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Two neuropeptides from synganglia of the hard tick, Ixodes sinensis (Acari: Ixodidae)

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Chinese Science Bulletin

Abstract

Two neuropeptides were isolated from synganglia (central nervous system) of the hard tick, Ixodes sinensis. Their primary sequences were established as Leu-Val-Val-Tyr-Pro-Trp-Thr-Lys and Trp-Glu-Lys-Leu-Gly-Ser-Met-Glu-Thr-Leu. By hot plate bioassay, neuropeptide a displayed strong antinociceptive effect in mice by a dose-dependent behavior, while neuropeptide b had some relaxant effects on the isolated rat strip. These neuropeptides might be involved in down-regulating the host’s defensive reaction.

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Authors and Affiliations

  1. Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China

    Li Jianxu, Yang Hailong, Xu Xueqing & Lai Ren

  2. Graduate School of the Chinese Academy of Sciences, Beijing, 100009, China

    Li Jianxu & Xu Xueqing

  3. Shengyang Orthopaedic Hospital, Shengyang, 110044, China

    Liu Tongguang

  4. College of Biological Sciences, Shenzhen University, Shenzhen, 518060, China

    Liu Zhigang

Authors
  1. Li Jianxu
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  2. Liu Tongguang
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  3. Yang Hailong
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  4. Xu Xueqing
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  5. Liu Zhigang
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  6. Lai Ren
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Correspondence to Lai Ren.

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These authors equally contributed to this work.

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Li, J., Liu, T., Yang, H. et al. Two neuropeptides from synganglia of the hard tick, Ixodes sinensis (Acari: Ixodidae). CHINESE SCI BULL 51, 2743–2747 (2006). https://doi.org/10.1007/s11434-006-2200-3

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  • DOI: https://doi.org/10.1007/s11434-006-2200-3

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