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Hypotensive activity of some dihydroxycoumarins and their congeners

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Summary

Evaluation of the hypotensive activity of dihydroxy coumarins and their congeners reveal that the naturally occurring dimethoxy coumarin Scoparone has maximal activity, more significant than L-α-methyl dopa. Structure activity relationship studies are reported with an attempt to offer a probable mechanism of action.

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Thakur, R.S., Bagadia, S.C. & Sharma, M.L. Hypotensive activity of some dihydroxycoumarins and their congeners. Experientia 34, 158–159 (1978). https://doi.org/10.1007/BF01944649

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