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Lymphocyte response in vitro toPlasmodium falciparum merozoite antigens in donors from a holoendemic area

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Abstract

Crude merozoite antigens from Plasmodium falciparum were used to evaluate the profilerative response of peripheral mononuclear cells (PBMCs) from 114 inhabitants of the village of Dielmo (Senegal, West Africa) exposed continuously to malaria transmission. The high or low responses to merozoite antigens obtained in lymphocyte stimulation assays were correlated with the presence or absence of parasites, IFN-γ production and HLA phenotype. The high responders produced high levels of IFN-γ, in contrast to the low responders, most of whom did not secrete IFN-γ (23/27). Among others, the two HLA phenotypes HLA-B51 and HLA-DR1 were significantly associated with a high response (P<0.05).

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Authors and Affiliations

  1. Immunology Unit, Institut Pasteur de Dakar, B.P. 220, Dakar, Sénégal

    Alioune Dieye, Pascal Launois & Jean-Louis Sarthou

  2. Max-Planck-Institut für Biochemie, D-80794, München, Germany

    Hans-G. Heidrich

  3. Service d'Epidémiologie, Institut de Dakar, Dakar, Senegal

    Christophe Rogier

  4. ORSTOM, Dakar, Sénégal

    Jean-Francois Trape

  5. National Institute for Medical Research, Mill Hill, London, UK

    Anthony A. Holder

Authors
  1. Alioune Dieye
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  2. Hans-G. Heidrich
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  3. Christophe Rogier
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  4. Jean-Francois Trape
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  5. Pascal Launois
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  6. Anthony A. Holder
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  7. Jean-Louis Sarthou
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Additional information

This work was supported by a grant from the European Economic Community (contract TS2*CT 90-0312)

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Dieye, A., Heidrich, HG., Rogier, C. et al. Lymphocyte response in vitro toPlasmodium falciparum merozoite antigens in donors from a holoendemic area. Parasitol Res 79, 629–633 (1993). https://doi.org/10.1007/BF00932503

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  • DOI: https://doi.org/10.1007/BF00932503

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