Summary
The fine structure of the endothelium lining the femoral and mesenteric veins in the rabbit was examined following the infusion of concentrations of adrenaline varying from 0.5 to 5.0 μg/kg. Control animals were infused with saline.
Vesiculation of the endothelial cells was observed following each infusion of adrenaline, the effect being most marked with the highest dose used. It is suggested that this vesiculation may be associated with the release of antihaemophilic globulin and/or plasminogen activator from the endothelial cells.
Similar content being viewed by others
References
Bloom, A.L., Giddings, J.C., Wilks, C.I.: Factor VIII on the vascular intima. Possible importance in haemostasis and thrombosis. Nature (Lond.) 241, 217–219 (1973)
Cash, J.D., Allan, A.R.: Fibrinolytic response to moderate exercise and intravenous adrenaline in same subjects. Brit. J. Haemat. 13, 276–383 (1967)
Ingram, G.I.C.: Increase in antihaemophilic globulin following infusion of adrenaline. J. Physiol. (Lond.) 156, 217–224 (1961)
Irving, M.H.: The sympatho-adrenal factor in haemorrhagic shock. Ann. roy. Coll. Surg. Engl. 42, 367–386 (1968)
Palade, G.E.: A study of fixation for electron microscopy. J. exp. Med. 95, 285–298 (1952)
Reynolds, E.S.: The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17, 208–213 (1963)
Rhodin, J.A.G.: Ultrastructure of mammalian venous capillaries, venules and small collecting veins. J. Ultrastruct. Res. 25, 452–500 (1968)
Sabatini, D.C., Bensch, K., Barrnett, R.J.: Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. J. Cell Biol. 17, 19–58 (1963)
Todd, A.S.: The histological localisation of plasminogen activator. J. Path. Bact. 78, 281–283 (1959)
Warren, B.A.: Fibrinolytic activity of vascular endothelium. Brit. med. Bull. 20, 213–216 (1964)
Warren, B.A., Khan, S.: The ultrastructure of the lysis of fibrin by endothelium in vitro. Brit. J. exp. Path. 55, 138–148 (1974)
Watson, M.: Staining of tissue sections for electron microscopy with heavy metals. J. biophys. biochem. Cytol. 4, 475–478 (1958)
Weibel, E.R., Palade, G.E.: New cytoplasmic components in arterial endothelia. J. Cell Biol. 23, 101–112 (1964)
Author information
Authors and Affiliations
Additional information
The authors wish to express their gratitude to Mrs. M. Woodford, Miss. G. Moore and Mr. R. Ellis for their skilful technical assistance
Rights and permissions
About this article
Cite this article
Griffiths, N.J., Irving, M.H. & Dixon, J.S. Changes in the fine structure of venous endothelium in the rabbit following adrenaline infusion. Cell Tissue Res. 169, 123–128 (1976). https://doi.org/10.1007/BF00219312
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00219312