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Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease

Nature Medicine volume 4, pages 428–434 (1998)Cite this article

Abstract

The effects of clinical grade crude preparations of human chorionic gonadotropin (hCG) on Kaposi's sarcoma, HIV, SIV and hematopoiesis were examined in vitro and in vivo. In contrast to previous studies, we report that the antiviral activity of hCG associated factors is not due to the native hCC heterodimer, including its purified subunits or its major degradation product, the β-core. Using gel permeation chromatography of the clinical grade hCC and urine concentrates from pregnant women, we demonstrate that an as yet unidentified hCG associated factor (HAF) with anti-HIV, anti-SIV, anti-KS and pro-hematopoietic activities elutes as two peaks corresponding to 15–30 kDa and 2–4 kDa.

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Authors and Affiliations

  1. Institute of Human Virology, University of Maryland, 725 West Lombard Street, Baltimore, Maryland, 21201-1192, USA

    Yanto Lunardi-Iskandar, Joseph L. Bryant, William A. Blattner, Louis Flamand & Robert C. Gallo

  2. Advanced BioScience Laboratories Inc., 5510 Nicholson Lane, Kensington, Maryland, 20895, USA

    Chia Ling Hung

  3. Presently at Laboratory of Virology, Rheumatology and Immunology Research Center, Pavillen CHUL and Laval University, Quebec, Canada

    Louis Flamand

  4. University of Southern California, School of Medicine, 1441 Eastlake Avenue, Los Angeles, California, 90033, USA

    Parkash Gill

  5. University Libre de Bruxelles, CHU St-Pierre Hospital, Dept. des Maladies Infectious, 322 rue Haute, 1000, Bruxelles, Belgium

    Phillipe Hermans

  6. College of Physicians and Surgeons of Columbia University, 630 W. 168th Street, New York, New York, 10032, USA

    Steven Birken

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  1. Yanto Lunardi-Iskandar
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  2. Joseph L. Bryant
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  3. William A. Blattner
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  4. Chia Ling Hung
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  7. Phillipe Hermans
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  8. Steven Birken
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  9. Robert C. Gallo
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Lunardi-Iskandar, Y., Bryant, J., Blattner, W. et al. Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease. Nat Med 4, 428–434 (1998). https://doi.org/10.1038/nm0498-428

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