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Localization of the human vascular endothelial growth factor gene,VEGF, at Chromosome 6p12

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Abstract

Using overlapping cosmids representing the vascular endothelial growth factor (VEGF) locus, the VEGF gene was mapped by fluorescence in situ hybridization to chromosome 6p12. This localization permits linkage analysis and the identification of gene interaction in the region, as well as alterations of the VEGF structure or expression in cancer cells with chromosome abnormalities.

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Authors and Affiliations

  1. Biological Carcinogenesis and Development Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, 21702, Frederick, MD, USA

    M. -H. Wei

  2. Laboratory of Biology, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA

    N. C. Popescu & D. B. Zimonjic

  3. Laboratory of Immunobiology, National Cancer Institute, National Cancer Institute-Frederick Cancer Research and Development Center, 21702, Frederick, MD, USA

    M. I. Lerman

  4. Surgical Neurology Branch, National Institute for Neurological Disorders and Stroke, National Institutes of health, 20892, Bethesda, MD, USA

    M. J. Merrill

Authors
  1. M. -H. Wei
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  2. N. C. Popescu
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  3. D. B. Zimonjic
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  4. M. I. Lerman
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  5. M. J. Merrill
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Correspondence to M. I. Lerman.

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Wei, M.H., Popescu, N.C., Zimonjic, D.B. et al. Localization of the human vascular endothelial growth factor gene,VEGF, at Chromosome 6p12. Hum Genet 97, 794–797 (1996). https://doi.org/10.1007/BF02346191

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  • DOI: https://doi.org/10.1007/BF02346191

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