Skip to main content
SpringerLink
Log in

Standardized MR protocol for the evaluation of MRA sequences and/or contrast agents effects in high-degree arterial stenosis analysis

  • Published:
Magnetic Resonance Materials in Physics, Biology and Medicine Aims and scope Submit manuscript

Abstract

Purpose

To investigate the relative role of high resolution (spatial or temporal) magnetic resonance angiography (MRA) sequence and of contrast agent properties in the evaluation of high-degree arterial stenosis.

Methods

We qualitatively and quantitatively studied both 50 and 95% (300 μm diameter) stenosis of a 6 mm arterial phantom with two contrast agents (CA), Gd-DOTA (r1 =2.9 mM−1 s−1) versus P760 (r1 =25 mM−1 s−1) at several CA concentrations, including arterial peak concentration after injection of either a single or double dose of CA, using either a high temporal (booster) or high spatial (HR) resolution 3D MRA sequences. Experimental data were then compared to theoretical data.

Results

With the 3D HR sequence, both visual and quantitative analysis were significantly better compared to the 3D booster sequence, at each phantom diameter. Quantitative analysis was significantly improved by injection of a double versus a single dose of each CA (Gd-DOTA or P760), primarily in high degree stenosis.

Conclusion

Combined MRA spatial resolution and high CA efficiency are mandatory to correctly evaluate high degree stenosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Maki JH, Chenevert TL. Prince MR. Three-dimensional contrast-enhanced MR angiography. Top Magn Reson Imaging 1996;8(6):322–44.

    Article  PubMed  CAS  Google Scholar 

  2. Prince MR, Narasimham DL. Jacoby VVT, et al. Three-dimensional gadolinium-enhanced MR angiography of thoracic aorta. Am J Radiol. 1996; 166;1387–97.

    CAS  Google Scholar 

  3. Leung DA, Debatin JF, et al. Three-dimensional contrast-enhanced magnetic resonance angiography of thoracic vasculature. Eur Radiol 1997;7:981–9.

    Article  PubMed  CAS  Google Scholar 

  4. Prince MR, Narasimham DL, Stanley JC, et al. Breath-hold gadolinium-enhanced MR Angiography of the abdominal aorta and its major branches. Radiology 1995;197:785–92.

    PubMed  CAS  Google Scholar 

  5. Prince MR, Yucel EK, Kaufman JA, Harrison DC, Geller SC. Dynamic gadolinium-enhanced three-dimensional abdominal MR arteriography. J Magn Reson Imaging 1993;3:877–81.

    Article  PubMed  CAS  Google Scholar 

  6. Nasim A. Thompson MM. Savers RD. et al. Role of magnetic resonance angiography for assessment of abdominal aortic aneurysm before endoluminal repair. Br J Surg 1998;85(5):641–4.

    Article  PubMed  CAS  Google Scholar 

  7. Patel MR, Kuntz KM, Klufas RA, et al. Preoperative assessment of the carotid bifurcation. Can magnetic resonance angiography and duplex ultrasonography replace contrast arteriography. Stroke 1995;26(10):1753–8.

    PubMed  CAS  Google Scholar 

  8. Kim JK, Farb I, Wright GA. Test bolus examination in the carotid artery at dynamic gadolinium-enhanced MR angiography. Radiology 1998;206(l):283–9.

    PubMed  CAS  Google Scholar 

  9. Levy RA, Maki JH. Three-dimensional gadolinium-enhanced MR angiography of the extracranial atherosclerotic carotid arteries: two techniques. Am J NeuroRadiol 1998;4:688–90.

    Google Scholar 

  10. Hany TF, Debatin JF, Leung DA, et al. Evaluation of the aortoiliac and renal arteries: comparison of breath hold, contrast-enhanced, three-dimensional MR angiography with conventional catheter angiography. Radiology 1997;204:357–62.

    PubMed  CAS  Google Scholar 

  11. Bass JC, Prince MR. Londy FJ, Chenevert TL. Effect of gadolinium on phase-contrast MR angiography of the renal arteries. Am J Radiol 1997;1:261–6.

    Google Scholar 

  12. Schoenberg SO, Bock M, Knopp MV, et al. Renal arteries: optimization of three-dimensional gadolinium-enhanced MR angiography with bolus-timing-independent fast multiphase acquisition in a single breath-hold. Radiology 1999;211(3):667–79.

    PubMed  CAS  Google Scholar 

  13. Douek PC, Revel D, Chazel S, Falise B, Villard J, Amiel M. Fast MR angiography of the aortoiliac arteries and arteries of the lower extremity: value of bolus-enhanced, whole-volume substraction technique? Am J Radiol 1995;165:431–7.

    CAS  Google Scholar 

  14. Poon E, Yucel EK, Pagan-Marin H, Kayne H. Iliac artery stenosis measurements: comparison of two-dimensional time-of-flight and three-dimensional dynamic gadolinium-enhanced MR angiography. Am J Radiol 1997;169(4):1139–44.

    CAS  Google Scholar 

  15. Visser K, Hunink M. Peripheral arterial disease: gadolinium-enhanced MR angiography versus color-guided duplex US. A meta-analysis. Radiology 2000;216:67–77.

    PubMed  CAS  Google Scholar 

  16. Lorenz CH., Johansson LOM. Review: contrast-enhanced coronary MRA. J Magn Reson Imaging 1999;10:703–8.

    Article  PubMed  CAS  Google Scholar 

  17. Goldfarb JW, Edelman RR. Coronary arteries: breath hold, gadolinium-enhanced, three-dimensional MR angiography. Radiology 1998;206:830–4.

    PubMed  CAS  Google Scholar 

  18. Marchand B, Douek PC. Benderbous S, Corot C, Canet E. Pilot MR evaluation of pharmacokinetics and relaxivity of specific blood pool agents for MR angiography. Invest Radiol 2000;35(l):41–9.

    Article  PubMed  CAS  Google Scholar 

  19. Corot C, Port M, Raynal I. et al. Physical, chemical, and biological evaluations of P760: a new gadolinium complex characterized by a low rate of interstitial diffusion. J Magn Radiol Imaging 2000;11:182–91.

    Article  CAS  Google Scholar 

  20. Corot C, Violas X. Robert P, Port M. Pharmacokinetics of three gadolinium chelates with different molecular sizes shortly after intravenous injection in rabbits. Relevance to MR angiography. Invest Radiol 2000;35(4):213–8.

    Article  PubMed  CAS  Google Scholar 

  21. Port M. Meyer D, Bonnemain B, et al. P760 and P 775: MRI contrast agents characterized by new pharmacokinetic properties. MAGMA 1999;8:172–6.

    Article  PubMed  CAS  Google Scholar 

  22. Renaudin CD, Barbier B. Roriz R, Revel D., Amiel M. Coronary arteries: new design for three-dimensional arterial phantoms. Radiology 1994;190:579–82.

    PubMed  CAS  Google Scholar 

  23. Gros DR, editor. Animal, Models in Cardiovascular Research. 2nd edition. Dordrecht: Kluwer Academic Publishers; 1994;153:373.

  24. Marchand B, Hernandez-Hoyos M, Orkisz M, Canet E, Douek P. Diagnosis of renal artery stenosis with magnetic resonance angiography and stenosis quantification. J Mal Vasc 2000;25:312–20.

    PubMed  CAS  Google Scholar 

  25. Cremillieux Y, Briguet A, Deguin A. Projection-reconstruction methods: fast imaging sequences and data processing. Magn Reson Med 1994;32:23–32.

    Article  PubMed  CAS  Google Scholar 

  26. Zur Y, Stokar S, Bendel P. An analysis of fast imaging sequences with steady-state transverse magnetization refocusing. Magn Reson Med 1988;6:175–93.

    Article  PubMed  CAS  Google Scholar 

  27. Maki JH, Prince MR, Chenevert TC. Optimizing three-dimensional gadolinium-enhanced magnetic resonance angiography. Original investigation. Invest Radiol 1998;33(9):528–37.

    Article  PubMed  CAS  Google Scholar 

  28. Westcnberg JJM, Wasser MN, van Der Geest RJ, et al. Scan optimization of gadolinium contrast-enhanced three-dimensional MRA of peripheral arteries with multiple bolus injections and in vitro validation of stenosis quantification. Mugn Reson Imaging 1999; 17(1):47–54.

    Article  Google Scholar 

  29. Bourne MW, Margerun L, Hylton N, et al. Evaluation of the effects of intravascular MR contrast media (Gadolinium Dendrimer) on 3D time of flight magnetic resonance angiography of the body. J Magn Reson Imaging 1996;6:305–10.

    Article  Google Scholar 

  30. Loubeyre P, Canet E, Zhao S, Benderbous S, Amiel M, Revel D. Carboxymethyl-dextran-gadolinium-DTPA as a blood pool contrast agent for magnetic resonance angiography. Invest Radiol 1996;31:288–93.

    Article  PubMed  CAS  Google Scholar 

  31. Moseley ME, White DL, Wang JO et al. Vascular mapping using albumin-(Gd-DTPA), an intravascular MR contrast agent, and projection MR imaging. J Comput Assisst Tomogr 1989; 13:215–21.

    Article  CAS  Google Scholar 

  32. Schumann-Giampieri G, Schmitt-Willich H, Frenzel T, et al. In vivo and in vitro -evaluation of Gd-DTPA-polylysine as a macromolecular contrast agent for magnetic resonance imaging. Invest Radiol 1991;26:969–74.

    Article  Google Scholar 

  33. Loubeyre P, Zhao S, Canet E, Abidi H, Benderbouss S, Revel D. Ultrasmall superparamagnetic iron o.xyde particles (AMI 227) as a blood pool contrast agent for MR angiography: experimental study in rabbits. J Magn Radiol Imaging 1997;7:958–62.

    Article  CAS  Google Scholar 

  34. Tanimoto A. Yuasa Y, Hiramatsu K. Enhancement of phase-contrast MR angiography with superparamagnetic iron oxide. J Magn Radiol Imaging 1998;8:446–50.

    Article  CAS  Google Scholar 

  35. Cavagna FM, Maggioni F, Castelli PM, et al. Gadolinium chelates with weak binding to serum proteins. A new class of high-efficiency, general purpose contrast agents for magnetic resonance imaging. Invest Radiol 1997;32:780–96.

    Article  PubMed  CAS  Google Scholar 

  36. Spinazzi A. Lorusso V, Pirovano G, kirchin MA. Safety, tolerance, biodistribution and MR imaging enhancement of the liver with Gd-BOPTA: results of clinical pharmacologic and pilot imaging studies in non-patient and patient volunteers. Acta Radiol 1999;6:282–91.

    Article  CAS  Google Scholar 

  37. Zheng J, Finn P, Carr J, et al. 3D pulmonary perfusion and angiography with a new intravascular contrast agent BR22956/1 in detection of pulmonary flow and perfusion defects. In: Proceedings of the 8th Annual Scientific meeting of the Society of Magnetic Resonance in Medicine. Denvers, Color: Society of Magnetic Resonance in Medicine, 2000:526.

  38. Lauffer RB, Parmelee DJ, Ouellet HS, et al. MS-325:a small-molecule vascular imaging agent for magnetic resonance imaging. Acad Radiol 1996;3:S356–8.

    Article  PubMed  Google Scholar 

  39. Lauffer RB, Parmelee DJ, Dunham SU, et al. MS-325: Albumintargeted contrast agent for MR angiography. Radiology 1998;207:529–38.

    PubMed  CAS  Google Scholar 

  40. Kroft LJ, Doornbos J, van der Geest RJ, Benderbous S, de Roos A. Infarcted myocardium in pigs: MR imaging enhanced with slow-interstitial-diffusion gadolinium compound P 760. Radiology 1999;212(2):467–73.

    PubMed  CAS  Google Scholar 

  41. Dong Q, Hurst DR, Weinmann HJ, Chenevert TL, Londy FJ, Prince MR. Magnetic resonance angiography with Gadomer-17. An animal study original investigation. Invest Radiol 1998;33(9):699–708.

    Article  PubMed  CAS  Google Scholar 

  42. Clarke SE, Weinmann H-J, Dai H, Lucas AR, Rutt BK. Comparison of two blood pool contrast agent for 0.5 T MR angiography: experimental study in rabbits. Radiology 2000;14:787–94.

    Google Scholar 

  43. Rose A. Vision: human and electronic. In: Optical Physics and Engineering. New York: Plenum, 1973.

    Google Scholar 

  44. Watts R, Wang Y, Winchester PA, Khilnani N. Yu L. Rose Model in MRI: noise limitations on spatial resolution and implications for contrast enhanced MR angiography. In: Proceedings of the 19th Annual Scientific meeting of the Society of Magnetic Resonance in Medicine. Denvers, Color: Society of Magnetic Resonance in Medicine, 2000:462.

  45. Boos M. Lentschig M, Scheffler K, Bongartz GM., Steinbrich W. Contrast enhanced magnetic resonance angiography of peripheral vessels. Different contrast agent applications and sequence strategies: a review. Invest Radiol 1998;33:538–46.

    Article  PubMed  CAS  Google Scholar 

  46. Lentschig MG, Reimer P, Rausch-Lentschig UL, Allkemper T, Oelerich M., Laub G. Breath-hold gadolinium-enhanced MR angiography of the major vessels at 1.0 T: dose-response findings and angiographic correlation. Radiology 1998;208:235–357.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire Creatis, UMR 5515. INSA 502, 69621, Vileurbanne, France

    Bruno Marchand, Philippe C. Douek, Jean Pierre Roux, Marcela Hernandez-Hoyos, Maciej Orkisz & Emmanuelle Canet

  2. Department of Radiology, Hôpital de la Croix Rous.se, 103 Grande rue de la Croix Rousse, 69004, Lyon, France

    Bruno Marchand

  3. Department of Radiology, Hôpital Cardiovasculaire Louis Pradel, 28 av Doyen Lepine, 69500, Bron, France

    Philippe C. Douek

  4. Guerbet, Aulnay-sous-Bois, France

    Philippe Robert & Claire Corot

  5. Biostatistiques et Informatique Médicale, 162 av Lacassagne, 69003, Lyon, France

    Patrice Adeleine

  6. Laboratoire de RMN, Université Claude Bernard Lyon 1, 43 Bd du 11 Novembre 1918, 69622, Villeurbanne, France

    Yannick Cremillieux

Authors
  1. Bruno Marchand
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Philippe C. Douek
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Philippe Robert
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Claire Corot
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jean Pierre Roux
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Patrice Adeleine
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Marcela Hernandez-Hoyos
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yannick Cremillieux
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Maciej Orkisz
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Emmanuelle Canet
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bruno Marchand.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Marchand, B., Douek, P.C., Robert, P. et al. Standardized MR protocol for the evaluation of MRA sequences and/or contrast agents effects in high-degree arterial stenosis analysis. MAGMA 14, 259–267 (2002). https://doi.org/10.1007/BF02668220

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02668220

Keywords

Search

Navigation