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Absolute quantification of high energy phosphate metabolites in normal, hypertrophied and failing human myocardium

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2. Conclusion

For definitive conclusions, larger numbers of patients will have to be studied, but our preliminary results indicate that (1) ATP levels decline in heart failure but not in left ventricular hypertrophy and (2) phosphocreatine/ATP ratios underestimate the true changes in myocardial high-energy phosphate concentrations in chronically injured human myocardium.

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  1. Stefan Neubauer

    Present address: Department of Cardiovascular Medicine, John Radcliffe Hospital, Headley Way, OX3 9DU, Oxford, UK

Authors and Affiliations

  1. Department of Cardiovascular Medicine, Oxford University, Oxford, UK

    Stefan Neubauer, Meinrad Beer, Wilfried Landschütz, Jörn Sandstede, Tobias Seyfarth, Claudia Lipke, Herbert Köstler, Thomas Pabst, Werner Kenn, Martin Meininger, Markus von Kienlin, Michael Horn, Kerstin Harre & Dietbert Hahn

  2. Institut für Röntgendiagnostik, Physikalisches Institut V, Medizinische Klinik, Würzburg University, Würzburg, Germany

    Stefan Neubauer, Meinrad Beer, Wilfried Landschütz, Jörn Sandstede, Tobias Seyfarth, Claudia Lipke, Herbert Köstler, Thomas Pabst, Werner Kenn, Martin Meininger, Markus von Kienlin, Michael Horn, Kerstin Harre & Dietbert Hahn

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  1. Stefan Neubauer
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  2. Meinrad Beer
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Correspondence to Stefan Neubauer.

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Neubauer, S., Beer, M., Landschütz, W. et al. Absolute quantification of high energy phosphate metabolites in normal, hypertrophied and failing human myocardium. MAGMA 11, 73–74 (2000). https://doi.org/10.1007/BF02678501

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  • DOI: https://doi.org/10.1007/BF02678501

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