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Effects of a single dose of fluoride on calcium metabolism

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Summary

Fluoride 27 mg was given perorally to 14 subjects. It was found that the serum fluoride concentration increased followed by a decrease to normal levels during 24 h. Serum concentrations of calcium and phosphate decreased initially whereas those of serum immunoreactive parathyroid hormone increased. After 24 h the measured quantities were within normal limits. The results are discussed with reference to mineralization of hard tissues and to fluoride treatment of osteoporotic patients.

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Authors and Affiliations

  1. Institute of Dental Pathology and Operative Dentistry, Royal Dental College, Vennelyst Boulevard, DK-8000, Aarhus, Denmark

    M. J. Larsen, F. Melsen, L. Mosekilde & M. S. Christensen

  2. University Institute of Pathology, University of Aarhus, DK-8000, Aarhus, Denmark

    M. J. Larsen, F. Melsen, L. Mosekilde & M. S. Christensen

  3. Medical Department III, Aarhus Amtssygehus, University of Aarhus, DK-8000, Aarhus, Denmark

    M. J. Larsen, F. Melsen, L. Mosekilde & M. S. Christensen

  4. Institute of Pharmacology, University of Aarhus, DK-8000, Aarhus, Denmark

    M. J. Larsen, F. Melsen, L. Mosekilde & M. S. Christensen

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  1. M. J. Larsen
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  2. F. Melsen
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  3. L. Mosekilde
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  4. M. S. Christensen
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Larsen, M.J., Melsen, F., Mosekilde, L. et al. Effects of a single dose of fluoride on calcium metabolism. Calc. Tis Res. 26, 199–202 (1978). https://doi.org/10.1007/BF02013258

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  • DOI: https://doi.org/10.1007/BF02013258

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