-8088. Link to Full Text for this item Link to SFX for this item
19. Knapp, S. "A public-private partnership to unlock the untargeted kinome." Nature chemical biology 9.1 (2013): 3-7. Link to SFX for this item
20. Fish, Paul V. "Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit." Journal of medicinal chemistry 55.22 (2012): 9831-9837. Link to Full Text for this item Link to SFX for this item
View More...
View Less...
Select All Clear All

Expand list of advanced services Advanced